Comments
Description
Transcript
FRUSCIO Robert
CURRICULUM VITAE Informazioni personali Nome e Cognome Data di nascita Qualifica Amministrazione Incarico attuale Numero telefonico ufficio Indirizzo e-mail istituzionale Robert Fruscio 16/12/1976 Dirigente Medico Ospedale San Gerardo Ginecologia Chirurgica/Ginecologia Oncologica 0392339434 [email protected] Titoli di studio e professionali ed esperienze lavorative Titolo di studio 1995: Diploma di Scuola Superiore (Liceo Classico) 2001: Laurea in Medicina e Chirurgia presso l’Universita’ degli Studi di Milano-Bicocca con il punteggio di 110/110 e lode Specializzazione 2006: Diploma di Specializzazione in Ostetricia e Ginecologia 2010: Dottore di ricerca in Ginecologia Oncologica Esperienze Giu ’99 - Lug ‘01: Tesista, Laboratorio di Farmacologia professionali Antitumorale, Dipartimento di Oncologia, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italia (incarichi ricoperti) Lug ’01 - oggi: Research fellow, Laboratorio di Farmacologia Antitumorale, Dipartimento di Oncologia, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italia Oct ‘01 – Oct ‘06: Iscritto alla Scuola di Specializzazione in Ostetricia e Ginecologia, l’Universita’ degli Studi di MilanoBicocca, Ospedale San Gerardo, Monza Mar ’04 – Mar ’05: Research fellow, Laboratorio di Farmacologia Antitumorale, Departimento di Medicina, Massachusetts General Hospital, Harvard University (Boston, MA, USA) Nov ’06 – Feb ‘10: Iscritto al Dottorato di Ricerca in Ginecologia Oncologica presso l’Università degli Studi di Milano-Bicocca da Gen ’07 - oggi: Assunto in qualita’ di dirigente medico presso la Clinica Ostetrica e Ginecologica, Ospedale San Gerardo, Monza da Ott '10 - oggi: Professore a contratto della Scuola di Specialità in Ginecologia e Ostetricia dell'Università degli Studi di Milano-Bicocca da Ott ‘11 - oggi: Professore a contratto del Corso di Laurea di Ostetricia dell'Università degli Studi di Milano-Bicocca Capacità linguistiche Capacità nell’uso delle tecnologie Italiano parlato e scritto (madrelingua) Inglese parlato e scritto: livello ottimo Ottime capacità nell'uso di tecnologie per la diagnostica ultrasonografica in ambito ginecologico Buone capacità della tecnologia informatica Altro (partecipazione a convegni e seminari, pubblicazioni, collaborazioni a riviste, ecc., ed ogni altra informazione che il dirigente ritiene di dover pubblicare) ALTRI INCARICHI Da luglio 2002 a luglio 2006 direttore esecutivo del Journal of Medicine and the Person Membro dell’ advisory board della rivista internazionale, peer reviewed “Advances in Therapy” Membro dell’ advisory board della rivista internazionale, peer reviewed “Journal of Chinese Clinical Medicine” Da gennaio 2010 Editore Associato della rivista internazionale, peer reviewed “BioMed Central Cancer” Peer-reviewer for diverse riviste internazionali, tra le quali: Advances in Therapy Archives of Gynecology and Obstetrics British Journal of Cancer Cancer Investigation Cancer Chemotherapy and Pharmacology Cancer Epidemiology, Biomarkers and Prevention Cancer Genetics and Cytogenetics Cancer Therapy European Journal of Cancer European Journal of Obstetrics & Gynecology Reproductive Biology Gynecologic Oncology Gynecological Surgery International Journal of Gynecology and Obstetrics Journal of Ecology and the Natural Environment Oncology Pediatric Drugs Surgical Endoscopy and Co-investigatore nello studio clinico multicentrico randomizzato a doppio cieco di fase 2 con AVE0005 in pazienti affette da tumore ovarico (ARD6122, sponsorizzato da Sanofi-Aventis). Co-investigatore nello studio multicentrico randomizzato di fase 3 con Pazopanib in pazienti con tumore ovarico dopo prima linea chemioterapica (AGO/OVAR16, VEG110655 sponsorizzato da GlaxoSmithKline) Co-investigatore nello studio clinico multicentrico randomizzato a doppio cieco di fase 3 con BIBF 1120 in combinazione con carboplatino e paclitaxel in pazienti con carcinoma ovarico avanzato (AGO/OVAR12, BI 1199.15, sponsorizzato da Boehringer Ingelheim) Co-investigatore nello studio clinico multicentrico di fase 3 con Bevacizumab in pazienti con carcinoma ovarico (ROSiA study, MO22923 sponsorizzato da F. Hoffmann-La Roche Ltd.). Principal Investigator negli studi clinico multicentrici IOTA2, IOTA3, IOTA5, IETA. Membro della Società Europea di Ginecologia Oncologica (ESGO) Membro della taskforce dell'ESGO sui tumori in gravidanza (http://www.cancerinpregnancy.org/node/29) Pubblicazioni scientifiche 1. Sottani C, Colombo T, Zucchetti M, Fruscio R, D'Incalci M, Minoia C. High-performance liquid chromatography/ tandem mass spectrometry for the quantitative analysis of a novel taxane derivative (BAY59-8862) in biological samples and characterization of its metabolic profile in rat bile samples Rapid Commun Mass Spectrom 2001; 15: 1807-1816 2. D’Incalci M, Erba E, Damia G, Galliera E, Carcassa L, Marchini S, Tognon G, Fruscio R, Jimeno J Faircloth GT Unique features of the mode of action of ET-743 Oncologist. 2002;7(3):210-6 3. M. Zaffaroni, R. Frapolli, T. Colombo, R. Fruscio, E. Bombardelli, P. Morazzoni, A. Riva, M. D’Incalci and M. Zucchetti High-performance liquid chromatographic assay for the determination of the novel C-Seco-taxane derivative (IDN 5390) in mouse plasma Journal of Chromatography B, 780 (2002) 93-98 4. Lissoni AA, Fei F, Rossi R, Fruscio R, Villa A, Zani G Ifosfamide in the treatment of malignant epithelial ovarian tumors Oncology. 2003;65 Suppl 2:59-62 5. Polato F, Codegoni A, Fruscio R, Perego P, Mangioni C, Saha S, Bardelli A, Broggini M PRL-3 phosphatase is implicated in ovarian cancer growth Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6835-9 6. Fruscio R, Lissoni AA, Frapolli R, Corso S, Mangioni C, D'Incalci M, Zucchetti M Clindamycin-paclitaxel pharmacokinetic interaction in ovarian cancer patients Cancer Chemother Pharmacol. 2006 Sep;58(3):319-25 7. Assi F, Fruscio R, Bonardi C, Ghidini A, Allavena P, Mantovani A, Locatelli A Pentraxin 3 in plasma and vaginal fluid in women with preterm delivery BJOG, 2007 Feb;114(2):143-7 8. Vecchione F, Fruscio R, Dell’Anna T, Garbi A, Garcia Parra R, Corso S, Lissoni A A Phase II clinical trial of Topotecan and Carboplatin in patients with newly diagnosed advanced epithelial ovarian cancer International Journal of Gynecological Cancer, 2007 Mar-Apr;17(2):367-72 9. Marchini S, Marabese M, Marrazzo E, Mariani P, Cattaneo D, Fossati R, Compagnoni A, Fruscio R, Lissoni AA, Broggini M ∆Np63 expression is associated with poor survival in ovarian cancer Ann Oncol. 2008 Mar;19(3):501-7 10. Fruscio R, Colombo N, Lissoni AA, Garbi A, Fossati R, Ieda' N, Torri V, Mangioni C A phase II randomised clinical trial comparing cisplatin, paclitaxel and ifosfamide with cisplatin, paclitaxel and epirubicin in newly diagnosed advanced epithelial ovarian cancer: long-term survival analysis Br J Cancer. 2008 Feb 26;98(4):720-7 11. Signorelli M, Fruscio R, Lissoni AA, Pirovano C, Perego P, Mangioni C Synchronous early-stage endometrial and ovarian cancer Int J Gynaecol Obstet. 2008 Jul;102(1):34-8 12. Pellegrino A, Fruscio R, Maneo A, Corso S, Battistello M, Chiappa V, Stomati M. Harmonic scalpel versus conventional electrosurgery in the treatment of vulvar cancer Int J Gynaecol Obstet. 2008 Nov;103(2):185-8 13. Fruscio R, Padula F, Mancini E, Pellegrino A, De Nictolis M. Malignant transformation of vaginal endometriosis treated with neoadjuvant chemotherapy and surgery J Obstet Gynaecol Res. 2008 Aug;34(4 Pt 2):706-8 14. Pellegrino A, Villa A, Fruscio R, Signorelli M, Meroni MG, Iedà N, Vitobello D. Total laparoscopic radical hysterectomy and pelvic lymphadenectomy in early stage cervical cancer Surg Laparosc Endosc Percutan Tech. 2008 Oct;18(5):474-8 15. Marchini S, Mariani P, Chiorino G, Marrazzo E, Bonomi R, Fruscio R, Clivio L, Garbi A, Torri V, Cinquini M, Dell'Anna T, Apolone G, Broggini M, D'Incalci M. Analysis of gene expression in early-stage ovarian cancer Clin Cancer Res. 2008 Dec 1;14(23):7850-60 16. Pellegrino A, Vizza E, Fruscio R, Villa A, Corrado G, Villa M, Dell'anna T, Vitobello D. Total laparoscopic radical hysterectomy and pelvic lymphadenectomy in patients with Ib1 stage cervical cancer: Analysis of surgical and oncological outcome Eur J Surg Oncol. 2009 Jan;35(1):98103 17. Pellegrino A, Signorelli M, Fruscio R, Villa A, Buda A, Beretta P, Garbi A, Vitobello D. Feasibility and morbidity of total laparoscopic radical hysterectomy with or without pelvic limphadenectomy in obese women with stage I endometrial cancer Arch Gynecol Obstet. 2008 Sep 16 18. Kieran MW, Supko JG, Wallace D, Fruscio R, Poussaint TY, Phillips P, Pollack I, Packer R, Boyett JM, Blaney S, Banerjee A, Geyer R, Friedman H, Goldman S, Kun LE, Macdonald T; on behalf of the Pediatric Brain Tumor Consortium. Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors Pediatr Blood Cancer. 2009 Feb;52(2):169176 19. Lissoni AA, Colombo N, Pellegrino A, Parma G, Zola P, Katsaros D, Chiari S, Buda A, Landoni F, Peiretti M, Dell'anna T, Fruscio R, Signorelli M, Grassi R, Floriani I, Fossati R, Torri V, Rulli E. A phase II, randomized trial of neo-adjuvant chemotherapy comparing a three-drug combination of paclitaxel, ifosfamide, and cisplatin (TIP) versus paclitaxel and cisplatin (TP) followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the Snap-02 Italian Collaborative Study Ann Oncol. 2009 Apr;20(4):660-5 20. Signorelli M, Chiappa V, Minig L, Fruscio R, Perego P, Caspani G, Battistello M, Colombo N. Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. Int J Gynecol Cancer. 2009 Aug;19(6):1142-6 21. Trio C, Recalcati D, Sina F, Fruscio R. Intrauterine fallopian tube incarceration after vacuum aspiration for pregnancy termination Int J Gynaecol Obstet. 2010 Feb;108(2):157-8 22. Timmerman D, Van Calster B, Testa AC, Guerriero S, Fischerova D, Lissoni AA, Van Holsbeke C, Fruscio R, Czekierdowski A, Jurkovic D, Savelli L, Vergote I, Bourne T, Van Huffel S, Valentin L. Ovarian cancer prediction in adnexal masses using ultrasound-based logistic regression models: a temporal and external validation study by the IOTA group Ultrasound Obstet Gynecol. 2010 Aug;36(2):22634 23. Daemen A, Valentin L, Fruscio R, Van Holsbeke C, Melis GB, Guerriero S, Czekierdowski A, Jurkovic D, Ombelet W, Rossi A, Vergote I, Bourne T, De Moor B, Timmerman D. Improving the preoperative classification of adnexal masses as benign or malignant by second stage tests Ultrasound Obstet Gynecol. 2011 Jan;37(1):100-6 24. Daemen A, Jurkovic D, Van Holsbeke C, Guerriero S, Testa AC, Czekierdowski A, Fruscio R, Paladini D, Neven P, Rossi A, Bourne T, De Moor B, Timmerman D. The effect of cancer prevalence on the use of different cut-off levels and the performance of mathematical models to distinguish benign from malignant adnexal masses Ultrasound Obstet Gynecol. 2011 Feb;37(2):226-31 25. Signorelli M, Fruscio R, Dell'Anna T, Buda A, Giuliani D, Ceppi L, Milani R. Lymphadenectomy in uterine low-grade endometrial stromal sarcoma: an analysis of 19 cases and a literature review Int J Gynecol Cancer. 2010 Nov;20(8):1363-6 26. Timmerman D, Ameye L, Fischerova D, Epstein E, Melis GB, Guerriero S, Van Holsbeke C, Savelli L, Fruscio R, Lissoni AA, Testa AC, Veldman J, Vergote I, Van Huffel S, Bourne T, Valentin L. Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group BMJ. 2010 Dec 14;341 27. Vizza E, Pellegrino A, Milani R, Fruscio R, Baiocco E, Cognetti F, Savarese A, Tomao F, Chen C, Corrado G. Total laparoscopic radical hysterectomy and pelvic lymphadenectomy in locally advanced stage IB2-IIB cervical cancer patients after neoadjuvant chemotherapy Eur J Surg Oncol. 2011 Apr;37(4):364-9 28. Ganzinelli M, Mariani P, Cattaneo D, Fossati R, Fruscio R, Corso S, Ricci F, Broggini M, Damia G. Expression of DNA repair genes in ovarian cancer samples: Biological and clinical considerations Eur J Cancer. 2011 May;47(7):108694 29. Fruscio R, Garbi A, Parma G, Lissoni AA, Garavaglia D, Bonazzi CM, Dell'anna T, Mangioni C, Milani R, Colombo N. Randomized phase III clinical trial evaluating weekly cisplatin for advanced epithelial ovarian cancer J Natl Cancer Inst. 2011 Feb 16;103(4):347-51 30. Marchini S, Cavalieri D, Fruscio R, Calura E, Garavaglia D, Nerini IF, Mangioni C, Cattoretti G, Clivio L, Beltrame L, Katsaros D, Scarampi L, Menato G, Perego P, Chiorino G, Buda A, Romualdi C, D'Incalci M. Association between miR200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections Lancet Oncol. 2011 Mar;12(3):273-85 31. Valentin L, Ameye L, Savelli L, Fruscio R, Leone F, Czekierdowski A, Lissoni A, Fischerova D, Guerriero S, Van Holsbeke C, Van Huffel S, Timmerman D. Adnexal masses difficult to classify as benign or malignant using subjective assessment of gray scale and Doppler ultrasound findings: logistic regression models do not help Ultrasound Obstet Gynecol. 2011 Oct;38(4):456-65 32. Signorelli M, Guerra L, Montanelli L, Crivellaro C, Buda A, Dell'anna T, Picchio M, Milani R, Fruscio R, Messa C. Preoperative staging of cervical cancer: Is 18-FDG-PET/CT really effective in patients with early stage disease? Gynecol Oncol. 2011 Nov;123(2):236-40 33. Van Holsbeke CD, Van Calster B, Bourne T, Ajossa S, Testa AC, Guerriero S, Fruscio R, Lissoni AA, Czekierdowski A, Savelli L, Van Huffel S, Valentin L, Timmerman D. External validation of diagnostic models to estimate the risk of malignancy in adnexal masses Clin Cancer Res. 2012 Feb 1;18(3):815-25. Epub 2011 Nov 23 34. Silini A, Ghilardi C, Figini S, Sangalli F, Fruscio R, Dahse R, Pedley RB, Giavazzi R, Bani M. Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor's proangiogenic microenvironment Cell Mol Life Sci. 2012 Apr;69(7):1167-78. Epub 2011 Dec 1. 35. Caiola E, Porcu L, Fruscio R, Giuliani D, Milani R, Torri V, Broggini M, Marabese M. DNA-damage response gene polymorphisms and therapeutic outcomes in ovarian cancer Pharmacogenomics J. 2011 Dec 13. 36. Mosig RA, Lobl M, Senturk E, Shah H, Cohen S, Chudin E, Fruscio R, Marchini S, D'Incalci M, Sachidanandam R, Dottino P, Martignetti JA. IGFBP-4 tumor and serum levels are increased across all stages of epithelial ovarian cancer. J Ovarian Res. 2012 Jan 20;5(1):3 37. Mosig RA, Lin L, Senturk E, Shah H, Huang F, Schlosshauer P, Cohen S, Fruscio R, Marchini S, D'Incalci M, Sachidanandam R, Dottino P, Martignetti JA. Application of RNA-Seq transcriptome analysis: CD151 is an Invasion/Migration target in all stages of epithelial ovarian cancer. J Ovarian Res. 2012 Jan 24;5:4 38. Buda A, Fruscio R, Pirovano C, Signorelli M, Betti M, Milani R. The use of TachoSil for the prevention of postoperative complications after groin dissection in cases of gynecologic malignancy. Int J Gynaecol Obstet. 2012 Jun;117(3):217-9 39. Buda A, Confalonieri PL, Rovati LC, Fruscio R, Giuliani D, Signorelli M, Dell'anna T, Pirovano C, Milani R. Better Anatomical and Cosmetic Results Using Tunneled Lotus Petal Flap for Plastic Reconstruction After Demolitive Surgery for Vulvar Malignancy. Int J Gynecol Cancer. 2012 Jun;22(5):860-4 40. Fadini R, Dal Canto M, Mignini Renzini M, Milani R, Fruscio R, Cantù MG, Brambillasca F, Coticchio G. Embryo transfer following in vitro maturation and cryopreservation of oocytes recovered from antral follicles during conservative surgery for ovarian cancer. J Assist Reprod Genet. 2012 Aug;29(8):779-81 41. Ricci F, Bernasconi S, Perego P, Ganzinelli M, Russo G, Bono F, Mangioni C, Fruscio R, Signorelli M, Broggini M, Damia G. Ovarian carcinoma tumor-initiating cells have a mesenchymal phenotype. Cell Cycle. 2012 May 15;11(10). 42. Fruscio R, Villa A, Chiari S, Vergani P, Ceppi L, Dell'Orto F, Dell'Anna T, Chiappa V, Bonazzi CM, Milani R, Mangioni C, Locatelli A. Delivery delay with neoadjuvant chemotherapy for cervical cancer patients during pregnancy: a series of nine cases and literature review. Gynecol Oncol. 2012 Aug;126(2):192-7 43. Caiola E, Rulli E, Fruscio R, Buda A, Broggini M, Marabese M. KRas-LCS6 polymorphism does not impact on outcomes in ovarian cancer. Am J Cancer Res. 2012;2(3):298-308 44. Marchini S, Poynor E, Barakat RR, Clivio L, Cinquini M, Fruscio R, Porcu L, Bussani C, D'Incalci M, Erba E, Romano M, Cattoretti G, Katsaros D, Koff A, Luzzatto L. The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer. Clin Cancer Res. 2012 Aug 15;18(16):4313-24 45. Fruscio R, Mangioni C, Milani R. Reply to: Are the outcomes of neoadjuvant chemotherapy for stage Ib2 cervical cancer similar in pregnant and nonpregnant patients? Gynecol Oncol. 2012 Oct;127(1):258-9 46. Crivellaro C, Signorelli M, Guerra L, De Ponti E, Buda A, Dolci C, Pirovano C, Todde S, Fruscio R, Messa C. 18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer. Gynecol Oncol. 2012 Oct;127(1):131-5 47. Franchi D, Boveri S, Fruscio R, Fischerova D, Guerriero S, Moruzzi M, Colombo N, Timmerman D, Valentin L, Testa AC. Imaging in gynecological disease (8): ultrasound characteristics of ovarian borderline tumor recurrence. Ultrasound Obstet Gynecol. 2012 Aug 1. doi: 10.1002/uog.12276. [Epub ahead of print] 48. Dell' Anna T, Signorelli M, Benedetti-Panici P, Maggioni A, Fossati R, Fruscio R, Milani R, Bocciolone L, Buda A, Mangioni C, Scambia G, Angioli R, Campagnutta E, Grassi R, Landoni F. Systematic lymphadenectomy in ovarian cancer at second-look surgery: a randomised clinical trial. Br J Cancer. 2012 Aug 21;107(5):785-92 49. Marchini S, Fruscio R, Clivio L, Beltrame L, Porcu L, Nerini IF, Cavalieri D, Chiorino G, Cattoretti G, Mangioni C, Milani R, Torri V, Romualdi C, Zambelli A, Romano M, Signorelli M, Giandomenico SD, D'Incalci M. Resistance to platinumbased chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer. Eur J Cancer. 2012 Aug 13. [Epub ahead of print] 50. Valentin L, Ameye L, Savelli L, Fruscio R, Leone F, Czekierdowski A, Lissoni A, Fischerova D, Guerriero S, Van Holsbeke C, Van Huffel S, Timmerman D. Unilocular adnexal cysts with papillary projections but no other solid components: is there a diagnostic method that can reliably classify them as benign or malignant before surgery? Ultrasound Obstet Gynecol. 2012 Aug 23. doi: 10.1002/uog.12294. [Epub ahead of print] 51. Fruscio R, Corso S, Ceppi L, Garavaglia D, Garbi A, Floriani I, Franchi D, Cantù MG, Bonazzi CM, Milani R, Mangioni C, Colombo N. Conservative management of early-stage epithelial ovarian cancer: results of a large retrospective series. Ann Oncol. 2012 Sep 3. [Epub ahead of print] 52. Valentin L, Ameye L, Franchi D, Guerriero S, Jurkovic D, Savelli L, Fischerova D, Lissoni A, Van Holsbeke C, Fruscio R, Van Huffel S, Testa A, Timmerman D. The risk of malignancy in unilocular cysts: a study on 1148 adnexal masses classified as unilocular cysts at transvaginal scan with review of the literature. Ultrasound Obstet Gynecol. 2012 Sep 24. doi: 10.1002/uog.12308. [Epub ahead of print] Relazioni a congressi • Dermoid ovarian cysts: diagnostic value of sonography 13th World Congress on Ultrasound in Obstetrics and Gynecology, Parigi, Settembre 2003 • Fattibilità e laparoscopica morbosità dell’istrectomia radicale (con linfoadenctomia pelvica) nel carcinoma dell’endometrio e nel sarcoma dell’utero 82mo Congresso della Societa’ Italiana di Ginecologia ed Ostetricia (SIGO), Roma, Ottobre 2006 • Total radical laparoscopic hysterectomy and pelvic lymphadenectomy in early-stage cervical cancer: analysis of feasibility and oncologic outcome - Advances in Gynaecological Oncology, 19° Congresso Nazionale SIOG, Milano, Giugno 2007 • Terapia laparoscopica conservativa nel carcinoma dell’ovaio - Stato dell’arte dell’endoscopia in oncologia ginecologica, San Giovanni Rotondo, 27 – 28 Sttembre 2007 • La neoplasia della vulva: protocolli terapeutici chirurgici e nuove tecniche – IX Congresso Nazionale SIGiTE, Mesagne (Brindisi), 18 – 21 Giugno 2008 • Bersagli molecolari nella terapia del carcinoma ovarico IX Congresso Nazionale SIGiTE, Mesagne (Brindisi), 18 – 21 Giugno 2008 • Long-term results from a randomized phase III clinical trial evaluating weekly cisplatin administration in newly diagnosed epithelial advanced ovarian cancer – ESGO Congress, Belgrade (Serbia), October 11 – 14, 2009