TOXTCOLOGlC.\L DEPARTffEYT CRF 73

TOXTCOLOGlC.\L
CRF
DEPARTffEYT
73
AUTOPTIC
CARD
t
“I
SEX
1 II
F
STRAIN
Beagle
EXPERIMENT
026
,
i
j 200
TREATMENT
mg/kg
i.v.-
ORGAN
1.
2.
3.
4.
s.
BRAIN
g 77,1
HYPOPHYSIS
g 0,06
THYYUS
mg 9600
THYROlD
LUYGS
YOTE:
Autoptic:
splenanegaly
Histologic:
Date
-
27/g/76
6.
7.
8.
9.
10.
HEART
STOMACH
LIVER
SPLEEN
PANCREAS
g 84,3
g 277,4
g 8697
1 M
.
11.
12.
13.
INTESTINE
KIDNEYS
g 51,s
SUPRAR. G.mg 120
14.
15.
16.
GONADS
g 0,8
SEMINAL
VES.
PROSTATE OR
UTERUS
mg 210
TOXICOLOGICAL
CRF
Y
r -T
AUTOPTIC
2
1.
2.
3.
4.
5.
74
CARD
SEX
F
II
ORGAN
BRAIN
HYPOPHYSIS
THYYUS *
THYROID
LUYGS
YOTE:
Autoptic:
Histologic: Date
DEPART\lE\IT
27/g/76
STRAIN
Beagle
EXPERIMENT
026
I
,
i
TREATMENT
1200 mg/kg i.v.I
1 M
-
13 24’ Y *
g 69
g 0,049
mg 5500
6.
7.
8.
9.
10.
HEART,
STOMACH
LIVER
SPLEEN
PANCREAS
g
74,4
11.
12.
g 267,8
13.
g 2%
14.
15.
16.
INTESTINE
g 4197
KIDNEYS
SUPRAR. Gmg 700
GONADS
g 097
SEMINAL VES.
PROSTATE OR
UTERUS
mg moo
TOXICOLOGICAL
CRF
AUTOPTIC
DEPARTYEYT
CARD
1
SEX
F
Y
3 II
1.
2.
3.
4.
5.
ORGAN
BRAIN
g 7992
HYPOPHYSIS
g 0,063
THYWJS
mg 9300
THYROID
LU?IGS
YOTE:
Autoptic:
Histologic:
Date
STRAIN
Beagle
-
27/Q/76
EXPERIMENT
026
6.
7.
8.
9.
10.
HEART
STOMACH
LIVER
SPLEEN
PANCREAS
1
i
TREATMENT
I,200 mg/kg
i.v.-
1 U
65,s
11.
INTESTINE
g 243,7
g 4498
12.
13.
KIDNEYS
SUPRAR.
14.
15.
16.
GONADS
g O,7
SEMINAL
VES.
PROSTATE OR
UTERUS
mg 1400
g
g 3996
G.mg 1100
TOXICOLOGICAL
DEPARTVEYT
C
R
F
76
AUTOPTIC
CARD
I
SEX
SEX
Y
STRAIN
EXPERIMENT
1
TREATMENT
I
3'
.
.
AZ9
I2
1u
-
14
2.3
ORGAN
. BRAIN
g 69,4
. HYPOPHYSIS
g 0,074
. THYUUS
mg 14ooo
.
5.
THYROID
VOTE:
increase
Autoptic:
Date
HEART
STOMACH
LIVER
g 73
_
g 270.1
9.
SPLEEN
PANCREAS
g 6279
10.
LUYGS
Histologic:
6.
7.
8.
-
27/g/76
of pulmonal
pulmonal
histiccytic
volume
with
granulcme.
rough
11.
12.
13.
14.
15.
16.
section
INTESTINE
KIDNEYS
g 54,4
SUPRAR.
G.mg 10~0
GONADS
g 772
SEMINAL
VES.
PROSTATE
OR
UTERUS
mg 1300
on surface.
TOXICOLOGICAL
CRF
AUTOPTIC
r
DEPARTYEYT
77
CARD
I
I
I
I
EXPERIMENT
036
jl,
i
TREATMENT
mg/kg
i.v.-
1 M
!?
ii
i.
1.
2.
3.
4.
5.
ORGAN
BRAIN
g 69,2
HYPOPHYSIS
g 0,056
THYWJS
mg 13200
THYROID
LU"rlGS
6.
7.
8.
9.
10.
HEART
g 7994
STOMACH
LIVER
g 316,8
SPLEEN
g 21,7
PANCREAS
11.
*12.
13.
14.
15.
16.
ii
!\
I
YOTE:
Autoptic:
--
increase
Histologic:
Date
-
27/g/76
not
of pulmonal
specific
volume
chronic-reactive
with
rough
histiwytic
section
INTESTINE
KIDNEYS
SUPRAR.
GONADS
SEMINAL
-
g 44.9
G.mg 1300
g 6,2
VES.
PROSTATE
UTERUS
OR mg 2x0
surface.
gr~ul.ana
of
lung.
I.
AUTOPTIC
CARD
TREATMENT
1.
2.
3.
4.
5.
ORGAN
BRAIN
g 9497
HYPOPHYSIS
g 0,053
THYHUS
mg 12500
THYROID
LUYGS
YOTE:
Autoptic:
Histologic:
Date
-
27/g/76
NN
6.
7.
8.
9.
10.
HEART
g 88
STOMACH
LIVER
g 305,o
'SPLEEN
m 111,3
PANCREAS
11.
12.
13.
14.
15.
16.
.
INTESTINE
KIDNEYS
g 57,1
SUPRAR.
GFg 1000
GONADS
g 6,550
SEMINAL
VES.
PROSTATE OR
mg 2,O
UTERUS
TOXICOLOGICAL
CRF
Y
r1IV
DEPARTMENT
79
AUTOPTLC CARD
SEX
F
i
. 1
i
: :
.j
1.
2.
3.
4.
5.
I
ORGAN
STRAIN
Beagle
BRAIN
g 75,2
HYPOPHYSIS g 0,033
THYMUS mg 11300
THYROID
LUNGS
t
6.
7.
8.
9.
10.
I
EXPERIMENT
026
HEART
g
STOMACH
LIVER
g
SPLEEN g
PANCREAS
58
235,9
19,O
I
TREATMENT
100 mg/kg i.v.-
11.
12.
13.
14.
15.
16.
Date
27/9/76
NN
I
INTESTINE
KIDNEYS
g 46,5
SUPRAR. G.mg13OO
GONADS
g 600
SEMINAL VES.
PROSTATE OR
mg 1700
UTERUS
NOTE:
Autoptic:
Histologic:
1 M
. I
TOXICOLOGICAL
CRF
Y
r
AUTOF'TIC
I
SEX
c
YOTE:
Autoptic:
Date
-
27/g/76
EXPERIMENT
026
STRAIN
Beagle
ORGAN
BRAIN
g 73,3
HYPOPHYSIS
g 0,044
THYWJS
THYROID
LUYGS
Histologic:
80
CARD
2 IV
1.
2.
3.
4.
5.
DEPARTclEYT'
NN
6.
7.
8.
9.
10.
HEART
g 55,2
STOMACH
LIVER
g 187
SPLEEN
g 4596
PANCREAS
I
TREATMENT
I,loo mg/kg
i.v.-
11.
12.
13.
14.
15.
16 .
1 W
INTESTINE
KIDNEYS g 31~~
SUPRAR. G.mg 1100
GONADS go,=
SEMINAL VES.
PROSTATE
OR
--UTERUS- mg 2100
TOXICOLOGICAL
CRF
Y
r
AUTOPTTC
DEPARTMENT
81
CARD
I
SEX
F
3 IV
STRAIN
Beagle
EXPERIMENT
026
1
TREATMENT
i.v,i,100 mg/kg
1 M
1 /
1
/
3
- .
1.
2.
3.
4.
5.
ORGAN
BRAIN
g75,
2
HYPOPHYSIS
g 0906
mg 15O0O
THYYUS
THYROID
LUNGS
6.
7.
9.
8.
10.
HEART
STOMACH
LIVER
SPLEEN
PANCREAS
__ g 66,2
g 242,6
7097
11.
12.
14.
13.
INTESTINE
KIDNEYS
g 35p8
GONADS
SUPRAR.
Ggm; t ;l")
15.
16.
SEMINAL
VES.
PROSTATE OR
UTERUS
mg 2000
NOTE:
Autoptic:
I
Histologic:
Date
-
27/g/76
NN
ii
TOXICOLOGICAL
CRF
N
r
AUTOPTIC
SEX
M
I
STRAIN
Beagle
ORGAN
BRAIN
g 83,1
HYPOPHYSIS
0,07
THYWJS
mg 13800
THYROlD
LUNGS
NOTE:
Autoptic:
not
Histologic:
Date
82
CARD
IV
1.
2.
3.
4.
5.
DEPARTMENT
-
27/g/76
well
atrophy
EXPERIMENT
026
6.
7.
8.
9.
10.
developed
of
testicles,
HEART
STOMACH
LIVER
SPLEEN
PANCREAS
testicles
1
TREATMENT Physiol*
~l-riT@S&
i.v.1 M
g 6339
g 251,6
g 4594
for
hypophisis
the
11.
12.
13.
14.
15.
16.
age of dog.
hyalin
cyst.
INTESTINE
KIDNEYS
g 39,4
SUPRAR.
G.mg 1100
GONADS
g 292
SEMINAL
VES.
PROSTATE OR mg 900
UTERUS
TOXICOLOGICAL
DEPARTMEUT
CRF
83
AUTOPTIC
CARD
Y
SEX
2V
M
STRAIN
Reagle
/
EX;f':IMENT
/sol~T;;v~f'~.
1
I
j
!
j
[
j
I
i
i
1.
2.
3.
4.
5.
ORGAN
BRAIN
g 67
HYPOPHYSIS
go,06
THYYUS mg 9900
THYROID
LUYGS
HEART
g 7694
STOMACH
LIVER
g 21%2
SPLEEN g 86,l
PANCREAS
:
YOTE:
Autoptic:
Histologic:
Date
6.
7.
8.
9.
10.
-
27/9/76
NN
11.
12.
13.
14.
15.
16.
INTESTINE
KIDNEYS
g 48,l
SUPRAR.
Gmg 1203
GONADS
g 599
'SEMINAL
VES.
PROSTATE
O R mg 1700
UTERUS
TOXICOLOGICAL
C
AUTOPTIC
DEPART\iEYT
R
F
CARD
EXPERIMENT
026
STRAIN
Beagle
TREATMENT
&i.v.-
bol,
eysiol.
1 M
I
1
I
I
ORGAN
1.
BRAIN
g 69,1
2.
3.
HYPOPHYSISg
0,112
THYMUS
mg 8200
4.
5.
THYROID
LWYGS
VOTE:
Autoptic:
Histologic:
Date
27/9/76
NN
6.
HEART
g 78,3
7.
8.
STOMACH
_
LIVER
g 286,l
9.
10.
SPLEEN
PANCREA -3 89,2
11.
12.
13.
14.
15.
16.
INTESTINE
KIDNEYS
;;pN:;-
g 5333
Gingl400
SEMINAL
VE E4
PROSTATE OR mg 1300
UTERUS
:
i
i
TOXICOLOGrCAL
CRF
AUTOPTIC
DEPARTMEYT
85
CARD
dol.
1 M
?
I
I
1.
2.
3.
4.
5.
ORGAN
BRAIN
g 78~5
HYPOPHYSIS
g 0,056
g 11cOO
THYWS
THYROlD
LUYGS
6.
7.
8.
9.
10.
HEART
g 7796
STOMACH
LIVER
g 202,5
SPLEEN
g 4097
PANCREAS
11.
12.
13.
14.
15.
16.
INTESTINE
KIDNEYS
g 39,5
SUPRAR.
Gmg 1100
GONADS
g 096
SEMINAL
VES.
PROSTATE OR
UTERUS mg 2ooO
YOTE:
Autoptic:
Histologic: *-
Date
27/g/76
~JN
t
TOXICOLOGICAL
CRF
AUTOPTIC
I
SEX
F
I
STRAIN
Beagle
ORGAN
g 82,3
BRAIN
HYPOPHYSIS
g o,064
THYWJS
mg 8800
THYROlD
LUYGS
NOTE:
Autoptic:
Histologic:NN -
Date
86
CARD
Y2 VI
1.
2.
3.
4.
5.
DEPARTYEYT
27/g/76
I
6.
7.
8.
9.
10.
EXPERIMENT
026
g 6575
HEART
STOMACH
LIVER
g 227
SPLEEN
g 28f1
PANCREAS
11.
12.
13.
14.
15.
16.
INTESTINE
KIDNEYS
g 36,8
SUPRAR.
GQ'E 1@30
GONADS
g 096
SEMINAL
VES.
PROSTATE OR
UTERUS
mg 1600
TOXICOl,OGIC,JL
CRF
AUTOPTIC
87
CARD
13
ORGAN
7797
1. BRAIY
g
2. HYPOPHYSIS g 0,055
3. THYYUS mg 7800
4. THYROID
5. LUYGS
YOTE:
Autoptic:
Histologic: Date
DEPt!RTYEUT
27/9/76
NN
14
6. HEART
g 6471
7. STOMACH
8. LIVER
g 195,4
9. SPLEEN
g 61,5
10. PANCREAS
Y
*
11.
3.2.
13.
14.
15.
16,
(
INTESTINE
KIDNEYS
g 40,4
SUPRAR. G.mg 1200
GONADS
g 0,500
SEMINAL VES.
PROSTATE OR
UTERUS mg 1700
* i
r( 1
[I
, j
i J
88
C.R.‘.
7I
Toxicological
Department
Clinical
.
II
’
TREATMENT
EXPERIVENT
Oi !6
STRAIN
N.
,
Date
7.5.76
i2.5.76
'7.5.76
--I--
1.6.76
6.6.76
11.6.76
M
1 MONTH
iv
Observation
)ietg
380
289
438
318
254
294
344
283
ei ht
6900
6900
7100
2w
card
SEX
r its
: vocalization
P{AS:
- sedation-agitation
tremorLataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
myosis-mydriasis-salivation-lacri
mation.
bradypnea-dyspnea
I?espiratory:
bradycardia-arrhythmia
tones.
(:ardiovascular:
.
,Gastrointestinal:
diarrhoeation-flatulencetractionsstool.
vulva
mammary
penis-proptosis.
Genitourinary:
boss
constipacoE
coloured
glands
/
Skin
I
hair:
t
Mucosa:
Eyes:
P.S.
eruptionsblushinglosseslividity-
hair
erection
flaccidity.
cpngestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN
= no
signs
-_
-L
-
*:
Date
of death:
Weiqht
at death:
Exitus:SODIUM
m&
Date:
27.9.76
22.6.76
6 goo
-
C’. R . i’ .
Toxicological
f
1
i 1
89
Department
Clinical
.
21
.I N.
I--- EXPERIMEVT
02
1.-iv
STRAIN
ND
Date
17.5.76
Z2.5.76
Z7.5.76
1.6.76
6.6.76
11.6.76
iqhtg
9503
0100
34Qo
loo0
1400
1200
1200
1200
1300
16.5.76
L6.6.76
Z1.6.76
1
TREATMENT
-
I
)iet
1 MONTH
Observation
v;
400
449
472
488
500
500
500
500
500
card
SEX
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
JCS : vocalization
~
qAS: myosis-mydriasis-salivation-lacr&
mation.
bradypnea-dyspnea
Respiratory:
Zardiovascular:
bradycardia-arrhythmia
tones.
.
Gastrointestinal:
diarrhoeaconstipation-flatulencecon
tractionscoloured
stool.
i
Genitourinary:
:
boss
’
penis
:
i
I
1
i
i
J
Skin
hair:
,
Mucosa:
: i
9
lossesl(vidity-
i 1’
-
L
‘
i
Eyes:
P.S.
I
Date
Wei qht
Exitus:
Date:
of
death:
at death:
--5x
. .
11,100
SGDIUMPENTOTHAL
27.9.76
eruptionsblushing-
vulva
mammary
proptosis.
hair
erection
fY.accidity.
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN
glands
= no signs
*
M
c .F?.;.
rj
: ’
1i !
1-i
f
i I
Toxicological
90
Department
Clinical
EXPEI
0;
STRAIN
N. ZEE
Date
17.5.76
22.5.76
27.5.76
----I-3..6.76
6.6.76
11.6.76
16.6.76
21.6.76
Wei ht
8200
8700
8700
9100
9500
95CX-l
9303
9500
Dietq
420
450
500
483
500
500
427
419
I2wiv
-
1
?
;
‘
:
1 MONTH
Observation
KS:
vocalization
- sedation-agitation
tremordataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
NAS:
myosis-mydriasis-salivation-lacrimation.
bradypnea-dyspnea
Respiratory:
I
card
Cardiovascular:
bradycardia-arrhythmia
tones.
Gastrointestinal:
diarrhoeation-flatulencetractionsstool.
.
Genitourinary:
boss
vulva
mammary
constipaco:
coloured
glands
penis-proptosis.
Skin
Mucosa:
Eyes:
P.S.
22.6.:
of death:
Date
9,100
Weight
at death:
SODIUM
PSNTOll-IAL
Exitus:
27.9.76
Date:
hair:
eruptionsblushinglossesli-vidit'y-
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
W-4 = no
signs
I
-_
C.R.r.
_.
91
i !
Toxicological
Department
Flinical
.
1 TT
STRAIN
N.
,
1.6.76
6.6.76
11.6.76
16.6.76
21.6.76
Nn
8700
EXPERIMENT
02
Dietq
400
421
490
500
498
454
454
398
1 TREATMENT
lac00
j"
F
1 MONTH
Observation
YCS : vocalization
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
NAS:
myosis-mydriasis-salivation-lacr&
mation.
Respiratory:
bradypnea-dyspnea
bradycardia-arrhythmia
tones.
Cardiovascular:
1 : diarrhoeation-flatulencetractionsstool.
Gastrointestina
Genitourinary:
boss
penis
Skin
hair:
Mucosa:
Eyes:
P.S.
Date
of death:
22.6.76
Weight
at death:
g,m
Exitus:
SoDIuMPENToTwL
Date:
27.6.76
-
card
SEX
eruptionsblushinglosseslividity-
constipacon
coloured
vulva
mammary
proptosis.
glands
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN
= no
signs
i
C-R.?.
92
Toxicological
STRAIY
N. ZFDate
17.5.76
22.5.76
27.5.76
-t1.6.76
6.6.76
11.6.76
16.6.76
21.6.76
Wei ht
7800
7800
7700
8300
8400
8300
7eOo
8003
Department
EXPERIqENT
i
TREATMENT
02 !6
1 MONTH
I2mm
~iv
-?Dietq
Observation
350
KS: vocalization
287
- sedation-agitation
tremor-ataxia-catatony-convulsion
429
paralysis-irritability-anesthesia
310
rigidity-flaccidity.
351
360
VAS: myosis-mydriasis-salivation-lacri
376
mat ion.
419
Respiratory:
bradypnea-dyspnea
Cardiovascular:
bradycardia-arrhythmia
tones.
.
Gastrointestinal:
diarrhoeaconstipation-flatulenceco2
tractionscoloured
stool.
Genitourinary:
boss
penis
Skin
hair:
Mucosa:
eruptionsblushinglosseslividi&y-
vulva
mammary
proptosis.
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
Eyes : ptosis-exophthalmus-nystagmus
opacity.
P.S.
m
'6
Da e of death:
Weiqht
at death:
8~@30
SODIUM PENTOTHAL
Exitus:
27.9.76
Date:
NN
= no
glands
signs
. .
c . R . ;‘ .
Toxicological
93
Department
.-
STRAIN
N.
,E E
Date
1 7.5.76
2 2.5.76
2'7.5.76
--I-1.6.76
/ 6.6.76
1.6.76
6.6.76
:1.6.76
!
j
i
I
02
D
ei ht
6800
6900
6800
‘4 0 0
‘3 0 0
“ml
‘l o o
'3 0 0
3
.
Dietv
403
419
419
394
472
374
380
416
;
rlcs : vocali2ation
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
'IA S :
myosis-mydriasis-salivation-lacr_i_
mat ion.
Respiratory:
bradypnea-dyspnea
j
Cardiovascular:
1
/
Observation
I
bradycardia-arrhythmia
tones.
.
Gastrointestinal:
/
diarrhoeation-flatulencetractionsstool.
,
G e n itourinary:
boss
penis
Skin
hair:
eruptionsblushing-
vulva
mammary
proptosis.
constipaco2
coloured
glands
hair
erection
flaccidity.
.
*
Mucosa:
Eyes:
P .S .
” ?
!3.6.76
D a t e of death:
7,100
Weiqht
at death:
S O D IUM P E N 'K K H A L
Exitus:
27.9.76
Date:
lossesl<vfdity-
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NY = no
signs
_ -.I
I
C.P..?.
94
Toxicological
.I
I
STRAIN
N..._ZEELAND
Date
7.5.76
2.5.76
--I-7.5.76
1.6.76
6.6.76
1.6.76
6.6.76
1.6.76
TREATMENT
EXPERIVENT
02 !6
ht
Dietq
7900
8500
8500
8800
I 8,Qoo
9 100
9 ~100
91200
380
363
419
380
384
404
371
359
Wei
Department
1 MONTH
IV
Observation
N cs:
- sedation-agitation
vocalization
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
N AS:
myosis-mydriasis-salivation-lacrl
mation.
bradypnea-dyspnea
ALespiratory:
C:ardiovascular:
bradycardia-arrhythmia
tones.
l
Ciaktrointestinal:
.
diarrhoeation-flatulencetractionsstool.
I
(;enitourinary:
boss
constipaco=
coloured
vulva
glands
mammary
penis-proptosis.
skin
Mucosa:
.
Eyes:
eruptionsblushing-
hair:
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
lossesliwidity-
ptosis-exophthalmus-nystagmus
opacity.
P.S.
>
, ~
,
I
23.6.76
of death:
Date
Weight
at death:
8,900
Exitus:
Date:
SODIUM PFNTCYI'HAL
27.9.76
NN = no
signs
..-
_
c.F?.i’.
95
Toxicological
Department
Clinical
'2
EXPERIMENT
STRAIN
N. zEj&&il
Date
.7.5.76
!2.5.76
!7.5.76
-I---1.6.76
6.6.76
.1.6.76
.6.6.76
!1.6.76
III
card
SEX
TREATMENT
1 MONTH
Wei ht
8300
8600
8700
9Qoo
3100
3300
3200
3400
)ietg
370
327
226
372
386
242
237
252
Observation
- sedation-agitation
FKS : vocalization
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
FJAS:
myosis-mydriasis-salivation-lacri
mation.
bradypnea-dyspnea
I Iespiratory:
(Zardiovascular:
bradycardia-arrhythmia
tones.
(Gastrointestinal:
diarrhoeation-flatulencetractionsstool.
.
vulva
mammary
penis‘proptosis.
,Genitourinary:
Skin
hair:
Mucosa:
Eyes:
P.S.
23.6.76
Date
of death:
Weight
at death:
9,400
Exitus:
S0DH.M PENTCYTHAL.
27.9.P6
Date:
boss
eruptionsblushinglosseslcvidity-
= no
co"
coloured
glands
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN
constipa-
signs
M
96
Toxicological.
-i-
STRAIN
N.ZEELAND
Date
-7.5.76
22.5.76
27.5.76
---I-1.6.76
6.6.76
.1.6.76
.6.6.76
'1.6.76
Wei
ht
9300
97w
9903
10600
10800
llooo
11100
11200
Department
EXPER
02
Diets
390
352
426
453
442
470
412
433
1 MONTH
Observation
NCS:
- sedation-agitation
vocalization
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
NAS:
myosis-mydriasis-salivation-lacri
mation.
-
bradypnea-dyspnea
Respiratory:
Cardiovascular:
bradycardia-arrhythmia
tones.
Gastrointestinal:
diarrhoeation-flatulencetractionsstool.
.
Genitourinary:
boss
constipaco:
coloured
vulva
mammary
glands
penis-proptosis.
Skin
hair:
Mucosa:
Eyes
P.S.
-
24.6.
Date
of death:
10,800
Weiqht
at death:
SODIUM PENTOTHAL
Exitus:
27.9.76
Date:
:
eruptionsblushinglossesIi-vidity-
hair
erection
flaccidity.
congeStion-hemorrhage.
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN
= no
signs
c.!?.i‘,
97
i: ’
J
I
.!
STRAIN
N. 7EET
Date
1 7.5.76
2 2.5.76
2 -t7.5.76
1.6.76
6.6.76
1.6.76
6.6.76
1.6.76
;i
ii
Toxicological
Wei
-iht
EXPERIMEVT
1 TREATMENT
0;
LULmdKu
Dietg
320
258
396
310
367
414
263
339
6700
6700
6800
7400
I 7!?00
‘800
‘500
'600
Department
;
-
1 MONTH
Observation
iIcs : vocalization
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
JAS:
myosis-mydriasis-salivation-lacr2
mation.
I
qespiratory:
i
‘
iv
bradypnea-dyspnea
Zardiovascular:
bradycardia-arrhythmia
tones.
Gastrointestinal:
diarrhoeation-flatulencetractionsstool.
.
i
I
’ :
Genitourinary:
i I
!
boss
penis
Skin
hair:
Mucosa:
i i
Eyes:
P.S.
Date
of death:
24.6.76
Weiqht
at death:
6,800
Exitus:
SODIUM PENTOTHAL
27.9.76
Date:
eruptionsblushinglosses1~vidity-
vulva
mammary
proptosis.
= no
calf
coloured
glands
hair
erection
flaccidity.
congestion-hemorrhage.
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN
constipa-
signs
c. P. . ;‘.
98
Toxicological
N.
-1
EXPERIMENT
sTRAIni
: ?i
1
:!
i/ 1i
Department
Date
ightu
)iet
7.5.76
2.5.76
7.5.76
1.6.76
5.6.76
1.6.76
6.6.76
1.6.76
600
200
800
200
so0
200
300
200
50
12
56
79
61
66
21
,38
/
t TREATMENT
(l$me/Ka
iv
02
ND
g
-
1 MONTH
Observation
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
ICS : vocalization
tAS:
myosis-mydriasis-salivation-lacri
mation.
bradypnea-dyspnea
lespiratory:
Zardiovascular:
bradycardia-arrhythmia
tones.
;astrointestinal:
diarrhoeation-flatulencetractionsstool.
l
’
Cenitourinary:
.
i
Skin
hair:
: i
Mucosa:
Eyes:
P.S.
I
;
boss
vulva
mammaqry
penis
proptosis.
eruptionsblushing-
glands
hair
erection
flaccidity.
ptosis-exophthalmus-nystagmus
opacity.
= no
cof!
coloured
congestion-hemorrhage.
icterus.
lossesli*vidity-
NN
constipa-
d*
signs
Date
of death:
24.6.76
Weight
at death:
5,600
Exitus:
SODIUM PENTOTHAL
Date:
27.9.76
.
.
99
Toxicological
Department
Clinical
- **EXPERIMEYT
I 02 T6
STRAIN
N.
7i J
H
ii
Date
'-5.76
1.5.76
l.5.76
-I--.6.?6
i.6.76
..6.76
1.6.76
..6.76
Wei
Dieto
ht
7500
7800
7600
7903
7800
7800
79cO
7900
360
320
383
302
345
390
388
372
card
SEX
'3Iv
TREATMENT
IGQ inU/t(U
iv
F
1 MONTH
Observation
N:cs : vocalization
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
hIAS:
myosis-mydriasis-salivation-1acrL
mation.
Flespiratory:
bradypnea-dyspnea
( Zardiovascular:
bradycardia-arrhythmia
tones.
(Zastrointestinal:
diarrhoeation-flatulencetractionsstool.
.
/Genitourinary:
boss
vulva
mammary
constipacop
coloured
glands
penisproptosis.
Skin
Mucosa:
Eyes:
P.S.
-L
!4.6.7t
Date
of death:
7,200
Weight
at death:
SODIUM PENTOTHAL
Exitus:
Date:
27.9.76
hair:
eruptionsblushinglossesli-vidity-
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NY = no
signs
_
c.t?.;‘.
Toxicological
Department
Clinical
.
IV
I-I
STRAIN
V. ZEFUND
3ate
7.5.76
2.5.76
7.5.76
---I--
L .6.76
5.6.76
L .6.‘76
5.6.76
1.6.76
Wei
EXPERIMEVT
lietq
ht
8200
8400
8300
i7OQ
3600
3700
u3oo
3800
1
02 16
360
320
357
286
305
385
282
354
TREATMENT
1 Pb&&Ol.S_0liv
-
card
SEX
1 MONTH
Observation
CS:
- sedation-agitation
vocalization
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
AS:
myosis-mydriasis-salivation-lacrimat ion.
bradypnea-dyspnea
lespiratory:
:ardiovascular:
bradycardia-arrhythmia
tones.
iastrointestinal:
diarrhoeation-flatulencetractionsstool.
l
senitourinary:
Skin
hair:
Mucosa:
Eyes:
boss
vulva
i mammary
penis
proptosis.
eruptionsblushinglosseslividity-
Date
of death:
24.6.76
Weight
at death:
8,300
Exitus:
soD1uMPENT0THALJ
Date:
27.9.76
glands
hair
erection
flaccidity.
ptosis-exophthalmus-nystagmus
NY = no
coy
coloured
congestion-hemorrhage
icterus.
opacity.
P.S.
constipa-
signs
.
M
c .R.i .
101
ToxicologIcal
Department
Clinical
.
2v
EXPERIMENT
02
STRAIY
N.7&&&ND
Date
17.5.72
Z2.5.76
27.5.76
----I-1.6.76
6.6.76
11.6.76
si I
1I
i i
16.6.76
21.6.76
Wei ht
'7200
7600
7500
7800
8100
I
8200
8200
8200
Dietg
330
303
376
335
368
336
387
316
i TREATMENT
lphysiol.so3
iv
M
1 MONTH
Observation
ICS:
vocalization
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
IAS:
myosis-mydriasis-salivation-lacri
mat ion.
lespiratory:
? ’
-
card
SEX
bradypnea-dyspnea
i !
:ardiovascular:
bradycardia-arrhythmia
tones.
;astrointestinal:
diarrhoeation-flatulencetractionsstool.
.
constipaco2
coloured
I
.
.* :
Skin
hair:
::
;i
Mucosa:
Eyes:
P.S.
i
vulva
mammary
penis-proptosis.
Genitourinary:
i
'5.6.76
Date
of death:
7,800
at death:
Weight
SODIUM PENTOTHAL
Exitus
27.9.76
Date:
boss
eruptionsblushinglosseslievidity-
glands
hair
erection
flaccidity.
-congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN = no
signs
/
c‘.F!.;.
102
.I
Toxic0
EXPERIYEVT
TRE T4ZEYT
RlyslO 4 .sol*
02 '6
-I
Observation
3iete
400
369
430
404
337
256
357
421
1
2
2
f--i
: I
i!
Department
Clinical
.
3
STRAIN
N. Z-ND
1.6.76
6.6.76
.1.6.76
.6.6.76
!1.6.76
ogical
~
?j
:
. ;
_
v
card
SEX
1 MONTH
:JCS : vocalization
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
fJAS:
myosis-mydriasis-salivation-lacri
mation.
I?espiratory:
bradypnea-dyspnea
(Cardiovascular:
bradycardia-arrhythmia
tones.
Gastrointestinal:
diarrhoeation-flatulencetractionsstool.
.
vulva
mammary
penis‘proptosis.
Genitourinary:
Skin
Mucosa:
Eyes:
P.S.
hair:
boss
eruptionsblushinglossesl:vidity-
constipacon
coloured-
glands
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
NN = no
signs
-_
Date
of death:
25.6.76
Weieht
at death:
9,600
Exitus:
SODIUM PENTOTIUL
Date:
27.9.76
.
!
i
M
‘I
i
C.R.?.
.1
Toxicological
103
Department
Clinical
'1
1.6.76
6.6.76
1.6.76
6.6.76
11.6.76
TREATMENT
[email protected]
EXPERIWEVT
16
STRAIN
N.ZEELAlvn
Iietg
150
192
173
i69
!80
$68
337
'48
8800
I t 3800
3700
3800
3800
_
VI
card
SEX
1 MONTH
Observation
- sedation-agitation
bICS : vocalization
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
r(AS:
myosis-mydriasis-salivation-1acrL
mation.
bradypnea-dyspnea
Iiespiratory:
(Zardiovascular:
bradycardia-arrhythmia
tones.
Gastrointestinal:
diarrhoeation-flatulencetractionsstool.
.
Genitourinary:
boss
penis
.
:
)
a
!
Skin
Mucosa:
Eyes:
P.S.
/
i
/
-Jof death:
Date
25.6.76
Weiqht
at death:
8,500
Exitus:
SODIUM PENTDate:
27.9.76
hair:
eruptionsblushinglossesl<vidity-
mammary
proptosis.
co1
coloured
glands
hair
erection
flaccidity.
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
Nhl = no
constipa-
signs
, *
F
c.l? .i.
104
Toxicologica
7
STRAIN
N.
WD
1 Depa-
EXPERIMEYT
7800
7700
8100
7800
1
0;
Diets
1.6.76
6.6.76
11.6.76
16.6.76
21.6.76
tment
350
250
400
292
303
400
432
372
TREATMEFVT
&y~l.sol.
-
iv
1 MONTH
Observation
NCS : vocalization
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
NAS: myosis-mydriasis-salivation-lacri
mation.
Respiratory:
bradypnea-dyspnea
Cardiovascular:
bradycardia-arrhythmia
tones.
.
Gastrointestinal:
diarrhoeaconstipation-flatulencecop
tracticnscoloured
stool.
Genitourinary:
boss
penis
Skin
hair:
Mucosa:
Eyes:
P.S.
Date
Weiqht
Exitus:
Date:
of
25.6.76
death:
at death:
8,0@0
SODILiMPENTO?HAL
27.9.76
eruptionsblushinglosseslcvidity-
i
vulva
mammary glands
proptosishair
erection
flaccidity.
congestion-hemorrhage
icterus.
ptos$s-exophthalmus-nystagmus
opacity.
NN = no signs
c‘.i?
.;.
105
Tox i colo.gica
-?
I
I
1 Department
3
i
Clinical
STRAIN
N. ZE]
Date
7.5.76
2.5.76
7.5.76
1.6.76
6.6.76
1.6.76
6.6.76
1.6.76
card
0;
AXD
reiehtq
7300
7500
7400
7000
7300
liet
q
390
361
445
422
456
436
425
387
72cxl
7100
'2 0 0
Observation
‘C S :
vocalization
- sedation-agitation
tremor-ataxia-catatony-convulsion
paralysis-irritability-anesthesia
rigidity-flaccidity.
IA S :
myosis-mydriasis-salivation-1acrL
mation.
lespiratory:,
bradypnea-dyspnea
bradycardia-arrhythmia
tones.
:ardiovascular:
.
3astrointestinal:
diarrhoeation-flatulencetractionsstool.
Skin
,
hair:
Mucosa:
Eyes:
P .S .
Date
of death:
25.6.76
Weight
at death:
6,700
Exitus:
S O D ILbl P E N T O T H A L
Date:
27.9.76
I
vulva
mammary
penis-proptosis-
Genitourinary:
boss
constipacop
coloured
glands
eruptions-'hair
erection.
blushingflaccidity.
losseslividity-
congestion-hemorrhage
icterus.
ptosis-exophthalmus-nystagmus
opacity.
W
= no
signs
I
:
CRF
TOXICOLOGICAL
.-Ar lalytic
bI.
- 1 T
card
SEX
STRAIN
Beagle
M
106
DEPARTMENT
EXPERIMENT
026
TREATMENT
mg/Kg i.v.-
1 month
BIOCHEMISTRY
HEMATOLOGY
E3LOOD
~
C:0
URINE
meq/l
2
Tot.
22
prot.
mg %
Cholestei-.
mg %
mg %
bilirub.mg%
91k.
ohos.
LDH mu/ml
SGPT mu/ml
x 10
L
Ib g % ml
-
:rythr.
0.3
La
0,l
Sediment
NN
deukocytic
iorinula
rJeutoph.
P.S.
1 ,03i
Lynph.
500
u(onocytes
0
30
Eosinoph.
4
Basoph.
.dL
Reticu1.x
Ya+ meq/l
123
Plat.
Ca
++
me: %
-A&.?-
66
JXS
meq/l
6
57,9
meq/l
K+
7.2
QA
x 10
Urobilinogen
SGOT mu/ml
cl-
3
Blood
l
mU/ml
%
Bilirubin
3UN mg %
rot.
ttc
,eukock
g %
phos.
(;lucose
6
g %
Albumine
In.
pH
1
4,7
T.
lo3
u,v
705
x mm3
proth.
13
see
12
18
I
Date
27/Q/76
J
CRF
TOXICOLOGICAL
alytic
.
21
card
SEX
M
107
DEPARTMENT
STRAIN
eagle
EXPERIMENT
026
TREATMENT
m.g/Kg i.v.-
1 month
I
BIOCHEMISTRY
HEMATOLOGY
LOOD
.
prot.
llbumine
:n.
‘
I
1
meq/l
'O2
'ot
URINE
20
I
1~"
47
g %
Leukoc;
-=-I
g %
phos.
IO3
7?
13,i?
Hb g % ml
mg %
:holester.
x
mg 46
lirubin
rythr.
x
10
6
6,8
69.1
ICV
.ood
*obilinoge
?diment
lk.
phos.
DH mU/ml
mU/ml
‘eukocytic
~orznula
leutoph.
38
.ynph.
M
;GOT mu/ml
60
Basoph.
:I-
meq/l
133
Reticu1.x
Ja+ meq/l
125
Plat.
meq/l
Gi++
mg %
Date
27/g/76
2
Zosinoph.
,GPT mU/ml
<+
0
6onocytes
t
T.
lo3
x mm3
108
CRF
TOXICOLOGICAL
nalytic
N.
3
card
SEX
I
DEPARTMENT
EXPERIMENT
026
STRAIN
Ei.eacle
M
TREATMENT
200 mq/Kg i.v.-
1 month
BIOCHEMISTRY
HEMATOLOGY
BLOOD
co2
I
f
URINE
meq/l
'ot.
prot.
Llbumine
:n.
g %
g %
phos.
rythr.
mg %
:holester.
mg %
x
Bilirubin
ICV
Urobilinoger
.eukocytic
pormula
Jeutoph.
10
6
-ynph.
LDH mu/ml
tionocytes
SGPT
Eosinoph.
mu/ml
Basoph.
SGOT mu/ml
Reticu1.x
Plat.
lo3
315
x mm3
t-
T.
Cat+
Date
proth.
sec.
r-
13,3
m.g %
27/9/76
I:
/
i
I
CRF
TOXICOLOGICAL
alytic
109
DEPARTMENT
card
TREATMENT
EXPERIMENT
BIOCHEMISTRY
HEMATOLOGY
.lbumine
n.
g %
phos.
mg %
:holestGr.
Tot
1
ilk.
ohos.
mU/ml
x
10
"b-
ICV
}
bilirub.mg%
I--
:rythr.
mg %
IUN mg %
10,6
bg%ml
14,2
091
IUrobiEnogenk
I
NN
.i .eukocytic
:ormula
leutoph.
r
, I 4ynph.
O
fionocytes
,DH mu/ml
I;GPT
Eosinoph.
mu/ml
SGOT mU/ml
Basoph.
Zl-
meq/l
Reticu1.x
Ya*
meq/l
Plat.
K+
meq/l
T.
096
lo3
I-
535
x mm3
proth.
sec.
tt-
ca++
w
Date
27/g/76
%
..-:
-1,
110
CRF
TOXICOLOGICAL
nlytic
'2
card
SEX
II
F
STRAIN
eavle
DEPARTMENT
EXPERIMENT
026
TREATMENT
00 mg/Kg
i.v.I
1 month
I
BIOCHEMISTRY
HEMATOLOGY
El ;OOD
ii
!1
.3
I
!
I
I
I
Cl D2 meq/l
Tt ot.
tc
prot.
g %
A lbumine
%
,eukoc:
g %
x
10
+-i--
3
lb g % ml
i
I n.
I
URINE
1
i
phos.
mg
C holester.
%
:rythr.
mg %
G lucose
Bilirubin
mg % *
bilirub.mgf
A lk.
ohos.
lo6
ICV
-L
B UN mg %
T ot.
x
Urobilinogen
I&-
0.1
NN
.eukocytic
:ormula
Jeutoph.
30
I--
mU/mI
tionocytes
L ,DH mu/ml
:i
c iGPT mU/ml
Basoph.
EiGOT mu/ml
/i
C:l-
meq/l
P?a+ meq/l
I<+
meq/l
Ca++
m.g %
Date
27/g/76
r
T.
proth.
sec.
CRF
TOXICOLOGICAL
lalytic
1.
3 II
card
SEX
STRAIN
Beagle
F
111
DEPARTMENT
EXPERIMENT
026
TREATMENT
200 m,g/K.g i.v.-
1 month
BIOCHEMISTRY
HEMATOLOGY
$LOOD
URINE
ilbumine
F
g %
.eukoch
x
3
Ib g % ml
Srythr.
Zholester.
10
Bilirubin
mg %
3UN mg %
q -
Q.1
NN
x
10
6
lICV
ieukocytic
?ormula
Yeutoph.
72
L
Alk.
phos.
mu/ml
1.02:
Lynph.
26
LDH mu/ml
Honocytes
SGPT
mU/ml
Eosinoph.
SGOT
mu/ml
2
'0
Basoph.
'
Reticu1.x
Plat.
T.
ca++
14 3
me; %
i
Date
27/g/76
0
lo3
0.4
295
x mm3
proth.
sec.
.
8.5
CRF
112
TOXICOLOGlZCAL DEPARTMENT
.-Ar lalytic
bI.
1 III
-
card.
SEX
M
STRAIN
Beaule
EXPERIMENT
026
TREATMENT
lODm,g/Kg i.v.-
1 month
BIOCHEMISTRY
HEMATOLOGY
ILOOD
URINE
IO2 meq/l
prot,
rot.
6
g %
ilbumine
Cn. phos.
mg %
Zholester.
41k.
phos.
LDH mU/ml
ib g % ml
-
srythr.
x lo6
0,l
m
1,016
mU/ml
270
Leukocytic
Formula
Neutoph.
18
Lynph.
50
Eosinoph.
SGOT mu/ml
Basoph.
Plat.
Na+ meq/l
Ca
T.
meq/l
K+
++
Date
m.g %
27/9/76
14,5
12
0
Reticu1.x
meq/l
g 0
Monocytes
SGPT mu/ml
cl-
3
acv
Urobilinogen
bilirub.mg4
x 10
l
3UN mg %
rot.
%
A
Bilirubin
mg %
mg %
Itc
,eukoc;
g %
;lucose
--A
-
lo3
x mm3
proth.
set
ci,5
450
8.5
_
CRF
TOXICOLOGICAL
113
DEPARTMENT
BIOCHEMISTRY
HEMATOLOGY
BLOOD
URINE
20
meq/l
co2
Tot.
prot.
g %
Albumine
g %
phos.
In.
mg %
Cholestek.
,lucose
mg %
mg % '
bilirub.mg'
ilk.
phos.
mu/ml
30
Htc
47
%
7,7
Prot.
4.2
Glucose
L
Hb g % ml
9
.Ketones
-
':rythr.
165
.Bilirubin
;25
Blood
mg $1
Urobilinoger
#UN mg %
'ot.
6
pH
Leukocs
x
x
6
IO3
10
6
rfq
69,l
dCV
0,l
Leukocytic
Formula
NN
Neutoph
1.05:
Lynph.
AR
.
40
.DH mu/ml
Monocytes
0
;GPT
mu/ml
Eosinoph.
12
iGOT
mu/ml
Basoph.
:1-
meq/l
Reticu1.x
rla+
meq/l
Plat.
<+
meq/l
T.
Ca
++
Date
mg; %
27/9/76
A
-0
0,2
i03
x mm3
proth.
set
335
8.5
CRF
TOXICOLOGICAL
I
Ar
,- lalytic
Ir J.
3 III
card
ISEX
I
M
[STRAIN
IBeaole
1 EXPERIMENT
1
026
f
TREATMENT
mg/Kg i.v.-
1 month
BIOCHEMISTRY
HEMATOLOGY
3LOOD
URINE
iyziy
20
prot.
rot.
g %
jlbumine
Ln.
g %
phos.
Zlucose
mg %
mg %
l
3UN mg %
fuvrot.
bilirub.mg$
41k.
phos.
mu/ml
n
75
SGOT mu/ml
70
K.+
71,4
E
7
,Sediment
P.S.
_
NN
Leukocytic
FormulaNeutoph.
1.039
Lynph.
0.1
0
Eosinoph.
2
Basoph.
0.
meq/l
Plat.
meq/l
T.
Date
27/g/76
%
48
Monocytes
Reticu1.x
w
7
x lo6
MCV
meq/l
ca++
15.4
Blood
:155
SGPT mu/ml
Erythr.
.Bilirubin
115
80
x lo3
Hb g % ml
a,1 .Ketones
155
I--50
3tc%
Leukoc;
Glucose
285
LDH mU/ml
+
mg X1
__3~i.2Urobilinoger
rot.
Cl-
6
pH
4.5
mg %
Zholester.
Na
114
DEPARTMENT
lo3
x mm3
proth.
sec.
0.2
725
a.5
CRF
TOXICOLOGICAL
nalytic
N.
1IV
card
/SEX
I
F
/STRAIN
IBeaole
115
DEPARTMENT
f EXPERIMENT
026
f
] TREATMENT
11 Img/Kg
i.v.-
1 month
BIOCHEMISTRY
HEMATOLOGY
BLOOD
URINE
:02
meq/l
Tot.
prot.
20
g %
Albumine
In.
g %
phos.
mg %
Cholester.
Crlucose
mg %
mg %
l
BUN mg %
rot.
bilirub.mg%
Alk.
phos.
mU/ml
pH
Htc
5
mg %#
%
45
3
7.9
Prot.
4
Glucose
Hb g % ml
836
Ketones
Erythr.
140
Bilirubin
MCV
70.3
115
Blood
Leukocytic
Formula
Neutoph.
52
14,6
Urobimoger
0,4
Sediment
iO5
P.S.
Leukoc-.
x
x
10
10,2
IO6
6,4
L
Of1
NN
1 n12 Lynph.
46
Monocytes
-_
Eos&wh
.
"p.'
0
SGOT mU/ml
Basbph.
0
Cl-
meq/l
Reticu1.x
Na+
meq/l
Plat.
K+
meq/l
T.
LDH mU/ml
230
SGPT mu/ml
20
Ca++ mg %
Date
27/9/?6
2
IO3
x mm3
proth.
set,
0;9
455
9
7
CRF
TOXICOLOGICAL
Analytic
N.
2 IV
card
SEX
F
116
DEPARTMENT
EXPERIMENT
026
STRAIN
Beagle
TREATMENT
i.v.-
lo( lmg/Kg
BIOCHEMISTRY
I
1 month
Htc
%
MCV
HEMATOLOGY
3LOOD
URINE
22
:02 meq/l
rot.
prot.
g %
4lbumine
In.
g %
phos.
Zholester.
>lucose
3UN
rot.
Alk.
mg %
mg % '
7,3
Prot.
3.5
Glucose
6,,
mg %
9
105
mu/ml
30
mg %;
Urobilinoger
x
++
0.1
I?
1.04
,P.S.
lo3
4% ml
Erythr.
n~.c;Sediment
105
Leukock
Hb g
-
Ketones
-Blood
2
bilirub.mg%
5
Bilirubin
loo
mg %
phos.
pH
x IO6
Leukocytic
Formula
Neutoph.
76
I-Lynph.
,DH mu/ml
Wonocytes
jGPT mu/ml
Eosinoph.
3GOT mu/ml
Basoph.
31- meq/l
Vat
meq/l
K+
meq/l
T.
!
Date
27/g/76
I
1
proth.
sec.
CRF
117
TOXICOLOGICAL
nalytic
N.
3 IV
card
SEX
F
DEPARTMENT
STRAIN
B eagle
EXPERIMENT
026
TREATMENT
m.g/Kg i.v.-
1 month
BIOCHEMISTRY
HEMATOLOGY
BLOOD
UI?INE
21
meq/l
co2
Tot.
prot.
g %
Albumine
In.
g %
phos.mg%
Cholester.
Glucose
mg $
mg %
l
Tot.
bilirub.mg$
Alk.
phos.
Hb g % ml
7.3
etones
Erythr.
125
ilirubin
WV
67.1
115
lood
ediment
Leukocytic
Formula
Neutoph.
49
.S.
Lynph.
robilinoger
Leukoci
Monocytes
mu/ml
40
Eosinoph.
SGOT mu/ml
55
Basoph.
SGPT
cl-
meq/l
L 139
Na+
meq/l
163
K+
meq/l
Ca
++
w
I
r
Date
2?/9/76
575
13,9
74
8
lucose
1105
mlJ/ml
3
399
mg Xi
250
LDH
51
Q
rot.
0,s
mu/ml
30
4tc
7,s
15,3
BUN mg %
6
'I
x
x
10
15,6
7,6
106
42
6
(
3
.
Reticu1.x
Plat.
T.
10
x mm3
proth.
set
3
0
0,9
.
295
9,s
I
CRF
TOXICOLOGICAL
ialytic
v.
card
SEX
1V
M
118
DEPARTMENT
STRAIN
Reaele
EXPERIMENT
026
TREATMENT
ai.v.-
Fhysiol.
sol.
1 month
BIOCHEMISTRY
HEMATOLOGY
BLOOD
Z02
URINE
meq/l
rot.
20
prot.
g %
4lbumine
In.
Prot..mg
g 46
phos.
mg %
Yholester.
Slucose
mg %
mg %
8
FH
%i
30
Htc
%
51
Leukocb
x
GLucose
Hb g % ml
Ketones
Erythr.
x
l
rot.
bilirub.mg$
RE
Alk.
phos.
l,Q
Lynph.
Urobilinogen
mU/ml
70
28
LDH mU/ml
Monocytes
SGPT
Eosinoph.
mlJ/ml
K+
Ca++
n
2
Basoph.
SGOT mu/ml
t
7.2
lo6
70.8
Leukocytic
Formula
Neutoph.
Na
16
Bilirubin
BUN mg %
cl-
75
IO3
meq/l
147
Reticu1.x
meq/l
151
Plat.
5,2
meq/l
T.
0
10
3
x mm3
proth.
set,
0.3
360
9
13,9
tn.52 %
q
1
I
Date
27/g/76
_-...
-
CRF
TOXICOLOGICAL
119
DEPARTMENT
HEMATOLOGY
3lbumine
g %
Zholester.
mg %
BUN
mg %
Alk.
phos.
LDH
SGPT
mU/ml
mu/ml
mU/ml
SGOT mU/ml
T.
Date
27/g/76
proth.
sec.
CRF
TOXICOLOGICAL
alytic
card
SEX
M
'3 v
STRAIN
Beavle
120
DEPARTMENT
TREATMENT
ei.v.-
EXPERIMENT
026
physiol.
sol.
1 month
BIOCHEMISTRY
HEMATOLOGY
lLOOD
URINE
:02 meq/l
24
PH
tr.
3
7
Htc
-i49
%
eukocl
rlbumine
x 10
:rythr.
mg %
Bilirubin
O,l
NN
41k.
phos.
mU/ml
13,4
l.n3;
x 10
896
57,o
.eukocytic
Tormula
leutoph.
48
,ynph.
44
lonocytes
SGPT mu/ml
Zosinoph.
SGOT mu/ml
aa'soph.
Plat.
T.
0
8
0-
Reticu1.x
lo3
x mm3
proth.
sec.
J
27/g/76
6
ICV
LDH mu/ml
Date
8.4
:b g $ ml
g %
:hol&ster.
3 t1
F
9
1 Ii
CRF
71
,
/ i
TOXICOLOGICAL
AI 'lalytic
+1rl.
card
SEX
1 VI
t
121
DEPARTMENT
STRAIN
Beaele
F
EXPERIMENT
026
TREATMENT physiol.
m
sol.
1 month
i.v.-
BIOCHEMISTRY
HEMATOLOGY
t3LOOD
URINE
I
302
meq/l
rot.
13
prot.
g %
4lbumine
In.
g %
phos.
Glucose
mg %
mg %
l
BUN mg %
bilirub.mg$
Alk.
ohos.
SGPT
mu/ml
SGOT mu/ml
Cl-
meq/l
Na+ meq/l
u+ meq/l
Ca
++
5,7
Prot..mg
691 Ketone:.
110
85
.Bilirubin
mU/ml
n 7 Sediment
!105
220
itc
51
%
,eukoci
Ii
-
x 10
P.S.
_
40
7.4
15,4
Ib g % ml
srythr.
x 10
6
794
KV
69.9
Leukocytic
Formula
Neutoph.
65
Lynph.
35
0
Monocytes
0
Eosinoph.
50
Basoph.
---I
Reticu1.x
142
175
3
1
Plat.
T.
_ 6
lo3
n4
280
x mm3
QrOth.
995
set
m.c %
,
Date
27/g/76
1
<Blood
18 LUrobilinogen
Tot.
LDH mU/ml
pH
s..xGlucose
mg %
Cholester.
I
i
I
I
CRF
TOXICOLOGICAL
22
DEPARTMENT
aq&i@
1 month
i-v.-
BIOCHEMISTRY
HEMATOLOGY
;LOOD
:02
URINE
meq/l
19
'ot . prot.
g %
hlbumine
In.
g %
phos.
mg %
:holestdr.
mg %
;lucose
mg %
7
PH
7.3
Prot.
3.9
Glucose
6;l
Ketones
mg 46;
30
Bilirubin
l
Leukocytic
Formula
Neutoph.
41k.
phos.
mU/ml
al Lynph,.
LDH mU/ml
Monocytes
SGPT
Eosinoph.
mU/ml
Basoph.
SGOT mU/ml
Reticu1.x
Plat.
T.
!
Date
27/g/76
10
3
x mm3
proth.
sec.
CRF
TOXICOLOGICAL
Analytic
N.
I 3 VI
card
f SEX
F
I
[STRAIN
IBewle
123
DEPARTMENT
1 EXPERIMENT
1
026
1
I
TREATMENT
mg&kg
i.v.-
Physiol.
Sol.
1 month
BIOCHEMISTRY
HEMATOLOGY
3LOOD
URINE
:02 meq/l
6
prot.
rot.
ilbumine
In.
tr
g %
g %
phos.
;lucose
mg %
mg %
l
bilirub.mg'
41k.
phos.
50
,eukock
x 10
crythr.
115
mU/ml
Or6
robilinogel
adiment
.S.
NN
aeukocytic
pormula
leutoph.
20
Lynph.
SGPT mu/ml
35
Eosinoph.
SGOT mu/ml
65
Basoph.
meq/l
126
Reticu1.x
Na+ meq/l
166
Plat.
ca++
m.g %
Date
27/g/76
8
Load
tionoc;ytes
meq/l
6
62,5
270
K+
795
14
x 10
LDH mU)ml
cl-
3
ilirubin
3
115
13,8
3UN mg %
rot.
%
Ib g % ml
mg %
Zholester.
kc
5,6
T.
0
10
.
IO3
x mm3
proth.
set
0
0.4
785
10
12
-
:.
CRF
TOXICOLOGICAL
,-Al 7alytic
Iv.
11
card
SEX
M
STRAIN
Be a?le
124
DEPARTMENT
EXPERIMENT
026
TREATMENT
20 Cmgi'Kg
i.v.-
I
TIME 0
BIOCHEMISTRY
HEMATOLOGY
4
tr
llbumine
In.
g %
phos.
3
12,2
10.8
x
6.5
lo6
mg % '
Tot.
bilirub.mg%
Alk.
phos.
Lynph.
mu/ml
mU/ml
10
Eosinoph.
SGOT
mU/ml
Basoph.
cl-
meq/l
Reticu1.x
Na+
meq/l
Plat.
K+
meq/l
T.
077
lo3
1,14c
x mm3
proth.
695
set
%
1
27/g/76
46
2
mu/ml
wz
42
Nonocytes
SGPT
Date
10
g % ml
Leukocytic
Formula
Neutoph.
LX++
x
WV
BUN mg %
LDH
44-l
Zrythr.
mg %
Glucose
$
,eukoci
ib
mg %
Cholester.
Itc
I
CRF
TOXICOLOGICAL
125
DEPARTMENT
mg/Kg
i.v.-
Tm
0
BIOCHEMISTRY
HEMATOLOGY
URINE
BLOOD
co2
Tot.
"
meq/l
prot.
I
pH
7*B Prot.
g 46
mg %;.
6
itc
-
Leukocs
42
A
9.2
x IO3
12.4
3b g % ml
Erythr.
Cholester.
Bilirubin
mg %
phos.
S2.0
WV
Leukocytic
Formula
Neutoph.
BUN mg %
Alk.
mu/ml
'
l--=-l
I---
40
Wonocytes
SGPT mu/ml
25
Eosinoph.
SGOT mu/ml
55
Basoph.
Cl-
meq/l
130
va+
meq/l
It%
K+
meq/l
T.
8
l-l7
IO3
750
x mm3
proth.
7.9
set
12,8
!
27/Q/76
Plat.
LA.2
0
Reticu1.x
_
6,1
ca++m.Q %
40
E: Lynph.
P.S.
LDH mU/ml
Date
7
x IO6
1
J
/
CRF
TOXICOLOGICAL
126
DEPARTMENT
HEMATOLOGY
rot.
prot.
4lbumine
In.
g ‘%
Prot.
g %
phos.
Glucose
mg %
Zholeste_r.
Ketones
mg '%
ICV
Urobilinogen
BUN mg 4'.
Sediment
41k.
phos.
-
mg %;
mu/ml
6-31
-#i---
Leukocytic
Formula
Jeutoph.
,ynph.
LDH mu/ml
\
SCPT &I/ml
donocytes
SGOT mu/ml
Basoph.
Cl-
meq/l
Reticu1.x
Na+
meq/l
K+
meq/l
Ca
t+
Eosinoph.
134
b.4
12
mg %
27/9/76
Plat.
T.
t-
Date
44
I--
lo3
x mm3
proth.
sec.
1 n
CRF
TOXICOLOGICAL
Analytic
N.
1 II
card
SEX
F
127
DEPARTMENT
EXPERIMENT
026
STRAIN
Beaole
TREATMENT
,m,q/Kg i.v.-
2
TIME 0
BIOCHEMISTRY
HEMATOLOGY
BLOOD
j-j
ii ai
URINE
co2
meq/l
Tot.
prot.
_ Iate
In.
g %
phos.
Glucose
IHb
mg %
mg %
x IO3
g % ml
Erythr.
mg 4%
Cholester.
1
i
1Leukack
g %
Albumine
%
x
IO6
MCV
l
BUN mg %
1Leukocytic
iFormula
'ot . bilirub.mg%
-i Neutoph
,lk.
c 1Lynph.
phos.
mu/ml
.
2
1Uonocytes
.DH mU/ml
I--
i I
;GPT mu/ml
Eosinoph.
iGOT mu/ml
Basoph.
'
:I-
Reticu1.x
IO3
meq/l
$a+ meq/l
Plat.
<+
T.
meq/l
Ca++ rng %
I
Date
27/g/76
j
i
I
x mm3
proth.
sec.
1
CRF
TOXICOLOGICAL
128
DEPARTMENT
HEMATOLOGY
3LOOD
:02 meq/l
rot.
prot.
g 4%
L\lbumine
:n.
g %
phos.
mg %
:holester.
ilucose
mg %
mg %
l
3UN mg %
Bilirubin
Blood
Urobilinogen
rot.
bilirub.mg?
t-w
&ukocytic
Tormula
Geutoph.
Ilk.
phos.
1,035
Lynph.
0,l
mu/ml
5.f;
44
:DH mu/ml
tionocytes
0
3GPT mu/ml
Eosinoph.
0
SGOT mu/ml
Basoph.
n
Cl-
meq/l
Reticu1.x
Na+
meq/l
Plat.
K+
meq/l
T.
Ca
++
,225
7
sec.
rn.-z %
Date
x mm3
proth.
l,o
IO3
27/9/76
j_
I
CRF
TOXICOLOGICAL
.-An ialytic
NI.
3 II
-
card
SEX
129
DEPARTMENT
F
T
TREATMENT
00 mg/Kg
i.v.-
EXPERIMENT
026
STRAIN
Beagle
BIOCHEMISTRY
TM0
Itc
%
c
HEMATOLOGY
ILOOD
URINE
I
:02
meq/l
'ot
. prot.
I
g 4b
blbumine
mg %;
,eukoc;
g %
fb
:n.
x
mg %
mg 74
ilucose
Bilirubin
3
g % ml
Srythr.
Jholester.
10
x
IO6
VlCV
l
3UN mg %
Urobi&nogen
rot.
091
Leukocytic
Formula
Neutoph.
59
I--
4lk.
,DH
phos.
mU/ml
Lynph.
mu/ml
Monocytes
SGPT mu/ml
Eosinoph.
SGOT mu/ml
Basoph.
Cl-
meq/l
121
Reticu1.x
Na+
meq/l
120
Plat.
10
350
x mm3
I---
K+
Cat+
4
meq/l
proth.
7,
sec.
11,9
m.q %
LB
f
Date
T.
27/g/76
i
-.
/
CRF
TOXICOLOGICAL
Analytic
'N.
1
card
SEX
III
M
130
DEPARTMENT
STRAIN
Beagle
EXPERIMENT
026
TREATMENT
i.v.20C)mg/Kg
BIOCHEMISTRY
t BLOOD
19
prot.
g %
Albumine
In.
g %
phos.
mg
Cholester.
Glucose
%
mg %
mg % '
BUN mg %
Tot.
HEMATOLOGY
URINE
CO2 meq/l
Tot.
1
TIME 0
9.5
.PH
.Prot.
4;~
Glucose
10;5
.Ketones
115
.Bilirubin
L55
Blood
-Urobi
bilirub.mg4
0,3
mg %;
6
titc %
tr
Leukoc;
x
lo3
Hb g % ml
-
-
Erythr.
x
lo6
MCV
linogen
CIl
NN
Sediment
Leukocytic
Formula
Neutoph.
33
I-
Alk.
LDH
phos.
mu/ml
SGPT
mu/ml
SGOT
mu/ml
mu/ml
L80
P.S.
1.c14(
Ho
Lynph.
Monocytes
35
Eosinoph.
70
Basoph.
cl-
meq/l
131
Reticu1.x
Na+
meq/l
123
Plat.
Kf
meq/l
10
3
550
x mm3
I-
ca++
4,1
T.
12
t-n.- %
I
I
I
Date
27/g/76
proth.
sec.
CRF
TOXICOLOGICAL
3aIytic
4.
2 III
card
SEX
STRAIN
Bea&.e
M
131
DEPARTMENT
TREATMENT
lOOmg/Kg
i.v.-
EXPERIMENT
026
TIME0
BIOCHEMISTRY
f
5
-ftc
%I
41
Leukoc%
-
Albumine
HEMATOLOGY
x
Srythr.
mg 4%
phos.
LDH
Urobilinogel
mU/ml
1
mU/mI
Leukocytic
Formula
Neutoph.
51
Lynph.
42
Monocytes
5
2
mu/ml
Eosinoph.
SGOT
mU/mI
Basoph.
0
Reticu1.x
Plat.
T.
15
I----
++
mp: %
I
/
Date
27/g/76
-!50,.?
(
SGPT
Ca
6.8
106
l
BUN mg %
Alk.
x
dCV
mg %
Zlucose
11,8
Hb g % ml
g %
Zholester.
103
0,8
lo3
675
x mm3
proth.
set
I
7
CRF
TOXICOLOGICAL
132
DEPARTMENT
HEMATOLOGY
Leukoci
\lbumine
10
g %
:holester.
mg %
Ilk.
mU/ml
;DH
x
phos.
mu/ml
Bilirubin
Monocytes
SGPT mu/ml
SGOT mu/ml
Reticu1.x
10
I
Date
27/9/76
CRF
TOXICOLOGICAL
nalytic
N.
1 IV
card
SEX
133
DEPARTMENT
STRAIN
Beaele
TREATMENT
00 mg/Kg i.v.-
EXPERIMENT
026
TIME0
BIOCHEMISTRY
HEMATOLOGY
BLOOD
URINE
I
I
' I
6
itc
46
Leukoci
Albumine
g 46
x 10
Glucose
mg %
mg $
phos.
Urobi&nogen
mU/ml
NN
Leukocytic
Formula
Neutoph.
1,025
Lynph.
0.1
25
SGOT mU/ml
75
Basoph.
meq/l
129
Reticu1.x
Na+ meq/l
132
Plat.
67
30
1
Eosinoph.
T.
12 6
12,6
I-I
27/Q/76
_
4.&,.-
meq/l
ca++ m.c
74
ca++
m.c 74
Date
6
Monocytes
SGPT mu/ml
K+
x 10
l
LDH mU/ml
Cl-
12,6
Bilirubin
BUN mg %
Alk.
a.4
jb g % ml
Zrythr.
Cholester.
3
iI
I
0
10
x mm3
proth.
set
3
0;8
700
7.3
CRF
TOXICOLOGICAL
Alnalytic
N.
2
card
SEX
IV
134
DEPARTMENT
EXPERIMENT
026
STRAIN
Beaele
1
TREATMENT
100
BIOCHEMI,STRY
t-
iLOOD
URXNE
I
ilbumine
I
-
I
g %
6
ftc
tr.
.eukoci
ib
%
x
mg 46
l
Urobilinoger
phos.
*eukoc
?ormula
Yeutoph.
503
vlonocytes
SGPT mu/ml
65
SGOT mu/ml
85
Basoph.
Eosinoph.
Cl--
meq/l
129
Reticu1.x
Nat
meq/l
139
Plat.
K+
meq/l
Ca++
mg
tic
Lynph.
mU/ml
LDH mu/ml
lo6
'
3UN mg %
41k.
x
acv
mg %
;lucose
3
g % ml
?.rythr.
:holester.
10
T.
'
10
3
x mm3
proth.
sec.
%
II-=
Date
27/g/76
CRF
TOXICOLOGICAL
” nalytic
IN.
3 IV
card
SEX
F
STRAIN
Beagle
135
DEPARTMENT
EXPERIMENT
026
TREATMENT
loo mg/Kg i.v.-
TIME0
BIOCHEMISTRY
BLOOD
URINE
I
-
1
7
tr
Albumine
I-Itc
%
45
1Leukoc)
-
g %
HEMATOLOGY
x 10
Glucose
BUN
mg %
mg %
Bilirubin
7
mg %
phos.
x lo6
hICV
64,3
-0:l
Leukocytic
?ormula
rleutoph.
61
mU/ml
.,03E;
Lynph.
LDH mu/ml
Honocytes
SGPT mu/ml
Eosinoph.
SGOT mu/ml
Basoph.
‘0
Reticu1.x
Plat.
T.
Date
27/g/76
7
l
I-w
Alk.
I
8.2
14.3
1Hb g % ml
f Srythr.
Cholester.
3
lo3
x mm3
proth.
sec.
0.6
CRF
TOXICOLOGICAL
136
DEPARTMENT
BIOCHEMISTRY
HEMATOLOGY
BLOOD
Z02
I
Htc
prot.
g %
Albumine
b\lIOt.
g %
phos.
mg %
Cholester.
Glucose
mg
.mg
g 3
Ketones
Erythr.
%
145
Blood
IO,3
bilirub.mg%
Ilk.
phos.
071
Sediment
NN
Leukocytic
Formula
Neutoph.
40
Lynph.
56
k20
1,035
p .s .
>
225
Monocytes
35
Eosinoph.
3GOT mU/ml
55
Basoph.
meq/l
,140
Na+meq/l
K+
ca++mg
Plat.
574
%
T.
13,l
I
Date
27/9/?6
‘0-
Reticu1.x
.
150
meq/l
7
Urobilinogen
SGPT$mU/ml
El-
lo6
MCV
>
mu/ml
x
lo3
-
0,6
mu/ml
x
Hb g % ml
Bilirubin
Tot.
Leukocb
*ik
Glucose
175
l
48
%
4,7
mg %
BUN mg %
;DH
I
meq/l
Tot.
In.
URINE
1
IO3
x mm3
proth.
sec.
0,6
425
8
CRF
TOXICOLOGICAL
nalytic
card
SEX
N.
2
v
STRAIN
M
137
DEPARTMENT
EXPERIMENT
Be-e
TREATMENT physiol . ~01.
m
i.v.TIME0
026
BIOCHEMISTRY
t
HEMATOLOGY
BLOOD
URINE
CO2 meq/l
Tot.
prot.
g %
Albumine
In.
8 6.Prot.
g %
phos.
4~5
mg %
Choleste-r.
Glucose
mg %
mg $
41k.
l
LDH mU/ml
SGPT
mu/ml
Glucose
170
-Bilirubin
1.15
Blood
10~7
bilirub.mg!
phos.
Urobi&noger
Of5 ,Sediment
mU/ml
mg $
8~7.Ketones
3UN mg %
rot.
8
.-r-/i--
,
:
-P.S.
x-n
35
Htc
$
Leukoc;
x
Hb g % ml
Erythr.
x
46
Lynph.
42
Monocytes
8
Eosinoph.
0
Cl-
meq/l
Reticu1.x
Na+
meq/l
Plat.
K+
meq/l
T.
Date
2?/9/76
7,6
Neutoph.
Basoph.
mp: %
lo6
Leukocytic
Formula
SGOT mU/ml
Ca++
lo3
.4
lo3
x mm3
proth.
set
6.4
415
8.5
.
I
CRF
‘1
: i
1i
TOXICOLOGICAL
AI
.- lalytic
rJ
'3 v
{1 1/
: :
1 I
I
DEPARTMENT
card
SEX
t
M
TREATMENT
EXPERIMENT
026
STRAIN
Beaule
HEMATOLOGY
tURINE
I
: i
i
302
meq/l
rot.
23
prot.
g %
L\lbumine
8.8
g %
5
.PH
.Prot.
mg %;
6
[tc
tr
‘eukoct
Glucose
%
43
x
In.
phor..
"holester.
BUN
:
j
1
:
mg %
.
1.45
l
12,2
mg %
rot.
bilirub.mg9
Alk.
phos.
LDH
2!DO
mg %
>lucose
: i
9;4
mg %
mU/ml
mu/ml
&-
0.4
i50
I150
:rythr.
.Ketones
_
13
x
10 6
.Blood
Urobilinoger
Sediment
-P.S.
NIV
1.025
,eukocytic
Formula
ieutoph.
,ynph.
,
lonocytes
cosinoph.
SGOT
mu/ml
3asoph.
cl-
meq/l
ieticu1.x
Na+
meq/l
'lat.
K'.
medl
r.
IO3
x mm
proth.
3
sec.
-.
I
Date
27/g/76
7.2
896
990
mU/ml
mp: %
3
ICV
Bilfrubin
SGPT
ca++
10
lb g 4% ml
: )
i i
PhySiOl.
Sol.
TIME0
l%g@Wg i.v.-
BIOCHEMISTRY
3LOOD
-
i
138
1
CRF
TOXICOLOGICAL
l-39
DEPARTMENT
B
C
T
A lbumine
I n.
g %
phos.
mg %
C'holester.
mg %
G
B
'I
P
I ,DH mu/ml
c. jGPT
mu/ml
2jGOT
mU/ml
(
I
T.
1
Date
27/g/76
proth.
sec.
CRF
TOXICOLOGICAL
alytic
i
card
SEX
VI
STRATN
Be&e
F
140
DEPARTMENT
EXPERIMENT
026
TREATMENT
physiol.
sol.
i.v.TIME0
I-
BIOCHEMI,STRY
HEMATOLOGY
lLOOD
URINE
I
:02
meq/l
‘ot.
prot.
I
27
7
pH
+Htc
45
%
t-i
g
hlbumine
Prot
%
g %
:n. phos.
..mg
.eukoc:;
%
Glucose
Trythr.
mg %
Zlucose
mg
%
3
ibg%ml
mg %
Jholester.
x 10
Y 106
llcv
l*
3UN mg %
0.1
rot.
bklirubimg
NN
Leukocytic
Formula
Neutoph.
41k.
phos.
1,025
WM.
mU/m
LDH mu/ml
Monocytes
'\
SGPT mu/ml
Eosinoph.
I
SGOT &J/ml
Cl-
meq/l
Va+ meq/l
K+
154
T.
meq/l
w
Ca++
14 5
mg %
t-
Date
27/g/76
proth.
sec.
4
CRF
TOXICOLOGICAL
talytic
I.
card
SEX
F
z-4VT
141
DEPARTMENT
TREATMENT
*i.v.-
EXPERIMENT
026
STRAIN
Beagle
Physiol.
sol.
TIME0
I
BIOCHEMISTRY
HEMATOLOGY
URINE
LOOD
O2
meq/l
ot.
22
prot.g%
lbumine
I
g %
.PH
898
Prot.
4,s
Glucose
I
t-? phos.
mg %
:holester.
Be2
>
.mg %I
Ketones
mg %
Leukocytic
jlk.
,DH
phos.
mU/ml
mu/ml
SGPT mu/ml
SGOT mU/ml
Plat.
T.
410
x mm3
proth.
sec.)
I
Date
2?/9/76