Ryan Zarychanski MD MSc. FRCP(C)

Ryan Zarychanski MD MSc. FRCP(C)
Assistant Professor, University of Manitoba, Sections of Hematology/Medical Oncology and Critical Care
Senior Scientist, Research Institute of Oncology and Hematology, Winnipeg, Manitoba
CancerCare Manitoba ON2051 – 675 McDermot Ave R3E 0V9
Email: [email protected]
Tel: 204.787.1992 Fax: 204.786.0196
CITIZENSHIP:
LANGUAGES:
Canadian
English
CLINICAL EXPERTISE:
Hematology, Critical Care, Epidemiology
CLINICAL RESEARCH
EXPERTISE:
Anticoagulants, evidence-informed transfusion practices in acute
care medicine, massive transfusion,
sepsis, massive transfusion, thrombocytopenia in
critical illness
METHODOLOGIC RESEARCH
EXPERTISE:
Clinical trials, systemic reviews, meta-analysis
EDUCATION
Masters degree
University of Ottawa – Epidemiology and Community Medicine
Ottawa Hospital Research Institute (Ottawa, Canada)
September 2006 – May 2010
Clinician
Investigator
Program (CIP)
Royal College of Physicians and Surgeons of Canada
University of Ottawa (Ottawa, Canada)
September 2006 – September 2008
Critical Care
Fellowship
University of Manitoba,
July 2004-June 2006
Haematology
Fellowship
University of Manitoba/Cancer Care Manitoba
July 2003-June 2005
Internal
University of Manitoba
Medicine Residency July 2000 – June 2003
M.D.
University of Ottawa - Faculty of Medicine
September 1995 - May 2000
B.Sc. Med.
University of Manitoba - Faculty of Medicine
May 1996 - August 1997
B.Sc.
University of Manitoba - Faculty of Science
September 1992 - April 1995
Ryan Zarychanski
PROFESSIONAL COURSES
Academic Health
Sciences Leadership
Program
University of Manitoba and the Winnipeg Regional Health Authority
Centre for Healthcare Innovation, Winnipeg, Canada
October 2013 to March 2014
Acute Critical Events
Simulation (ACES)
Course
Royal College of Physicians & Surgeons of Canada
University of Calgary, Calgary, Alberta
July 2005
CERTIFICATIONS
FRCPC
Fellow of the Royal College of Physicians and Surgeons of Canada
Internal Medicine, Haematology, Critical Care, & Clinical Investigator Programme
USMLE
MCC
Completed all three parts of the United States Medical Licensing Exam
Medical Council of Canada. Granted December, 2001
ROYAL COLLEGE OF PHYSICIANS AND SURGEONS OF CANADA SPECIALTY CERTIFICATES
Clinician Investigator Programme – September 2008
Critical Care – September 2006
Haematology - September 2005
Internal Medicine – June 2004
PROFESSIONAL AFFILIATIONS
Canadian Critical Care Trials Group – Member
Society of Critical Care Medicine – Member
Canadian Intensive Care Foundation – Member
American Society of Hematology – Member
International Society of Thrombosis and Haemostasis – Member
The Society for Clinical Trials – Member
Canadian Society of Clinical Investigation – Member
Royal College of Physicians and Surgeons of Canada – Fellow
College of Physicians and Surgeons of Manitoba – Member in good standing
Ryan Zarychanski
CURRENT POSITIONS HELD
2013 – PRESENT
Senior Scientist
Research Institute of Oncology and Hematology, CancerCare Manitoba.
University of Manitoba, Winnipeg, Manitoba, Canada
2011 - PRESENT
Director, Knowledge Synthesis Unit
Centre for Health Care Innovation
Winnipeg, Manitoba, Canada
2011 - PRESENT
Medical Director, Therapeutic Apheresis Program
Winnipeg Regional Health Authority
Winnipeg, Manitoba, Canada
2009 - PRESENT
Assistant Professor
Department of Internal Medicine,
Sections of Hematology/Medical Oncology and Critical Care
Department of Epidemiology and Community Health Sciences
University of Manitoba, Winnipeg, Manitoba, Canada
2009 - PRESENT
Hematologist and Clinician Scientist
CancerCare Manitoba, Department of Haematology and Medical Oncology
Winnipeg, Manitoba, Canada
PREVIOUS POSITIONS
2006-2008
Clinical Research Fellow
University of Ottawa, and the Ottawa Hospital Research Institute
Clinical Epidemiology Programme
Supervisors: Paul Hébert, Dean Fergusson and Deborah Cook
Ottawa, Ontario, Canada
2004-2006
2003-2005
2000-2003
Clinical Fellow – Critical Care Medicine. University of Manitoba
Clinical Fellow – Haematology. University of Manitoba
Medical Resident – Internal Medicine. University of Manitoba
Winnipeg, Manitoba. Canada
Ryan Zarychanski
PEER REVIEW
GRANT REVIEW
Canadian Institutes of Health Research
 Randomized Controlled Trials (RCT) Committee (2011, 2012, 2014,
2015)
 College of Reviewers (2014 – present)
Canadian Critical Care Trials Group
 Internal Grant and Manuscript review (2010-present)
MANUSCRIPT
REVIEW
New England Journal of Medicine/NEJM (2015)
The Lancet (2013-Present)
Cochrane Library (2013-Present)
Intensive Care Medicine (2013-Present)
Cancer Epidemiology (2012-Present)
BMC Pulmonary Medicine (2012-Present)
Annals of Internal Medicine (2011-Present)
British Medical Journal (2010-Present)
Canadian Medical Association Journal (2009-Present)
Critical Care Medicine (2009-Present)
International Journal of Infectious Disease (2009-Present)
CONFERENCE
ABSTRACTS
American Society of Hematology, 2009
American Society of Hematology, 2010
 Abstract review coordinator, Antithrombotic agents
BSC. MED
ABSTRACTS
University of Manitoba, 2011, 2012
Ryan Zarychanski
SUPERVISION AND MENTORSHIP
RESIDENTS, FELLOWS, AND POSTDOCTORAL TRAINEES
Murdoch Leeies
Emergency Medicine,
Resident
University of Manitoba
(Winnipeg, Canada)
Chantalle Menard
Internal Medicine,
Resident
University of Manitoba
(Winnipeg, Canada)
Post-intubation hypotension
with ketamine and etomidate in
acute traumatic brain injury
patients who require ventilation
2014 - present
Timing of thrombocytopenia in
patients with septic shock
(retrospective cohort study)
2014 – present
Primary Supervisor
Brett Houston
Internal Medicine,
Resident
University of Toronto
(Toronto, Canada)
Jennifer Yamamoto
Internal Medicine,
Resident
University of Manitoba
(Winnipeg, Canada)
HALO (unfractionated heparin
to improve outcomes in septic
shock) translational analysis
2014 – present
Primary Co-Supervisor with Alison
Fox-Robichaud
Preoperative therapeutic
apheresis for severe medically
refractory amiodarone-induced
thyrotoxicosis: a case report
2013
Primary Supervisor
Manuscript PUBLISHED
(Journal of Clinical Apheresis)
Second Prize – CancerCare
Research Day, 2013
Meghan Azad,
Post Doctoral Fellow
University of Alberta
(Edmonton, Alberta)
Probiotic Supplementation
During Pregnancy or Infancy for
the Prevention of Wheeze and
Asthma: A Systematic Review
and Meta-Analysis
Nucleated red blood cells as an
independent predictor of ICU
mortality and ICU recidivism
2013-2014
Primary Supervisor
Manuscript PUBLISHED
(British Journal of Medicine)
Owen Mooney
Critical Care Fellow
University of Manitoba
(Winnipeg, Canada)
Dr. Emily Rimmer
Hematology Fellow
University of Manitoba
(Winnipeg, Canada)
Dr. Bryce Makar
Successful management of a
patient with hemophila A
requiring coronary artery bypass
grafting (case report)
2012-2013
Primary Supervisor
Manuscript under preparation
First Prize – Internal Medicine
Resident Research Day
Clinical outcomes associated
2010-2012
with activated protein C: A
Primary Supervisor
retrospective propensity matched Abstract accepted to SCCM
study
Manuscript PUBLISHED
(Critical Care Medicine)
Massive Transfusion research
2009-2012
Ryan Zarychanski
Emergency Medicine
Resident,
University of Manitoba
(Winnipeg, Canada)
Dr. James Paul
Oncology Fellow
University of Manitoba
(Winnipeg, Canada)
Dr. Mawash Saeed
Internal Medicine
Resident
University of Manitoba
(Winnipeg, Canada)
Dr. Angela Desautels
Internal Medicine
Resident
University of Manitoba
(Winnipeg, Canada)
Dr. Kanwal Kumar,
Cardiac Surgery Resident
University of Manitoba
(Winnipeg, Canada)
Program. (Retrospective cohort
study)
Primary Supervisor
Abstract accepted to SCCM
1st Manuscript under preparation
Second Prize – CancerCare
Research Day, 2011
Second Prize – CancerCare
Research Day, 2012
Adverse Events Associated With 2010-2011
Bone Marrow Biopsy In a
Primary Supervisor
Resident Training Program
First Prize – Internal Medicine
Resident Research Day
Classical Hodgkin’s lymphoma
2010-2011
presenting with autoimmune
Primary Supervisor
dysregulation and systemic
Manuscript PUBLISHED
inflammation (case report)
American Journal of Hematology
Acute promyelocytic leukemia
(APL) in the absence of
peripheral blood abnormalities
(case report)
2011
Primary Supervisor
Abstract/Poster presented at
Resident Research Day, 2011
The Impact of Twenty-Four
Hour In-House Intensivists on a
Dedicated Cardiac Surgery
Intensive Care Unit
2008-2009
Co-supervisor
Manuscript PUBLISHED
(Ann Thorac Surg)
Ryan Zarychanski
GRADUATE – (MSC & PHD) TRAINEES
Murdoch Leeies
Intravenous Immunoglobulin
(MSc. Candidate)
(IVIG) in Septic Shock
Critical Care, Resident
University of Manitoba
(Winnipeg, Canada)
Emily Rimmer MD
Incidence, severity and risk for
(MSc. Candidate)
bleeding in critically ill patients
University of Manitoba
receiving anticoagulation
(Winnipeg, Manitoba)
Christine Fedorow MD
Efficacy and safety of fibrinogen
(MSc. Candidate)
concentrates in cardiac surgery
University of Manitoba
(Winnipeg, Manitoba)
Project (non thesis) supervision to Graduate Students
Daryl Hurrie
Efficacy of iron replacement
(PhD Candidate)
therapy on fatigue and work
University of Manitoba
capacity in non-anemic adults
(Winnipeg, Manitoba)
with iron depletion: a systematic
review of randomized controlled
trials
Jessica Dennis,
Ph.D Candidate
University of Toronto
(Toronto, Canada)
Jessica Dennis,
Masters Student
University of Ottawa
(Ottawa, Canada)
The impact of Provincial helmet
legislation on the rate of bicycle
related head injuries among
children and adults
The Effects of Provincial
Bicycle Helmet Legislation on
Helmet Use and Recreational
Bicycle Ridership in Canada.
2015 - present
2011-Present
Primary Supervisor
2012-2013
Primary Supervisor for this thesis
Thesis withdrawn
2013-2014
Primary Supervisor for this project
Manuscript – Under Review
(CMAJ)
First Prize – Health Leisure and
Human Performance Research Day,
2014
2011-2013
Primary Supervisor for this project
Manuscript – PUBLISHED
(British Medical Journal)
2008- 2010
Primary Supervisor for this project
Manuscript PUBLISHED
(Injury Prevention)
Ryan Zarychanski
BSC. (MED) SUPERVISION
Brett Houston
Medical Student,
University if Manitoba
(Winnipeg, Canada)
Phenotypic and genotypic
evaluation of a Manitoba
kindred with haemolytic
anaemia associated with
decreased osmotic fragility.
Mutations in the
mechanotransduction protein
PIEZO1 are associated with
hereditary xerocytosis
2010-2012
Role: Primary Supervisor
Manuscript PUBLISHED
(Red Cells Molecules and Diseases)
Manuscript PUBLISHED
(Blood)
 Operating grant from the
Manitoba Medical Services
Foundation ($20,000)
 Travel award to American
Society of Hematology (ASH),
2010 ($500)
 ASH Trainee Award ($5000)
 ASH abstracts, 2010 and 2011
 Manuscript accepted for
publication
 First Prize – CancerCare
Research Day, 2011
 Best Clinical BSc. (Med) project
– University of Manitoba
 Best Dissertation with the Most
Significant Merit (BSc. (Med) –
University of Manitoba)
 Travel award to the National
Student Research Forum
(Galveston, TX) 2012
 First Prize – CancerCare
Research Day, 2012
 Second Prize – U.S. National
Student Research Forum
 Winner – Oral Presentation –
Canadian national Medical
Student Research Symposium
Ryan Zarychanski
MEDICAL STUDENT SUPERVISION
Patrick Boreskie
(Med III)
University of Manitoba
(Winnipeg, Canada)
Jessica Cudmore
(Med IV)
University of Manitoba
(Winnipeg, Canada)
Management of massive
transfusion in Cardiac Surgery
2014
Manuscript under preparation
Methotrexate toxicity in a
patient with ulcerative colitis
2010-2011
Primary Supervisor
Allison Stasiuk
(Med II) / Pharmacist
University of Manitoba
(Winnipeg, Manitoba)
Sedation and analgesia usage in
severe H1N1 (2009) infection
Manuscript PUBLISHED
Canadian Family Physician
2009-2010
Primary Supervisor
Manuscript PUBLISHED
Annals of Pharmacotherapy
UNDERGRADUATE STUDENT SUPERVISION
Heather Wittick
(Bachelors of Science)
University of Winnipeg
(Winnipeg, Canada)
Regulators of iron overload in
patients with hereditary
xerocytosis
2012-2013
Primary Supervisor
Abstract accepted to American
Society of Hematology (ASH), 2013
Ryan Zarychanski
FUNDING: AWARDED
July 2015
CanVECTOR (Canadian Venous Thromboembolism Clinical Trials and
Outcomes Research) Network
Principal Investigators: Marc Rodger & Susan Kahn
Co Applicants: Afilalo M; Anderson D; Bates S; Blostein M; Carrier M;
Castellucci L; Chagnon I; Chitsike R; Conway E; Crowther M; de Wit K;
Demers C; Dolan S; Douketis J; Duffett L; Emed J; Fergusson D; Gandara E;
Geerts W; Ginsberg J; Gonsalves C; Grad R; Gross P; Guindon G; Haynes R;
Hirsch A; Iorio A; Kassis J; Kearon C; Kovacs MJ; Lang ES; Lazo-Langner
A; Le Gal G; Lee AY; Levinson AJ; Levy AR; Liaw PC; Lim W; Linkins L;
Louzada MD; McLeod AG; Moodley U; Pai M; Pluye P; Ramsay TO; Ray
JG; Roussin A; Routhier N; Schulman S; Selby R; Shivakumar SP; Siegal
DM; Smith RE; Solymoss S; Tagalakis V; Takach Lapner S; Thavorn K;
Weitz JI; Wells PS; Wu CM; Zarychanski R
Funding: Canadian Institute of Health Research (CIHR), Community
Development Program Grants
Funds Awarded: $1,500,000
Years: 5
July 2015
Tranexamic Acid during Cystectomy Trial (TACT)
Principal Investigators: Rodney H. Breau, Ilias Cagiannos, Franco Momoli.
Co Applicants: Bryson G, Cameron C, Fergusson DA, Fradet V, Kanji S,
Knoll G, Morash C, Morash C, Turgeon A, Zarychanski R.
Funding: Canadian Institute of Health Research (CIHR)
Funds Awarded: $394,050
Years: 3
March 2014
Transfusion of Plasma Prior to Invasive Procedures Pilot Trial
Principal Investigators: Dr. Alan Tinmouth and Dean Fergusson
Co Applicants: Zarychanski R, Chasse M, Laroche V, McIntyre L, Turgeon
AF
Funding: Canadian Institute of Health Research (CIHR)
Funds Awarded: $317,274
Years: 2.5
June 2014
Bleeding, transfusion, and the use of anticoagulants in patients with
critical illness: Generating evidence to inform practice change and
improve clinical outcomes
Principal Investigator: Dr. Ryan Zarychanski
Funding: Canadian Institute of Health Research (CIHR) New Investigator
Award
Funds Awarded: $300,000 (SALARY AWARD)
Years: 5
Ryan Zarychanski
March 2014
Defining the burden and managing the effects of psychiatric comorbidity
in chronic immunoinflammatory disease
Principal Applicant: Dr. Ruth Ann Marrie
Co Applicants: Bernstein CN, Bolton J, Graff L, Walker J, Sareen J,
Zarychanski R, Katz A, Blanchard J, Frisk J, Berrigan L, Patten S, Ghaffar,
Lix L, Hitchon C
Funding: Canadian Institutes of Health Research (CIHR)
Funds Awarded: $2,500,000
Years: 5
February 2014
The George and Fay Yee Centre for Healthcare Innovation
Program: Support for People and Patient-Oriented Research and Trials
(SUPPORT) Units
Principal Applicant: Dr. Terry Klassen
Co Applicants: Wittmeier K, Zarychanski R, Bohm E, Krupka F, Lix L,
Abou-setta AM, Mamoud S, Jiang D, Hinrichsen A
Collaborators: Martens P, Moses S, Woodgate R, Dean H, Van de Mosselaer
G, Anderson-De Coteau M, Weise C, Vielfaure-Mackenzie M, Barnard D
Funds Awarded: $29,682,742
Funding partners:
Canadian Institutes of Health Research (CIHR) $11,232,049
Manitoba Health $5,000,000
The Winnipeg Regional Health Authority (WRHA) $16,884,582
University of Manitoba $7,798,160
Years: 5
November 2013
Effect of unfractionated heparin on cell free DNA and fibrinolysis in
Septic Shock – HALO translational analysis
Principal Applicant: Dr. Ryan Zarychanski
Funding: Bayer
Funds Awarded: $50,000
Years: 1
June 2013
Mechanisms of inflammation and thrombosis in septic shock: Heparin
anticoagulation to improve outcomes in septic shock: - Translational
Analyses
Principal Applicant: Dr. Ryan Zarychanski
Co Applicants: Liaw P, Banerji V, Fox-Robichaud A
Funding: CancerCare Manitoba Foundation
Funds Awarded: $58,000
Years: 2
March 2012
Heparin anticoagulation to improve outcomes in septic shock: The HALO
Pilot
Principal Investigators: Dr. Ryan Zarychanski and Dean Fergusson
Ryan Zarychanski
Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hebert
PC, Houston DS, Kanji S, Kumar A, Liaw P, Marshall J, McIntyre L, Ramsay
T, Tinmouth A, Turgeon AF
Funding: Canadian Institute of Health Research (CIHR)
Funds Awarded: $288,152
Years: 2
March 2012
Early determination of long-term prognosis in critically ill patients with
severe traumatic brain injury (TBI-Prognosis multi-centre prospective
study)
Principal Investigator: Alexis F Turgeon
Co Applicants: Bagshaw S, Bernard F, Burns K, Fergusson D, Green R,
Griesdale D, Kutsogiannis J, Lamontagne F, Lauzier F, Martin C, McIntyre L,
Meade M, Moore L, Moulin V, Pagliarello G, Reynolds S, Rigamonti A,
Savard M, Scales D, Zarychanski R, Zygun D.
Funding: Canadian Institute of Health Research (CIHR)
Funds Awarded: $1,141,067
Years: 3
March 2012
Tranexamic Acid in Cystectomy Trial (TACT) pilot study
Principal Investigators: Rodney H. Breau, Ilias Cagiannos, Franco Momoli.
Co Applicants: Bryson G, Kanji S, Morash C, Turgeon A, Zarychanski R.
Funding: Canadian Institute of Health Research (CIHR)
Funds Awarded: $244,275
Years: 1
March 2011
Heparin anticoagulation to reduce death in septic shock: HADES Pilot
Principal Investigators: Ryan Zarychanski and Dean Fergusson
Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hebert
PC, Houston DS, Kanji S, Kumar A, Marshall J, McIntyre L, Ramsay T,
Tinmouth A, Turgeon AF
Collaborators: Liaw P
Funding: Canadian Institute of Health Research (CIHR)
Funds Awarded: $100,000
Years: 2 years
March 2011
Heparin anticoagulation to reduce death in septic shock: HADES Pilot
Principal Investigators: Ryan Zarychanski and Dean Fergusson
Co Applicants: Bernstein CN, Carrier M, Cook DJ, Fox-Robichaud A, Hebert
PC, Houston DS, Kanji S, Kumar A, Marshall J, McIntyre L, Ramsay T,
Tinmouth A, Turgeon AF
Collaborators: Liaw P
Funding: Manitoba Health Research Council (MHRC)
Funds Awarded: $100,000
Years: 2 years
June 2011
Screening for occult malignancy in patients with unprovoked venous
Ryan Zarychanski
thromboembolism: a randomized controlled trial using a comprehensive
computed tomography of the abdomen/pelvis (SOME trial)
Principal Investigator: Marc Carrier
Co-Applicants: Zarychanski R, Coyle D, Ramsay T, Tao H, Lazo-Langner A,
Rogder M, Wells P, Le Gal G, Taglakis V,
Funding: Heart and Stroke Foundation of Canada
Funds Awarded: $202,590
Years: 3 years
December 2010
Phenotypic and genotypic evaluation of a family cohort with haemolytic
anaemia
Principal Investigator: Ryan Zarychanski
Co-Applicants: Houston BL, Houston DS, Israels S
Funding: Manitoba Medical Services Foundation
Funds Awarded: $20,000
Years: 1 year
July 2010
CIHR Randomized Controlled Trials: Mentoring Award
Principal Investigator: Ryan Zarychanski
Mentor: Fergusson DA
Co-mentors: Bernstein CN, Houston DS, Cook DJ
Funding: Canadian Institute of Health Research (CIHR)
Funds awarded: $160,000 (SALARY AWARD)
Years: 2 years
July 2010
Weaning and Variability Evaluation (WAVE)
Principal Investigator: Andrew Seely
Co-Applicants: Zarychanski R, Fergusson DA, Ferguson N, Lellouche F
Marshal J, Maziak DE, McIntyre LA, Ramsay TO, Rubenfeld G, Scales DC
Funding: Canadian Institutes of Health Research (CIHR), Operating Grant
Funds awarded: $544,134
Years: 3 years
July 2010
Epidemiology of Thromboembolism in Critical Care (EPITEC)
Principal Investigator: Deborah J Cook
Co-Applicants: Zarychanski R, Crowther M, Fowler R, Jacka M, Meade M,
Turgeon A, Devereaux P, Hall R, Lauzier F, Mehta S, Dodek P, Herridge M,
Marshall J, Muscedere J
Funding: Canadian Institutes of Health Research (CIHR), Operating Grant
Funds Awarded: $63,899
Duration: 1 year
September 2009
Plasma Utilization in Cardiac Surgery (PUCS): A Multicentre
Observational Study
Principal Investigator: Dr. Alan Tinmouth
Co-Applicants: Zarychanski R, Fergusson DA, Hebert P, Fraser R
Shehata N, Webert K
Ryan Zarychanski
Funding: Canadian Institutes of Health Research, Operating Grant
Funds awarded: $206,885
Duration: 1 year
January 2009
Research Support / New Faculty Start up Funding
Funding Source: CancerCare Manitoba
Principal Investigator: Ryan Zarychanski
Funding awarded: $225,000
Duration: 3 years
July 2006
Canadian Blood Services Research Fellowship
Principal Investigator: Ryan Zarychanski
Funding Source: Canadian Blood Services
Funding Awarded: $142,000 (SALARY AWARD)
Duration: 2 years
Ryan Zarychanski
PUBLICATIONS
**ALL CAPS denotes research supervisor to trainees
Accepted or in Press
HOUSTON BL, Govia R, Abou-Setta AM, Reid GJ, Hadfield M, Menard C, Noyd J, Main S,
Zarychanski R (senior author/supervisor). Severe Rh alloimmunization and hemolytic disease of the
fetus managed with plasmapheresis, intravenous immunoglobulin and intrauterine transfusion: a case
report. Transfusion and Apheresis Science. 2015
MENARD CM, Zawadski D, Singal RK, Rimmer E, Houston DS, Zarychanski R (senior
author/supervisor). Coronary artery bypass surgery in a patient with Haemophilia A: A case report.
Haemophilia. 2015
Published
68. Carrier M, Lazo-Langner A, Shivakumar S, Tagalakis V, Zarychanski R, Solymoss S, Routhier
N, Douketis J, Danovitch K, Lee AY, Le Gal G, Wells PS, Corsi D, Ramsay T, Coyle D, Chagnon I,
Kassam Z, Tao H and Rodger MA for the SOME Investigators. Screening for occult cancer in
unprovoked venous thromboembolism. New England Journal of Medicine/NEJM. 2015 Jun 22.
[Epub ahead of print] PMID:26095467
67. Zarychanski R, Kumar A. What is the best heparin to treat sepsis with? [Author Reply to: The
efficacy and safety of heparin in patients with sepsis: A systematic review and meta-analysis.
Critical Care Medicine. 2015 June;43(6):e213. PMID:25978177
66. Fowler RA, Abdelmalik P, Wood G, Foster D, Gibney N, Bandrauk N, Turgeon, AF,
Lamontagne F, Kumar A, Zarychanski R, Green R, Bagshaw S, Stelfox HT, Foster R, Dodek, P,
Shaw SM, Granton, J, Lawless B, Hill A, Rose L, Adhikari NK, Scales DC, Cook DJ, Marshall JC,
Martin C, Jouvet P, on behalf of the Canadian ICU Capacity Group and the Canadian Critical Care
Trials Group. Critical Care capacity in Canada: results of a national cross-sectional survey. Critical
Care. 2015 Apr 1;19(1):133. PMID:25888116
65. Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, Clayton L, McIntyre
L, Callum J, Turgeon AF, Blajchman MA, Walsh TS, Stanworth SJ, Campbell H, Capellier G,
Tiberghien P, Bardiaux L, van de Watering L, van der Meer NJ, Sabri E, Vo D; ABLE Investigators;
Canadian Critical Care Trials Group. Age of blood in critically ill adults. New England Journal of
Medicine/NEJM. 2015 Apr 9;372(15):1410-8. PMID:25853745
64. RIMMER E, Houston BL, Cook DJ, Turgeon AF, Kumar A, Friesen C, Houston DS, Abou-Setta
AM, Zarychanski R (senior author/supervisor). The efficacy and safety of plasmapheresis in sepsis
and septic shock: A systematic review and meta-analysis. Critical Care. 2014, 18:699
DOI: 10.1186/s13054-014-0699-2 [Epub ahead of print] PMID:25527094
Ryan Zarychanski
63. Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E,
Houston BL, McIntyre L, Fox-Robichaud AE, Hébert P, Cook DJ, Fergusson DA. The efficacy and
safety of heparin in patients with sepsis: A systematic review and meta-analysis. Critical Care
Medicine. 2015 Mar;43(3):511-8. PMID:25493972
62. Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L,
Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ,
Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O,
Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; for the PROphylaxis for ThromboEmbolism in
Critical Care Trial Investigators, the Canadian Critical Care Trials Group, and the Australian and
New Zealand Intensive Care Society Clinical Trials Group. Failure of Anticoagulant
Thromboprophylaxis: Risk Factors in Medical-Surgical Critically Ill Patients. Critical Care
Medicine. 2015;43:401-10. PMID:25474533
61. Gershengom HB, Wunsch H, Scales DC, Zarychanski R, Rubenfeld G, Garland A. Relationship
between Arterial Catheter Use and Hospital Mortality in Intensive Care Units. JAMA Internal
Medicine. 2014;174(11):1746-54. PMID: 25201069
60. Manyanga T, Froese M, Zarychanski R, Abou-Setta AM, Friesen C, Tennenhouse M, Shay BL.
Pain management with acupuncture in osteoarthritis: A systematic review and meta-analysis. BMC
Complement Altern Med. 2014 Aug 23;14(1):312. [Epub ahead of print] PMID: 25151529
59. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, Zarychanski R, Lacroix J, Fergusson
DA, Desjardins P, Turgeon AF. Red blood cell transfusion in patients with traumatic brain injury: a
systematic review protocol. Systematic Reviews. 2014;3(1):66. doi: 10.1186/2046-4053-3-66
PMID: 24943006
58. Enns JE, Yeganeh A, Zarychansk R, Abou-Setta AM, Friesen C, Zahradka R, Taylor CG. The
impact of Omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular
events and complications in peripheral arterial disease: A systematic review and meta-analysis.
BMC Cardiovascular Disorders. 2014 May 31;14:70. doi: 10.1186/1471-2261-14-70
PMID: 24885361
57. Kumar K, Singal R, Manji RA, Zarychanski R, Bell DD, Freed DH, Arora RC on behalf of the
Cardiovascular Health Research in Manitoba Investigator Group. The benefits of 24/7 in-house
intensivist coverage for prolonged-stay cardiac surgery patients. Journal of Thoracic and
Cardiovascular Surgery. 2014;148(1):290-297 PMID: 24703332
56. CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). Methotrexate and
trimethoprim-sulfamethoxazole: Toxicity from this combination continues to occur. Canadian
Family Physician. 2014:60(1):53-6. PMID: 24452563
55. AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, AbouSetta AM, Zarychanski R (senior author/supervisor). Probiotic Supplementation During Pregnancy or
Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. British
Medical Journal/BMJ. 2013;347:f6471. PMID: 24304677
Ryan Zarychanski
54. YAMAMOTO J, Dostmohamed H, Schacter I, Ariano RE, Lewis B, Knoll C, Katz P,
Zarychanski R. (senior author/supervisor). Preoperative therapeutic apheresis for severe medically
refractory amiodarone-induced thyrotoxicosis: A case report. Journal of Clinical Apheresis.
2014;29(3):168-70. PMID: 24265247
53. Zarychanski R, Dennis J, Singh H. Challenges of population-based colorectal cancer screening
and the importance of time-trend analysis when evaluating system change. Cancer Epidemiology.
2013;37:957-958 [Editorial]. PMID: 24210585
52. Bagshaw SM1, Sood MM, Long J, Fowler RA, Adhikari NK; Canadian Critical Care Trials
Group H1N1 Collaborative. Acute kidney injury among critically ill patients with pandemic H1N1
influenza A in Canada: cohort study. BMC Nephrol. 2013 Jun 13;14:123. doi: 10.1186/1471-236914-123. PMID: 23763900
51. Goldenberg BA, Graff LA, Clara I, Zarychanski R, Walker JR, Carr R, Rogala L, Miller N,
Bernstein CN. Is iron deficiency in the absence of anemia associated with fatigue in inflammatory
bowel disease? American Journal of Gastroenterology. 2013;108:1392-1397. PMID: 24005345
50. Hallet J, Lauzier F, Mailloux O, Trottier V, Archambault P, Zarychanski R, Turgeon AF. The
use of higher Platelet:RBC transfusion ratio in the acute phase of trauma resuscitation: a systematic
review. Critical Care Medicine. 2013;41(12):2800-11. PMID: 23982024
49. Lauzier F, Arnold DM, Rabbat C, Heels – Ansdell D, Zarychanski R, Dodek P, Ashley BJ,
Albert M, Khwaja K, Ostermann M, Skrobik Y, Fowler R, McIntyre L, Nates JL, Karachi T, Lopes
RD, Zytaruk N, Finfer S, Crowther M, Cook D - For the PROTECT Investigators, the Canadian
Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical
Trials Group. Risk factors and impact of major bleeding in critically ill patients receiving heparin
thromboprophylaxis. Intensive Care Medicine. 2013;39:2135-2143. PMID: 23942857
48. Williamson DR, Albert M, Heels-Ansdell D, Arnold DM, Lauzier F, Zarychanski R, Crowther
M, Warkentin TE, Dodek P, Cade J, Lesur O, Lim W, Fowler R, Lamontagne F, Langevin S, Freitag
A, Muscedere J, Friedrich JO, Geerts W, Burry L, Alhashemi J, Cook DJ. Thrombocytopenia in
critically ill patients receiving thromboprophylaxis: frequency, risk factors and outcomes. Chest.
2013;144(4):1207-15. PMID: 23788287
47. RIMMER E, Kumar A, Zarychanski R (senior author/supervisor). Effectiveness of human
recombinant activated protein C for severe sepsis and septic shock in adult and pediatric patients:
Randomized clinical trial versus nonrandomized study. Critical Care Medicine. 2013;7:e139-40
[Author Reply]. PMID: 23774364
46. Zarychanski R, Turgeon AF, Abou-Setta AM. Meta-analyses of hydroxyethyl starch for
volume resuscitation. Journal of the American Medical Association/JAMA. 2013;309:2209 [Author
Reply]. PMID: 23736723
45. DENNIS J, Ramsay T, Turgeon AF, Zarychanski R (senior author/supervisor). Helmet
Legislation and admissions to hospital for cycling related head injuries in Canadian provinces and
Ryan Zarychanski
territories: interrupted time series analysis. British Medical Journal/BMJ. 2013;346:f2674. PMID:
23674137
44. Mercier E, Boutin A, Lauzier F, Fergusson DA, Simard JF, Zarychanski R, Moore L, McIntyre
LA, Archambault P, Lamontagne F, Légaré F, Randell E, Nadeau L, Rousseau F, Turgeon AF.
Predictive value of S-100ß protein for prognosis in patients with moderate and severe traumatic brain
injury: A systematic review and meta-analysis. British Medical Journal/BMJ. 2013;346:f1757.
PMID: 23558282
43. Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC,
Fergusson DA. Association of hydroxyethyl starch administration with mortality and acute kidney
injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.
Journal of the American Medical Association/JAMA. 2013 Feb 20;309(7):678-88. PMID: 23423413
42. Turgeon AF, Lauzier F, Burns KEA, Meade MO, Scales DC, Zarychanski R, Moore L, Zygun
DA, McIntyre LA, Kanji S, Hébert PC, Murat V, Pagilarello G, Furgusson DA. Determination of
neurological prognosis and clinical decision-making in adult patients with severe traumatic brain
injury: A survey of Canadian intensivists, neurosurgeons and neurologists. Critical Care Medicine.
2013;41:1086-93. PMID: 23385104
41. Côte N, Turgeon AF, Lauzier F, Moore L, Scales DC, Bernard F, Zarychanski R, Burns KE,
Meade MO, Zygun D, Simard JF, Boutin A, Brochu JG, Fergusson DA. Factors associated with the
withdrawal of life-sustaining therapies in patients with severe traumatic brain injury: A multicenter
cohort study. Neurocrit Care. 2013;18:154-60. PMID: 23099846
40. RIMMER E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger RP, Sharma S,
Penner C, Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R
(senior author/supervisor), and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS)
Database Research Group. Activated protein C and septic shock. A propensity matched cohort
study. Critical Care Medicine. 2012;40:2974-2981. PMID: 22932397
39. Zhang L, Hiebert B, Zarychanski R, Arora RC, and the Cardiovascular Health Research in
Manitoba Investigator Group. Preoperative anemia does not increase the risks of early surgical
revascularization following myocardial infarction. Annals of Thoracic Surgery. 2013;95:542-547.
PMID: 22939451
38. Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, Rinehart J,
Gallagher PG. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary
xerocytosis. Blood. 2012;120(9):1908-1915. PMID: 22529292
37. Plante J, Turgeon AF, Vigneault L, Lauzier F, Moore L, Zarychanski R, Boutin A, Nicole PC,
Fergusson DA. Effect of systemic steroids on post-tonsillectomy bleeding and reinterventions: a
meta-analysis of randomized control trials. British Medical Journal/BMJ 2012;345:e5389. PMID:
22930703
36. Desjardins P, Turgeon AF, Tremblay MH, Lauzier F, Zarychanski R, Boutin A, Moore L,
McIntyre LA, English SW, Rigamonti A, Lacroix J, Fergusson DA. Hemoglobin levels and
Ryan Zarychanski
transfusions in neurocritically ill patients: a systematic review of comparative studies. Critical Care
2012;16(2):R54. PMID: 22471943
35. McIntyre L, Fergusson DA, Rowe B, Cook DJ, Arabi Y, Bagshaw SM, Emond M, Finfer S, FoxRobichaud A, Gray A, Green R, Hebert P, Lang E, Marshall J, Stiell I, Tinmouth A, Pagliarello J,
Turgeon AF, Walsh T, Worster A, Zarychanski R, for the Canadian Critical Care Trials Group.
The PRECISE RCT: Evolution of an early septic shock fluid resuscitation trial. Transfusion
Medicine Reviews. 2012;26:333-341. PMID: 22222146
34. McIntyre L, Fergusson DA, Cook DJ, Rowe BH, Bagshaw S, Easton D, Emond M, Finfer S,
Fox-Robichaud A, Gaudert C, Green R, Hebert PC, Marshall J, Rankin N, Stiell I, Tinmouth A,
Pagliarello J, Turgeon AF, Worster A, Zarychanski R, for the Canadian Critical Care Trials Group.
Fluid Resuscitation with 5% Albumin versus Normal Saline in Early Septic Shock
(PRECISE): A Pilot Randomized Controlled Trial. Journal of Critical Care. 2012;27:317.e1-6.
PMID: 22176806
33. Houston DS, Zarychanski R. Transfusion thresholds in high-risk patients after hip surgery. New
England Journal of Medicine/NEJM. 2012;366:1253 [Letter]. PMID: 22455422
32. SAEED M, Rubinger M, Ahsanuddin A, Morales C, Penner B, Robinson D, Zarychanski R
(senior author/supervisor). If at first you don’t succeed: Try, try again. American Journal of
Hematology. 2012;87:295-7. PMID: 22086437
31. Olafson K, Ramsey C, Kumar A, STASIUK A, Ariano R, Siddiqui F, Wong D, Guinn A, Braun
J, Zarychanski R (senior author/supervisor). Sedation and analgesia usage in severe H1N1 (2009)
infection: A comparison to respiratory failure secondary to other infectious pneumonia. Annals of
Pharmacotherapy. 2012;46:9-20. PMID: 22170974
30. HOUSTON BL, Zelinski T, Israels SJ, Coghlan G, Chodirker BN, Gallagher PG, Houston DS,
Zarychanski R (senior author/supervisor). Refinement of the hereditary xerocytosis locus on
chromosome 16q in a large Canadian kindred. Blood Cells, Molecules and Diseases.
2011;47(4):226-231. PMID: 21944700
29. Hayani O, Al-Beihany A, Chou A, Zarychanski R, Kharaba A, Baxter A, Petal R, Allan D.
Impact of critical care outreach on hematopoietic stem cell transplant recipients: a cohort study.
Bone Marrow Transplantation. 2011;46:1138-1144. PMID: 20972465
28. Zarychanski R. From mice to men: Treating sepsis with heparin. Critical Care Medicine.
2011;39:1225-6 [Editorial]. PMID: 21610590
27. Rajasekhar A, Gowing R, Zarychanski R, Arnold D, Lim W, Crowther M, Lottenberg R.
Survival of trauma patients after massive red blood cell transfusion using a high or low red blood
cell to plasma transfusion ratio. Critical Care Medicine. 2011;39(6):1507-13. PMID: 21336132
26. Vigneault L, Turgeon AF, Côté D, Lauzier F, Zarychanski R, Moore L, McIntyre LA, Nicole
PC, Fergusson DA. Perioperative intravenous lidocaine infusion for postoperative pain control: a
Ryan Zarychanski
meta-analysis of randomized controlled trials. Canadian Journal of Anesthesia. 2011;58:22-37.
PMID: 21061107
25. Kumar A, Zarychanski R, Light B, Parrillo JE, Maki D, Simon D, Laporta D, Lapinsky S, Ellis
P, Mirzanejad Y, Martinka G, Keenan S, Wood G, Arabi Y, Feinstein D, Kumar A, Dodek P,
Kravetsky L, Doucette S; the Cooperative Antimicrobial Therapy of Septic Shock (CATSS)
Database Research Group. Early combination antibiotic therapy yields improved survival compared
to monotherapy in septic shock: A propensity-matched analysis. Critical Care Medicine.
2010;38(9):1773-1785. PMID: 20639750
24. DENNIS J, Potter B, Ramsay T, Zarychanski R (senior author/supervisor). The effects of
provincial bicycle helmet legislation on helmet use and recreational bicycle ridership in Canada.
Injury Prevention. 2010;16(4):219-24. PMID: 20587815
23. OLUYOMI-OBI T, Avery L, Schneider C, Kumar A, Lapinsky S, Menticoglou S, Zarychanski
R (senior author/supervisor). Perinatal and maternal outcomes in critically ill obstetrics patients with
pandemic H1N1 Influenza A. Journal of Obstetrics and Gynaecology Canada. 2010;32(5):443–447.
PMID: 20500952
22. Sood MM, Rigatto C, Zarychanski R, Komenda P, Sood AR, Bueti J, Reslerova M, Roberts D,
Mojica J, Kumar A. Acute kidney injury in critically ill patients infected with 2009 pandemic
influenza A(H1N1): Report for a Canadian Province. The American Journal of Kidney Disease.
2010;55:848-55. PMID: 20303633
21. Ariano RE, Sitar DS, Zelenitsky SA, Zarychanski R, Pisipati A, Ahern A, Kanji S, Rello J,
Kumar A. Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with
pandemic (H1N1) influenza. Canadian Medical Association Journal/CMAJ. 2010;182(4):357-363.
PMID: 20159892
20. Zarychanski R, Stuart TL, Kumar A, Doucette S, Elliott L, Kettner J, Plummer FA. Correlates
of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. Canadian
Medical Association Journal/CMAJ. 2010;182(3):257-264. PMID: 20093297
19. Freed DH, Henzler D, White CW, Fowler R, Zarychanski R, Hutchison J, Arora RC, Manji RA,
Legare JF, Drews T, Veroukis S, Kesselman M, Guerguerian AM, Kumar A for the Canadian
Critical Care Trials Group. Extracorporeal lung support for patients who had severe respiratory
failure secondary to influenza A (H1N1) 2009 infection in Canada. Canadian Journal of
Anaesthesia. 2010;57(3):240-7. PMID: 20082167
18. Houston DS, Zarychanski R. Dabigatran versus warfarin in patients with atrial fibrillation.
New England Journal of Medicine/NEJM. 2009;361(27):2671 [Letter]. PMID: 20042760
17. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S,
Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern S, Smith O, Siddiqui F, Jouvet P,
Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Sing J, Karachi T,
Wiebe K3, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler R, Canadian
Ryan Zarychanski
Critical Care Trials Group H1N1 Collaborative, on behalf of the Canadian Critical Care Trials
Group. Critically ill patients with 2009 influenza A (H1N1) infection in Canada.
Journal of the American Medical Association/JAMA. 2009:302(17);1872-1879. PMID: 19822627
16. Smetanin P, Stiff D, Kumar A, Kobak P, Zarychanski R, Simonsen N, Plummer FA. Potential
ICU Ventilator Demand/Capacity Mismatch due to Novel soH1N1 in Canada. Canadian Journal of
Infectious Diseases and Medical Microbiology. 2009;20(4):e115-e123. PMID: 21119787
15. Zarychanski R, Turgeon AF, Fergusson DA, Cook DJ, Hébert PC, Bagshaw SM, Monsour D,
McIntyre. Renal outcomes and mortality following hydroxyethyl starch resuscitation of critically ill
patients: systemic review and meta-analysis of randomized trials. OPEN Medicine. 2009;3(4):E196209. PMID: 21688756
14. Ahmad S, Tejuja A, Newman KD, Zarychanski R, Seely AJ. Clinical review: a review and
analysis of heart rate variability and the diagnosis and prognosis of infection. Critical Care.
2009;13(6):232. PMID: 20017889
13. Gin A, Kumar A, Zarychanski R, Honcharik N. Increased sedative and antibiotic use in H1N1
ICU Patients. Canadian Medical Association Journal/CMAJ. 14 Sept 2009 [Letter].
12. KUMAR K, Zarychanski R, Bell DD, Manji R, Zivot J, Menkis A, Arora R on behalf of the
Cardiovascular Health Research in Manitoba Investigator Group (CHaRM) Investigator Group.
The Impact of Twenty-Four Hour In-House Intensivists on a Dedicated Cardiac Surgery Intensive
Care Unit. Annals of Thoracic Surgery. 2009;88(4):1153-1161. PMID: 19766800
11. Zarychanski R, Ariano R, Paunovic B, Bell D. Historical perspectives in critical care medicine:
blood transfusion, intravenous fluids, inotropes/vasopressors, and antibiotics. Critical Care Clinics.
2009;25(1):201-220 [Review]. PMID: 19268803
10. Zarychanski R, Doucette S, Fergusson D, Roberts D, Houston DS, Sharma S, Gulati H, Kumar
A. Early intravenous unfractionated heparin and mortality in septic shock. Critical Care Medicine.
2008;36(11):2973-79. PMID: 18824906
9. Zarychanski R, Houston DS. Anemia of chronic disease: a harmful disorder or an adaptive,
beneficial response? Canadian Medical Association Journal/CMAJ. 2008;179(4):333-7 [Review].
PMID: 18695181
8. Zarychanski R, Dhaliwal D. Rates of colorectal cancer screening. Canadian Medical
Association Journal/CMAJ. 2008;178(11):1465 [Author reply]. PMID: 18490644
7. Zarychanski R, Turgeon AF, McIntyre L, Fergusson DA. Erythropoietin-receptor agonists in
critically ill patients: a meta-analysis of randomized controlled trials. Canadian Medical Association
Journal/CMAJ. 2007;177(7): 725-734. PMID: 17823140
6. Zarychanski R, Chen Y, Bernstein C, Hébert PC. Frequency of colorectal cancer screening and
the impact of family physicians on screening behaviour. Canadian Medical Association
Journal/CMAJ. 2007;177(6); 593-7. PMID: 17846441
Ryan Zarychanski
5. Zarychanski R, Wlodarczyk K, Ariano R, Bow E. Pharmacokinetic interaction between
methotrexate and piperacillin/tazobactam resulting in prolonged toxic concentrations of
methotrexate. Journal of Antimicrobial Chemotherapy. 2006; 58(1):228-30. PMID: 16717053
4. Zarychanski R, Elphee E, Walton P, Johnston J. Osteonecrosis of the jaw associated with
pamidronate therapy. American Journal of Hematology. 2006;81(1):73-75. PMID: 16369966
3. Zarychanski R, Houston DS. Plasma homocysteine concentration is not associated with
activated protein C resistance in patients investigated for hypercoagulability. Thrombosis &
Haemostasis. 2004;91(6):1115-22. PMID: 15175797
2. Becker ML, Suchak AA, Wolfe JN, Zarychanski R, Kabani A, Nicolle LE. Mycobacterium
neoaurum bacteremia in a hemodialysis patient. Canadian Journal of Infectious Diseases.
2003;14(1):45-48. PMID: 18159425
1. Veinot JP, Mai KT, Zarychanski R. Chloroquine related cardiac toxicity. Journal of
Rheumatology. 25(6):1221-1225, 1998. PMID: 9632091
Ryan Zarychanski
BOOK CHAPTERS
5. HOUSTON BL, Houston DS, Zarychanski R (senior author/supervisor). (December 2014)
Approach to anemia:. In: eLS 2014, John Wiley & Sons Ltd: Chichester http://www.els.net/
4. Zarychanski R, Rimmer E, Houston DS. (September 2012) Anemia: Adaptive mechanisms and
consequences. In: eLS 2012, John Wiley & Sons Ltd: Chichester http://www.els.net/ [DOI:
10.1002/9780470015902.a0002157.pub2].
3. Zarychanski R, Turgeon A, Hebert PC, Tinmouth A. Transfusion. In: Core topics in
cardiothoracic critical care. Klein A, Vuylsteke A, Nashef S, editors. Cambridge University Press,
2008.
2. Darovic G, Zarychanski R, Kumar A. Swan Ganz. Catheterization. In: Hemodynamic
Monitoring: Invasive and Noninvasive Clinical Application. Darovic G, editor. Philadelphia:
Saunders, 2007.
1. Zarychanski R. Collaborative Reviewer. The Year Book of Critical Care Medicine.
Eds. Dellinger P, Parrillo J. Philadelphia: Elsevier Mosby, 2006.
Ryan Zarychanski
SUPERVISED STUDENT PUBLICATIONS
Published
RIMMER E, Houston BL, Cook DJ, Turgeon AF, Kumar A, Friesen C, Houston DS, Abou-Setta
AM, Zarychanski R* (*senior author/supervisor). The efficacy and safety of plasmapheresis in sepsis
and septic shock: A systematic review and meta-analysis. Critical Care. 2014, 18:699
DOI: 10.1186/s13054-014-0699-2
CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). Methotrexate and
trimethoprim-sulfamethoxazole: Toxicity from this combination continues to occur. Canadian
Family Physician. 2014:60(1):53-6. PMID: 24452563
AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, Abou-Setta
AM, Zarychanski R (senior author/supervisor). Probiotic Supplementation During Pregnancy or
Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis. British
Medical Journal/BMJ. 2013;347:f6471. PMID: 24304677
YAMAMOTO J, Dostmohamed H, Schacter I, Ariano RE, Lewis B, Knoll C, Katz P, Zarychanski
R. (senior author/supervisor). Preoperative therapeutic apheresis for severe medically refractory
amiodarone-induced thyrotoxicosis: A case report. Journal of Clinical Apheresis. 2014;29(3):16870. PMID: 24265247
RIMMER E, Kumar A, Zarychanski R* (*senior author/supervisor). Effectiveness of human
recombinant activated protein C for severe sepsis and septic shock in adult and pediatric patients:
Randomized clinical trial versus nonrandomized study. Critical Care Medicine. 2013;7:e139-40
[Author Reply]. PMID: 23774364
DENNIS J, Ramsay T, Turgeon AF, Zarychanski R (senior author/supervisor). Helmet Legislation
and admissions to hospital for cycling related head injuries in Canadian provinces and territories:
interrupted time series analysis. British Medical Journal/BMJ. 2013;346:f2674. PMID: 23674137
RIMMER E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger RP, Sharma S, Penner C,
Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R (senior
author/supervisor), and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database
Research Group. Activated protein C and septic shock. A propensity matched cohort study. Critical
Care Medicine. 2012;40:2974-2981. PMID: 22932397
SAEED M, Rubinger M, Ahsanuddin A, Morales C, Penner B, Robinson D, Zarychanski R (senior
author/supervisor). If at first you don’t succeed: Try, try again. American Journal of Hematology.
2012;87:295-7. PMID: 22086437
Olafson K, Ramsey C, Kumar A, STASIUK A, Ariano R, Siddiqui F, Wong D, Guinn A, Braun J,
Zarychanski R (senior author/supervisor). Sedation and analgesia usage in severe H1N1 (2009)
infection: A comparison to respiratory failure secondary to other infectious pneumonia. Annals of
Pharmacotherapy. 2012;46:9-20. PMID: 22170974
Ryan Zarychanski
HOUSTON BL, Zelinski T, Israels SJ, Coghlan G, Chodirker BN, Gallagher PG, Houston DS,
Zarychanski R (senior author/supervisor). Refinement of the hereditary xerocytosis locus on
chromosome 16q in a large Canadian kindred. Blood Cells, Molecules and Diseases.
2011;47(4):226-231. PMID: 21944700
DENNIS J, Potter B, Ramsay T, Zarychanski R (senior author/supervisor). The effects of provincial
bicycle helmet legislation on helmet use and recreational bicycle ridership in Canada. Injury
Prevention. 2010;16(4):219-24. PMID: 20587815
OLUYOMI-OBI T, Avery L, Schneider C, Kumar A, Lapinsky S, Menticoglou S, Zarychanski R
(senior author/supervisor). Perinatal and maternal outcomes in critically ill obstetrics patients with
pandemic H1N1 Influenza A. Journal of Obstetrics and Gynaecology Canada. 2010;32(5):443–447.
PMID: 20500952
KUMAR K, Zarychanski R, Bell DD, Manji R, Zivot J, Menkis A, Arora R on behalf of the
Cardiovascular Health Research in Manitoba Investigator Group (CHaRM) Investigator Group.
The Impact of Twenty-Four Hour In-House Intensivists on a Dedicated Cardiac Surgery Intensive
Care Unit. Annals of Thoracic Surgery. 2009;88(4):1153-1161. PMID: 19766800
Ryan Zarychanski
ABSTRACTS/POSTERS/ORAL PRESENTATIONS
72. Laflamme M, Haghbayan H, Boutin A, Shemilt M, Douville V, Lauzier F, Moore L,
Zarychanski R, English S, Turgeon AF. Statins and Delayed Cerebral Ischemia in Patients with
Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis. Neurocritical Care
Society. Scottsdale, Arizona, 2015 [Poster].
71. BEDNARCZYK JM, Fridfinnson JA, Kumar A, Blanchard L, Rabbani R, Bell D, Funk D,
Turgeon AF, Abou-Setta AM, Zarychanski R. (senior author/supervisor). Incorporating fluid
responsiveness into goal-directed therapy – does it affect outcome? A systematic review and metaanalysis. SMACC (Social Media and Critical Care). Chicago, U.S.A. June 24, 2015 [Poster].
70. Dawe DE, Christiansen D, Zarychanski R, Abou-Setta AM, Ellis PM, Swaminath A, Rothney J,
Rabbani R, Mahmud S. Chemoradiotherapy versus radiotherapy alone in elderly patients with Stage
III non-small cell lung cancer: a systematic review. World Conference on Lung Cancer. Sydney,
Australia. October 27, 2015. [Poster]
69. Reid AE, Fiander M, Rabbani R, MacKay DS, McGavock J, Wicklow B, Abou-Setta AM,
Zarychanski R, Azad MB. Do non-nutritive sweeteners have adverse effects on metabolic health in
infants and children? A systematic review of randomized controlled trials and prospective cohort
studies. Canadian Nutrition Society. 2015 Annual Conference. Winnipeg, Canada. May 28, 2015
[Poster].
68. BORESKI P, Arora R, Hiebert B, Garland A, Doucette S, Zarychanski R. (senior
author/supervisor). Massive transfusion: Impact of plasma to red cell ratio in cardiothoracic surgery.
CancerCare Research Day. CancerCare Manitoba. Winnipeg, Canada. April 21, 2015. [Oral
Presentation]
67. Perija B, Kotb R, Rimmer E, Houston DS, Zarychanski R. (senior author/supervisor). Acquired
hemophilia presenting with spontaneous bleeding. Department of Internal Medicine Research Day.
University of Manitoba. Winnipeg, Canada. April 21, 2015. [Poster]
66. Shemilt M, Laforest JF, Lauzier F, Boutin A, Fergusson DA, Zarychanski R, Moore L,
McIntyre LA, Nadeau L, Turgeon AF. Prognostic value of Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) in patients with moderate or severe traumatic brain injury: A systematic review.
International Symposium on Intensive Care and Emergency Medicine. Brussels, Belgium. March
2015 [Poster].
65. Zarychanski R, Abou-Setta AM, Kanji S, Turgeon AF, Kumar A, Houston DS, Rimmer E,
Houston BL, McIntyre L, Fox-Robichaud AE, Hébert PC, Cook DJ, Fergusson DA, for the Canadian
Critical Care Trials Group. The efficacy and safety of heparin in patients with sepsis: A systematic
review and meta-analysis. International Symposium on Intensive Care and Emergency Medicine.
Brussels, Belgium. March 2015 [Poster].
64. Whitney D, Klassen K, Holmqvist, M, Bailly M, Abou-Setta, AM, Friesen C, Zarychanski R.
(senior author/supervisor). Effectiveness & Safety of Videoconference Psychotherapy for PTSD: A
Ryan Zarychanski
Systematic Review and Meta-analysis. Canadian Institute for Military and Veteran Health Research
Forum. Toronto, Canada. November, 2014.
63. Singal D, Menard C, Friesen C, Zarychanski R, Hanlon-Dearman A, Chudley A, Brownell M,
Abou-Setta AM. A Systematic Review of Treatments for Children and Adolescents with Fetal
Alcohol Spectrum Disorder. Living Well: FASD and Mental Health Conference. Winnipeg, Canada.
November 2014. [Poster].
62. Lalonde G, Boutin A, Desjardins P, Lauzier F, Moore L, Zarychanski R, Fergusson DA,
Turgeon AF. Outcome measures in severe traumatic brain injury: a systematic review. Canadian
Critical Care Forum. Toronto, Canada, November 2014 [Poster].
61. Lodewyks C, Bednarczyk J, Mooney O, Zarychanski R, Singal R. Extracorporeal membrane
oxygenation, pulmonary embolectomy, and right ventricular assist device for massive pulmonary
embolus: a case report and literature review. Canadian Critical Care Forum. Toronto, Canada,
November 2014 [Poster].
60. HURRIE D, Graham J, Rimmer E, Abou-Setta A, Bernstein CN, Houston DS, Zarychanski R.
(senior author/supervisor). Efficacy of iron replacement therapy on fatigue and work capacity in nonanemic adults with iron depletion: a systematic review of randomized controlled trials. International
Calgary Running Symposium. Calgary, Canada August 2014 [Poster].
59. Singal D, Menard C, Friesen C, Zarychanski R, Hanlon-Dearmnan A, Chudley A, Brownell M,
Abou-Setta AM. A systematic review of treatments for children and adolescents with fetal alcohol
spectrum disorders. Living well: FASD and Mental Health Conference. Winnipeg, Canada.
November 2014 [Oral Presentation].
58. Tetrault S, Boutin A, Chasse M, Leblanc G, Shemilt M, Lauzier F, Zarychansk R, Fergusson
DA, Turgeon AF. Withdrawal of life-sustaining therapy in clinical trials in critical care: a systematic
review. European Society of Intensive Care Medicine, Barcelona, Spain. September 2014. [Poster
Presentation]
57. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Shemilt M, Moore L, Zarychanski R,
Fergusson DA, Turgeon AF. The Prognostic Value of Magnetic Resonance Imaging in Moderate and
Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. European Society of
Intensive Care Medicine, Barcelona, Spain. September 2014. [Poster Presentation]
56. Laflamme M, Boutin A, Fergusson DA, Desjardin P, Moore L, Lauzier F, Lamontagne F,
Haghbayan H, Lacroix J, Shemilt M, Zarychanski R, Turgeon AF. Red Blood Cell Transfusion in
Acute Cerebral Injuries: a Systematic Review of Preclinical Studies. European Society of Intensive
Care Medicine, Barcelona, Spain. September 2014. [Poster Presentation]
55. Ashcroft RC, Ahsan W, Zarychanski R, Kumar A. Time to thrombolysis and anticoagulation in
pulmonary embolism: A quality improvement study. Resident Research Day, University of
Manitoba, Winnipeg, MB, May 2014. [Poster]
Ryan Zarychanski
54. Zawadski D, Houston DS, Rimmer E, Zarychanski R. (senior author/supervisor). Coronary
bypass surgery in a patient with hemophilia A: The critical role of the nurse clinician. World
Hemophilia Congress. Melbourne, Australia. May 2014 [Poster].
53. Abou-Setta AM, Lix L, Klassen T, Zarychanski R. (senior author/supervisor). Author bias can
underestimate objective outcome measures in meta-analysis: An exploratory analysis.
Cochrane Canada Symposium. Ottawa, Canada. April 2014 [Oral Presentation].
52. RIMMER E, Houston BL, Cook DJ, Turgeon AF, Kumar A, Friesen C, Houston DS, Abou-Setta
AM, Zarychanski R (senior author/supervisor). The efficacy and safety of therapeutic apheresis in
sepsis and septic shock: A systematic review and meta-analysis. American Society of Hematology.
New Orleans, U.S.A. December 2013 [Poster].
51. Wittick H, Zarychanski R, Poeppl A, Houston DS, Houston BL, Banerji V. GDF15 Is not the
sole negative regulator of hepcidin in hereditary xerocytosis. American Society of Hematology.
New Orleans, U.S.A. December 2013 [Poster].
50. Asselin M, Lachance Y, Lalonde G, Boutin A, Shemilt M, Lauzier F, Moore L, Zarychanski R,
Archambault P, Lamontagne F, Fergusson DA, Turgeon AF. Long term functional outcome in adults
with severe TBI: A meta-analysis. Canadian Critical Care Forum. Toronto, Canada, November 2013
[Poster].
49. Haghbayan H, Boutin A, Laflamme M, Lauzier F, Schemilt M, Moore L, Zarychanski R,
Fergusson DA, Turgeon AF. Prognostic Value of Magnetic Resonance Imaging in Moderate and
Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Canadian Critical Care
Forum. Toronto, Canada, November 2013 [Poster].
48. Laflamme M, Boutin, A, Haghbayan H, Shemilt M, Lauzier F, Moore L, Zarychanski R,
Lacroix J, Lamontagne F, Fergusson DA, Desjardins P, Turgeon AF. Red Blood Cell Transfusion in
Acute Cerebral Injuries: a Systematic Review of Preclinical Studies. Canadian Critical Care Forum.
Toronto, Canada, November 2013 [Poster].
47. Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, English S, Zarychanski R, McIntyre L,
Lacroix J, Griesdale D, Fergusson DA, Desjardins P, Turgeon AF. Red blood cell transfusion in
patients with traumatic brain injury: a systematic review. Canadian Critical Care Forum. Toronto,
Canada, November 2013 [Poster].
46. MOONEY O, Bell D, Rimmer E, Houston DS, Zarychanski R (senior author/supervisor).
Nucleated red blood cells as an independent predictor of ICU mortality and ICU recidivism.
Resident Research Day, University of Manitoba, Winnipeg, MB, 2013. [Oral Presentation]
45. AZAD MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, Friesen C, AbouSetta AM, Zarychanski R (senior author/supervisor). Probiotic Supplementation During Pregnancy or
Infancy for the Prevention of Wheeze and Asthma: A Systematic Review and Meta-Analysis.
Canadian Society of Allergy and Clinical Immunology. Toronto, Canada, October 2013 [Poster].
44. FEDOROW CA, Pikaluk DR, Abou-Setta AM, Grocott HP, Zarychanski R (senior
Ryan Zarychanski
author/supervisor). Fibrinogen concentrate for perioperative bleeding: A systematic review and meta-
analysis. CancerCare Research Day, Winnipeg, MB, May 2013. [Oral Presentation]
43. YAMAMOTO J, Dostmohamed H, Schacter I, Katz P, Zarychanski R (senior author/supervisor).
Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced
thyrotoxicosis: A case report. CancerCare Research Day, Winnipeg, MB, 2013. [Poster]
42. Asselin M, Lachance Y, Lalonde G, Boutin A, 3Shemilt M, Moore L, Lauzier F, Zarychanski
R, Archambault P, Lamontagne F, Fergusson DA, Turgeon A. Long-term functional outcome in
adults with severe TBI: a meta-analysis. International Symposium on Intensive Care Medicine,
Brussels, Belgium, March 2013. [Poster]
41. Kumar K, Hiebert B, Zarychanski R, Grocott HP, Bell DD, Menkis AH, Arora RC. What is the
cost of better care for patients post-cardiac surgery? 24/7 in-house consultant staffing is a costeffective model. Canadian Cardiovascular Congress, Toronto, Ontario. October 2012 [Poster]
40. Lauzier F, Arnold D, Rabbat C, Heels-Ansdell D, Zarychanski R, Lopes R, Zytaruk N,
Crowther M, Cook DJ. Major Bleeding Epidemiology and Impact on Mortality in Medical-Surgical
Critically Ill Patients Receiving Thromboprophylaxis: A Cohort Study. Society of Critical Care
Medicine, San Juan, Puerto Rico, 2012. [Poster]
39. Hallet J, Lauzier F, Olivier M, Trottier V, Archambault P, Zarychanski R, Turgeon AF. The
liberal use of platelet transfusions in the acute phase of trauma resuscitation: A systematic review.
Canadian Surgery Forum. Calgary, AB, September 2012. [Poster].
38. MAKAR B, Weldon E, Lane D, Muirhead B, Doucette S, Webb A, Peters H, Strome T, Turgeon
A, Rimmer E, Fergusson DA, Kumar A, Houston DS, Zarychanski R (senior author/supervisor).
Hemostatic monitoring and maintenance of minimal hemostatic thresholds in massive transfusion.
CancerCare Research Day, Winnipeg, MB, May 2012. [Oral Presentation]
37. HOUSTON BL, Zarychanski R, Houston DS, Schultz V, Maksimova Y, Smith B, Rinehart J,
Gallagher PG (senior author/supervisor). Mutations in the mechanotransduction protein PIEZO1 are
associated with hereditary xerocytosis. CancerCare Research Day, Winnipeg, MB, May 2012. [Oral
Presentation]
36. HOUSTON BL, Abou-Setta A, Turgeon AF, McIntyre LA, Fergusson D, Zarychanski R (senior
author/supervisor). Mortality and renal outcomes associated with hydroxyethyl starch resuscitation in
critically ill patients: A systematic review and meta-analysis of randomized trials. CancerCare
Research Day, Winnipeg, MB, May 2012. [Poster]
35. RIMMER E, Zarychanski R, Roland K, Houston D (senior author/supervisor). Adequacy of Bone
Marrow Trephine Biopsy in a tertiary care centre. CancerCare Research Day, Winnipeg, MB, May
2012. [Poster]
34. Turgeon AF, Lauzier F, Boutin A, Côte N, Zarychanski R, Fowler R, Scales D, Meade M,
Burns K, Bernard F, Zygun D, Moore L, Fergusson DA. Potential association of gender with
mortality and withdrawal of life-sustaining therapies in patients with severe TBI: a Canadian
Ryan Zarychanski
multicentre cohort study. European Society of Intensive Care Medicine. Lisbon, September 2012.
[Poster]
33. Zarychanski R, Lauzier F, Turgeon A, Marshall J, Nates J, Cox M, Arabi Y, Qushmaq I,
Zytaruk N, Cook D. VTE Risk Factors in Medical-Surgical ICU Patients. Society of Critical Care
Medicine, Houston, TX, 2012. [Poster]
32. Zarychanski R, Lim W, Rocha M, McIntyre L, Lamontagne F, Dodek P, Pai M, Cooper D,
Alhashemi J, Zytaruk N. Do Statins Influence DVT Risk in the Critically Ill Patients? Society of
Critical Care Medicine, Houston, TX, 2012. [Poster]
31. MAKAR B, Weldon E, Webb A, Peters H, Turgeon A, Houston D, Rimmer E, Kumar A,
Fergusson D, Zarychanski R (senior author/supervisor). Frozen plasma to red blood cell ratio and
mortality in patients requiring massive transfusion. Society of Critical Care Medicine, Houston, TX,
2012. [Poster]
30. RIMMER E, Kumar A, Turgeon A, Makar B, Houston D, Zarychanski R (senior
author/supervisor). Clinical Use of Activated Protein C in Septic Shock: Results from a Multinational
Cohort. Society of Critical Care Medicine, Houston, TX, 2012. [Poster]
29. RIMMER E, Kumar A, Houston D, Doucette S, Zarychanski R (senior author/supervisor).
Activated Protein C and Septic Shock: A Propensity-Matched Cohort Study. Society of Critical Care
Medicine, Houston, TX, 2012. [Oral Presentation]
28. Zhang L, Hiebert B, Zarychanski R, Arora R. The Complex Relationship Between Preoperative
Hemoglobin And The Risks Of Cardiac Surgery: An Age- And Gender-Based Analysis.
Society of Thoracic Surgeons, Fort Lauderdale, FL, January 2012. [Oral Presentation]
27. HOUSTON BL, Zelinski T, Houston DS, Israels SJ, Coghlan G, Chodirker BN, Gallagher P,
Zarychanski R (senior author/supervisor). Genetic Linkage of the Dehydrated Hereditary
Stomatocytosis Locus to Chromosome 16 in Two Kindreds and Refinement of the Candidate Gene
Region to 16q24.2 – 16qter. American Society of Hematology Annual Meeting, San Diego, CA,
December 2011. [Poster]
26. Desjardins, P, English S, Zarychanski R, Lauzier F, Fergusson DA, Lacroix, J, Moore L,
McIntyre LA, Turgeon AF. Effects of hemoglobin levels and transfusions on clinical outcomes of
neurocritical care patients: a systematic review of comparative studies. Neuorcritical Care Society,
Montreal, QC, 2011. [Poster]
25. MAKAR B, Weldon E, Lane D, Muirhead B, Turgeon A, Strome T, Webb A, Peters H,
Zarychanski R (senior author/supervisor). Practice Patterns in Massively Transfused Patients. Faculty
of Medicine Resident Research Day, Winnipeg, MB, January 2011. [Oral Presentation]
24. DESAUTELS A, Kirkpatrick I, Szwajcer D, Williams G, Zarychanski R (senior
author/supervisor). Diagnosis of acute promyelocytic leukemia in the absence of peripheral
hematologic abnormalities. Internal Medicine Research Day, Winnipeg, MB, 2011. [Poster]
Ryan Zarychanski
23. PAUL JT, Rimmer E, Lamba K, Morales C, Zarychanski R (senior author/supervisor). Adverse
events associated with bone marrow biopsy in a resident training program: First do no harm.
Internal Medicine Research Day, Winnipeg, MB, 2011. [Poster]
22. SAEED M, Rubinger M, Ahsanuddin A, Morales C, Penner B, Robinson D, Zarychanski R
(senior author/supervisor). Hodgkin Lymphoma associated with Evan’s syndrome, pure red cell
aplasia and systematic inflammatory response. CancerCare Research Day, Winnipeg, MB, 2011.
[Poster]
21. CUDMORE JA, Seftel MD, Sisler JJ, Zarychanski R (senior author/supervisor). First do no harm:
Trimethoprim/sulfamethoxazole induced pancytopenia and mucositis in a patient on long term, low
dose methotrexate. CancerCare Research Day, Winnipeg, MB, 2011. [Poster]
20. RIMMER E, Kumar A, Doucette S, Zarychanski R (senior author/supervisor), and The Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Activated
protein C and septic shock. A propensity matched cohort study. CancerCare Research Day,
Winnipeg, MB, 2011. [Oral Presentation]
19. HOUSTON BL, Zelinski T, Israels SJ, Coghlan G, Chodirker BN, Houston DS, Zarychanski R
(senior author/supervisor). Phenotypic and genotypic evaluation of a family with hemolytic anemia.
CancerCare Research Day, Winnipeg, MB, May 2011. [Oral Presentation]
18. Heels-Ansdell D, Zytaruk N, Meade M, Mehta S, Hall R, Zarychanski R, Rocha M, Lim W,
Lamontagne F, McIntyre L, Dodek P, Vallance S, Davies A, Cooper J, Cook DJ for the PROTECT
Investigators, CCCTG and ANZICS CTG. Pulmonary Embolism In Medical-Surgical ICU Patients.
International Symposium of Intensive Care and Emergency Medicine, Brussels, Belgium, March
2011. [Poster]
17. Jung J, Fowler R, Long J, Zarychanski R, Rodin R, Cook D, Jouvet P, Marshall J, Kumar A, On
behalf of the ICU-Flu Investigators. 2009-2010 H1N1-Related Critical Illness among Aboriginal and
Non-Aboriginal Canadians. American Thoracic Society, Denver, CO, May 2011. Am J Resp Crit
Care Med 2011;16731:B49 [Poster]
16. HOUSTON BL, Houston DS, Israels SJ, Coghlan G, Chodirker BN, Zelinski T, Zarychanski R
(senior author/supervisor). Phenotypic evaluation of a family cohort with haemolytic anaemia.
American Society of Hematology, Orlando, FL, 2010. [Poster]
15. KUMAR K, Gulati H, Hiebert B, Zarychanski R, Grocott H, Jacobsohn E, MacKenzie S, Zivot
J, Menkis A, Arora R. The Hybrid cardiac surgical ICU: The impact of daytime cardiac
anesthesiologist & 24-hour in-house intensivist staffing on outcomes after ultra-fast-track cardiac
anesthesia. Society of Cardiovascular Anesthesiology, New Orleans, LA, April 2010. [Poster]
14. McIntyre LA, Turgeon A, Green R, Fox Robichaud AE, Fergusson D, Tinmouth A, Cook DJ,
Hebert PC, Marshall J, Finfer S, Bagshaw S, Zarychanski R, Pagliarello J, Stiell I, Worster A,
Rowe B, Emond M, Rankin N for the Canadian Critical Care Trials Group. The PRECISE fluid
resuscitation pilot randomized controlled trial: Study design and preliminary feasibility results.
American Thoracic Society, New Orleans, LA. May 2010. [Poster]
Ryan Zarychanski
13. Zarychanski R, Turgeon AF, Hebert PC, Cook DJ, Tinmouth A, Kumar A, McIntyre LA,
Fergusson DA. The use of anticoagulants in severe sepsis and septic shock: A national survey of
critical care physicians. Society of Critical Care Medicine, Miami, FL, 2010. [Poster]
12. Turgeon AF, Lauzier F, Burns K, Zarychanski R, Meade MO, McIntryre LA, Zygun DA, Kanji
S, Moore L, Fergusson DA. Determining neurological prognosis in ICU patients with severe
traumatic brain injury: A survey of Canadian neurosurgeons. Society of Critical Care Medicine,
Miami, FL, 2010. [Poster]
11. Mercier E, Turgeon AF, Simard JF, Lauzier F, Zarychanski R, Moore L, Nadeau L, Fergusson
DA. Predictive value of S-100ß protein for prognosis in patients with moderate and severe TBI : A
systematic review and meta-analysis. Society of Critical Care Medicine, Miami, FL, 2010. [Poster]
10. KUMAR K, Hiebert B, Zarychanski R, Bell D, Singal R, Manji R, Zivot J, Menkis A, Arora
RC , on behalf of the Cardiovascular Health Research in Manitoba Investigator Group (CHaRM)
Investigator Group. Does the use of twenty-four hour, in-house intensivist staffing model in a
dedicated cardiac intensive care unit impact outcomes for prolonged stay (>48 hours) patients?
Society of Critical Care Medicine, Miami, FL, U.S.A., 2010. [Oral Presentation]
9. Southon J, Zytaruk N, Lim WP, Zarychanski R, Rocha M, D Heels-Ansdell, G Guyatt, Cook D,
S Walter, for the PROTECT Investigators (clinicaltrials.gov NCT00182143) & Canadian Critical
Care Trials Group. Venous thrombosis adjudication for a thromboprophylaxis trial. Hamilton
Research Day, Hamilton, ON, 2009. [Poster]
8. Zarychanski R, Turgeon AF, Fergusson DA, Cook DJ, Hébert PC, Bagshaw SM, Monsour D,
McIntyre. Renal outcomes following hydroxyethyl starch resuscitation: A meta-analysis of
randomized trials. European Society of Intensive Care Medicine, Lisbon, Portugal, September 2008.
[Oral Presentation]
7. Turgeon A, Lauzier F, Burns K, Fergusson D, Meade M, Zygun D, Scales D, Zarychanski R, Moore
L, Kanji S, McIntyre L, Pagliarello J, Hébert P, the Canadian Critical Care Trials Group. Determining
neurological prognosis in patients with severe traumatic brain injury: a survey of Canadian intensivists.
International Symposium on Intensive Care Medicine, Brussels, Belgium, March 2008. [Poster]
6. Arora RC, Zarychanski R, Bell D, Zivot J, Lee J, Kumar K, Zhang L, Menkis A. The Manitoba
model of post-operative cardiac surgery intensive care. Toronto Critical Care Medicine Symposium,
Toronto, ON, April 2007. [Oral Presentation]
5. KUMAR K, Zhang L, Zarychanski R, Bell D, Lee J, Menkis A, Arora RC. Dedicated cardiac
surgery intensive care unit: 24 hour in-house intensivists and transfusion practices. American
College of Surgeons Manitoba Chapter Meeting. Winnipeg, MB, 2007. [Oral Presentation]
4. Zarychanski R, Turgeon A, Fergusson DA, Hébert PC. The use of erythropoietin in critically ill
patients. A meta-analysis of published trials. Toronto Critical Care Medicine Symposium. Toronto,
ON, 2007. [Oral Presentation]
Ryan Zarychanski
3. Zarychanski R, Gulati H, Roberts D, Houston DH, Kumar A. Systemically administered heparin
is associated with increased survival in patients diagnosed with septic shock. Toronto Critical Care
Medicine Symposium, Toronto, ON, 2005. [Oral Presentation]
2. Zarychanski R, Elphee E, Walton P, Johnston J. Osteonecrosis of the jaw associated with
pamidronate therapy. American Society of Hematology, San Diego, CA, December 2004. [Poster]
1. Zarychanski R, Houston DS. Plasma homocysteine concentration is not associated with
activated protein C resistance in patients investigated for hypercoagulability. American Society of
Hematology, San Diego, CA, December 2003. [Poster]
Ryan Zarychanski
RESEARCH ACTIVITIES
MAJOR RESEARCH PROGRAM:
Efficacy and Safety of Unfractionated Heparin in Septic Shock
Observational study – manuscript published
Meta-analysis – manuscript published
National survey – manuscript in preparation
Pilot randomized controlled trial – Completed
LOCAL PI AND EXECUTIVE STEERING COMMITTEES
2009-PRESENT
(ABLE) Age of Blood Evaluation Study.
PIs: Jacques Lacroix, Dean Fergusson, and Alan Tinmouth
Role: Site PI
Status: Enrolling (SBGH and HSC)
2009-PRESENT
(SOME) Screening for Occult Malignancy in Patients with Idiopathic Venous
Thromboembolism: an Open Randomized Controlled Trial using
Comprehensive Abdomen/Pelvis Computed Tomography.
PI – Marc Carrier
Role: Executive Steering Committee member and site PI
Status – Completed/Published
2010-2011
(PUCS): Plasma Utilization in Cardiac Surgery A Multicentre Observational
Study
PI - Alan Tinmouth
Role: Executive Steering Committee member and local site PI.
Status: Completed
2010-2013
(WAVE) Weaning and Variability Evaluation.
PI – Andrew Seely
Role: Executive Steering Committee member and local site PI
Status: Completed/Published
2008 – 2009
(PRECISE pilot) Five Percent Albumin Vs Normal Saline as Fluid
Resuscitation Strategies for the Management of Early Suspected Septic Shock.
PI – Lauralyn McIntyre
Role: Local site PI.
Status: Completed/Published
Ryan Zarychanski
Data Safety and Monitoring Committees
2008 – 2012
(REDOXS) Reducing Deaths Due to Oxidative Stress: A randomized trial of
glutamine and anti-oxidant supplementation in critically ill patients. PI – Darren
Heyland
Role: DSMB Member
Status: Enrolling
Adjudication Committees
2008 – 2010
(PROTECT) Prophylaxis of Thromboembolism in Critical Care Trial.
PI – Deborah Cook
Role: Outcomes Adjudication Committee member
Status: Study completed/published in New England Journal of Medicine
Other Research Programs
2010 – Present
Phenotypic and genotypic evaluation of a Manitoban kindred with hemolytic
anemia
PI – Ryan Zarychanski
Co-investigators: Brett Houston, Donald Houston, Sara Israels, Terry
Zelinski, Bernie Chodirker
Status – DNA linkage analysis has been published in BCMD. The discovery
of the gene mutation has been published in Blood. Iron regulation
studies are currently underway
2010 – Present
Bicycle Head Injuries and Helmet Legislation in Canada: Translation
knowledge into action
PIs – Jessica Dennis and Ryan Zarychanski (Supervisor)
Status – First manuscript (helmet legislation and bike ridership) published.
Second manuscript (helmet legislation and head injuries) published
2010 – Present
Processes of Care in Massive Transfusion
PIs – Ryan Zarychanski and Bryce Makar
Status – One systematic review has been published, and one observational
study is under revision. We have developed an evidence-informed massive
transfusion protocol (MTP), and are now developing and implementing
systems change to accommodate the Health Sciences Centre and St. Boniface
Hospital. The knowledge translation strategy will be accompanied by a
program evaluation study.
2012 – Present
Evaluation of bleeding and risk of bleeding in critically ill patients
PIs – Emily Rimmer and Ryan Zarychanski
Ryan Zarychanski
Status – The aim of this program is to a) develop a clinically useful bleeding
assessment tool that adjudicates the incidence and severity of bleeding
episodes among critically ill patients and to b) investigate risk factors for
bleeding in critically ill patients receiving anticoagulants.
2012 – Present
Efficacy and safety of fibrinogen concentrates in cardiac surgery
PIs – Christine Federow and Ryan Zarychanski
Status – The first two phases of this research program are a systematic review
and a National survey cardiac anaesthetists. This goal of this program is a
randomized clinical trial of fibrinogen concentrates in cardiac surgical
patients. The systematic review manuscript is currently under preparation;
the survey protocol is under development
RESEARCH PRESENTATION JUDGING
2013
2012
2012
BSc. (Med) research dissertations, University of Manitoba
Internal Medicine Resident Research Day, University of Manitoba
Research Day, CancerCare Manitoba
Ryan Zarychanski
HONOURS/ACHIEVEMENTS
2015
2015
2014
2013
2012
2006-2008
2006
2005-2006
2005
2005
2005
2004
2004
2003
2003
2003
2003
2000
1999
1998
1997-1998
1996-1997
1996
CFPC Continuing Professional Development (CPD) Award
College of Family Physicians of Canada, Ottawa, Canada. Award in recognition of
“Blood Day” CPD event for family physicians in Manitoba & Northwestern Ontario
Joe Doupe Memorial Lecture. University of Manitoba. September 3, 2015
Liam J. Murphy Young Investigator Award. Department of Internal Medicine,
University of Manitoba. November, 2014 ($30,000)
Nomination, Mentor of the Year
Royal College of Physicians & Surgeons of Canada
Research Citation Award, Society of Critical Care Medicine, Annual Congress
Houston, TX, 2012.
University of Ottawa tuition award (for Masters degree) ($11,000)
CSCI/CIHR (Canadian Institute of Health Research)
- Resident research award [Original Research] ($1000)
Chief Resident – Critical Care – University of Manitoba
First Prize – Jerry Scott Day – National research competition among Canadian
haematology fellows [Original Research] ($1000)
Second Prize - Internal Medicine, Resident Research Day [Original Research]
Second Prize - Internal Medicine, Resident Research Day [Case Presentation]
First Prize – Cancer Care Manitoba Research Day [Original Research]
Second Prize – Internal Medicine, Resident Research Day [Original Research]
CSCI/CIHR (Canadian Institute of Health Research)
- Resident research award [Original Research] ($1000)
First Prize – Cancer Care Manitoba Research Symposium [Original Research] ($1000)
Second Prize – Internal Medicine, Resident Research Day [Original Research]
Resident of the Month. (January) University of Manitoba
Aesculapian Award. University of Ottawa, Faculty of Medicine
Commonwealth Fund Bursary ($2000)
Second Prize - Summer Student Research Forum - University of Ottawa.
President, Aesculapian Society
Executive Vice President, Aesculapian Society
Curriculum Development - Faculty of Medicine - University of Ottawa
-Developed and implemented a novel stage II (clerkship) medical curriculum
to lessen the burden of early decision making with respect to residency
training.
Ryan Zarychanski
BOARD/COMMITTEE EXPERIENCES
2015-2018
2015
2014
2013- PRESENT
2013- 2015
2011-2014
2010-PRESENT
2010-2012
2010-2012
2005-2006
2003-2004
2003-2005
2001-2003
2000-2001
1997
1996-1998
1996
○ Discipline Appeals Committee, Faculty of Health Sciences, College of Medicine
○ Member, Department Head Search Committee, Department of Internal Medicine,
University of Manitoba (Winnipeg, Manitoba).
○ Member, Section Head Search Committee, Section of Haematology and Medical
Oncology, Department of Internal Medicine, University of Manitoba (Winnipeg,
Manitoba).
○ Leadership committee, Centre for Healthcare Innovation. University of
Manitoba/Winnipeg Regional Health Authority (Winnipeg, Manitoba)
○ Scientific Advisory Committee, Centre for Healthcare Innovation. University of
Manitoba/Winnipeg Regional Health Authority (Winnipeg, Manitoba)
○ Member, Lyonel G. Israels Memorial Lecture scientific committee
○ Chair, Academic Grand Rounds, Department of Hematology and Medical
Oncology, CancerCare Manitoba; Section of Hematology/Medical Oncology
University of Manitoba. (Winnipeg, Manitoba).
○ Overall Project Lead: Implementation of a Massive Transfusion Protocol in
The Winnipeg Regional Health Authority (Winnipeg, Manitoba)
○ B.Sc. (Medicine) Peer Review Panel (University of Manitoba)
○ Transfusion Practice Committee: Member. Health Sciences Centre (Winnipeg
Manitoba)
○ Career Planning Committee: Hematology residency: Member (Winnipeg, MB)
○ Hematology, Residency Training Committee: Member (Winnipeg, MB)
- Responsible for coordinating research activities for hematology trainees
○ Standards Committee (Critical Care, Winnipeg Regional Health Authority)
o CSCI/CHIR research award selection committee, Faculty of Medicine, U of M
○ Residency Training Committee (Haematology, University of Manitoba)
○ Canadian ICU Collaborative, Transfusion Practices working group
○ Accreditation Committee, Royal College of Physicians and Surgeons of Canada
○ Chair of the contract negotiations committee, PARIM (Professional
Association of Interns and Residents of Manitoba)
○ PARIM – Board and executive member – Winnipeg, Manitoba
○ CAIR board member (Canadian Association of Interns and Residents)
○ Internal Medical Resident Training Committee, University of Manitoba
○ Faculty Council Committee, University of Ottawa
○ Dean’s Advisory Board, Faculty of medicine, University of Ottawa
○ Admissions Committee, Faculty of medicine, University of Ottawa
○ Chair of the Peer Review Board, University of Ottawa
○ Dean’s Selection Committee – University of Ottawa
○ Board of Administration/Board of Directors for Student’s
○ Federation of the University of Ottawa (SFUO)
Ryan Zarychanski, BSc, BSc (Med), MD, MSc, FRCPC