Nianjun Liu Curriculum Vitae Contact Information

Nianjun Liu
Curriculum Vitae
Contact Information
Department of Biostatistics
Ryals Public Health Bldg, 420A
University of Alabama at Birmingham
Birmingham, AL 35294
Phone:
(205) 975-9190
Fax:
(205) 975-2540
E-mail:
[email protected]
Education
May 2005
Ph.D., Biostatistics
Department of Epidemiology and Public Health, Yale University
Dissertation Title: Statistical Methods for Haplotype Analysis in Genetic
Studies
Committee: Theodore R. Holford, Hongyu Zhao, Kenneth K. Kidd
May 2003
M.Phil., Biostatistics
Department of Epidemiology and Public Health, Yale University
Jul 1993
M.S., Applied Mathematics
Peking University, Beijing, China
Jul 1990
B.S., Computational Mathematics
Peking University, Beijing, China
Current Employment
•
Primary Appointment
Associate professor
•
Department of Biostatistics, the University of Alabama at Birmingham
Secondary Appointment
Assistant professor
Division of Pulmonary, Allergy and Critical Care Medicine,
Department of Medicine, the University of Alabama at Birmingham
Professional Experience
Oct 2010 – present
Associate Professor (tenured), Department of Biostatistics, the
University of Alabama at Birmingham
Apr 2015 – present
Director of Graduate Programs, Department of Biostatistics, the
University of Alabama at Birmingham
Aug 2012 – present
Associate Director, UAB Statistical Genetics Post-doctoral Training
Program (funded by NHLBI T32HL072757)
Jan 2010 – present
Assistant Professor, Division of Pulmonary, Allergy and Critical Care
Medicine, Department of Medicine, the University of Alabama at
Birmingham
Aug 2005 – Sep 2010
Assistant Professor, Department of Biostatistics, the University of
Alabama at Birmingham
Feb 2003 – Jul 2005
Research Assistant, Department of Epidemiology and Public Health,
Nianjun Liu
Curriculum Vitae
Yale University
Jun 2004 – Jul 2005
Consultant, University of Connecticut Health Center, Farmington, CT
Jan 2004/2001 – May
2004/2001
Teaching Assistant, Department of Epidemiology and Public Health,
Yale University
Sep 2002 – Feb 2003
Research Assistant, Department of Genetics, Yale University
Nov 2001 – Sep 2002
Research Assistant, Connecticut Mental Health Center and Department
of Psychiatry, Yale University
Sep 2000 – Dec 2001
Statistical Lab Tutor, Department of Epidemiology and Public Health,
Yale University
Aug 1998 – Jun 1999
Researcher, China Academic Library and Information System
Administration Center, Peking University, China
Jul 1993 – Aug 1998
Researcher & Software Engineer, Institute of Computer Science and
Technology, Peking University
Nov 1994 – Dec 1995 Draftsman, participation in creating the China national standard: Chinese
Internal Code Specification (abbreviated as GBK)
Sep 1990 – Jul 1992
Teaching Assistant, Department of Mathematics, Peking University,
China
Oct 1989 – Jun 1990
Research Assistant, Department of Mathematics, Peking University,
China
Research Interests
•
Statistical genetics and genomics: Genetic linkage and association analysis, disequilibrium
mapping, haplotype analysis, population genetics, genome-wide-association studies and nextgeneration sequencing data analysis, pharmacogenomics, bioinformatics, risk prediction, and
personalized medicine.
•
Statistics/Biostatistics: Longitudinal data analysis, survival analysis, missing data problems
and imputation methodology, prediction, machine learning methods, big data, cluster and
classification, and their applications in genetics and bioinformatics.
Professional Memberships
American Statistical Association
Institute of Mathematical Statistics
American Society of Human Genetics
International Genetic Epidemiology Society
Teaching Activities
Course Instructors
• 2015 (Dept of Biostatistics, University of Alabama at Birmingham)
o Statistical Computing with R
o Intermediate Statistical Analysis II
• 2014 (Dept of Biostatistics, University of Alabama at Birmingham)
o Advanced Computational Methods
Page 2/16
Nianjun Liu
•
•
•
•
•
•
•
Curriculum Vitae
o Non- Dissertation Research
2013 (Dept of Biostatistics, University of Alabama at Birmingham)
o Statistical Computing with R
o Non- Dissertation Research
2012 (Dept of Biostatistics, University of Alabama at Birmingham)
o Advanced Computational Methods
o Non- Dissertation Research
2011 (Dept of Biostatistics, University of Alabama at Birmingham)
o General Linear Models
o Non- Dissertation Research
o Non- Thesis Research
2010 (Dept of Biostatistics, University of Alabama at Birmingham)
o General Linear Models
o Non-Thesis Research
o Intermediate Statistical Analysis II
2009 (Dept of Biostatistics, University of Alabama at Birmingham)
o General Linear Models
o Statistical Consulting
2008 (Dept of Biostatistics, University of Alabama at Birmingham)
o General Linear Models
o Non-Thesis Research
o Statistical Consulting
2007 (Dept of Biostatistics, University of Alabama at Birmingham)
o General Linear Models
Invited Lectures
• 2013
o Statistical Methods for Genetic Analysis I (Dept of Biostatistics, University of
Alabama at Birmingham)
 Three lectures on genotype imputation, population structure and admixture,
and genetic association analysis in families and structured samples
• 2012
o Genetics and Genomics in Clinical Research - An Immersion Course for Clinical
Investigators at UAB (The University of Alabama School of Medicine)
 One lecture on design and analysis of genetic association studies
• 2009
o Statistical Methods for Genetic Analysis II (Dept of Biostatistics, University of
Alabama at Birmingham)
 One lecture on haplotype analysis
• 2007
o Introduction to Statistical Genetics (Dept of Biostatistics, University of Alabama at
Birmingham)
 One lecture on haplotype analysis
o Quantitative Methods (Hughes Med-Grad Fellowship Didactic Program, University
of Alabama at Birmingham)
 One lecture on pharmacokinetics statistics
• 2006
o Principles of Genetics/Genetic Basis of Disease (Dept of Genetics, University of
Alabama at Birmingham)
 One lecture on genetic association analysis
Page 3/16
Nianjun Liu
Curriculum Vitae
Teaching Assistants
•
•
•
•
2004 (Department of Epidemiology and Public Health, Yale University)
o Statistical Thinking
2001 (Department of Epidemiology and Public Health, Yale University)
o Statistical Thinking
o Statistical Lab Tutor
2000 (Department of Epidemiology and Public Health, Yale University)
o Statistical Lab Tutor
1990 – 1992 (Department of Mathematics, Peking University, China)
o Calculus, Advanced Algebra and C Programming Language
New Courses Developed
•
Statistical Computing with R
Current Advisees
•
•
Postdoctoral Fellow
o
M.S. Student
o
Past Advisees
•
•
•
•
•
Postdoctoral Fellows
o Michael Sandel, co-mentor (primary mentor: Scott Ballinger and Hemant Tiwari),
Oct 2012 –2015 (Currently Assistant Professor, Department of Biological and
Environmental Sciences, College of Natural Sciences and Mathematics, The
University of West Alabama, AL)
o John Dawson, co-mentor (primary mentor: David Allison), Oct 2012 – July 2014
(Currently Assistant Professor, Department of Nutrition Sciences, Texas Tech
University, Lubbock, TX)
o Wan-Yu Lin, Aug. 2010 – July 2012 (Currently Assistant Professor, National
Taiwan University)
o Boshao Zhang, June 2009 – May 2011 (Currently Biometrician, Merck, Beijing)
o Guo-Bo Chen, co-mentor (primary mentor: Xiang-Yang Lou), Mar 2010 – Aug
2011 (Currently postdoctoral fellow, the University of Queensland )
o Kofi Adragni, co-mentor (primary mentor: David Allison), Oct 2009 – Aug 2010
(Currently Assistant Professor, University of Maryland Baltimore County)
Ph.D. Student
o Qi Yan, primary mentor (co-mentor: Nengjun Yi), Aug. 2011 – June 2014
(Currently postdoctoral fellow, University of Pittsburgh)
Ph.D. Committee Member and Reader
o Jun Li, Biostatistics, University of Alabama at Birmingham, Dec 2010 – Dec 2011
Ph.D. Academic Advisors
o Yan Li, academic advisor, Biostatistics, Aug. 2014 –Dec. 2014
o Peng Li, academic advisor, Biostatistics, Aug. 2011 – July 2012
o Samantha Seals, academic advisor, Biostatistics, Oct 2008 – Sep 2011
M.S. Committee Member and Thesis Advisor
Page 4/16
Nianjun Liu
•
•
Curriculum Vitae
o Fenglong Xie, Aug 2007 – Dec 2008. (Master project: Are SNPs in FCAR
Associated with SLE?)
o Qi Yan, Aug 2009 – May 2011. (Master project: The Effect of Racial Difference
on Warfarin Dose Response and Hemorrhagic Complications)
o Peng Li, Aug 2009 – May 2011. (Master project: Reanalysis of an Obesity Dataset
Using a New Gene-based Method)
M.S. Academic Advisors
o Yi Xu, academic advisor, Biostatistics, Aug. 2014 –April 2015
o Yan Li, Aug. 2012 – May 2014
M.S. Committee Members
o Guodong Wu, 2010
o Justin T. Arcury, 2007
Publications
Peer Reviewed (current/former trainees and corresponding author*)
1.
N. Liu, S.L. Sawyer, N. Mukherjee, A.J. Pakstis, J.R. Kidd, K.K. Kidd, A.J. Brookes, H.
Zhao (2004) Haplotype Block Structures Show Significant Variation among Populations.
Genetic Epidemiology 27: 385-400.
2.
G. Sanacora, R.M. Berman, A. Cappiello, D. Oren, A. Kugaya, N. Liu, R. Gueorguieva, D.
Fasula, D. Charney (2004) Addition of the α2-Antagonist Yohimbine to Fluoxetine:
Effects on Rate of Antidepressant Response. Neuropsychopharmacology 29: 1166-1171.
3.
J.H. Krystal, W. Abi-Saab, E. Perry, C. D’Souza, N. Liu, R. Gueorguieva, L. McDougall,
T. Hunsberger, A. Belger, L. Levine, A. Breier (2005) Preliminary Evidence of
Attenuation of the Disruptive Effects of the NMDA Glutamate Receptor Antagonist,
Ketamine, on Working Memory by Pretreatment with the Group II Metabotropic
Glutamate Receptor (mGluR) Agonist, LY354740, in Healthy Human Subjects.
Psychopharmacology 179: 303-309.
4.
N. Liu, L. Chen, S. Wang, C. Oh, H. Zhao (2005) Comparison of Single Nucleotide
Polymorphisms and Microsatellites in Inference of Population Structure. BMC Genetics
2005, 6(Suppl 1):S26.
5.
L. Chen, N. Liu, S. Wang, C. Oh, H. Zhao (2005) Whole Genome Association Studies in
Alcoholism Comparing Different Phenotypes Using Single-Nucleotide Polymorphisms and
Microsatellites. BMC Genetics 2005, 6(Suppl 1):S130.
6.
S. Wang, S. Huang, N. Liu, L. Chen, C. Oh, H. Zhao (2005) Whole-Genome Linkage
Analysis in Mapping alcoholism genes Using Single Nucleotide Polymorphisms and
Microsatellites. BMC Genetics 2005, 6(Suppl 1):S28.
7.
C. Oh, S. Wang, N. Liu, L. Chen, H. Zhao (2005) A Bayesian Genome Screening of
Maximum Number of Drinks as an Alcoholism Phenotype with the New Haseman-Elston
Method. BMC Genetics 2005, 6(Suppl 1):S116.
8.
S. Huang, S. Wang, N. Liu, L. Chen, C. Oh, H. Zhao (2005) Whole-Genome Scan in
Mapping Recombination Modifier Genes Using Single Nucleotide Polymorphisms and
Microsatellites. BMC Genetics 2005, 6(Suppl 1):S51.
9.
Y. Liu, N. Liu, H. Zhao (2005) Inferring protein-protein interactions through highthroughput interaction data from diverse organisms. Bioinformatics 21: 3279-3285.
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Nianjun Liu
Curriculum Vitae
10.
N. Liu, I. Beerman, R. Lifton, H. Zhao (2006) Haplotype Analysis in the Presence of
Informatively Missing Genotype Data. Genetic Epidemiology 30: 290–300.
11.
B. Wu, N. Liu, H. Zhao (2006) PSMIX: an R Package for Population Structure Inference
via Maximum Likelihood Method. BMC Bioinformatics 2006, 7:317.
12.
N. Liu, H. Zhao (2006) A Non-parametric Approach to Population Structure Inference
Using Multilocus Genotypes. Human Genomics 2(6): 353-364.
13.
D. Redden, J. Divers, L. Vaughan, H. Tiwari, M. Beasley, J. Fernandez, R. Kimberly, R.
Feng, M. Padilla, N. Liu, M. Miller, D. Allison (2006) Regional Admixture Mapping and
Structured Association Testing: Conceptual Unification and an Extensible General Linear
Model. PLoS Genet 2(8): e137.
14.
S. Wu, L. Leng, Z. Feng, N. Liu, H. Zhao, C. McDonald, A. Lee, F. Arnett, P. Gregersen,
M. Mayes, R. Bucala (2006) Macrophage Migration Inhibitory Factor Promoter
Polymorphisms and the Clinical Expression of Scleroderma. Arthritis and Rheumatism 54:
3661-3669.
15.
S. Musani, D. Shriner, N. Liu, R. Feng, C. Coffey, N. Yi, H. Tiwari, D. Allison (2007)
Detection of GenexGene Interactions in Genome-Wide Association Studies of Human
Population Data. Human Heredity 63:67-84.
16.
J. Arcaroli, J. Sankoff, N. Liu, D. B. Allison, J. Maloney, E. Abraham (2008) Association
between Urokinase Haplotypes and Outcome from Infection-Associated Acute Lung
Injury. Intensive Care Medicine 34:300–307.
17.
J.M. Kelley, L.B. Hughes, R. Feng, N. Liu, M.A. Padilla, L.K. Vaughan, S.L. Bridges
(2008) Evaluating Linkage Disequilibrium and Recombination Provides a Haplotypetagging SNP Panel of the Major Histocompatibility Complex in African Americans. Genes
and Immunity 9:271–273.
18.
N. Liu, K. Zhang, H. Zhao (2008) Haplotype-Association Analysis. Adv. Genet. 60:335405.
19.
N.A. Limdi, T.M. Beasley, M.R. Crowley, J.A. Goldstein, M.J. Rieder, D.A. Flockhart,
D.K. Arnett, R.T. Acton, N. Liu (2008) VKORC1 polymorphisms, haplotypes and
haplotype groups on warfarin dose among African–Americans and European–Americans.
Pharmacogenomics 9:1445-1458. PMCID: PMC2586955.
20.
W.K. Chung, A. Patki, N. Matsuoka, B.B. Boyer, N. Liu, S.K. Musani, A. Goropashnaya,
P.L. Tan, N. Katsanis, S.B. Johnson, P.K. Gregersen, D.B. Allison, R.L. Leibel, H.K.
Tiwari (2009) Analysis of 30 Genes (355 SNPS) Related to Energy Homeostasis for
Association with Adiposity in European-American and Yup’ik Eskimo Populations.
Human Heredity 67:193-205. PMCID: PMC2715950.
21.
N. Liu, D. Zhang, H. Zhao (2009) Genotyping Error Detection in Samples of Unrelated
Individuals without Replicate Genotyping. Human Heredity 67:154-162. PMCID:
PMC2782542.
22.
G. Kang, K. Ye, N. Liu, D. Allison, G. Gao (2009) Weighted Multiple Hypothesis Testing
Procedures. Statistical Applications in Genetics and Molecular Biology Vol. 8: Iss. 1,
Article 23 (DOI: 10.2202/1544-6115.1437). PMCID: PMC2703613.
Page 6/16
Nianjun Liu
Curriculum Vitae
23.
N. Liu, R. Bucala, H. Zhao (2009) Modeling Informatively Missing Genotypes in
Haplotype Analysis. Communications in Statistics – Theory and Methods 38(18): 3445 –
3460. PMCID: PMC2801447.
24.
G. Kang, D. Childers, N. Liu, K. Zhang, G. Gao (2009) Genome-wide association studies
of rheumatoid arthritis data via multiple hypothesis testing methods for correlated tests.
BMC Proceedings 2009, 3(Suppl 7):S38. PMCID: PMC2795936.
25.
D. Childers, G. Kang, N. Liu, G. Gao, K. Zhang (2009) Application of imputation methods
to the analysis of rheumatoid arthritis data in genome-wide association studies. BMC
Proceedings 2009, 3(Suppl 7):S24. PMCID: PMC2795921.
26.
N.A. Limdi, M. Wadelius, L. Cavallari, N. Eriksson, D.C. Crawford, M.M. Lee, C. Chen,
A. Motsinger-Reif, H. Sagreiya, N. Liu, A.H.B. Wu, B.F. Gage, A. Jorgensen, M.
Pirmohamed, J. Shin, G. Suarez-Kurtz, S.E. Kimmel, J.A. Johnson, T.E. Klein and M.J.
Wagner (2010) Warfarin Pharmacogenetics: A single VKORC1 polymorphism is
predictive of dose across three racial groups. Blood Vol. 115, No. 18: 3827-3834. PMCID:
PMC2865873.
27.
B. Zhang, D. Zhi, K. Zhang, G. Gao, N.A. Limdi, N. Liu* (2011) Practical Consideration
of Genotype Imputation: Sample Size, Window Size, Reference Choice, and Untyped
Rate. Statistics and Its Interface Vol. 4, No. 3: 339-352. PMCID: PMC3269888.
28.
W. Lin, B. Zhang, N. Yi, G. Gao, N. Liu* (2011) Evaluation of pooled association tests for
rare variant identification. BMC Proceedings 2011, 5(Suppl 9):S118. PMCID:
PMC3287842.
29.
W. Chen, X. Gao, J. Wang, C. Sun, W. Wan, D. Zhi, N. Liu, X. Chen, G. Gao (2011)
Evaluation of association tests for rare variants using simulated data sets in the Genetic
Analysis Workshop 17 data. BMC Proceedings 2011, 5(Suppl 9):S86. PMCID:
PMC3287927.
30.
N. Liu, H. Zhao, A. Patki, N.A. Limdi, D.B. Allison (2011) Controlling Population
Structure in Human Genetic Association Studies with Samples of Unrelated Individuals.
Statistics and Its Interface Vol. 4, No. 3: 317-326. PMCID: PMC3269890.
31.
J. Arcaroli, N. Liu, N. Yi, E. Abraham (2011) Association between IL-32 genotypes and
outcome in infection-associated acute lung injury. Critical Care, 15: R138. PMCID:
PMC3219007.
32.
N. Yi, N. Liu, D. Zhi, J. Li (2011) Hierarchical generalized linear models for multiple
groups of rare and common variants: jointly estimating group and individual-variant
effects. PLoS Genet 7(12): e1002382. PMCID: PMC3228815.
33.
D. Zhi, J. Wu, N. Liu, K. Zhang (2012) Genotype Calling from Next Generation
Sequencing Data using Haplotype Information of Reads. Bioinformatics 28(7): 938-946.
PMCID: PMC3493122.
34.
G. Gao, G. Kang, J. Wang, W. Chen, H. Qin, B. Jiang, Q. Li, C. Sun, N. Liu, K.J. Archer,
D.B. Allison (2012) A Generalized Sequential Bonferroni Procedure Using Smoothed
Weights for Genome-Wide Association Studies Incorporating Information on HardyWeinberg Disequilibrium among Cases. Hum Hered. 73:1-13. PMCID: PMC3268348.
35.
W. Lin, H.K. Tiwari, G. Gao, K. Zhang, J.J. Arcaroli, E. Abraham, N. Liu* (2012)
Similarity-based multi-marker association tests for continuous traits. Annals of Human
Genetics 76(3):246-260. PMCID: PMC3329946.
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Nianjun Liu
Curriculum Vitae
36.
W. Lin, N. Yi, D. Zhi, K. Zhang, G. Gao, H.K. Tiwari, N. Liu* (2012) Haplotype-based
methods for detecting uncommon causal variants with common SNPs. Genetic
Epidemiology 36:572-582. PMCID: PMC3513398.
37.
W. Lin, N. Liu* (2012) Reducing Bias of Allele Frequency Estimates by Modeling SNP
Genotype Data with Informative Missingness. Front. Gene. 3:107. doi:
10.3389/fgene.2012.00107. PMCID: PMC3376470.
38.
S. Wang, W. Chen, X. Chen, F. Hu, K. Archer, N. Liu, S. Sun and G. Gao (2012). Double
genomic control is not effective to correct for population stratification in Meta-analysis for
genome-wide association studies. Front. Gene. 3:300. doi: 10.3389/fgene.2012.00300.
PMCID: PMC3529452.
39.
W. Lin, O. Dubuisson, R. Rubicz, N. Liu, D.B. Allison, J.E. Curran, A.G. Comuzzie, J.
Blangero, C.T. Leach, H. Göring, and N.V. Dhurandhar (2013). Long term changes in
adiposity and glycemic control are associated with past adenovirus infection. Diabetes
Care 36:701-707. PMCID: PMC3579356.
40.
M.A. Perera, L.H. Cavallari, N.A. Limdi, E.R. Gamazon, A. Konkashbaev, R. Daneshjou,
A. Pluzhnikov, D.C. Crawford, J. Wang, N. Liu et al. (2013) Genetic variants associated
with warfarin dose in African-American individuals: a genome-wide association study.
Lancet 382(9894):790-6. PMCID: PMC3759580.
41.
W. Chen, X. Chen, K.J. Archer, N. Liu, Q. Li, Z. Zhao, S. Sun, G. Gao (2013) A rapid
association test procedure robust under different genetic models accounting for population
stratification. Human Heredity 75:23-33. PMCID: PMC3786013.
42.
W. Lin, N. Yi, X. Lou, D. Zhi, K. Zhang, G. Gao, H.K. Tiwari, N. Liu* (2013) Haplotype
Kernel Association Test as a Powerful Method to Identify Chromosomal Regions
Harboring Uncommon Causal Variants. Genetic Epidemiology 37(6):560-70. PMCID:
PMC4116485.
43.
P. Li, H. Tiwari, W. Lin, D.B. Allison, W. Chung, R. Leibel, N. Yi, and N. Liu* (2014)
Genetic Association Analysis of 30 Genes Related to Obesity in European American
Population. International Journal of Obesity 38(5):724-9. PMCID: PMC3909018.
44.
G. Chen, N. Liu, Y.C. Klimentidis, X. Zhu, D. Zhi, X. Wang, X. Lou (2014) A unified
GMDR method for detecting gene-gene interactions in family and unrelated samples with
application to nicotine dependence. Human Genetics 133(2):139-150. PMCID:
PMC3947150.
45.
W. Lin*, XY. Lou, G. Gao, N. Liu* (2014) Rare Variant Association Testing by Adaptive
Combination of P-values. PLoS ONE, 9: e85728. PMCID: PMC3893264.
46.
Q. Yan, H. K. Tiwari,N. Yi, W. Lin, G. Gao, X. Lou, X. Cui, and N. Liu* (2014) KernelMachine Testing Coupled with a Rank-Truncation Method for Genetic Pathway Analysis.
Genetic Epidemiology 38(5): 447-456. PMCID: PMC4073214.
47.
J. Wu, G-B Chen, D. Zhi, N. Liu, K. Zhang (2014) A hidden Markov model for haplotype
inference for present-absent data of clustered genes using identified haplotypes and
haplotype patterns. Front. Genet. 5:267. PMCID: PMC4129397.
48.
H-M Xu, X-W Sun, T. Qi, W. Lin, N. Liu, XY. Lou (2014) Multivariate dimensionality
reduction approaches to identify gene-gene and gene-environment interactions underlying
multiple complex traits. PLoS ONE 9(9): e108103. PMCID: PMC4178067.
Page 8/16
Nianjun Liu
Curriculum Vitae
49.
N. Liu, E. Archer, V. Srinivasasainagendra, DB Allison (2015) A Statistical Framework
for Testing the Causal Effects of Fetal Drive. Front. Genet. 5:464. doi:
10.3389/fgene.2014.00464. PMCID: PMC4292723.
50.
Q. Yan, H. K. Tiwari, N. Yi, G. Gao, K. Zhang, W. Lin, XY. Lou, N. Liu* (2015) A
Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a
Generalized Linear Mixed Model. Human Heredity 79(2):60-68. PMCID: Publisher
provided directly to PMC.
51.
D. Zhi, N. Liu, K. Zhang (2015) On the design and analysis of next-generation sequencing
genotyping for a cohort with haplotype-informative reads. Methods 79-80:41-6. PMCID:
PMC4437872.
52.
N. A. Limdi, T. M. Brown, Q. Yan, J. L. Thigpen, A. Shendre, N. Liu, C. E. Hill, D. K.
Arnett, and T. M. Beasley (2015) Race influences warfarin dose changes associated with
genetic factors. Blood (In press).
53.
W. Chen, C. Ren, H. Qin, K. J. Archer, W. Ouyang, N. Liu, X. Chen, X. Luo, X. Zhu, S.
Sun, and G. Gao (2015) A Generalized Sequential Bonferroni Procedure for GWAS in
Admixed Populations Incorporating Admixture Mapping Information into Association
Tests. Human Heredity (In press).
54.
H. Akhter, C. Ballinger, T. van Groen, N. Liu, E. M. Postlethwait, and R. Liu (2015)
Cyclic ozone exposure accelerates memory decline and induces gender-dependent
neuropathology in an animal model of Alzheimer’s disease. Toxicological Sciences (In
press).
Non-Peer Reviewed
1.
N. Liu* (2015) QTL mapping – Current status and challenges: Comment on “Mapping
complex traits as a dynamic system” by L. Sun and R. Wu. Physics of Life Reviews,
http://dx.doi.org/10.1016/j.plrev.2015.04.002.
Book Chapters
1.
B.R. Korf and N. Liu (2012). Human Genome Project, Genomics, and Clinical Research.
In “Principles and Practice of Clinical Research (Third edition)” (J. I. Gallin and F.P.
Ognibene, eds.), pp. 707-725. Academic Press.
2.
Z. Feng, N. Liu, and H. Zhao (2007). Haplotype inference and association analysis in
unrelated samples. In “Current Topics in Human Genetics: Studies in Complex Diseases”
(H. W. Deng, H. Shen, Y. J. Liu, and H. Hu, eds.), pp. 135–176. World Scientific
Publishing Company, Singapore.
Published Conference Abstracts
1.
G. Sanacora, R. Berman, A. Cappeillo, D. Oren, N. Liu, D. Charney. Addition of the 2antagonist Yohimbine to Fluoxetine: Effects on Rate of Antidepressant Response. The
Society of Biological Psychiatry 57th Annual Meeting, Philadelphia PA, May 16-18, 2002.
2.
J.H. Krystal, W. Abi-Saab, E. Perry, C. D’Souza, N. Liu, L. McDougall, A. Belger, L.
Levine, A. Breier. Modulation of Ketamine-induced Working Memory Deficits in Healthy
Human Subjects by the Group II Metabotropic Agonist, LY354740. The American College
of Neuropsychopharmacolgy 41st Annual Meeting, San Juan, Puerto Rico, December 8-12,
2002.
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Nianjun Liu
Curriculum Vitae
3.
G. Sanacora, R. Berman, A. Cappeillo, D. Oren, N. Liu, D. Charney. The 2-antagonist
Yohimbine Hastens Antidepressant Response to Fluoxetine. The American College of
Neuropsychopharmacolgy 41st Annual Meeting, San Juan, Puerto Rico, December 8-12,
2002.
4.
N. Liu, H. Zhao. A Nonparametric Approach for Population Structure Inference Using
Multilocus Genotypes. The American Society of Human Genetics 54th Annual Meeting,
Toronto, Ontario, Canada, October 26-30, 2004.
5.
J.H. Krystal, E. Perry, W. Abi-Saab, C. D’Souza, N. Liu, R. Gueorguieva, L. McDougall,
T. Hunsberger, A. Belger, L. Levine, A. Breier. Preliminary Evidence of Attenuation of the
Disruptive Effects of the NMDA Glutamate Receptor Antagonist, Ketamine, on Working
Memory by Pretreatment with the Group II Metabotropic Glutamate Receptor (mGluR)
Agonist, LY354740, in Healthy Human Subjects. The International Congress on
Schizophrenia Research, Savannah, Georgia, April 2-6, 2005.
6.
N. Liu, H. Zhao. Haplotype Analysis in the Presence of Missing Data. International
Genetic Epidemiology Society 14th Annual Meeting, Park City, Utah, October 23-24, 2005
7.
S. Gu, N. Liu, H. Zhao, K.K. Kidd. The Efficiency and Transferability of tagSNPs in Six
Populations from Three tagSNP Selection Algorithms. The American Society of Human
Genetics 55th Annual Meeting, Salt Lake City, Utah, October 25-29, 2005.
8.
N. Liu, I. Beerman, R. Lifton, H. Zhao. Haplotype Analysis in the Presence of Missing
Data. The American Society of Human Genetics 55th Annual Meeting, Salt Lake City,
Utah, October 25-29, 2005.
9.
N. Liu. Using Disease Information in TagSNP selection for Disease Association Mapping.
The American Society of Human Genetics 56th Annual Meeting, New Orleans, October 913, 2006.
10.
N. Liu, D. Zhang, H. Zhao. Genotyping error detection in unrelated samples. The
American Society of Human Genetics 57th Annual Meeting, San Diego, October 23-27,
2007.
11.
N. Liu. Modeling SNP genotype data with informative missingness in samples of unrelated
individuals. The American Society of Human Genetics 58th Annual Meeting, Philadelphia,
November 12-15, 2008.
12.
N. Liu, H. Zhao, D.B. Allison. Evaluation of Mixed-Model Approaches for Control of
Population Structure in Human Genetic Association Studies. The American Society of
Human Genetics 59th Annual Meeting, Honolulu, October 20-24, 2009.
13.
D. Zhi and N. Liu. Bayesian network model for SNP calling in shallow sequencing with
haplotype based prior. The American Society of Human Genetics 59th Annual Meeting,
Honolulu, October 20-24, 2009.
14.
W. Chen, X. Gao, J. Wang, C. Sun, W. Wan, D. Zhi, N. Liu, X. Chen, G. Gao. An
Evaluation of Association Tests for Rare Variants by Using Simulated datasets in the
GAW17 Data. Genetic Analysis Workshop 17, Boston, MA, October 13-16, 2010.
15.
W. Lin, B. Zhang, N. Yi, G. Gao, N. Liu. Evaluation of Pooled Association Tests for Rare
Variants Identification. Genetic Analysis Workshop 17, Boston, MA, October 13-16, 2010.
16.
B. Zhang, D. Zhi, K. Zhang, G. Gao, N.A. Limdi, N. Liu. Practical Consideration of
Genotype Imputation: Sample Size, Window Size, Reference Choice, and Untyped Rate.
Page 10/16
Nianjun Liu
Curriculum Vitae
The American Society of Human Genetics 60th Annual Meeting, Washington DC,
November 2-6, 2010.
17.
N. Liu. Statistical Methods for Rare Variants Identification. IMS-China, Xi’an, China, July
8-11, 2011.
18.
J. Wu, G. Chen, D. Zhi, N. Liu, and K. Zhang. A Hidden Markov Model for Haplotype
Inference Using Previously Identified Haplotype and Haplotype Patterns. ENAR 2011,
Miami, FL, March 20-23, 2011.
19.
W. Lin and N. Liu. Statistical Methods for Rare Variants Identification. ENAR 2011,
Miami, FL, March 20-23, 2011.
20.
N. Liu and B. Zhang. Differential call rates in genotype imputation and their effect on
genetic association studies. The 12th International Congress of Human Genetics and the
American Society of Human Genetics 61st Annual Meeting, Montreal, Canada, October
11-15, 2011.
21.
M. A. Perera, N. Limdi, L. Cavallari, E. R.Gamazon, A. Konkashbaev, A. Pluzhnikov J.
Wang, N. Liu, M. Wagner, A. Wu, D. Roden, D. Crawford, J. Eversten, B. Gage, T.
Mushiroda, M. Kubo, R. B. Altman, T. E. Klein, M. J. Rieder, Y. N., N. J. Cox, J. A.
Johnson. Novel SNPs Associated with Warfarin Dose in a Large Multicenter Cohort of
African Americans: Genome Wide Association Study and Replication Results. AHA/ASA,
Orlando, FL, November 13-15, 2011.
22.
N. V. Dhurandhar, W. Lin, O. Dubuisson, N. Liu, D. B. Allison, H. Goring. Infection with
a human adenovirus Ad36, is associated with longitudinal changes in adiposity and
glycemic control in men and women. 2012 Obesity Society Annual Scientific Meeting, San
Antonio, Texas, September 20-24, 2012.
23.
X. Lou. G. Chen, L. Yan, N. Liu, Y.C. Klimentidis, X. Zhu, D. Zhi, X. Wang. A PCAbased Generalized Multifactor Reduction Method for Correcting Population Stratification.
2012 Annual Meeting of the International Genetic Epidemiology Society, Stevenson,
Washington. October 18-20, 2012.
24.
J.L. Thigpen, Q. Yan, N. Liu, M. Beasley, N.A. Limdi. Racial differences in
anticoagulation control and risk of hemorrhage among warfarin users. Pharmacotherapy
2012; 32(10):e189.
25.
X. Lou, G. Chen, N. Liu, Y. Klimentidis, X. Zhu, D. Zhi, X. Wang. A unified generalized
multifactor reduction method for detecting gene-gene interactions in family and unrelated
samples with application to nicotine dependence. The American Society of Human
Genetics Annual Meeting, San Francisco, November 6-10, 2012.
26.
N. Liu, W. Lin, N. Yi, D. Zhi, K. Zhang, G. Gao, H. Tiwari. Haplotype-based methods for
detecting uncommon causal variants with common SNPs. The American Society of Human
Genetics Annual Meeting, San Francisco, November 6-10, 2012.
27.
N. Liu. Haplotype-based methods for detecting uncommon causal variants with
common SNPs in genetic association studies. IMS-China International Conference on
Statistics and Probability, Chengdu, China, June 30 - July 4, 2013.
28.
N. Liu, Q. Yan, N. Yi. A Powerful Statistical Method for Genetic Pathway Analysis. The
American Society of Human Genetics Annual Meeting, Boston, October 22-26, 2013.
Page 11/16
Nianjun Liu
29.
Curriculum Vitae
M.I. Danila, R. Reynolds, Q. Yan, N. Liu, P. K. Gregersen, D. K. Arnett, S. L. Bridges Jr.
High-Density Genotyping of Risk Loci in African Americans with RA. Arthritis &
Rheumatology 2014; 66: S1069-S1070.
Oral Presentations
Conference Oral Presentations
1.
N. Liu, S.L. Sawyer, N. Mukherjee, A.J. Pakstis, J.R. Kidd, K.K. Kidd, A.J. Brookes, H.
Zhao. Measures of Similarity for Haplotype Block Structures Show Variation among
Populations. The American Society of Human Genetics 53rd Annual Meeting, Los Angeles,
California, USA, November 4-8, 2003.
2.
N. Liu, S.L. Sawyer, N. Mukherjee, A.J. Pakstis, J.R. Kidd, K.K. Kidd, A.J. Brookes, H.
Zhao. Similarity Measures for Haplotype Block Structures Show Variation Among 16
Populations. The International HapMap Community Analysis Meeting, Baltimore, MD,
USA, April 18-20, 2004. (Invited)
3.
N. Liu, D. Zhang, H. Zhao. Genotyping Error Detection in Samples of Unrelated
Individuals. International Biometric Society ENAR Annual Meeting, Arlington, VA, USA,
March 16-19, 2008.
4.
N. Liu, I. Beerman, R. Lifton, R. Bucala, H. Zhao. Haplotype Analysis in the Presence of
Informatively Missing Genotype Data. 1st NHGRI-funded Conference: Haplotype Analysis
of Population & Pedigree Data in Association Studies. Birmingham, AL, USA, May 7 - 8,
2008. (Invited)
5.
N. Liu. Modeling SNP Genotype Data with Informative Missingness in Samples of
Unrelated Individuals. International Biometric Society ENAR Annual Meeting, San
Antonio, Texas, USA, March 15-18, 2009.
6.
N. Liu. Modeling Informatively Missing Genotypes in Haplotype Analysis. Joint
Conference of the Society for Mathematical Biology and the Chinese Society for
Mathematical Biology, Hangzhou, P. R. China, June 14-17, 2009. (Invited)
7.
N. Liu, H. Zhao, A. Patki, N.A. Limdi, D.B. Allison. Evaluation of Mixed-Model for
Control of Population Stratification in Human Genetic Studies. First Joint Biostatistics
Symposium, Beijing, China, July 17-18, 2010. (Invited)
8.
N. Liu, H. Zhao, A. Patki, N.A. Limdi, D.B. Allison. Evaluation of Mixed-Model for
Control of Population Stratification in Human Genetic Studies. Joint Statistical Meetings,
Vancouver, Canada, July 31 - August 5, 2010.
9.
N. Liu, W. Lin, N. Yi, D. Zhi, K. Zhang, G. Gao, and H. K. Tiwari . Haplotype-based
methods for detecting uncommon causal variants with common SNPs in genetic
association studies. IMS-China International Conference on Statistics and Probability,
Chengdu, China, June 30 - July 4, 2013.
10.
Q. Yan, N. Liu. Kernel machine testing coupled with rank truncation method for genetic
pathway analysis. Joint Statistical Meetings, Montreal, Canada, August 3 - August 8, 2013.
11.
Q. Yan, B. Li, W. Chen, N. Liu. Kernel Machine Regression for Multivariate Quantitative
Phenotypes in Family Samples. The American Society of Human Genetics Annual
Meeting, San Diego, CA, October 18–22, 2014.
Page 12/16
Nianjun Liu
Curriculum Vitae
Invited Seminar Talks
Dec. 9, 2004
Computational Biology and Bioinformatics Track, Yale University
Mar. 4, 2005
Department of Mathematics and Statistics, Georgia State University
Mar. 24, 2005
Center for Human Genetics Research, Vanderbilt University
Mar. 28, 2005
Department of Biostatistics, School of Public Health, University of Alabama at
Birmingham
Apr. 8, 2005
Department of Biostatistics, The Johns Hopkins University
Apr. 15, 2005
Department of Biostatistics and Applied Mathematics, University of Texas M.D.
Anderson Cancer Center
Apr. 22, 2005
ROWE Program in Human Genetics, University of California, Davis
Jan. 27, 2009
Cardiovascular Research Institute, Morehouse School of Medicine
Jun. 20, 2013
Institute of Systems Science, Chinese Academy of Sciences
Service Activities
Editorships
•
•
•
•
•
•
Associate Editor for Frontiers in Statistical Genetics and Methodology, 2010 – present
Associate Editor for Frontiers in Nutrition Methodology, 2014 – present
Editor for Biometrics & Biostatistics International Journal, 2014 – present
Editorial Board Member for The Open Access Journal of Science and Technology, 2013 –
present
Editorial Board Member for Austin Statistics, 2014 – present
Editorial Board Member for Enliven: Biostatistics and Metrics, 2014 – present
Journal Reviewing
Reviewed more than 100 manuscripts for the following journals:
• The American Journal of Human Genetics
• The American Journal of Clinical Nutrition
• Annals of Human Genetics
• Bioinformatics
• Biometrics
• Biostatistics
• BMC Bioinformatics
• BMC Genetics
• BMC Medical Genomics
• Cancer Epidemiology Biomarkers & Prevention
• Computational Statistics and Data Analysis
• Genetic Epidemiology
• Genetics
• Genome Research
• Heredity
• Human Heredity
• Human Genetics
Page 13/16
Nianjun Liu
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Curriculum Vitae
Human Molecular Genetics
JAMA
Journal of Clinical Endocrinology and Metabolism
Journal of Computational Biology
Journal of Genetics and Genomics
Molecular Psychiatry
The Open Access Journal of Science and Technology
PLoS Computational Biology
PLoS Genetics
PLoS ONE
PNAS
Scientific Reports
Statistics in Biosciences
Statistica Sinica
Conference Reviewing
•
•
•
•
•
BIOINFORMATICS 2012 (International Conference on Bioinformatics Models, Methods
and Algorithms, BIOSTEC 2012 - 5th International Joint Conference on Biomedical
Engineering Systems and Technologies)
The Tenth Asia-Pacific Bioinformatics Conference (APBC2012)
The 3rd International Conference on BioMedical Engineering and Informatics (BMEI'10),
2010
The 59th Annual Meeting of the American Society of Human Genetics, 2009
Computational Systems and Bioinformatics Conference (CSB), 2006
Conference Organizing
•
Member, Program Committee, The 3rd International Congress on Image and Signal
Processing (CISP'10) The 3rd International Conference on BioMedical Engineering and
Informatics (BMEI'10), Yantai, China, October 16-18, 2010
Grant Reviewing
o 2015
• NIH study section 2015/06 IMST-D(55)
• NIH study section 2015/05 ZMH1 ERB-S (02) R
o 2014
• Italian Ministry of Health
• NIH study section 2014/10 ZMH1 ERB-D (09) S - BSNIP2
• The Association of Schools of Public Health (ASPH)/Centers for Disease Control and
Prevention (CDC) Public Health Fellowship Program Application Review Committee
• The Nutrition Obesity Research Center (NORC), University of Alabama at
Birmingham
o 2013
• NIH study section ZMH1 ERB-D 02 S BSNIP-2
• Italian Ministry of Health
• NIH study section ZDE1 JR 17 1
• The Association of Schools of Public Health (ASPH)/Centers for Disease Control and
Prevention (CDC) Public Health Fellowship Program Application Review Committee
Page 14/16
Nianjun Liu
Curriculum Vitae
o 2012
• NIH IRAP study section
• The Association of Schools of Public Health (ASPH)/Centers for Disease Control and
Prevention (CDC) Public Health Fellowship Program Application Review Committee
• University of Wisconsin-Milwaukee
o 2011
• NIH study section ZRG1 HDM-R (11)
• The Association of Schools of Public Health (ASPH)/Centers for Disease Control and
Prevention (CDC) Alan Rosenfield Global Health Fellowship Program Application
Review Committee
• NORC and UWIRC, University of Alabama at Birmingham
• KPRI at Children’s Hospital, University of Alabama at Birmingham
o 2010
• Italian Ministry of Health
• Recovery Act Limited Competition: NIH Director’s Opportunity for Research in Five
Thematic Areas (RC4)
• The Association of Schools of Public Health (ASPH)/Centers for Disease Control and
Prevention (CDC) Alan Rosenfield Global Health Fellowship Program Application
Review Committee
o 2009
• The Association of Schools of Public Health (ASPH)/Centers for Disease Control and
Prevention (CDC) Alan Rosenfield Global Health Fellowship Program Application
Review Committee
• Special Emphasis Panel reviewer for National Institutes of Health (2010/01 ZRG1
PSE-A (02) M)
• National Institutes of Health Challenge Grants (ZRG1 PSE-C (58))
• National Institutes of Health Challenge Grants (ZRG1 PSE-J (58))
o 2008
• The Israel Science Foundation
o 2007
• The Association of Schools of Public Health (ASPH)/Centers for Disease Control and
Prevention (CDC)/Prevention Research Centers (PRC) Minority Fellowship Program
Application Review Committee
Working Committee
• Member, China Information Technology Standardization Technical Committee, 1995 –
1997
• Member, China Universal Multiple-Octet Coded Character Set Working Group, 1995 –
1997
Other Selected Service Activities
• Chair, Graduate Program Committee, Department of Biostatistics, UAB, Apr. 2015 –
present
• Alternate member, School of Public Health Educational Policy Committee, UAB, Sep.
2012 – present
• Alternate member, School of Public Health Admission and Graduation Committee, UAB,
July 2013 – present
Page 15/16
Nianjun Liu
Curriculum Vitae
• Member, Graduate Program Committee, Department of Biostatistics, UAB, Jan. 2013 –
March 2015
• Chair, Admission Committee, Department of Biostatistics, UAB, Jan. 2013 – Mar. 2015
• Member, Diversity Council, UAB, Sep. 1, 2011 – May 31, 2013
• Member, Faculty Search Committee, Department of Biostatistics, UAB, June 2012 – Oct.
2012
• Member, School of Public Health Educational Policy Committee, UAB, Sep. 2011 – Aug.
2012
• Vice Chair and Chair, School of Public Health Educational Policy Committee, UAB, Sep.
2009 – Aug. 2010, and Sep. 2010 – Aug. 2011, respectively
• Member, School of Public Health Internship Committee, UAB, Oct. 2009 – Aug. 2012
• Member, Program Committee of BIOINFORMATICS 2012 (International Conference on
Bioinformatics Models, Methods and Algorithms, BIOSTEC 2012 - 5th International Joint
Conference on Biomedical Engineering Systems and Technologies), Stockholm, Sweden,
June 2012
• Alternate Senator, University Faculty Senate, UAB, June 2009 – May 2011
• Member, Admission Committee, Department of Biostatistics, UAB, Dec. 2010 – Dec.
2012
• Member, Postdoctoral Search Committee, Section on Statistical Genetics, Department of
Biostatistics, UAB, April 2008 – April 2010
• School of Public Health Representative on the University-wide Faculty Affairs Committee,
UAB, June 2007 – May 2013
• Senator, University Faculty Senate, UAB, June 2007 –May 2009, May 2011 – May 2013
• Organizer and Chair, Session on Statistical Genetics and Genomics, First Joint Biostatistics
Symposium, Beijing, P. R. China, July 2010
• Organizer and Chair, Mini-Symposium on Statistical Genetics, Joint Conference of the
Society for Mathematical Biology and the Chinese Society for Mathematical Biology,
Hangzhou, P. R. China, June 15, 2009
• Moderator of Session on Statistical Genomics, the American Society of Human Genetics
59th Annual Meeting, Honolulu, Hawaii, Oct. 22, 2009
• Moderator of Session on Haplotype-based Association Methods, 1st NHGRI – funded
Conference: Haplotype Analysis of Population & Pedigree Data in Association Studies,
Birmingham, AL, May 8, 2008
• Maintain an archive of data from real studies for SSG at UAB, July 2006 – present
• Judge, UAB Postdoctoral Research Day, 2006, 2009
• Judge, UAB Graduate Student Research Day, February 2010
• Grader, UAB Department of Epidemiology comprehensive exams, 2010 – 2013
• Grader, UAB Department of Biostatistics comprehensive exams, 2006 – 2011, 2013-2015
Page 16/16