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Chemical Directory of NTP Studies 04/13/2016 3,3',4,4'-Tetrachloroazobenzene

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Chemical Directory of NTP Studies 04/13/2016 3,3',4,4'-Tetrachloroazobenzene
Chemical Directory of NTP Studies 04/13/2016
3,3',4,4'-Tetrachloroazobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
GAVAGE
88486-97
R88486B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprag Daw (CD)
10/14/2009
TI
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg PND21 F1
02 - 0.1mg/k PND21 F1
03 - 1.0mg/k PND21 F1
04 - 0mg/kg PND21 F1
05 - 0.1mg/k PND21 F1
06 - 1.0mg/k PND21 F1
07 - 10mg/k PND 21 F1
08 - 0mg/kg NBT1 F1
09 - 0.1mg/kg NBT1 F1
10 - 1.0mg/kg NBT1 F1
11 - 0mg/kg NBT2 F1
12 - 0.1mg/kg NBT2 F1
13 - 1.0mg/kg NBT2 F1
14 - 10mg/kg ETerm F1
15 - 10 PND22-26UDF1
16 - 0.1 PND42 UD F1
17 - 10mg/kg ETerm F1
18 - .1 PND22-26 U F1
19 - 10 PND22-26 U F1
20 - 0.1 PND72 UD F1
21 - 10mg/kg PND21 F1
V
T
T
V
T
T
T
V
T
T
V
T
T
T
T
T
T
T
T
T
T
F
F
F
M
M
M
M
M
M
M
M
M
M
F
F
F
M
M
M
M
F
CORN OIL : ACETONE (99 : 1)
Page 1
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
7-week
GAVAGE
88486-98
R88486B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprag Daw (CD)
09/18/2009
TI
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg PND4 F0
02 - 0mg/kg PND21 F0
03 - 0.1mg/kg PND4 F0
04 - 0.1mg/kgPND21 F0
05 - 1mg/kg PND4 F0
06 - 1mg/kg PND21 F0
07 - 10mg/kg PND4 F0
08 - 10mg/kg PND21 F0
09 - 0.1mg/kg UnschF1
10 - 0.1mg/kg UnschF1
11 - 1.0mg/kg UnschF1
12 - 1.0mg/kg UnschF1
13 - 10mg/kg UnschF1
14 - 10mg/kg UnschF1
V
V
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
M
F
M
F
M
F
CORN OIL : ACETONE (99 : 1)
Page 2
Abrasive Blasting Agents: Blasting Sand
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20213-01
C20213
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
10/10/2005
BN
BLASTINGSAND
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 3 mg/m3
03 - 15 mg/m3
04 - 30 mg/m3
V
T
T
T
M
M
M
M
AIR
Page 3
Abrasive Blasting Agents: Blasting Sand (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
RESP BDY
20213-02
C20213
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
04/20/2009
BN
BLASTINGSAND
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - 15 mg/m3
03 - 30 mg/m3
04 - 60 mg/m3
V
T
T
T
M
M
M
M
AIR
Page 4
Abrasive blasting agents (coal slag)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20532-01
C20532
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/05/2005
BN
COALSLAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 3 mg/m3
03 - 15 mg/m3
04 - 30 mg/m3
V
T
T
T
M
M
M
M
AIR
Page 5
Abrasive blasting agents (crushed glass)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20534-01
C20534
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
06/12/2006
BN
CRUSHEDGLASS
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - vehicle control
02 - 3 mg/m3
03 - 15 mg/m3
04 - 30 mg/m3
V
T
T
T
M
M
M
M
AIR
Page 6
Abrasive blasting agents (garnet)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20533-01
C20533
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/27/2006
BN
GARNET
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 3 mg/m3
03 - 15 mg/m3
04 - 30 mg/m3
V
T
T
T
M
M
M
M
AIR
Page 7
Abrasive Blasting Agents: Specular Hematite
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20536-01
C20536
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
08/14/2006
BN
HEMATITESPEC
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 3 mg/m3
03 - 15 mg/m3
04 - 30 mg/m3
05 - 60 mg/m3
V
T
T
T
T
M
M
M
M
M
AIR
Page 8
Abrasive Blasting Agents: Specular Hematite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
RESP BDY
20536-02
C20536
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/27/2009
BN
HEMATITESPEC
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - 15 mg/m3
03 - 30 mg/m3
04 - 60 mg/m3
V
T
T
T
M
M
M
M
AIR
Page 9
Acetaminophen (4-hydroxyacetanilide)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05035-02
C55801
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/28/1982
MA
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL UM
02 - 0.06% LM
03 - 0.3% MM
04 - 0.6% HM
05 - CONTROL UF
06 - 0.06% LF
07 - 0.3% MF
08 - 0.6% HF
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 10
Acetaminophen (4-hydroxyacetanilide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05035-03
C55801
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/29/1982
MA
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL UM
02 - 0.06% LM
03 - 0.3% MM
04 - 0.6% HM
05 - CONTROL UF
06 - 0.06% LF
07 - 0.3% MF
08 - 0.6% HF
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 11
Acetaminophen (4-hydroxyacetanilide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20325-01
C20325
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/09/2003
IL
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 150 MG/KG
03 - 1500 MG/KG
04 - 2500 MG/KG
V
T
T
T
M
M
M
M
0.5% Ethylcellulose
Page 12
Acetaminophen (4-hydroxyacetanilide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20539-01
C20539
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/24/2005
IL
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg 3hrs
02 - 150 mg/kg 3hrs
03 - 1500 mg/kg 3hrs
04 - 2000 mg/kg 3hrs
05 - 0 mg/kg 6hrs
06 - 150 mg/kg 6hrs
07 - 1500 mg/kg 6hrs
08 - 2000 mg/kg 6hrs
09 - 0 mg/kg 24hrs
10 - 150 mg/kg 24hrs
11 - 1500 mg/kg 24hrs
12 - 2000 mg/kg 24hrs
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
0.5% Ethylcellulose
Page 13
Acetaminophen (4-hydroxyacetanilide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
55801-04
C55801C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/16/2001
IL
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CTL 50 6HR
02 - 50 MG/KG 6HR
03 - CTL 50 24/48HR
04 - 50 MG/KG 24HR
05 - 50 MG/KG 48HR
06 - CTL 150 6HR
07 - 150MG/KG 6HR
08 - CTL 150 24HR
09 - 150MG/KG 24HR
10 - CTL 150 48HR
11 - 150MG/KG 48HR
12 - CTL 1500 6HR
13 - 1500MGKG 6HR
14 - CTL 1500 24HR
15 - 1500MGKG24HR
16 - CTL 1500 48HR
17 - 1500MGKG48HR
18 - CTL 2000 6HR
19 - 2000MGKG 6HR
20 - CTL 2000 24HR
21 - 2000MGKG 24HR
22 - CTL 2000 48HR
23 - 2000MGKG 48HR
U
T
U
T
T
U
T
U
T
U
T
U
T
U
T
U
T
U
T
U
T
U
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5% Ethylcellulose
Page 14
Acetaminophen (4-hydroxyacetanilide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
55801-06
C55801E
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/16/2002
BC
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6 HR
02 - 0 MG/KG 18 HR
03 - 0 MG/KG 24 HR
04 - 0 MG/KG 48 HR
05 - 50 MG/KG6 HR
06 - 50 MG/KG18 HR
07 - 50 MG/KG24 HR
08 - 50 MG/KG48 HR
09 - 150MG/KG6 HR
10 - 150MG/KG18 HR
11 - 150MG/KG24 HR
12 - 150MG/KG48 HR
13 - 1500MG/K6 HR
14 - 1500MG/K18 HR
15 - 1500MG/K24 HR
16 - 1500MG/K48 HR
17 - 2000MG/K6 HR
18 - 2000MG/K18 HR
19 - 2000MG/K24 HR
20 - 2000MG/K48 HR
21 - 0 MG/KG SPECIAL
22 - 50 MG/KGSPECIAL
23 - 1500MG/KSPECIAL
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 15
Acetaminophen (4-hydroxyacetanilide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
55801-07
C55801E
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/16/2002
BC
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6 HR-N
02 - 0 MG/KG 18 HR-N
03 - 0 MG/KG 24 HR-N
04 - 0 MG/KG 48 HR-N
05 - 50 MG/KG6 HR-N
06 - 50 MG/KG18 HR-N
07 - 50 MG/KG24 HR-N
08 - 50 MG/KG48 HR-N
09 - 150MG/KG6HR-N
10 - 150MG/KG18 HR-N
11 - 150MG/KG24 HR-N
12 - 150MG/KG48 HR-N
13 - 1500MG/K6 HR-N
14 - 1500MG/K18 HR-N
15 - 1500MG/K24 HR-N
16 - 1500MG/K48 HR-N
17 - 2000MG/K6 HR-N
18 - 2000MG/K18 HR-N
19 - 2000MG/K24 HR-N
20 - 2000MG/K48 HR-N
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 16
Acetaminophen (4-hydroxyacetanilide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
55801-08
C55801C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/31/2002
IL
103-90-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 15MG/KG CTL/6HR
02 - 15MG/KG 6HR
03 - 50MG/KG CTL/6HR
04 - 50MG/KG 6HR
05 - 50MG/KG CTL/24HR
06 - 50MG/KG 24HR
07 - 50MG/KG CTL/48HR
08 - 50MG/KG 48HR
09 - 150MG/KG CTL/6HR
10 - 150MG/KG 6HR
11 - 150MG/KGCTL/24HR
12 - 150MG/KG 24HR
13 - 150MG/KGCTL/48HR
14 - 150MG/KG 48HR
15 - 1500MG/K CTL/6HR
16 - 1500MG/K 6HR
17 - 1500MG/KCTL/24HR
18 - 1500MG/K 24HR
19 - 1500MG/KCTL/48HR
20 - 1500MG/K 48HR
21 - 2000MG/KCTL/6HR
22 - 2000MG/K 6HR
23 - 2000MG/KCTL/24HR
24 - 2000MG/K 24HR
25 - 2000MG/KCTL/48HR
26 - 2000MG/K 48HR
V
T
V
T
V
T
V
T
V
T
V
T
V
T
V
T
V
T
V
T
V
T
V
T
V
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5% Ethylcellulose
Page 17
Acetoin
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20724-01
C20724
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
10/27/2008
BN
513-86-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 6.25 PPM
04 - 6.25 PPM
05 - 25 PPM
06 - 25 PPM
07 - 100 PPM
08 - 100 PPM
09 - 400 PPM
10 - 400 PPM
11 - 800 PPM
12 - 800 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 18
Acetoin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20724-02
C20724
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/27/2008
BN
513-86-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 6.25 PPM
04 - 6.25 PPM
05 - 25 PPM
06 - 25 PPM
07 - 100 PPM
08 - 100 PPM
09 - 400 PPM
10 - 400 PPM
11 - 800 PPM
12 - 800 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 19
Acetoin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20724-03
C20724
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
06/29/2009
BN
513-86-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 50 ppm
04 - 50 ppm
05 - 100 ppm
06 - 100 ppm
07 - 200 ppm
08 - 200 ppm
09 - 400 ppm
10 - 400 ppm
11 - 800 ppm
12 - 800 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 20
Acetoin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20724-04
C20724
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/29/2009
BN
513-86-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 50 ppm
04 - 50 ppm
05 - 100 ppm
06 - 100 ppm
07 - 200 ppm
08 - 200 ppm
09 - 400 ppm
10 - 400 ppm
11 - 800 ppm
12 - 800 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 21
Acetone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05173-01
C00022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/18/1986
MB
67-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 %
02 - 0 %
03 - 0.25 %
04 - 0.25 %
05 - 0.5 %
06 - 0.5 %
07 - 1 %
08 - 1 %
09 - 2 %
10 - 2 %
11 - 5 %
12 - 5 %
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 22
Acetone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05173-02
C00022
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/21/1986
MB
67-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 %
02 - 0 %
03 - 0.125 %
04 - 0.25 %
05 - 0.25 %
06 - 0.5 %
07 - 0.5 %
08 - 1 %
09 - 1 %
10 - 2 %
11 - 2 %
12 - 5 %
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
M
F
M
F
M
F
M
F
F
TAP WATER
Page 23
Acetonitrile
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05133-01
C60822B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/08/1986
BN
75-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
09 - 800 PPM
10 - 800 PPM
11 - 1600 PPM
12 - 1600 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 24
Acetonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05133-02
C60822B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/10/1986
BN
75-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
09 - 800 PPM
10 - 800 PPM
11 - 1600 PPM
12 - 1600 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 25
Acetonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05133-03
C60822B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/31/1988
BN
75-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 26
Acetonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05133-04
C60822B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/07/1988
BN
75-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 50 PPM
04 - 50 PPM
05 - 100 PPM
06 - 100 PPM
07 - 200 PPM
08 - 200 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 27
Acrolein
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
02802-01
C02802C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/20/1995
BC
107-02-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.25 MG/KG
06 - 1.25 MG/KG
07 - 2.5 MG/KG
08 - 2.5 MG/KG
09 - 5 MG/KG
10 - 5 MG/KG
11 - 10 MG/KG
12 - 10 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 28
Acrolein (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
02802-02
C02802C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/16/1995
BC
107-02-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.25 MG/KG
04 - 1.25 MG/KG
05 - 2.5 MG/KG
06 - 2.5 MG/KG
07 - 5 MG/KG
08 - 5 MG/KG
09 - 10 MG/KG
10 - 10 MG/KG
11 - 20 MG/KG
12 - 20 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 29
Acrolein (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
02802-03
C02802C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/20/1995
BC
107-02-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.25 MG/KG
06 - 1.25 MG/KG
07 - 2.5 MG/KG
08 - 2.5 MG/KG
09 - 5 MG/KG
10 - 5 MG/KG
11 - 10 MG/KG
12 - 10 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 30
Acrylamide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20313-01
C20313
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
07/12/2004
NR
79-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 10 UG/ML
03 - 25 UG/ML
04 - 50 UG/ML
05 - 100 UG/ML
06 - 250 UG/ML
07 - CONTROL
08 - 10 UG/ML
09 - 25 UG/ML
10 - 50 UG/ML
11 - 100 UG/ML
12 - 250 UG/ML
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
UNTREATED
WATER
Page 31
UNTREATED
WATER
Acrylamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20313-02
C20313
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
07/12/2004
NR
79-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - 10 ug/ml
03 - 25 ug/ml
04 - 50 ug/ml
05 - 100 ug/ml
06 - 250 ug/ml
07 - Control
08 - 10 ug/ml
09 - 25 ug/ml
10 - 50 ug/ml
11 - 100 ug/ml
12 - 250 ug/ml
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
WATER
Page 32
Acrylamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20313-03
C20313B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
08/09/2004
NR
79-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
25 - Control Feed M
26 - 7.4 PPM Acryl M
27 - 18.5 PPM Acryl M
28 - 37 PPM Acryl M
29 - 74 PPM Acryl M
30 - 185 PPM Acryl M
31 - Control Feed F
32 - 7.4 PPM Acryl F
33 - 18.5 PPM Acryl F
34 - 37 PPM Acryl F
35 - 74 PPM Acryl F
36 - 185 PPM Acryl F
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-31 (Irradiated)
Page 33
Acrylamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20313-04
C20313B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
08/02/2004
NR
79-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
25 - Control Feed M
26 - 18.5 PPM Acryl M
27 - 37 PPM Acryl M
28 - 74 PPM AcryL M
29 - 185 PPM Acryl M
30 - 370 PPM Acryl M
31 - Control Feed F
32 - 18.5 PPM Acryl F
33 - 37 PPM Acryl F
34 - 74 PPM Acryl F
35 - 185 PPM Acryl F
36 - 370 PPM Acryl F
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-31 (Irradiated)
Page 34
Acrylamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20313-05
C20313
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
05/30/2005
NR
79-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.70 ACRYL
02 - 0.35 ACRYL
03 - 0.175 ACRYL
04 - 0.0875 ACRYL
05 - CONTROL WATER
06 - 0.70 ACRYL
07 - 0.35 ACRYL
08 - 0.175 ACRYL
09 - 0.0875 ACRYL
10 - CONTROL WATER
T
T
T
T
V
T
T
T
T
V
M
M
M
M
M
F
F
F
F
F
FILTERED WATER
Page 35
Acrylamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20313-06
C20313
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
06/02/2005
NR
79-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.70 ACRYL
02 - 0.35 ACRYL
03 - 0.175 ACRYL
04 - 0.0875 ACRYL
05 - CONTROL WATER
06 - 0.70 ACRYL
07 - 0.35 ACRYL
08 - 0.175 ACRYL
09 - 0.0875 ACRYL
10 - CONTROL WATER
T
T
T
T
V
T
T
T
T
V
M
M
M
M
M
F
F
F
F
F
FILTERED WATER
Page 36
Acrylonitrile
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
50215-01
C50215B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/21/1995
BC
107-13-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 5 MG/KG
04 - 5 MG/KG
05 - 10 MG/KG
06 - 10 MG/KG
07 - 20 MG/KG
08 - 20 MG/KG
09 - 40 MG/KG
10 - 40 MG/KG
11 - 60 MG/KG
12 - 60 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 37
Acrylonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
50215-03
C50215B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/03/1997
BC
107-13-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 2.5 MG/KG
04 - 2.5 MG/KG
05 - 10 MG/KG
06 - 10 MG/KG
07 - 20 MG/KG
08 - 20 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 38
Adeno-associated viral vector (hEPO)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
INT CANN
20305-01
C20305
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
02/02/2004
MB
AAVIRVECEPO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - ISORMCONSALINE
02 - TRTRMCONSALINE
03 - 1-7 SALINE
04 - 1-8 SALINE
05 - 1-9 SALINE
06 - 1-10 SALINE
07 - ISORMCONSALINE
08 - TRTRMCONSALINE
09 - 1-7 SALINE
10 - 1-8 SALINE
11 - 1-9 SALINE
12 - 1-10 SALINE
V
V
T
T
T
T
V
V
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
SALINE
Page 39
Adenoviral vector (hGH)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
INT CANN
20212-01
C20212
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/15/2002
MB
ADNVIRVECHGH
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE SALINE
02 - VEHICLE HCQ
03 - 6.0 E9 SALINE
04 - 1.5 E11 HCQ
05 - 6.0 E9 HCQ
06 - 2.4 E8 HCQ
V
V
T
T
T
T
M
M
M
M
M
M
SALINE
HCQ
SALINE
HCQ
Page 40
Adenoviral vector (hGH) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
INT CANN
20212-02
C20212
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/22/2002
MB
ADNVIRVECHGH
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE SALINE
02 - VEHICLE HCQ
03 - 6.0 E9 SALINE
04 - 1.5 E11 HCQ
05 - 6.0 E9 HCQ
06 - 2.4 E8 HCQ
V
V
T
T
T
T
F
F
F
F
F
F
SALINE
HCQ
SALINE
HCQ
Page 41
Adenoviral vector (hGH) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
OTHER
20212-85
C20212
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/23/2005
MB
ADNVIRVECHGH
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VehContrCohrtA
02 - VehContrCohrtB
03 - VehContrCohrtC
04 - VehContrCohrtD
05 - VehContrCohrtE
06 - 2-8AdhAQP1CohrA
07 - 2-8AdhAQP1CohrB
08 - 2-8AdhAQP1CohrC
09 - 2-8AdhAQP1CohrD
10 - 2-8AdhAQP1CohrE
11 - 8-9AdhAQP1CohrA
12 - 8-9AdhAQP1CohrB
13 - 8-9AdhAQP1CohrC
14 - 8-9AdhAQP1CohrD
15 - 8-9AdhAQP1CohrE
16 - 2-11AdhAQP1CohrA
17 - 2-11AdhAQP1CohrB
18 - 2-11AdhAQP1CohrC
19 - 2-11AdhAQP1CohrD
20 - 2-11AdhAQP1CohrE
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
10% Glycerol
Page 42
Adenoviral vector (hGH) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
OTHER
20212-86
C20212
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/23/2005
MB
ADNVIRVECHGH
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VehContrCohrtA
02 - VehContrCohrtB
03 - VehContrCohrtC
04 - VehContrCohrtD
05 - VehContrCohr E
06 - 2-8AdhAQP1CohtA
07 - 2-8AdhAQP1CohtB
08 - 2-8AdhAQP1CohtC
09 - 2-8AdhAQP1CohtD
10 - 2-8AdhAQP1CohtE
11 - 8-9AdhAQP1CohtA
12 - 8-9AdhAQP1CohtB
13 - 8-9AdhAQP1CohtC
14 - 8-9AdhAQP1CohtD
15 - 8-9AdhAQP1CohtE
16 - 2-11AdhAQP1CohtA
17 - 2-11AdhAQP1CohtB
18 - 2-11AdhAQP1CohtC
19 - 2-11AdhAQP1CohtD
20 - 2-11AdhAQP1CohtE
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
10% Glycerol
Page 43
Adenoviral Vector (AdhAQP1)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
20537-01
C20537
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/18/2005
MB
ADNVIRVECAQP
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHCONTRCOHRTA
02 - VEHCONTRCOHRTB
03 - VEHCONTRCOHRTC
04 - VEHCONTRCOHRTD
05 - VEHCONTRCOHR E
06 - 2-8ADHAQP1COHTA
07 - 2-8ADHAQP1COHTB
08 - 2-8ADHAQP1COHTC
09 - 2-8ADHAQP1COHTD
10 - 2-8ADHAQP1COHTE
11 - 8-9ADHAQP1COHTA
12 - 8-9ADHAQP1COHTB
13 - 8-9ADHAQP1COHTC
14 - 8-9ADHAQP1COHTD
15 - 8-9AJDAQP1COHTE
16 - 2-11ADHAQP1COHTA
17 - 2-11ADHAQP1COHTB
18 - 2-11ADHAQP1COHTC
19 - 2-11ADHAQP1COHTD
20 - 2-11ADHAQP1COHTE
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
10% Glycerol
Page 44
Adenoviral Vector (AdhAQP1) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
20537-02
C20537
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/25/2005
MB
ADNVIRVECAQP
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHCONTRCOHRTA
02 - VEHCONTRCOHRTB
03 - VEHCONTRCOHRTC
04 - VEHCONTRCOHRTD
05 - VEHCONTRCOHRTE
06 - 2-8ADHAQP1COHTA
07 - 2-8ADHAQP1COHTB
08 - 2-8ADHAQP1COHTC
09 - 2-8ADHAQP1COHTD
10 - 2-8ADHAQP1COHTE
11 - 8-9ADHAQP1COHTA
12 - 8-9ADHAQP1COHTB
13 - 8-9ADHAQP1COHTC
14 - 8-9ADHAQP1COHTD
15 - 8-9ADHAQP1COHTE
16 - 2-11ADHAQP1COHTA
17 - 2-11ADHAQP1COHTB
18 - 2-11ADHAQP1COHTC
19 - 2-11ADHAQP1COHTD
20 - 2-11ADHAQP1COHTE
21 - VEHCONTRCOHRTB
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
10% Glycerol
Page 45
Aging Cohort Study: 129/SvlmJ mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09045-01
C09045
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, 129S1/SvImJ
09/21/2009
BC
MOUSEPHENO1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 46
Aging Cohort Study: B6C3F1J mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09050-01
C09050
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1J
09/30/2009
BC
MOUSEPHENO6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 47
Aging Cohort Study: C3H/HeJ mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09047-01
C09047
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3H/HeJ
09/29/2009
BC
MOUSEPHENO3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 48
Aging Cohort Study: C57/BL/6J mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09048-01
C09048
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
09/18/2009
BC
MOUSEPHENO4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 49
Aging Cohort Study: CAST/EiJ mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09049-01
C09049
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, CAST/EiJ
08/04/2010
BC
MOUSEPHENO5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 50
Aging Cohort Study: NZO/HiLtJ mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09054-01
C09054
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, NZO/HiLtJ
01/12/2010
BC
MOUSEPHENO10
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 51
Aging Cohort Study: PWK/PhJ mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09052-01
C09052
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, PWK/PhJ
01/11/2010
BC
MOUSEPHENO8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 52
Aging Cohort Study: WSB/EIJ mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09053-01
C09053
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, WSB/EiJ
07/15/2010
BC
MOUSEPHENO9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 53
Aging Cohort Study: A/J mouse
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09046-01
C09046
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, A/J
09/17/2009
BC
MOUSEPHENO2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 54
Aging Cohort Study: NOD. B10Sn-H2(b)/J
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
NOT APPL
09051-01
C09051
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, NOD. B10Sn-H2(b)/J
07/16/2010
BC
MOUSEPHENO7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Male Mice
02 - Female Mice
U
U
M
F
NTP 2000 (IRRADIATED)
Page 55
Allergen (Airways Disease Project)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
IP/OT
20707-01
C20707
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, A/J
05/07/2007
BN
NDERP1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - allergen
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 56
Allergen (Airways Disease Project) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
IP/OT
20707-02
C20707
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, A/J
10/09/2007
BN
NDERP1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - allergen
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 57
Allergen (Airways Disease Project) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
IP/OT
20707-03
C20707
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
10/08/2007
BN
NDERP1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - allergen
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 58
Allyl acetate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93010-01
C93010
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/23/1995
BC
591-87-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6 MG/KG
04 - 6 MG/KG
05 - 12 MG/KG
06 - 12 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
09 - 50 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 100 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 59
Allyl acetate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93010-02
C93010
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/26/1995
BC
591-87-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 8 MG/KG
04 - 8 MG/KG
05 - 16 MG/KG
06 - 16 MG/KG
07 - 32 MG/KG
08 - 32 MG/KG
09 - 62.5 MG/KG
10 - 62.5 MG/KG
11 - 125 MG/KG
12 - 125 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 60
Allyl acetate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93010-03
C93010
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/23/1995
BC
591-87-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6 MG/KG
04 - 6 MG/KG
05 - 12 MG/KG
06 - 12 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
09 - 50 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 100 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 61
Allyl alcohol
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20327-01
C20327
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/01/2004
IL
107-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6HR
02 - 10 MG/KG6HR
03 - 20 MG/KG6HR
04 - 40 MG/KG6HR
05 - 50 MG/KG6HR
06 - 0 MG/KG 24 HR
07 - 10 MG/KG24HR
08 - 20 MG/KG24HR
09 - 40 MG/KG24HR
10 - 50 MG/KG24HR
11 - 0 MG/KG 48HR
12 - 10 MG/KG48HR
13 - 20 MG/KG48HR
14 - 40 MG/KG48HR
15 - 50 MG/KG48HR
16 - 0 MG/KG 72HR
17 - 10 MG/KG72HR
18 - 20 MG/KG72HR
19 - 40 MG/KG72HR
20 - 50 MG/KG72HR
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 62
Allyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93009-01
C93009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/20/1995
BC
107-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.5 MG/KG
04 - 1.5 MG/KG
05 - 3 MG/KG
06 - 3 MG/KG
07 - 6 MG/KG
08 - 6 MG/KG
09 - 12 MG/KG
10 - 12 MG/KG
11 - 25 MG/KG
12 - 25 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 63
Allyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93009-02
C93009
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/16/1995
BC
107-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 6 MG/KG
06 - 6 MG/KG
07 - 12 MG/KG
08 - 12 MG/KG
09 - 25 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 50 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 64
Allyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93009-03
C93009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/20/1995
BC
107-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.5 MG/KG
04 - 1.5 MG/KG
05 - 3 MG/KG
06 - 3 MG/KG
07 - 6 MG/KG
08 - 6 MG/KG
09 - 12 MG/KG
10 - 12 MG/KG
11 - 25 MG/KG
12 - 25 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 65
Allyl bromide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
96003-01
C96003B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
09/15/1998
MB
106-95-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 7.5 MG/KG
03 - 15 MG/KG
04 - 30 MG/KG
05 - 60 MG/KG
06 - 120 MG/KG
07 - VEHICLE CONTROL
08 - 7.5 MG/KG
09 - 15 MG/KG
10 - 30 MG/KG
11 - 60 MG/KG
12 - 120 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 66
Allyl bromide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96003-02
C96003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6
09/16/1998
MB
106-95-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 7.5 MG/KG
03 - 15 MG/KG
04 - 30 MG/KG
05 - 60 MG/KG
06 - 120 MG/KG
07 - VEHICLE CONTROL
08 - 7.5 MG/KG
09 - 15 MG/KG
10 - 30 MG/KG
11 - 60 MG/KG
12 - 120 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 67
Allyl bromide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
96003-03
C96003C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
03/22/1999
MB
106-95-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.5 MG/KG
03 - 1 MG/KG
04 - 2 MG/KG
05 - 4 MG/KG
06 - 8 MG/KG
07 - POSITIVECONTROL
08 - VEHICLE CONTROL
09 - 0.5 MG/KG
10 - 1 MG/KG
11 - 2 MG/KG
12 - 4 MG/KG
13 - 8 MG/KG
14 - POSITIVECONTROL
V
T
T
T
T
T
P
V
T
T
T
T
T
P
M
M
M
M
M
M
M
F
F
F
F
F
F
F
CORN OIL
Page 68
ACETONE
CORN OIL
ACETONE
Allyl bromide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
96003-04
C96003C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
03/22/1999
MB
106-95-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 8 MG/KG
03 - VEHICLE CONTROL
04 - 8 MG/KG
V
T
V
T
M
M
F
F
CORN OIL
Page 69
Allyl bromide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
96003-05
C96003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
04/01/1999
MB
106-95-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.5 MG/KG
03 - 1 MG/KG
04 - 2 MG/KG
05 - 4 MG/KG
06 - 8 MG/KG
07 - VEHICLE CONTROL
08 - 0.5 MG/KG
09 - 1 MG/KG
10 - 2 MG/KG
11 - 4 MG/KG
12 - 8 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 70
Allyl bromide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
96003-06
C96003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6
04/01/1999
MB
106-95-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 8 MG/KG
03 - VEHICLE CONTROL
04 - 8 MG/KG
V
T
V
T
M
M
F
F
CORN OIL
Page 71
Allyl glycidyl ether
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05080-01
C56666
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, OSBORNE-MEND
06/21/1982
BN
106-92-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 5 PPM MALE
04 - 5 PPM FEMALE
05 - 10 PPM MALE
06 - 10 PPM FEMALE
U
U
T
T
T
T
M
F
M
F
M
F
AIR
Page 72
Allyl glycidyl ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05080-02
C56666
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/21/1982
BN
106-92-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 5 PPM MALE
04 - 5 PPM FEMALE
05 - 10 PPM MALE
06 - 10 PPM FEMALE
U
U
T
T
T
T
M
F
M
F
M
F
AIR
Page 73
Aloe phototoxicity studies
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
SKIN
20406-01
C20406
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SKH-1/NCTR
05/11/2003
NR
ALOEPHOTOTOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
20 - NOCREAM NO_SSL
21 - VEHICLE NO_SSL
22 - ALOGEL6% NO_SSL
23 - WHLEAF6% NO_SSL
24 - CHARCL6% NO_SSL
25 - AEMOD_HI NO_SSL
26 - NOCREAM 6.85SSL
27 - NOCREAM 13.7SSL
28 - VEHICLE 13.7SSL
29 - ALOGEL3% 13.7SSL
30 - ALOGEL6% 13.7SSL
31 - WHLEAF3% 13.7SSL
32 - WHLEAF6% 13.7SSL
33 - CHARCL3% 13.7SSL
34 - CHARCL6% 13.7SSL
35 - AEMOD_LO 13.7SSL
36 - AEMOD_HI 13.7SSL
37 - NOCREAM 20.5SSL
U
V
T
T
T
T
T
T
V
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
NIH-31 (Irradiated)
Cosmetech Cream
Page 74
NIH-31 (Irradiated)
Cosmetech Cream
NIH-31 (Irradiated)
Aloe phototoxicity studies (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
SKIN
20406-02
C20406
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SKH-1/NCTR
05/11/2003
NR
ALOEPHOTOTOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NOCREAM NO_ SSL
02 - VEHICLE NO_SSL
03 - ALOGEL6% NO_ SSL
04 - WHLEAF6% NO_ SSL
05 - CHARCL6% NO_ SSL
06 - AEMOD_ H NO_ SSL
07 - NOCREAM 6.85SSL
08 - NOCREAM 13.7SSL
09 - VEHICLE 13.7SSL
10 - ALOGEL3% 13.7SSL
11 - ALOGEL6% 13.7SSL
12 - WHLEAF3% 13.7SSL
13 - WHLEAF6% 13.7SSL
14 - CHARL3% 13.7SSL
15 - CHARCL6% 13.7SSL
16 - AEMOD_LO 13.7SSL
17 - AEMOD_HI 13.7SSL
18 - NOCREAM 20.5SSL
U
V
T
T
T
T
T
T
V
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
NIH-31 (Irradiated)
Cosmetech Cream
Page 75
NIH-31 (Irradiated)
Cosmetech Cream
NIH-31 (Irradiated)
Aloe vera whole leaf extract (native)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20116-01
C20116B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/16/2003
NR
ALOEVLEAFEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 1% WLN
03 - 2% WLN
04 - 3% WLN
05 - CONTROL
06 - 1% WLN
07 - 2% WLN
08 - 3% WLN
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
FILTERED WATER
Page 76
Aloe vera whole leaf extract (native) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20116-02
C20116B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/09/2003
NR
ALOEVLEAFEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 1% WLN
03 - 2% WLN
04 - 3% WLN
05 - CONTROL
06 - 1% WLN
07 - 2% WLN
08 - 3% WLN
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
FILTERED WATER
Page 77
Aloe vera whole leaf extract (native) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20116-03
C20116B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
04/25/2005
NR
ALOEVLEAFEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL WATER
02 - ALOEWHOLLEAF 0.5
03 - ALOEWHOLLEAF 1.0
04 - ALOEWHOLLEAF 1.5
05 - CONTROL WATER
06 - ALOEWHOLLEAF 0.5
07 - ALOEWHOLLEAF 1.0
08 - ALOEWHOLLEAF 1.5
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
FILTERED WATER
Page 78
Aloe vera whole leaf extract (native) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20116-04
C20116B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
04/27/2005
NR
ALOEVLEAFEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL WATER
02 - ALOEWHOLLEAF 1.0
03 - ALOEWHOLLEAF 2.0
04 - ALOEWHOLLEAF 3.0
05 - CONTROL WATER
06 - ALOEWHOLLEAF 1.0
07 - ALOEWHOLLEAF 2.0
08 - ALOEWHOLLEAF 3.0
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
FILTERED WATER
Page 79
alpha/beta Hydroxy acids (glycolic acid, salicylic acid)
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
SKIN
97010-01
C97010A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SKH-1/NCTR
07/18/2000
NR
HYDROXGLYSAL
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NO CREAMNO SSL
02 - CTLCREAMNO SSL
03 - 4% AHA NO SSL
04 - 10% AHA NO SSL
05 - 2% BHA NO SSL
06 - 4% BHA NO SSL
07 - NO CREAM0.3 MED
08 - CTLCREAM0.3 MED
09 - 4% AHA 0.3 MED
10 - 10% AHA 0.3 MED
11 - 2% BHA 0.3 MED
12 - 4% BHA 0.3 MED
13 - NO CREAM0.6 MED
14 - CTLCREAM0.6 MED
15 - 4% AHA 0.6 MED
16 - 10% AHA 0.6 MED
17 - 2% BHA 0.6 MED
18 - 4% BHA 0.6 MED
20 - NO CREAM0.9 MED
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
NIH-31
Cosmetech Cream
Page 80
NIH-31
Cosmetech Cream
NIH-31
Cosmetech Cream
NIH-31
alpha/beta Hydroxy acids (glycolic acid, salicylic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
SKIN
97010-02
C97010A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SKH-1/NCTR
07/18/2000
NR
HYDROXGLYSAL
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NO CREAMNO SSL
02 - CTLCREAMNO SSL
03 - 4% AHA NO SSL
04 - 10% AHA NO SSL
05 - 2% BHA NO SSL
06 - 4% BHA NO SSL
07 - NO CREAM0.3 MED
08 - CTLCREAM0.3 MED
09 - 4% AHA 0.3 MED
10 - 10% AHA 0.3 MED
11 - 2% BHA 0.3 MED
12 - 4% BHA 0.3 MED
13 - NO CREAM0.6 MED
14 - CTLCREAM0.6 MED
15 - 4% AHA 0.6 MED
16 - 10% AHA 0.6 MED
17 - 2% BHA 0.6 MED
18 - 4% BHA 0.6 MED
20 - NO CREAM0.9 MED
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
NIH-31
Cosmetech Cream
Page 81
NIH-31
Cosmetech Cream
NIH-31
Cosmetech Cream
NIH-31
alpha-Pinene
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20302-01
C20302
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/29/2004
BN
80-56-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 100 ppm
04 - 100 ppm
05 - 200 ppm
06 - 200 ppm
07 - 400 ppm
08 - 400 ppm
09 - 800 ppm
10 - 800 ppm
11 - 1600 ppm
12 - 1600 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 82
AQUEOUS ETHANOL (95%)
AIR
alpha-Pinene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20302-02
C20302
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/29/2004
BN
80-56-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 100 ppm
04 - 100 ppm
05 - 200 ppm
06 - 200 ppm
07 - 400 ppm
08 - 400 ppm
09 - 800 ppm
10 - 800 ppm
11 - 1600 ppm
12 - 1600 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 83
alpha-Pinene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20302-03
C20302
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/28/2005
BN
80-56-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 ppm
04 - 25 ppm
05 - 50 ppm
06 - 50 ppm
07 - 100 ppm
08 - 100 ppm
09 - 200 ppm
10 - 200 ppm
11 - 400 ppm
12 - 400 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 84
alpha-Pinene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20302-04
C20302
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/28/2005
BN
80-56-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - control
03 - 25 ppm
04 - 25 ppm
05 - 50 ppm
06 - 50 ppm
07 - 100 ppm
08 - 100 ppm
09 - 200 ppm
10 - 200 ppm
11 - 400 ppm
12 - 400 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 85
9-Aminoacridine hydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05066-01
C61483B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/13/1985
BS
134-50-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 PPM
02 - 37.5 PPM
03 - 75.0 PPM
04 - 150.0 PPM
05 - 300.0 PPM
06 - 600.0 PPM
07 - 0.0 PPM
08 - 37.5 PPM
09 - 75.0 PPM
10 - 150.0 PPM
11 - 300.0 PPM
12 - 600.0 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 86
9-Aminoacridine hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05066-02
C61483B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/19/1985
BS
134-50-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 PPM
02 - 150 PPM
03 - 300 PPM
04 - 600 PPM
05 - 1200 PPM
06 - 2400 PPM
07 - 0.0 PPM
08 - 150 PPM
09 - 300 PPM
10 - 600 PPM
11 - 1200 PPM
12 - 2400 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 87
5-Amino-o-cresol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
20214-01
C20214
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
05/08/2006
BC
2835-95-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 2 mg/kg
04 - 2 mg/kg
05 - 4 mg/kg
06 - 4 mg/kg
07 - 8 mg/kg
08 - 8 mg/kg
09 - 16 mg/kg
10 - 16 mg/kg
11 - 32 mg/kg
12 - 32 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL (95%) : WATER (100:0)
Page 88
5-Amino-o-cresol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
20214-02
C20214
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/10/2006
BC
2835-95-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 8 mg/kg
04 - 8 mg/kg
05 - 16 mg/kg
06 - 16 mg/kg
07 - 32 mg/kg
08 - 32 mg/kg
09 - 64 mg/kg
10 - 64 mg/kg
11 - 128 mg/kg
12 - 128 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL (95%) : WATER (100:0)
Page 89
5-Amino-o-cresol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
SKIN
20214-99
C20214
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
05/08/2006
BC
2835-95-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 2 mg/kg
04 - 2 mg/kg
05 - 4 mg/kg
06 - 4 mg/kg
07 - 8 mg/kg
08 - 8 mg/kg
09 - 16 mg/kg
10 - 16 mg/kg
11 - 32 mg/kg
12 - 32 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL (95%) : WATER (100:0)
Page 90
1-Amino-2,4-dibromoanthraquinone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05061-01
C55458
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/12/1983
MA
81-49-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATED 71 UM
02 - 0.2% 71LM
03 - 0.5% 71MLM
04 - 1.0% 71MHM
05 - 2.0% 71HM
07 - UNTREATED 71UF
08 - 0.2% 71LF
09 - 0.5% 71MLF
10 - 1.0% 71MHF
11 - 2.0% 71HF
13 - 2.0% MALE
14 - 2.0% FEMALE
U
T
T
T
T
U
T
T
T
T
T
T
M
M
M
M
M
F
F
F
F
F
M
F
NIH-07
Page 91
1-Amino-2,4-dibromoanthraquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05061-02
C55458
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/20/1983
MA
81-49-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATED 71UM
02 - 1.0% 71LM
03 - 2.0% 71HM
04 - UNTREATED 71UF
05 - 1.0% 71LF
06 - 2.0% 71HF
U
T
T
U
T
T
M
M
M
F
F
F
NIH-07
Page 92
2-(4-Aminophenyl)-6-methyl-7-benzothiazole sulfonic acid
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05141-03
C61836
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/13/1986
SO
130-17-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.25%
04 - 0.25%
05 - 0.5%
06 - 0.5%
07 - 1.0%
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 93
2-(4-Aminophenyl)-6-methyl-7-benzothiazole sulfonic acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05141-04
C61836
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/18/1986
SO
130-17-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .25%
04 - .25%
05 - .5%
06 - .5%
07 - 1.0%
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 94
3-Aminopyridine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
06052-01
C06052
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
10/12/2010
BC
462-08-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 1.563 mg/kg
04 - 1.563 mg/kg
05 - 3.125 mg/kg
06 - 3.125 mg/kg
07 - 6.25 mg/kg
08 - 6.25 mg/kg
09 - 12.5 mg/kg
10 - 12.5 mg/kg
11 - 25 mg/kg
12 - 25 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 95
3-Aminopyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
06052-02
C06052
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/13/2010
BC
462-08-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 1.563 mg/kg
04 - 1.563 mg/kg
05 - 3.125 mg/kg
06 - 3.125 mg/kg
07 - 6.25 mg/kg
08 - 6.25 mg/kg
09 - 12.5 mg/kg
10 - 12.5 mg/kg
11 - 25 mg/kg
12 - 25 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 96
2-Aminopyridine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20139-01
C20139
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
10/05/2010
BC
504-29-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 3.125 mg/kg
04 - 3.125 mg/kg
05 - 6.25 mg/kg
06 - 6.25 mg/kg
07 - 12.5 mg/kg
08 - 12.5 mg/kg
09 - 25 mg/kg
10 - 25 mg/kg
11 - 50 mg/kg
12 - 50 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 97
2-Aminopyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20139-02
C20139
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/06/2010
BC
504-29-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 3.125 mg/kg
04 - 3.125 mg/kg
05 - 6.25 mg/kg
06 - 6.25 mg/kg
07 - 12.5 mg/kg
08 - 12.5 mg/kg
09 - 25 mg/kg
10 - 25 mg/kg
11 - 50 mg/kg
12 - 50 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 98
4-Aminopyridine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
06053-01
C06053
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
10/18/2010
BC
504-24-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 0.78 mg/kg
04 - 0.78 mg/kg
05 - 1.563 mg/kg
06 - 1.563 mg/kg
07 - 3.125 mg/kg
08 - 3.125 mg/kg
09 - 6.25 mg/kg
10 - 6.25 mg/kg
11 - 12.5 mg/kg
12 - 12.5 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 99
4-Aminopyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
06053-02
C06053
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/19/2010
BC
504-24-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 0.78 mg/kg
04 - 0.78 mg/kg
05 - 1.563 mg/kg
06 - 1.563 mg/kg
07 - 3.125 mg/kg
08 - 3.125 mg/kg
09 - 6.25 mg/kg
10 - 6.25 mg/kg
11 - 12.5 mg/kg
12 - 12.5 mg/kg
13 - 0 mg/kg Neuro
14 - 0.78 mg/kg Neuro
15 - 1.563mg/kg Neuro
16 - 3.125mg/kg Neuro
V
V
T
T
T
T
T
T
T
T
T
T
V
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
M
M
M
DEIONIZED WATER
Page 100
DL-amphetamine sulfate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05029-01
C55710
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/21/1982
MB
60-13-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 20 PPM LOW M
03 - 100 PPM HIGH M
05 - VEHICLE CONTROL
06 - 20 PPM LOW F
07 - 100 PPM HIGH F
V
T
T
V
T
T
M
M
M
F
F
F
NIH-07
Page 101
DL-amphetamine sulfate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05029-02
C55710
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/28/1982
MB
60-13-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 20 PPM LOW M
03 - 100 PPM HIGH M
05 - VEHICLE CONTROL
06 - 20 PPM LOW F
07 - 100 PPM HIGH F
V
T
T
V
T
T
M
M
M
F
F
F
NIH-07
Page 102
Androstenedione
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99024-01
C99024
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/14/2000
BC
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 10 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 20 MG/KG
11 - 50 MG/KG
12 - 50 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 103
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99024-02
C99024
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/21/2000
BC
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 10 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 20 MG/KG
11 - 50 MG/KG
12 - 50 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 104
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99024-03
C99024B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/15/2000
BC
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 10 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 20 MG/KG
11 - 50 MG/KG
12 - 50 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 105
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99024-04
C99024B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/22/2000
BC
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 10 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 20 MG/KG
11 - 50 MG/KG
12 - 50 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 106
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99024-05
C99024C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/22/2002
SO
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 10 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 20 MG/KG
11 - 50 MG/KG
12 - 50 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 107
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99024-06
C99024C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/24/2002
SO
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/KG
02 - 0.0 MG/KG
03 - 1.0 MG/KG
04 - 1.0 MG/KG
05 - 5.0 MG/KG
06 - 5.0 MG/KG
07 - 10.0 MG/KG
08 - 10.0 MG/KG
09 - 20.0 MG/KG
10 - 20.0 MG/KG
11 - 50.0 MG/KG
12 - 50.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 108
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99024-07
C99024C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/03/2003
SO
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 109
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99024-08
C99024C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/16/2002
SO
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 2 MG/KG
04 - 10 MG/KG
05 - 10 MG/KG
06 - 20 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
V
V
T
T
T
T
T
T
M
F
F
M
F
M
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 110
Androstenedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99024-98
C99024C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/22/2002
SO
63-05-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 10 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 20 MG/KG
11 - 50 MG/KG
12 - 50 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 111
Anthraquinone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88036-01
C88036
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/17/1994
BC
84-65-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1875 PPM
04 - 1875 PPM
05 - 3750 PPM
06 - 3750 PPM
07 - 7500 PPM
08 - 7500 PPM
09 - 15000 PPM
10 - 15000 PPM
11 - 30000 PPM
12 - 30000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 112
Anthraquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88036-02
C88036
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/26/1994
BC
84-65-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1875 PPM
04 - 1875 PPM
05 - 3750 PPM
06 - 3750 PPM
07 - 7500 PPM
08 - 7500 PPM
09 - 15000 PPM
10 - 15000 PPM
11 - 30000 PPM
12 - 30000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 113
Anthraquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88036-03
C88036
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/14/1994
BC
84-65-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 469 PPM
04 - 469 PPM
05 - 938 PPM
06 - 938 PPM
07 - 1875 PPM
08 - 1875 PPM
09 - 3750 PPM
10 - 3750 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 114
Anthraquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88036-04
C88036
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/31/1994
BC
84-65-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 833 PPM
04 - 833 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 7500 PPM
08 - 7500 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 115
Anthraquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88036-05
C88036
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/14/1994
BC
84-65-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 469 PPM
02 - 938 PPM
03 - 1875 PPM
04 - 3750 PPM
T
T
T
T
M
M
M
M
NIH-07
Page 116
Anthraquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88036-06
C88036
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/31/1994
BC
84-65-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 833 PPM
02 - 2500 PPM
03 - 7500 PPM
T
T
T
M
M
M
NIH-07
Page 117
Anthraquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
FEED
88036-99
C88036
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/29/1998
BC
84-65-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 469 PPM
04 - 469 PPM
05 - 938 PPM
06 - 938 PPM
07 - 3750 PPM
08 - 3750 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 118
Antimony potassium tartrate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INTP INJ
05178-05
C61858B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/08/1988
BC
28300-74-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.5 MG/KG
04 - 1.5 MG/KG
05 - 3.0 MG/KG
06 - 3.0 MG/KG
07 - 6.0 MG/KG
08 - 6.0 MG/KG
09 - 12.0 MG/KG
10 - 12.0 MG/KG
11 - 24.0 MG/KG
12 - 24.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
SALINE
Page 119
Antimony potassium tartrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INTP INJ
05178-06
C61858B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/02/1987
BC
28300-74-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.5 MG/KG
04 - 1.5 MG/KG
05 - 3.0 MG/KG
06 - 3.0 MG/KG
07 - 6.0 MG/KG
08 - 6.0 MG/KG
09 - 12.0 MG/KG
10 - 12.0 MG/KG
11 - 24.0 MG/KG
12 - 24.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
SALINE
Page 120
Antimony trioxide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20601-01
C20601
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
12/03/2007
BN
1309-64-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 3.75 mg/m3
04 - 3.75 mg/m3
05 - 7.5 mg/m3
06 - 7.5 mg/m3
07 - 15 mg/m3
08 - 15 mg/m3
09 - 30 mg/m3
10 - 30 mg/m3
11 - 60 mg/m3
12 - 60 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 121
Antimony trioxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20601-02
C20601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/03/2007
BN
1309-64-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 3.75 mg/m3
04 - 3.75 mg/m3
05 - 7.5 mg/m3
06 - 7.5 mg/m3
07 - 15 mg/m3
08 - 15 mg/m3
09 - 30 mg/m3
10 - 30 mg/m3
11 - 60 mg/m3
12 - 60 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 122
Antimony trioxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20601-03
C20601
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
09/22/2008
BN
1309-64-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 3 mg/m3
04 - 3 mg/m3
05 - 10 mg/m3
06 - 10 mg/m3
07 - 30 mg/m3
08 - 30 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 123
Antimony trioxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20601-04
C20601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/06/2008
BN
1309-64-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 3 mg/m3
04 - 3 mg/m3
05 - 10 mg/m3
06 - 10 mg/m3
07 - 30 mg/m3
08 - 30 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 124
Arsenic antioxidant mixture
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
20109-01
C20109
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/13/2000
IL
ANTIOXCOMBO2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 200/150 MG/L
02 - 200/150 MG/L+TPA
T
T
F
F
WATER
Page 125
Arsenic antioxidant mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
20109-02
C20109B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
07/24/2000
IL
ANTIOXCOMBO2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L +TPA
03 - 150/200 MG/L
04 - 150/200 MG/L+TPA
05 - 150/200 MG/L+NAO
06 - 150/200 +NAO+TPA
07 - 150/200 + VIT E
08 - 150/200+VITE+TPA
09 - NAO
10 - NAO + TPA
11 - VITAMIN E
12 - VIT E + TPA
V
P
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
WATER
ACETONE
WATER
Page 126
PHOSPHATE BUFFERED SALINE
CORN OIL
Antioxidant model (TRAMP) - N-acetylcysteine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20108-05
C20108C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6
12/04/2000
IL
616-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - NAC 125MG/KG
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 127
Antioxidant model (TRAMP) - N-acetylcysteine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20108-06
C20108C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TRAMP
12/04/2000
IL
616-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - NAC 125MG/KG
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 128
Antioxidant model (TRAMP) - Epigallocatechin gallate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20108-03
C20108B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6
12/04/2000
IL
989-51-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - EGCG 200MG/KG
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 129
Antioxidant model (TRAMP) - Epigallocatechin gallate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20108-04
C20108B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TRAMP
12/04/2000
IL
989-51-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - EGCG 200MG/KG
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 130
Antioxidant model (TRAMP) - NAO (spinach extract)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20108-01
C20108A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6
12/04/2000
IL
NAOSPINEXTR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 200MG/KG
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 131
Antioxidant model (TRAMP) - NAO (spinach extract) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20108-02
C20108A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TRAMP
12/04/2000
IL
NAOSPINEXTR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 200MG/KG
V
T
M
M
PHOSPHATE BUFFERED SALINE
Page 132
3'-Azido-3'-deoxythymidine (AIDS)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
20310-01
C20310C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3B6F1-+/Trp53(tm1Brd)
01/13/2005
NR
30516-87-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
612 - Vehicle 6 mo F
615 - AZT 120 6 mo F
912 - Vehicle 9 mo F
913 - AZT 40 9 mo F
914 - AZT 80 9 mo F
915 - AZT 120 9 mo F
917 - Vehicl PND1-8 F
918 - AZT 40 PND1-8 F
V
T
V
T
T
T
V
T
F
F
F
F
F
F
F
F
METHYLCELLULOSE/POLYSORBATE 80
Page 133
3'-Azido-3'-deoxythymidine (AIDS) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
20310-02
C20310C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3B6F1-+/Trp53(tm1Brd)
01/08/2005
NR
30516-87-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
612 - Vehicle 6 mo M
615 - AZT 120 6 mo M
912 - Vehicle 9 mo M
913 - AZT 40 9 mo M
914 - AZT 80 9 mo M
915 - AZT 120 9 mo M
917 - Vehicl PND 1-8 M
918 - AZT 40 PND 1-8 M
V
T
V
T
T
T
V
T
M
M
M
M
M
M
M
M
METHYLCELLULOSE/POLYSORBATE 80
Page 134
3'-Azido-3'-deoxythymidine (AIDS) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88072-01
C88072
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/03/1989
SO
30516-87-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
13 - 0 MG/KG
14 - 0 MG/KG
15 - 50 MG/KG
16 - 50 MG/KG
17 - 400 MG/KG
18 - 400 MG/KG
19 - 1000 MG/KG
20 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 135
3'-Azido-3'-deoxythymidine (AIDS) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88072-02
C88072
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/17/1989
SO
30516-87-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 125 MG/KG
04 - 125 MG/KG
05 - 250 MG/KG
06 - 250 MG/KG
07 - 500 MG/KG
08 - 500 MG/KG
09 - 1000 MG/KG
10 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 136
3'-Azido-3'-deoxythymidine (AIDS) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
89006-06
C88072
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/09/1990
SO
30516-87-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 30 MG/KG
04 - 30 MG/KG
05 - 60 MG/KG
06 - 60 MG/KG
07 - 120 MG/KG
08 - 120 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 137
3'-Azido-3'-deoxythymidine (AIDS) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
89006-07
C88072
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/16/1990
SO
30516-87-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 30 MG/KG
04 - 30 MG/KG
05 - 60 MG/KG
06 - 60 MG/KG
07 - 120 MG/KG
08 - 120 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 138
3'-Azido-3'-deoxythymidine and 2',3'-Dideoxycytidine
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
89007-02
C89007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/17/1989
SO
AZTDDCCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0/500 MG/KG
04 - 0/500 MG/KG
05 - 500/0 MG/KG
06 - 500/0 MG/KG
07 - 10/500 MG/KG
08 - 10/500 MG/KG
09 - 100/500 MG/KG
10 - 100/500 MG/KG
11 - 500/500 MG/KG
12 - 500/500 MG/KG
13 - 500/1000MG/KG
14 - 500/1000MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 139
3'-Azido-3'-deoxythymidine and 2',3'-Dideoxyinosine (AIDS initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
90001-01
C90001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/08/1990
SO
AZTDDICOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0 MG/KG 500MG/KG
04 - 0 MG/KG 500MG/KG
05 - 0 MG/KG 2K MG/KG
06 - 0 MG/KG 2K MG/KG
07 - 250MG/KG0 MG/KG
08 - 250MG/KG0 MG/KG
09 - 250MG/KG500MG/KG
10 - 250MG/KG500MG/KG
11 - 250MG/KG1K MG/KG
12 - 250MG/KG1K MG/KG
13 - 250MG/KG2K MG/KG
14 - 250MG/KG2K MG/KG
15 - 500MG/KG500MG/KG
16 - 500MG/KG500MG/KG
17 - 500MG/KG1K MG/KG
18 - 500MG/KG1K MG/KG
19 - 500MG/KG2K MG/KG
20 - 500MG/KG2K MG/KG
21 - 1K MG/KG0 MG/KG
22 - 1K MG/KG0 MG/KG
23 - 1K MG/KG500MG/KG
24 - 1K MG/KG500MG/KG
25 - 1K MG/KG1K MG/KG
26 - 1K MG/KG1K MG/KG
27 - 1K MG/KG2K MG/KG
28 - 1K MG/KG2K MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 140
AZT + CLARITHROMYCIN
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
97002-01
C97002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
11/08/1996
SO
AZTCLARITHRO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 500 MG/KG/DY
03 - 0 + 1250MG/KG/DY
04 - 0 + 2500MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200 +500MG/KG/DY
07 - 200+1250MG/KG/DY
08 - 200+2500MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400 +500MG/KG/DY
11 - 400+1250MG/KG/DY
12 - 400+2500MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 141
AZT + CLARITHROMYCIN (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
97002-02
C97002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
11/08/1996
SO
AZTCLARITHRO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 500 MG/KG/DY
03 - 0 + 1250MG/KG/DY
04 - 0 + 2500MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200 +500MG/KG/DY
07 - 200+1250MG/KG/DY
08 - 200+2500MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400 +500MG/KG/DY
11 - 400+1250MG/KG/DY
12 - 400+2500MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 142
AZT + CLARITHROMYCIN (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
97002-03
C97002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
11/08/1996
SO
AZTCLARITHRO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 500 MG/KG/DY
03 - 0 + 1250MG/KG/DY
04 - 0 + 2500MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200 +500MG/KG/DY
07 - 200+1250MG/KG/DY
08 - 200+2500MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400 +500MG/KG/DY
11 - 400+1250MG/KG/DY
12 - 400+2500MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 143
AZT + CLARITHROMYCIN (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
97002-04
C97002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
05/30/1997
SO
AZTCLARITHRO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 250 MG/KG/DY
03 - 0 + 500 MG/KG/DY
04 - 0 + 1000MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200 +250MG/KG/DY
07 - 200+500 MG/KG/DY
08 - 200+1000MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400 +250MG/KG/DY
11 - 400 +500MG/KG/DY
12 - 400+1000MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 144
AZT + CLARITHROMYCIN (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
97002-05
C97002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
05/30/1997
SO
AZTCLARITHRO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 250 MG/KG/DY
03 - 0 + 500 MG/KG/DY
04 - 0 + 1000MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200 +250MG/KG/DY
07 - 200+500 MG/KG/DY
08 - 200+1000MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400 +250MG/KG/DY
11 - 400 +500MG/KG/DY
12 - 400+1000MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 145
AZT + CLARITHROMYCIN (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
97002-06
C97002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
05/30/1997
SO
AZTCLARITHRO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 250 MG/KG/DY
03 - 0 + 500 MG/KG/DY
04 - 0 + 1000MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200 +250MG/KG/DY
07 - 200+500 MG/KG/DY
08 - 200+1000MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400 +250MG/KG/DY
11 - 400 +500MG/KG/DY
12 - 400+1000MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 146
AZT + RIFABUTIN (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
95999-01
C95999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
04/05/1995
SO
AZTRIFABUTIN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 0+80 MG/KG/DY
04 - 0+80 MG/KG/DY
05 - 0+320 MG/KG/DY
06 - 0+320 MG/KG/DY
07 - 0+640 MG/KG/DY
08 - 0+640 MG/KG/DY
09 - 200+0 MG/KG/DY
10 - 200+0 MG/KG/DY
11 - 200+80 MG/KG/DY
12 - 200+80 MG/KG/DY
13 - 200+320 MG/KG/DY
14 - 200+320 MG/KG/DY
15 - 200+640 MG/KG/DY
16 - 200+640 MG/KG/DY
17 - 400+0 MG/KG/DY
18 - 400+0 MG/KG/DY
19 - 400+80 MG/KG/DY
20 - 400+80 MG/KG/DY
21 - 400+320 MG/KG/DY
22 - 400+320 MG/KG/DY
23 - 400+640 MG/KG/DY
24 - 400+640 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.2 % AQUEOUS METHYLCELLULOSE
Page 147
AZT + RIFABUTIN (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
95999-02
C95999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
04/01/1995
SO
AZTRIFABUTIN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 0+80 MG/KG/DY
04 - 0+80 MG/KG/DY
05 - 0+320 MG/KG/DY
06 - 0+320 MG/KG/DY
07 - 0+640 MG/KG/DY
08 - 0+640 MG/KG/DY
09 - 200+0 MG/KG/DY
10 - 200+0 MG/KG/DY
11 - 200+80 MG/KG/DY
12 - 200+80 MG/KG/DY
13 - 200+320 MG/KG/DY
14 - 200+320 MG/KG/DY
15 - 200+640 MG/KG/DY
16 - 200+640 MG/KG/DY
17 - 400+0 MG/KG/DY
18 - 400+0 MG/KG/DY
19 - 400+80 MG/KG/DY
20 - 400+80 MG/KG/DY
21 - 400+320 MG/KG/DY
22 - 400+320 MG/KG/DY
23 - 400+640 MG/KG/DY
24 - 400+640 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 148
AZT + RIFABUTIN (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
95999-03
C95999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
04/06/1995
SO
AZTRIFABUTIN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 0+80 MG/KG/DY
04 - 0+80 MG/KG/DY
05 - 0+320 MG/KG/DY
06 - 0+320 MG/KG/DY
07 - 0+640 MG/KG/DY
08 - 0+640 MG/KG/DY
09 - 200+0 MG/KG/DY
10 - 200+0 MG/KG/DY
11 - 200+80 MG/KG/DY
12 - 200+80 MG/KG/DY
13 - 200+320 MG/KG/DY
14 - 200+320 MG/KG/DY
15 - 200+640 MG/KG/DY
16 - 200+640 MG/KG/DY
17 - 400+0 MG/KG/DY
18 - 400+0 MG/KG/DY
19 - 400+80 MG/KG/DY
20 - 400+80 MG/KG/DY
21 - 400+320 MG/KG/DY
22 - 400+320 MG/KG/DY
23 - 400+640 MG/KG/DY
24 - 400+640 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 149
AZT+3TC+NVP combination
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
20310-03
C20310B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3B6F1-+/Trp53(tm1Brd)
01/05/2007
NR
AZT3TCCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
12 - Vehicle
15 - AZT 60
20 - 3TC 37.5
22 - NVP 10.5
24 - AZT 60 3TC 37.5
26 - A20,3T12.5,NV3.5
28 - AZT40,3TC25,NVP7
30 - A60,3T37.5,N10.5
V
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
METHYLCELLULOSE/POLYSORBATE 80
Page 150
AZT+3TC+NVP combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
20310-04
C20310B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3B6F1-+/Trp53(tm1Brd)
01/05/2007
NR
AZT3TCCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
12 - Vehicle
15 - AZT 60
20 - 3TC 37.5
22 - NVP 10.5
24 - AZT 60 3TC 37.5
26 - A20,3T12.5,NV3.5
28 - AZT40,3TC25,NVP7
30 - A60,3T37.5,N10.5
V
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
METHYLCELLULOSE/POLYSORBATE 80
Page 151
AZT/Drug Combinations Transplacental/Neonatal Study
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20311-03
C20311B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
01/01/2007
NR
AIDSDRUGSNEO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
160 - AZT 40
161 - AZT 26.6
162 - AZT 13.3
163 - AZT 40 +3TC 20
164 - AZT 26.63TC 13.3
165 - AZT 13.33TC 6.7
166 - 40+20+ NVP 56
167 - 26.6+13.3+37.2
168 - 13.3+6.7NVP 18.6
169 - 40+20+ NFV 168
170 - 26.6+13.3+NFV112
171 - 13.3+6.7+NFV 56
172 - 40+20+ EFV 40
173 - 26.6+13.3EFV26.6
174 - 13.3+6.7EFV 13.3
195 - SOLVENT ONLY PUP
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
METHYLCELLULOSE/POLYSORBATE 80
Page 152
AZT/Drug Combinations Transplacental/Neonatal Study (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20311-04
C20311B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
01/01/2007
NR
AIDSDRUGSNEO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
160 - AZT 40
161 - AZT 26.6
162 - AZT 13.3
163 - AZT 40 +3TC 20
164 - AZT 26.63TC 13.3
165 - AZT 13.33TC 6.7
166 - 40+20+ NVP 56
167 - 26.6+13.3+37.2
168 - 13.3+6.7NVP 18.6
169 - 40+20+ NFV 168
170 - 26.6+13.3+NFV112
171 - 13.3+6.7+NFV 56
172 - 40+20+ EFV 40
173 - 26.6+13.3EFV26.6
174 - 13.3+6.7EFV 13.3
195 - SOLVENT ONLY PUP
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
METHYLCELLULOSE/POLYSORBATE 80
Page 153
AZT/Drug Combinations Transplacental Carcinogenesis Study
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
IN-UTERO
20311-01
C20311
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
04/29/2004
NR
AIDSTHERAPEU
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
17 - AZT-H to 0
18 - AZT-M to 0
19 - AZT-L to 0
20 - AZT-H/3TC-H to 0
21 - AZT-M/3TC-M to 0
22 - AZT-L/3TC-L to 0
23 - AZTH/3TCH/NVPH/0
24 - AZTM/3TCM/NVPM/0
25 - AZTL/3TCL/NVPL/0
26 - AZTH/3TCH/NFVH/0
27 - AZTM/3TCM/NFVM/0
28 - AZTL/3TCL/NFVL/0
29 - SOLVENT to 0
T
T
T
T
T
T
T
T
T
T
T
T
V
M
M
M
M
M
M
M
M
M
M
M
M
M
METHYLCELLULOSE/POLYSORBATE 80
Page 154
AZT/Drug Combinations Transplacental Carcinogenesis Study (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
IN-UTERO
20311-02
C20311
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
04/29/2004
NR
AIDSTHERAPEU
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
17 - AZT-H to 0
18 - AZT-M to 0
19 - AZT-L to 0
20 - AZT-H/3TC-H to 0
21 - AZT-M/3TC-M to 0
22 - AZT-L/3TC-L to 0
23 - AZTH/3TCH/NVPH/0
24 - AZTM/3TCM/NVPM/0
25 - AZTL/3TCL/NVPL/0
26 - AZTH/3TCH/NFVH/0
27 - AZTM/3TCM/NFVM/0
28 - AZTL/3TCL/NFVL/0
29 - SOLVENT to 0
T
T
T
T
T
T
T
T
T
T
T
T
V
F
F
F
F
F
F
F
F
F
F
F
F
F
METHYLCELLULOSE/POLYSORBATE 80
Page 155
AZT + Isoniazid (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93001-01
C93001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/08/1993
SO
AZTISONIAZID
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0/0 MG/KG/DY
02 - 0/0 MG/KG/DY
03 - 100/0 MG/KG/DY
04 - 100/0 MG/KG/DY
05 - 200/0 MG/KG/DY
06 - 200/0 MG/KG/DY
07 - 400/0 MG/KG/DY
08 - 400/0 MG/KG/DY
09 - 0/50 MG/KG/DY
10 - 0/50 MG/KG/DY
11 - 100/50 MG/KG/DY
12 - 100/50 MG/KG/DY
13 - 200/50 MG/KG/DY
14 - 200/50 MG/KG/DY
15 - 400/50 MG/KG/DY
16 - 400/50 MG/KG/DY
17 - 0/100 MG/KG/DY
18 - 0/100 MG/KG/DY
19 - 100/100 MG/KG/DY
20 - 100/100 MG/KG/DY
21 - 200/100 MG/KG/DY
22 - 200/100 MG/KG/DY
23 - 400/100 MG/KG/DY
24 - 400/100 MG/KG/DY
25 - 0/150 MG/KG/DY
26 - 0/150 MG/KG/DY
27 - 100/150 MG/KG/DY
28 - 100/150 MG/KG/DY
29 - 200/150 MG/KG/DY
30 - 200/150 MG/KG/DY
31 - 400/150 MG/KG/DY
32 - 400/150 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 156
AZT + Isoniazid (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93001-02
C93001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/15/1993
SO
AZTISONIAZID
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0/0 MG/KG/DY
02 - 0/0 MG/KG/DY
03 - 100/0 MG/KG/DY
04 - 100/0 MG/KG/DY
05 - 200/0 MG/KG/DY
06 - 200/0 MG/KG/DY
07 - 400/0 MG/KG/DY
08 - 400/0 MG/KG/DY
09 - 0/50 MG/KG/DY
10 - 0/50 MG/KG/DY
11 - 100/50 MG/KG/DY
12 - 100/50 MG/KG/DY
13 - 200/50 MG/KG/DY
14 - 200/50 MG/KG/DY
15 - 400/50 MG/KG/DY
16 - 400/50 MG/KG/DY
17 - 0/100 MG/KG/DY
18 - 0/100 MG/KG/DY
19 - 100/100 MG/KG/DY
20 - 100/100 MG/KG/DY
21 - 200/100 MG/KG/DY
22 - 200/100 MG/KG/DY
23 - 400/100 MG/KG/DY
24 - 400/100 MG/KG/DY
25 - 0/150 MG/KG/DY
26 - 0/150 MG/KG/DY
27 - 100/150 MG/KG/DY
28 - 100/150 MG/KG/DY
29 - 200/150 MG/KG/DY
30 - 200/150 MG/KG/DY
31 - 400/150 MG/KG/DY
32 - 400/150 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 157
AZT + Methadone HCl (AIDS)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
92014-01
C92014
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/03/1992
SO
AZTMETHCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - VEHICLE
03 - 200MG/KGVEHICLE
04 - 200MG/KGVEHICLE
05 - 400MG/KGVEHICLE
06 - 400MG/KGVEHICLE
07 - 800MG/KGVEHICLE
08 - 800MG/KGVEHICLE
09 - VEHICLE 5 MG/KG
10 - VEHICLE 5 MG/KG
11 - 200MG/KG5 MG/KG
12 - 200MG/KG5 MG/KG
13 - 400MG/KG5 MG/KG
14 - 400MG/KG5 MG/KG
15 - 800MG/KG5 MG/KG
16 - 800MG/KG5 MG/KG
17 - VEHICLE 15 MG/KG
18 - VEHICLE 15 MG/KG
19 - 200MG/KG15 MG/KG
20 - 200MG/KG15 MG/KG
21 - 400MG/KG15 MG/KG
22 - 400MG/KG15 MG/KG
23 - 800MG/KG15 MG/KG
24 - 800MG/KG15 MG/KG
25 - VEHICLE 30 MG/KG
26 - VEHICLE 30 MG/KG
27 - 200MG/KG30 MG/KG
28 - 200MG/KG30 MG/KG
29 - 400MG/KG30 MG/KG
30 - 400MG/KG30 MG/KG
31 - 800MG/KG30 MG/KG
32 - 800MG/KG30 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 158
AZT + Methadone HCl (AIDS) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
92014-02
C92014
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/10/1992
SO
AZTMETHCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE VEHICLE
02 - VEHICLE VEHICLE
03 - 200MG/KGVEHICLE
04 - 200MG/KGVEHICLE
05 - 400MG/KGVEHICLE
06 - 400MG/KGVEHICLE
07 - 800MG/KGVEHICLE
08 - 800MG/KGVEHICLE
09 - VEHICLE 5 MG/KG
10 - VEHICLE 5 MG/KG
11 - 200MG/KG5 MG/KG
12 - 200MG/KG5 MG/KG
13 - 400MG/KG5 MG/KG
14 - 400MG/KG5 MG/KG
15 - 800MG/KG5 MG/KG
16 - 800MG/KG5 MG/KG
17 - VEHICLE 15 MG/KG
18 - VEHICLE 15 MG/KG
19 - 200MG/KG15 MG/KG
20 - 200MG/KG15 MG/KG
21 - 400MG/KG15 MG/KG
22 - 400MG/KG15 MG/KG
23 - 800MG/KG15 MG/KG
24 - 800MG/KG15 MG/KG
25 - VEHICLE 30 MG/KG
26 - VEHICLE 30 MG/KG
27 - 200MG/KG30 MG/KG
28 - 200MG/KG30 MG/KG
29 - 400MG/KG30 MG/KG
30 - 400MG/KG30 MG/KG
31 - 800MG/KG30 MG/KG
32 - 800MG/KG30 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 159
AZT + Nitazoxanide (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
98002-01
C98002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
09/12/1997
SO
AZT+NITAZOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 250 MG/KG/DY
03 - 0 + 500 MG/KG/DY
04 - 0 + 1000MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200+ 250MG/KG/DY
07 - 200+ 500MG/KG/DY
08 - 200+1000MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400+ 250MG/KG/DY
11 - 400+ 500MG/KG/DY
12 - 400+1000MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 160
AZT + Nitazoxanide (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
98002-02
C98002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
09/12/1997
SO
AZT+NITAZOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 + 0 MG/KG/DY
02 - 0 + 250 MG/KG/DY
03 - 0 + 500 MG/KG/DY
04 - 0 + 1000MG/KG/DY
05 - 200 + 0 MG/KG/DY
06 - 200 +250MG/KG/DY
07 - 200 +500MG/KG/DY
08 - 200+1000MG/KG/DY
09 - 400 + 0 MG/KG/DY
10 - 400 +250MG/KG/DY
11 - 400 +500MG/KG/DY
12 - 400+1000MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 161
AZT + Nitazoxanide (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
98002-03
C98002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
09/17/1997
SO
AZT+NITAZOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 +0 MG/KG/DY
02 - 0 + 500 MG/KG/DY
03 - 200 + 0 MG/KG/DY
04 - 200+500 MG/KG/DY
05 - 400 + 0 MG/KG/DY
06 - 400+250 MG/KG/DY
07 - 400+500 MG/KG/DY
08 - 400+1000MG/KG/DY
U
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 162
AZT + Nitazoxanide (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
98002-04
C98002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/02/1998
SO
AZT+NITAZOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+500 MG/KG/DY
08 - 0+500 MG/KG/DY
09 - 200+500 MG/KG/DY
10 - 200+500 MG/KG/DY
11 - 400+500 MG/KG/DY
12 - 400+500 MG/KG/DY
13 - 0+1000 MG/KG/DY
14 - 0+1000 MG/KG/DY
15 - 200+1000MG/KG/DY
16 - 200+1000MG/KG/DY
17 - 400+1000MG/KG/DY
18 - 400+1000MG/KG/DY
19 - 0+250 MG/KG/DY
20 - 0+250 MG/KG/DY
21 - 200+250 MG/KG/DY
22 - 200+250 MG/KG/DY
23 - 400+250 MG/KG/DY
24 - 400+250 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 163
AZT + Nitazoxanide (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
98002-05
C98002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/01/1998
SO
AZT+NITAZOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+500 MG/KG/DY
08 - 0+500 MG/KG/DY
09 - 200+500 MG/KG/DY
10 - 200+500 MG/KG/DY
11 - 400+500 MG/KG/DY
12 - 400+500 MG/KG/DY
13 - 0+1000 MG/KG/DY
14 - 0+1000 MG/KG/DY
15 - 200+1000MG/KG/DY
16 - 200+1000MG/KG/DY
17 - 400+1000MG/KG/DY
18 - 400+1000MG/KG/DY
19 - 0+250 MG/KG/DY
20 - 0+250 MG/KG/DY
21 - 200+250 MG/KG/DY
22 - 200+250 MG/KG/DY
23 - 400+250 MG/KG/DY
24 - 400+250 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 164
AZT + Nitazoxanide (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
98002-06
C98002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/08/1998
SO
AZT+NITAZOX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+500 MG/KG/DY
08 - 0+500 MG/KG/DY
09 - 200+500 MG/KG/DY
10 - 200+500 MG/KG/DY
11 - 400+500 MG/KG/DY
12 - 400+500 MG/KG/DY
13 - 0+1000 MG/KG/DY
14 - 0+1000 MG/KG/DY
15 - 200+1000MG/KG/DY
16 - 200+1000MG/KG/DY
17 - 400+1000MG/KG/DY
18 - 400+1000MG/KG/DY
19 - 0+250 MG/KG/DY
20 - 0+250 MG/KG/DY
21 - 200+250 MG/KG/DY
22 - 200+250 MG/KG/DY
23 - 400+250 MG/KG/DY
24 - 400+250 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 165
AZT + Pyrazinamide combination (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93003-01
C93003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/30/1993
SO
AZTZINAMIDE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+1000 MG/KG/DY
08 - 0+1000 MG/KG/DY
09 - 200+1000MG/KG/DY
10 - 200+1000MG/KG/DY
11 - 400+1000MG/KG/DY
12 - 400+1000MG/KG/DY
13 - 0+1500 MG/KG/DY
14 - 0+1500 MG/KG/DY
15 - 200+1500MG/KG/DY
16 - 200+1500MG/KG/DY
17 - 400+1500MG/KG/DY
18 - 400+1500MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 166
AZT + Pyrazinamide combination (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93003-02
C93003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/30/1993
SO
AZTZINAMIDE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+1000 MG/KG/DY
08 - 0+1000 MG/KG/DY
09 - 200+1000MG/KG/DY
10 - 200+1000MG/KG/DY
11 - 400+1000MG/KG/DY
12 - 400+1000MG/KG/DY
13 - 0+1500 MG/KG/DY
14 - 0+1500 MG/KG/DY
15 - 200+1500MG/KG/DY
16 - 200+1500MG/KG/DY
17 - 400+1500MG/KG/DY
18 - 400+1500MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 167
AZT + Pyrazinamide combination (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
93003-03
C93003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
02/03/1995
SO
AZTZINAMIDE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 300 MG/KG/DY
04 - 300 MG/KG/DY
05 - 1500 MG/KG/DY
06 - 1500 MG/KG/DY
07 - 3000 MG/KG/DY
08 - 3000 MG/KG/DY
09 - 200 MG/KG/DY
10 - 200 MG/KG/DY
11 - 200+300 MG/KG/DY
12 - 200+300 MG/KG/DY
13 - 200+1500MG/KG/DY
14 - 200+1500MG/KG/DY
15 - 200+3000MG/KG/DY
16 - 200+3000MG/KG/DY
17 - 400 MG/KG/DY
18 - 400 MG/KG/DY
19 - 400+300 MG/KG/DY
20 - 400+300 MG/KG/DY
21 - 400+1500MG/KG/DY
22 - 400+1500MG/KG/DY
23 - 400+3000MG/KG/DY
24 - 400+3000MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 168
AZT + Pyrazinamide combination (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
93003-04
C93003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
02/08/1995
SO
AZTZINAMIDE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 300 MG/KG/DY
03 - 1500 MG/KG/DY
04 - 3000 MG/KG/DY
05 - 200 MG/KG/DY
06 - 200+300 MG/KG/DY
07 - 200+1500MG/KG/DY
08 - 200+3000MG/KG/DY
09 - 400 MG/KG/DY
10 - 400+300 MG/KG/DY
11 - 400+1500MG/KG/DY
12 - 400+3000MG/KG/DY
V
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 169
AZT + Rifampin (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93002-01
C93002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/25/1993
SO
AZTRIFAMPIN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE+VEHICLE
02 - VEHICLE+VEHICLE
03 - 100+0 MG/KG/DY
04 - 100+0 MG/KG/DY
05 - 200+0 MG/KG/DY
06 - 200+0 MG/KG/DY
07 - 400+0 MG/KG/DY
08 - 400+0 MG/KG/DY
09 - 0+100 MG/KG/DY
10 - 0+100 MG/KG/DY
11 - 100+100 MG/KG/DY
12 - 100+100 MG/KG/DY
13 - 200+100 MG/KG/DY
14 - 200+100 MG/KG/DY
15 - 400+100 MG/KG/DY
16 - 400+100 MG/KG/DY
17 - 0+200 MG/KG/DY
18 - 0+200 MG/KG/DY
19 - 100+200 MG/KG/DY
20 - 100+200 MG/KG/DY
21 - 200+200 MG/KG/DY
22 - 200+200 MG/KG/DY
23 - 400+200 MG/KG/DY
24 - 400+200 MG/KG/DY
25 - 0+400 MG/KG/DY
26 - 0+400 MG/KG/DY
27 - 100+400 MG/KG/DY
28 - 100+400 MG/KG/DY
29 - 200+400 MG/KG/DY
30 - 200+400 MG/KG/DY
31 - 400+400 MG/KG/DY
32 - 400+400 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
WATER
Page 170
AZT + Rifampin (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93002-02
C93002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/07/1993
SO
AZTRIFAMPIN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 100+0 MG/KG/DY
04 - 100+0 MG/KG/DY
05 - 200+0 MG/KG/DY
06 - 200+0 MG/KG/DY
07 - 400+0 MG/KG/DY
08 - 400+0 MG/KG/DY
09 - 0+100 MG/KG/DY
10 - 0+100 MG/KG/DY
11 - 100+100 MG/KG/DY
12 - 100+100 MG/KG/DY
13 - 200+100 MG/KG/DY
14 - 200+100 MG/KG/DY
15 - 400+100 MG/KG/DY
16 - 400+100 MG/KG/DY
17 - 0+200 MG/KG/DY
18 - 0+200 MG/KG/DY
19 - 100+200 MG/KG/DY
20 - 100+200 MG/KG/DY
21 - 200+200 MG/KG/DY
22 - 200+200 MG/KG/DY
23 - 400+200 MG/KG/DY
24 - 400+200 MG/KG/DY
25 - 0+400 MG/KG/DY
26 - 0+400 MG/KG/DY
27 - 100+400 MG/KG/DY
28 - 100+400 MG/KG/DY
29 - 200+400 MG/KG/DY
30 - 200+400 MG/KG/DY
31 - 400+400 MG/KG/DY
32 - 400+400 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
WATER
Page 171
AZT + TMP/SMX (mixture) combination
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-01
C95004
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/30/1995
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+1000 MG/KG/DY
08 - 0+1000 MG/KG/DY
09 - 200+1000MG/KG/DY
10 - 200+1000MG/KG/DY
11 - 400+1000MG/KG/DY
12 - 400+1000MG/KG/DY
13 - 0+2000 MG/KG/DY
14 - 0+2000 MG/KG/DY
15 - 200+2000MG/KG/DY
16 - 200+2000MG/KG/DY
17 - 400+2000MG/KG/DY
18 - 400+2000MG/KG/DY
19 - 0+3000 MG/KG/DY
20 - 0+3000 MG/KG/DY
21 - 200+3000MG/KG/DY
22 - 200+3000MG/KG/DY
23 - 400+3000MG/KG/DY
24 - 400+3000MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 172
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
45-DAY
GAVAGE
95004-02
C95004
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/30/1995
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+1000 MG/KG/DY
08 - 0+1000 MG/KG/DY
09 - 200+1000MG/KG/DY
10 - 200+1000MG/KG/DY
11 - 400+1000MG/KG/DY
12 - 400+1000MG/KG/DY
13 - 0+2000 MG/KG/DY
14 - 0+2000 MG/KG/DY
15 - 200+2000MG/KG/DY
16 - 200+2000MG/KG/DY
17 - 400+2000MG/KG/DY
18 - 400+2000MG/KG/DY
19 - 0+3000 MG/KG/DY
20 - 0+3000 MG/KG/DY
21 - 200+3000MG/KG/DY
22 - 200+3000MG/KG/DY
23 - 400+3000MG/KG/DY
24 - 400+3000MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.2 % AQUEOUS METHYLCELLULOSE
Page 173
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
45-DAY
GAVAGE
95004-03
C95004
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/06/1995
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0 MG/KG/DY
02 - 0+0 MG/KG/DY
03 - 200+0 MG/KG/DY
04 - 200+0 MG/KG/DY
05 - 400+0 MG/KG/DY
06 - 400+0 MG/KG/DY
07 - 0+1000 MG/KG/DY
08 - 0+1000 MG/KG/DY
09 - 200+1000MG/KG/DY
10 - 200+1000MG/KG/DY
11 - 400+1000MG/KG/DY
12 - 400+1000MG/KG/DY
13 - 0+2000 MG/KG/DY
14 - 0+2000 MG/KG/DY
15 - 200+2000MG/KG/DY
16 - 200+2000MG/KG/DY
17 - 400+2000MG/KG/DY
18 - 400+2000MG/KG/DY
19 - 0+3000 MG/KG/DY
20 - 0+3000 MG/KG/DY
21 - 200+3000MG/KG/DY
22 - 200+3000MG/KG/DY
23 - 400+3000MG/KG/DY
24 - 400+3000MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 174
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-04
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/08/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0+0
02 - 50+0+0
03 - 100+0+0
04 - 200+0+0
05 - 0+500+0
06 - 50+500+0
07 - 100+500 +0
08 - 200+500 +0
09 - 0+1000+0
10 - 50+1000 +0
11 - 100+1000+0
12 - 200+1000+0
13 - 0+2000+0
14 - 50+2000 +0
15 - 100+2000+0
16 - 200+2000+0
17 - 0+0+50
18 - 100+1000+50
19 - 200+1000+50
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.2 % AQUEOUS METHYLCELLULOSE
Page 175
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-05
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/08/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0+0
02 - 50+0+0
03 - 100+0+0
04 - 200+0+0
05 - 0+500+0
06 - 50+500+0
07 - 100+500 +0
08 - 200+500 +0
09 - 0+1000+0
10 - 50+1000 +0
11 - 100+1000+0
12 - 200+1000+0
13 - 0+2000+0
14 - 50+2000 +0
15 - 100+2000+0
16 - 200+2000+0
17 - 0+0+50
18 - 100+1000+50
19 - 200+1000+50
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 176
(UNSPECIFIED)
0.2 % AQUEOUS METHYLCELLULOSE
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-06
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/06/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0+0
02 - 50+0+0
03 - 100+0+0
04 - 200+0+0
05 - 0+500+0
06 - 50+500+0
07 - 100+500 +0
08 - 200+500 +0
09 - 0+1000+0
10 - 50+1000 +0
11 - 100+1000+0
12 - 200+1000+0
13 - 0+2000+0
14 - 50+2000 +0
15 - 100+2000+0
16 - 200+2000+0
17 - 0+0+50
18 - 100+1000+50
19 - 200+1000+50
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.2 % AQUEOUS METHYLCELLULOSE
Page 177
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-07
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/07/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0+0
02 - 50+0+0
03 - 100+0+0
04 - 200+0+0
05 - 0+500+0
06 - 50+500+0
07 - 100+500 +0
08 - 200+500 +0
09 - 0+1000+0
10 - 50+1000 +0
11 - 100+1000+0
12 - 200+1000+0
13 - 0+2000+0
14 - 50+2000 +0
15 - 100+2000+0
16 - 200+2000+0
17 - 0+0+50
18 - 100+1000+50
19 - 200+1000+50
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 178
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-08
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/13/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0+0
02 - 50+0+0
03 - 100+0+0
04 - 200+0+0
05 - 0+500+0
06 - 50+500+0
07 - 100+500 +0
08 - 200+500 +0
09 - 0+1000+0
10 - 50+1000 +0
11 - 100+1000+0
12 - 200+1000+0
13 - 0+2000+0
14 - 50+2000 +0
15 - 100+2000+0
16 - 200+2000+0
17 - 0+0+50
18 - 100+1000+50
19 - 200+1000+50
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.2 % AQUEOUS METHYLCELLULOSE
Page 179
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-09
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/14/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0+0
02 - 50+0+0
03 - 100+0+0
04 - 200+0+0
05 - 0+500+0
06 - 50+500+0
07 - 100+500 +0
08 - 200+500 +0
09 - 0+1000+0
10 - 50+1000 +0
11 - 100+1000+0
12 - 200+1000+0
13 - 0+2000+0
14 - 50+2000 +0
15 - 100+2000+0
16 - 200+2000+0
17 - 0+0+50
18 - 100+1000+50
19 - 200+1000+50
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 180
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-10
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/15/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 50+0+0
02 - 50+0+0
03 - 100+0+0
04 - 100+0+0
05 - 200+0+0
06 - 200+0+0
07 - 50+500+0
08 - 50+500+0
09 - 100+500 +0
10 - 100+500 +0
11 - 200+500 +0
12 - 200+500 +0
13 - 50+1000 +0
14 - 50+1000 +0
15 - 100+1000+0
16 - 100+1000+0
17 - 200+1000+0
18 - 200+1000+0
19 - 50+2000 +0
20 - 50+2000 +0
21 - 100+2000+0
22 - 100+2000+0
23 - 200+2000+0
24 - 200+2000+0
25 - 0+0+50
26 - 0+0+50
27 - 100+1000+50
28 - 100+1000+50
29 - 200+1000+50
30 - 200+1000+50
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 181
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-11
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/22/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 50+0+0
02 - 50+0+0
03 - 100+0+0
04 - 100+0+0
05 - 200+0+0
06 - 200+0+0
07 - 50+500+0
08 - 50+500+0
09 - 100+500 +0
10 - 100+500 +0
11 - 200+500 +0
12 - 200+500 +0
13 - 50+1000 +0
14 - 50+1000 +0
15 - 100+1000+0
16 - 100+1000+0
17 - 200+1000+0
18 - 200+1000+0
19 - 50+2000 +0
20 - 50+2000 +0
21 - 100+2000+0
22 - 100+2000+0
23 - 200+2000+0
24 - 200+2000+0
25 - 0+0+50
26 - 0+0+50
27 - 100+1000+50
28 - 100+1000+50
29 - 200+1000+50
30 - 200+1000+50
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 182
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-12
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/27/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 50+0+0
02 - 50+0+0
03 - 100+0+0
04 - 100+0+0
05 - 200+0+0
06 - 200+0+0
07 - 50+500+0
08 - 50+500+0
09 - 100+500 +0
10 - 100+500 +0
11 - 200+500 +0
12 - 200+500 +0
13 - 50+1000 +0
14 - 50+1000 +0
15 - 100+1000+0
16 - 100+1000+0
17 - 200+1000+0
18 - 200+1000+0
19 - 50+2000 +0
20 - 50+2000 +0
21 - 100+2000+0
22 - 100+2000+0
23 - 200+2000+0
24 - 200+2000+0
25 - 0+0+50
26 - 0+0+50
27 - 100+1000+50
28 - 100+1000+50
29 - 200+1000+50
30 - 200+1000+50
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 183
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-13
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/03/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 50+0+0
02 - 50+0+0
03 - 100+0+0
04 - 100+0+0
05 - 200+0+0
06 - 200+0+0
07 - 50+500+0
08 - 50+500+0
09 - 100+500 +0
10 - 100+500 +0
11 - 200+500 +0
12 - 200+500 +0
13 - 50+1000 +0
14 - 50+1000 +0
15 - 100+1000+0
16 - 100+1000+0
17 - 200+1000+0
18 - 200+1000+0
19 - 50+2000 +0
20 - 50+2000 +0
21 - 100+2000+0
22 - 100+2000+0
23 - 200+2000+0
24 - 200+2000+0
25 - 0+0+50
26 - 0+0+50
27 - 100+1000+50
28 - 100+1000+50
29 - 200+1000+50
30 - 200+1000+50
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 184
(UNSPECIFIED)
AZT + TMP/SMX (mixture) combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95004-14
C95004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/15/1996
SO
AZTTMPSMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0+0+0
02 - 200+500+0
03 - 100+1000+0
04 - 200+1000+0
05 - 100+2000+0
06 - 200+2000+0
V
T
T
T
T
T
F
F
F
F
F
F
0.2 % AQUEOUS METHYLCELLULOSE
Page 185
AZT transplacental carcinogenesis study
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
IN-UTERO
99022-02
C99022
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
06/19/1999
SO
30516-87-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 50 MG/KG/DY
03 - 100 MG/KG/DY
04 - 200 MG/KG/DY
05 - 300 MG/KG/DY
06 - 0 MG/KG/DY
07 - 50 MG/KG/DY
08 - 100 MG/KG/DY
09 - 200 MG/KG/DY
10 - 300 MG/KG/DY
11 - 0 MG/KG/DY
12 - 50 MG/KG/DY
13 - 100 MG/KG/DY
14 - 200 MG/KG/DY
15 - 300 MG/KG/DY
16 - 0 MG/KG/DY
17 - 50 MG/KG/DY
18 - 100 MG/KG/DY
19 - 200 MG/KG/DY
20 - 300 MG/KG/DY
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
F
F
F
F
F
M
M
M
M
M
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 186
Barium chloride dihydrate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05127-01
C61074B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/09/1985
MA
10326-27-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 187
Barium chloride dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05127-02
C61074B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/08/1985
MA
10326-27-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 188
Benzaldehyde
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05006-05
C56133
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/18/1982
SO
100-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 400. MG/KG
04 - 400. MG/KG
05 - 200. MG/KG
06 - 200. MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 189
Benzaldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05006-06
C56133
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/19/1982
SO
100-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 400. MG/KG
04 - 600. MG/KG
05 - 200. MG/KG
06 - 300. MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 190
Benzethonium chloride
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05102-03
C61494A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/02/1985
BC
121-54-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 1.56 MG/KG MALE
04 - 1.56 MG/KG F
05 - 3.125 MG/KG MALE
06 - 3.125 MG/KG FEM
07 - 6.25 MG/KG MALE
08 - 6.25 MG/KG FEM
09 - 12.5 MG/KG MALE
10 - 12.5 MG/KG FEM
11 - 25 MG/KG MALE
12 - 25 MG/KG FEMALE
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 191
Benzethonium chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05102-04
C61494A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/01/1985
BC
121-54-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 1.56 MG/KG MALE
04 - 1.56 MG/KG F
05 - 3.125 MG/KG MALE
06 - 3.125 MG/KG FEM
07 - 6.25 MG/KG MALE
08 - 6.25 MG/KG FEM
09 - 12.5 MG/KG MALE
10 - 12.5 MG/KG FEM
11 - 25 MG/KG MALE
12 - 25 MG/KG FEMALE
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 192
Benzethonium chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05102-05
C61494B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/15/1987
BC
121-54-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - .15 MG/KG
04 - .15 MG/KG
05 - 0.5 MG/KG
06 - 0.5 MG/KG
07 - 1.5 MG/KG
08 - 1.5 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 193
Benzethonium chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05102-06
C61494B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/22/1987
BC
121-54-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - .15 MG/KG
04 - .15 MG/KG
05 - 0.5 MG/KG
06 - 0.5 MG/KG
07 - 1.5 MG/KG
08 - 1.5 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 194
Benzonitrile
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05138-03
C61676
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/09/1986
BC
100-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 19 MG/KG
03 - 37.5 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 300 MG/KG
07 - 0 MG/KG
08 - 19 MG/KG
09 - 37.5 MG/KG
10 - 75 MG/KG
11 - 150 MG/KG
12 - 300 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 195
Benzonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05138-04
C61676
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/16/1986
BC
100-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 37.5 MG/KG
03 - 75 MG/KG
04 - 150 MG/KG
05 - 300 MG/KG
06 - 600 MG/KG
07 - 0 MG/KG
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 150 MG/KG
11 - 300 MG/KG
12 - 600 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 196
Benzophenone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88138-01
C88138
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/04/1993
BC
119-61-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.125%
04 - 0.125%
05 - 0.25%
06 - 0.25%
07 - 0.5%
08 - 0.5%
09 - 1.0%
10 - 1.0%
11 - 2.0%
12 - 2.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 197
Benzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88138-02
C88138
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/07/1993
BC
119-61-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.125%
04 - 0.125%
05 - 0.25%
06 - 0.25%
07 - 0.5%
08 - 0.5%
09 - 1.0%
10 - 1.0%
11 - 2.0%
12 - 2.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 198
Benzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88138-03
C88138B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/16/1999
BC
119-61-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 199
Benzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88138-04
C88138B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/13/1999
BC
119-61-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 200
Benzyl acetate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05120-01
C06508B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/30/1985
SO
140-11-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTRTD CONTROL
02 - UNTRTD CONTROL
03 - 3130 PPM
04 - 3130 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 201
Benzyl acetate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05120-02
C06508B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/14/1985
SO
140-11-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 3130 PPM
04 - 3130 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 202
Benzyl acetate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05120-03
C06508B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/09/1986
SO
140-11-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.3%
04 - 0.3%
05 - 0.6%
06 - 0.6%
07 - 1.2%
08 - 1.2%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 203
Benzyl acetate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05120-04
C06508B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/25/1986
SO
140-11-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .033%
04 - .033%
05 - .1%
06 - .1%
07 - .3%
08 - .3%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 204
Benzyl acetate + glycine combination study
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
FEED
93017-01
C93017
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/18/1994
MB
GLYCINEBENZA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 20000 PPM BA
03 - 35000 PPM BA
04 - 50000 PPM BA
05 - 50000PPMBA-GLY
06 - 50000PPMBA-ALA
07 - ALANINE
V
T
T
T
T
T
T
M
M
M
M
M
M
M
NIH-07
Page 205
o-Benzyl-p-chlorophenol
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05086-01
C61201C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/28/1984
BC
120-32-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0MG/KG M
02 - 0MG/KG 13HUCC M
03 - 0MG/KG 65HUCC M
04 - 30MG/KG M
05 - 30MG/KG 13HUCC M
06 - 30MG/KG 65HUCC M
07 - 60MG/KG M
08 - 60MG/KG 13HUCC M
09 - 60MG/KG 65HUCC M
10 - 120MG/KG M
11 - 120MG/KG13HUCC M
12 - 120MG/KG65HUCC M
13 - 0MG/KG F
14 - 0MG/KG 13HUCC F
15 - 0MG/KG 65HUCC F
16 - 60MG/KG F
17 - 60MG/KG 13HUCC F
18 - 60MG/KG 65HUCC F
19 - 120MG/KG F
20 - 120MG/KG13HUCC F
21 - 120MG/KG65HUCC F
22 - 240MG/KG F
23 - 240MG/KG13HUCC F
24 - 240MG/KG65HUCC F
V
V
V
T
T
T
T
T
T
T
T
T
V
V
V
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
CORN OIL
Page 206
o-Benzyl-p-chlorophenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05086-02
C61201C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/28/1984
BC
120-32-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 120 MG/KG
03 - 240 MG/KG
04 - 480 MG/KG
05 - 0 MG/KG
06 - 120 MG/KG
07 - 240 MG/KG
08 - 480 MG/KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
CORN OIL
Page 207
o-Benzyl-p-chlorophenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
DERM SOL
05086-04
C61201B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, CD-1 CRL
03/25/1985
BC
120-32-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE/ DMBA
03 - DMBA/ VEHICLE
04 - DMBA/TPA
05 - DMBA/BCP .1MG
06 - DMBA/BCP1.0 MG
07 - DMBA/BCP3.0 MG
08 - TPA/TPA
09 - BCP/TPA
10 - BCP/.1MGCOMPLETE
11 - BCP/1 MGCOMPLETE
12 - BCP/3 MGCOMPLETE
13 - VEHICLE CONTROL
14 - VEHICLE/ DMBA
15 - DMBA/ VEHICLE
16 - DMBA/TPA
17 - DMBA/BCP .1MG
18 - DMBA/BCP1.0MG
19 - DMBA/BCP3.0MG
20 - TPA/TPA
21 - BCP/TPA
22 - BCP/.1MGCOMPLETE
23 - BCP/ 1MGCOMPLETE
24 - BCP/ 3MGCOMPLETE
V
I
T
P
T
T
T
T
T
T
T
T
V
T
T
P
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
ACETONE
Page 208
Benzyltrimethyl ammonium chloride
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88139-05
C88139C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/12/1993
MB
56-93-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 12.5 MG/KG
03 - 25.0 MG/KG
04 - 50.0 MG/KG
05 - 100.0 MG/KG
06 - CONTROL
07 - 12.5 MG/KG
08 - 25.0 MG/KG
09 - 50.0 MG/KG
10 - 100.0 MG/KG
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
F
F
F
F
F
DEIONIZED WATER
Page 209
Benzyltrimethyl ammonium chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88139-06
C88139C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/14/1993
MB
56-93-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 12.5 MG/KG
03 - 25.0 MG/KG
04 - 50.0 MG/KG
05 - 100.0 MG/KG
06 - CONTROL
07 - 12.5 MG/KG
08 - 25.0 MG/KG
09 - 50.0 MG/KG
10 - 100.0 MG/KG
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
F
F
F
F
F
DEIONIZED WATER
Page 210
2,2-bis(Bromomethyl)-1,3-propanediol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05103-01
C55516B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/22/1986
BS
3296-90-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 1250 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
09 - 10000PPM
10 - 10000PPM
11 - 20000PPM
12 - 20000PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 211
(UNSPECIFIED)
2,2-bis(Bromomethyl)-1,3-propanediol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05103-02
C55516B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/14/1986
BS
3296-90-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10000PPM
12 - 10000PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 212
(UNSPECIFIED)
2,2-bis(Bromomethyl)-1,3-propanediol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05103-03
C55516B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/12/1986
BS
3296-90-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 1250 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
09 - 10000PPM
10 - 10000PPM
11 - 20000PPM
12 - 20000PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 213
(UNSPECIFIED)
2,2-bis(Bromomethyl)-1,3-propanediol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05103-04
C55516C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/13/1989
SO
3296-90-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.0312%
04 - 0.0312%
05 - 0.0625%
06 - 0.0625%
07 - 0.125%
08 - 0.125%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 214
2,2-bis(Bromomethyl)-1,3-propanediol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05103-05
C55516C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/27/1989
SO
3296-90-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.25%
04 - 0.25%
05 - 0.50%
06 - 0.50%
07 - 1.00%
08 - 1.00%
09 - 2.00%
U
U
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
NIH-07
Page 215
Bisphenol A
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
10034-01
C10034
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprague Dawley (NCTR)
06/01/2010
NR
80-05-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
14 - F1 Vehicle Ctrl
15 - F1 Vehicle Ctrl
16 - F1 2.5 BPA
17 - F1 2.5 BPA
18 - F1 8 BPA
19 - F1 8 BPA
20 - F1 25 BPA
21 - F1 25 BPA
22 - F1 80 BPA
23 - F1 80 BPA
24 - F1 260 BPA
25 - F1 260 BPA
26 - F1 840 BPA
27 - F1 840 BPA
28 - F1 2700 BPA
29 - F1 2700 BPA
30 - F1 100,000 BPA
31 - F1 100,000 BPA
32 - F1 300,000 BPA
33 - F1 300,000 BPA
34 - F1 0.5 EE2
35 - F1 0.5 EE2
36 - F1 5.0 EE2
37 - F1 5.0 EE2
38 - F1 Naive Ctrl
39 - F1 Naive Ctrl
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
U
U
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.3% Carboxymethylcellulose
Page 216
UNTREATED
Bisphenol A (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
10034-02
C10034
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprague Dawley (NCTR)
01/13/2013
NR
80-05-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
08 - F1 Veh. Ctrl M
09 - F1 Veh. Ctrl F
10 - F1 2.5 BPA M
11 - F1 2.5 BPA F
12 - F1 25.0 BPA M
13 - F1 25.0 BPA F
14 - F1 250.0 BPA M
15 - F1 250.0 BPA F
16 - F1 2500.BPA M
17 - F1 2500.BPA F
18 - F1 25000 BPA M
19 - F1 25000 BPA F
20 - F1 0.05 EE2 M
21 - F1 0.05 EE2 F
22 - F1 0.50 EE2 M
23 - F1 0.50 EE2 F
24 - F1 Veh. StDose M
25 - F1 Veh. StDose F
26 - F1 2.5 StDose M
27 - F1 2.5 StDose F
28 - F1 25.0 StDose M
29 - F1 25.0 StDose F
30 - F1 250.0StDose M
31 - F1 250.0StDose F
32 - F1 2500.StDose M
33 - F1 2500.StDose F
34 - F1 25000StDose M
35 - F1 25000StDose F
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.3% Carboxymethylcellulose
Page 217
Bisphenol A (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
10034-03
C10034
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprague Dawley (NCTR)
01/14/2013
NR
80-05-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
08 - F1 Veh. Ctrl M
09 - F1 Veh. Ctrl F
10 - F1 2.5 BPA M
11 - F1 2.5 BPA F
12 - F1 25.0 BPA M
13 - F1 25.0 BPA F
14 - F1 250.0 BPA M
15 - F1 250.0BPA F
16 - F1 2500.BPA M
17 - F1 2500.BPA F
18 - F1 25000 BPA M
19 - F1 25000 BPA F
20 - F1 0.05 EE2 M
21 - F1 0.05 EE2 F
22 - F1 0.50 EE2 M
23 - F1 0.50 EE2 F
24 - F1 Veh.StDose M
25 - F1 Veh. StDose F
26 - F1 2.5 StDose M
27 - F1 2.5 StDose F
28 - F1 25.0 StDose M
29 - F1 25.0 StDose F
30 - F1 250.0StDose M
31 - F1 250.0StDose F
32 - F1 2500.StDose M
33 - F1 2500.StDose F
34 - F1 25000StDose M
35 - F1 25000StDose F
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.3% Carboxymethylcellulose
Page 218
Bisphenol A (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
10034-04
C10034
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprague Dawley (NCTR)
01/14/2013
NR
80-05-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
08 - F1 Veh. Ctrl M
09 - F1 Veh. Ctrl F
10 - F1 2.5 BPA M
11 - F1 2.5 BPA F
12 - F1 25.0 BPA M
13 - F1 25.0 BPA F
14 - F1 250.0BPA M
15 - F1 250.0BPA F
16 - F1 2500.BPA M
17 - F1 2500.BPA F
18 - F1 25000BPA M
19 - F1 25000BPA F
20 - F1 0.05 EE2 M
21 - F1 0.05 EE2 F
22 - F1 0.50 EE2 M
23 - F1 0.50 EE2 F
24 - F1 Veh. StDose M
25 - F1 Veh. StDose F
26 - F1 2.5 StDose M
27 - F1 2.5 StDose F
28 - F1 25.0 StDose M
29 - F1 25.0 StDose F
30 - F1 250.0StDose M
31 - F1 250.0StDose F
32 - F1 2500.StDose M
33 - F1 2500.StDose F
34 - F1 25000StDose M
35 - F1 25000StDose F
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.3% Carboxymethylcellulose
Page 219
Black Cohosh
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
GAVAGE
00058-01
C00058
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/12/2010
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 62.5 mg/kg
03 - 125 mg/kg
04 - 250 mg/kg
05 - 500 mg/kg
06 - 1000 mg/kg
V
T
T
T
T
T
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 220
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
00058-03
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/02/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg male
02 - 0 mg/kg female
03 - 75 mg/kg male
04 - 75 mg/kg female
05 - 250 mg/kg male
06 - 250 mg/kg female
07 - 750 mg/kg male
08 - 750 mg/kg female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 221
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
00058-04
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
04/09/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 30 mg/kg
03 - 100 mg/kg
04 - 300 mg/kg
05 - 1000 mg/kg
V
T
T
T
T
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 222
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-85
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/04/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg Malepup
02 - 75 mg/kg Malepup
03 - 250mg/kg Malepup
04 - 750mg/kgMalepup
V
T
T
T
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 223
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-86
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/04/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg Fpup
02 - 75 mg/kg Fpup
03 - 250mg/kg Fpup
04 - 750mg/kg Fpup
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 224
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-88
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/04/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg Lac
02 - 75 mg/kg Lac
03 - 250 mg/kg Lac
04 - 750 mg/kg Lac
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 225
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-89
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/13/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg Ges
02 - 75 mg/kg Ges
03 - 250 mg/kg Ges
04 - 750 mg/kg Ges
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 226
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-95
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/27/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg Fpup
02 - 100mg/kg Fpup
03 - 300mg/kg Fpup
04 - 1000mg/kg Fpup
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 227
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-96
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/27/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg Malepup
02 - 100mg/kg Malepup
03 - 300mg/kg Malepup
04 - 1000mg/kgMalepup
V
T
T
T
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 228
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-97
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/27/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg Lac
02 - 100 mg/kg Lac
03 - 300 mg/kg Lac
04 - 1000 mg/kg Lac
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 229
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
00058-98
C00058B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/05/2012
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg Ges
02 - 100 mg/kg Ges
03 - 300 mg/kg Ges
04 - 1000 mg/kg Ges
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 230
Black Cohosh (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
GAVAGE
20112-01
C20112
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
03/08/2008
BC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 15 mg/kg
03 - 125 mg/kg
04 - 250 mg/kg
05 - 500 mg/kg
06 - 1000 mg/kg
V
T
T
T
T
T
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 231
Black newsprint ink
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05194-03
C61869
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/24/1988
BC
EMTDP-75
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CLIPPED UNTREATE
02 - CLIPPED UNTREATE
03 - USP GRAD MIN OIL
04 - USP GRAD MIN OIL
05 - PRTG INK MIN OIL
06 - PRTG INK MIN OIL
07 - LTRPRESS
08 - LTRPRESS
09 - OFFSET
10 - OFFSET
U
U
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
UNTREATED
Page 232
MINERAL OIL
(UNSPECIFIED)
Black newsprint ink (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05194-04
C61869
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3H
06/14/1988
BC
EMTDP-75
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CLIPPED UNTREATE
02 - CLIPPED UNTREATE
03 - USP GRAD MIN OIL
04 - USP GRAD MIN OIL
05 - PRTG INK MIN OIL
06 - PRTG INK MIN OIL
07 - LTRPRESS MANUF A
08 - LTPPRESS MANUF A
09 - LTPPRESS MANUF B
10 - LTRPRESS MANUF B
11 - LTRPRESS MANUF C
12 - LTRPRESS MANUF C
13 - LTRPRESS MANUF D
14 - LTRPRESS MANUF D
15 - LTRPRESS MIXTURE
16 - LTRPRESS MIXTURE
17 - OFFSET MANUF E
18 - OFFSET MANUF E
19 - OFFSET MANUF F
20 - OFFSET MANUF F
21 - OFFSET MANUF G
22 - OFFSET MANUF G
23 - OFFSET MANUF H
24 - OFFSET MANUF H
25 - OFFSET MIXTURE
26 - OFFSET MIXTURE
U
U
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
UNTREATED
Page 233
MINERAL OIL
(UNSPECIFIED)
Bromobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05081-05
C55492D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/14/1984
BN
108-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 50MG/KG MALE
04 - 50MG/KG FEMALE
05 - 100MG/KG MALE
06 - 100MG/KG FEMALE
07 - 200MG/KG MALE
08 - 200MG/KG FEMALE
09 - 400MG/KG MALE
10 - 400MG/KG FEMALE
11 - 600MG/KG MALE
12 - 600MG/KG FEMALE
13 - CONTROL M-SPEC
14 - CONTROL F-SPEC
15 - 50MG/KG M-SPEC
16 - 50MG/KG F-SPEC
17 - 200MG/KG M-SPEC
18 - 200MG/KG F-SPEC
19 - 600MG/KG M-SPEC
20 - 600MG/KG F-SPEC
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 234
Bromobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05081-06
C55492D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/07/1984
BN
108-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 50MG/KG MALE
04 - 50MG/KG FEMALE
05 - 100MG/KG MALE
06 - 100MG/KG FEMALE
07 - 200MG/KG MALE
08 - 200MG/KG FEMALE
09 - 400MG/KG MALE
10 - 400MG/KG FEMALE
11 - 600MG/KG MALE
12 - 600MG/KG FEMALE
13 - CONTROL M-SPEC
14 - CONTROL F-SPEC
15 - 50MG/KG M-SPEC
16 - 50MG/KG F-SPEC
17 - 200MG/KG M-SPEC
18 - 200MG/KG F-SPEC
19 - 600MG/KG M-SPEC
20 - 600MG/KG F-SPEC
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 235
Bromobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05081-07
C55492C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/28/1985
BN
108-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 10 PPM MALE
04 - 10 PPM FEMALE
05 - 30 PPM MALE
06 - 30 PPM FEMALE
07 - 100 PPM MALE
08 - 100 PPM FEMALE
09 - 300 PPM MALE
10 - 300 PPM FEMALE
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIR
Page 236
Bromobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05081-08
C55492C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/30/1985
BN
108-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 10 PPM MALE
04 - 10 PPM FEMALE
05 - 30 PPM MALE
06 - 30 PPM FEMALE
07 - 100 PPM MALE
08 - 100 PPM FEMALE
09 - 300 PPM FEMALE
V
V
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
F
AIR
Page 237
Bromobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20410-01
C20410
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/07/2004
IL
108-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6 HRS
02 - 25 MG/KG 6 HRS
03 - 75 MG/KG 6 HRS
04 - 250 MG/KG 6 HRS
05 - 0 MG/KG 24 HRS
06 - 25 MG/KG 24 HRS
07 - 75 MG/KG 24 HRS
08 - 250 MG/KG 24 HRS
09 - 0 MG/KG 48 HRS
10 - 25 MG/KG 48 HRS
11 - 75 MG/KG 48 HRS
12 - 250 MG/KG 48 HRS
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
CORN OIL
Page 238
Bromodichloromethane
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
RESP BDY
99038-01
C99038
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/06/1999
CI
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0.5 PPM
03 - 3 PPM
04 - 10 PPM
05 - 15 PPM
U
T
T
T
T
M
M
M
M
M
AIR
Page 239
beta-Bromo-beta-nitrostyrene
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
60855-01
C60855
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/05/1991
MB
7166-19-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 0.037 G/KG
03 - 0.075 G/KG
04 - 0.150 G/KG
05 - 0.300 G/KG
06 - 0.600 G/KG
07 - CONTROL
08 - 0.037
09 - 0.075 G/KG
10 - 0.150 G/KG
11 - 0.300 G/KG
12 - 0.600 G/KG
13 - CONTROL
14 - 0.037 G/KG
15 - 0.075 G/KG
16 - 0.150
17 - 0.300 G/KG
18 - 0.600 G/KG
19 - CONTROL
20 - 0.037 G/KG
21 - 0.075 G/KG
22 - 0.150 G/KG
23 - 0.300 G/KG
24 - 0.600 G/KG
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 240
beta-Bromo-beta-nitrostyrene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
60855-02
C60855
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/12/1991
MB
7166-19-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 0.037 G/KG
03 - 0.075 G/KG
04 - 0.150 G/KG
05 - 0.300 G/KG
06 - 0.600 G/KG
07 - CONTROL
08 - 0.037 G/KG
09 - 0.075 G/KG
10 - 0.150 G/KG
11 - 0.300 G/KG
12 - 0.600 G/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 241
1-Bromopropane
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20011-01
C20011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/15/2002
BN
106-94-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 125 PPM
04 - 125 PPM
05 - 250 PPM
06 - 250 PPM
07 - 500 PPM
08 - 500 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 2000 PPM
12 - 2000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 242
1-Bromopropane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20011-02
C20011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/15/2002
BN
106-94-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 125 PPM
04 - 125 PPM
05 - 250 PPM
06 - 250 PPM
07 - 500 PPM
08 - 500 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 2000 PPM
12 - 2000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 243
1-Bromopropane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20011-03
C20011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/11/2002
BN
106-94-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 244
1-Bromopropane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20011-04
C20011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/11/2002
BN
106-94-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIR
Page 245
1-Bromopropane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20011-05
C20011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/14/2003
BN
106-94-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 125 PPM
04 - 125 PPM
05 - 250 PPM
06 - 250 PPM
07 - 500 PPM
08 - 500 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 246
1-Bromopropane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20011-06
C20011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/21/2003
BN
106-94-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 247
1,3-Butadiene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05134-01
C50602B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/23/1986
BN
106-99-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 200 PPM
04 - 200 PPM
05 - 625 PPM
06 - 625 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 6250 PPM
10 - 6250 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIR
Page 248
1,3-Butadiene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05134-02
C50602C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/23/1986
BN
106-99-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 6.25 PPM
04 - 6.25 PPM
05 - 20 PPM
06 - 20 PPM
07 - 62.5 PPM
08 - 62.5 PPM
09 - 200 PPM
10 - 200 PPM
11 - 625 PPM
12 - 625 PPM
13 - 200 PPM SE40
14 - 312 PPM SE52
15 - 625 PPM SE13
16 - 625 PPM SE 26
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
M
M
M
AIR
Page 249
1,3-Butadiene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05134-03
C50602D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/13/1986
NE
106-99-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 1000 PPM
04 - 1000 PPM
05 - 5000 PPM
06 - 5000 PPM
07 - 10,000 PPM
08 - 10,000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 250
Butanal oxime
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
88045-01
C88045
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/11/1995
BC
110-69-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
09 - 2500 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 251
Butanal oxime (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
88045-02
C88045
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/12/1995
BC
110-69-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
09 - 2500 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 252
Butanal oxime (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88045-03
C88045
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/15/1996
BC
110-69-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 253
Butanal oxime (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88045-04
C88045
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/17/1996
BC
110-69-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 254
Butanal oxime (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88045-05
C88045
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/15/1996
BC
110-69-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 255
2,3-Butanedione
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20725-01
C20725
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
07/28/2008
BN
431-03-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 6.25 ppm
04 - 6.25 ppm
05 - 12.5 ppm
06 - 12.5 ppm
07 - 25 ppm
08 - 25 ppm
09 - 50 ppm
10 - 50 ppm
11 - 100 ppm
12 - 100 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 256
2,3-Butanedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20725-02
C20725
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/28/2008
BN
431-03-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 6.25 ppm
04 - 6.25 ppm
05 - 12.5 ppm
06 - 12.5 ppm
07 - 25 ppm
08 - 25 ppm
09 - 50 ppm
10 - 50 ppm
11 - 100 ppm
12 - 100 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 257
2,3-Butanedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20725-03
C20725
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
08/17/2009
BN
431-03-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 12.5 ppm
04 - 12.5 ppm
05 - 25 ppm
06 - 25 ppm
07 - 50 ppm
08 - 50 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 258
2,3-Butanedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20725-04
C20725
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/31/2009
BN
431-03-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 12.5 ppm
04 - 12.5 ppm
05 - 25 ppm
06 - 25 ppm
07 - 50 ppm
08 - 50 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 259
2-Butoxyethanol (ethylene glycol monobutyl ether)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05197-03
C62077
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/14/1988
MA
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 750 PPM
04 - 750 PPM
05 - 1500 PPM
06 - 1500 PPM
07 - 3000 PPM
08 - 3000 PPM
09 - 4500 PPM
10 - 4500 PPM
11 - 6000 PPM
12 - 6000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 260
2-Butoxyethanol (ethylene glycol monobutyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05197-05
C62077
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/17/1988
MA
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1500 PPM
03 - 3000 PPM
04 - 6000 PPM
U
T
T
T
M
M
M
M
DEIONIZED WATER
Page 261
2-Butoxyethanol (ethylene glycol monobutyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05197-06
C62077C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/14/1988
MA
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM LEUKEMIA
03 - 3000 PPM
04 - 3000 PPMLEUKEMIA
05 - 6000 PPM
06 - 6000 PPMLEUKEMIA
U
P
T
T
T
T
M
M
M
M
M
M
DEIONIZED WATER
Page 262
2-Butoxyethanol (ethylene glycol monobutyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05197-07
C62077
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/21/1988
MA
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 750 PPM
04 - 750 PPM
05 - 1500 PPM
06 - 1500 PPM
07 - 3000 PPM
08 - 3000 PPM
09 - 4500 PPM
10 - 4500 PPM
11 - 6000 PPM
12 - 6000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 263
2-Butoxyethanol (ethylene glycol monobutyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05197-09
C62077D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/23/1992
BN
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31 PPM
04 - 31 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
09 - 250 PPM
10 - 250 PPM
11 - 500 PPM
12 - 500 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 264
2-Butoxyethanol (ethylene glycol monobutyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05197-10
C62077D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/23/1992
BN
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31 PPM
04 - 31 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
09 - 250 PPM
10 - 250 PPM
11 - 500 PPM
12 - 500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 265
2-Butoxyethanol (ethylene glycol monobutyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05197-11
C62077D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/23/1993
BN
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31.2 PPM
04 - 31.2 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 266
2-Butoxyethanol (ethylene glycol monobutyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05197-12
C62077D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/26/1993
BN
111-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 267
tert-Butyl alcohol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05142-01
C55367B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/02/1985
SO
75-65-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.25%
04 - 0.25%
05 - 0.5%
06 - 0.5%
07 - 1.0%
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 268
tert-Butyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05142-02
C55367B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/10/1985
SO
75-65-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.25%
04 - 0.25%
05 - 0.5%
06 - 0.5%
07 - 1.0%
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 269
tert-Butyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05142-03
C55367B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/12/1986
SO
75-65-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0.125%
04 - 0.25%
05 - 0.25%
06 - 0.50%
07 - 0.50%
08 - 1.00%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 270
tert-Butyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05142-04
C55367B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/19/1986
SO
75-65-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0.5%
04 - 0.5%
05 - 1.0%
06 - 1.0%
07 - 2.0%
08 - 2.0%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 271
tert-Butyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05142-05
C55367C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/25/1987
BC
75-65-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 135 PPM
04 - 135 PPM
05 - 270 PPM
06 - 270 PPM
07 - 540 PPM
08 - 540 PPM
09 - 1080 PPM
10 - 1080 PPM
11 - 2100 PPM
12 - 2100 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 272
tert-Butyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05142-06
C55367C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/04/1987
BC
75-65-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 135 PPM
04 - 135 PPM
05 - 270 PPM
06 - 270 PPM
07 - 540 PPM
08 - 540 PPM
09 - 1080 PPM
10 - 1080 PPM
11 - 2100 PPM
12 - 2100 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 273
BUTYLBENZYLPHTHALATE
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
FEED
05059-01
C10422E
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/24/1983
NE
85-68-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
10 - VEHICLE/CONTROL
11 - .625%
12 - 1.25%
13 - 2.5%
14 - 5%
V
T
T
T
T
M
M
M
M
M
NIH-07
Page 274
Butyl benzyl phthalate
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
05094-01
C54375B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/24/1984
HR
85-68-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.00% CONTROL
02 - 0.00% MT CONTROL
03 - 0.03% LOW
04 - 0.03% LOW MT
05 - 0.09% MED LOW
06 - 0.28% MED
07 - 0.28% MED MT
08 - 0.83% MED HIGH
09 - 2.5% HIGH
10 - 2.5% HIGH MT
U
U
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
NIH-07
Page 275
Butyl benzyl phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05094-02
C54375C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/26/1989
SO
85-68-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 0.3%
04 - 0.6%
05 - 0.6%
06 - 1.2%
07 - 1.2%
08 - 2.4%
09 - CONTROL FEED RTD
10 - CONTROL FEED RTD
U
U
T
T
T
T
T
T
U
U
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 276
Butyl benzyl phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05094-03
C54375C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/17/1989
SO
85-68-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 1.2%
04 - 2.4%
U
U
T
T
M
F
M
F
NIH-07
Page 277
p-tert-Butylcatechol
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
93011-01
C93011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/20/1995
MB
98-29-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 3125 PPM
03 - 6250 PPM
04 - 12500 PPM
05 - 25000 PPM
06 - 50000 PPM
07 - 0 PPM
08 - 3125 PPM
09 - 6250 PPM
10 - 12500 PPM
11 - 25000 PPM
12 - 50000 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NTP-2000
Page 278
p-tert-Butylcatechol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
93011-02
C93011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/21/1995
MB
98-29-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 3125 PPM
03 - 6250 PPM
04 - 12500 PPM
05 - 25000 PPM
06 - 50000 PPM
07 - 0 PPM
08 - 3125 PPM
09 - 6250 PPM
10 - 12500 PPM
11 - 25000 PPM
12 - 50000 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NTP-2000
Page 279
p-tert-Butylcatechol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93011-03
C93011B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/26/1996
BC
98-29-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 781 PPM
04 - 781 PPM
05 - 1562 PPM
06 - 1562 PPM
07 - 3125 PPM
08 - 3125 PPM
09 - 6250 PPM
10 - 6250 PPM
11 - 12,500 PPM
12 - 12,500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 280
p-tert-Butylcatechol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93011-04
C93011B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/05/1996
BC
98-29-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 781 PPM
04 - 781 PPM
05 - 1562 PPM
06 - 1562 PPM
07 - 3125 PPM
08 - 3125 PPM
09 - 6250 PPM
10 - 6250 PPM
11 - 12,500 PPM
12 - 12,500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 281
n-Butyl Glycidyl Ether
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20525-01
C20525
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
07/10/2006
BN
2426-08-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 282
n-Butyl Glycidyl Ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20525-02
C20525
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/10/2006
BN
2426-08-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 283
tert-Butyl hydroperoxide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20215-01
C20215B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/27/2004
BC
75-91-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 22 MG/KG
04 - 22 MG/KG
05 - 44 MG/KG
06 - 44 MG/KG
07 - 88 MG/KG
08 - 88 MG/KG
09 - 175 MG/KG
10 - 175 MG/KG
11 - 350 MG/KG
12 - 350 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 284
tert-Butyl hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20215-02
C20215B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/27/2004
BC
75-91-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 22 MG/KG
04 - 22 MG/KG
05 - 44 MG/KG
06 - 44 MG/KG
07 - 88 MG/KG
08 - 88 MG/KG
09 - 176 MG/KG
10 - 176 MG/KG
11 - 350 MG/KG
12 - 350 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 285
tert-Butyl hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
20215-03
C20215
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/04/2004
BC
75-91-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 22 MG/KG
04 - 22 MG/KG
05 - 44 MG/KG
06 - 44 MG/KG
07 - 88 MG/KG
08 - 88 MG/KG
09 - 175 MG/KG
10 - 175 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
50 % AQUEOUS ACETONE
Page 286
tert-Butyl hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
20215-04
C20215
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/04/2004
BC
75-91-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 22 MG/KG
04 - 22 MG/KG
05 - 44 MG/KG
06 - 44 MG/KG
07 - 88 MG/KG
08 - 88 MG/KG
09 - 176 MG/KG
10 - 176 MG/KG
11 - 352 MG/KG
12 - 352 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
50 % AQUEOUS ACETONE
Page 287
tert-Butyl hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
SKIN
20215-98
C20215
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/04/2004
BC
75-91-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 22 MG/KG
03 - 44 MG/KG
04 - 88 MG/KG
05 - 175 MG/KG
V
T
T
T
T
M
M
M
M
M
50 % AQUEOUS ACETONE
Page 288
tert-Butyl hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20215-99
C20215B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/27/2004
BC
75-91-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 22 MG/KG
03 - 44 MG/KG
04 - 88 MG/KG
05 - 175 MG/KG
06 - 350 MG/KG
V
T
T
T
T
T
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 289
t-Butylhydroquinone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05217-01
C62157
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/21/1988
SO
1948-33-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.25%
04 - 0.25%
05 - 0.5%
06 - 0.5%
07 - 1.0%
08 - 1.0%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 290
t-Butylhydroquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05217-02
C62157
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/05/1988
SO
1948-33-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.25%
04 - 0.25%
05 - 0.5%
06 - 0.5%
07 - 1.0%
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 291
t-Butylhydroquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05217-03
C62157
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/29/1990
SO
1948-33-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.125%
04 - 0.125%
05 - 0.25%
06 - 0.25%
07 - 0.5%
08 - 0.5%
09 - 0.0% RTD
10 - 0.0% RTD
U
U
T
T
T
T
T
T
U
U
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 292
t-Butylhydroquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05217-04
C62157
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/12/1990
SO
1948-33-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 0.5%
04 - 0.5%
U
U
T
T
M
F
M
F
NIH-07
Page 293
t-Butylhydroquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05217-05
C62157
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/29/1989
SO
1948-33-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 0.125%
04 - 0.125%
05 - 0.25%
06 - 0.25%
07 - 0.5%
08 - 0.5%
09 - SENTNEL
U
U
T
T
T
T
T
T
S
M
F
M
F
M
F
M
F
F
NIH-07
Page 294
NONE
tert-Butyl perbenzoate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05118-03
C61518
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/30/1987
BC
614-45-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 30 MG/KG
04 - 30 MG/KG
05 - 60 MG/KG
06 - 60 MG/KG
07 - 125 MG/KG
08 - 125 MG/KG
09 - 250 MG/KG
10 - 250 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 295
tert-Butyl perbenzoate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05118-04
C61518
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/06/1987
BC
614-45-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 30 MG/KG
04 - 30 MG/KG
05 - 60 MG/KG
06 - 60 MG/KG
07 - 125 MG/KG
08 - 125 MG/KG
09 - 250 MG/KG
10 - 250 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 296
Butyraldehyde
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05125-01
C56291B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/04/1985
HR
123-72-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG VM
02 - 0 G/KG VF
03 - 0.075 G/KG LM
04 - 0.075 G/KG LF
05 - 0.15 G/KG MLM
06 - 0.15 G/KG MLF
07 - 0.3 G/KG MM
08 - 0.3 G/KG MF
09 - 0.6 G/KG MHM
10 - 0.6 G/KG MHF
11 - 1.2 G/KG HM
12 - 1.2 G/KG HF
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 297
Butyraldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05125-02
C56291B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/04/1985
HR
123-72-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG VM
02 - 0 G/KG VF
03 - 0.075 G/KG LM
04 - 0.075 G/KG LF
05 - 0.15 G/KG MLM
06 - 0.15 G/KG MLF
07 - 0.3 G/KG MM
08 - 0.3 G/KG MF
09 - 0.6 G/KG MHM
10 - 0.6 G/KG MHF
11 - 1.2 G/KG HM
12 - 1.2 G/KG HF
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 298
gamma-Butyrolactone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05002-05
C55878
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/10/1981
SO
96-48-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 112 MG/KG
04 - 225 MG/KG
05 - 225 MG/KG
06 - 450 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 299
gamma-Butyrolactone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05002-06
C55878
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/03/1981
SO
96-48-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 262 MG/KG
04 - 262 MG/KG
05 - 525 MG/KG
06 - 525 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 300
Cadmium oxide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05213-03
C02551
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/14/1989
BN
1306-19-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - .025 MG/M3
04 - .025 MG/M3
05 - .05 MG/M3
06 - .05 MG/M3
07 - 0.1 MG/M3
08 - 0.1 MG/M3
09 - 0.25 MG/M3
10 - 0.25 MG/M3
11 - 1 MG/M3
12 - 1 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 301
Cadmium oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05213-04
C02551
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/16/1989
BN
1306-19-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.025 MG/M3
04 - 0.025 MG/M3
05 - 0.05 MG/M3
06 - 0.05 MG/M3
07 - 0.1 MG/M3
08 - 0.1 MG/M3
09 - 0.25 MG/M3
10 - 0.25 MG/M3
11 - 1 MG/M3
12 - 1 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 302
DL-Camphor
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
87003-01
C87003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/03/1997
BC
76-22-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 16 MG/KG
04 - 16 MG/KG
05 - 32 MG/KG
06 - 32 MG/KG
07 - 64 MG/KG
08 - 64 MG/KG
09 - 125 MG/KG
10 - 125 MG/KG
11 - 250 MG/KG
12 - 250 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 303
DL-Camphor (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
87003-02
C87003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/03/1997
BC
76-22-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 200 MG/KG
04 - 200 MG/KG
05 - 400 MG/KG
06 - 400 MG/KG
07 - 600 MG/KG
08 - 600 MG/KG
09 - 800 MG/KG
10 - 800 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 304
DL-Camphor (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
87003-03
C87003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/16/1998
BC
76-22-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 16 MG/KG
04 - 16 MG/KG
05 - 32 MG/KG
06 - 32 MG/KG
07 - 64 MG/KG
08 - 64 MG/KG
09 - 125 MG/KG
10 - 125 MG/KG
11 - 250 MG/KG
12 - 250 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 305
DL-Camphor (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
87003-04
C87003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/18/1998
BC
76-22-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 200 MG/KG
04 - 200 MG/KG
05 - 400 MG/KG
06 - 400 MG/KG
07 - 600 MG/KG
08 - 600 MG/KG
09 - 800 MG/KG
10 - 800 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 306
DL-Camphor (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
SKIN
87003-99
C87003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/16/1998
BC
76-22-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 16 MG/KG
04 - 16 MG/KG
05 - 32 MG/KG
06 - 32 MG/KG
07 - 64 MG/KG
08 - 64 MG/KG
09 - 125 MG/KG
10 - 125 MG/KG
11 - 250 MG/KG
12 - 250 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 307
Carbon tetrachloride
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20324-02
C20324
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/06/2004
IL
56-23-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0MG/KG 3HR
02 - 50MG/KG 3HR
03 - 750MG/KG3HR
04 - 2500MGKG3HR
05 - 0MG/KG 6HR
06 - 50MG/KG 6HR
07 - 750MG/KG6HR
08 - 2500MGKG6HR
09 - 0MG/KG 24HR
10 - 50MG/KG 24HR
11 - 750MG/KG24HR
12 - 2500MGKG24HR
13 - 0MG/KG 72HR
14 - 50MG/KG 72HR
15 - 750MG/KG72HR
16 - 2500MGKG72HR
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
CORN OIL
Page 308
Carbon tetrachloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20324-03
C20324
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/11/2004
IL
56-23-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG ETHYLCEL
02 - 0 MG/KG CORN OIL
03 - 750MG/KGCARB TET
04 - 1500MGKGCARB TET
05 - 1500MGKGACETAMIN
06 - 0MG/KG ETHYLCEL
07 - 0MG/KG CORN OIL
08 - 750MG/KGCARB TET
09 - 1500MGKGCARB TET
10 - 1500MGKGACETAMIN
11 - 0 MG/KG ETHYLCEL
12 - 0 MG/KG CORN OIL
13 - 750MG/KGCARB TET
14 - 1500MGKGCARB TET
15 - 1500MGKGACETAMIN
16 - 0 MG/KG ETHYLCEL
17 - 0 MG/KG CORN OIL
18 - 750MG/KGCARB TET
19 - 1500MGKGCARB TET
20 - 1500MGKGACETAMIN
V
V
T
T
T
V
V
T
T
T
V
V
T
T
T
V
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
ETHYLCELLULOSE
CORN OIL
Page 309
ETHYLCELLULOSE
CORN OIL
ETHYLCELLULOSE
CORN OIL
ETHYLCELLULOSE
CORN OIL
ETHYLCELLULOSE
Carisoprodol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05186-01
C56235B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/25/1987
MB
78-44-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 100 MG/KG
04 - 100 MG/KG
05 - 200 MG/KG
06 - 200 MG/KG
07 - 400 MG/KG
08 - 400 MG/KG
09 - 800 MG/KG
10 - 800 MG/KG
11 - 1600 MG/KG
12 - 1600 MG/KG
15 - 0 MG/KG SPEC
16 - 0 MG/KG SPEC
17 - 100 MG/KG SPEC
18 - 100 MG/KG SPEC
19 - 200 MG/KG SPEC
20 - 200 MG/KG SPEC
21 - 400 MG/KG SPEC
22 - 400 MG/KG SPEC
23 - 800 MG/KG SPEC
24 - 800 MG/KG SPEC
25 - 1600 MG/KG SPEC
26 - 1600 MG/KG SPEC
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 310
Carisoprodol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05186-02
C56235B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/06/1987
MB
78-44-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 75 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 150 MG/KG
07 - 300 MG/KG
08 - 300 MG/KG
09 - 600 MG/KG
10 - 600 MG/KG
11 - 1200 MG/KG
12 - 1200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 311
Carisoprodol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05186-03
C56235C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/27/1992
BC
78-44-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 100 MG/KG
04 - 100 MG/KG
05 - 200 MG/KG
06 - 200 MG/KG
07 - 400 MG/KG
08 - 400 MG/KG
09 - 800 MG/KG
10 - 800 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 312
Carisoprodol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05186-04
C56235C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/29/1992
BC
78-44-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 600 MG/KG
04 - 600 MG/KG
05 - 1200 MG/KG
06 - 1200 MG/KG
07 - 1600 MG/KG
08 - 1600 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 313
D-Carvone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05032-01
C55867A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/22/1982
IR
2244-16-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 187MG/KG
03 - 375MG/KG
05 - VEHICLE CONTROL
06 - 187MG/KG
07 - 375MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 314
D-Carvone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05032-02
C55867A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/29/1982
IR
2244-16-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 375 MG/KG
03 - 750 MG/KG
05 - VEHICLE CONTROL
06 - 375 MG/KG
07 - 750 MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 315
D-Carvone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05032-03
C55867B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/16/1983
IR
2244-16-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 50 MG/KG
03 - 100MG/KG
05 - VEHICLE CONTROL
06 - 50 MG/KG
07 - 100 MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 316
Castor oil
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05209-01
C55163B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/14/1988
MB
8001-79-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .62%
04 - .62%
05 - 1.25%
06 - 1.25%
07 - 2.5%
08 - 2.5%
09 - 5.0%
10 - 5.0%
11 - 10%
12 - 10%
15 - 0% SPECIAL
16 - 0% SPECIAL
17 - .62% SPECIAL
18 - .62% SPECIAL
19 - 1.25% SPECIAL
20 - 1.25% SPECIAL
21 - 2.5% SPECIAL
22 - 2.5% SPECIAL
23 - 5.0% SPECIAL
24 - 5.0% SPECIAL
25 - 10% SPECIAL
26 - 10% SPECIAL
U
U
T
T
T
T
T
T
T
T
T
T
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 317
Castor oil (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05209-02
C55163B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/15/1988
MB
8001-79-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .62%
04 - .62%
05 - 1.25%
06 - 1.25%
07 - 2.5%
08 - 2.5%
09 - 5.0%
10 - 5.0%
11 - 10%
12 - 10%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 318
Cedarwood oil
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
20316-01
C20316
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/15/2005
BC
8000-27-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATED
02 - UNTREATED
03 - 0 %
04 - 0 %
05 - 6.25 %
06 - 6.25 %
07 - 12.5 %
08 - 12.5 %
09 - 25 %
10 - 25 %
11 - 50 %
12 - 50 %
13 - 100 %
14 - 100 %
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 319
AQUEOUS ETHANOL (95%)
Cedarwood oil (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
20316-02
C20316
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/13/2005
BC
8000-27-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATED
02 - UNTREATED
03 - 0 %
04 - 0 %
05 - 6.25 %
06 - 6.25 %
07 - 12.5 %
08 - 12.5 %
09 - 25 %
10 - 25 %
11 - 50 %
12 - 50 %
13 - 100 %
14 - 100 %
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 320
AQUEOUS ETHANOL (95%)
Cell Phone Radiation: CDMA
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-02
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/11/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg (1900MHz)
04 - 4 W/kg (1900MHz)
05 - 6 W/kg (1900MHz)
06 - 6 W/kg (1900MHz)
07 - 8 W/kg (1900MHz)
08 - 8 W/kg (1900MHz)
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 321
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-04
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/09/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg (900MHz)
04 - 4 W/kg (900MHz)
05 - 6 W/kg (900MHz)
06 - 6 W/kg (900MHz)
07 - 8 W/kg (900MHz)
08 - 8 W/kg (900MHz)
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 322
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-06
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/06/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg (900MHz)
04 - 4 W/kg (900MHz)
05 - 6 W/kg (900MHz)
06 - 6 W/kg (900MHz)
07 - 8 W/kg (900MHz)
08 - 8 W/kg (900MHz)
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 323
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-08
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/03/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg 1900MHz
04 - 4 W/kg 1900MHz
05 - 6 W/kg 1900MHz
06 - 6 W/kg 1900MHz
07 - 8 W/kg 1900MHz
08 - 8 W/kg 1900MHz
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 324
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-10
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/01/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 4 W/kg (900MHz)
03 - 6 W/kg (900MHz)
04 - 8 W/kg (900MHz)
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 325
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
Whole Body Exposure
20105-12
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/06/2010
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 5 W/kg 1900MHz
04 - 5 W/kg 1900MHz
05 - 10 W/kg 1900MHz
06 - 10 W/kg 1900MHz
07 - 15 W/kg 1900MHz
08 - 15 W/kg 1900MHz
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 326
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
Whole Body Exposure
20105-14
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
12/09/2010
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(CDMA)PreC
02 - 0W/kg(CDMA)PreC
03 - 3W/kg(CDMA)PreC
04 - 3W/kg(CDMA)PreC
05 - 6W/kg(CDMA)PreC
06 - 6W/kg(CDMA)PreC
07 - 9W/kg(CDMA)PreC
08 - 9W/kg(CDMA)PreC
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 327
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
Whole Body Exposure
20105-56
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/16/2012
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0W/kg(CDMA)chr
02 - 0.0W/kg(CDMA)chr
03 - 1.5W/kg(CDMA)chr
04 - 1.5W/kg(CDMA)chr
05 - 3.0W/kg(CDMA)chr
06 - 3.0W/kg(CDMA)chr
07 - 6.0W/kg(CDMA)chr
08 - 6.0W/kg(CDMA)chr
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 328
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-62
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/25/2012
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0W/kg(CDMA)Lac
02 - 0.0W/kg(CDMA)Lac
03 - 1.5W/kg(CDMA)Lac
04 - 1.5W/kg(CDMA)Lac
05 - 3.0W/kg(CDMA)Lac
06 - 3.0W/kg(CDMA)Lac
07 - 6.0W/kg(CDMA)Lac
08 - 6.0W/kg(CDMA)Lac
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 329
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-66
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/25/2012
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0W/kg(CDMA)Lac
02 - 1.5W/kg(CDMA)Lac
03 - 3.0W/kg(CDMA)Lac
04 - 6.0W/kg(CDMA)Lac
V
T
T
T
F
F
F
F
AIR
Page 330
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-68
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/04/2012
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(CDMA)Ges
02 - 1.5W/kg(CDMA)Ges
03 - 3W/kg(CDMA)Ges
04 - 6W/kg(CDMA)Ges
V
T
T
T
F
F
F
F
AIR
Page 331
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
Whole Body Exposure
20105-75
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/18/2012
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 2.5 W/kg
04 - 2.5 W/kg
05 - 5 W/kg
06 - 5 W/kg
07 - 10 W/kg
08 - 10 W/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 332
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-80
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/17/2010
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(CDMA)Lac
02 - 3W/kg(CDMA)Lac
03 - 6W/kg(CDMA)Lac
04 - 9W/kg(CDMA)Lac
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 333
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-82
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/17/2010
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(CDMA)Lac
02 - 3W/kg(CDMA)Lac
03 - 6W/kg(CDMA)Lac
04 - 9W/kg(CDMA)Lac
V
T
T
T
M
M
M
M
AIR
(UNSPECIFIED)
Page 334
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-84
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/17/2010
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(CDMA)Lac
02 - 3W/kg(CDMA)Lac
03 - 6W/kg(CDMA)Lac
04 - 9W/kg(CDMA)Lac
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 335
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-86
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/01/2010
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(CDMA)Ges
02 - 3W/kg(CDMA)Ges
03 - 6W/kg(CDMA)Ges
04 - 9W/kg(CDMA)Ges
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 336
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-87
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/07/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 10 W/kg (900MHz)
03 - 12 W/kg (900MHz)
V
T
T
F
F
F
AIR
(UNSPECIFIED)
Page 337
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-89
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/17/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg 1900MHz
04 - 10 W/kg 1900MHz
05 - 12 W/kg 1900MHz
06 - 12 W/kg 1900MHz
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 338
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-91
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/20/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg 1900MHz
04 - 10 W/kg 1900MHz
05 - 12 W/kg 1900MHz
06 - 12 W/kg 1900MHz
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 339
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-93
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/20/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg (900MHz)
04 - 10 W/kg (900MHz)
05 - 12 W/kg (900MHz)
06 - 12 W/kg (900MHz)
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 340
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-96
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/22/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg (900MHz)
04 - 10 W/kg (900MHz)
05 - 12 W/kg (900MHz)
06 - 12 W/kg (900MHz)
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 341
(UNSPECIFIED)
Cell Phone Radiation: CDMA (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-98
C20105B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/13/2009
TR
CELLPRADCDMA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg 1900MHz
04 - 10 W/kg 1900MHz
05 - 12 W/kg 1900MHz
06 - 12 W/kg 1900MHz
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 342
(UNSPECIFIED)
Cell Phone Radiation: GSM
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-01
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/04/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg (1900MHz)
04 - 4 W/kg (1900MHz)
05 - 6 W/kg (1900MHz)
06 - 6 W/kg (1900MHz)
07 - 8 W/kg (1900MHz)
08 - 8 W/kg (1900MHz)
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 343
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-03
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/02/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg (900MHz)
04 - 4 W/kg (900MHz)
05 - 6 W/kg (900MHz)
06 - 6 W/kg (900MHz)
07 - 8 W/kg (900MHz)
08 - 8 W/kg (900MHz)
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 344
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-05
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/29/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg (900MHz)
04 - 4 W/kg (900MHz)
05 - 6 W/kg (900MHz)
06 - 6 W/kg (900MHz)
07 - 8 W/kg (900MHz)
08 - 8 W/kg (900MHz)
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 345
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-07
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/27/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 4 W/kg 1900MHz
04 - 4 W/kg 1900MHz
05 - 6 W/kg 1900MHz
06 - 6 W/kg 1900MHz
07 - 8 W/kg 1900MHz
08 - 8 W/kg 1900MHz
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 346
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-09
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/24/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 4 W/kg (900MHz)
03 - 6 W/kg (900MHz)
04 - 8 W/kg (900MHz)
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 347
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
Whole Body Exposure
20105-11
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/06/2010
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 5 W/kg 1900MHz
04 - 5 W/kg 1900MHz
05 - 10 W/kg 1900MHz
06 - 10 W/kg 1900MHz
07 - 15 W/kg 1900MHz
08 - 15 W/kg 1900MHz
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 348
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
Whole Body Exposure
20105-13
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
12/09/2010
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(GSM)PreC
02 - 0W/kg(GSM)PreC
03 - 3W/kg(GSM)PreC
04 - 3W/kg(GSM)PreC
05 - 6W/kg(GSM)PreC
06 - 6W/kg(GSM)PreC
07 - 9W/kg(GSM)PreC
08 - 9W/kg(GSM)PreC
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 349
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
Whole Body Exposure
20105-59
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/16/2012
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0W/kg(GSM)chr
02 - 0.0W/kg(GSM)chr
03 - 1.5W/kg(GSM)chr
04 - 1.5W/kg(GSM)chr
05 - 3.0W/kg(GSM)chr
06 - 3.0W/kg(GSM)chr
07 - 6.0W/kg(GSM)chr
08 - 6.0W/kg(GSM)chr
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 350
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-65
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/25/2012
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0W/kg(GSM)Lac
02 - 0.0W/kg(GSM)Lac
03 - 1.5W/kg(GSM)Lac
04 - 1.5W/kg(GSM)Lac
05 - 3.0W/kg(GSM)Lac
06 - 3.0W/kg(GSM)Lac
07 - 6.0W/kg(GSM)Lac
08 - 6.0W/kg(GSM)Lac
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 351
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-67
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/25/2012
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(GSM)Lac
02 - 1.5W/kg(GSM)Lac
03 - 3.0W/kg(GSM)Lac
04 - 6.0W/kg(GSM)Lac
V
T
T
T
F
F
F
F
AIR
Page 352
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-69
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/04/2012
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(GSM)Ges
02 - 1.5W/kg(GSM)Ges
03 - 3W/kg(GSM)Ges
04 - 6W/kg(GSM)Ges
V
T
T
T
F
F
F
F
AIR
Page 353
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
Whole Body Exposure
20105-78
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/18/2012
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 2.5 W/kg
04 - 2.5 W/kg
05 - 5 W/kg
06 - 5 W/kg
07 - 10 W/kg
08 - 10 W/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 354
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-79
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/17/2010
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(GSM)Lac
02 - 3W/kg(GSM)Lac
03 - 6W/kg(GSM)Lac
04 - 9W/kg(GSM)Lac
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 355
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-81
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/17/2010
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(GSM)Lac
02 - 3W/kg(GSM)Lac
03 - 6W/kg(GSM)Lac
04 - 9W/kg(GSM)Lac
V
T
T
T
M
M
M
M
AIR
(UNSPECIFIED)
Page 356
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-83
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/17/2010
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(GSM)Lac
02 - 3W/kg(GSM)Lac
03 - 6W/kg(GSM)Lac
04 - 9W/kg(GSM)Lac
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 357
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
Whole Body Exposure
20105-85
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/01/2010
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0W/kg(GSM)Ges
02 - 3W/kg(GSM)Ges
03 - 6W/kg(GSM)Ges
04 - 9W/kg(GSM)Ges
V
T
T
T
F
F
F
F
AIR
(UNSPECIFIED)
Page 358
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-88
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/14/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 10 W/kg (900MHz)
03 - 12 W/kg (900MHz)
V
T
T
F
F
F
AIR
(UNSPECIFIED)
Page 359
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-90
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/10/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg 1900MHz
04 - 10 W/kg 1900MHz
05 - 12 W/kg 1900MHz
06 - 12 W/kg 1900MHz
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 360
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-92
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/20/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 10 W/kg (900MHz)
V
T
F
F
AIR
Page 361
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-94
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/13/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg (900MHz)
05 - 12 W/kg (900MHz)
06 - 12 W/kg (900MHz)
V
V
T
T
T
M
F
M
M
F
AIR
Page 362
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-95
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/06/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg 1900MHz
04 - 10 W/kg 1900MHz
05 - 12 W/kg 1900MHz
06 - 12 W/kg 1900MHz
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 363
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-97
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/15/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg (900MHz)
04 - 10 W/kg (900MHz)
05 - 12 W/kg (900MHz)
06 - 12 W/kg (900MHz)
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 364
(UNSPECIFIED)
Cell Phone Radiation: GSM (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
Whole Body Exposure
20105-99
C20105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/18/2009
TR
CELLPRADGSM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 W/kg
02 - 0 W/kg
03 - 10 W/kg 1900MHz
04 - 10 W/kg 1900MHz
05 - 12 W/kg 1900MHz
06 - 12 W/kg 1900MHz
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 365
(UNSPECIFIED)
Chemical mixture - drinking water contaminants
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
05193-03
C62420
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/03/1988
BC
CHEMMIXH2O
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 25 PPM
04 - 25 PPM
05 - 75 PPM
06 - 75 PPM
07 - 224 PPM
08 - 224 PPM
09 - 748 PPM
10 - 748 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 366
Chemical mixture - drinking water contaminants (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
05193-04
C62420
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/26/1988
BC
CHEMMIXH2O
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 25 PPM
04 - 25 PPM
05 - 75 PPM
06 - 75 PPM
07 - 224 PPM
08 - 224 PPM
09 - 748 PPM
10 - 748 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 367
Chitosan
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
20226-01
C20226
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
08/31/2006
BC
9012-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 %
02 - 0 %
03 - 1 %
04 - 1 %
05 - 3 %
06 - 3 %
07 - 9 %
08 - 9 %
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIN93-M
Page 368
Chitosan (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
20226-99
C20226
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
08/29/2006
BC
9012-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 %
02 - 0 %
03 - 1 %
04 - 1 %
05 - 3 %
06 - 3 %
07 - 9 %
08 - 9 %
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIN93-M
Page 369
Chloraminated water
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05089-01
C91008
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/28/1985
SO
CHLORAMINEMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE 3 SSAC
03 - VEHICLE CONTROL
04 - VEHICLE 3 SSAC
05 - 0.0200% CHLORAMI
06 - 0.0200% 3 SSAC
07 - 0.0200% CHLORAMI
08 - 0.0200% 3 SSAC
09 - 0.0100% CHLORAMI
10 - 0.0100% 3 SSAC
11 - 0.0100% CHLORAMI
12 - 0.0100% 3 SSAC
13 - 0.00500%CHLORAMI
14 - 0.00500% 3 SSAC
15 - 0.00500%CHLORAMI
16 - 0.00500% 3 SSAC
17 - 0.0275% CHLORINE
18 - 0.0275% 3 SSAC
19 - 0.0275% CHLORINE
20 - 0.0275% 3 SSAC
21 - 0.0140% CHLORINE
22 - 0.0140% 3 SSAC
23 - 0.0140% CHLORINE
24 - 0.0140% 3 SSAC
25 - 0.00700%CHLORINE
26 - 0.00700% 3 SSAC
27 - 0.00700%CHLORINE
28 - 0.00700% 3 SSAC
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
WATER
Page 370
Chloraminated water (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05089-02
C91008
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/29/1984
SO
CHLORAMINEMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE 3 SSAC
03 - VEHICLE CONTROL
04 - VEHICLE 3 SSAC
05 - 0.0200% CHLORAMI
06 - 0.0200% 3 SSAC
07 - 0.0200% CHLORAMI
08 - 0.0200% 3 SSAC
09 - 0.0100% CHLORAMI
10 - 0.0100% 3 SSAC
11 - 0.0100% CHLORAMI
12 - 0.0100% 3 SSAC
13 - 0.00500%CHLORAMI
14 - 0.00500% 3 SSAC
15 - 0.00500%CHLORAMI
16 - 0.00500% 3 SSAC
17 - 0.0275% CHLORINE
18 - 0.0275% 3 SSAC
19 - 0.0275% CHLORINE
20 - 0.0275% 3 SSAC
21 - 0.0140% CHLORINE
22 - 0.0140% 3 SSAC
23 - 0.0140% CHLORINE
24 - 0.0140% 3 SSAC
25 - 0.00700%CHLORINE
26 - 0.00700% 3 SSAC
27 - 0.00700%CHLORINE
28 - 0.00700% 3 SSAC
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
WATER
Page 371
2-Chloroacetophenone (CN)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05097-01
C55107
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/29/1982
BN
532-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 1 MG/M3 MALE
04 - 1 MG/M3 FEMALE
05 - 2 MG/M3 MALE
06 - 2 MG/M3 FEMALE
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 372
2-Chloroacetophenone (CN) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05097-02
C55107
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/21/1982
BN
532-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 2 MG/M3 MALE
04 - 2 MG/M3 FEMALE
05 - 4 MG/M3 MALE
06 - 4 MG/M3 FEMALE
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 373
m-Chloroaniline
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
61529-01
C61529B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/16/1992
BC
108-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
13 - 0 MG/KG INTERIM
14 - 0 MG/KG INTERIM
15 - 10 MG/KGINTERIM
16 - 10 MG/KGINTERIM
17 - 20 MG/KGINTERIM
18 - 20 MG/KGINTERIM
19 - 40 MG/KGINTERIM
20 - 40 MG/KGINTERIM
21 - 80 MG/KGINTERIM
22 - 80 MG/KGINTERIM
23 - 160MG/KGINTERIM
24 - 160MG/KGINTERIM
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACIDIFIED WATER
Page 374
m-Chloroaniline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
61529-02
C61529B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/18/1992
BC
108-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACIDIFIED WATER
Page 375
o-Chloroaniline
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
91001-01
C91001
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/27/1992
BC
95-51-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
13 - 0 MG/KG INTERIM
14 - 0 MG/KG INTERIM
15 - 10 MG/KGINTERIM
16 - 10 MG/KGINTERIM
17 - 20 MG/KGINTERIM
18 - 20 MG/KGINTERIM
19 - 40 MG/KGINTERIM
20 - 40 MG/KGINTERIM
21 - 80 MG/KGINTERIM
22 - 80 MG/KGINTERIM
23 - 160MG/KGINTERIM
24 - 160MG/KGINTERIM
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACIDIFIED WATER
Page 376
o-Chloroaniline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
91001-02
C91001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/29/1992
BC
95-51-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160MG/KG
12 - 160MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACIDIFIED WATER
Page 377
p-Chloroaniline hydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05020-01
C02039B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/26/1982
BC
20265-96-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - VEHICLE
03 - 2 MG/KG
04 - 2 MG/KG
05 - 18 MG/KG
06 - 18 MG/KG
07 - 6 MG/KG
08 - 6 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 378
p-Chloroaniline hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05020-02
C02039B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/09/1982
BC
20265-96-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - VEHICLE
03 - 3 MG/KG
04 - 3 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
07 - 10 MG/KG
08 - 10 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 379
o-Chlorobenzalmalononitrile (CS)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05096-01
C55118
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/22/1982
BN
2698-41-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - .075 MG/M3
04 - .075 MG/M3
05 - 0.25 MG/M3
06 - 0.25 MG/M3
07 - 0.75 MG/M3
08 - 0.75 MG/M3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 380
o-Chlorobenzalmalononitrile (CS) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05096-02
C55118
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/29/1982
BN
2698-41-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.75 MG/M3
04 - 0.75 MG/M3
05 - 1.5 MG/ M3
06 - 1.5 MG/ M3
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 381
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone(MX)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
95012-01
C95012
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/27/1999
SO
77439-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 6.25 MG/L
04 - 6.25 MG/L
05 - 12.5 MG/L
06 - 12.5 MG/L
07 - 25 MG/L
08 - 25 MG/L
09 - 50 MG/L
10 - 50 MG/L
11 - 100 MG/L
12 - 100 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 382
Chloroethane
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05078-01
C06224
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/17/1982
BN
75-00-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 15000 PPM
03 - CONTROL
04 - 15000 PPM
U
T
U
T
M
M
F
F
AIR
Page 383
Chloroethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05078-02
C06224
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/17/1982
BN
75-00-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 15000 PPM
03 - CONTROL
04 - 15000 PPM
U
T
U
T
M
M
F
F
AIR
Page 384
bis(2-Chloroethoxy)methane
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99028-01
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/10/2001
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 200 MG/KG
12 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 385
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99028-02
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/10/2001
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 200 MG/KG
12 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 386
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99028-03
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/04/2002
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
07 - 200 MG/KG
08 - 200 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 387
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99028-04
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/06/2002
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
07 - 200 MG/KG
08 - 200 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 388
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
99028-05
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/16/2002
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 75 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 150 MG/KG
07 - 300 MG/KG
08 - 300 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 389
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
99028-06
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/02/2002
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 150 MG/KG
04 - 100 MG/KG
05 - 300 MG/KG
06 - 200 MG/KG
07 - 600 MG/KG
08 - 400 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 390
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
99028-07
C99028B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/17/2009
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 50 mg/kg
03 - 100 mg/kg
04 - 150 mg/kg
05 - 200 mg/kg
06 - 300 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
CORN OIL
Page 391
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
99028-08
C99028C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3H/HeJ
04/14/2010
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 150 mg/kg
03 - 200 mg/kg
04 - 300 mg/kg
V
T
T
T
M
M
M
M
CORN OIL
Page 392
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
99028-09
C99028C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1J
06/30/2010
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 150 mg/kg
03 - 200 mg/kg
04 - 300 mg/kg
V
T
T
T
M
M
M
M
CORN OIL
Page 393
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
99028-10
C99028C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
05/19/2010
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 150 mg/kg
03 - 200 mg/kg
04 - 300 mg/kg
V
T
T
T
M
M
M
M
CORN OIL
Page 394
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
99028-11
C99028C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3H/HeJ
05/24/2010
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 50 mg/kg
03 - 100 mg/kg
04 - 150 mg/kg
05 - 200 mg/kg
06 - 300 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
CORN OIL
Page 395
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
99028-12
C99028C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1J
05/24/2010
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 50 mg/kg
03 - 100 mg/kg
04 - 150 mg/kg
05 - 200 mg/kg
06 - 300 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
CORN OIL
Page 396
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
99028-13
C99028C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
05/24/2010
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 50 mg/kg
03 - 100 mg/kg
04 - 150 mg/kg
05 - 200 mg/kg
06 - 300 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
CORN OIL
Page 397
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99028-97
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/05/2003
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 400 MG/KG
04 - 400 MG/KG
05 - 600 MG/KG
06 - 600 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 398
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
SKIN
99028-98
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/16/2003
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 200 MG/KG
04 - 200 MG/KG
05 - 400 MG/KG
06 - 400 MG/KG
07 - 600 MG/KG
08 - 600 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 399
bis(2-Chloroethoxy)methane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99028-99
C99028
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/04/2002
BC
111-91-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
07 - 200 MG/KG
08 - 200 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 400
2-Chloronitrobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05207-03
C62248
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/17/1989
BN
88-73-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1.1 PPM
04 - 1.1 PPM
05 - 2.3 PPM
06 - 2.3 PPM
07 - 4.5 PPM
08 - 4.5 PPM
09 - 9 PPM
10 - 9 PPM
11 - 18 PPM
12 - 18 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 401
2-Chloronitrobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05207-04
C62248
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/18/1989
BN
88-73-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1.1 PPM
04 - 1.1 PPM
05 - 2.3 PPM
06 - 2.3 PPM
07 - 4.5 PPM
08 - 4.5 PPM
09 - 9 PPM
10 - 9 PPM
11 - 18 PPM
12 - 18 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 402
4-Chloronitrobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05208-03
C62259
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/24/1989
BN
100-00-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1.5 PPM
04 - 1.5 PPM
05 - 3.0 PPM
06 - 3.0 PPM
07 - 6.0 PPM
08 - 6.0 PPM
09 - 12 PPM
10 - 12 PPM
11 - 24 PPM
12 - 24 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 403
4-Chloronitrobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05208-04
C62259
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/25/1989
BN
100-00-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1.5 PPM
04 - 1.5 PPM
05 - 3.0 PPM
06 - 3.0 PPM
07 - 6.0 PPM
08 - 6.0 PPM
09 - 12 PPM
10 - 12 PPM
11 - 24 PPM
12 - 24 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 404
Chloroprene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05136-05
C50522
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/10/1987
BN
126-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 5 PPM
04 - 5 PPM
05 - 12 PPM
06 - 12 PPM
07 - 32 PPM
08 - 32 PPM
09 - 80 PPM
10 - 80 PPM
11 - 200 PPM
12 - 200 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 405
(UNSPECIFIED)
AIR
Chloroprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05136-06
C50522
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/12/1987
BN
126-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 5 PPM
04 - 5 PPM
05 - 12 PPM
06 - 12 PPM
07 - 32 PPM
08 - 32 PPM
09 - 80 PPM
10 - 80 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIR
Page 406
Chloroprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05136-07
C50522B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/20/1990
BN
126-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 12.8 PPM
04 - 12.8 PPM
05 - 32 PPM
06 - 32 PPM
07 - 80 PPM
08 - 80 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 407
Chloroprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05136-08
C50522B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/13/1990
BN
126-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 12.8 PPM
04 - 12.8 PPM
05 - 32 PPM
06 - 32 PPM
07 - 80 PPM
08 - 80 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 408
Chloroprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
RESP BDY
05136-09
C50522C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
06/17/1996
NE
126-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 80 PPM
03 - 12.8 PPM
04 - 02.0 PPM
U
T
T
T
F
F
F
F
AIR
Page 409
Chloroprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
RESP BDY
05136-10
C50522D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
06/17/1996
NE
126-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 80 PPM
03 - 12.8 PPM
04 - 02.0 PPM
U
T
T
T
F
F
F
F
AIR
Page 410
1-Chloro-2-propanol, technical
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05160-01
C61983A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/09/1987
SR
127-00-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE MALE
02 - VEHICLE FEMALE
03 - 33 PPM MALE
04 - 33 PPM FEMALE
05 - 100 PPM MALE
06 - 100 PPM FEMALE
07 - 330 PPM MALE
08 - 330 PPM FEMALE
09 - 1000 PPMMALE
10 - 1000 PPMFEMALE
11 - 3300 PPMMALE
12 - 3300 PPMFEMALE
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 411
1-Chloro-2-propanol, technical (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05160-02
C61983A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/02/1987
SR
127-00-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE MALE
02 - VEHICLE FEMALE
03 - 33 PPM MALE
04 - 33 PPM FEMALE
05 - 100 PPM MALE
06 - 100 PPM FEMALE
07 - 330 PPM MALE
08 - 330 PPM FEMALE
09 - 1000 PPMMALE
10 - 1000 PPMFEMALE
11 - 3300 PPMMALE
12 - 3300 PPMFEMALE
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 412
1-Chloro-2-propanol, technical (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05160-05
C61983C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/05/1991
MA
127-00-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 150 PPM
04 - 150 PPM
05 - 325 PPM
06 - 325 PPM
07 - 650 PPM
08 - 650 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 413
1-Chloro-2-propanol, technical (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05160-06
C61983C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/02/1991
MA
127-00-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 250 PPM
04 - 250 PPM
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 414
O-CHLOROPYRIDINE
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
05989-01
C05989
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/17/2001
BC
109-09-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 300 PPM
06 - 300 PPM
07 - 1000 PPM
08 - 1000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 415
O-CHLOROPYRIDINE (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
05989-02
C05989
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/17/2001
BC
109-09-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 300 PPM
06 - 300 PPM
07 - 1000 PPM
08 - 1000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 416
o-Chloropyridine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99002-01
C99002
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/19/2000
MB
109-09-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 417
o-Chloropyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99002-02
C99002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/20/2000
MB
109-09-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 418
o-Chloropyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
99002-03
C99002B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/28/2003
MB
109-09-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 10 PPM
03 - 30 PPM
04 - 100 PPM
05 - 300 PPM
06 - 1000 PPM
07 - VEHICLE CONTROL
08 - 10 PPM
09 - 30 PPM
10 - 100 PPM
11 - 300 PPM
12 - 1000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
WATER
Page 419
o-Chloropyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
99002-04
C99002B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/31/2003
MB
109-09-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 10 PPM
03 - 30 PPM
04 - 100 PPM
05 - 300 PPM
06 - 1000 PPM
07 - VEHICLE CONTROL
08 - 10 PPM
09 - 30 PPM
10 - 100 PPM
11 - 300 PPM
12 - 1000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
WATER
Page 420
p-Chloro-a,a,a-trifluorotoluene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
10472-01
C10472
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/26/2009
BN
98-56-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 125 ppm
04 - 125 ppm
05 - 250 ppm
06 - 250 ppm
07 - 500 ppm
08 - 500 ppm
09 - 1000 ppm
10 - 1000 ppm
11 - 2000 ppm
12 - 2000 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 421
p-Chloro-a,a,a-trifluorotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
10472-02
C10472
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/26/2009
BN
98-56-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 125 ppm
04 - 125 ppm
05 - 250 ppm
06 - 250 ppm
07 - 500 ppm
08 - 500 ppm
09 - 1000 ppm
10 - 1000 ppm
11 - 2000 ppm
12 - 2000 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 422
p-Chloro-a,a,a-trifluorotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
10472-03
C10472B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/17/2011
BN
98-56-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 100 ppm
04 - 100 ppm
05 - 300 ppm
06 - 300 ppm
07 - 1000 ppm
08 - 1000 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 423
p-Chloro-a,a,a-trifluorotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
10472-04
C10472B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/31/2011
BN
98-56-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 100 ppm
04 - 100 ppm
05 - 200 ppm
06 - 200 ppm
07 - 400 ppm
08 - 400 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 424
Chromium picolinate monohydrate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
99027-01
C99027
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/16/2001
SO
27882-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 80 PPM
04 - 80 PPM
05 - 240 PPM
06 - 240 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 10000 PPM
10 - 10000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 425
Chromium picolinate monohydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
99027-02
C99027
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/14/2001
SO
27882-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 80 PPM
04 - 80 PPM
05 - 240 PPM
06 - 240 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 10000 PPM
10 - 10000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 426
Chromium picolinate monohydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
99027-03
C99027
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/12/2002
SO
27882-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2000 PPM
04 - 2000 PPM
05 - 10000 PPM
06 - 10000 PPM
07 - 50000 PPM
08 - 50000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 427
Chromium picolinate monohydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
99027-04
C99027
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/29/2002
SO
27882-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2000 PPM
04 - 2000 PPM
05 - 10000 PPM
06 - 10000 PPM
07 - 50000 PPM
08 - 50000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 428
Chromium picolinate monohydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99027-98
C99027
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/09/2002
SO
27882-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 2000 PPM
03 - 10000 PPM
04 - 50000 PPM
U
T
T
T
F
F
F
F
NTP-2000
Page 429
Chromium picolinate monohydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99027-99
C99027
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/16/2002
SO
27882-76-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 2000 PPM
03 - 10000 PPM
04 - 50000 PPM
U
T
T
T
M
M
M
M
NTP-2000
Page 430
C.I. Acid Red 114
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05163-01
C61096
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/10/1983
HZ
6459-94-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.007
04 - 0.015
05 - 0.015
06 - 0.03
07 - 0.03
08 - 0.06
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 431
C.I. Direct Blue 15
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05169-01
C61290
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/28/1983
HZ
2429-74-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.063
04 - 0.063
05 - 0.125
06 - 0.125
07 - 0.25
08 - 0.25
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 432
C.I. Direct Blue 218
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05130-01
C60877B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/21/1985
MB
28407-37-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 1000 PPMLOW MALE
03 - 3000 PPMMID MALE
04 - 10000PPMHIGHMALE
06 - CONTROL FEMALE
07 - 1000 PPMLOW FEM
08 - 3000 PPMMID FEM
09 - 10000PPMHIGH FEM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 433
C.I. Direct Blue 218 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05130-02
C60877B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/13/1985
MB
28407-37-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 1000 PPMLOW MALE
03 - 3000 PPMMID MALE
04 - 10000PPMHIGHMALE
06 - CONTROL FEMALE
07 - 1000 PPMLOW FEM
08 - 3000 PPMMID FEM
09 - 10000PPMHIGH FEM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 434
C.I. Direct Blue 218 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05130-03
C60877B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/15/1986
MB
28407-37-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1000 PPM
04 - 1000 PPM
05 - 3000 PPM
06 - 3000 PPM
07 - 10000PPM
08 - 10000PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 435
Cigarette smoke (Airways Disease Project)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
RESP NAS
20708-01
C20708
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
09/17/2007
BN
CIGSMOKE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - 90 ug WTPM/L
V
T
M
M
AIR
Page 436
trans-Cinnamaldehyde
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
56111-01
C56111B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/04/1995
BC
14371-10-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 1.25%
06 - 1.25%
07 - 2.5%
08 - 2.5%
09 - 5.0%
10 - 5.0%
11 - 10.0%
12 - 10.0%
U
U
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 437
MICROCAPSULES, NTP-2000
NTP-2000
trans-Cinnamaldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
56111-02
C56111B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/02/1995
BC
14371-10-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 1.25%
06 - 1.25%
07 - 2.5%
08 - 2.5%
09 - 5.0%
10 - 5.0%
11 - 10.0%
12 - 10.0%
U
U
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 438
MICROCAPSULES, NTP-2000
trans-Cinnamaldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
56111-03
C56111B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/08/1997
BC
14371-10-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - .312%
06 - .312%
07 - .625%
08 - .625%
09 - 1.25%
10 - 1.25%
V
V
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 439
MICROCAPSULES, NTP-2000
trans-Cinnamaldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
56111-04
C56111B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/24/1997
BC
14371-10-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - .312%
06 - .312%
07 - .625%
08 - .625%
09 - 1.25%
10 - 1.25%
V
V
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 440
MICROCAPSULES, NTP-2000
C.I. Pigment Red 3
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05019-03
C60366
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/15/1983
SO
2425-85-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 2.5%
04 - 2.5%
05 - 1.25%
06 - 1.25%
07 - 0.6%
08 - 0.6%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 441
C.I. Pigment Red 3 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05019-04
C60366
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/12/1983
SO
2425-85-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 5.0%
04 - 5.0%
05 - 2.5%
06 - 2.5%
07 - 1.25%
08 - 1.25%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 442
C.I. Pigment Red 23
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05021-03
C60377
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/11/1983
SO
6471-49-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 5.0%
04 - 5.0%
05 - 2.5%
06 - 2.5%
07 - 1.0%
08 - 1.0%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 443
C.I. Pigment Red 23 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05021-04
C60377
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/14/1982
SO
6471-49-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 5.0%
04 - 5.0%
05 - 2.5%
06 - 2.5%
07 - 1.0%
08 - 1.0%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 444
Citral
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
56348-01
C56348A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/05/1995
BC
5392-40-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - UNTREAT CONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 3900 PPM
06 - 3900 PPM
07 - 7800 PPM
08 - 7800 PPM
09 - 15600 PPM
10 - 15600 PPM
11 - 31300 PPM
12 - 31300 PPM
U
U
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 445
MICROCAPSULES, NTP-2000
NTP-2000
Citral (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
56348-02
C56348A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/07/1995
BC
5392-40-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - UNTREAT CONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 3900 PPM
06 - 3900 PPM
07 - 7800 PPM
08 - 7800 PPM
09 - 15600 PPM
10 - 15600 PPM
11 - 31300 PPM
12 - 31300 PPM
U
U
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 446
MICROCAPSULES, NTP-2000
NTP-2000
Citral (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
56348-03
C56348A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/06/1996
BC
5392-40-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - UNTREAT CONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 4000 PPM
10 - 4000 PPM
U
U
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 447
MICROCAPSULES, NTP-2000
Citral (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
56348-04
C56348A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/19/1996
BC
5392-40-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - UNTREAT CONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
09 - 2000 PPM
10 - 2000 PPM
U
U
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 448
MICROCAPSULES, NTP-2000
Cobalt
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
60311-01
C60311
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/02/2004
BN
7440-48-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 2.5 MG/M3
04 - 2.5 MG/M3
05 - 5 MG/M3
06 - 5 MG/M3
07 - 10 MG/M3
08 - 10 MG/M3
09 - 20 MG/M3
10 - 20 MG/M3
11 - 40 MG/M3
12 - 40 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 449
Cobalt (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
60311-02
C60311
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/02/2004
BN
7440-48-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 2.5 MG/M3
04 - 2.5 MG/M3
05 - 5 MG/M3
06 - 5 MG/M3
07 - 10 MG/M3
08 - 10 MG/M3
09 - 20 MG/M3
10 - 20 MG/M3
11 - 40 MG/M3
12 - 40 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 450
Cobalt (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
60311-03
C60311
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/07/2005
BN
7440-48-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - control
03 - 0.625 MG/M3
04 - 0.625 MG/M3
05 - 1.25 MG/M3
06 - 1.25 MG/M3
07 - 2.5 MG/M3
08 - 2.5 MG/M3
09 - 5.0 MG/M3
10 - 5.0 MG/M3
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIR
Page 451
Cobalt (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
60311-04
C60311
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/07/2005
BN
7440-48-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - control
03 - 0.625 mg/m3
04 - 0.625 mg/m3
05 - 1.25 mg/m3
06 - 1.25 mg/m3
07 - 2.5 mg/m3
08 - 2.5 mg/m3
09 - 5 mg/m3
10 - 5 mg/m3
11 - 10 mg/m3
12 - 10 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 452
Cobalt (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
60311-05
C60311
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
05/08/2006
BN
7440-48-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 1.25 mg/m3
04 - 1.25 mg/m3
05 - 2.5 mg/m3
06 - 2.5 mg/m3
07 - 5.0 mg/m3
08 - 5.0 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 453
Cobalt (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
60311-06
C60311
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/15/2006
BN
7440-48-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - control
03 - 1.25 mg/m3
04 - 1.25 mg/m3
05 - 2.5 mg/m3
06 - 2.5 mg/m3
07 - 5.0 mg/m3
08 - 5.0 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 454
Cobalt sulfate heptahydrate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05156-03
C61530
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/21/1986
BN
10026-24-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - .3 MG/M3
04 - .3 MG/M3
05 - 1 MG/M3
06 - 1 MG/M3
07 - 3 MG/M3
08 - 3 MG/M3
09 - 10 MG/M3
10 - 10 MG/M3
11 - 30 MG/M3
12 - 30 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 455
Cobalt sulfate heptahydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05156-04
C61530
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/23/1986
BN
10026-24-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - .3 MG/M3
04 - .3 MG/M3
05 - 1 MG/M3
06 - 1 MG/M3
07 - 3 MG/M3
08 - 3 MG/M3
09 - 10 MG/M3
10 - 10 MG/M3
11 - 30 MG/M3
12 - 30 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 456
Cobalt sulfate heptahydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05156-05
C61530B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/30/1990
BN
10026-24-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.3 MG/M3
04 - 0.3 MG/M3
05 - 1.0 MG/M3
06 - 1.0 MG/M3
07 - 3.0 MG/M3
08 - 3.0 MG/M3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 457
Cobalt sulfate heptahydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05156-06
C61530B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/23/1990
BN
10026-24-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.3 MG/M3
04 - 0.3 MG/M3
05 - 1.0 MG/M3
06 - 1.0 MG/M3
07 - 3.0 MG/M3
08 - 3.0 MG/M3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 458
Coconut oil acid diethanolamine condensate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
55312-01
C55312B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/10/1992
BC
68603-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
11 - 400 MG/KG
12 - 400 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 459
Coconut oil acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
55312-02
C55312B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/12/1992
BC
68603-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
07 - 200 MG/KG
08 - 200 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 800 MG/KG
12 - 800 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 460
Coconut oil acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
55312-03
C55312B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/01/1993
BC
68603-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 461
Coconut oil acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
55312-04
C55312B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/20/1993
BC
68603-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 100 MG/KG
04 - 100 MG/KG
05 - 200 MG/KG
06 - 200 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 462
TRANSGENIC LECM (COCONUT OIL DIETHANOLAMINE)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
55312-06
C55312
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/11/1996
IL
68603-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 0 MG
03 - 2.5 MG
04 - 2.5 MG
05 - 5.0 MG
06 - 5.0 MG
07 - 7.5 MG
08 - 7.5 MG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 463
Codeine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05068-03
C61541A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/18/1984
MA
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM MALE
02 - 390 PPM MALE
03 - 781 PPM MALE
04 - 1562 PPMMALE
05 - 3125 PPMMALE
06 - 6250 PPMMALE
08 - O PPM FEMALE
09 - 390 PPM FEMALE
10 - 781 PPM FEMALE
11 - 1562 PPMFEMALE
12 - 3125 PPMFEMALE
13 - 6250 PPMFEMALE
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 464
Codeine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05068-04
C61541A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/08/1984
MA
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM MALE
02 - 390 PPM MALE
03 - 781 PPM MALE
04 - 1562 PPMMALE
05 - 3125 PPMMALE
06 - 6250 PPMMALE
08 - O PPM FEMALE
09 - 390 PPM FEMALE
10 - 781 PPM FEMALE
11 - 1562 PPMFEMALE
12 - 3125 PPMFEMALE
13 - 6250 PPMFEMALE
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 465
Codeine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05068-05
C61541B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/08/1988
MB
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 400 PPM
04 - 400 PPM
05 - 800 PPM
06 - 800 PPM
07 - 1600 PPM
08 - 1600 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 466
Codeine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05068-06
C61541B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/15/1987
MB
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 750 PPM
04 - 750 PPM
05 - 3000 PPM
06 - 3000 PPM
07 - 6000 PPM
08 - 6000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 467
Codeine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05068-07
C61541B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/11/1987
MB
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 400 PPM
04 - 400 PPM
05 - 800 PPM
06 - 800 PPM
07 - 1600 PPM
08 - 1600 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 468
Codeine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05068-08
C61541B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/09/1987
MB
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 750 PPM
04 - 750 PPM
05 - 3000 PPM
06 - 3000 PPM
07 - 6000 PPM
08 - 6000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 469
Codeine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05068-09
C61541C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/14/1989
MB
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 400 PPM
04 - 400 PPM
05 - 800 PPM
06 - 800 PPM
07 - 1600 PPM
08 - 1600 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 470
Codeine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05068-10
C61541C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/29/1989
MB
76-57-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 750 PPM
04 - 750 PPM
05 - 1500 PPM
06 - 1500 PPM
07 - 3000 PPM
08 - 3000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 471
Corn oil
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05143-01
C00577
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/01/1986
MA
8001-30-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ML/KG
02 - 2.5 ML/KG
03 - 5.0 ML/KG
04 - 10.0 ML/KG
05 - 10 ML/KG
U
T
T
T
V
M
M
M
M
M
NIH-07
(UNSPECIFIED)
Page 472
SALINE
Corn oil (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05147-01
C00577
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/03/1986
MA
8001-30-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - COOP AG
T
M
(UNSPECIFIED)
Page 473
Coumarin
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05090-01
C07103B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/06/1984
BS
91-64-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100MG/KG
08 - 100MG/KG
09 - 0 MG/KG 39 KILL
10 - 100MG/KG
11 - 100MG/KG 39 STOP
12 - 0 MG/KG 65 KILL
13 - 100MG/KG 65 KILL
14 - 100MG/KG 65 STOP
V
V
T
T
T
T
T
T
V
T
T
V
T
T
M
F
M
F
M
F
M
F
M
M
M
M
M
M
CORN OIL
Page 474
Coumarin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05090-02
C07103B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/08/1984
BS
91-64-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 50 MG/KG
03 - 100MG/KG
04 - 200MG/KG
05 - VEHICLE CONTROL
06 - 50 MG/KG
07 - 100MG/KG
08 - 200MG/KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
CORN OIL
Page 475
p-Cresidine
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
02982-04
C02982B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.M
10/23/1989
MA
120-71-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 476
p-Cresidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
02982-05
C02982B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
11/20/1989
MA
120-71-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 477
p-Cresidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
02982-06
C02982B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.SH
12/18/1989
MA
120-71-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 478
o-Cresol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05176-03
C62168
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/20/1987
MB
95-48-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .188%
04 - .188%
05 - .375%
06 - .375%
07 - .75%
08 - .75%
09 - 1.5%
10 - 1.5%
11 - 3.0%
12 - 3.0%
15 - 0% SPECIAL
16 - 0% SPECIAL
17 - .188% SPECIAL
18 - .188% SPECIAL
19 - .375% SPECIAL
20 - .375% SPECIAL
21 - .75% SPECIAL
22 - .75% SPECIAL
23 - 1.5% SPECIAL
24 - 1.5% SPECIAL
25 - 3.0% SPECIAL
26 - 3.0% SPECIAL
U
U
T
T
T
T
T
T
T
T
T
T
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 479
o-Cresol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05176-04
C62168
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/26/1987
MB
95-48-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .125%
04 - .125%
05 - .25%
06 - .25%
07 - .5%
08 - .5%
09 - 1.0%
10 - 1.0%
11 - 2.0%
12 - 2.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 480
Cresols
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05174-03
C62260
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/23/1987
MB
1319-77-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .188%
04 - .188%
05 - .375%
06 - .375%
07 - .75%
08 - .75%
09 - 1.5%
10 - 1.5%
11 - 3.0%
12 - 3.0%
15 - 0% SPECIAL
16 - 0% SPECIAL
17 - .188% SPECIAL
18 - .188% SPECIAL
19 - .375% SPECIAL
20 - .375% SPECIAL
21 - .75% SPECIAL
22 - .75% SPECIAL
23 - 1.5% SPECIAL
24 - 1.5% SPECIAL
25 - 3.0% SPECIAL
26 - 3.0% SPECIAL
U
U
T
T
T
T
T
T
T
T
T
T
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 481
Cresols (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05174-04
C62260
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/24/1987
MB
1319-77-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.0625%
04 - 0.0625%
05 - 0.125%
06 - 0.125%
07 - 0.25%
08 - 0.25%
09 - 0.5%
10 - 0.5%
11 - 1.0%
12 - 1.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 482
Cresols (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05174-05
C62260B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/05/2002
BC
1319-77-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1500 PPM
03 - 5000 PPM
04 - 15000 PPM
V
T
T
T
M
M
M
M
NTP 2000 (IRRADIATED)
Page 483
Cresols (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05174-06
C62260B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/20/2002
BC
1319-77-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 3000 PPM
04 - 10000 PPM
V
T
T
T
F
F
F
F
NTP 2000 (IRRADIATED)
Page 484
Crotonaldehyde
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05124-01
C56279B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/03/1985
HR
4170-30-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG VM
02 - 0 MG/KG VF
03 - 2.5 MG/KG LM
04 - 2.5 MG/KG LF
05 - 5.0 MG/KG MLM
06 - 5.0 MG/KG MLF
07 - 10.0 MG/KG MM
08 - 10.0 MG/KG MF
09 - 20.0 MG/KG MHM
10 - 20.0 MG/KG MHF
11 - 40.0 MG/KG HM
12 - 40.0 MG/KG HF
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 485
Crotonaldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05124-02
C56279B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/03/1985
HR
4170-30-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG VM
02 - 0 MG/KG VF
03 - 2.5 MG/KG LM
04 - 2.5 MG/KG LF
05 - 5.0 MG/KG MLM
06 - 5.0 MG/KG MLF
07 - 10.0 MG/KG MM
08 - 10.0 MG/KG MF
09 - 20.0 MG/KG MHM
10 - 20.0 MG/KG MHF
11 - 40.0 MG/KG HM
12 - 40.0 MG/KG HF
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 486
Cumene
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
96011-01
C96011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/24/2000
BN
98-82-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 250 PPM
04 - 250 PPM
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
09 - 2000 PPM
10 - 2000 PPM
11 - 4000 PPM
12 - 4000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 487
Cumene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
96011-02
C96011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/24/2000
BN
98-82-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 250 PPM
04 - 250 PPM
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
09 - 2000 PPM
10 - 2000 PPM
11 - 4000 PPM
12 - 4000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 488
Cumene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
96011-03
C96011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/24/2000
BN
98-82-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 489
Cumene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
96011-04
C96011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/24/2000
BN
98-82-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 490
Cumene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
96011-05
C96011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/04/2001
BN
98-82-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 250 PPM
04 - 250 PPM
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 491
Cumene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
96011-06
C96011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/11/2001
BN
98-82-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 125 PPM
04 - 250 PPM
05 - 250 PPM
06 - 500 PPM
07 - 500 PPM
08 - 1000 PPM
V
V
T
T
T
T
T
T
M
F
F
M
F
M
F
M
AIR
Page 492
Cumene hydroperoxide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99029-01
C99029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/11/2003
BC
80-15-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6.25 MG/KG
04 - 6.25 MG/KG
05 - 12.5 MG/KG
06 - 12.5 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
09 - 50 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 100 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 493
Cumene hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99029-02
C99029
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/11/2003
BC
80-15-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6.25 MG/KG
04 - 6.25 MG/KG
05 - 12.5 MG/KG
06 - 12.5 MK/KG
07 - 25 MG/KG
08 - 25 MG/KG
09 - 50 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 100 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 494
Cumene hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99029-03
C99029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/08/2004
BC
80-15-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 495
Cumene hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99029-04
C99029
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/10/2004
BC
80-15-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - .75 MG/KG
04 - .75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 496
Cumene hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99029-98
C99029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/08/2004
BC
80-15-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 3 MG/KG
03 - 12 MG/KG
V
T
T
M
M
M
AQUEOUS ETHANOL (95%)
Page 497
Cumene hydroperoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
99029-99
C99029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/11/2003
BC
80-15-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
V
T
T
T
T
T
M
M
M
M
M
M
AQUEOUS ETHANOL (95%)
Page 498
Cupric sulfate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05206-05
C62191B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/08/1989
BC
7758-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 0 PPM HUCC
04 - 0 PPM HUCC
05 - 500 PPM
06 - 500 PPM
07 - 500 PPM HUCC
08 - 500 PPM HUCC
09 - 1000 PPM
10 - 1000 PPM
11 - 1000 PPM HUCC
12 - 1000 PPM HUCC
13 - 2000 PPM
14 - 2000 PPM
15 - 2000 PPM HUCC
16 - 2000 PPM HUCC
17 - 4000 PPM
18 - 4000 PPM
19 - 4000 PPM HUCC
20 - 4000 PPM HUCC
21 - 8000 PPM
22 - 8000 PPM
23 - 8000 PPM HUCC
24 - 8000 PPM HUCC
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 499
Cupric sulfate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05206-06
C62191B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/15/1989
BC
7758-99-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1000 PPM
04 - 1000 PPM
05 - 2000 PPM
06 - 2000 PPM
07 - 4000 PPM
08 - 4000 PPM
09 - 8000 PPM
10 - 8000 PPM
11 - 16,000 PPM
12 - 16,000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 500
2-Cyclohexen-1-one
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
92007-01
C92007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/17/1997
NE
930-68-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 0PPM
03 - 10PPM
04 - 10PPM
05 - 5PPM
06 - 5PPM
07 - 2.5PPM
08 - 2.5PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 501
2-Cyclohexen-1-one (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
92007-02
C92007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/24/1997
NE
930-68-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 0PPM
03 - 10PPM
04 - 10PPM
05 - 5PPM
06 - 5PPM
07 - 2.5PPM
08 - 2.5PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 502
Cyclohexanone oxime
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88047-02
C88047
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/29/1991
MB
100-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 625 PPM
03 - 1250 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 10000 PPM
07 - CONTROL
08 - 625 PPM
09 - 1250 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 10000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 503
Cyclohexene oxide
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
SKIN
93012-01
C93012
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/15/1995
MB
286-20-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 3.75 MG/KG
03 - 7.50 MG/KG
04 - 15 MG/KG
05 - 30 MG/KG
06 - 60 MG/KG
07 - 0 MG/KG
08 - 3.75 MG/KG
09 - 7.50 MG/KG
10 - 15 MG/KG
11 - 30 MG/KG
12 - 60.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 504
Cyclohexene oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
SKIN
93012-02
C93012
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/16/1995
MB
286-20-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 3.75 MG/KG
03 - 7.50 MG/KG
04 - 15 MG/KG
05 - 30 MG/KG
06 - 60 MG/KG
07 - 0 MG/KG
08 - 3.75 MG/KG
09 - 7.50 MG/KG
10 - 15 MG/KG
11 - 30 MG/KG
12 - 60.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 505
Cyclohexene oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
93012-03
C93012B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/15/1995
MB
286-20-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - 0 MG/KG
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 506
Cyclohexene oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
93012-04
C93012B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/16/1995
MB
286-20-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - 0 MG/KG
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 507
Cyclohexene oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
93012-05
C93012C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/12/1995
MB
286-20-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 250 MG/KG
03 - 500 MG/KG
04 - 1000 MG/KG
05 - 1940 MG/KG
V
T
T
T
T
M
M
M
M
M
CORN OIL
Page 508
Cyclohexene oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
93012-06
C93012C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/12/1995
MB
286-20-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 250 MG/KG
03 - 500 MG/KG
04 - 1000 MG/KG
05 - 2000 MG/KG
V
T
T
T
T
F
F
F
F
F
CORN OIL
Page 509
D&C Yellow No. 11
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05128-03
C61789
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/28/1986
MA
8003-22-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 700 PPM
06 - 1700 PPH
07 - 5000 PPM
08 - 5000 PPM
09 - 17000 PPM
10 - 17000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 510
D&C Yellow No. 11 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05128-04
C61789
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/21/1986
MA
8003-22-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 1700 PPM
06 - 1700 PPM
07 - 5000 PPM
08 - 5000 PPM
09 - 17000 PPM
10 - 17000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 511
D&C Yellow No. 11 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05128-06
C61789B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/26/1990
SO
8003-22-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 0.05%
04 - 0.05%
05 - 0.17%
06 - 0.17%
07 - 0.5%
08 - 0.5%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 512
2,4-Decadienal
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
93022-01
C93022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/13/1995
MB
25152-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/KG
02 - 45.0 MG/KG
03 - 133.0 MG/KG
04 - 400.0 MG/KG
05 - 1200.0 MG/KG
06 - 3600.0 MG/KG
07 - 0.0 MG/KG
08 - 45.0 KG/KG
09 - 133.0 MG/KG
10 - 400.0 MG/KG
11 - 1200.0 MG/KG
12 - 3600.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 513
2,4-Decadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
93022-02
C93022
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/14/1995
MB
25152-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/KG
02 - 45.0 MG/KG
03 - 133.0 MG/KG
04 - 400.0 MG/KG
05 - 1200.0 MG/KG
06 - 3600.0 MG/KG
07 - 0.0 MG/KG
08 - 45.0 KG/KG
09 - 133.0 MG/KG
10 - 400.0 MG/KG
11 - 1200.0 MG/KG
12 - 3600.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 514
2,4-Decadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93022-03
C93022B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/29/1996
SO
25152-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 50 MG/KG/DY
04 - 50 MG/KG/DY
05 - 100 MG/KG/DY
06 - 100 MG/KG/DY
07 - 200 MG/KG/DY
08 - 200 MG/KG/DY
09 - 400 MG/KG/DY
10 - 400 MG/KG/DY
11 - 800 MG/KG/DY
12 - 800 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 515
2,4-Decadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93022-04
C93022B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/31/1996
SO
25152-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 50 MG/KG/DY
04 - 50 MG/KG/DY
05 - 100 MG/KG/DY
06 - 100 MG/KG/DY
07 - 200 MG/KG/DY
08 - 200 MG/KG/DY
09 - 400 MG/KG/DY
10 - 400 MG/KG/DY
11 - 800 MG/KG/DY
12 - 800 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 516
2,4-Decadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93022-05
C93022B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/29/1996
SO
25152-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 50 MG/KG/DY
04 - 50 MG/KG/DY
05 - 100 MG/KG/DY
06 - 100 MG/KG/DY
07 - 200 MG/KG/DY
08 - 200 MG/KG/DY
09 - 400 MG/KG/DY
10 - 400 MG/KG/DY
11 - 800 MG/KG/DY
12 - 800 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 517
Decalin
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
93026-01
C93026
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/13/1996
BN
91-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 518
Decalin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
93026-02
C93026
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/13/1996
BN
91-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 519
Decalin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
93026-03
C93026
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, NCI BLK RTR
05/13/1996
BN
91-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 25 PPM
03 - 50 PPM
04 - 100 PPM
05 - 200 PPM
06 - 400 PPM
U
T
T
T
T
T
M
M
M
M
M
M
AIR
Page 520
Decalin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
93026-04
C93026
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/16/1996
BN
91-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 521
Decalin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
93026-05
C93026
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/16/1996
BN
91-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 522
Decalin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
93026-06
C93026
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/28/1997
BN
91-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 100 PPM
06 - 100 PPM
07 - 400 PPM
08 - 400 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 523
Decalin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
93026-07
C93026
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/14/1997
BN
91-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 100 PPM
07 - 100 PPM
08 - 400 PPM
09 - 400 PPM
V
V
T
T
T
T
T
T
T
M
F
M
F
M
M
F
M
F
AIR
Page 524
4,4'-Diamino-2,2'-stilbenedisulfonic acid, disodium salt
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05706-01
C60162
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/15/1983
IR
7336-20-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 6250PPM MALE
03 - 12500PPMMALE
04 - CONTROL FEMALE
05 - 6250PPM FEMALE
06 - 12500PPMFEMALE
U
T
T
U
T
T
M
M
M
F
F
F
NIH-07
Page 525
4,4'-Diamino-2,2'-stilbenedisulfonic acid, disodium salt (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05706-02
C60162
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/25/1983
IR
7336-20-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 12500PPMMALE
03 - 25000PPMMALE
04 - CONTROL FEMALE
05 - 12500PPMFEMALE
06 - 25000PPMFEMALE
U
T
T
U
T
T
M
M
M
F
F
F
NIH-07
Page 526
2,4-Diaminophenol dihydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05043-01
C60026
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/23/1982
MA
137-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE 72 VM
02 - .0125 G/KG 72LM
03 - .025G/KG72HM
04 - VEHICLE 72VF
05 - .0125 G/KG 72LF
06 - .025G/KG 72HF
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 527
2,4-Diaminophenol dihydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05043-02
C60026
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/15/1982
MA
137-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE 72VM
02 - .019 G/KG 72LM
03 - .038 G/KG 72HM
04 - VEHICLE 72VF
05 - .019 G/KG 72LF
06 - .038 G/KG 72HF
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 528
Diazoaminobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
96002-01
C96002
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/29/1997
MB
136-35-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 12.5 MG/KG
03 - 25 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 200 MG/KG
07 - 0 MG/KG
08 - 12.5 MG/KG
09 - 25 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 200 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 529
Diazoaminobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
96002-02
C96002
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/30/1997
MB
136-35-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 12.5 MG/KG
03 - 25 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 200 MG/KG
07 - 0 MG/KG
08 - 12.5 MG/KG
09 - 25 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 200 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 530
1,2-Dibromo-2,4-dicyanobutane
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97003-01
C97003B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/20/1998
MB
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 37.5 MG/KG
03 - 75 MG/KG
04 - 150 MG/KG
05 - 300 MG/KG
06 - 600 MG/KG
07 - VEHICLE CONTROL
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 150 MG/KG
11 - 300 MG/KG
12 - 600 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 531
1,2-Dibromo-2,4-dicyanobutane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97003-02
C97003B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/21/1998
MB
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 75 MG/KG
03 - 150 MG/KG
04 - 300 MG/KG
05 - 600 MG/KG
06 - 1200 MG/KG
07 - VEHICLE CONTROL
08 - 75 MG/KG
09 - 150 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 1200 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 532
1,2-Dibromo-2,4-dicyanobutane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
97003-03
C97003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/03/1998
MB
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 37.5 MG/KG
03 - 75 MG/KG
04 - 150 MG/KG
05 - 300 MG/KG
06 - 600 MG/KG
07 - VEHICLE CONTROL
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 150 MG/KG
11 - 300 MG/KG
12 - 600 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.7 % AQUEOUS METHYLCELLULOSE
Page 533
1,2-Dibromo-2,4-dicyanobutane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
97003-04
C97003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/04/1998
MB
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 75 MG/KG
03 - 150 MG/KG
04 - 300 MG/KG
05 - 600 MG/KG
06 - 1200 MG/KG
07 - VEHICLE CONTROL
08 - 75 MG/KG
09 - 150 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 1200 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.7 % AQUEOUS METHYLCELLULOSE
Page 534
1,2-Dibromo-2,4-dicyanobutane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
97003-05
C97003C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/14/2000
MB
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.2 MG/KG
03 - 0.6 MG/KG
04 - 2.0 MG/KG
05 - 6.0 MG/KG
06 - 18.0 MG/KG
07 - VEHICLE CONTROL
08 - 0.2 MG/KG
09 - 0.6 MG/KG
10 - 2.0 MG/KG
11 - 6.0 MG/KG
12 - 18.0 MG/KG
13 - CONTROL SPECIAL
14 - 0.2MG/KGSPECIAL
15 - 0.6MG/KGSPECIAL
16 - 2.0MG/KGSPECIAL
17 - 6.0MG/KGSPECIAL
18 - 18MG/KG SPECIAL
19 - CONTROL SPECIAL
20 - 0.2MG/KGSPECIAL
21 - 0.6MG/KGSPECIAL
22 - 2.0MG/KGSPECIAL
23 - 6.0MG/KGSPECIAL
24 - 18MG/KG SPECIAL
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 535
1,2-Dibromo-2,4-dicyanobutane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
97003-06
C97003C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/17/2000
MB
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.2 MG/KG
03 - 0.6 MG/KG
04 - 2.0 MG/KG
05 - 6.0 MG/KG
06 - 18.0 MG/KG
07 - VEHICLE CONTROL
08 - 0.2 MG/KG
09 - 0.6 MG/KG
10 - 2.0 MG/KG
11 - 6.0 MG/KG
12 - 18.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 536
1,2-Dibromo-2,4-dicyanobutane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
97003-07
C97003D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/10/2002
BC
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 2 MG/KG
04 - 2 MG/KG
05 - 6 MG/KG
06 - 6 MG/KG
07 - 18 MG/KG
08 - 18 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 537
1,2-Dibromo-2,4-dicyanobutane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
97003-08
C97003D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/24/2002
BC
35691-65-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.6 MG/KG
04 - 0.6 MG/KG
05 - 2 MG/KG
06 - 2 MG/KG
07 - 6 MG/KG
08 - 6 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 538
Dibutyl Phthalate
TEST:
ROUTE:
TDMS #:
NTP #:
MATING TRIAL
FEED
05167-01
C62022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/11/1988
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1250 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 7500 PPM
06 - 10000 PPM
07 - 20000 PPM
08 - 0 PPM
09 - 500 PPM
10 - 1750 PPM
11 - 3500 PPM
12 - 7000 PPM
13 - 10500 PPM
14 - 14000 PPM
15 - 28000 PPM
16 - 0 PPM
17 - 0 PPM
18 - 1250 PPM
19 - 1250 PPM
20 - 2500 PPM
21 - 2500 PPM
22 - 5000 PPM
23 - 5000 PPM
24 - 7500 PPM
25 - 7500 PPM
26 - 10000 PPM
27 - 10000 PPM
V
T
T
T
T
T
T
V
P
P
P
P
P
P
P
V
V
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 539
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
MATING TRIAL
FEED
05167-02
C62022
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/20/1987
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1250 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 7500 PPM
06 - 10000 PPM
07 - 20000 PPM
08 - 0 PPM
09 - 0 PPM
10 - 1250 PPM
11 - 1250 PPM
12 - 2500 PPM
13 - 2500 PPM
14 - 5000 PPM
15 - 5000 PPM
16 - 7500 PPM
17 - 7500 PPM
18 - 10000 PPM
V
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
M
F
M
F
M
F
M
F
M
F
M
NIH-07
Page 540
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
MATING TRIAL
FEED
05167-03
C62022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/15/1987
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 300 PPM
03 - 1000 PPM
04 - 3000 PPM
05 - 10000 PPM
06 - 30000 PPM
07 - 0 PPM
08 - 420 PPM
09 - 1400 PPM
10 - 4200 PPM
11 - 14000 PPM
12 - 42000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
NIH-07
Page 541
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
05167-04
C62022
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/13/1989
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM DAMS
02 - 5,000 PPP DAMS
03 - 0 PPM PUPS
04 - 0 PPM PUPS
05 - 5,000 PPM PUPS
06 - 5,000 PPM PUPS
V
T
V
V
T
T
F
F
M
F
M
F
NIH-07
Page 542
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
05167-05
C62022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/02/1989
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM DAMS
02 - 10,000 PPM DAMS
03 - 0 PPM PUPS
04 - 0 PPM PUPS
05 - 10,000 PPM PUPS
06 - 10,000 PPM PUPS
V
T
V
V
T
T
F
F
M
F
M
F
NIH-07
Page 543
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90 DAY W/PN EXP
FEED
05167-07
C62022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/24/1989
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - MPD/ 0 PPM
04 - MPD/ 0 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
09 - 10,000 PPM
10 - 10,000 PPM
11 - 20,000 PPM
12 - 20,000 PPM
13 - 40,000 PPM
14 - 40,000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 544
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05167-08
C62022B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/16/1989
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1250 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
09 - 10,000 PPM
10 - 10,000 PPM
11 - 20,000 PPM
12 - 20,000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 545
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05167-09
C62022B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/31/1989
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
07 - 10,000 PPM
08 - 10,000 PPM
09 - 20,000 PPM
10 - 20,000 PPM
11 - 40,000 PPM
12 - 40,000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 546
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
FEED
10987-01
C10987
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/30/2010
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 0 ppm
03 - 300 ppm
04 - 300 ppm
05 - 1000 ppm
06 - 1000 ppm
07 - 3000 ppm
08 - 3000 ppm
09 - 10000 ppm
10 - 10000 ppm
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 547
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
10987-02
C10987
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
08/16/2010
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 0 ppm
03 - 1000 ppm
04 - 1000 ppm
05 - 3000 ppm
06 - 3000 ppm
07 - 10000 ppm
08 - 10000 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 548
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10987-96
C10987
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/09/2010
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm FemalePup
02 - 300ppm FemalePup
03 - 1000ppmFemalePup
04 - 3000ppmFemalePup
05 - 10000ppmFmalePup
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 549
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10987-97
C10987
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/09/2010
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm MalePup
02 - 300 ppm MalePup
03 - 1000 ppm MalePup
04 - 3000 ppm MalePup
05 - 10000ppm MalePup
V
T
T
T
T
M
M
M
M
M
NIH-07 (IRRADIATED)
Page 550
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10987-98
C10987
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/09/2010
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm DamLac
02 - 300 ppm DamLac
03 - 1000 ppm DamLac
04 - 3000 ppm DamLac
05 - 10000 ppm DamLac
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 551
Dibutyl Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10987-99
C10987
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/18/2010
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm DamGes
02 - 300 ppm DamGes
03 - 1000 ppm DamGes
04 - 3000 ppm DamGes
05 - 10000 ppm DamGes
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 552
1,2-Dichlorobenzene (o-dichlorobenzene)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20412-01
C20412
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/13/2004
IL
95-50-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6 HR
02 - 15 MG/KG 6 HR
03 - 150 MG/KG 6 HR
04 - 1500 MG/KG 6 HR
05 - 0 MG/KG 24 HR
06 - 15 MG/KG 24 HR
07 - 150 MG/KG 24 HR
08 - 1500 MG/KG 24 HR
09 - 0 MG/KG 48 HR
10 - 15 MG/KG 48 HR
11 - 150 MG/KG 48 HR
12 - 1500 MG/KG 48 HR
V
T
T
T
V
V
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
CORN OIL
Page 553
1,4-Dichlorobenzene (p-dichlorobenzene)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20411-01
C20411
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/16/2004
IL
106-46-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg 6Hour
02 - 15mg/kg 6Hour
03 - 150mg/kg 6Hour
04 - 1500mg/kg 6Hour
05 - 0 mg/kg 24Hour
06 - 15mg/kg 24Hour
07 - 150mg/kg 24Hour
08 - 1500mg/kg 24Hour
09 - 0 mg/kg 48Hour
10 - 15mg/kg 48Hour
11 - 150mg/kg 48Hour
12 - 1500mg/kg 48Hour
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
CORN OIL
Page 554
(UNSPECIFIED)
CORN OIL
5,6-Dichloro-2-benzothiazolamine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05154-01
C61712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/09/1986
MB
24072-75-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/G
02 - 0 MG/G
03 - 0.15 MG/G
04 - 0.15 MG/G
05 - 0.38 MG/G
06 - 0.38 MG/G
07 - 0.96 MG/G
08 - 0.96 MG/G
09 - 2.4 MG/G
10 - 2.4 MG/G
11 - 6.0 MG/G
12 - 6.0 MG/G
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 555
5,6-Dichloro-2-benzothiazolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05154-02
C61712
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/11/1986
MB
24072-75-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/G
02 - 0 MG/G
03 - 0.075 MG/G
04 - 0.075 MG/G
05 - 0.15 MG/G
06 - 0.15 MG/G
07 - 0.38 MG/G
08 - 0.38 MG/G
09 - 0.96 MG/G
10 - 0.96 MG/G
11 - 2.4 MG/G
12 - 2.4 MG/G
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 556
p,p'-Dichlorodiphenyl sulfone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88120-01
C88120
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/28/1993
BC
80-07-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 30 PPM
04 - 30 PPM
05 - 100 PPM
06 - 100 PPM
07 - 300 PPM
08 - 300 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 3000 PPM
12 - 3000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 557
p,p'-Dichlorodiphenyl sulfone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88120-02
C88120
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/25/1993
BC
80-07-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 30 PPM
04 - 30 PPM
05 - 100 PPM
06 - 100 PPM
07 - 300 PPM
08 - 300 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 3000 PPM
12 - 3000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 558
p,p'-Dichlorodiphenyl sulfone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88120-03
C88120B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/18/1995
BC
80-07-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 10 PPM
04 - 30 PPM
05 - 30 PPM
06 - 100 PPM
07 - 100 PPM
08 - 300 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 559
p,p'-Dichlorodiphenyl sulfone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88120-04
C88120B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/04/1996
BC
80-07-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 30 PPM
04 - 30 PPM
05 - 100 PPM
06 - 100 PPM
07 - 300 PPM
08 - 300 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 560
1,2-Dichloroethane
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05129-01
C00511C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/04/1985
MA
107-06-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 4000 PPM
10 - 4000 PPM
11 - 8000 PPM
12 - 8000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 561
1,2-Dichloroethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05129-02
C00511C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/21/1985
MA
107-06-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 4000 PPM
10 - 4000 PPM
11 - 8000 PPM
12 - 8000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 562
1,2-Dichloroethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05129-03
C00511B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/04/1986
MA
107-06-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 18 MG/KG
04 - 30 MG/KG
05 - 37 MG/KG
06 - 61 MG/KG
07 - 74 MG/KG
08 - 122 MG/KG
09 - 148 MG/KG
10 - 243 MG/KG
11 - 296 MG/KG
12 - 487 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
F
M
F
M
F
M
F
M
F
M
CORN OIL
Page 563
1,2-Dichloroethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05129-04
C00511D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/11/1985
MA
107-06-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 4000 PPM
10 - 4000 PPM
11 - 8000 PPM
12 - 8000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 564
1,2-Dichloroethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05129-05
C00511D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, OSBORNE-MEND
12/02/1985
MA
107-06-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 4000 PPM
10 - 4000 PPM
11 - 8000 PPM
12 - 8000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 565
trans-1,2-Dichloroethylene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
54591-09
C54591D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/13/1993
MB
156-60-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - VEHICLE CONTROL
03 - 3125 PPM
04 - 6250 PPM
05 - 12500 PPM
06 - 25000 PPM
07 - 50000 PPM
08 - UNTREAT CONTROL
09 - VEHICLE CONTROL
10 - 3125 PPM
11 - 6250 PPM
12 - 12500 PPM
13 - 25000 PPM
14 - 50000 PPM
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NIH-07
MICROCAPSULES, NIH-07
Page 566
NIH-07
MICROCAPSULES, NIH-07
trans-1,2-Dichloroethylene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
54591-10
C54591D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/11/1993
MB
156-60-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - VEHICLE CONTROL
03 - 3125 PPM
04 - 6250 PPM
05 - 12500 PPM
06 - 25000 PPM
07 - 50000 PPM
08 - UNTREAT CONTROL
09 - VEHICLE CONTROL
10 - 3125 PPM
11 - 6250 PPM
12 - 12500 PPM
13 - 25000 PPM
14 - 50000 PPM
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NIH-07
MICROCAPSULES, NIH-07
Page 567
NIH-07
MICROCAPSULES, NIH-07
2,4-Dichlorophenol
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05052-01
C55345
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/04/1981
BC
120-83-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 5000 PPM
06 - 10000 PPM
V
V
T
T
T
T
M
F
F
M
F
M
ACETONE
Page 568
2,4-Dichlorophenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05052-02
C55345
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/11/1981
BC
120-83-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5000 PPM
04 - 5000 PPM
05 - 10000 PPM
06 - 10000 PPM
V
V
T
T
T
T
M
F
M
F
M
F
ACETONE
Page 569
2,3-Dichloropropylene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05216-03
C61881
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/10/1989
BC
78-88-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5 PPM
04 - 5 PPM
05 - 10 PPM
06 - 10 PPM
07 - 20 PPM
08 - 20 PPM
09 - 40 PPM
10 - 40 PPM
11 - 80 PPM
12 - 80 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 570
2,3-Dichloropropylene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05216-04
C61881
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/10/1989
BC
78-88-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5 PPM
04 - 5 PPM
05 - 10 PPM
06 - 10 PPM
07 - 20 PPM
08 - 20 PPM
09 - 40 PPM
10 - 40 PPM
11 - 80 PPM
12 - 80 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 571
Dichlorvos
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05049-01
C00113B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/29/1981
SO
62-73-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 8.0 MG/KG
04 - 8.0 MG/KG
05 - 4.0 MG/KG
06 - 4.0 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 572
Dichlorvos (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05049-02
C00113B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/10/1981
SO
62-73-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 20.0 MG/KG
04 - 40.0 MG/KG
05 - 10.0 MG/KG
06 - 20.0 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 573
Dicyclohexylcarbodiimide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
93021-01
C93021
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/28/1994
MB
538-75-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0_MG/ML
02 - 2 MG/ML L
03 - 6 MG/ML
04 - 17_MG/ML
05 - 50_MG/ML
06 - 150 MG/ML
07 - 0_MG/ML
08 - 2_MG/ML
09 - 6_MG/ML
10 - 17_MG/MLMG/ML
11 - 50_MG/ML
12 - 150 MG/ML
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 574
Dicyclohexylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
93021-02
C93021
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/29/1994
MB
538-75-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/ML
02 - 2 MG/ML
03 - 6 MG/ML
04 - 17 MG/ML
05 - 50 MG/ML
06 - 150 MG/ML
07 - 0 MG/ML
08 - 2 MG/ML
09 - 6 MG/ML
10 - 17 MG/ML
11 - 50 MG/ML
12 - 150 MG/ML
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 575
Dicyclohexylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
93021-03
C93021
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/20/1994
MB
538-75-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.75 MG/KG
03 - 1.5 MG/KG
04 - 3.0 MG/KG
05 - 6.0 MG/KG
06 - 12.0 MG/KG
07 - 0 MG/KG
08 - 0.75 MG/KG
09 - 1.5 MG/KG
10 - 3.0 MG/KG
11 - 6.0 MG/KG
12 - 12.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 576
Dicyclohexylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
93021-04
C93021
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/22/1994
MB
538-75-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 1.5 MG/KG
03 - 3 MG/KG
04 - 6.0 MG/KG
05 - 12 MG/KG
06 - 24.0 MG/KG
07 - 0 MG/KG
08 - 1.5 MG/KG
09 - 3 MG/KG
10 - 6.0 MG/KG
11 - 12 MG/KG
12 - 24.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 577
Dicyclohexylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
SKIN
93021-05
C93021B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
06/15/1995
MB
538-75-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - .75 MG/KG
03 - 1.5 MG/KG
04 - 3 MG/KG
05 - 6 MG/KG
06 - 12 MG/KG
V
T
T
T
T
T
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 578
Dicyclohexylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
93021-06
C93021C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
01/05/1999
MB
538-75-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - 0.75 MG/KG
03 - 1.5 MG/KG
04 - 3.0 MG/KG
05 - 6.0 MG/KG
06 - 12.0 MG/KG
V
T
T
T
T
T
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 579
2',3'-Dideoxycytidine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88073-01
C88073
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/15/1989
SO
7481-89-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 125 MG/KG
04 - 125 MG/KG
05 - 250 MG/KG
06 - 250 MG/KG
07 - 500 MG/KG
08 - 500 MG/KG
09 - 1000 MG/KG
10 - 1000 MG/KG
11 - 2000 MG/KG
12 - 2000 MG/KG
13 - 0 MG/KG
14 - 0 MG/KG
15 - 250 MG/KG
16 - 250 MG/KG
17 - 1000 MG/KG
18 - 1000 MG/KG
19 - 2000 MG/KG
20 - 2000 MG/KG
21 - 0 MG/KG
22 - 250 MG/KG
23 - 1000 MG/KG
24 - 2000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
V
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 580
2',3'-Dideoxycytidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88073-02
C88073
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/01/1989
SO
7481-89-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 125 MG/KG
04 - 125 MG/KG
05 - 250 MG/KG
06 - 250 MG/KG
07 - 500 MG/KG
08 - 500 MG/KG
09 - 1000 MG/KG
10 - 1000 MG/KG
11 - 2000 MG/KG
12 - 2000 MG/KG
13 - 0 MG/KG
14 - 0 MG/KG
15 - 250 MG/KG
16 - 250 MG/KG
17 - 1000 MG/KG
18 - 1000 MG/KG
19 - 2000 MG/KG
20 - 2000 MG/KG
21 - 0 MG/KG
22 - 250 MG/KG
23 - 1000 MG/KG
24 - 2000 MG/KG
25 - 0 MG/KG
26 - 250 MG/KG
27 - 1000 MG/KG
28 - 2000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
V
T
T
T
U
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 581
2',3'-Dideoxycytidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88073-03
C88073B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/16/1992
SO
7481-89-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 500 MG/KG
03 - 1000 MG/KG
V
T
T
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 582
2',3'-Dideoxycytidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
88073-04
C88073C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/08/1993
SO
7481-89-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - VEHICLE
03 - 500 MG/KG/DY
04 - 500 MG/KG/DY
05 - 1000 MG/KG/DY
06 - 1000 MG/KG/DY
07 - 1000 MG/KG/DY
08 - 1000 MG/KG/DY
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 583
2',3'-Dideoxycytidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
88073-05
C88073C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS
10/11/1993
SO
7481-89-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - VEHICLE
03 - 500 MG/KG/DY
04 - 500 MG/KG/DY
05 - 1000 MG/KG/DY
06 - 1000 MG/KG/DY
07 - 1000 MG/KG/DY
08 - 1000 MG/KG/DY
09 - 1000 MG/KG/DY
10 - 1000 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 584
2',3'-Dideoxyinosine (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88074-01
C88074
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/29/1990
SO
69655-05-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 100 MG/KG
04 - 100 MG/KG
05 - 250 MG/KG
06 - 250 MG/KG
07 - 500 MG/KG
08 - 500 MG/KG
09 - 1000 MG/KG
10 - 1000 MG/KG
11 - 2000 MG/KG
12 - 2000 MG/KG
13 - 0 MG/KG
14 - 0 MG/KG
15 - 100 MG/KG
16 - 100 MG/KG
17 - 500 MG/KG
18 - 500 MG/KG
19 - 2000 MG/KG
20 - 2000 MG/KG
21 - 0 MG/KG
22 - 0 MG/KG
23 - 100 MG/KG
24 - 100 MG/KG
25 - 250 MG/KG
26 - 250 MG/KG
27 - 500 MG/KG
28 - 500 MG/KG
29 - 1000 MG/KG
30 - 1000 MG/KG
31 - 2000 MG/KG
32 - 2000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 585
Diethanolamine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05162-05
C55174B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/05/1987
BC
111-42-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 32 MG/KG
04 - 32 MG/KG
05 - 63 MG/KG
06 - 63 MG/KG
07 - 125 MG/KG
08 - 125 MG/KG
09 - 250 MG/KG
10 - 250 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 586
Diethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05162-06
C55174B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/12/1987
BC
111-42-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 80 MG/KG
04 - 80 MG/KG
05 - 160 MG/KG
06 - 160 MG/KG
07 - 320 MG/KG
08 - 320 MG/KG
09 - 630 MG/KG
10 - 630 MG/KG
11 - 1250 MG/KG
12 - 1250 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 587
Diethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05162-07
C55174C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/26/1987
BC
111-42-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/ML
02 - 0 MG/ML
03 - .32 MG/ML
04 - .16 MG/ML
05 - .63 MG/ML
06 - .32 MG/ML
07 - 1.25 MG/ML
08 - .63 MG/ML
09 - 2.5 MG/ML
10 - 1.25 MG/ML
11 - 5.0 MG/ML
12 - 2.5 MG/ML
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 588
Diethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05162-08
C55174C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/20/1987
BC
111-42-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/ML
02 - 0 MG/ML
03 - .63 MG/ML
04 - .63 MG/ML
05 - 1.25 MG/ML
06 - 1.25 MG/ML
07 - 2.5 MG/ML
08 - 2.5 MG/ML
09 - 5.0 MG/ML
10 - 5.0 MG/ML
11 - 10.0 MG/ML
12 - 10.0 MG/ML
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 589
Diethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05162-09
C55174D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/08/1990
BC
111-42-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 16 MG/KG
04 - 8 MG/KG
05 - 32 MG/KG
06 - 16 MG/KG
07 - 64 MG/KG
08 - 32 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 590
Diethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05162-10
C55174D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/22/1990
BC
111-42-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 40 MG/KG
04 - 40 MG/KG
05 - 80 MG/KG
06 - 80 MG/KG
07 - 160 MG/KG
08 - 160 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 591
Diethylamine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
99017-01
C99017
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/12/2002
BN
109-89-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31 PPM
04 - 31 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
09 - 250 PPM
10 - 250 PPM
11 - 500 PPM
12 - 500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 592
Diethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
99017-02
C99017
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/12/2002
BN
109-89-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31 PPM
04 - 31 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
09 - 250 PPM
10 - 250 PPM
11 - 500 PPM
12 - 500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 593
Diethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
99017-03
C99017
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/16/2002
BN
109-89-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 8 PPM
04 - 8 PPM
05 - 16 PPM
06 - 16 PPM
07 - 32 PPM
08 - 32 PPM
09 - 62 PPM
10 - 62 PPM
11 - 125 PPM
12 - 125 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 594
Diethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
99017-04
C99017
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/16/2002
BN
109-89-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 8 PPM
04 - 8 PPM
05 - 16 PPM
06 - 16 PPM
07 - 32 PPM
08 - 32 PPM
09 - 62 PPM
10 - 62 PPM
11 - 125 PPM
12 - 125 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 595
Diethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
99017-05
C99017
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/25/2003
BN
109-89-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31 PPM
04 - 31 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 596
Diethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
99017-06
C99017
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/18/2003
BN
109-89-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 16 PPM
04 - 16 PPM
05 - 31 PPM
06 - 31 PPM
07 - 62.5 PPM
08 - 62.5 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 597
Di(2-ethylhexyl) Phthalate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
10188-01
C10188B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/17/2011
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm Male
02 - 0 ppm Female
03 - 300 ppm Male
04 - 300 ppm Female
05 - 1000 ppm Male
06 - 1000 ppm Female
07 - 3000 ppm Male
08 - 3000 ppm Female
09 - 10000 ppm Male
10 - 10000 ppm Female
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 598
Di(2-ethylhexyl) Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
10188-02
C10188
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/27/2011
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm Male
02 - 0 ppm Female
03 - 300 ppm Male
04 - 300 ppm Female
05 - 1000 ppm Male
06 - 1000 ppm Female
07 - 3000 ppm Male
08 - 3000 ppm Female
09 - 10000 ppm Male
10 - 10000 ppm Female
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 599
Di(2-ethylhexyl) Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10188-96
C10188
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/06/2011
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm FemalePup
02 - 300ppm FemalePup
03 - 1000ppmFemalePup
04 - 3000ppmFemalePup
05 - 10000ppmFmalePup
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 600
Di(2-ethylhexyl) Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10188-97
C10188
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/06/2011
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm MalePup
02 - 300ppm MalePup
03 - 1000ppm MalePup
04 - 3000ppm MalePup
05 - 10000ppm MalePup
V
T
T
T
T
M
M
M
M
M
NIH-07 (IRRADIATED)
Page 601
Di(2-ethylhexyl) Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10188-98
C10188
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/06/2011
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm DamLac
02 - 300 ppm DamLac
03 - 1000 ppm DamLac
04 - 3000 ppm DamLac
05 - 10000 ppm DamLac
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 602
Di(2-ethylhexyl) Phthalate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10188-99
C10188
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/15/2011
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm DamGes
02 - 300 ppm DamGes
03 - 1000 ppm DamGes
04 - 3000 ppm DamGes
05 - 10000 ppm DamGes
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 603
Diethyl phthalate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05106-01
C60048B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/06/1985
HR
84-66-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UL/RAT UM
02 - 0 UL/RAT UF
03 - 100 UL RAT LM
04 - 100 UL RAT LF
05 - 300 UL RAT HM
06 - 300 UL RAT HF
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 604
(UNSPECIFIED)
DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05106-02
C10112F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/31/1985
HR
84-66-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UL/MOUSE UM
02 - 0 UL/MOUSE UF
03 - 35 UL/MOUSE LM
04 - 35 UL/MOUSE LF
05 - 100 UL/MOUSE HM
06 - 100 UL/MOUSE HF
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 605
(UNSPECIFIED)
Diethyl phthalate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05106-03
C60048B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/23/1986
HR
84-66-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MICROLITERS
02 - 0 MICROLITERS
03 - 7.5 MICROLITERS
04 - 7.5 MICROLITERS
05 - 15 MICROLITERS
06 - 15 MICROLITERS
07 - 30 MICROLITERS
08 - 30 MICROLITERS
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 606
Diethyl phthalate/dimethyl phthalate
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05119-01
C55914
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, CD-1 CRL
07/28/1985
HR
DIETH/DIMETH
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - DMBA/TPA
02 - DMBA/ACETONE
03 - ACETONE/TPA
04 - DEP/TPA
05 - DEP/ACETONE
06 - DMBA/DEP
07 - ACETONE/DEP
08 - DMP/TPA
09 - DMP/ACETONE
10 - DMBA/DMP
11 - ACETONE/DMP
12 - ACETONE/ACETONE
P
T
T
T
T
T
T
T
T
T
T
V
M
M
M
M
M
M
M
M
M
M
M
M
ACETONE
Page 607
3,4-Dihydrocoumarin
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05091-01
C55890B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/02/1984
BS
119-84-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 150MG/KG
04 - 150MG/KG
05 - 300MG/KG
06 - 300MG/KG
07 - 600MG/KG
08 - 600MG/KG
09 - 0 MG/KG 39 KILL
10 - 600MG/KG 39 KILL
11 - 600MG/KG 41 STOP
12 - 0 MG/KG 65 KILL
13 - 600MG/KG 65 KILL
14 - 600MG/KG 65 STOP
V
V
T
T
T
T
T
T
V
T
T
V
T
T
M
F
M
F
M
F
M
F
M
M
M
M
M
M
CORN OIL
Page 608
3,4-Dihydrocoumarin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05091-02
C55890B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/18/1984
BS
119-84-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 200MG/KG
03 - 400MG/KG
04 - 800MG/KG
05 - VEHICLE CONTROL
06 - 200MG/KG
07 - 400MG/KG
08 - 800MG/KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
CORN OIL
Page 609
1,2-Dihydro-2,2,4-trimethylquinoline (monomer)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05069-03
C60902
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/05/1986
SO
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 5 MG/KG
06 - 5 MG/KG
07 - 20 MG/KG
08 - 20 MG/KG
09 - 50 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 100 MG/KG
13 - 200 MG/KG
14 - 200 MG/KG
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 610
ACETONE
1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05069-04
C60902
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/28/1986
SO
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - VEHICLE CONTROL
04 - VEHICLE CONTROL
05 - 2.5 MG/KG
06 - 2.5 MG/KG
07 - 5 MG/KG
08 - 5 MG/KG
09 - 10 MG/KG
10 - 10 MG/KG
11 - 20 MG/KG
12 - 20 MG/KG
13 - 50 MG/KG
14 - 50 MG/KG
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 611
ACETONE
1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
DERM SOL
05069-06
C60902B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SENCAR
11/20/1989
MA
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - DMBA/TMQ5 MG/KG
02 - DMBA/TMQ10 MG/KG
03 - DMBA/TMQ25 MG/KG
04 - ACET/TMQ5 MG/KG
05 - ACET/TMQ10 MG/KG
06 - ACET/TMQ25 MG/KG
07 - TMQ/TPA
08 - DMBA/TPA
09 - DMBA/ ACETONE
10 - ACETONE/TPA
11 - ACETONE/ACETONE
T
T
T
T
T
T
T
P
I
R
V
F
F
F
F
F
F
F
F
F
F
F
ACETONE
Page 612
1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05069-07
C60902D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/06/1989
MA
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3.6 MG/KG
04 - 3.6 MG/KG
05 - 6.0 MG/KG
06 - 6.0 MG/KG
07 - 10.0 MG/KG
08 - 10.0 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 613
1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05069-08
C60902D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/12/1989
MA
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 36 MG/KG
04 - 36 MG/KG
05 - 60 MG/KG
06 - 60 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 614
1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05069-09
C60902B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/22/1989
MA
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6.0 MG/K
04 - 6.0 MG/K
05 - 10.0 MG/KG
06 - 10.0 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
ACETONE
Page 615
1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05069-10
C60902B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/31/1989
MA
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 60 MG/KG
04 - 60 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
ACETONE
Page 616
1,2-Dihydro-2,2,4-trimethylquinoline (monomer) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
DERM SOL
05069-11
C60902C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/10/1989
MA
147-47-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - DEN/TMQ
02 - DEN/ ACETONE
03 - DEN/PB
04 - TMQ/ ACETONE
05 - TMQ/PB
06 - SALINE/ ACETONE
07 - SALINE/ PB
T
I
P
T
T
N
P
M
M
M
M
M
M
M
ACETONE, SALINE
Page 617
DEIONIZED WATER, SALINE
ACETONE
ACETONE, DEIONIZED WATER
ACETONE, SALINE
DEIONIZED WATER, SALINE
Diisopropylcarbodiimide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
93020-01
C93020
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/06/1994
MB
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 10 MG/ML
03 - 30 MG/ML
04 - 90 MG/ML
05 - 269 MG/ML
06 - 806 MG/ML
07 - VEHICLE CONTROL
08 - 10 MG/ML
09 - 30 MG/ML
10 - 90 MG/ML
11 - 269 MG/ML
12 - 806 MG/ML
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 618
Diisopropylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
93020-02
C93020
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/08/1994
MB
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 10 MG/ML
03 - 30 MG/ML
04 - 90 MG/ML
05 - 269 MG/ML
06 - 806 MG/ML
07 - VEHICLE CONTROL
08 - 10 MG/ML
09 - 30 MG/ML
10 - 90 MG/ML
11 - 269 MG/ML
12 - 806 MG/ML
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ACETONE
Page 619
Diisopropylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
93020-03
C93020
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/06/1994
MB
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 10 MG/KG
03 - 20 MG/KG
04 - 40 MG/KG
05 - 80 MG/KG
06 - 160 MG/KG
07 - 0 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 40 MG/KG
11 - 80 MG/KG
12 - 160 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 620
Diisopropylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
93020-04
C93020
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/08/1994
MB
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 17.5 MG/KG
03 - 35 MG/KG
04 - 70 MG/KG
05 - 140 MG/KG
06 - 280 MG/KG
07 - 0 MG/KG
08 - 17.5 MG/KG
09 - 35 MG/KG
10 - 70 MG/KG
11 - 140 MG/KG
12 - 280 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 621
Diisopropylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
SKIN
93020-05
C93020B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
06/14/1995
MB
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 4.38 MG/KG
03 - 8.75 MG/KG
04 - 17.5 MG/KG
05 - 35 MG/KG
06 - 70 MG/KG
V
T
T
T
T
T
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 622
Diisopropylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
93020-06
C93020C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
01/04/1999
MB
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 4.38 MG/KG
03 - 8.75 MG/KG
04 - 17.5 MG/KG
05 - 35 MG/KG
06 - 70 MG/KG
V
T
T
T
T
T
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 623
Diisopropylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
93020-07
C93020D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/24/2000
SO
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 624
Diisopropylcarbodiimide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
93020-08
C93020D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/08/2000
SO
693-13-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 625
Dimethoxane
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05038-01
C56213
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/30/1982
BC
828-00-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 62.5 MG/KG
04 - 125 MG/ KG
05 - 125 MG/ KG
06 - 250 MG/ KG
V
V
T
T
T
T
M
F
M
M
F
F
CORN OIL
Page 626
Dimethoxane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05038-02
C56213
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/23/1982
BC
828-00-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 250 MG/ KG
04 - 250 MG/ KG
05 - 500 MG/ KG
06 - 500 MG/ KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 627
3,3'-Dimethoxybenzidine dihydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05172-01
C99989
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/29/1983
HZ
20325-40-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 80 PPM
04 - 80 PPM
05 - 170 PPM
06 - 170 PPM
07 - 330 PPM
08 - 330 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 628
Dimethylaminopropyl chloride, hydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96006-01
C96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/31/1999
MB
5407-04-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 629
Dimethylaminopropyl chloride, hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96006-02
C96006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/01/1999
MB
5407-04-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 630
Dimethylaminopropyl chloride, hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
96006-03
C96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/31/2000
MB
5407-04-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 100 MG/KG
03 - 200 MG/KG
04 - 400 MG/KG
05 - 800 MG/KG
06 - 1000 MG/KG
07 - VEHICLE CONTROL
08 - 100 MG/KG
09 - 200 MG/KG
10 - 400 MG/KG
11 - 800 MG/KG
12 - 1000 MG/KG
13 - CONTROL SPECIAL
14 - 100MG/KGSPECIAL
15 - 200MG/KGSPECIAL
16 - 400MG/KGSPECIAL
17 - 800MG/KGSPECIAL
18 - 1000MG/KSPECIAL
19 - VEHICLE CONTROL
20 - 100 MG/KG
21 - 200 MG/KG
22 - 400 MG/KG
23 - 800 MG/KG
24 - 1000 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 631
Dimethylaminopropyl chloride, hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
96006-04
C96006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/03/2000
MB
5407-04-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 50 MG/KG
03 - 100 MG/KG
04 - 200 MG/KG
05 - 400 MG/KG
06 - 800 MG/KG
07 - VEHICLE CONTROL
08 - 50 MG/KG
09 - 100 MG/KG
10 - 200 MG/KG
11 - 400 MG/KG
12 - 800 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 632
Dimethylaminopropyl chloride, hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
96006-05
C96006B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/12/2000
MB
5407-04-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
13 - CONTROL SPECIAL
14 - 6.25MG/KSPECIAL
15 - 12.5MG/KSPECIAL
16 - 25 MG/KGSPECIAL
17 - 50 MG/KGSPECIAL
18 - 100MG/KGSPECIAL
19 - VEHICLE SPECIAL
20 - 6.25MG/KSPECIAL
21 - 12.5MG/KSPECIAL
22 - 25 MG/KGSPECIAL
23 - 50 MG/KGSPECIAL
24 - 100MG/KGSPECIAL
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 633
Dimethylaminopropyl chloride, hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
96006-06
C96006B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/15/2000
MB
5407-04-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 6.25 MG/KG
03 - 12.5 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 6.25 MG/KG
09 - 12.5 MG/KG
10 - 25 MG/KG
11 - 50 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 634
3,3'-Dimethylbenzidine dihydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05166-01
C99990
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/30/1983
HZ
612-82-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.003
04 - 0.003
05 - 0.007
06 - 0.007
07 - 0.015
08 - 0.015
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DISTILLED WATER
Page 635
Dimethylformamide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05219-01
C60913B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/31/1989
BC
68-12-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM BASE
02 - 0 PPM BASE
03 - 50 PPM BASE
04 - 50 PPM BASE
05 - 100 PPM BASE
06 - 100 PPM BASE
07 - 200 PPM BASE
08 - 200 PPM BASE
09 - 400 PPM BASE
10 - 400 PPM BASE
11 - 800 PPM BASE
12 - 800 PPM BASE
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 636
Dimethylformamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05219-02
C60913B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/02/1989
BC
68-12-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 50 PPM
04 - 50 PPM
05 - 100 PPM
06 - 100 PPM
07 - 200 PPM
08 - 200 PPM
09 - 400 PPM
10 - 400 PPM
11 - 800 PPM
12 - 800 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 637
Dimethylformamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05219-03
C60913B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/31/1989
BC
68-12-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM CARDIO
02 - 0 PPM CARDIO
03 - 50 PPM CARDIO
04 - 50 PPM CARDIO
05 - 100 PPM CARDIO
06 - 100 PPM CARDIO
07 - 200 PPM CARDIO
08 - 200 PPM CARDIO
09 - 400 PPM CARDIO
10 - 400 PPM CARDIO
11 - 800 PPM CARDIO
12 - 800 PPM CARDIO
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 638
Dimethylformamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05219-04
C60913B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/31/1989
BC
68-12-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM REN MET
02 - 0 PPM REN MET
03 - 50 PPM REN MET
04 - 50 PPM REN MET
05 - 100 PPM REN MET
06 - 100 PPM REN MET
07 - 200 PPM REN MET
08 - 200 PPM REN MET
09 - 400 PPM REN MET
10 - 400 PPM REN MET
11 - 800 PPM REN MET
12 - 800 PPM REN MET
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 639
Dimethylformamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05219-05
C60913B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/31/1989
BC
68-12-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM REN FUN
02 - 0 PPM REN FUN
03 - 50 PPM REN FUN
04 - 50 PPM REN FUN
05 - 100 PPM REN FUN
06 - 100 PPM REN FUN
07 - 200 PPM REN FUN
08 - 200 PPM REN FUN
09 - 400 PPM REN FUN
10 - 400 PPM REN FUN
11 - 800 PPM REN FUN
12 - 800 PPM REN FUN
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 640
N,N-Dimethyl-p-toluidine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20107-01
C20107
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/20/2003
BC
99-97-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 62.5 MG/KG
04 - 62.5 MG/KG
05 - 125 MG/KG
06 - 125 MG/KG
07 - 250 MG/KG
08 - 250 MG/KG
09 - 500 MG/KG
10 - 500 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 641
N,N-Dimethyl-p-toluidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20107-02
C20107
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/22/2003
BC
99-97-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 15 MG/KG
04 - 15 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
07 - 60 MG/KG
08 - 60 MG/KG
09 - 125 MG/KG
10 - 125 MG/KG
11 - 250 MG/KG
12 - 250 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 642
N,N-Dimethyl-p-toluidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20107-03
C20107
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/20/2004
BC
99-97-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6 MG/KG
04 - 6 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 60 MG/KG
08 - 60 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 643
N,N-Dimethyl-p-toluidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20107-04
C20107
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/25/2004
BC
99-97-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6 MG/KG
04 - 6 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 60 MG/KG
08 - 60 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 644
N,N-Dimethyl-p-toluidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20107-98
C20107
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/20/2004
BC
99-97-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6 MG/KG
04 - 6 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 60 MG/KG
08 - 60 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 645
N,N-Dimethyl-p-toluidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20107-99
C20107
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/20/2003
BC
99-97-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 62.5 MG/KG
04 - 62.5 MG/KG
05 - 125 MG/KG
06 - 125 MG/KG
07 - 250 MG/KG
08 - 250 MG/KG
09 - 500 MG/KG
10 - 500 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 646
1,3-Diphenylguanidine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88003-03
C88003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/01/1990
MB
102-06-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 250 PPM
03 - 500 PPM
04 - 750 PPM
05 - 1500 PPM
06 - 3000 PPM
08 - CONTROL
09 - 250 PPM
10 - 500 PPM
11 - 750 PPM
12 - 1500 PPM
13 - 3000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 647
1,3-Diphenylguanidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88003-04
C88003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/26/1990
MB
102-06-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 250 PPM
03 - 500 PPM
04 - 750 PPM
05 - 1500 PPM
06 - 3000 PPM
07 - CONTROL
08 - 250 PPM
09 - 500 PPM
10 - 750 PPM
11 - 1500 PPM
12 - 3000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 648
1,3-Diphenylguanidine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88003-05
C88003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/01/1990
MB
102-06-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 250 PPM
03 - 500 PPM
04 - 750 PPM
05 - 1500 PPM
06 - 3000 PPM
07 - CONTROL
08 - 250 PPM
09 - 500 PPM
10 - 750 PPM
11 - 1500 PPM
12 - 3000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 649
5,5-Diphenylhydantoin (phenytoin)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05075-01
C55765
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/01/1982
BC
57-41-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM 0-0
02 - 0 PPM 10-0
03 - 240 PPM 1-1
04 - 800 PPM 0-3
05 - 800 PPM 3-3
06 - 800 PPM 10-3
07 - 2400 PPM 0-10
08 - 2400 PPM10-10
09 - 0 PPM 0-0
10 - 0 PPM 10-0
11 - 240 PPM 1-1
12 - 800 PPM 0-3
13 - 800 PPM 3-3
14 - 800 PPM 10-3
15 - 2400 PPM 0-10
16 - 2400 PPM 10-10
U
U
T
T
T
T
T
T
U
U
T
T
T
T
T
T
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
PURINA 5002 CERTIFIED CHOW
Page 650
5,5-Diphenylhydantoin (phenytoin) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05075-02
C55765
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/28/1982
BC
57-41-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM 0-0
02 - 0 PPM 10-0
03 - 30 PPM 1-1
04 - 100 PPM 10-3
05 - 100 PPM 3-3
06 - 100 PPM 0-3
07 - 300 PPM 10-10
08 - 300 PPM 0-10
09 - 0 PPM 0-0
10 - 0 PPM 10-0
11 - 60 PPM 1-1
12 - 200 PPM 10-3
13 - 200 PPM 3-3
14 - 200 PPM 0-3
15 - 600 PPM 10-10
16 - 600 PPM 0-10
U
U
T
T
T
T
T
T
U
U
T
T
T
T
T
T
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
PURINA 5002 CERTIFIED CHOW
Page 651
Dipropylene glycol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88031-03
C88031
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/09/1990
AD
25265-71-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.5%
03 - 1.0%
04 - 2.0%
05 - 4.0%
06 - 8.0%
07 - VEHICLE CONTROL
08 - 0.5%
09 - 1.0%
10 - 2.0%
11 - 4.0%
12 - 8.0%
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 652
Dipropylene glycol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88031-04
C88031
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/11/1990
AD
25265-71-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.5%
03 - 1.0%
04 - 2.0%
05 - 4.0%
06 - 8.0%
07 - VEHICLE CONTROL
08 - 0.5%
09 - 1.0%
10 - 2.0%
11 - 4.0%
12 - 8.0%
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 653
Dipropylene glycol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
88031-05
C88031B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/31/1997
BC
25265-71-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.25%
04 - 0.25%
05 - 1.0%
06 - 1.0%
07 - 4.0%
08 - 4.0%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 654
Dipropylene glycol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
88031-06
C88031B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/18/1997
BC
25265-71-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 1.0%
04 - 1.0%
05 - 2.0%
06 - 2.0%
07 - 4.0%
08 - 4.0%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 655
Diquat dibromide monohydrate
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
INTP INJ
20513-01
C20513
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/26/2005
IL
6385-62-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 10 MG/KG
02 - 25 MG/KG
03 - 30 MG/KG
04 - 0 MG/KG
T
T
T
V
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 656
Diquat dibromide monohydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
INTP INJ
20513-02
C20513B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/01/2005
IL
6385-62-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0MG/KG6 HRS
02 - 5.0MG/KG6 HRS
03 - 10MG/KG 6 HRS
04 - 20MG/KG 6 HRS
05 - 25MG/KG 6 HRS
06 - 0.0MG/KG24 HRS
07 - 5.0MG/KG24 HRS
08 - 10MG/KG 24 HRS
09 - 20MG/KG 24 HRS
10 - 25MG/KG 24 HRS
11 - 0.0MG/KG48 HRS
12 - 5.0MG/KG48 HRS
13 - 10MG/KG 48 HRS
14 - 20MG/KG 48 HRS
15 - 25MG/KG 48 HRS
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 657
Divinylbenzene
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
88004-01
C88004B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/23/1998
BN
1321-74-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 658
Divinylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
88004-02
C88004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/23/1998
BN
1321-74-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 659
Divinylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88004-03
C88004B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/22/1998
BN
1321-74-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 660
Divinylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88004-04
C88004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/22/1998
BN
1321-74-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 12.5 PPM
04 - 12.5 PPM
05 - 25 PPM
06 - 25 PPM
07 - 50 PPM
08 - 50 PPM
09 - 100 PPM
10 - 100 PPM
11 - 200 PPM
12 - 200 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 661
Divinylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88004-05
C88004B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/13/1999
BN
1321-74-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 662
Divinylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88004-06
C88004B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/27/1999
BN
1321-74-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 10 PPM
04 - 10 PPM
05 - 30 PPM
06 - 30 PPM
07 - 100 PPM
08 - 100 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 663
Elmiron (sodium pentosanpolysulfate)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88122-01
C88122B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/03/1995
MB
37319-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 33 MG/KG
03 - 111 MG/KG
04 - 333 MG/KG
05 - 1000 MG/KG
06 - 3000 MG/KG
07 - 0 MG/KG
08 - 33 MG/KG
09 - 111 MG/KG
10 - 333 MG/KG
11 - 1000 MG/KG
12 - 3000 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 664
Elmiron (sodium pentosanpolysulfate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88122-02
C88122B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/04/1995
MB
37319-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 33 MG/KG
03 - 111 MG/KG
04 - 333 MG/KG
05 - 1000 MG/KG
06 - 3000 MG/KG
07 - 0 MG/KG
08 - 33 MG/KG
09 - 111 MG/KG
10 - 333 MG/KG
11 - 1000 MG/KG
12 - 3000 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 665
Elmiron (sodium pentosanpolysulfate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88122-03
C88122
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/25/1996
BC
37319-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 63 MG/KG
04 - 63 MG/KG
05 - 125 MG/KG
06 - 125 MG/KG
07 - 250 MG/KG
08 - 250 MG/KG
09 - 500 MG/KG
10 - 500 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 666
Elmiron (sodium pentosanpolysulfate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88122-04
C88122
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/27/1996
BC
37319-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 63 MG/KG
04 - 63 MG/KG
05 - 125 MG/KG
06 - 125 MG/KG
07 - 250 MG/KG
08 - 250 MG/KG
09 - 500 MG/KG
10 - 500 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 667
Elmiron (sodium pentosanpolysulfate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88122-05
C88122
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/25/1996
BC
37319-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 63 MG/KG
04 - 63 MG/KG
05 - 125 MG/KG
06 - 125 MG/KG
07 - 250 MG/KG
08 - 250 MG/KG
09 - 500 MG/KG
10 - 500 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 668
Elmiron (sodium pentosanpolysulfate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88122-06
C88122
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/25/1997
BC
37319-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 14 MG/KG
04 - 28 MG/KG
05 - 42 MG/KG
06 - 84 MG/KG
07 - 126 MG/KG
08 - 252 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 669
Elmiron (sodium pentosanpolysulfate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88122-07
C88122
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/30/1997
BC
37319-17-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 56 MG/KG
04 - 56 MG/KG
05 - 168 MG/KG
06 - 168 MG/KG
07 - 504 MG/KG
08 - 504 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 670
Emodin
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05211-03
C62408
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/30/1989
SO
518-82-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 0.03125%
04 - 0.03125%
05 - 0.0625%
06 - 0.0625%
07 - 0.125%
08 - 0.125%
09 - 0.25%
10 - 0.25%
11 - 0.50%
12 - 0.50%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 671
Emodin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05211-04
C62408
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/06/1989
SO
518-82-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - UNTREATDCONTROL
03 - 0.03125%
04 - 0.03125%
05 - 0.0625%
06 - 0.0625%
07 - 0.125%
08 - 0.125%
09 - 0.25%
10 - 0.25%
11 - 0.50%
12 - 0.50%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 672
Emodin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05211-05
C62408
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/30/1994
SO
518-82-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 280 PPM
04 - 280 PPM
05 - 830 PPM
06 - 830 PPM
07 - 2500 PPM
08 - 2500 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 673
Emodin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05211-06
C62408
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/08/1994
SO
518-82-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 160 PPM
04 - 312 PPM
05 - 312 PPM
06 - 625 PPM
07 - 625 PPM
08 - 1250 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 674
Emodin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05211-07
C62408
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/30/1994
SO
518-82-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 280 PPM
04 - 280 PPM
05 - 830 PPM
06 - 830 PPM
07 - 2500 PPM
08 - 2500 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 675
ENDOCRINE DISRUPTOR(Nonylphenol)
TEST:
ROUTE:
TDMS #:
NTP #:
MULTIGEN CHRONIC
FEED
99910-94
MG96003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
01/01/2000
NR
84852-15-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F0 Control
02 - F0 25PPM
03 - F0 200 PPM
04 - F0 750 PPM
05 - F0 Control
06 - F0 25PPM
07 - F0 200PPM
08 - F0 750 PPM
09 - F1 Control
10 - F1 25 PPM
11 - F1 200 PPM
12 - F1 750 PPM
13 - F1 Control
14 - F1 25 PPM
15 - F1 200 PPM
16 - F1 750 PPM
17 - F2 Control
18 - F2 25 PPM
19 - F2 200 PPM
20 - F2 750 PPM
21 - F2 Control
22 - F2 25 PPM
23 - F2 200 PPM
24 - F2 750 PPM
25 - F3 Control
26 - F3/25PPM TO CTL
27 - F3/200PPM TO CTL
28 - F3/750PPM TO CTL
29 - F3 Control
30 - F3/25PPM TO CTL
31 - F3/200PPM TO CTL
32 - F3/750PPM TO CTL
33 - F4 Control
34 - F4/25PPM TO CTL
35 - F4/200PPM TO CTL
36 - F4/750PPM TO CTL
37 - F4 Control
38 - F4/25PPM TO CTL
39 - F4/200PPM TO CTL
40 - F4/750PPM TO CTL
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 676
ENDOCRINE DISRUPTOR(Nonylphenol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99910-95
MG96003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
04/10/2000
NR
84852-15-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F4 CONTROL
02 - F4/25PPM TO CTL
03 - F4/200PPM TO CTL
04 - F4/750PPM TO CTL
05 - F4 CONTROL
06 - F4/25PPM TO CTL
07 - F4/200PPM TO CTL
08 - F4/750PPM TO CTL
V
V
V
V
V
V
V
V
F
F
F
F
M
M
M
M
5k96 Meal
Page 677
ENDOCRINE DISRUPTOR(Nonylphenol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99910-96
MG96003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
01/01/2000
NR
84852-15-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F3 CONTROL
02 - F3/25PPM TO CTL
03 - F3/200PPM TO CTL
04 - F3/750PPM TO CTL
05 - F3 CONTROL
06 - F3/25PPM TO CTL
07 - F3/200PPM TO CTL
08 - F3/750PPM TO CTL
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
5k96 Meal
Page 678
ENDOCRINE DISRUPTOR(Nonylphenol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99910-97
MG96003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
09/13/1999
NR
84852-15-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F2 CONTROL
02 - F2 25 PPM
03 - F2 200 PPM
04 - F2 750 PPM
05 - F2 CONTROL
06 - F2 25 PPM
07 - F2 200 PPM
08 - F2 750 PPM
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
5k96 Meal
Page 679
ENDOCRINE DISRUPTOR(Nonylphenol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99910-98
MG96003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
05/31/1999
NR
84852-15-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1 CONTROL
02 - F1 25 PPM
03 - F1 200 PPM
04 - F1 750 PPM
05 - F1 CONTROL
06 - F1 25 PPM
07 - F1 200 PPM
08 - F1 750 PPM
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
5k96 Meal
Page 680
ENDOCRINE DISRUPTOR(Nonylphenol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99910-99
MG96003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
03/16/1999
NR
84852-15-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F0 CONTROL
02 - F0 25PPM
03 - F0 200 PPM
04 - F0 750 PPM
05 - F0 CONTROL
06 - F0 25PPM
07 - F0 200PPM
08 - F0 750 PPM
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
5k96 Meal
Page 681
Ephedrine + caffeine combination
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
04024-01
C04024
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/18/2009
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0/mg/kg
02 - 12.5/30 mg/kg
03 - 25/30 mg/kg
04 - 50/15 mg/kg
05 - 50/30/mg/kg
06 - 75/30 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 682
Ephedrine + caffeine combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
04024-02
C04024B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3H/HeJ
04/14/2010
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 50/30 mg/kg
03 - 100/30 mg/kg
04 - 200/30 mg/kg
V
T
T
T
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 683
Ephedrine + caffeine combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
04024-03
C04024B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1J
06/30/2010
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 50/30 mg/kg
03 - 100/30 mg/kg
04 - 200/30 mg/kg
V
T
T
T
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 684
Ephedrine + caffeine combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
04024-04
C04024B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
05/19/2010
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 50/30 mg/kg
03 - 100/30 mg/kg
04 - 200/30 mg/kg
V
T
T
T
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 685
Ephedrine + caffeine combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
04024-05
C04024B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3H/HeJ
06/01/2010
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 12.5/30 mg/kg
03 - 25/30 mg/kg
04 - 50/30 mg/kg
05 - 100/30 mg/kg
06 - 200/30 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 686
Ephedrine + caffeine combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
04024-06
C04024B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1J
06/01/2010
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 12.5/30 mg/kg
03 - 25/30 mg/kg
04 - 50/30 mg/kg
05 - 100/30 mg/kg
06 - 200/30 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 687
Ephedrine + caffeine combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
04024-07
C04024B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
06/01/2010
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 12.5/30 mg/kg
03 - 25/30 mg/kg
04 - 50/30 mg/kg
05 - 100/30 mg/kg
06 - 200/30 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 688
Ephedrine + caffeine combination (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20401-01
C20401
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/29/2004
BC
EPHEDCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - EPH 6.25MG/KG
03 - EPH 12.5MG/KG
04 - EPH 25 MG/KG
05 - E12.5/C 7.25MGKG
06 - E25C7.25MG/KG
07 - CAF 15 MG/KG
08 - E12.5/ C15MG/KG
09 - E25/C15 MG/KG
10 - CAF 30 MG/KG
11 - E6.25/ C30MG/KG
12 - E12.5/ C30MG/KG
13 - E25/C30 MG/KG
V
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 689
Epinephrine hydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05095-01
C55663
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/03/1982
BN
55-31-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 1.5MG/M3 MALE
04 - 1.5MG/M3 FEMALE
05 - 5.0MG/M3 MALE
06 - 5.0MG/M3 FEMALE
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 690
Epinephrine hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05095-02
C55663
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/29/1982
BN
55-31-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - CONTROL FEMALE
03 - 1.5MG/M3 MALE
04 - 1.5MG/M3 FEMALE
05 - 3.0MG/M3 MALE
06 - 3.0MG/M3 FEMALE
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 691
Estragole
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
60946-01
C60946
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/10/2001
BC
140-67-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 692
Estragole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
60946-02
C60946
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/12/2001
BC
140-67-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 693
Estragole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
60946-99
C60946
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/10/2001
BC
140-67-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 694
Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
20307-03
C20307
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
12/12/2006
MB
54464-57-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - untreated
02 - vehicle
03 - 6.25%
04 - 12.5%
05 - 25%
06 - 50%
07 - 100%
08 - untreated
09 - vehicle
10 - 6.25%
11 - 12.5%
12 - 25%
13 - 50%
14 - 100%
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NTP 2000 (IRRADIATED)
ETHANOL (95%) : WATER (100:0)
Page 695
NTP 2000 (IRRADIATED)
ETHANOL (95%) : WATER (100:0)
Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
20307-04
C20307
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/14/2006
MB
54464-57-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - untreated
02 - vehicle
03 - 6.25%
04 - 12.5 %
05 - 25 %
06 - 50 %
07 - 100 %
09 - untreated
10 - vehicle
11 - 6.25 %
12 - 12.5 %
13 - 25 %
14 - 50 %
15 - 100 %
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NTP 2000 (IRRADIATED)
ETHANOL (95%) : WATER (100:0)
Page 696
NTP 2000 (IRRADIATED)
ETHANOL (95%) : WATER (100:0)
Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
20307-99
C20307
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
12/12/2006
MB
54464-57-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - untreated
02 - vehicle
03 - 6.25%
04 - 12.5%
05 - 25%
06 - 50%
07 - 100%
08 - untreated
09 - vehicle
10 - 6.25%
11 - 12.5%
12 - 25%
13 - 50%
14 - 100%
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NTP 2000 (IRRADIATED)
ETHANOL (95%) : WATER (100:0)
Page 697
NTP 2000 (IRRADIATED)
ETHANOL (95%) : WATER (100:0)
Ethinyl estradiol
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SUBCUT
20326-01
C20326
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/17/2004
IL
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 1 DAY
02 - 1 MG/KG 1 DAY
03 - 5 MG/KG 1 DAY
04 - 0 MG/KG 2 DAY
05 - 1 MG/KG 2 DAY
06 - 5 MG/KG 2 DAY
07 - 0 MG/KG 4 DAY
08 - 1 MG/KG 4 DAY
09 - 5 MG/KG 4 DAY
10 - 0 MG/KG 6 DAY
11 - 1 MG/KG 6 DAY
12 - 5 MG/KG 6 DAY
13 - 0 MG/KG 15 DAY
14 - 1 MG/KG 15 DAY
15 - 5 MG/KG 15 DAY
V
T
T
V
T
T
V
T
T
V
T
T
V
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
PROPYLENE GLYCOL
Page 698
Ethylbenzene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05210-01
C56393
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/29/1988
TR
100-41-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 100 PPM
03 - 250 PPM
04 - 500 PPM
05 - 750 PPM
06 - 1000 PPM
07 - CONTROL
08 - 100 PPM
09 - 250 PPM
10 - 500 PPM
11 - 750 PPM
12 - 1000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 699
Ethylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05210-02
C56393
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/01/1988
TR
100-41-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 100 PPM
03 - 250 PPM
04 - 500 PPM
05 - 750 PPM
06 - 1000 PPM
07 - CONTROL
08 - 100 PPM
09 - 250 PPM
10 - 500 PPM
11 - 750 PPM
12 - 1000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 700
Ethylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05210-03
C56393B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/07/1990
TR
100-41-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 75 PPM
03 - 250 PPM
04 - 750 PPM
05 - CONTROL
06 - 75 PPM
07 - 250 PPM
08 - 750 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
AIR
Page 701
Ethylbenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05210-04
C56393B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/05/1990
TR
100-41-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 75 PPM
03 - 250 PPM
04 - 750 PPM
05 - CONTROL
06 - 75 PPM
07 - 250 PPM
08 - 750 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
AIR
Page 702
Ethylene glycol
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05025-01
C00920A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/28/1982
SO
107-21-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 2.5%
04 - 5.0%
05 - 1.25%
06 - 2.5%
07 - 0.625%
08 - 1.25%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 703
Ethylene glycol monoethyl ether (EGMEE)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05198-03
C54853B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/03/1988
MA
110-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1250 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
09 - 10000 PPM
10 - 10000 PPM
11 - 20000 PPM
12 - 20000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 704
Ethylene glycol monoethyl ether (EGMEE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05198-05
C54853B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/06/1988
MA
110-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5000 PPM
03 - 10000 PPM
04 - 20000 PPM
U
T
T
T
M
M
M
M
DEIONIZED WATER
Page 705
Ethylene glycol monoethyl ether (EGMEE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
8-WEEK
WATER
05198-06
C54853D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/03/1988
MA
110-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM LEUKEMIA
03 - 2500 PPM
04 - 2500 PPMLEUKEMIA
05 - 5000 PPM
06 - 5000 PPMLEUKEMIA
U
P
T
T
T
T
M
M
M
M
M
M
DEIONIZED WATER
Page 706
Ethylene glycol monoethyl ether (EGMEE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05198-07
C54853B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/26/1988
MA
110-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
07 - 10000 PPM
08 - 10000 PPM
09 - 20000 PPM
10 - 20000 PPM
11 - 40000 PPM
12 - 40000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 707
Ethylene Glycol Monomethyl Ether (EGMME)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05199-03
C62135
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/19/1988
MA
109-86-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 750 PPM
04 - 750 PPM
05 - 1500 PPM
06 - 1500 PPM
07 - 3000 PPM
08 - 3000 PPM
09 - 4500 PPM
10 - 4500 PPM
11 - 6000 PPM
12 - 6000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 708
Ethylene Glycol Monomethyl Ether (EGMME) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05199-05
C62135
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/22/1988
MA
109-86-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1500 PPM
03 - 3000 PPM
04 - 6000 PPM
U
T
T
T
M
M
M
M
DEIONIZED WATER
Page 709
Ethylene Glycol Monomethyl Ether (EGMME) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
8-WEEK
WATER
05199-06
C62135C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/19/1988
MA
109-86-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM LEUKEMIA
03 - 3000 PPM
04 - 3000 PPMLEUKEMIA
05 - 6000 PPM
06 - 6000 PPMLEUKEMIA
U
P
T
T
T
T
M
M
M
M
M
M
DEIONIZED WATER
Page 710
Ethylene Glycol Monomethyl Ether (EGMME) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05199-07
C62135
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/12/1988
MA
109-86-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2000 PPM
04 - 2000 PPM
05 - 4000 PPM
06 - 4000 PPM
07 - 6000 PPM
08 - 6000 PPM
09 - 8000 PPM
10 - 8000 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 711
Ethylene thiourea (ETU)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05076-01
C03372
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/24/1983
BC
96-45-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM 0-0
02 - 0 PPM 10-0
03 - 25 PPM 1-1
04 - 83 PPM 0-3
05 - 83 PPM 3-3
06 - 83 PPM 10-3
07 - 250 PPM 0-10
08 - 250 PPM 10-10
09 - 0 PPM 0-0
10 - 0 PPM 10-0
11 - 25 PPM 1-1
12 - 83 PPM 0-3
13 - 83 PPM 3-3
14 - 83 PPM 10-3
15 - 250 PPM 0-10
16 - 250 PPM 10-10
U
T
T
T
T
T
T
T
U
U
T
T
T
T
T
T
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
PURINA 5002 CERTIFIED CHOW
Page 712
Ethylene thiourea (ETU) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05076-02
C03372
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/15/1982
BC
96-45-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM 0-0
02 - 0 PPM 10-0
03 - 100 PPM 1-1
04 - 333 PPM 0-3
05 - 333 PPM 3-3
06 - 333 PPM 10-3
07 - 1000 PPM 0-10
08 - 1000 PPM 10-10
09 - 0 PPM 0-0
10 - 0 PPM 10-0
11 - 100 PPM 1-1
12 - 333 PPM 0-3
13 - 333 PPM 3-3
14 - 333 PPM 10-3
15 - 1000 PPM 0-10
16 - 1000 PPM 10-10
U
U
T
T
T
T
T
T
U
U
T
T
T
T
T
T
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
PURINA 5002 CERTIFIED CHOW
Page 713
Eugenol
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
50453-01
C50453B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/17/2003
NE
97-53-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL 1D/6HR
02 - 276MGKG 1D/6HR
03 - 920MGKG 1D/6HR
04 - CONTROL 1D/24HR
05 - 276MGKG 1D/24HR
06 - 920MGKG 1D/24HR
07 - CONTROL 1D/72HR
08 - 276MGKG 1D/72HR
09 - 920MGKG 1D/72HR
10 - CONTROL 3D/24HR
11 - 276MGKG 3D/24HR
12 - 920MGKG 3D/24HR
13 - CONTROL 7D/24HR
14 - 276MGKG 7D/24HR
15 - 920MGKG 7D/24HR
16 - CONTROL 14D/24HR
17 - 276MGKG 14D/24HR
18 - 920MGKG 14D/24HR
19 - CONTROL 14D/3MO
20 - 276MGKG 14D/3MO
21 - 920MGKG 14D/3MO
22 - CONTROL 14D/6MO
23 - 276MGKG 14D/6MO
24 - 920MGKG 14D/6MO
V
T
T
V
T
T
V
T
T
V
T
T
V
T
T
V
T
T
V
T
T
V
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 714
Ferrocene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05218-03
C62066
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/11/1989
LI
102-54-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0MG/M3BASIC M
02 - 0.0MG/M3SPECIALM
03 - 0.0MG/M3BASIC F
04 - 0.0MG/M3SPECIALF
05 - 3.0MG/M3BASIC M
06 - 3.0MG/M3SPECIALM
07 - 3.0MG/M3BASIC F
08 - 3.0MG/M3SPECIALF
09 - 10.MG/M3BASIC M
10 - 10.MG/M3SPECIALM
11 - 10.MG/M3BASIC F
12 - 10.MG/M3SPECIALF
13 - 30.MG/M3BASIC M
14 - 30.MG/M3SPECIALM
15 - 30.MG/M3BASIC F
16 - 30.MG/M3SPECIALF
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
AIR
Page 715
(UNSPECIFIED)
Ferrocene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05218-04
C62066
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/05/1989
LI
102-54-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0MG/M3MALE
02 - 0.0MG/M3FEMALE
03 - 3.0MG/M3MALE
04 - 3.0MG/M3FEMALE
05 - 10.MG/M3MALE
06 - 10.MG/M3FEMALE
07 - 30.MG/M3MALE
08 - 30.MG/M3FEMALE
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 716
(UNSPECIFIED)
Formamide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88123-01
C88123
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/09/1997
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 160 MG/KG
04 - 160 MG/KG
05 - 312 MG/KG
06 - 312 MG/KG
07 - 625 MG/KG
08 - 625 MG/KG
09 - 1250 MG/KG
10 - 1250 MG/KG
11 - 2500 MG/KG
12 - 2500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 717
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88123-02
C88123
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/10/1997
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 160 MG/KG
04 - 160 MG/KG
05 - 312 MG/KG
06 - 312 MG/KG
07 - 625 MG/KG
08 - 625 MG/KG
09 - 1250 MG/KG
10 - 1250 MG/KG
11 - 2500 MG/KG
12 - 2500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 718
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88123-03
C88123
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/13/1997
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 719
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88123-04
C88123
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/15/1997
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 720
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88123-05
C88123B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/20/2001
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 20 MG/KG
04 - 20 MG/KG
05 - 40 MG/KG
06 - 40 MG/KG
07 - 80 MG/KG
08 - 80 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 721
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88123-06
C88123B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(NOT DEFINED)
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 20 MG/KG
04 - 20 MG/KG
05 - 40 MG/KG
06 - 40 MG/KG
07 - 80 MG/KG
08 - 80 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 722
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88123-07
C88123B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/03/2001
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 20 MG/KG
04 - 20 MG/KG
05 - 40 MG/KG
06 - 40 MG/KG
07 - 80 MG/KG
08 - 80 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 723
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88123-97
C88123
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/15/1997
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 724
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88123-98
C88123
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/13/1997
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 725
Formamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
88123-99
C88123
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/13/1997
BC
75-12-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 40 MG/KG
08 - 40 MG/KG
09 - 80 MG/KG
10 - 80 MG/KG
11 - 160 MG/KG
12 - 160 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 726
Formic acid
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05183-05
C61905
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/14/1987
BN
64-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 8 PPM
04 - 8 PPM
05 - 16 PPM
06 - 16 PPM
07 - 32 PPM
08 - 32 PPM
09 - 64 PPM
10 - 64 PPM
11 - 128 PPM
12 - 128 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 727
Formic acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05183-06
C61905
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/16/1987
BN
64-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 8 PPM
04 - 8 PPM
05 - 16 PPM
06 - 16 PPM
07 - 32 PPM
08 - 32 PPM
09 - 64 PPM
10 - 64 PPM
11 - 128 PPM
12 - 128 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 728
Fumonisin B1
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92002-03
C92002B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
02/17/1995
NR
116355-83-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM/M FUMON-01
02 - 5PPM/M FUMON-02
03 - 15PPM/M FUMON-03
04 - 50PPM/M FUMON-04
05 - 150PPM/MFUMON-05
10 - 0PPM/F FUMON-10
11 - 5PPM/F FUMON-11
12 - 15PPM/F FUMON-12
13 - 50PPM/F FUMON-13
14 - 100PPM/FFUMON-14
U
T
T
T
T
U
T
T
T
T
M
M
M
M
M
F
F
F
F
F
(UNSPECIFIED)
Page 729
Fumonisin B1 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92002-04
C92002B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
03/01/1995
NR
116355-83-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5 PPM
03 - 15 PPM
04 - 80 PPM
05 - 150 PPM
07 - 0 PPM
08 - 5 PPM
09 - 15 PPM
10 - 50 PPM
11 - 80 PPM
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
F
F
F
F
F
(UNSPECIFIED)
Page 730
Furan
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05004-03
C56202
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/29/1982
SO
110-00-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 8 MG/KG
04 - 8 MG/KG
05 - 4 MG/KG
06 - 4 MG/KG
07 - 2 MG/KG
08 - 2 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 731
Furan (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05004-04
C56202
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/31/1982
SO
110-00-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 15 MG/KG
04 - 15 MG/KG
05 - 8 MG/KG
06 - 8 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 732
Furan (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
10119-01
C10119
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
01/11/2010
NR
110-00-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 Vehicle 104 wk
02 - 0.02 Furan 104wk
03 - 0.044 Furan104wk
04 - 0.092 Furan104wk
05 - 0.2 Furan 104 wk
06 - 0.44 Furan 104wk
07 - 0.92 Furan 104wk
08 - 2 Furan 104 wk
09 - 0 Vehicle 60 wk
10 - 0.02 Furan 60 wk
11 - 0.044 Furan 60wk
12 - 0.092 Furan 60wk
13 - 0.2 Furan 60 wk
14 - 0.44 Furan 60 wk
15 - 0.92 Furan 60 wk
16 - 2 Furan 60 wk
17 - 0 Vehicle 36 wk
18 - 0.02 Furan 36 wk
19 - 0.044 Furan 36wk
20 - 0.092 Furan 36wk
21 - 0.2 Furan 36 wk
22 - 0.44 Furan 36 wk
23 - 0.92 Furan 36 wk
24 - 2 Furan 36 wk
V
T
T
T
T
T
T
T
V
T
T
T
T
T
T
T
V
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
CORN OIL
Page 733
Furfural
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05005-07
C56177
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/16/1982
SO
98-01-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 60 MG/KG
04 - 60 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 734
Furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05005-08
C56177
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/09/1982
SO
98-01-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 175 MG/KG
04 - 175 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 735
Furfuryl alcohol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05201-03
C56224B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/19/1988
BN
98-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 2 PPM
04 - 2 PPM
05 - 4 PPM
06 - 4 PPM
07 - 8 PPM
08 - 8 PPM
09 - 16 PPM
10 - 16 PPM
11 - 32 PPM
12 - 32 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 736
Furfuryl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05201-04
C56224B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/20/1988
BN
98-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 2 PPM
04 - 2 PPM
05 - 4 PPM
06 - 4 PPM
07 - 8 PPM
08 - 8 PPM
09 - 16 PPM
10 - 16 PPM
11 - 32 PPM
12 - 32 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 737
Furfuryl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05201-05
C56224C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/26/1991
BN
98-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 2.0 PPM
04 - 2.0 PPM
05 - 8.0 PPM
06 - 8.0 PPM
07 - 32.0 PPM
08 - 32.0 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 738
Furfuryl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05201-06
C56224C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/21/1991
BN
98-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 2.0 PPM
04 - 2.0 PPM
05 - 8.0 PPM
06 - 8.0 PPM
07 - 32.0 PPM
08 - 32.0 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 739
Galactosamine HCl
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
INTP INJ
20502-01
C20502
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/07/2004
IL
1772-03-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6HR
02 - 25 MG/KG 6HR
03 - 100 MG/KG 6HR
04 - 400 MG/KG 6HR
05 - 0 MG/KG 24HR
06 - 25 MG/KG 24HR
07 - 100 MG/KG 24HR
08 - 400 MG/KG 24HR
09 - 0 MG/KG 48HR
10 - 25 MG/KG 48HR
11 - 100 MG/KG 48HR
12 - 400 MG/KG 48HR
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 740
Gallium arsenide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05180-04
C62033
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/06/1989
BN
1303-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.1 MG/M3
04 - 0.1 MG/M3
05 - 1 MG/M3
06 - 1 MG/M3
07 - 10 MG/M3
08 - 10 MG/M3
09 - 37 MG/M3
10 - 37 MG/M3
11 - 75 MG/M3
12 - 75 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 741
Gallium arsenide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05180-05
C62033
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/07/1989
BN
1303-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.1 MG/M3
04 - 0.1 MG/M3
05 - 1 MG/M3
06 - 1 MG/M3
07 - 10 MG/M3
08 - 10 MG/M3
09 - 37 MG/M3
10 - 37 MG/M3
11 - 75 MG/M3
12 - 75 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 742
Gallium arsenide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05180-06
C62033B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/30/1993
BN
1303-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.01 MG/M3
04 - 0.01 MG/M3
05 - 0.1 MG/M3
06 - 0.1 MG/M3
07 - 1.0 MG/M3
08 - 1.0 MG/M3
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 743
Gallium arsenide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05180-07
C62033B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/16/1993
BN
1303-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.1 MG/M3
04 - 0.1 MG/M3
05 - 0.5 MG/M3
06 - 0.5 MG/M3
07 - 1.0 MG/M3
08 - 1.0 MG/M3
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 744
Gallium oxide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05202-03
C62271
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/02/1989
BN
12024-21-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - .12 MG/M3
04 - .12 MG/M3
05 - .48 MG/M3
06 - .48 MG/M3
07 - 4.8 MG/M3
08 - 4.8 MG/M3
09 - 24 MG/M3
10 - 24 MG/M3
11 - 48 MG/M3
12 - 48 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 745
Gallium oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05202-04
C62271
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/03/1989
BN
12024-21-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - .12 MG/M3
04 - .12 MG/M3
05 - .48 MG/M3
06 - .48 MG/M3
07 - 4.8 MG/M3
08 - 4.8 MG/M3
09 - 24 MG/M3
10 - 24 MG/M3
11 - 48 MG/M3
12 - 48 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 746
Endocrine disruptor (Genistein)
TEST:
ROUTE:
TDMS #:
NTP #:
MULTIGEN CHRONIC
FEED
99930-91
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
01/04/1999
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F0 0 PPM
02 - F0 5 PPM
03 - F0 100 PPM
04 - F0 500 PPM
05 - F0 0 PPM
06 - F0 5 PPM
07 - F0 100 PPM
08 - F0 500 PPM
09 - F1 0 PPM
10 - F1 5 PPM
11 - F1 100 PPM
12 - F1 500 PPM
13 - F1 0 PPM
14 - F1 5 PPM
15 - F1 100 PPM
16 - F1 500 PPM
17 - F2 0 PPM
18 - F2 5 PPM
19 - F2 100 PPM
20 - F2 500 PPM
21 - F2 0 PPM
22 - F2 5 PPM
23 - F2 100 PPM
24 - F2 500 PPM
25 - F3 0 PPM
26 - F3/5PPM TO CTL
27 - F3/100PPM TO CTL
28 - F3/500PPM TO CTL
29 - F3 0 PPM
30 - F3/5PPM TO CTL
31 - F3/100PPM TO CTL
32 - F3/500PPM TO CTL
33 - F4 0 PPM
34 - F4/5PPM TO CTL
35 - F4/100PPM TO CTL
36 - F4/500PPM TO CTL
37 - F4 0 PPM
38 - F4/5PPM TO CTL
39 - F4/100PPM TO CTL
40 - F4/500PPM TO CTL
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 747
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
MULTIGEN CHRONIC
FEED
99930-92
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
03/06/1999
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1 0 PPM
02 - F1 5PPM
03 - F1 100PPM
04 - F1 500PPM
05 - F1 5PPM/CTL
06 - F1 100PPM/CTL
07 - F1 500PPM/CTL
08 - F1 0PPM
09 - F1 5PPM
10 - F1 100PPM
11 - F1 500PPM
12 - F1 5PPM/CTL
13 - F1 100PPM/CTL
14 - F1 500PPM/CTL
15 - F3 0 PPM
16 - F3 5PPM TO CTL
17 - F3 100PPM TO CTL
18 - F3 500PPM TOCTL
19 - F3 0 PPM
20 - F3 5PPM TO CTL
21 - F3 100PPM TO CTL
22 - F3 500PPM TO CTL
V
T
T
T
T
T
T
V
T
T
T
T
T
T
V
T
T
T
V
T
T
T
F
F
F
F
F
F
F
M
M
M
M
M
M
M
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 748
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99930-93
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
04/19/1999
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F3 0 PPM
02 - F3 5PPM TO CTL
03 - F3 100PPM TO CTL
04 - F3 500PPM TO CTL
05 - F3 0PPM
06 - F3 5PPM TO CTL
07 - F3 100PPM TO CTL
08 - F3 500PPM TO CTL
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 749
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99930-94
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
03/06/1999
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1 0PPM
02 - F1 5PPM
03 - F1 100PPM
04 - F1 500PPM
05 - F1 5PPM/CTL
06 - F1 100PPM/CTL
07 - F1 500PPM/CTL
08 - F1 0PPM
09 - F1 5PPM
10 - F1 100PPM
11 - F1 500PPM
12 - F1 5PPM/CTL
13 - F1 100PPM/CTL
14 - F1 500PPM/CTL
V
T
T
T
T
T
T
V
T
T
T
T
T
T
F
F
F
F
F
F
F
M
M
M
M
M
M
M
(UNSPECIFIED)
Page 750
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99930-95
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
08/02/1999
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F4 0 PPM
02 - F4/5PPM TO CTL
03 - F4/100PPM TO CTL
04 - F4/500PPM TO CTL
05 - F4 0 PPM
06 - F4/5PPM TO CTL
07 - F4/100PPM TO CTL
08 - F4/500PPM TO CTL
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 751
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99930-96
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
04/19/1999
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F3 0 PPM
02 - F3/5PPM TO CTL
03 - F3/100PPM TO CTL
04 - F3/500PPM TO CTL
05 - F3 0 PPM
06 - F3/5PPM TO CTL
07 - F3/100PPM TO CTL
08 - F3/500PPM TO CTL
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 752
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99930-97
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
01/04/1999
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F2 0 PPM
02 - F2 5 PPM
03 - F2 100 PPM
04 - F2 500 PPM
05 - F2 0 PPM
06 - F2 5 PPM
07 - F2 100 PPM
08 - F2 500 PPM
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 753
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99930-98
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
09/23/1998
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1 0 PPM
02 - F1 5 PPM
03 - F1 100 PPM
04 - F1 500 PPM
05 - F1 0 PPM
06 - F1 5 PPM
07 - F1 100 PPM
08 - F1 500 PPM
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 754
Endocrine disruptor (Genistein) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99930-99
MG96005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
07/14/1998
NR
446-72-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F0 0 PPM
02 - F0 5 PPM
03 - F0 100 PPM
04 - F0 500 PPM
05 - F0 0 PPM
06 - F0 5 PPM
07 - F0 100 PPM
08 - F0 500 PPM
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 755
Ginkgo biloba extract
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99031-01
C99031
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/09/2004
BC
90045-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 62.5 MG/KG
04 - 62.5 MG/KG
05 - 125 MG/KG
06 - 125 MG/KG
07 - 250 MG/KG
08 - 250 MG/KG
09 - 500 MG/KG
10 - 500 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 756
Ginkgo biloba extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99031-02
C99031
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/11/2004
BC
90045-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 125 MG/KG
04 - 125 MG/KG
05 - 250 MG/KG
06 - 250 MG/KG
07 - 500 MG/KG
08 - 500 MG/KG
09 - 1000 MG/KG
10 - 1000 MG/KG
11 - 2000 MG/KG
12 - 2000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 757
Ginkgo biloba extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99031-03
C99031
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/23/2005
BC
90045-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 100 mg/kg
04 - 100 mg/kg
05 - 300 mg/kg
06 - 300 mg/kg
07 - 1000 mg/kg
08 - 1000 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 758
Ginkgo biloba extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99031-04
C99031
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/17/2005
BC
90045-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 200 mg/kg
04 - 200 mg/kg
05 - 600 mg/kg
06 - 600 mg/kg
07 - 2000 mg/kg
08 - 2000 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 759
Ginkgo biloba extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
99031-98
C99031
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/23/2005
BC
90045-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 100 MG/KG
04 - 100 MG/KG
05 - 300 MG/KG
06 - 300 MG/KG
07 - 1000 MG/KG
08 - 1000 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 760
Ginkgo biloba extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99031-99
C99031
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/09/2004
BC
90045-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 62.5 MG/KG
04 - 62.5 MG/KG
05 - 125 MG/KG
06 - 125 MG/KG
07 - 250 MG/KG
08 - 250 MG/KG
09 - 500 MG/KG
10 - 500 MG/KG
11 - 1000 MG/KG
12 - 1000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 761
Ginseng
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20005-01
C20005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/07/2002
BC
50647-08-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 762
Ginseng (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20005-02
C20005
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/07/2002
BC
50647-08-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 763
Ginseng (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20005-03
C20005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/10/2003
BC
50647-08-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1000 MG/KG
04 - 1000 MG/KG
05 - 2000 MG/KG
06 - 2000 MG/KG
07 - 3000 MG/KG
08 - 3000 MG/KG
09 - 4000 MG/KG
10 - 4000 MG/KG
11 - 5000 MG/KG
12 - 5000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
WATER
Page 764
Ginseng (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20005-04
C20005
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/12/2003
BC
50647-08-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1000 MG/KG
04 - 1000 MG/KG
05 - 2000 MG/KG
06 - 2000 MG/KG
07 - 3000 MG/KG
08 - 3000 MG/KG
09 - 4000 MG/KG
10 - 4000 MG/KG
11 - 5000 MG/KG
12 - 5000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
WATER
Page 765
Ginseng (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20005-05
C20005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/21/2004
BC
50647-08-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1250 MG/KG
04 - 1250 MG/KG
05 - 2500 MG/KG
06 - 2500 MG/KG
07 - 5000 MG/KG
08 - 5000 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 766
Ginseng (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20005-06
C20005
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/09/2004
BC
50647-08-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1250 MG/KG
04 - 1250 MG/KG
05 - 2500 MG/KG
06 - 2500 MG/KG
07 - 5000 MG/KG
08 - 5000 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 767
Ginseng (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20005-99
C20005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/10/2003
BC
50647-08-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1000 MG/KG
04 - 1000 MG/KG
05 - 2000 MG/KG
06 - 2000 MG/KG
07 - 3000 MG/KG
08 - 3000 MG/KG
09 - 4000 MG/KG
10 - 4000 MG/KG
11 - 5000 MG/KG
12 - 5000 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
WATER
Page 768
Glucosamine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20319-01
C20319B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Zucker - Lean
01/06/2010
NR
3416-24-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle Vehicle
02 - Glucosam30 mg/kg
03 - Glucosam120mg/kg
04 - Glucosam300 mg/k
05 - Glucosam600 mg/k
V
T
T
T
T
M
M
M
M
M
FILTERED WATER
Page 769
Glucosamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20319-02
C20319B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Zucker - Obese
01/05/2010
NR
3416-24-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle Vehicle
02 - Glucosam30 mg/kg
03 - Glucosam120mg/kg
04 - Glucosam300 mg/k
05 - Glucosam600 mg/k
V
T
T
T
T
M
M
M
M
M
FILTERED WATER
Page 770
Glucosamine Hydrochloride + Chondroitin Sulfate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
09029-01
C09029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Zucker - Lean
10/19/2008
NR
GLUCOSCHONDN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - Chr24 & Glu30
03 - Chr96 & Glu120
04 - Chr240 & Glu300
05 - Chr480 & Glu600
V
T
T
T
T
M
M
M
M
M
FILTERED WATER
Page 771
Glucosamine Hydrochloride + Chondroitin Sulfate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
09029-02
C09029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Zucker - Obese
10/19/2008
NR
GLUCOSCHONDN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - Chr24 & Glu30
03 - Chr96 & Glu120
04 - Chr240 & Glu300
05 - Chr480 & Glu600
V
T
T
T
T
M
M
M
M
M
FILTERED WATER
Page 772
Glutaraldehyde
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05184-03
C55425B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/18/1989
BN
111-30-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPB
04 - 62.5 PPB
05 - 125 PPB
06 - 125 PPB
07 - 250 PPB
08 - 250 PPB
09 - 500 PPB
10 - 500 PPB
11 - 1000 PPB
12 - 1000 PPB
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 773
Glutaraldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05184-04
C55425B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/19/1989
BN
111-30-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPB
04 - 62.5 PPB
05 - 125 PPB
06 - 125 PPB
07 - 250 PPB
08 - 250 PPB
09 - 500 PPB
10 - 500 PPB
11 - 1000 PPB
12 - 1000 PPB
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 774
Glutaraldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05184-05
C55425C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/27/1994
BN
111-30-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 250 PPB
04 - 250 PPB
05 - 500 PPB
06 - 500 PPB
07 - 750 PPB
08 - 750 PPB
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 775
Glutaraldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05184-06
C55425C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/07/1994
BN
111-30-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPB
04 - 62.5 PPB
05 - 125 PPB
06 - 125 PPB
07 - 250 PPB
08 - 250 PPB
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 776
Glycidamide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20314-01
C20314
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
07/26/2004
NR
5694-00-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
13 - CONTROL
14 - 12.2 UG/ML
15 - 30.6 UG/ML
16 - 61.2 UG/ML
17 - 122 UG/ML
18 - 306 UG/ML
19 - CONTROL
20 - 12.2 UG/ML
21 - 30.6 UG/ML
22 - 61.2 UG/ML
23 - 122 UG/ML
24 - 306 UG/ML
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
WATER
Page 777
Glycidamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20314-02
C20314
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
07/26/2004
NR
5694-00-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
13 - CONTROL
14 - 12.2 UG/ML
15 - 30.6 UG/ML
16 - 61.2 UG/ML
17 - 122 UG/ML
18 - 306 UG/ML
19 - CONTROL
20 - 12.2 UG/ML
21 - 30.6 UG/ML
22 - 61.2 UG/ML
23 - 122 UG/ML
24 - 306 UG/ML
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
WATER
Page 778
Glycidamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20314-03
C20314
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
05/30/2005
NR
5694-00-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.70 GLYCID
02 - 0.35 GLYCID
03 - 0.175 GLYCID
04 - 0.0875 GLYCID
05 - CONTROL WATER
06 - 0.70 GLYCID
07 - 0.35 GLYCID
08 - 0.175 GLYCID
09 - 0.0875 GLYCID
10 - CONTROL WATER
T
T
T
T
V
T
T
T
T
V
M
M
M
M
M
F
F
F
F
F
FILTERED WATER
Page 779
Glycidamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20314-04
C20314
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
06/02/2005
NR
5694-00-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.70 GLYCID
02 - 0.35 GLYCID
03 - 0.175 GLYCID
04 - 0.0875 GLYCID
05 - CONTROL WATER
06 - 0.70 GLYCID
07 - 0.35 GLYCID
08 - 0.175 GLYCID
09 - 0.0875 GLYCID
10 - CONTROL WATER
T
T
T
T
V
T
T
T
T
V
M
M
M
M
M
F
F
F
F
F
FILTERED WATER
Page 780
Glyoxal
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88038-01
C88038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/10/1990
SO
107-22-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 1 MG/ML
04 - 1 MG/ML
05 - 2 MG/ML
06 - 2 MG/ML
07 - 4 MG/ML
08 - 4 MG/ML
09 - 8 MG/ML
10 - 8 MG/ML
11 - 16 MG/ML
12 - 16 MG/ML
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 781
Glyoxal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88038-02
C88038
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/10/1990
SO
107-22-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 1 MG/ML
04 - 1 MG/ML
05 - 2 MG/ML
06 - 2 MG/ML
07 - 4 MG/ML
08 - 4 MG/ML
09 - 8 MG/ML
10 - 8 MG/ML
11 - 16 MG/ML
12 - 16 MG/ML
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 782
Glyphosate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05191-03
C62011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/31/1988
SO
1071-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.3125%
04 - 0.3125%
05 - 0.625%
06 - 0.625%
07 - 1.25%
08 - 1.25%
09 - 2.5%
10 - 2.5%
11 - 5.0%
12 - 5.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 783
Glyphosate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05191-04
C62011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/13/1988
SO
1071-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.3125%
04 - 0.3125%
05 - 0.625%
06 - 0.625%
07 - 1.25%
08 - 1.25%
09 - 2.5%
10 - 2.5%
11 - 5.0%
12 - 5.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 784
Goldenseal root powder
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
99007-01
C99007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/21/2001
MB
GOLDENSEALRT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1560 PPM
03 - 3121 PPM
04 - 6250 PPM
05 - 12500 PPM
06 - 25000 PPM
07 - 50000 PPM
08 - VEHICLE CONTROL
09 - 1560 PPM
10 - 3121 PPM
11 - 6250 PPM
12 - 12500 PPM
13 - 25000 PPM
14 - 50000 PPM
V
T
T
T
T
T
T
V
T
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NTP-2000
Page 785
Goldenseal root powder (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
99007-02
C99007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/22/2001
MB
GOLDENSEALRT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1560 PPM
03 - 3121 PPM
04 - 6250 PPM
05 - 12500 PPM
06 - 25000 PPM
07 - 50000 PPM
08 - VEHICLE CONTROL
09 - 1560 PPM
10 - 3121 PPM
11 - 6250 PPM
12 - 12500 PPM
13 - 25000 PPM
14 - 50000 PPM
V
T
T
T
T
T
T
V
T
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NTP-2000
Page 786
Goldenseal root powder (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
99007-03
C99007B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/27/2002
SO
GOLDENSEALRT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3125 PPM
04 - 3125 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 787
Goldenseal root powder (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
99007-04
C99007B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/29/2002
SO
GOLDENSEALRT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3125 PPM
04 - 3125 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 788
Goldenseal root powder (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
99007-05
C99007B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/21/2003
SO
GOLDENSEALRT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3000 PPM
04 - 3000 PPM
05 - 9000 PPM
06 - 9000 PPM
07 - 25000 PPM
08 - 25000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 789
Goldenseal root powder (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
99007-06
C99007B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/12/2003
SO
GOLDENSEALRT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3000 PPM
04 - 3000 PPM
05 - 9000 PPM
06 - 9000 PPM
07 - 25000 PPM
08 - 25000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 790
Green Tea Extract
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20203-01
C20203
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
04/17/2006
BC
GREENTEAEXTR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 791
Green Tea Extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20203-02
C20203
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/19/2006
BC
GREENTEAEXTR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 792
Green Tea Extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20203-03
C20203
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
07/18/2007
BC
GREENTEAEXTR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 100 mg/kg
04 - 100 mg/kg
05 - 300 mg/kg
06 - 300 mg/kg
07 - 1000 mg/kg
08 - 1000 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
Sterile Water
Page 793
Green Tea Extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20203-04
C20203
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/09/2007
BC
GREENTEAEXTR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 30 mg/kg
04 - 30 mg/kg
05 - 100 mg/kg
06 - 100 mg/kg
07 - 300 mg/kg
08 - 300 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
Sterile Water
Page 794
Green Tea Extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20203-99
C20203
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
04/17/2006
BC
GREENTEAEXTR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/gkg
07 - 250 mg/kg
08 - 250 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 795
Gum Guggul Extract
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
GAVAGE
20605-01
C20605
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/23/2009
BC
GUMGUGGULEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 796
Gum Guggul Extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
GAVAGE
20605-02
C20605
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/30/2009
BC
GUMGUGGULEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 15.5 mg/kg
04 - 15.5 mg/kg
05 - 31 mg/kg
06 - 31 mg/kg
07 - 62.5 mg/kg
08 - 62.5 mg/kg
09 - 125 mg/kg
10 - 125 mg/kg
11 - 250 mg/kg
12 - 250 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 797
Gum Guggul Extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20605-98
C20605
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/30/2009
BC
GUMGUGGULEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 15.5 mg/kg
04 - 15.5 mg/kg
05 - 31 mg/kg
06 - 31 mg/kg
07 - 62.5 mg/kg
08 - 62.5 mg/kg
09 - 125 mg/kg
10 - 125 mg/kg
11 - 250 mg/kg
12 - 250 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 798
Gum Guggul Extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20605-99
C20605
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/23/2009
BC
GUMGUGGULEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 799
General Universal Download
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05050-07
C12345A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
(NOT DEFINED)
HZ
C12345A
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 800
General Universal Download (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05050-08
C12345A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(NOT DEFINED)
HZ
C12345A
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 801
Gum Guggul 2.5% granules
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
20701-99
IM20701
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/02/2007
VC
GUMGUGGULEXT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 31.25 mg/kg
03 - 62.5 mg/kg
04 - 125 mg/kg
05 - 250 mg/kg
06 - 500 mg/kg
07 - CPS 50 mg/kg
V
T
T
T
T
T
P
F
F
F
F
F
F
F
CORN OIL
Page 802
PHOSPHATE BUFFERED SALINE
HC Yellow 4
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05057-01
C56019
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/12/1983
MA
59820-43-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATED 61 UM
02 - 0.25% 61LM
03 - 0.5% 61HM
04 - UNTREATED 61UF
05 - 0.5% 61LF
06 - 1.0% 61HF
U
T
T
U
T
T
M
M
M
F
F
F
NIH-07
Page 803
HC Yellow 4 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05057-02
C56019
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/16/1983
MA
59820-43-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATED 61UM
02 - 0.5% 61LM
03 - 1.O% 61HM
04 - UNTREATED 61UF
05 - 0.5% 61LF
06 - 1.0% 61HF
U
T
T
U
T
T
M
M
M
F
F
F
NIH-07
Page 804
Hexachlorobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
98004-01
C98004
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/10/2001
BC
118-74-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.03 MG/KG
03 - 0.1 MG/KG
04 - 0.3 MG/KG
05 - 1.0 MG/KG
06 - 3.0 MG/KG
07 - 10.0 MG/KG
08 - 25.0 MG/KG
V
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 805
Hexachlorobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
98004-99
C98004
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
01/11/2001
BC
118-74-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.03 MG/KG
03 - 25 MG/KG
V
T
T
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 806
Hexachloro-1,3-butadiene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05115-02
C99854A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/05/1985
MB
87-68-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 100 PPM H-10
03 - 1.0 PPM H-6
04 - 3 PPM H-7
05 - 10 PPM H-8
06 - 30 PPM H-9
07 - VEHICLE CONTROL
08 - 100 PPM H-10
09 - 1.0 PPM H-6
10 - 3 PPM H-7
11 - 10 PPM H-8
12 - 30 PPM H-9
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 807
Hexachlorocyclopentadiene
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05114-01
C55607B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/02/1985
BN
77-47-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.01 PPM
04 - 0.01 PPM
05 - 0.05 PPM
06 - 0.05 PPM
07 - 0.2 PPM
08 - 0.2 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 808
Hexachlorocyclopentadiene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05114-02
C55607B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/18/1985
BN
77-47-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.01 PPM
04 - 0.01 PPM
05 - 0.05 PPM
06 - 0.05 PPM
07 - 0.2 PPM
08 - 0.2 PPM
09 - 0.2 PPMSE33
10 - 0.2 PPMSE65
11 - 0.5 PPMSE26
12 - 0.5 PPMSE42
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
M
M
M
AIR
Page 809
Hexachloroethane
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05028-01
C04604B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/01/1982
MA
67-72-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE MALE
02 - VEHICLE FEMALE
03 - .01 G/KG LM
04 - .02 G/KG HM
05 - .08 G/KG LF
06 - .16 G/KG HF
V
V
T
T
T
T
M
F
M
M
F
F
CORN OIL
Page 810
2,4-Hexadienal
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
93023-01
C93023
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/20/1995
MB
142-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/KG
02 - 3.0 MG/KG
03 - 9.0 MG/KG
04 - 27.0 MG/KG
05 - 80.0 MG/KG
06 - 240.0 MG/KG
07 - 0.0 MG/KG
08 - 3.0 MG/KG
09 - 9.0 MG/KG
10 - 27.0 MG/KG
11 - 80.0 MG/KG
12 - 240.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 811
2,4-Hexadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
93023-02
C93023
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/21/1995
MB
142-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/KG
02 - 3.0 MG/KG
03 - 9.0 MG/KG
04 - 27.0 MG/KG
05 - 80.0 MG/KG
06 - 240.0 MG/KG
07 - 0.0 MG/KG
08 - 3.0 MG/KG
09 - 9.0 MG/KG
10 - 27.0 MG/KG
11 - 80.0 MG/KG
12 - 240.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 812
2,4-Hexadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93023-03
C93023B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/05/1996
SO
142-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 7.5 MG/KG/DY
04 - 7.5 MG/KG/DY
05 - 15 MG/KG/DY
06 - 15 MG/KG/DY
07 - 30 MG/KG/DY
08 - 30 MG/KG/DY
09 - 60 MG/KG/DY
10 - 60 MG/KG/DY
11 - 120 MG/KG/DY
12 - 120 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 813
2,4-Hexadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93023-04
C93023B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/07/1996
SO
142-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 7.5 MG/KG/DY
04 - 7.5 MG/KG/DY
05 - 15 MG/KG/DY
06 - 15 MG/KG/DY
07 - 30 MG/KG/DY
08 - 30 MG/KG/DY
09 - 60 MG/KG/DY
10 - 60 MG/KG/DY
11 - 120 MG/KG/DY
12 - 120 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 814
2,4-Hexadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
93023-05
C93023B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/05/1996
SO
142-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 7.5 MG/KG/DY
04 - 7.5 MG/KG/DY
05 - 15 MG/KG/DY
06 - 15 MG/KG/DY
07 - 30 MG/KG/DY
08 - 30 MG/KG/DY
09 - 60 MG/KG/DY
10 - 60 MG/KG/DY
11 - 120 MG/KG/DY
12 - 120 MG/KG/DY
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 815
2,4-Hexadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
93023-06
C93023B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/11/1997
SO
142-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 22.5 MG/KG/DY
04 - 22.5 MG/KG/DY
05 - 45 MG/KG/DY
06 - 45 MG/KG/DY
07 - 90 MG/KG/DY
08 - 90 MG/KG/DY
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 816
2,4-Hexadienal (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
93023-07
C93023B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/25/1997
SO
142-83-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 30 MG/KG/DY
04 - 30 MG/KG/DY
05 - 60 MG/KG/DY
06 - 60 MG/KG/DY
07 - 120 MG/KG/DY
08 - 120 MG/KG/DY
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 817
1,6-Hexanediamine dihydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05116-05
C61405A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/02/1987
BC
6055-52-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/M3
02 - 0 MG/M3 MATING
03 - 0 MG/M3
04 - 0 MG/M3 MATING
05 - 1.6 MG/M3
06 - 1.6MG/M3 MATING
07 - 1.6 MG/M3
08 - 1.6MG/M3 MATING
09 - 5 MG/M3
10 - 5 MG/M3 MATING
11 - 5 MG/M3
12 - 5 MG/M3 MATING
13 - 16 MG/M3
14 - 16 MG/M3 MATING
15 - 16 MG/M3
16 - 16 MG/M3 MATING
17 - 50 MG/M3
18 - 50 MG/M3 MATING
19 - 50 MG/M3
20 - 50 MG/M3 MATING
21 - 160 MG/M3
22 - 160MG/M3 MATING
23 - 160 MG/M3
24 - 160MG/M3 MATING
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
AIR
Page 818
1,6-Hexanediamine dihydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05116-06
C61405A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/09/1987
BC
6055-52-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/M3
02 - 0 MG/M3 MATING
03 - 0 MG/M3
04 - 0 MG/M3 MATING
05 - 1.6 MG/M3
06 - 1.6MG/M3 MATING
07 - 1.6 MG/M3
08 - 1.6MG/M3 MATING
09 - 5 MG/M3
10 - 5 MG/M3 MATING
11 - 5 MG/M3
12 - 5 MG/M3 MATING
13 - 16 MG/M3
14 - 16 MG/M3 MATING
15 - 16 MG/M3
16 - 16 MG/M3 MATING
17 - 50 MG/M3
18 - 50 MG/M3 MATING
19 - 50 MG/M3
20 - 50 MG/M3 MATING
21 - 160 MG/M3
22 - 160MG/M3 MATING
23 - 160 MG/M3
24 - 160MG/M3 MATING
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
AIR
Page 819
n-Hexane
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05137-01
C60571
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/28/1986
BNL
110-54-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL NEURO
03 - CONTROL
04 - CONTROL NEURO
05 - 1000 PPM CONT
06 - 1000 PPM CON NEU
07 - 1000 PPM CONT
08 - 1000 PPM CON NEU
09 - 500 PPM
10 - 500 PPM NEURO
11 - 500 PPM
12 - 500 PPM NEURO
13 - 1000 PPM
14 - 1000 PPM NEURO
15 - 1000 PPM
16 - 1000 PPM NEURO
17 - 4000 PPM
18 - 4000 PPM NEURO
19 - 4000 PPM
20 - 4000 PPM NEURO
21 - 10000PPM
22 - 10000PPM NEURO
23 - 10000PPM
24 - 10000PPM NEURO
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
AIR
Page 820
Hydroquinone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05040-01
C55834B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/14/1982
BS
123-31-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 25 MG/KG
03 - 50 MG/KG
04 - VEHICLE CONTROL
05 - 25 MG/KG
06 - 50 MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
WATER
Page 821
Hydroquinone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05040-02
C55834B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/30/1982
BS
123-31-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 50 MG/KG
03 - 100MG/KG
04 - VEHICLE CONTROL
05 - 50 MG/KG
06 - 100MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
WATER
Page 822
2-Hydroxy-4-methoxybenzophenone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05112-07
C60957A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/13/1987
MA
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3125 PPM
04 - 3125 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 823
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05112-08
C60957A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/08/1987
MA
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3125 PPM
04 - 3125 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 824
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
05112-09
C60957B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/11/1987
MA
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25.0 MG/KG
06 - 25.0 MG/KG
07 - 50.0 MG/KG
08 - 50.0 MG/KG
09 - 100.0 MG/KG
10 - 100.0 MG/KG
11 - 200.0 MG/KG
12 - 200.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 825
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
05112-10
C60957B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/06/1987
MA
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 22.75 MG/KG
04 - 22.75 MG/KG
05 - 45.5 MG/KG
06 - 45.5 MG/KG
07 - 91.0 MG/KG
08 - 91.0 MG/KG
09 - 182.0 MG/KG
10 - 182.0 MG/KG
11 - 364.0 MG/KG
12 - 364.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 826
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
FEED
10260-01
C10260
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/08/2010
BC
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm Male
02 - 0 ppm Female
03 - 1000 ppm Male
04 - 1000 ppm Female
05 - 3000 ppm Male
06 - 3000 ppm Female
07 - 10000 ppm Male
08 - 10000 ppm Female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 827
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
10260-02
C10260
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
07/15/2010
BC
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 0 ppm
03 - 1000 ppm
04 - 1000 ppm
05 - 3000 ppm
06 - 3000 ppm
07 - 10000 ppm
08 - 10000 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 828
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10260-96
C10260
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/18/2010
BC
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm FemalePup
02 - 1000ppmFemalePup
03 - 3000ppmFemalePup
04 - 10000ppmFmalePup
V
T
T
T
F
F
F
F
NIH-07 (IRRADIATED)
Page 829
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10260-97
C10260
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/18/2010
BC
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm MalePup
02 - 1000ppm MalePup
03 - 3000ppm MalePup
04 - 10000ppm MalePup
V
T
T
T
M
M
M
M
NIH-07 (IRRADIATED)
Page 830
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10260-98
C10260
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/18/2010
BC
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm DamLac
02 - 1000 ppm DamLac
03 - 3000 ppm DamLac
04 - 10000 ppm DamLac
V
T
T
T
F
F
F
F
NIH-07 (IRRADIATED)
Page 831
2-Hydroxy-4-methoxybenzophenone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
10260-99
C10260
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/26/2010
BC
131-57-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm DamGes
02 - 1000 ppm DamGes
03 - 3000 ppm DamGes
04 - 10000 ppm DamGes
V
T
T
T
F
F
F
F
NIH-07 (IRRADIATED)
Page 832
5-(Hydroxymethyl)-2-furfural
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
95011-01
C95011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/18/1996
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 94 MG/KG
04 - 94 MG/KG
05 - 188 MG/KG
06 - 188 MG/KG
07 - 375 MG/KG
08 - 375 MG/KG
09 - 750 MG/KG
10 - 750 MG/KG
11 - 1500 MG/KG
12 - 1500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 833
5-(Hydroxymethyl)-2-furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
95011-02
C95011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/19/1996
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 94 MG/KG
04 - 94 MG/KG
05 - 188 MG/KG
06 - 188 MG/KG
07 - 375 MG/KG
08 - 375 MG/KG
09 - 750 MG/KG
10 - 750 MG/KG
11 - 1500 MG/KG
12 - 1500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 834
5-(Hydroxymethyl)-2-furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95011-03
C95011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/07/1997
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 94 MG/KG
04 - 94 MG/KG
05 - 188 MG/KG
06 - 188 MG/KG
07 - 375 MG/KG
08 - 375 MG/KG
09 - 750 MG/KG
10 - 750 MG/KG
11 - 1500 MG/KG
12 - 1500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 835
5-(Hydroxymethyl)-2-furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95011-04
C95011
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/15/1997
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 47 MG/KG
04 - 47 MG/KG
05 - 94 MG/KG
06 - 94 MG/KG
07 - 188 MG/KG
08 - 188 MG/KG
09 - 375 MG/KG
10 - 375 MG/KG
11 - 750 MG/KG
12 - 750 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 836
5-(Hydroxymethyl)-2-furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
95011-06
C95011B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/08/2001
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 188 MG/KG
04 - 188 MG/KG
05 - 375 MG/KG
06 - 375 MG/KG
07 - 750 MG/KG
08 - 750 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 837
5-(Hydroxymethyl)-2-furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
95011-07
C95011B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/06/2002
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 188 MG/KG
04 - 188 MG/KG
05 - 375 MG/KG
06 - 375 MG/KG
07 - 750 MG/KG
08 - 750 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 838
5-(Hydroxymethyl)-2-furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
95011-98
C95011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/07/1997
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 94 MG/KG
04 - 94 MG/KG
05 - 188 MG/KG
06 - 188 MG/KG
07 - 375 MG/KG
08 - 375 MG/KG
09 - 750 MG/KG
10 - 750 MG/KG
11 - 1500 MG/KG
12 - 1500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 839
5-(Hydroxymethyl)-2-furfural (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
95011-99
C95011
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/18/1996
BC
67-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1500 MG/KG
04 - 1500 MG/KG
V
V
T
T
M
F
M
F
DEIONIZED WATER
Page 840
Indium phosphide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88124-01
C88124
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/03/1995
BN
22398-80-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1.0 MG/M3
04 - 1.0 MG/M3
05 - 3.0 MG/M3
06 - 3.0 MG/M3
07 - 10.0 MG/M3
08 - 10.0 MG/M3
09 - 30.0 MG/M3
10 - 30.0 MG/M3
11 - 100.0 MG/M3
12 - 100.0 MG/M3
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 841
Indium phosphide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88124-02
C88124
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/03/1995
BN
22398-80-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1.0 MG/M3
04 - 1.0 MG/M3
05 - 3.0 MG/M3
06 - 3.0 MG/M3
07 - 10.0 MG/M3
08 - 10.0 MG/M3
09 - 30.0 MG/M3
10 - 30.0 MG/M3
11 - 100.0 MG/M3
12 - 100.0 MG/M3
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 842
Indium phosphide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88124-03
C88124
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/18/1996
BN
22398-80-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.03 MG/M3
04 - 0.03 MG/M3
05 - 0.1MG/M3 STOP
06 - 0.1MG/M3 STOP
07 - 0.3MG/M3 STOP
08 - 0.3MG/M3 STOP
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 843
Indium phosphide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88124-04
C88124
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/25/1996
BN
22398-80-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.03 MG/M3
04 - 0.03 MG/M3
05 - 0.1MG/M3 STOP
06 - 0.1MG/M3 STOP
07 - 0.3MG/M3 STOP
08 - 0.3MG/M3 STOP
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 844
Indole-3-carbinol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20006-01
C20006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/30/2004
SO
700-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 18.75 MG/KG
04 - 18.75 MG/KG
05 - 37.5 MG/KG
06 - 37.5 MG/KG
07 - 75 MG/KG
08 - 75 MG/KG
09 - 150 MG/KG
10 - 150 MG/KG
11 - 300 MG/KG
12 - 300 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 845
Indole-3-carbinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20006-02
C20006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/01/2004
SO
700-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 15.6 MG/KG
04 - 15.6 MG/KG
05 - 31.25 MG/KG
06 - 31.25 MG/KG
07 - 62.5 MG/KG
08 - 62.5 MG/KG
09 - 125 MG/KG
10 - 125 MG/KG
11 - 250 MG/KG
12 - 250 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 846
Indole-3-carbinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20006-03
C20006B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
03/14/2007
BC
700-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 75 mg/kg
04 - 75 mg/kg
05 - 150 mg/kg
06 - 150 mg/kg
07 - 300 mg/kg
08 - 300 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 847
Indole-3-carbinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20006-04
C20006B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/02/2007
BC
700-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 848
Indole-3-carbinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20006-98
C20006B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
03/14/2007
BC
700-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 75 mg/kg
04 - 150 mg/kg
05 - 300 mg/kg
06 - 300 mg/kg
V
V
T
T
T
T
M
F
M
M
M
F
CORN OIL
Page 849
Indole-3-carbinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20006-99
C20006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/30/2004
SO
700-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/KG
02 - 0.0 MG/KG
03 - 18.75 MG/KG
04 - 18.75 MG/KG
05 - 37.5 MG/KG
06 - 37.5 MG/KG
07 - 75 MG/KG
08 - 75 MG/KG
09 - 150 MG/KG
10 - 150 MG/KG
11 - 300 MG/KG
12 - 300 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 850
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05117-01
C61994A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/22/1985
BC
INIT/PROM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - DMBA 2.5/ACETONE
04 - DMBA 2.5/ACETONE
05 - DMBA 25 /ACETONE
06 - DMBA 25 /ACETONE
07 - DMBA 50 /ACETONE
08 - DMBA 50 /ACETONE
09 - DMBA2.5/COMPLETE
10 - DMBA2.5/COMPLETE
11 - TPA 5/ COMPLETE
12 - TPA 5/ COMPLETE
13 - BPO 20/ COMPLETE
14 - BPO 20/ COMPLETE
15 - DMBA 2.5/ TPA 5
16 - DMBA 2.5/ TPA 5
17 - DMBA 25/ TPA 5
18 - DMBA 25/ TPA 5
19 - DMBA 50/ TPA 5
20 - DMBA 50/ TPA 5
21 - DMBA 2.5/BPO 20
22 - DMBA 2.5/ BPO 20
23 - DMBA 25/ BPO 20
24 - DMBA 25/ BPO 20
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 851
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05117-02
C61994B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, CD-1 CRL
05/03/1985
BC
INIT/PROM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - DMBA0.25/ACETONE
04 - DMBA0.25/ACETONE
05 - DMBA 2.5/ACETONE
06 - DMBA 2.5/ACETONE
07 - DMBA 25/ACETONE
08 - DMBA 25/ACETONE
09 - DMBA2.5/COMPLETE
10 - DMBA2.5/COMPLETE
11 - TPA 5/ COMPLETE
12 - TPA 5/ COMPLETE
13 - BPO 20/ COMPLETE
14 - BPO 20/ COMPLETE
15 - DMBA0.25/ TPA 5
16 - DMBA0.25/ TPA 5
17 - DMBA 2.5/ TPA 5
18 - DMBA 2.5/ TPA 5
19 - DMBA 25/ TPA 5
20 - DMBA 25/ TPA 5
21 - DMBA 2.5/ BPO 20
22 - DMBA 2.5/ BPO 20
23 - DMBA 25/ BPO 20
24 - DMBA 25/ BPO 20
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 852
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05117-03
C61994C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SENCAR
05/09/1985
BC
INIT/PROM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - DMBA0.25/ACETONE
04 - DMBA0.25/ACETONE
05 - DMBA 2.5/ACETONE
06 - DMBA 2.5/ACETONE
07 - DMBA 25/ACETONE
08 - DMBA 25/ACETONE
09 - DMBA2.5/COMPLETE
10 - DMBA2.5/COMPLETE
11 - TPA 5/ COMPLETE
12 - TPA 5/ COMPLETE
13 - BPO 20/ COMPLETE
14 - BPO 20/ COMPLETE
15 - DMBA0.25/ TPA 5
16 - DMBA0.25/ TPA 5
17 - DMBA 2.5/ TPA 5
18 - DMBA 2.5/ TPA 5
19 - DMBA 25/ TPA 5
20 - DMBA 25/ TPA 5
21 - DMBA 2.5/ BPO 20
22 - DMBA 2.5/ BPO 20
23 - DMBA 25/ BPO 20
24 - DMBA 25/ BPO 20
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 853
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05117-04
C61994A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/22/1985
BC
INIT/PROM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - MNNG 100/ACETONE
04 - MNNG 100/ACETONE
05 - MNNG 500/ACETONE
06 - MNNG 500/ACETONE
07 - MNNG1000/ACETONE
08 - MNNG1000/ACETONE
09 - TPA 5 COMPLETE
10 - TPA 5 COMPLETE
11 - MNNG100/COMPLETE
12 - MNNG100/COMPLETE
13 - BPO 20 COMPLETE
14 - BPO 20 COMPLETE
15 - MNNG 100/BPO 20
16 - MNNG 100/BPO 20
17 - MNNG 500/BPO 20
18 - MNNG 500/BPO 20
19 - MNNG1000/BPO 20
20 - MNNG1000/BPO 20
21 - MNNG 100/TPA 5
22 - MNNG 100/TPA 5
23 - MNNG1000/TPA 5
24 - MNNG1000/TPA 5
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 854
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05117-05
C61994B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, CD-1 CRL
05/31/1985
BC
INIT/PROM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - MNNG 100/ACETONE
04 - MNNG 100/ACETONE
05 - MNNG 500/ACETONE
06 - MNNG 500/ACETONE
07 - MNNG1000/ACETONE
08 - MNNG1000/ACETONE
09 - TPA 5 COMPLETE
10 - TPA 5 COMPLETE
11 - MNNG100/COMPLETE
12 - MNNG100/COMPLETE
13 - BPO 20 COMPLETE
14 - BPO 20 COMPLETE
15 - MNNG 100/BPO 20
16 - MNNG 100/BPO 20
17 - MNNG 500/BPO 20
18 - MNNG 500/BPO 20
19 - MNNG1000/BPO 20
20 - MNNG1000/BPO 20
21 - MNNG 100/TPA 5
22 - MNNG 100/TPA 5
23 - MNNG1000/TPA 5
24 - MNNG1000/TPA 5
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 855
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05117-06
C61994C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SENCAR
06/06/1985
BC
INIT/PROM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - MNNG 100/ACETONE
04 - MNNG 100/ACETONE
05 - MNNG 500/ACETONE
06 - MNNG 500/ACETONE
07 - MNNG1000/ACETONE
08 - MNNG1000/ACETONE
09 - TPA 5 COMPLETE
10 - TPA 5 COMPLETE
11 - MNNG100/COMPLETE
12 - MNNG100/COMPLETE
13 - BPO 20 COMPLETE
14 - BPO 20 COMPLETE
15 - MNNG 100/BPO 20
16 - MNNG 100/BPO 20
17 - MNNG 500/BPO 20
18 - MNNG 500/BPO 20
19 - MNNG1000/BPO 20
20 - MNNG1000/BPO 20
21 - MNNG 100/TPA 5
22 - MNNG 100/TPA 5
23 - MNNG1000/TPA 5
24 - MNNG1000/TPA 5
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 856
Init/prom comparative mouse study (DMBA/TPA/BPO/MNNG) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
SKIN
05117-07
C61994C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SENCAR
10/16/1985
BC
INIT/PROM
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - DMBA0.25 /TPA 1
04 - DMBA0.25 /TPA 1
05 - DMBA 2.5 /TPA 1
06 - DMBA 2.5 /TPA 1
07 - DMBA 25 /TPA 1
08 - DMBA 25 /TPA 1
09 - TPA 1/ COMPLETE
10 - TPA 1/ COMPLETE
11 - MNNG 100 /TPA 1
12 - MNNG 100 /TPA 1
13 - MNNG1000 /TPA 1
14 - MNNG1000 /TPA 1
V
V
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 857
Insertional mutagenesis (Radiation Levels)
TEST:
ROUTE:
TDMS #:
NTP #:
8-WEEK
Whole Body Exposure
10329-01
C10329
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6.SJL
05/04/2010
BC
INSERTMUTRAD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 6.0 gray
02 - 6.5 gray
03 - 7.0 gray
04 - 7.5 gray
05 - 8.0 gray
06 - 8.5 gray
07 - 9.0 gray
08 - 9.5 gray
09 - 10.0 gray
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
(UNSPECIFIED)
Page 858
Insertional mutagenesis (Cryopreserved Murine Lin cells)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
INTV INJ
13036-01
C13036
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6
03/19/2013
BC
INSERTMUTCRYO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Mock 1A
02 - Mock 1B
03 - Mock 2A
04 - Mock 2B
05 - Mock 3
06 - Mock 4
07 - EFS SIN 5A
08 - EFS SIN 5B
09 - EFS SIN 6A
10 - EFS SIN 6B
11 - EFS SIN 7A
12 - EFS SIN 7B
13 - EFS SIN 8A
14 - EFS SIN 8B
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
PHOSPHATE BUFFERED SALINE
Page 859
Insertional mutagenesis II (SIN vector)
TEST:
ROUTE:
TDMS #:
NTP #:
8-WEEK
INTV INJ
08020-01
C08020
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6.SJL
01/05/2010
BC
INSERTMUT2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Primary SinVec
02 - Secondary SinVec
T
T
F
F
PHOSPHATE BUFFERED SALINE
Page 860
Insertional Mutagenesis - Definitive Vector Study
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
INTV INJ
10844-01
C10844
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6
07/15/2011
BC
INSERTMUT3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NTPMOCK
02 - LTR
03 - uORF LTR
04 - SIN
05 - EFS SIN
06 - P(-) SIN
V
T
T
T
T
T
F
F
F
F
F
F
PHOSPHATE BUFFERED SALINE
Page 861
Insertional mutagenesis (LTR/SIN vectors)
TEST:
ROUTE:
TDMS #:
NTP #:
12-week
INTV INJ
20703-01
C20703
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6.SJL
03/20/2007
BC
INSERTMUT
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - LTR-Vector
03 - SIN-Vector
V
T
T
F
F
F
Packaging Plasmids
Page 862
Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
SUBCUT
89006-01
C89006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/20/1990
SO
INTAZTCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 U 0 MG/KG
02 - 0 U 0 MG/KG
03 - 0 U 500MG/KG
04 - 0 U 500MG/KG
05 - 0 U 1K MG/KG
06 - 0 U 1K MG/KG
07 - 500 U 0 MG/KG
08 - 500 U 0 MG/KG
09 - 500 U 500MG/KG
10 - 500 U 500MG/KG
11 - 500 U 1K MG/KG
12 - 500 U 1K MG/KG
13 - 5000 U 0 MG/KG
14 - 5000 U 0 MG/KG
15 - 5000 U 500MG/KG
16 - 5000 U 500MG/KG
17 - 5000 U 1K MG/KG
18 - 5000 U 1K MG/KG
19 - 50 K U 0 MG/KG
20 - 50 K U 0 MG/KG
21 - 50 K U 500MG/KG
22 - 50 K U 500MG/KG
23 - 50 K U 1K MG/KG
24 - 50 K U 1K MG/KG
25 - 50 K U 0 MG/KG
26 - 50 K U 0 MG/KG
27 - 50 K U 1K MG/KG
28 - 50 K U 1K MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE, SERUM
Page 863
Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
89006-02
C89006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/08/1990
SO
INTAZTCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 30 MG/KG 500 U
04 - 30 MG/KG 500 U
05 - 60 MG/KG 500 U
06 - 60 MG/KG 500 U
07 - 120MG/KG 500 U
08 - 120MG/KG 500 U
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE, SERUM
Page 864
Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
89006-03
C89006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/15/1990
SO
INTAZTCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 30 MG/KG 5000 U
04 - 30 MG/KG 5000 U
05 - 60 MG/KG 5000 U
06 - 60 MG/KG 5000 U
07 - 120MG/KG 5000 U
08 - 120MG/KG 5000 U
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE, SERUM
Page 865
Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
89006-04
C89006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/14/1991
SO
INTAZTCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 30 MG/KG 5000 U
04 - 30 MG/KG 5000 U
05 - 60 MG/KG 5000 U
06 - 60 MG/KG 5000 U
07 - 120MG/KG 5000 U
08 - 120MG/KG 5000 U
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE, SERUM
Page 866
Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
89006-05
C89006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/21/1991
SO
INTAZTCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 30 MG/KG 500 U
04 - 30 MG/KG 500 U
05 - 60 MG/KG 500 U
06 - 60 MG/KG 500 U
07 - 120MG/KG 500 U
08 - 120MG/KG 500 U
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE, SERUM
Page 867
Interferon AD + ddC (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
SUBCUT
89030-01
C89030
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/15/1990
SO
INTDDCCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 0 MG/KG
02 - 0 0 MG/KG
03 - 0 DDC 250MG/KG
04 - 0 DDC 250MG/KG
05 - 0 DDC 1K MG/KG
06 - 0 DDC 1K MG/KG
07 - 500 IAD 0 MG/KG
08 - 500 IAD 0 MG/KG
09 - 5000 IAD 0 MG/KG
10 - 5000 IAD 0 MG/KG
11 - 5000DDAD250MG/KG
12 - 5000DDAD250MG/KG
13 - 5000DDAD1K MG/KG
14 - 5000DDAD1K MG/KG
15 - 50 IAD 0 MG/KG
16 - 50 IAD 0 MG/KG
17 - 500 IAD 0 MG/KG
18 - 500 IAD 0 MG/KG
19 - 500 DDAD250MG/KG
20 - 500 DDAD250MG/KG
21 - 500 DDAD1K MG/KG
22 - 500 DDAD1K MG/KG
23 - 500 IA 0 MG/KG
24 - 500 IA 0 MG/KG
25 - 500 DDCA1K MG/KG
26 - 500 DDCA1K MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE, SERUM
Page 868
Interferon A (AIDS Initiative)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SUBCUT
89006-08
C89001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/05/1990
SO
76543-88-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 500 U A/D
04 - 500 U A/D
05 - 5000 U A/D
06 - 5000 U A/D
07 - 5000 U A
08 - 5000 U A
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
SERUM
Page 869
Interferon A (AIDS Initiative) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SUBCUT
89006-09
C89001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/10/1990
SO
76543-88-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 500 U A/D
04 - 500 U A/D
05 - 5000 U A/D
06 - 5000 U A/D
07 - 5000 U A
08 - 5000 U A
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
SERUM
Page 870
Ionic Liquid: 1-Butyl-3-methylimidazolium Chloride
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
50050-01
C50050
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
04/25/2013
BC
79917-90-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 0.1 mg/mL male
04 - 0.1 mg/mL female
05 - 0.3 mg/mL male
06 - 0.3 mg/mL female
07 - 1 mg/mL male
08 - 1 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 871
Ionic Liquid: 1-Butyl-3-methylimidazolium Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
50050-02
C50050
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/23/2013
BC
79917-90-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 0.3 mg/mL male
04 - 0.3 mg/mL female
05 - 1 mg/mL male
06 - 1 mg/mL female
07 - 3 mg/mL male
08 - 3 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 872
Ionic Liquid: 1-Butyl-1-methylpyrrolidinium Chloride
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
50051-01
C05051
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/22/2013
BC
479500-35-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 0.3 mg/mL male
04 - 1 mg/mL female
05 - 1 mg/mL male
06 - 3 mg/mL female
07 - 3 mg/mL male
08 - 6 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 873
Ionic Liquid: 1-Butyl-1-methylpyrrolidinium Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
50051-02
C05051
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/20/2013
BC
479500-35-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 1 mg/mL male
04 - 1 mg/mL female
05 - 3 mg/mL male
06 - 3 mg/mL female
07 - 10 mg/mL male
08 - 6 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 874
Ionic Liquid: N-Butylpyridinium Chloride
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
50052-01
C05052
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/19/2013
BC
1124-64-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 0.3 mg/mL male
04 - 0.3 mg/mL female
05 - 1 mg/mL male
06 - 1 mg/mL female
07 - 3 mg/mL male
08 - 3 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 875
Ionic Liquid: N-Butylpyridinium Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
50052-02
C05052
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/17/2013
BC
1124-64-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 1 mg/mL male
04 - 1 mg/mL female
05 - 3 mg/mL male
06 - 3 mg/mL female
07 - 6 mg/mL male
08 - 6 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 876
Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
07018-01
C07018
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/09/2013
BC
65039-09-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 1 mg/mL male
04 - 1 mg/mL female
05 - 3 mg/mL male
06 - 3 mg/mL female
07 - 10 mg/mL male
08 - 10 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 877
Ionic Liquid: 1-Ethyl-3-methylimidazolium Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
07018-02
C07018
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/07/2013
BC
65039-09-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/mL male
02 - 0 mg/mL female
03 - 3 mg/mL male
04 - 3 mg/mL female
05 - 10 mg/mL male
06 - 10 mg/mL female
07 - 30 mg/mL male
08 - 30 mg/mL female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
WATER
Page 878
Ionic liquid Toxicity
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
05049-03
C05049
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
03/09/2009
MB
IONICLIQUIDS
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control Male
02 - 0.3mg/ml Bmim
03 - 1.0 mg/ml Bmim
04 - 3.0 mg/ml Bmim
05 - 3.0 mg/ml Emim
06 - 10.0 mg/ml Emim
07 - 30.0 mg/ml Emim
08 - 100.0 mg/ml Emim
09 - 1.0 mg/ml Bmpy
10 - 3.0 mg/ml Bmpy
11 - 6.0 mg/ml Bmpy
12 - 1.0 mg/ml NBuPy
13 - 3.0 mg/ml NBuPy
14 - 6.0 mg/ml NBuPy
15 - Control Female
16 - 0.3 mg/ml Bmim
17 - 1.0 mg/ml Bmim
18 - 3.0 mg/ml Bmim
19 - 3.0 mg/ml Emim
20 - 10.0 mg/ml Emim
21 - 30.0 mg/ml Emim
22 - 100.0 mg/ml Emim
23 - 1.0 mg/ml Bmpy
24 - 3.0 mg/ml Bmpy
25 - 6.0 mg/ml Bmpy
26 - 1.0 mg/ml NBuPy
27 - 3.0 mg/ml NBuPy
28 - 6.0 mg/ml NBuPy
V
T
T
T
T
T
T
T
T
T
T
T
T
T
V
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
F
F
TAP WATER
Page 879
Ionic liquid Toxicity (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
05049-04
C05049
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/12/2009
MB
IONICLIQUIDS
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control Male
02 - 1.0 mg/ml Bmim
03 - 3.0 mg/ml Bmim
04 - 6.0 mg/ml Bmim
05 - 3.0 mg/ml Emim
06 - 10.0 mg/ml Emim
07 - 30.0 mg/ml Emim
08 - 100.0 mg/ml Emim
09 - 3.0 mg/ml Bmpy
10 - 6.0 mg/ml Bmpy
11 - 10.0 mg/ml Bmpy
12 - 1.0 mg/ml NBuPy
13 - 3.0 mg/ml NBuPy
14 - 6.0 mg/ml NBuPy
15 - Control Female
16 - 1.0 mg/ml Bmim
17 - 3.0 mg/ml Bmim
18 - 6.0 mg/ml Bmim
19 - 3.0 mg/ml Emim
20 - 10.0 mg/ml Emim
21 - 30.0 mg/ml Emim
22 - 100.0 mg/ml Emim
23 - 3.0 mg/ml Bmpy
24 - 6.0 mg/ml Bmpy
25 - 10.0 mg/ml Bmpy
26 - 1.0 mg/ml NBuPy
27 - 3.0 mg/ml NBuPy
28 - 6.0 mg/ml NBuPy
V
T
T
T
T
T
T
T
T
T
T
T
T
T
V
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
F
F
TAP WATER
Page 880
Ionizing Radiation
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
Whole Body Exposure
10601-01
C10601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, AB6.129-Trp53
02/04/2009
IL
IONIZINGRAD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 Gy Y-IR
02 - 0 Gy Y-IR
03 - 3 Gy Y-IR
04 - 3 Gy Y-IR
05 - 6 Gy Y-IR
06 - 6 Gy Y-IR
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 881
(UNSPECIFIED)
Ionizing Radiation (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
Whole Body Exposure
10601-02
C10601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, CB6.129-Trp53
10/22/2008
IL
IONIZINGRAD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 Gy Y-IR
02 - 0 Gy Y-IR
03 - 3 Gy Y-IR
04 - 3 Gy Y-IR
05 - 6 Gy Y-IR
06 - 6 Gy Y-IR
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 882
(UNSPECIFIED)
Ionizing Radiation (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
Whole Body Exposure
10601-03
C10601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, RB6.129-Trp53
12/18/2008
IL
IONIZINGRAD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 Gy Y-IR
02 - 0 Gy Y-IR
03 - 3 Gy Y-IR
04 - 3 Gy Y-IR
05 - 6 Gy Y-IR
06 - 6 Gy Y-IR
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 883
(UNSPECIFIED)
Ionizing Radiation (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
Whole Body Exposure
10601-04
C10601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, D2B6.129-Trp53
12/11/2008
IL
IONIZINGRAD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 Gy Y-IR
02 - 0 Gy Y-IR
03 - 3 Gy Y-IR
04 - 3 Gy Y-IR
05 - 6 Gy Y-IR
06 - 6 Gy Y-IR
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 884
(UNSPECIFIED)
Ionizing Radiation (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
Whole Body Exposure
10601-05
C10601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, 129B6129Trp53
02/25/2009
IL
IONIZINGRAD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 Gy Y-IR
02 - 0 Gy Y-IR
03 - 3 Gy Y-IR
04 - 3 Gy Y-IR
05 - 6 Gy Y-IR
06 - 6 Gy Y-IR
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 885
(UNSPECIFIED)
Ionizing Radiation (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
39-WEEK
Whole Body Exposure
10601-06
C10601
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C3.B6.129-Trp53
04/02/2009
IL
IONIZINGRAD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 Gy Y-IR
02 - 0 Gy Y-IR
03 - 3 Gy Y-IR
04 - 3 Gy Y-IR
05 - 6 Gy Y-IR
06 - 6 Gy Y-IR
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 886
(UNSPECIFIED)
Isobutene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88070-01
C88070
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/20/1992
BN
115-11-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 4000 PPM
10 - 4000 PPM
11 - 8000 PPM
12 - 8000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 887
Isobutene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88070-02
C88070
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/21/1992
BN
115-11-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 4000 PPM
10 - 4000 PPM
11 - 8000 PPM
12 - 8000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 888
Isobutene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88070-03
C88070
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/11/1993
BN
115-11-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 500 PPM
04 - 500 PPM
05 - 2000 PPM
06 - 2000 PPM
07 - 8000 PPM
08 - 8000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 889
Isobutene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88070-04
C88070
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/04/1993
BN
115-11-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 500 PPM
04 - 500 PPM
05 - 2000 PPM
06 - 2000 PPM
07 - 8000 PPM
08 - 8000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 890
Isobutyl nitrite
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05185-01
C61052B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/16/1987
TR
542-56-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 10 PPM
03 - 25 PPM
04 - 75 PPM
05 - 150 PPM
06 - 300 PPM
07 - CONTROL
08 - 10 PPM
09 - 25 PPM
10 - 75 PPM
11 - 150 PPM
12 - 300 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 891
Isobutyl nitrite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05185-02
C61052B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/17/1987
TR
542-56-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 10 PPM
03 - 25 PPM
04 - 75 PPM
05 - 150 PPM
06 - 300 PPM
07 - CONTROL
08 - 10 PPM
09 - 25 PPM
10 - 75 PPM
11 - 150 PPM
12 - 300 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 892
Isobutyl nitrite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05185-03
C61052B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/08/1988
TR
542-56-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 37.5 PPM
03 - 75 PPM
04 - 150 PPM
05 - CONTROL
06 - 37.5 PPM
07 - 75 PPM
08 - 150 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
AIR
Page 893
Isobutyl nitrite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05185-04
C61052B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/05/1988
TR
542-56-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 37.5 PPM
03 - 75 PPM
04 - 150 PPM
05 - CONTROL
06 - 37.5 PPM
07 - 75 PPM
08 - 150 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
AIR
Page 894
Isobutyraldehyde
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
60968-01
C60968B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/16/1990
BN
78-84-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 895
Isobutyraldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
60968-02
C60968B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/09/1990
BN
78-84-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 500 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 1000 PPM
07 - 2000 PPM
08 - 2000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 896
Isoeugenol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88105-01
C88105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/16/2001
BC
97-54-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 897
Isoeugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88105-02
C88105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/18/2001
BC
97-54-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 898
Isoeugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88105-03
C88105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/22/2002
BC
97-54-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 75 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 150 MG/KG
07 - 300 MG/KG
08 - 300 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 899
Isoeugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88105-04
C88105
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/08/2002
BC
97-54-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 75 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 150 MG/KG
07 - 300 MG/KG
08 - 300 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 900
Isoeugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88105-99
C88105
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/16/2001
BC
97-54-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 901
Isoprene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05135-03
C61825
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/07/1988
BN
78-79-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 70 PPM
04 - 70 PPM
05 - 220 PPM
06 - 220 PPM
07 - 700 PPM
08 - 700 PPM
09 - 2200 PPM
10 - 2200 PPM
11 - 7000 PPM
12 - 7000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 902
Isoprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05135-04
C61825
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/09/1988
BN
78-79-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 70 PPM
04 - 70 PPM
05 - 220 PPM
06 - 220 PPM
07 - 700 PPM
08 - 700 PPM
09 - 2200 PPM
10 - 2200 PPM
11 - 7000 PPM
12 - 7000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 903
Isoprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
RESP BDY
05135-05
C61825C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/07/1988
BN
78-79-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 70 PPM
03 - 220 PPM
04 - 700 PPM
05 - 2200 PPM
06 - 7000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
AIR
Page 904
Isoprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
RESP BDY
05135-06
C61825C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/09/1988
BN
78-79-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 70 PPM
03 - 220 PPM
04 - 700 PPM
05 - 2200 PPM
06 - 7000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
AIR
Page 905
Isoprene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05135-07
C61825B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/24/1993
BN
78-79-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 220 PPM
04 - 220 PPM
05 - 700 PPM
06 - 700 PPM
07 - 7000 PPM
08 - 7000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 906
Immunotox Universal Download
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
05050-13
C12345D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
(NOT DEFINED)
HZ
C12345D
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 0.1 mg/kg
03 - 0.5 mg/kg
04 - 1.0 mg/kg
05 - 5.0 mg/kg
06 - 10 mg/kg
07 - CPS Pos Cont
V
T
T
T
T
T
P
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 907
Immunotox Universal Download (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
05050-14
C12345D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(NOT DEFINED)
HZ
C12345D
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle Control
02 - 156 mg/kg
03 - 312 mg/kg
04 - 625 mg/kg
05 - 1250 mg/kg
06 - 2500 mg/kg
07 - CPS Pos Cont
V
T
T
T
T
T
P
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 908
PHOSPHATE BUFFERED SALINE
Inhalation Universal Download
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05050-05
C12345
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/08/2012
HZ
1234-56-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 909
Inhalation Universal Download (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05050-06
C12345
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(NOT DEFINED)
HZ
1234-56-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 910
Inhalation Universal Download (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
RESP BDY
05050-98
C12345
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
(NOT DEFINED)
HZ
1234-56-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 0.1 mg/kg
03 - 0.5 mg/kg
04 - 1.0 mg/kg
05 - 5.0 mg/kg
06 - 10 mg/kg
07 - CPS Pos Cont
V
T
T
T
T
T
P
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 911
Kava kava extract
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20007-01
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/18/2003
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 912
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20007-02
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/18/2003
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 913
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20007-03
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/15/2003
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 914
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20007-04
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/17/2003
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 915
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20007-05
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/18/2004
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 G/KG
02 - 0.0 G/KG
03 - 0.1 G/KG
04 - 0.1 G/KG
05 - 0.3 G/KG
06 - 0.3 G/KG
07 - 1.0 G/KG
08 - 1.0 G/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 916
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20007-06
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/23/2004
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.25 G/KG
04 - 0.25 G/KG
05 - 0.5 G/KG
06 - 0.5 G/KG
07 - 1.0 G/KG
08 - 1.0 G/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 917
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20007-97
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/18/2004
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.1 G/KG
04 - 0.1 G/KG
05 - 0.3 G/KG
06 - 0.3 G/KG
07 - 1.0 G/KG
08 - 1.0 G/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 918
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20007-98
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/22/2003
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0.125 G/KG
03 - 0.25 G/KG
04 - 0.5 G/KG
05 - 1.0 G/KG
06 - 2.0 G/KG
V
T
T
T
T
T
M
M
M
M
M
M
CORN OIL
Page 919
Kava kava extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20007-99
C20007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/15/2003
BC
9000-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 920
Lauric acid diethanolamine condensate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
55323-01
C55323B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/13/1992
BC
120-40-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
11 - 400 MG/KG
12 - 400 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 921
Lauric acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
55323-02
C55323B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/15/1992
BC
120-40-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
07 - 200 MG/KG
08 - 200 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 800 MG/KG
12 - 800 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 922
Lauric acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
55323-03
C55323B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/14/1992
BC
120-40-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 923
Lauric acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
55323-04
C55323B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/30/1992
BC
120-40-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 100 MG/KG
04 - 100 MG/KG
05 - 200 MG/KG
06 - 200 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 924
Lead contaminated soil
TEST:
ROUTE:
TDMS #:
NTP #:
45-DAY
FEED
93006-01
C93006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/22/1993
BC
PBCONTAMSOIL
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CON-FEED
02 - CON-SOIL
03 - LA/FEED LOW
04 - LA/FEED MID
05 - LA/FEED HI
06 - LA/SOIL LOW
07 - LA/SOIL MID
08 - LA/SOIL HI
09 - LS/FEED
10 - LS/SOIL
11 - SOILS- LOW
12 - SOILS- MID
13 - SOILS- HI
U
V
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
AIN-76A
AIN-76A, UNTREATED
AIN-76A
Page 925
AIN-76A, UNTREATED
AIN-76A
AIN-76A, UNTREATED
AIN-76A
Lead ores
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
92001-01
C92001
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/11/1992
BC
LEADORES
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM 90 DAY
02 - 0 PPM 90 DAY
03 - 0 PPM 180 DAY
04 - LS 10PPM90 DAY
05 - LS 10PPM90 DAY
06 - LS 30PPM90 DAY
07 - LS 30PPM90 DAY
08 - LS100PPM90 DAY
09 - LS100PPM90 DAY
10 - LS100PPM180 DAY
11 - AK 10PPM90 DAY
12 - AK 30PPM90 DAY
13 - AK100PPM90 DAY
14 - MO 10PPM90 DAY
15 - MO 30PPM90 DAY
16 - MO100PPM90 DAY
17 - CO 10PPM90 DAY
18 - CO 30PPM90 DAY
19 - CO100PPM90 DAY
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
M
F
M
F
M
F
M
M
M
M
M
M
M
M
M
M
AIN-76A
Page 926
Leucomalachite green
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
93029-03
C93029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
11/26/1998
NR
129-73-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 91 PPM
03 - 272 PPM
04 - 543 PPM
06 - 0 PPM
07 - 91 PPM
08 - 272 PPM
09 - 543 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
(UNSPECIFIED)
Page 927
Leucomalachite green (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
93029-04
C93029
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
10/19/1998
NR
129-73-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 91 PPM
03 - 204 PPM
04 - 408 PPM
U
T
T
T
F
F
F
F
(UNSPECIFIED)
Page 928
Lipopolysaccharide (Airways Disease Project)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
RESP NAS
20705-01
C20705
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, 129S1/SvImJ
11/26/2007
BN
ECOLI_O111B4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - 7 ug/m3
V
T
M
M
AIR
Page 929
Lipopolysaccharide (Airways Disease Project) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
RESP NAS
20705-02
C20705
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
11/28/2007
BN
ECOLI_O111B4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - 7 ug/m3
V
T
M
M
AIR
Page 930
1020 Long Multiwalled Carbon Nanotube
TEST:
ROUTE:
TDMS #:
NTP #:
30-day
RESP BDY
07062-01
C07062
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/23/2011
BN
L-MWNT-1020
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 0.1 mg/m3
04 - 0.1 mg/m3
05 - 0.3 mg/m3
06 - 0.3 mg/m3
07 - 1 mg/m3
08 - 1 mg/m3
09 - 3 mg/m3
10 - 3 mg/m3
11 - 10 mg/m3
12 - 10 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 931
1020 Long Multiwalled Carbon Nanotube (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
30-day
RESP BDY
07062-02
C07062
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/30/2011
BN
L-MWNT-1020
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 0.1 mg/m3
04 - 0.1 mg/m3
05 - 0.3 mg/m3
06 - 0.3 mg/m3
07 - 1 mg/m3
08 - 1 mg/m3
09 - 3 mg/m3
10 - 3 mg/m3
11 - 10 mg/m3
12 - 10 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 932
Lovastatin
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
20503-99
IM20503
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/17/2005
VC
75330-75-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 0.5 mg/kg
03 - 2 mg/kg
04 - 5 mg/kg
05 - 20 mg/kg
06 - 50 mg/kg
07 - CPS Pos Cont
V
T
T
T
T
T
P
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 933
Magnetic fields (EMF)
TEST:
ROUTE:
TDMS #:
NTP #:
8-WEEK
MAG FLDS
89029-01
C89029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/01/1993
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 10 GAUSS
02 - 10 GAUSS
03 - 10 GAUSSINTER
04 - 10 GAUSSINTER
05 - 2 GAUSS
06 - 2 GAUSS
07 - .02 GAUSS
08 - .02 GAUSS
09 - UNTREAT.CONTROL
10 - UNTREAT.CONTROL
T
T
T
T
T
T
T
T
U
U
M
F
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 934
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
8-WEEK
MAG FLDS
89029-02
C89029
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/01/1993
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 10 GAUSS
02 - 10 GAUSS
03 - 10 GAUSSINTER
04 - 10 GAUSSINTER
05 - 2 GAUSS
06 - 2 GAUSS
07 - .02 GAUSS
08 - .02 GAUSS
09 - UNTREAT.CONTROL
10 - UNTREAT.CONTROL
T
T
T
T
T
T
T
T
U
U
M
F
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 935
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
MAG FLDS
89029-03
C89029B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, PIM
02/09/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 10 GAUSS
02 - 10 GAUSS
03 - 10 GAUSSINTER
04 - 10 GAUSSINTER
05 - 2 GAUSS
06 - 2 GAUSS
07 - 0.02 GAUSS
08 - 0.02 GAUSS
09 - SHAM CONTROL
10 - SHAM CONTROL
11 - 10 GAUSS
12 - 10 GAUSS
13 - 10 GAUSSINTER
14 - 10 GAUSSINTER
15 - 2 GAUSS
16 - 2 GAUSS
17 - 0.02 GAUSS
18 - 0.02 GAUSS
19 - SHAM CONTROL
20 - SHAM CONTROL
T
T
T
T
T
T
T
T
U
U
T
T
T
T
T
T
T
T
U
U
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 936
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
MAG FLDS
89029-04
C89029B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
02/09/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 10 GAUSS
02 - 10 GAUSS
03 - SHAM CONTROL
04 - SHAM CONTROL
05 - 10 GAUSS
06 - 10 GAUSS
07 - SHAM CONTROL
08 - SHAM CONTROL
T
T
U
U
T
T
U
U
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 937
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
MAG FLDS
89029-05
C89029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/26/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SHAM CONTROL
02 - SHAM CONTROL
03 - 0.02 GAUSS
04 - 0.02 GAUSS
05 - 2 GAUSS
06 - 2 GAUSS
07 - 10 GAUSS INTER.
08 - 10 GAUSS INTER.
09 - 10 GAUSS
10 - 10 GAUSS
11 - SHAM CONTROL
12 - SHAM CONTROL
13 - 0.02 GAUSS
14 - 0.02 GAUSS
15 - 2 GAUSS
16 - 2 GAUSS
17 - 10 GAUSS INTER.
18 - 10 GAUSS INTER.
19 - 10 GAUSS
20 - 10 GAUSS
U
U
T
T
T
T
T
T
T
T
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 938
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
MAG FLDS
89029-06
C89029
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/05/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SHAM CONTROL
02 - SHAM CONTROL
03 - 0.02 GAUSS
04 - 0.02 GAUSS
05 - 2 GAUSS
06 - 2 GAUSS
07 - 10 GAUSS INTER.
08 - 10 GAUSS INTER.
09 - 10 GAUSS
10 - 10 GAUSS
11 - SHAM CONTROL
12 - SHAM CONTROL
13 - 0.02 GAUSS
14 - 0.02 GAUSS
15 - 2 GAUSS
16 - 2 GAUSS
17 - 10 GAUSS INTER.
18 - 10 GAUSS INTER.
19 - 10 GAUSS
20 - 10 GAUSS
U
U
T
T
T
T
T
T
T
T
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 939
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
45-DAY
MAG FLDS
89029-07
C89029C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/10/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SHAM CONTROL
02 - SHAM CONTROL
03 - 0.02 GAUSS
04 - 0.02 GAUSS
05 - 2 GAUSS
06 - 2 GAUSS
07 - 10 GAUSS INTER.
08 - 10 GAUSS INTER.
09 - 10 GAUSS
10 - 10 GAUSS
11 - POSITIVE CONTROL
12 - POSITIVE CONTROL
U
U
T
T
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 940
ELECTROMAGNETIC FIELDS
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
45-DAY
MAG FLDS
89029-08
C89029C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/12/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SHAM CONTROL
02 - 0.02 GAUSS
03 - 2 GAUSS
04 - 10 GAUSS INTER.
05 - 10 GAUSS
06 - POSITIVE CONTROL
07 - SHAM CONTROL
08 - 0.02 GAUSS
09 - 2 GAUSS
10 - 10 GAUSS INTER.
11 - 10 GAUSS
12 - POSITIVE CONTROL
13 - SHAM CONTROL
14 - 0.02 GAUSS
15 - 2 GAUSS
16 - 10 GAUSS INTER.
17 - 10 GAUSS
18 - POSITIVE CONTROL
U
T
T
T
T
P
U
T
T
T
T
P
U
T
T
T
T
P
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
(UNSPECIFIED)
Page 941
ELECTROMAGNETIC FIELDS
(UNSPECIFIED)
ELECTROMAGNETIC FIELDS
(UNSPECIFIED)
ELECTROMAGNETIC FIELDS
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
MAG FLDS
89029-09
C89029
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/10/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SHAM CONTROL
02 - SHAM CONTROL
03 - 0.02 GAUSS
04 - 0.02 GAUSS
05 - 2 GAUSS
06 - 2 GAUSS
07 - 10 GAUSS INTER.
08 - 10 GAUSS INTER.
09 - 10 GAUSS
10 - 10 GAUSS
11 - POSITIVE CONTROL
12 - POSITIVE CONTROL
U
U
T
T
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
M
F
(UNSPECIFIED)
Page 942
ELECTROMAGNETIC FIELDS
Magnetic fields (EMF) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
MAG FLDS
89029-10
C89029
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/12/1994
TR
ELECTROMAG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SHAM CONTROL
02 - 0.02 GAUSS
03 - 2 GAUSS
04 - 10 GAUSS INTER.
05 - 10 GAUSS
06 - POSITIVE CONTROL
07 - SHAM CONTROL
08 - 0.02 GAUSS
09 - 2 GAUSS
10 - 10 GAUSS INTER.
11 - 10 GAUSS
12 - POSITIVE CONTROL
13 - SHAM CONTROL
14 - 0.02 GAUSS
15 - 2 GAUSS
16 - 10 GAUSS INTER.
17 - 10 GAUSS
18 - POSITIVE CONTROL
U
T
T
T
T
P
U
T
T
T
T
P
U
T
T
T
T
P
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
(UNSPECIFIED)
Page 943
ELECTROMAGNETIC FIELDS
(UNSPECIFIED)
ELECTROMAGNETIC FIELDS
(UNSPECIFIED)
ELECTROMAGNETIC FIELDS
Magnetic fields + DMBA initiation promotion
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
MAG FLDS
89029-11
C89029D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
07/29/1996
BN
EMF+DMBA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 10 DMBA CONTROL
02 - VEHICLE CONTROL
03 - 50 HZ/1G 10 DMBA
04 - 60 HZ/1G 10 DMBA
05 - 50 HZ/5G 10 DMBA
V
U
T
T
T
F
F
F
F
F
DMBA, SESAME OIL
SESAME OIL
DMBA, SESAME OIL
Page 944
Magnetic fields + DMBA initiation promotion (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
MAG FLDS
89029-12
C89029D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
08/14/1996
BN
EMF+DMBA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 20 DMBA CONTROL
02 - VEHICLE CONTROL
03 - 50 HZ/1G 20 DMBA
04 - 60 HZ/1G 20 DMBA
05 - 50 HZ/5G 20 DMBA
V
U
T
T
T
F
F
F
F
F
DMBA, SESAME OIL
SESAME OIL
DMBA, SESAME OIL
Page 945
Magnetic fields + DMBA initiation promotion (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
INIT/PROMOT
MAG FLDS
89029-13
C89029D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
03/04/1997
BN
EMF+DMBA
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 8 DMBA CONTROL
02 - 50 HZ/1G 8 DMBA
03 - 50 HZ/5G 8 DMBA
V
T
T
F
F
F
DMBA, SESAME OIL
Page 946
Ma Huang + caffeine combination
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20402-01
C20402
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/20/2004
BC
MAHUANGCOMBO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - M 312.5 MG/KG
03 - M 625 MG/KG
04 - M 1250 MG/KG
05 - CAF 15 MG/KG
06 - M312.5/ C15MG/KG
07 - M625/C15MG/KG
08 - M1250/ C15MG/KG
09 - CAF 30 MG/KG
10 - M312.5/ C30MG/KG
11 - M625/C30MG/KG
12 - M1250/ C30MG/KG
13 - CAF 45 MG/KG
14 - M312.5/ C45MG/KG
V
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 947
Malachite green
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
93005-03
C93005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/13/1999
NR
569-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 100 PPM
03 - 300 PPM
04 - 600 PPM
U
T
T
T
F
F
F
F
NIH-31
Page 948
Malachite green (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
93005-04
C93005
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
04/13/1999
NR
569-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 100 PPM
03 - 225 PPM
04 - 450 PPM
U
T
T
T
F
F
F
F
NIH-31
Page 949
Manganese sulfate monohydrate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05085-01
C61143B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/24/1984
BC
10034-96-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1500 PPM
03 - 5000 PPM
04 - 15000 PPM
05 - 0 PPM
06 - 1500 PPM
07 - 5000 PPM
08 - 15000 PPM
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 950
Manganese sulfate monohydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05085-02
C61143B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/08/1984
BC
10034-96-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 1500 PPM
03 - 5000 PPM
04 - 15000 PPM
05 - 0PPM
06 - 1500 PPM
07 - 5000 PPM
08 - 15000 PPM
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 951
Melamine + Cyanuric Acid combination
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
09074-01
C09074
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
07/07/2011
NR
MELCYANCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - MEL/CYA 0.63 M
03 - MEL/CYA 1.25 M
04 - MEL/CYA 2.5 M
05 - MEL/CYA 5.0 M
06 - MEL/CYA 10.0 M
07 - CONTROL FEMALE
08 - MEL/CYA 0.63 F
09 - MEL/CYA 1.25 F
10 - MEL/CYA 2.5 F
11 - MEL/CYA 5.0 F
12 - MEL/CYA 10.0 F
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.1% Carboxymethylcellulose
Page 952
Melatonin
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96013-01
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/25/2001
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 953
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96013-02
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, LONG-EVANS
07/24/2001
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 954
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
96013-03
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/28/2002
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 955
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
96013-04
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, LONG-EVANS
01/21/2002
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 956
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
96013-95
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/28/2002
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 957
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96013-96
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, LONG-EVANS
07/25/2001
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 958
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96013-97
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/26/2001
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 959
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96013-98
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, LONG-EVANS
07/26/2001
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 960
Melatonin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
96013-99
C96013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/27/2001
BC
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 5 UG/KG
04 - 5 UG/KG
05 - 50 UG/KG
06 - 50 UG/KG
07 - 5000 UG/KG
08 - 5000 UG/KG
09 - 50,000 UG/KG
10 - 50,000 UG/KG
11 - 200,000 UG/KG
12 - 200,000 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 961
2-Mercaptobenzimidazole
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05190-01
C60980B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/14/1988
TR
583-39-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 3.13 MG/M3
03 - 6.25 MG/M3
04 - 12.5 MG/M3
05 - 25.0 MG/M3
06 - 50.0 MG/M3
07 - CONTROL
08 - 3.13 MG/M3
09 - 6.25 MG/M3
10 - 12.5 MG/M3
11 - 25.0 MG/M3
12 - 50.0 MG/M3
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 962
2-Mercaptobenzimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05190-02
C60980B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/15/1988
TR
583-39-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 3.13 MG/M3
03 - 6.25 MG/M3
04 - 12.5 MG/M3
05 - 25.0 MG/M3
06 - 50.0 MG/M3
07 - CONTROL
08 - 3.13 MG/M3
09 - 6.25 MG/M3
10 - 12.5 MG/M3
11 - 25.0 MG/M3
12 - 50.0 MG/M3
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 963
Mercuric chloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05031-01
C60173
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/10/1983
IR
7487-94-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 5MG/KG MALE
03 - 10MG/KG MALE
04 - CONTROL FEMALE
05 - 5MG/KG FEMALE
06 - 10MG/KG FEMALE
V
T
T
V
T
T
M
M
M
F
F
F
DEIONIZED WATER
Page 964
Mercuric chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05031-02
C60173
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/04/1983
IR
7487-94-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 2.5MG/KGMALE
03 - 5 MG/KG MALE
04 - CONTROL FEMALE
05 - 2.5MG/KGFEMALE
06 - 5.0MG/KGFEMALE
V
T
T
V
T
T
M
M
M
F
F
F
DEIONIZED WATER
Page 965
Metal working fluids (Syntilo 1023)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20519-01
C20519
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/03/2008
BN
SYNTILO1023
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 966
Metal working fluids (Syntilo 1023) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20519-02
C20519
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/03/2008
BN
SYNTILO1023
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 967
Metal Working Fluids: CIMSTAR 3800
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20515-01
C20515
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
06/12/2006
BN
CIMSTAR3800
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 968
Metal Working Fluids: CIMSTAR 3800 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20515-02
C20515
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/12/2006
BN
CIMSTAR3800
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 969
Metal Working Fluids: CIMSTAR 3800 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20515-03
C20515
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
04/14/2008
BN
CIMSTAR3800
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 10 mg/m3
04 - 10 mg/m3
05 - 30 mg/m3
06 - 30 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 970
Metal Working Fluids: CIMSTAR 3800 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20515-04
C20515
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/05/2008
BN
CIMSTAR3800
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 10 mg/m3
04 - 10 mg/m3
05 - 30 mg/m3
06 - 30 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 971
Metal working fluids (Clearedge 6584)
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
RESP BDY
20517-02
C20517
TREATMENT GROUP
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(UNSPECIFIED)
BN
CLEAREDG6584
ROLE
SEX
Page 972
VEHICLE(S)
Metal working fluids (Trim SC210)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20516-01
C20516
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
08/14/2006
BN
TRIMSC210
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 973
Metal working fluids (Trim SC210) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20516-02
C20516
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/14/2006
BN
TRIMSC210
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 974
Metal Working Fluids: TRIM® VX
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20523-01
C20523
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
07/14/2008
BN
TRIMVX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 975
Metal Working Fluids: TRIM® VX (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20523-02
C20523
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/14/2008
BN
TRIMVX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 25 mg/m3
04 - 25 mg/m3
05 - 50 mg/m3
06 - 50 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
09 - 200 mg/m3
10 - 200 mg/m3
11 - 400 mg/m3
12 - 400 mg/m3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 976
Metal Working Fluids: TRIM® VX (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20523-03
C20523
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
07/20/2009
BN
TRIMVX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 10 mg/m3
04 - 10 mg/m3
05 - 30 mg/m3
06 - 30 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 977
Metal Working Fluids: TRIM® VX (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20523-04
C20523
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/03/2009
BN
TRIMVX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 10 mg/m3
04 - 10 mg/m3
05 - 30 mg/m3
06 - 30 mg/m3
07 - 100 mg/m3
08 - 100 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 978
Methacrylonitrile
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
FEED
80000-01
C88050
TREATMENT GROUP
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(UNSPECIFIED)
UNK
126-98-7
ROLE
SEX
Page 979
VEHICLE(S)
Methacrylonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
88050-01
C88050
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/06/1992
BC
126-98-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.3 G/L
04 - 0.3 G/L
05 - 0.6 G/L
06 - 0.6 G/L
07 - 1.2 G/L
08 - 1.2 G/L
09 - 2.4 G/L
10 - 2.4 G/L
11 - 4.8 G/L
12 - 4.8 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 980
Methacrylonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
88050-02
C88050
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/03/1992
BC
126-98-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.15 G/L
04 - 0.15 G/L
05 - 0.3 G/L
06 - 0.3 G/L
07 - 0.6 G/L
08 - 0.6 G/L
09 - 1.2 G/L
10 - 1.2 G/L
11 - 2.4 G/L
12 - 2.4 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 981
Methacrylonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88050-03
C88050
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/13/1992
BC
126-98-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 7.5 MG/KG
04 - 7.5 MG/KG
05 - 15.0 MG/KG
06 - 15.0 MG/KG
07 - 30.0 MG/KG
08 - 30.0 MG/KG
09 - 60.0 MG/KG
10 - 60.0 MG/KG
11 - 120.0 MG/KG
12 - 120.0 MG/KG
13 - 0 MG/KG 30 DAY
14 - 0 MG/KG 30 DAY
15 - 7.5MG/KG30 DAY
16 - 7.5MG/KG30 DAY
17 - 15 MG/KG30 DAY
18 - 15 MG/KG30 DAY
19 - 30 MG/KG30 DAY
20 - 30 MG/KG30 DAY
21 - 60 MG/KG30 DAY
22 - 60 MG/KG30 DAY
23 - 120MG/KG30 DAY
24 - 120MG/KG30 DAY
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 982
Methacrylonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88050-04
C88050
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/27/1992
BC
126-98-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3.0 MG/KG
08 - 3.0 MG/KG
09 - 6.0 MG/KG
10 - 6.0 MG/KG
11 - 12.0 MG/KG
12 - 12.0 MG/KG
13 - 0 MG/KG 30 DAY
14 - 0 MG/KG 30 DAY
15 - .75MG/KG30 DAY
16 - .75MG/KG30 DAY
17 - 1.5MG/KG30 DAY
18 - 1.5MG/KG30 DAY
19 - 3.0MG/KG30 DAY
20 - 3.0MG/KG30 DAY
21 - 6.0MG/KG30 DAY
22 - 6.0MG/KG30 DAY
23 - 12 MG/KG30 DAY
24 - 12 MG/KG30 DAY
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 983
Methacrylonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88050-05
C88050B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/30/1995
BC
126-98-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 10 MG/KG
06 - 10 MG/KG
07 - 30 MG/KG
08 - 30 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 984
Methacrylonitrile (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88050-06
C88050B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/16/1995
BC
126-98-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.5 MG/KG
04 - 1.5 MG/KG
05 - 3 MG/KG
06 - 3 MG/KG
07 - 6 MG/KG
08 - 6 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 985
Methapyrilene hydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
55550-01
C55550E
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/18/1991
MB
135-23-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 50 PPM
03 - 100 PPM
04 - 250 PPM
05 - 1000 PPM
06 - POSITIVE CONTROL
07 - NEGATIVE CONTROL
08 - CONTROL
09 - 50 PPM
10 - 100 PPM
11 - 250 PPM
12 - 1000 PPM
13 - POSITIVE CONTROL
14 - NEGATIVE CONTROL
V
T
T
T
T
P
N
V
T
T
T
T
P
N
M
M
M
M
M
M
M
M
M
M
M
M
M
M
NIH-07
Page 986
6-Methoxy-2-benzothiazolamine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05153-01
C61734
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/28/1986
MB
1747-60-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.025%
04 - 0.025%
05 - 0.05%
06 - 0.05%
07 - 0.1%
08 - 0.1%
09 - 0.2%
10 - 0.2%
11 - 0.4%
12 - 0.4%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 987
6-Methoxy-2-benzothiazolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05153-02
C61734
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/30/1986
MB
1747-60-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.025%
04 - 0.025%
05 - 0.05%
06 - 0.05%
07 - 0.1%
08 - 0.1%
09 - 0.2%
10 - 0.2%
11 - 0.4%
12 - 0.4%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 988
2-Methoxy-4-nitroaniline
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
06049-01
C06049
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/22/2009
BC
97-52-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0ppm
02 - 0.0ppm
03 - 625ppm
04 - 625ppm
05 - 1250ppm
06 - 1250ppm
07 - 2500ppm
08 - 2500ppm
09 - 5000ppm
10 - 5000ppm
11 - 10000ppm
12 - 10000ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 989
4-(6-Methyl-2-benzothiazolyl)-benzenamine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05140-03
C61745
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/15/1986
SO
92-36-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.00625%
04 - 0.00625%
05 - 0.0125%
06 - 0.0125%
07 - 0.025%
08 - 0.025%
09 - 0.05%
10 - 0.05%
11 - 0.1%
12 - 0.1%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 990
4-(6-Methyl-2-benzothiazolyl)-benzenamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05140-04
C61745
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/08/1986
SO
92-36-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - .0125%
04 - .0125%
05 - .025%
06 - .025%
07 - .05%
08 - .05%
09 - .1%
10 - .1%
11 - .2%
12 - .2%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 991
Methyl bromide
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05101-01
C04148B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/26/1984
BNL
74-83-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL INTERIM
02 - 10 PPM INTERIM
03 - 33 PPM INTERIM
05 - CONTROL INTERIM
06 - 10 PPM INTERIM
07 - 33 PPM INTERIM
08 - 100 PPM INTERIM
09 - CONTROL TERMINAL
10 - 10 PPM TERMINAL
11 - 33 PPM TERMINAL
12 - 100 PPM TERMINAL
13 - CONTROL TERMINAL
14 - 10 PPM TERMINAL
15 - 33 PPM TERMINAL
16 - 100 PPM TERMINAL
17 - CONTROL NEURO
18 - 10 PPM NEURO
19 - 33 PPM NEURO
20 - 100 PPM NEURO
21 - CONTROL NEURO
22 - 10 PPM NEURO
23 - 33 PPM NEURO
24 - 100 PPM NEURO
V
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
AIR
Page 992
Methylene bis(thiocyanate)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05215-03
C61916
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/24/1989
HR
6317-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.0 MG/KG
04 - 1.0 MG/KG
05 - 2.0 MG/KG
06 - 2.0 MG/KG
07 - 4.0 MG/KG
08 - 4.0 MG/KG
09 - 8.0 MG/KG
10 - 8.0 MG/KG
11 - 16.0 MG/KG
12 - 16.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 993
Methylene bis(thiocyanate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05215-04
C61916
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/21/1989
HR
6317-18-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1.0 MG/KG
04 - 1.0 MG/KG
05 - 2.0 MG/KG
06 - 2.0 MG/KG
07 - 4.0 MG/KG
08 - 4.0 MG/KG
09 - 8.0 MG/KG
10 - 8.0 MG/KG
11 - 16.0 MG/KG
12 - 16.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 994
Methylene blue trihydrate
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
91005-01
C91005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/04/1992
BC
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 995
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
91005-02
C91005
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/06/1992
BC
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 996
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
91005-03
C91005B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/05/1993
BC
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 997
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
91005-04
C91005B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/07/1993
BC
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 998
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
91005-05
C91005B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/05/1993
BC
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 999
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
91005-06
C91005B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/07/1993
BC
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1000
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
91005-07
C91005C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/26/2000
SO
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 5 MG/KG
04 - 5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1001
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
91005-08
C91005C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/10/2000
SO
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 2.5 MG/KG
04 - 2.5 MG/KG
05 - 12.5 MG/KG
06 - 12.5 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1002
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
91005-98
C91005C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/10/2000
SO
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 2.5 MG/KG
04 - 2.5 MG/KG
05 - 12.5 MG/KG
06 - 12.5 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1003
Methylene blue trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
91005-99
C91005C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/26/2000
SO
7220-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 5 MG/KG
04 - 5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1004
Methylene chloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05146-01
C50102C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/22/1986
MA
75-09-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ML/KG
02 - 2.5 ML/KG
03 - 5.0 ML/KG
04 - 10 ML/KG
V
T
T
T
M
M
M
M
DICHLOROMETHANE
Page 1005
Methyl ethyl ketone peroxide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05179-01
C55447B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/06/1987
HR
1338-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0% DMP VEHICLE
04 - 0% DMP VEHICLE
05 - 0.3%
06 - 0.3%
07 - 1%
08 - 1%
09 - 3%
10 - 3%
11 - 10%
12 - 10%
13 - 30%
14 - 30%
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1006
DIMETHYLPHTHALATE
Methyl ethyl ketone peroxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05179-02
C55447B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/20/1987
HR
1338-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0% DMP VEHICLE
04 - 0% DMP VEHICLE
05 - 0.3%
06 - 0.3%
07 - 1%
08 - 1%
09 - 3%
10 - 3%
11 - 10%
12 - 10%
13 - 30%
14 - 30%
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1007
DIMETHYLPHTHALATE
Methyl ethyl ketoxime
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88009-03
C88009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/21/1991
MB
96-29-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 312 PPM
03 - 625 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 5000 PPM
07 - CONTROL
08 - 312 PPM
09 - 625 PPM
10 - 1250 PPM
11 - 2500 PPM
12 - 5000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 1008
Methyl ethyl ketoxime (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88009-04
C88009
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/19/1991
MB
96-29-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 625 PPM
03 - 1250 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 10000 PPM
07 - CONTROL
08 - 625 PPM
09 - 1250 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 10000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
DEIONIZED WATER
Page 1009
Methyleugenol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05187-03
C60991
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/27/1988
SO
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - SHAM
04 - SHAM
05 - 10 MG/KG
06 - 10 MG/KG
07 - 30 MG/KG
08 - 30 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 300 MG/KG
12 - 300 MG/KG
13 - 1000 MG/KG
14 - 1000 MG/KG
V
V
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1010
DEIONIZED WATER
0.5 % AQUEOUS METHYLCELLULOSE
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05187-04
C60991
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/11/1988
SO
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - SHAM
04 - SHAM
05 - 10 MG/KG
06 - 10 MG/KG
07 - 30 MG/KG
08 - 30 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 300 MG/KG
12 - 300 MG/KG
13 - 1000 MG/KG
14 - 1000 MG/KG
V
V
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1011
DEIONIZED WATER
0.5 % AQUEOUS METHYLCELLULOSE
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05187-06
C60991B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/25/1993
BC
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37 MG/KG
04 - 37 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1012
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05187-08
C60991B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/25/1993
BC
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 37 MG/KG
02 - 37 MG/KG
03 - 75 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 150 MG/KG
T
T
T
T
T
T
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1013
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05187-09
C60991B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/07/1994
BC
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37 MG/KG
04 - 37 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1014
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05187-10
C60991B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/07/1994
BC
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 37 MG/KG
02 - 37 MG/KG
03 - 75 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 150 MG/KG
07 - 300 MG/KG
08 - 300 MG/KG
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1015
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
05187-11
C60991D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/06/2002
IL
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CTL 6HR
02 - CTL 24HR
03 - CTL 72HR
04 - 30MG/KG 6HR
05 - 30MG/KG 24HR
06 - 30MG/KG 72HR
07 - 10OMG/KG6HR
08 - 100MG/KG24HR
09 - 100MG/KG72HR
10 - 300MG/KG6HR
11 - 300MG/KG24HR
12 - 300MG/KG72HR
13 - 1000MGKG6HR
14 - 1000MGKG24HR
15 - 1000MGKG72HR
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1016
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
05187-12
C60991D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/10/2002
IL
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CTL 3D 24HR
02 - 30 MG/KG3D 24HR
03 - 100MG/KG3D 24HR
04 - 300MG/KG3D 24HR
05 - 1000MGKG3D 24HR
06 - CTL 7D 24HR
07 - 30MG/KG 7D 24HR
08 - 100MG/KG7D 24HR
09 - 300MG/KG7D 24HR
10 - 1000MGKG7D 24HR
11 - CTL 14D 24HR
12 - 30 MG/KG14D 24HR
13 - 100MG/KG14D 24HR
14 - 300MG/KG14D 24HR
15 - 1000MGKG14D 24HR
16 - CTL 14D 3MO
17 - 30 MG/KG14D 3MO
18 - 100MG/KG14D 3MO
19 - 300MG/KG14D 3MO
21 - CTL 14D 6MO
22 - 30 MG/KG14D 6MO
23 - 100MG/KG14D 6MO
24 - 300MG/KG14D 6MO
25 - 1000MGKG14D 6MO
U
T
T
T
T
U
T
T
T
T
U
T
T
T
T
U
T
T
T
U
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1017
Methyleugenol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
60991-01
C60991
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/25/2004
IL
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 0% DIET
02 - 0 MG/KG 10% DIET
03 - 0 MG/KG 20% DIET
04 - 0 MG/KG 30% DIET
05 - 1000 MG/KG
V
V
V
V
T
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1018
Methyleugenol (TGMX rat liver evaluation)
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
GAVAGE
20540-02
C20540C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
02/01/2006
BC
93-15-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - MEG 150 mg/kg
V
T
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1019
2-Methylimidazole
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
92012-01
C92012
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/13/1993
MB
693-98-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1200 PPM
03 - 3300 PPM
04 - 10000 PPM
05 - VEHICLE CONTROL
06 - 1200 PPM
07 - 3300 PPM
08 - 10000 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1020
2-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
92012-02
C92012
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/14/1993
MB
693-98-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1200 PPM
03 - 3300 PPM
04 - 10000 PPM
05 - VEHICLE CONTROL
06 - 1200 PPM
07 - 3300 PPM
08 - 10000 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1021
2-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
92012-03
C92012
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/20/1994
MB
693-98-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - 625 PPM
03 - 1250 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 10000 PPM
07 - UNTREAT CONTROL
08 - 625 PPM
09 - 1250 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 10000 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1022
2-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
92012-04
C92012
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/18/1994
MB
693-98-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - 625 PPM
03 - 1250 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 10000 PPM
07 - UNTREAT CONTROL
08 - 625 PPM
09 - 1250 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 10000 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1023
2-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92012-05
C92012B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/15/1998
SO
693-98-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 0PPM
03 - 300 PPM
04 - 1000 PPM
05 - 1000 PPM
06 - 2500 PPM
07 - 3000 PPM
08 - 5000 PPM
U
U
T
T
T
T
T
T
M
F
M
M
F
F
M
F
NTP-2000
Page 1024
2-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92012-06
C92012B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/29/1998
SO
693-98-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 0PPM
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1025
4-Methylimidazole
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
92013-01
C92013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/20/1993
MB
822-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 300 PPM
03 - 800 PPM
04 - 2500 PPM
05 - VEHICLE CONTROL
06 - 300 PPM
07 - 800 PPM
08 - 2500 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1026
4-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
92013-02
C92013
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/21/1993
MB
822-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 300 PPM
03 - 800 PPM
04 - 2500 PPM
05 - VEHICLE CONTROL
06 - 300 PPM
07 - 800 PPM
08 - 2500 PPM
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1027
4-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
92013-03
C92013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/03/1994
MB
822-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - 625 PPM
03 - 1250 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 10000 PPM
07 - UNTREAT CONTROL
08 - 625 PPM
09 - 1250 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 10000 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1028
4-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
92013-04
C92013
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/01/1994
MB
822-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - 625 PPM
03 - 1250 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 10000 PPM
07 - UNTREAT CONTROL
08 - 625 PPM
09 - 1250 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 10000 PPM
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1029
4-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92013-05
C92013B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/20/2000
SO
822-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 625 PPM
04 - 1250 PPM
05 - 1250 PPM
06 - 2500 PPM
07 - 2500 PPM
08 - 5000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1030
4-Methylimidazole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92013-06
C92013B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/03/2000
SO
822-36-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1031
Methyl isobutyl ketone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
97006-01
C97006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/25/2000
BN
108-10-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 450 PPM
04 - 450 PPM
05 - 900 PPM
06 - 900 PPM
07 - 1800 PPM
08 - 1800 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1032
Methyl isobutyl ketone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
97006-02
C97006
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/05/2000
BN
108-10-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 450 PPM
04 - 450 PPM
05 - 900 PPM
06 - 900 PPM
07 - 1800 PPM
08 - 1800 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1033
METHYL ISOCYANATE
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05149-01
C62146
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/10/1985
NE
624-83-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1 PPM
04 - 1 PPM
05 - 3 PPM
06 - 3 PPM
07 - 10 PPM
08 - 10 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1034
METHYL ISOCYANATE (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05149-02
C62146
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/29/1985
NE
624-83-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - UNTREATD CONTROL
04 - UNTREATD CONTROL
05 - 1 PPM
06 - 1 PPM
07 - 3 PPM
08 - 3 PPM
09 - 10 PPM
10 - 10 PPM
U
U
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIR
Page 1035
3-Methyl-6-methoxy-2-amino-benzothiazolium chloride
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05152-03
C61814
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/23/1987
MB
EMTDP-76
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/G
02 - 0 MG/G
03 - 0 MG/G SPECIAL
04 - 0.25 MG/G
05 - 0.25 MG/G
06 - 0.50 MG/G
07 - 0.50 MG/G
08 - 1.0 MG/G
09 - 1.0 MG/G
10 - 1.0 MG/GSPECIAL
11 - 2.0 MG/G
12 - 2.0 MG/G
13 - 2.0 MG/GSPECIAL
14 - 4.0 MG/G
15 - 4.0 MG/G
16 - 4.0 MG/GSPECIAL
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
M
F
M
F
M
F
M
M
F
M
M
F
M
NIH-07
Page 1036
3-Methyl-6-methoxy-2-amino-benzothiazolium chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05152-04
C61814
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/25/1987
MB
EMTDP-76
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/G
02 - 0 MG/G
03 - 0.25 MG/G
04 - 0.25 MG/G
05 - 0.50 MG/G
06 - 0.50 MG/G
07 - 1.0 MG/G
08 - 1.0 MG/G
09 - 2.0 MG/G
10 - 2.0 MG/G
11 - 4.0 MG/G
12 - 4.0 MG/G
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1037
N-Methylolacrylamide
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05024-01
C60333
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/19/1982
BC
924-42-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 6 MG/KG
04 - 6 MG/KG
05 - 12 MG/KG
06 - 12 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
DISTILLED WATER
Page 1038
N-Methylolacrylamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05024-02
C60333
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/26/1982
BC
924-42-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
DISTILLED WATER
Page 1039
Methylphenidate hydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05150-01
C56280B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/27/1986
MA
298-59-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1040
Methylphenidate hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05150-02
C56280B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/31/1986
MA
298-59-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 50 PPM
04 - 50 PPM
05 - 250 PPM
06 - 250 PPM
07 - 500 PPM
08 - 500 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1041
alpha-Methylstyrene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88006-01
C88006B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/28/2000
BN
98-83-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 150 PPM
06 - 150 PPM
07 - 300 PPM
08 - 300 PPM
09 - 600 PPM
10 - 600 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1042
alpha-Methylstyrene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
88006-02
C88006B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/28/2000
BN
98-83-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 150 PPM
06 - 150 PPM
07 - 300 PPM
08 - 300 PPM
09 - 600 PPM
10 - 600 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1043
alpha-Methylstyrene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88006-03
C88006B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/06/2001
BN
98-83-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 300 PPM
06 - 300 PPM
07 - 1000 PPM
08 - 1000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1044
alpha-Methylstyrene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88006-04
C88006B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/30/2001
BN
98-83-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 300 PPM
06 - 300 PPM
07 - 600 PPM
08 - 600 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1045
Methyl trans-styryl ketone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
95003-01
C95003B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/17/2001
MB
1896-62-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.025%
03 - 0.05%
04 - 0.1%
05 - 0.2%
06 - 0.4%
07 - VEHICLE CONTROL
08 - 0.025%
09 - 0.05%
10 - 0.1%
11 - 0.2%
12 - 0.4%
13 - CONTROL SPECIAL
14 - 0.025% SPECIAL
15 - 0.05% SPECIAL
16 - 0.1% SPECIAL
17 - 0.2% SPECIAL
18 - 0.4% SPECIAL
19 - CONTROL SPECIAL
20 - 0.025% SPECIAL
21 - 0.05% SPECIAL
22 - 0.1% SPECIAL
23 - 0.2% SPECIAL
24 - 0.4% SPECIAL
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
M
M
M
M
M
M
F
F
F
F
F
F
NTP-2000
Page 1046
Methyl trans-styryl ketone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
95003-02
C95003B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/20/2001
MB
1896-62-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.025%
03 - 0.05%
04 - 0.1%
05 - 0.2%
06 - 0.4%
07 - VEHICLE CONTROL
08 - 0.025%
09 - 0.05%
10 - 0.1%
11 - 0.2%
12 - 0.4%
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NTP-2000
Page 1047
Methyl trans-styryl ketone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
95003-03
C95003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/10/2001
MB
1896-62-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 22.0 MG/KG
03 - 44.0 MG/KG
04 - 87.5 MG/KG
05 - 175 MG/KG
06 - 350 MG/KG
07 - VEHICLE CONTROL
08 - 22.0 MG/KG
09 - 44.0 MG/KG
10 - 87.5 MG/KG
11 - 175 MG/KG
12 - 350 MG/KG
13 - CONTROL SPECIAL
14 - TK 22.0 MG/KG
15 - TK 44.0 MG/KG
16 - TK 87.5 MG/KG
17 - TK 175 MG/KG
18 - TK 350 MG/KG
19 - CONTROL SPECIAL
20 - TK 22.0 MG/KG
21 - TK 44.0 MG/KG
22 - TK 87.5 MG/KG
23 - TK 175 MG/KG
24 - TK 350 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 1048
Methyl trans-styryl ketone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
95003-04
C95003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/13/2001
MB
1896-62-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 87.5 MG/KG
03 - 175 MG/KG
04 - 350 MG/KG
05 - 700 MG/KG
06 - 1400 MG/KG
07 - VEHICLE CONTROL
08 - 87.5 MG/KG
09 - 175 MG/KG
10 - 350 MG/KG
11 - 700 MG/KG
12 - 1400 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 1049
Methyl trans-styryl ketone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
95003-05
C95003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/05/2004
SO
1896-62-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
07 - 90 MG/KG
08 - 90 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1050
Methyl trans-styryl ketone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
95003-06
C95003C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/26/2004
SO
1896-62-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
07 - 90 MG/KG
08 - 90 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1051
Methyl vinyl ketone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
92005-01
C92005
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/11/1998
NE
78-94-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 0PPM
03 - 0.5PPM
04 - 0.5PPM
05 - 1PPM
06 - 1PPM
07 - 2PPM
08 - 2PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1052
Methyl vinyl ketone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
92005-02
C92005
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/26/1998
NE
78-94-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 0PPM
03 - 0.5PPM
04 - 0.5PPM
05 - 1PPM
06 - 1PPM
07 - 2PPM
08 - 2PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1053
Microcystin-LA (TGMX)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
INTV INJ
20503-01
C20503
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/16/2010
BC
96180-79-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ug/Kg
02 - 10 ug/Kg
03 - 25 ug/Kg
04 - 50 ug/Kg
05 - 100 ug/Kg
V
T
T
T
T
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 1054
Microcystin-LR (TGMX)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
INTV INJ
20504-01
C20504
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
09/15/2008
BC
101043-37-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ug/kg
02 - 1 ug/kg
03 - 10 ug/kg
04 - 50 ug/kg
05 - 100 ug/kg
V
T
T
T
T
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 1055
Microcystin mixture (TGMX)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
INTV INJ
20501-01
C20501
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/18/2010
BC
MICROCYSTNMX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/Kg
02 - 1.49 mg/Kg
03 - 3.73 mg/Kg
04 - 7.46 mg/Kg
05 - 14.93 mg/Kg
V
T
T
T
T
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 1056
Milk thistle extract
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20008-01
C20008
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/17/2002
SO
84604-20-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3125 PPM
04 - 3125 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 1057
Milk thistle extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20008-02
C20008
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/19/2002
SO
84604-20-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3125 PPM
04 - 3125 PPM
05 - 6250 PPM
06 - 6250 PPM
07 - 12500 PPM
08 - 12500 PPM
09 - 25000 PPM
10 - 25000 PPM
11 - 50000 PPM
12 - 50000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP-2000
Page 1058
Milk thistle extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
20008-03
C20008
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/04/2003
SO
84604-20-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 12500 PPM
04 - 12500 PPM
05 - 25000 PPM
06 - 25000 PPM
07 - 50000 PPM
08 - 50000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1059
Milk thistle extract (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
20008-04
C20008
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/25/2003
SO
84604-20-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 12500 PPM
04 - 12500 PPM
05 - 25000 PPM
06 - 25000 PPM
07 - 50000 PPM
08 - 50000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1060
Molybdenum trioxide
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05158-03
C61369C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/15/1990
BN
1313-27-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 10 MG/M3
04 - 10 MG/M3
05 - 30 MG/M3
06 - 30 MG/M3
07 - 100 MG/M3
08 - 100 MG/M3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1061
Molybdenum trioxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05158-04
C61369C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/22/1990
BN
1313-27-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 10 MG/M3
04 - 10 MG/M3
05 - 30 MG/M3
06 - 30 MG/M3
07 - 100 MG/M3
08 - 100 MG/M3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1062
Monochloroacetic acid
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05705-01
C60231
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/25/1982
IR
79-11-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 50 MG/KG MALE
03 - 100MG/KG MALE
04 - CONTROL FEMALE
05 - 50 MG/KG FEMALE
06 - 100MG/KG FEMALE
V
T
T
V
T
T
M
M
M
F
F
F
DEIONIZED WATER
Page 1063
Monochloroacetic acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05705-02
C60231
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/31/1982
IR
79-11-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 15 MG/KG MALE
03 - 30 MG/KG MALE
04 - CONTROL FEMALE
05 - 15 MG/KG FEMALE
06 - 30 MG/KG FEMALE
V
T
T
V
T
T
M
M
M
F
F
F
DEIONIZED WATER
Page 1064
Monocrotaline
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20414-01
C20414
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/13/2004
IL
315-22-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6 HR
02 - 10 MG/KG 6 HR
03 - 50 MG/KG 6 HR
04 - 300 MG/KG 6 HR
05 - 0 MG/KG 24 HR
06 - 10 MG/KG 24 HR
07 - 50 MG/KG 24 HR
08 - 300 MG/KG 24 HR
09 - 0 MG/KG 48 HR
10 - 10 MG/KG 48 HR
11 - 50 MG/KG 48 HR
12 - 300 MG/KG 48 HR
V
T
T
T
V
V
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 1065
Mouse ageing study
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC-LIFETIME
NOT APPL
05126-02
C62419
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/24/1985
MA
MOUSEAGE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - LIFETIME
02 - LIFETIME
U
U
M
F
NIH-07
Page 1066
beta-Myrcene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99023-01
C99023
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/29/2001
BC
123-35-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0.25 G/KG
03 - 0.5 G/KG
04 - 1.0 G/KG
05 - 2.0 G/KG
06 - 4.0 G/KG
07 - 0 G/KG
08 - 0.25 G/KG
09 - 0.5 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 4.0 G/KG
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1067
beta-Myrcene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99023-02
C99023
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/31/2001
BC
123-35-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0.25 G/KG
03 - 0.5 G/KG
04 - 1.0 G/KG
05 - 2.0 G/KG
06 - 4.0 G/KG
07 - 0 G/KG
08 - 0.25 G/KG
09 - 0.5 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 4.0 G/KG
U
T
T
T
T
T
U
T
T
T
T
T
F
F
F
F
F
F
M
M
M
M
M
M
CORN OIL
Page 1068
beta-Myrcene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99023-03
C99023
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/25/2002
BC
123-35-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.25 G/KG
04 - 0.25 G/KG
05 - 0.5 G/KG
06 - 0.5 G/KG
07 - 1.0 G/KG
08 - 1.0 G/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1069
beta-Myrcene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99023-04
C99023
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/10/2002
BC
123-35-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.25 G/KG
04 - 0.25 G/KG
05 - 0.5 G/KG
06 - 0.5 G/KG
07 - 1.0 G/KG
08 - 1.0 G/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1070
beta-Myrcene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99023-99
C99023
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/29/2001
BC
123-35-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0.25 G/KG
03 - 0.5 G/KG
04 - 1.0 G/KG
05 - 2.0 G/KG
06 - 4.0 G/KG
07 - 0 G/KG
08 - 0.25 G/KG
09 - 0.5 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 4.0 G/KG
U
T
T
T
T
T
U
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1071
Myristicin
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99009-01
C99009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/20/2009
BC
607-91-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 10 mg/kg
04 - 10 mg/kg
05 - 30 mg/kg
06 - 30 mg/kg
07 - 100 mg/kg
08 - 100 mg/kg
09 - 300 mg/kg
10 - 300 mg/kg
11 - 600 mg/kg
12 - 600 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1072
Myristicin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99009-02
C99009
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/22/2009
BC
607-91-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 10 mg/kg
04 - 10 mg/kg
05 - 30 mg/kg
06 - 30 mg/kg
07 - 100 mg/kg
08 - 100 mg/kg
09 - 300 mg/kg
10 - 300 mg/kg
11 - 600 mg/kg
12 - 600 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1073
Myristicin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
99009-99
C99009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/20/2009
BC
607-91-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 10 mg/kg
04 - 10 mg/kg
05 - 30 mg/kg
06 - 30 mg/kg
07 - 100 mg/kg
08 - 100 mg/kg
09 - 300 mg/kg
10 - 300 mg/kg
11 - 600 mg/kg
12 - 600 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1074
N,N-DIMETHYL-P-TOLUIDINE
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
06191-01
C06191
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/05/2001
BC
99-87-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5000 PPM
04 - 5000 PPM
05 - 10000 PPM
06 - 10000 PPM
07 - 20000 PPM
08 - 20000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1075
N,N-DIMETHYL-P-TOLUIDINE (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
06191-02
C06191
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/05/2001
BC
99-87-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5000 PPM
04 - 5000 PPM
05 - 10000 PPM
06 - 10000 PPM
07 - 20000 PPM
08 - 20000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1076
Nanoscale material (Fullerene-C60 1 micron)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP NAS
20701-01
C20701
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/05/2007
BN
99685-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 2 mg/m3
04 - 2 mg/m3
05 - 15 mg/m3
06 - 15 mg/m3
07 - 30 mg/m3
08 - 30 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1077
Nanoscale material (Fullerene-C60 1 micron) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP NAS
20701-02
C20701
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/05/2007
BN
99685-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 2 mg/m3
04 - 2 mg/m3
05 - 15 mg/m3
06 - 15 mg/m3
07 - 30 mg/m3
08 - 30 mg/m3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1078
Nanoscale material (Fullerene-C60 50 nanometers)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP NAS
20407-01
C20407
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/05/2007
BN
99685-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 0.5 mg/m3
04 - 0.5 mg/m3
05 - 2.0 mg/m3
06 - 2.0 mg/m3
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 1079
Nanoscale material (Fullerene-C60 50 nanometers) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP NAS
20407-02
C20407
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/05/2007
BN
99685-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/m3
02 - 0 mg/m3
03 - 0.5 mg/m3
04 - 0.5 mg/m3
05 - 2.0 mg/m3
06 - 2.0 mg/m3
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 1080
Nanoscale Silver
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20726-01
C20726
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprague Dawley (NCTR)
09/21/2011
NR
7440-22-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle Male 0
02 - Vehicle Fem 0
03 - AgNP 10 Male 9
04 - AgNP 10 Fem 9
05 - AgNP 10 Male 18
06 - AgNP 10 Fem 18
07 - AgNP 10 Male 36
08 - AgNP 10 Fem 36
09 - AgNP 75 Male 9
10 - AgNP 75 Fem 9
11 - AgNP 75 Male 18
12 - AgNP 75 Fem 18
13 - AgNP 75 Male 36
14 - AgNP 75 Fem 36
15 - AgNP 107 Male 9
16 - AgNP 107 Fem 9
17 - AgNP 107 Male 18
18 - AgNP 107 Fem 18
19 - AgNP 107 Male 36
20 - AgNP 107 Fem 36
21 - AgOAc Male 100
22 - AgOAc Fem 100
23 - AgOAc Male 200
24 - AgOAc Fem 200
25 - AgOAc Male 400
26 - AgOAc Fem 400
27 - H2O/MC Male Ctrl
28 - H2O/MC Fem Ctrl
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
U
U
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
Sodium citrate 2mM/0.5% CMC
Page 1081
H2O/0.1% MC
Naphthalene
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05110-01
C52904B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/31/1982
NS
91-20-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 10 PPM
04 - 10 PPM
05 - 30 PPM
06 - 30 PPM
07 - 30 PPM
08 - 30 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1082
Naphthalene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05110-02
C52904C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/28/1996
BN
91-20-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 10 PPM
04 - 10 PPM
05 - 30 PPM
06 - 30 PPM
07 - 60 PPM
08 - 60 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1083
NCT/DERT standardization experiment (APAP & AMAP)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20404-01
C20404
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, C57BL/6J
09/22/2004
BC
NCTSTANDARD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 300 APAP MG/KG
03 - 300 AMAP MG/KG
V
T
T
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1084
NCTR Universal Download
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05050-11
C12345C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
(NOT DEFINED)
NR
C12345C
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1085
NCTR Universal Download (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05050-12
C12345C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
(NOT DEFINED)
NR
C12345C
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1086
Nickel (II) oxide
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05123-05
C00862
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/04/1988
LI
1313-99-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/M3
02 - 0 MG/M3
03 - 0 MG/M3 LUNGTX
04 - 0 MG/M3 LUNGTX
05 - 0.62MGM3
06 - 0.62MGM3
07 - 0.62MGM3 LUNGTX
08 - 0.62MGM3 LUNGTX
09 - 1.25MGM3
10 - 1.25MGM3
11 - 1.25MGM3 LUNGTX
12 - 1.25MGM3 LUNGTX
13 - 2.5MG/M3
14 - 2.5MG/M3
15 - 2.5MG/M3 LUNGTX
16 - 2.5MG/M3 LUNGTX
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1087
(UNSPECIFIED)
Nickel (II) oxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP NAS
05123-06
C00862
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/25/1988
LI
1313-99-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/M3
02 - 0 MG/M3
03 - O MG/M3 LUNGTX
04 - 0 MG/M3 LUNGTX
05 - 1.25MGM3
06 - 1.25MGM3
07 - 1.25MGM3 LUNGTX
08 - 1.25MGM3 LUNGTX
09 - 2.5MG/M3
10 - 2.5MG/M3
11 - 2.5MG/M3 LUNGTX
12 - 2.5MG/M3 LUNGTX
13 - 5.0MG/M3
14 - 5.0MG/M3
15 - 5.0MG/M3 LUNGTX
16 - 5.0MG/M3 LUNGTX
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1088
(UNSPECIFIED)
Nickel sulfate hexahydrate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05122-05
C60344
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/20/1988
LI
10101-97-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0MG/M3
02 - 0.0MG/M3
03 - 0.0MG/M3LUNG TOX
04 - 0.0MG/M3LUNG TOX
05 - 0.12 MG/M3
06 - 0.12 MG/M3
07 - 0.12MGM3LUNG TOX
08 - 0.12MGM3LUNG TOX
09 - 0.25 MG/M3
10 - 0.25 MG/M3
11 - 0.25MGM3LUNG TOX
12 - 0.25MGM3LUNG TOX
13 - 0.5MG/M3
14 - 0.5MG/M3
15 - 0.5MG/M3LUNG TOX
16 - 0.5MG/M3LUNG TOX
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1089
(UNSPECIFIED)
Nickel sulfate hexahydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP NAS
05122-06
C60344
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/30/1988
LI
10101-97-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/M3
02 - 0.0 MG/M3
03 - 0.0MG/M3LUNG TOX
04 - 0.0MG/M3LUNG TOX
05 - 0.25 MG/M3
06 - 0.25 MG/M3
07 - .25MG/M3LUNG TOX
08 - .25MG/M3LUNG TOX
09 - 0.5 MG/M3
10 - 0.5 MG/M3
11 - 0.5MG/M3LUNG TOX
12 - 0.5MG/M3LUNG TOX
13 - 1.0 MG/M3
14 - 1.0 MG/M3
15 - 1.0MG/M3LUNG TOX
16 - 1.0MG/M3LUNG TOX
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1090
(UNSPECIFIED)
Nickel subsulfide
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05107-05
C61654
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/31/1988
LI
12035-72-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0MG/M3
02 - 0.0MG/M3
03 - 0.0MG/M3LUNG TOX
04 - 0.0MG/M3LUNG TOX
05 - 0.15 MG/M3
06 - 0.15 MG/M3
07 - 0.15 LUNG TOX
08 - 0.15 LUNG TOX
09 - 1.0 MG/M3
10 - 1.0 MG/M3
11 - 1.0 LUNG TOX
12 - 1.0 LUNG TOX
U
U
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1091
(UNSPECIFIED)
Nickel subsulfide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05107-06
C61654
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/29/1988
LI
12035-72-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0MG/M3
02 - 0.0MG/M3
03 - 0.0MG/M3LUNG TOX
04 - 0.0MG/M3LUNG TOX
05 - 0.6MG/M3
06 - 0.6MG/M3
07 - 0.6MG/M3LUNG TOX
08 - 0.6MG/M3LUNG TOX
09 - 1.2MG/M3
10 - 1.2MG/M3
11 - 1.2MG/M3LUNG TOX
12 - 1.2MG/M3LUNG TOX
U
U
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1092
(UNSPECIFIED)
p-Nitroaniline
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05093-01
C60786B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/25/1984
SO
100-01-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE 9 SSAC
03 - VEHICLE 15 SSAC
04 - VEHICLE CONTROL
05 - VEHICLE 9 SSAC
06 - VEHICLE 15 SSAC
07 - 100MG/KG
08 - 100MG/KG 9 SSAC
09 - 100MG/KG 15 SSAC
10 - 100MG/KG
11 - 100MG/KG 9 SSAC
12 - 100MG/KG 15 SSAC
13 - 30 MG/KG
14 - 30 MG/KG 9 SSAC
15 - 30 MG/KG 15 SSAC
16 - 30 MG/KG
17 - 30 MG/KG 9 SSAC
18 - 30 MG/KG 15 SSAC
19 - 3 MG/KG
20 - 3 MG/KG 9 SSAC
21 - 3 MG/KG 15 SSAC
22 - 3 MG/KG
23 - 3 MG/KG 9 SSAC
24 - 3 MG/KG 15 SSAC
V
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
F
F
F
M
M
M
F
F
F
M
M
M
F
F
F
M
M
M
F
F
F
CORN OIL
Page 1093
o-Nitroanisole
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05092-01
C60388B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/11/1984
SO
91-23-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0% 15 SSAC
03 - 0.0%
04 - 0.0% 15 SSAC
05 - 0.200%
06 - 0.200% 15 SSAC
07 - 0.200%
08 - 0.200% 15 SSAC
09 - 0.0666%
10 - 0.0666% 15 SSAC
11 - 0.0666%
12 - 0.0666% 15 SSAC
13 - 0.0222%
14 - 0.0222% 15 SSAC
15 - 0.0222%
16 - 0.0222% 15 SSAC
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
NIH-07
Page 1094
o-Nitroanisole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05092-02
C60388B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/23/1984
SO
91-23-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0% 15 SSAC
03 - 0.0%
04 - 0.0% 15 SSAC
05 - 0.600%
06 - 0.600% 15 SSAC
07 - 0.600%
08 - 0.600% 15 SSAC
09 - 0.200%
10 - 0.200% 15 SSAC
11 - 0.200%
12 - 0.200% 15 SSAC
13 - 0.0666%
14 - 0.0666% 15 SSAC
15 - 0.0666%
16 - 0.0666% 15 SSAC
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
NIH-07
Page 1095
o-Nitroanisole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05092-03
C60388B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/18/1984
SO
91-23-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0% 3 SSAC
03 - 0.0% 6 SSAC
04 - 0.0% 9 SSAC
05 - 0.0% 15 SSAC
06 - 0.0%
07 - 0.0% 3 SSAC
08 - 0.0% 6 SSAC
09 - 0.0% 9 SSAC
10 - 0.0% 15 SSAC
11 - 1.80%
12 - 1.80% 3 SSAC
13 - 1.80% 6 SSAC
14 - 1.80% 9 SSAC
15 - 1.80% 15 SSAC
16 - 1.80%
17 - 1.80% 3 SSAC
18 - 1.80% 6 SSAC
19 - 1.80% 9 SSAC
20 - 1.80% 15 SSAC
21 - 0.600%
22 - 0.600% 3 SSAC
23 - 0.600% 6 SSAC
24 - 0.600% 9 SSAC
25 - 0.600% 15 SSAC
26 - 0.600%
27 - 0.600% 3 SSAC
28 - 0.600% 6 SSAC
29 - 0.600% 9 SSAC
30 - 0.600% 15 SSAC
U
U
U
U
U
U
U
U
U
U
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
F
F
F
F
F
M
M
M
M
M
F
F
F
F
F
M
M
M
M
M
F
F
F
F
F
NIH-07
Page 1096
m-Nitrobenzoic acid
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05148-01
C61767
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/17/1986
MB
121-92-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0% MALE
02 - 0.063% MALE
03 - 0.125% MALE
04 - 0.25% MALE
05 - 0.5% MALE
06 - 1.0% MALE
07 - 0% FEMALE
08 - 0.063% FEMALE
09 - 0.125% FEMALE
10 - 0.25% FEMALE
11 - 0.5% FEMALE
12 - 1.0% FEMALE
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1097
m-Nitrobenzoic acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05148-02
C61767
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/20/1986
MB
121-92-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0% MALE
02 - 0.125% MALE
03 - 0.25% MALE
04 - 0.5% MALE
05 - 1.0% MALE
06 - 2.0% MALE
07 - 0% FEMALE
08 - 0.125% FEMALE
09 - 0.25% FEMALE
10 - 0.5% FEMALE
11 - 1.0% FEMALE
12 - 2.0% FEMALE
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1098
p-Nitrobenzoic acid
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05155-01
C61778
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/22/1986
MB
62-23-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.063%
04 - 0.063%
05 - 0.125%
06 - 0.125%
07 - 0.25%
08 - 0.25%
09 - 0.5%
10 - 0.5%
11 - 1.0%
12 - 1.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1099
p-Nitrobenzoic acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05155-02
C61778
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/20/1986
MB
62-23-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.125%
04 - 0.125%
05 - 0.25%
06 - 0.25%
07 - 0.5%
08 - 0.5%
09 - 1.0%
10 - 1.0%
11 - 2.0%
12 - 2.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1100
p-Nitrobenzoic acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05155-03
C61778B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/11/1988
SO
62-23-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.125%
04 - 0.125%
05 - 0.25%
06 - 0.25%
07 - 0.5%
08 - 0.5%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1101
p-Nitrobenzoic acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05155-04
C61778B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/25/1988
SO
62-23-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.125%
04 - 0.125%
05 - 0.25%
06 - 0.25%
07 - 0.5%
08 - 0.5%
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1102
Nitrofurantoin
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05051-01
C55196
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/26/1981
SO
67-20-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.25%
04 - 0.13%
05 - 0.13%
06 - 0.06%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1103
Nitrofurantoin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05051-02
C55196
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/19/1981
SO
67-20-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.25%
04 - 0.25%
05 - 0.13%
06 - 0.13%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1104
Nitromethane
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05200-03
C61927
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/05/1988
BN
75-52-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 94 PPM
04 - 94 PPM
05 - 188 PPM
06 - 188 PPM
07 - 375 PPM
08 - 375 PPM
09 - 750 PPM
10 - 750 PPM
11 - 1500 PPM
12 - 1500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1105
Nitromethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05200-04
C61927
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/06/1988
BN
75-52-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 94 PPM
04 - 94 PPM
05 - 188 PPM
06 - 188 PPM
07 - 375 PPM
08 - 375 PPM
09 - 750 PPM
10 - 750 PPM
11 - 1500 PPM
12 - 1500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1106
Nitromethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05200-05
C61927
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/07/1989
BN
75-52-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 94 PPM
04 - 94 PPM
05 - 188 PPM
06 - 188 PPM
07 - 375 PPM
08 - 375 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1107
Nitromethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05200-06
C61927
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/31/1989
BN
75-52-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 188 PPM
04 - 188 PPM
05 - 375 PPM
06 - 375 PPM
07 - 750 PPM
08 - 750 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1108
p-Nitrophenol
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05098-01
C55992B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS WEBST
11/07/1984
HR
100-02-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG VM
02 - 0 MG/KG VF
03 - 40 MG/KG LM
04 - 40 MG/KG LF
05 - 80 MG/KG MM
06 - 80 MG/KG MF
07 - 160 MG/KG HM
08 - 160 MG/KG HF
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1109
1-Nitropyrene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP NAS
61938-01
C61938
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/08/1991
BN
5522-43-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.5 MG/M3
04 - 0.5 MG/M3
05 - 2.0 MG/M3
06 - 2.0 MG/M3
07 - 8.0 MG/M3
08 - 8.0 MG/M3
09 - 20.0 MG/M3
10 - 20.0 MG/M3
11 - 50.0 MG/M3
12 - 50.0 MG/M3
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1110
N-Nitrosodimethylamine (TGMX rat liver evaluation)
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
WATER
20540-03
C20540D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
02/01/2006
BC
62-75-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - DMNA 5ppm
V
T
M
M
DEIONIZED WATER
Page 1111
N-Nitrosomorpholine
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20413-01
C20413
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/05/2004
IL
59-89-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6 HR
02 - 10 MG/KG 6 HR
03 - 50 MG/KG 6 HR
04 - 300 MG/KG 6 HR
05 - 0 MG/KG 24 HR
06 - 10 MG/KG 24 HR
07 - 50 MG/KG 24 HR
08 - 300 MG/KG 24 HR
09 - 0 MG/KG 48 HR
10 - 10 MG/KG 48 HR
11 - 50 MG/KG 48 HR
12 - 300 MG/KG 48 HR
V
T
T
T
V
V
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 1112
m-Nitrotoluene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05204-03
C62351
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/18/1989
HR
99-08-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 675 PPM
04 - 675 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1113
m-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05204-04
C62351
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/16/1989
HR
99-08-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 675 PPM
04 - 675 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1114
o-Nitrotoluene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05203-03
C62340
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/12/1989
HR
88-72-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1115
o-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05203-04
C62340
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/15/1989
HR
88-72-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1116
o-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
05203-07
C62340C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/06/1992
BC
88-72-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONT-NOR ISAC
02 - CONT-ALT ISAC
03 - NTOL-NOR ISAC
04 - NTOL-ALT ISAC
05 - TOLU-NOR ISAC
06 - CONT-ALTTERM-REV
07 - NTOL-NORTERM-REV
08 - NTOL-ALTTERM-REV
09 - TOLU-NORTERM-REV
10 - CONT-NORTERM-FUL
11 - NTOL-NORTERM-FUL
12 - TOLU-NORTERM-FUL
U
U
T
T
T
U
T
T
T
U
T
T
M
M
M
M
M
M
M
M
M
M
M
M
NIH-07
Page 1117
o-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05203-08
C62340D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/08/1996
SO
88-72-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2000 PPM
08 - 2000 PPM
09 - 2000 PPM(STOP)
10 - 5000 PPM(STOP)
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
M
NTP-2000
Page 1118
o-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05203-09
C62340D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/20/1996
SO
88-72-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1250 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1119
p-Nitrotoluene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05205-03
C60537B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/07/1988
HR
99-99-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 675 PPM
04 - 675 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1120
p-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05205-04
C60537B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/06/1988
HR
99-99-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 675 PPM
04 - 675 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1121
p-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05205-07
C62537D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/28/1995
SO
99-99-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1250 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1122
p-Nitrotoluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05205-08
C62537D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/14/1995
SO
99-99-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1250 PPM
04 - 1250 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1123
NTP-2000 diet
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
95001-01
C95001
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/13/1994
NE
DIET2000
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 7M
02 - 7F
03 - 2000M
04 - 2000F
U
U
T
T
M
F
M
F
NIH-07
Page 1124
(UNSPECIFIED)
NTP 90 diet study
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92003-01
C92003
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/12/1990
NE
DIET90
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 7AM
02 - 7AF
03 - 9AM
04 - 9AF
U
U
T
T
M
F
M
F
NIH-07
Page 1125
(UNSPECIFIED)
NTP 90 diet study (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92003-02
C92003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/12/1990
NE
DIET90
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 7M
02 - 9M
03 - 7F
04 - 9F
U
T
U
T
M
M
F
F
NIH-07
(UNSPECIFIED)
NIH-07
(UNSPECIFIED)
Page 1126
NTP 91/92 diet study
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
92004-01
C92004
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/30/1992
NE
DIET9192
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 07F
02 - 07M
03 - 91F
04 - 91M
05 - 92F
06 - 92M
U
U
T
T
T
T
F
M
F
M
F
M
NIH-07
Page 1127
(UNSPECIFIED)
NTP-88 diet study (EGMBE)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05197-04
C62077B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/14/1988
MA
DIET88+EGMBE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 4500 PPM
04 - 4500 PPM
05 - 6000 PPM
06 - 6000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
DEIONIZED WATER
Page 1128
NTP-88 diet study (EGMBE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05197-08
C62077B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/21/1988
MA
DIET88+EGMBE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 4500 PPM
04 - 4500 PPM
05 - 6000 PPM
06 - 6000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
DEIONIZED WATER
Page 1129
NTP-88 diet study (EGMEE)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05198-04
C54853C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/03/1988
MA
DIET88+EGMEE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5000 PPM
04 - 5000 PPM
05 - 10000 PPM
06 - 10000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
DEIONIZED WATER
Page 1130
NTP-88 diet study (EGMEE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05198-08
C54853C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/26/1988
MA
DIET88+EGMEE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 20000 PPM
04 - 20000 PPM
05 - 40000 PPM
06 - 40000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
DEIONIZED WATER
Page 1131
NTP-88 diet study (EGMME)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05199-04
C62135B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/19/1988
MA
DIET88+EGMME
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3000 PPM
04 - 3000 PPM
05 - 4500 PPM
06 - 4500 PPM
U
U
T
T
T
T
M
F
M
F
M
F
DEIONIZED WATER
Page 1132
NTP-88 diet study (EGMME) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05199-08
C62135B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/12/1988
MA
DIET88+EGMME
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 6000 PPM
04 - 6000 PPM
05 - 8000 PPM
06 - 8000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
DEIONIZED WATER
Page 1133
NTP-88 diet study (m-Nitrotoluene)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05204-05
C62351B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/11/1989
HR
DIET88+MNITR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NTP-88
Page 1134
NTP-88 diet study (m-Nitrotoluene) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05204-06
C62351B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/10/1989
HR
DIET88+MNITR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5000 PPM
04 - 5000 PPM
05 - 10000 PPM
06 - 10000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NTP-88
Page 1135
NTP-88 diet study (o-Nitrotoluene)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05203-05
C62340B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/01/1989
HR
DIET88+ONITR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NTP-88
Page 1136
NTP-88 diet study (o-Nitrotoluene) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05203-06
C62340B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/28/1989
HR
DIET88+ONITR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5000 PPM
04 - 5000 PPM
05 - 10000 PPM
06 - 10000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NTP-88
Page 1137
NTP-88 diet study (p-Nitrotoluene)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05205-05
C60537C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/31/1988
HR
DIET88+PNITR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NTP-88
Page 1138
NTP-88 diet study (p-Nitrotoluene) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05205-06
C60537C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/30/1988
HR
DIET88+PNITR
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5000 PPM
04 - 5000 PPM
05 - 10000 PPM
06 - 10000 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NTP-88
Page 1139
Nelfinavir mesylate
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
20604-99
IM20604
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/22/2007
VC
159989-65-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 336 mg/kg
03 - 672 mg/kg
04 - 1008 mg/kg
05 - CPS 50 mg/kg
V
T
T
T
P
F
F
F
F
F
50% Aqueous HPCD
Page 1140
Ochratoxin A
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05036-01
C56586
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/20/1982
BC
303-47-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 21 UG/KG
03 - 70 UG/KG
04 - 210 UG/ KG
06 - 0 UG/KG
07 - 21 UG/KG
08 - 70 UG/KG
09 - 210 UG/ KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
CORN OIL
Page 1141
Oleic acid diethanolamine condensate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
91014-01
C91014
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/25/1992
BC
93-83-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
11 - 400 MG/KG
12 - 400 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1142
Oleic acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
91014-02
C91014
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/23/1992
BC
93-83-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 100 MG/KG
07 - 200 MG/KG
08 - 200 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 800 MG/KG
12 - 800 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1143
Oleic acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
91014-03
C91014
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/19/1993
BC
93-83-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 50 MG/KG
04 - 50 MG/KG
05 - 100MG/KG
06 - 100MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1144
Oleic acid diethanolamine condensate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
91014-04
C91014
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/10/1993
BC
93-83-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 15 MG/KG
04 - 15 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1145
Oxazepam
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05212-01
C62453
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/18/1988
BC
604-75-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10,000 PPM
12 - 10,000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1146
Oxazepam (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05212-02
C62453
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS WEBST
06/08/1988
BC
604-75-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10,000 PPM
12 - 10,000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1147
Oxazepam (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05212-03
C62453
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/22/1989
BC
604-75-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 125 PPM
04 - 125 PPM
05 - 2500 PPM
06 - 2500 PPM
07 - 5000 PPM
08 - 5000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1148
Oxazepam (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05212-04
C62453
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SWISS WEBST
07/13/1989
BC
604-75-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2500 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 5000 PPM
V
V
T
T
T
T
F
M
F
M
F
M
NIH-07
Page 1149
Oxazepam (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05212-05
C62453B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/23/1991
BC
604-75-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 625 PPM
04 - 625 PPM
05 - 1250 PPM
06 - 1250 PPM
07 - 2500 PPM
08 - 2500 PPM
09 - 5000 PPM
10 - 5000 PPM
11 - 10,000 PPM STOP
12 - 10,000 PPM STOP
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1150
Oxymetholone
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88032-03
C88032B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/11/1992
BC
434-07-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 80 MG/KG
04 - 80 MG/KG
05 - 160 MG/KG
06 - 160 MG/KG
07 - 315 MG/KG
08 - 315 MG/KG
09 - 625 MG/KG
10 - 625 MG/KG
11 - 1250 MG/KG
12 - 1250 MG/KG
13 - 0 MG/KG HCC
14 - 0 MG/KG HCC
15 - 80 MG/KGHCC
16 - 80 MG/KGHCC
17 - 160MG/KGHCC
18 - 160MG/KGHCC
19 - 315MG/KGHCC
20 - 315MG/KGHCC
21 - 625MG/KGHCC
22 - 625MG/KGHCC
23 - 1250 MG/KGHCC
24 - 1250 MG/KGHCC
V
V
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1151
Oxymetholone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88032-04
C88032B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/13/1992
BC
434-07-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 160 MG/KG
04 - 160 MG/KG
05 - 320 MG/KG
06 - 320 MG/KG
07 - 630 MG/KG
08 - 630 MG/KG
09 - 1250 MG/KG
10 - 1250 MG/KG
11 - 2500 MG/KG
12 - 2500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1152
Oxymetholone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88032-05
C88032B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/21/1993
BC
434-07-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
07 - 150 MG/KG
08 - 100 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1153
Ozone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88034-03
C88034
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/25/1990
BN
10028-15-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.12 PPM
04 - 0.12 PPM
05 - 0.5 PPM
06 - 0.5 PPM
07 - 1.0 PPM
08 - 1.0 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1154
Ozone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88034-04
C88034
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/09/1989
BN
10028-15-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.12 PPM
04 - 0.12 PPM
05 - 0.5 PPM
06 - 0.5 PPM
07 - 1.0 PPM
08 - 1.0 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1155
Ozone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC 30-MONTH
RESP BDY
88034-05
C88034B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/26/1989
BN
10028-15-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.5 PPM
04 - 0.5 PPM
05 - 1.0 PPM
06 - 1.0 PPM
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 1156
Ozone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC 30-MONTH
RESP BDY
88034-06
C88034B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/16/1989
BN
10028-15-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.5 PPM
04 - 0.5 PPM
05 - 1.0 PPM
06 - 1.0 PPM
V
V
T
T
T
T
M
F
M
F
M
F
AIR
Page 1157
Ozone (Airways Disease Project)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
RESP BDY
20706-01
C20706
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, DBA/2J
10/01/2007
BN
10028-15-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - control
02 - 0.3 ppm Ozone
V
T
M
M
AIR
Page 1158
Ozone/NNK
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
88034-07
C88034C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/27/1989
BN
OZONNNKCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - TRIOCT./AIR
02 - .1MG/KG NNK/AIR
03 - 1 MG/KG NNK/AIR
04 - TRIOCT./OZONE
05 - .1M/KNNK/OZONE
06 - 1M/K NNK/OZONE
V
T
T
T
T
T
M
M
M
M
M
M
AIR, TRIOCTANOIN
Page 1159
PCN 66/67 comparison study
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20306-01
C20306
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/09/2003
BC
PCNCOMPARISN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 1 NG/KG
03 - 3 NG/KG
04 - 10 NG/KG
05 - 100 NG/KG
06 - 300 NG/KG
07 - 500 NG/KG 66
08 - 1500 NG/KG 66
09 - 5000 NG/KG 66
10 - 50,000 NG/KG 66
11 - 500,000 NG/KG 66
12 - 500 NG/KG 67
13 - 1500 NG/KG 67
14 - 5000 NG/KG 67
15 - 50,000 NG/KG 67
16 - 500,000 NG/KG 67
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1160
PCN 66/67 comparison study (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20306-02
C20306
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/06/2003
BC
PCNCOMPARISN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 1000 NG/KG 66
03 - 10,000 NG/KG 66
04 - 50,000 NG/KG 66
05 - 100,000 NG/KG 66
06 - 200,000 NG/KG 66
07 - 1000 NG/KG 67
08 - 10,000 NG/KG 67
09 - 50,000 NG/KG 67
10 - 100,000 NG/KG 67
11 - 200,000 NG/KG 67
V
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1161
PCN 66/67 comparison study (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20306-03
C20306
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/13/2003
BC
PCNCOMPARISN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 1000 NG/KG 66
03 - 10,000 NG/KG 66
04 - 50,000 NG/KG 66
05 - 100,000 NG/KG 66
06 - 200,000 NG/KG 66
07 - 1000 NG/KG 67
08 - 10,000 NG/KG 67
09 - 50,000 NG/KG 67
10 - 100,000 NG/KG 67
11 - 200,000 NG/KG 67
12 - 1 NG/KG
13 - 10 NG/KG
14 - 50 NG/KG
15 - 100 NG/KG
16 - 200 NG/KG
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1162
PCN 66/67 comparison study (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20306-99
C20306
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
10/06/2003
BC
PCNCOMPARISN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 1000 NG/KG 66
03 - 200,000 NG/KG 66
04 - 1000 NG/KG 67
05 - 200,000 NG/KG 67
06 - 1 NG/KG
07 - 10 NG/KG
08 - 50 NG/KG
09 - 100 NG/KG
10 - 200 NG/KG
V
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1163
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20209-01
C20209
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/19/2004
SO
32534-81-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.01 MG/KG
04 - 0.01 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1164
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20209-02
C20209
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/21/2004
SO
32534-81-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.01 MG/KG
04 - 0.01 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1165
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20209-03
C20209
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
08/26/2008
SO
32534-81-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 15 MG/KG
06 - 15 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1166
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20209-04
C20209
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/25/2008
SO
32534-81-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1167
Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20209-99
C20209
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/19/2004
SO
32534-81-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.01 MG/KG
04 - 0.01 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1168
Pentachloroanisole
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05037-03
C56520
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/26/1983
SO
1825-21-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE 9 SSAC
03 - VEHICLE 15 SSAC
04 - VEHICLE CONTROL
05 - VEHICLE 9 SSAC
06 - VEHICLE 15 SSAC
07 - 40 MG/KG
08 - 40 MG/KG 9 SSAC
09 - 40 MG/KG 15 SSAC
10 - 40 MG/KG
11 - 40 MG/KG 9 SSAC
12 - 40 MG/KG 15 SSAC
13 - 20 MG/KG
14 - 20 MG/KG 9 SSAC
15 - 20 MG/KG 15 SSAC
16 - 20 MG/KG
17 - 20 MG/KG 9 SSAC
18 - 20 MG/KG 15 SSAC
19 - 10 MG/KG
20 - 10 MG/KG 9 SSAC
21 - 10 MG/KG 15 SSAC
V
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
F
F
F
M
M
M
F
F
F
M
M
M
F
F
F
M
M
M
CORN OIL
Page 1169
Pentachloroanisole (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05037-04
C56520
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/30/1984
SO
1825-21-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE 9 SSAC
03 - VEHICLE 15 SSAC
04 - VEHICLE CONTROL
05 - VEHICLE 9 SSAC
06 - VEHICLE 15 SSAC
07 - 40 MG/KG
08 - 40 MG/KG 9 SSAC
09 - 40 MG/KG 15 SSAC
10 - 40 MG/KG
11 - 40 MG/KG 9 SSAC
12 - 40 MG/KG 15 SSAC
13 - 20 MG/KG
14 - 20 MG/KG 9 SSAC
15 - 20 MG/KG 15 SSAC
16 - 20 MG/KG
17 - 20 MG/KG 9 SSAC
18 - 20 MG/KG 15 SSAC
V
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
F
F
F
M
M
M
F
F
F
M
M
M
F
F
F
CORN OIL
Page 1170
Pentachlorobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05139-03
C61847A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/12/1987
MA
608-93-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 33 PPM
04 - 33 PPM
05 - 100 PPM
06 - 100 PPM
07 - 330 PPM
08 - 330 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 2000 PPM
12 - 2000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1171
Pentachlorobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05139-04
C61847A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/05/1987
MA
608-93-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 33 PPM
04 - 33 PPM
05 - 100 PPM
06 - 100 PPM
07 - 330 PPM
08 - 330 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 2000 PPM
12 - 2000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1172
Pentachlorophenol, Dowicide EC-7
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05074-01
C55389
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/12/1982
BC
87-86-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 600 PPM
08 - 600 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1173
Pentachlorophenol, purified
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
FEED
89002-01
C89002
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/01/1992
BC
87-86-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 200 PPM
04 - 200 PPM
05 - 400 PPM
06 - 400 PPM
07 - 800 PPM
08 - 800 PPM
09 - 1600 PPM
10 - 1600 PPM
11 - 3200 PPM
12 - 3200 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1174
Pentachlorophenol, purified (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
89002-02
C89002
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/23/1992
BC
87-86-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 200 PPM
04 - 200 PPM
05 - 400 PPM
06 - 400 PPM
07 - 600 PPM
08 - 600 PPM
09 - 1000 PPM
10 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1175
Pentachlorophenol, technical
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05073-01
C55378
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/14/1982
BC
87-86-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1176
Pentaerythritol tetranitrate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05023-01
C55743
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/19/1982
MA
78-11-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 2.5%
03 - 5.0%
04 - 0.62%
05 - 1.25%
07 - CONTROL
U
T
T
T
T
U
M
M
M
F
F
F
NIH-07
Page 1177
Pentaerythritol tetranitrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05023-02
C55743
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/04/1982
MA
78-11-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 2.5%
03 - 5.0%
04 - 2.5%
05 - 5.0%
07 - CONTROL
U
T
T
T
T
U
M
M
M
F
F
F
NIH-07
Page 1178
Pentaerythritol triacrylate
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
88127-01
C88127
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/20/1996
BC
3524-68-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 200 MG/KG
12 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1179
Pentaerythritol triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
88127-02
C88127
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/21/1996
BC
3524-68-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 200 MG/KG
12 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1180
Pentaerythritol triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
88127-03
C88127
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/16/1996
BC
3524-68-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1181
Pentaerythritol triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
88127-04
C88127
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/18/1996
BC
3524-68-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1182
Pentaerythritol triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
88127-05
C88127
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/16/1996
BC
3524-68-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1183
Pentaerythritol triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
88127-06
C88127B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
07/20/1998
BC
3524-68-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1184
2,3-Pentanedione
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
08010-01
C08010
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
09/13/2010
BN
600-14-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 6.25 ppm
04 - 6.25 ppm
05 - 12.5 ppm
06 - 12.5 ppm
07 - 25 ppm
08 - 25 ppm
09 - 50 ppm
10 - 50 ppm
11 - 100 ppm
12 - 100 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1185
(UNSPECIFIED)
2,3-Pentanedione (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
08010-02
C08010
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/13/2010
BN
600-14-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 6.25 ppm
04 - 6.25 ppm
05 - 12.5 ppm
06 - 12.5 ppm
07 - 25 ppm
08 - 25 ppm
09 - 50 ppm
10 - 50 ppm
11 - 100 ppm
12 - 100 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1186
(UNSPECIFIED)
Perfluorobutane sulfonate (PFBS)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
07040-01
C07040
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/19/2012
BC
375-73-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg/d M
02 - 0mg/kg/d F
03 - 62.6mg/kg/d M
04 - 62.6mg/kg/d F
05 - 125mg/kg/d M
06 - 125mg/kg/d F
07 - 250mg/kg/d M
08 - 250mg/kg/d F
09 - 500mg/kg/d M
10 - 500mg/kg/d F
11 - 1000mg/kg/d M
12 - 1000mg/kg/d F
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1187
Perfluorodecanoic Acid
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
20615-01
C20615
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/07/2012
BC
335-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg/d M
02 - 0mg/kg/d F
03 - 0.156mg/kg/d M
04 - 0.156mg/kg/d F
05 - 0.312mg/kg/d M
06 - 0.312mg/kg/d F
07 - 0.625mg/kg/d M
08 - 0.625mg/kg/d F
09 - 1.25mg/kg/d M
10 - 1.25mg/kg/d F
11 - 2.5mg/kg/d M
12 - 2.5mg/kg/d F
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1188
Perfluorodecanoic acid PFDA
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
92006-99
I92006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
03/29/2011
VC
335-76-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 0.125 mg/kg
03 - .25 mg/kg
04 - .5 mg/kg
05 - 1 mg/kg
06 - 2 mg/kg
07 - CPS 50 mg/kg
V
T
T
T
T
T
P
F
F
F
F
F
F
F
DEIONIZED WATER
Page 1189
Perfluorohexane sulfonate potassium salt (PFHSKslt)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
06100-01
C06100
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/09/2012
BC
3871-99-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg/d M
02 - 0mg/kg/d F
03 - .625mg/kg/d M
04 - 3.12mg/kg/d F
05 - 1.25mg/kg/d M
06 - 6.25mg/kg/d F
07 - 2.5mg/kg/d M
08 - 12.5mg/kg/d F
09 - 5mg/kg/d M
10 - 25mg/kg/d F
11 - 10mg/kg/d M
12 - 50mg/kg/d F
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1190
Perfluorohexanoic acid (PFHXA)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
20613-01
C20613
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/17/2012
BC
307-24-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg/d M
02 - 0mg/kg/d F
03 - 62.6mg/kg/d M
04 - 62.6mg/kg/d F
05 - 125mg/kg/d M
06 - 125mg/kg/d F
07 - 250mg/kg/d M
08 - 250mg/kg/d F
09 - 500mg/kg/d M
10 - 500mg/kg/d F
11 - 1000mg/kg/d M
12 - 1000mg/kg/d F
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1191
Perfluorononanoic Acid
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
04049-01
C04049
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/02/2012
BC
375-95-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg/d M
02 - 0 mg/kg/d F
03 - 0.625mg/kg/d M
04 - 1.56mg/kg/d F
05 - 1.25 mg/kg/d M
06 - 3.12mg/kg/d F
07 - 2.5 mg/kg/d M
08 - 6.25mg/kg/d F
09 - 5 mg/kg/d M
10 - 12.5mg/kg/d F
11 - 10 mg/kg/d M
12 - 25mg/kg/d F
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1192
Perfluorooctane Sulfonate
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
20617-01
C20617
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/24/2012
BC
1763-23-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg/d M
02 - 0mg/kg/d F
03 - .312mg/kg/d M
04 - .312mg/kg/d F
05 - .625mg/kg/d M
06 - .625mg/kg/d F
07 - 1.25mg/kg/d M
08 - 1.25mg/kg/d F
09 - 2.5mg/kg/d M
10 - 2.5mg/kg/d F
11 - 5mg/kg/d M
12 - 5mg/kg/d F
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1193
Perfluorooctanoic Acid
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
20614-01
C20614
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/27/2008
BC
335-67-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0/0 ppm
02 - 0/0 ppm
03 - 0/150 ppm
04 - 0/300 ppm
05 - 150/150 ppm
06 - 150/300 ppm
07 - 0/300 ppm
08 - 0/1000 ppm
09 - 300/300 ppm
10 - 300/1000 ppm
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1194
Perfluorooctanoic Acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
20614-02
C20614B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
07/27/2009
BC
335-67-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0/0 ppm
02 - 300/0 ppm
03 - 0/20 ppm
04 - 300/20 ppm
05 - 0/40 ppm
06 - 300/40 ppm
07 - 0/80 ppm
08 - 300/80 ppm
V
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
NTP 2000 (IRRADIATED)
Page 1195
Perfluorooctanoic Acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
91070-01
C91070B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/31/2012
BC
335-67-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg/d M
02 - 0 mg/kg/d F
03 - 0.625 mg/kg/d M
04 - 6.25mg/kg/d F
05 - 1.25 mg/kg/d M
06 - 12.5mg/kg/d F
07 - 2.5 mg/kg/d M
08 - 25 mg/kg/d F
09 - 5 mg/kg/d M
10 - 50 mg/kg/d F
11 - 10 mg/kg/d M
12 - 100 mg/kg/d F
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1196
Peroxisome project (Dibutyl phthalate)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
93027-01
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
04/12/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 10,000 PPM
06 - 20,000 PPM
U
T
T
T
T
T
M
M
M
M
M
M
NIH-07
Page 1197
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-11
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/15/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 10,000 PPM
06 - 20,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1198
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-12
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/16/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 10,000 PPM
06 - 20,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1199
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-13
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/13/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 1000 PPM
02 - 2500_PPM
03 - 5000_PPM
T
T
T
M
M
M
NTP-2000
Page 1200
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-14
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/22/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 10,000 PPM
06 - 20,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1201
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-15
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/23/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 10,000 PPM
06 - 20,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1202
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-16
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/22/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 1000 PPM
02 - 5000 PPM
03 - 20,000 PPM
T
T
T
M
M
M
NTP-2000
Page 1203
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-17
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
09/08/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 10,000 PPM
06 - 20,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1204
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-18
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
09/09/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1000 PPM
03 - 2500 PPM
04 - 5000 PPM
05 - 10,000 PPM
06 - 20,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1205
Peroxisome project (Dibutyl phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-19
C93027A
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
09/06/1994
BC
84-74-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 1000 PPM
02 - 5000 PPM
03 - 20,000 PPM
T
T
T
M
M
M
NTP-2000
Page 1206
Peroxisome project (2,4-Dichlorophenoxyacetic acid)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
93027-03
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
05/11/1994
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 12 PPM
03 - 100 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 5000 PPM
U
T
T
T
T
T
M
M
M
M
M
M
NIH-07
Page 1207
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-41
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/23/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 17 PPM
03 - 83 PPM
04 - 250 PPM
05 - 750 PPM
06 - 1250 PPM
07 - 2500 PPM
V
T
T
T
T
T
T
M
M
M
M
M
M
M
NTP-2000
Page 1208
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-42
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/24/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 17 PPM
03 - 83 PPM
04 - 250 PPM
05 - 750 PPM
06 - 1250 PPM
07 - 2500 PPM
V
T
T
T
T
T
T
M
M
M
M
M
M
M
NTP-2000
Page 1209
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-43
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/21/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 83 PPM
02 - 250 PPM
03 - 1250 PPM
T
T
T
M
M
M
NTP-2000
Page 1210
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-44
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/02/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 12 PPM
03 - 28 PPM
04 - 83 PPM
05 - 250 PPM
06 - 700 PPM
07 - 1680 PPM
V
T
T
T
T
T
T
M
M
M
M
M
M
M
NTP-2000
Page 1211
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-45
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/03/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 12 PPM
03 - 28 PPM
04 - 83 PPM
05 - 250 PPM
06 - 700 PPM
07 - 1680 PPM
V
T
T
T
T
T
T
M
M
M
M
M
M
M
NTP-2000
Page 1212
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-46
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/28/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 28 PPM
02 - 83 PPM
03 - 250 PPM
T
T
T
M
M
M
NTP-2000
Page 1213
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-47
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
03/06/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 12 PPM
03 - 100 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 5000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1214
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-48
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
03/10/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 12 PPM
03 - 100 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 5000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1215
Peroxisome project (2,4-Dichlorophenoxyacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-49
C93027C
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
03/09/1995
BC
94-75-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 100 PPM
02 - 1000 PPM
03 - 5000 PPM
T
T
T
M
M
M
NTP-2000
Page 1216
Peroxisome project (Gemfibrozil)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
93027-02
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
04/18/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1500 PPM
03 - 3000 PPM
04 - 6000 PPM
05 - 12,000 PPM
06 - 24,000 PPM
U
T
T
T
T
T
M
M
M
M
M
M
NIH-07
Page 1217
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-21
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/30/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 10 PPM
03 - 100 PPM
04 - 1000 PPM
05 - 8000 PPM
06 - 16,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1218
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-22
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/29/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 10 PPM
03 - 100 PPM
04 - 1000 PPM
05 - 8000 PPM
06 - 16,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1219
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-23
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/28/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 100 PPM
02 - 1000 PPM
03 - 16,000 PPM
T
T
T
M
M
M
NTP-2000
Page 1220
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-24
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/14/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - O PPM
02 - 10 PPM
03 - 100 PPM
04 - 1000 PPM
05 - 4000 PPM
06 - 8000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1221
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-25
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/13/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 10 PPM
03 - 100 PPM
04 - 1000 PPM
05 - 4000 PPM
06 - 8000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1222
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-26
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/12/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 100 PPM
02 - 1000 PPM
03 - 8000 PPM
T
T
T
M
M
M
NTP-2000
Page 1223
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-27
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
10/21/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 100 PPM
03 - 1000 PPM
04 - 6000 PPM
05 - 12,000 PPM
06 - 24,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1224
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-28
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
10/20/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 100 PPM
03 - 1000 PPM
04 - 6000 PPM
05 - 12,000 PPM
06 - 24,000 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1225
Peroxisome project (Gemfibrozil) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-29
C93027B
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
10/20/1994
BC
25812-30-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 100 PPM
02 - 12,000 PPM
03 - 24,000 PPM
T
T
T
M
M
M
NTP-2000
Page 1226
Peroxisome project (WY-14643)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
93027-04
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
05/17/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 10 PPM
03 - 100 PPM
04 - 500 PPM
05 - 1000 PPM
06 - 5000 PPM
U
T
T
T
T
T
M
M
M
M
M
M
NIH-07
Page 1227
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
93027-05
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/18/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 10 PPM
03 - 50 PPM
04 - 100 PPM
05 - 500 PPM
06 - 1000 PPM
U
T
T
T
T
T
M
M
M
M
M
M
NIH-07
Page 1228
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-31
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
12/01/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5 PPM
03 - 10 PPM
04 - 50 PPM
05 - 100 PPM
06 - 500 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1229
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-32
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/30/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5 PPM
03 - 10 PPM
04 - 50 PPM
05 - 100 PPM
06 - 500 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1230
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-33
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/29/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 50 PPM
02 - 100 PPM
03 - 500 PPM
T
T
T
M
M
M
NTP-2000
Page 1231
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-34
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/08/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5 PPM
03 - 10 PPM
04 - 50 PPM
05 - 100 PPM
06 - 500 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1232
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-35
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/07/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5 PPM
03 - 10 PPM
04 - 50 PPM
05 - 100 PPM
06 - 500 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1233
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-36
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/06/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 50 PPM
02 - 100 PPM
03 - 500 PPM
T
T
T
M
M
M
NTP-2000
Page 1234
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-37
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
12/15/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5 PPM
03 - 10 PPM
04 - 50 PPM
05 - 100 PPM
06 - 500 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1235
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-38
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
12/14/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 5 PPM
03 - 10 PPM
04 - 50 PPM
05 - 100 PPM
06 - 500 PPM
V
T
T
T
T
T
M
M
M
M
M
M
NTP-2000
Page 1236
Peroxisome project (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
93027-39
C93027D
SPECIES:
1ST DOSE:
LAB:
CAS:
HAMSTERS, SYRIAN
12/15/1994
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 50 PPM
02 - 100 PPM
03 - 500 PPM
T
T
T
M
M
M
NTP-2000
Page 1237
Pesticide/fertilizer contamination--mixture 2
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
89009-01
C89009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/18/1990
SO
PESTFERTMIX2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0.1X
04 - 0.1X
05 - 1X
06 - 1X
07 - 10X
08 - 10X
09 - 100X
10 - 100X
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.05 % PROPYLENE GLYCOL
Page 1238
Pesticide/fertilizer contamination--mixture 2 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
89009-02
C89009
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/23/1990
SO
PESTFERTMIX2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0.1X
04 - 0.1X
05 - 1X
06 - 1X
07 - 10X
08 - 10X
09 - 100X
10 - 100X
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.05 % PROPYLENE GLYCOL
Page 1239
Pesticide/fertilizer contamination--mixture 3
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
89010-01
C89010
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/06/1990
SO
PESTFERTMIX3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0.1X
04 - 0.1X
05 - 1X
06 - 1X
07 - 10X
08 - 10X
09 - 100X
10 - 100X
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.05 % PROPYLENE GLYCOL
Page 1240
Pesticide/fertilizer contamination--mixture 3 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
89010-02
C89010
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/13/1990
SO
PESTFERTMIX3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 0.1X
04 - 0.1X
05 - 1X
06 - 1X
07 - 10X
08 - 10X
09 - 100X
10 - 100X
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.05 % PROPYLENE GLYCOL
Page 1241
Phenolphthalein
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05182-01
C55798
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/28/1987
MB
77-09-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 %
02 - 0 %
03 - 0.3%
04 - 0.3%
05 - 0.6%
06 - 0.6%
07 - 1.2%
08 - 1.2%
09 - 2.5%
10 - 2.5%
11 - 5.0%
12 - 5.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1242
Phenolphthalein (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05182-02
C55798
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/30/1987
MB
77-09-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.3%
04 - 0.3%
05 - 0.6%
06 - 0.6%
07 - 1.2%
08 - 1.2%
09 - 2.5%
10 - 2.5%
11 - 5.0%
12 - 5.0%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1243
Phenolphthalein (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05182-03
C55798B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/13/1991
MA
77-09-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 12000 PPM
04 - 12000 PPM
05 - 25000 PPM
06 - 25000 PPM
07 - 50000 PPM
08 - 50000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1244
Phenolphthalein (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05182-04
C55798B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/27/1990
MA
77-09-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3000 PPM
04 - 3000 PPM
05 - 6000 PPM
06 - 6000 PPM
07 - 12000 PPM
08 - 12000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1245
Phenylbutazone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05063-01
C56531
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/08/1981
MA
50-33-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - 0.05 G/KG
03 - 0.1 G/KG
04 - VEHICLE
05 - 0.05 G/KG
06 - 0.1 G/KG
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1246
Phenylbutazone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05063-02
C56531
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/24/1981
MA
50-33-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - 0.15 G/KG
03 - 0.3 G/KG
04 - VEHICLE
05 - 0.15 G/KG
06 - 0.3 G/KG
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1247
ortho-Phthalaldehyde
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20727-01
C20727
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/19/2009
BN
643-79-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.44 ppm
04 - 0.44 ppm
05 - 0.88 ppm
06 - 0.88 ppm
07 - 1.75 ppm
08 - 1.75 ppm
09 - 3.5 ppm
10 - 3.5 ppm
11 - 7.0 ppm
12 - 7.0 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1248
ortho-Phthalaldehyde (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20727-02
C20727
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/19/2009
BN
643-79-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.44 ppm
04 - 0.44 ppm
05 - 0.88 ppm
06 - 0.88 ppm
07 - 1.75 ppm
08 - 1.75 ppm
09 - 3.5 ppm
10 - 3.5 ppm
11 - 7.0 ppm
12 - 7.0 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1249
beta-Picoline
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20009-01
C20009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/17/2003
BC
108-99-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 78 MG/L
04 - 78 MG/L
05 - 156 MG/L
06 - 156 MG/L
07 - 312 MG/L
08 - 312 MG/L
09 - 625 MG/L
10 - 625 MG/L
11 - 1250 MG/L
12 - 1250 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1250
beta-Picoline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20009-02
C20009
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/20/2003
BC
108-99-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 78 MG/L
04 - 78 MG/L
05 - 156 MG/L
06 - 156 MG/L
07 - 312 MG/L
08 - 312 MG/L
09 - 625 MG/L
10 - 625 MG/L
11 - 1250 MG/L
12 - 1250 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1251
beta-Picoline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20009-03
C20009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/18/2004
BC
108-99-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/l
02 - 0 mg/l
03 - 156.25 mg/l
04 - 156.25 mg/l
05 - 312.5 mg/l
06 - 312.5 mg/l
07 - 625 mg/l
08 - 625 mg/l
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1252
beta-Picoline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20009-04
C20009
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/08/2004
BC
108-99-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/l
02 - 0 mg/l
03 - 312.5 mg/l
04 - 312.5 mg/l
05 - 625 mg/l
06 - 625 mg/l
07 - 1250 mg/l
08 - 1250 mg/l
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1253
beta-Picoline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
20009-98
C20009
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/06/2001
BC
108-99-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1250 PPM
03 - 2500 PPM
04 - 0 PPM
05 - 1250 PPM
06 - 2500 PPM
V
T
T
V
T
T
M
M
M
F
F
F
WATER
Page 1254
beta-Picoline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
20009-99
C20009
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/06/2001
BC
108-99-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 1250 PPM
03 - 2500 PPM
04 - 0 PPM
05 - 1250 PPM
06 - 2500 PPM
V
T
T
V
T
T
M
M
M
F
F
F
WATER
Page 1255
Polybrominated biphenyl mixture (Firemaster FF-1)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05077-01
C53634B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/15/1983
BC
67774-32-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM 0-0
02 - 0 PPM 10-0
03 - 3 PPM 1-1
04 - 10 PPM 0-3
05 - 10 PPM 3-3
06 - 10 PPM 10-3
07 - 30 PPM 0-10
08 - 30 PPM 10-10
09 - 0 PPM 0-0
10 - 0 PPM 10-0
11 - 3 PPM 1-1
12 - 10 PPM 0-3
13 - 10 PPM 3-3
14 - 10 PPM 10-3
15 - 30 PPM 0-10
16 - 30 PPM 10-10
U
U
T
T
T
T
T
T
U
U
T
T
T
T
T
T
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
PURINA 5002 CERTIFIED CHOW
Page 1256
Polybrominated biphenyl mixture (Firemaster FF-1) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05077-02
C53634B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/16/1983
BC
67774-32-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM 0-0
02 - 0 PPM 10-0
03 - 3 PPM 1-1
04 - 10 PPM 0-3
05 - 10 PPM 3-3
06 - 10 PPM 10-3
07 - 30 PPM 0-10
08 - 30 PPM 10-10
09 - 0 PPM 0-0
10 - 0 PPM 10-0
11 - 3 PPM 1-1
12 - 10 PPM 0-3
13 - 10 PPM 3-3
14 - 10 PPM 10-3
15 - 30 PPM 0-10
16 - 30 PPM 10-10
U
U
T
T
T
T
T
T
U
U
T
T
T
T
T
T
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
PURINA 5002 CERTIFIED CHOW
Page 1257
Polysorbate 80 (glycol)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05007-05
C60286
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/18/1982
SO
9005-65-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 5.0%
04 - 5.0%
05 - 2.5%
06 - 2.5%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1258
Polysorbate 80 (glycol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05007-06
C60286
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/25/1982
SO
9005-65-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 5.0%
04 - 5.0%
05 - 2.5%
06 - 2.5%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1259
Polyvinyl alcohol
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
VAGINAL
88066-01
C88066
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/18/1992
AD
9002-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATDCONTROL
02 - VEHICLE CONTROL
03 - 25%
U
V
T
F
F
F
NIH-07
DEIONIZED WATER
Page 1260
Pregnancy Rate Comparison Study
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
NOT APPL
09031-01
C09031
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSDD
10/04/2009
BC
PREGRATECOMP
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - MW(NIH-07)
02 - FW(NIH-07)
03 - Male Pups PND 4
04 - Female Pups PND4
05 - MW(NTP 2000)
06 - FW(NTP 2000)
07 - Male Pups PND 21
08 - FemalePups PND21
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07 (IRRADIATED)
Page 1261
NTP 2000 (IRRADIATED)
NIH-07 (IRRADIATED)
Pregnancy Rate Comparison Study (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
NOT APPL
09031-02
C09031
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSDI
10/04/2009
BC
PREGRATECOMP
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - MW(NIH-07)
02 - FW(NIH-07)
03 - Male Pups PND 4
04 - Female Pups PND4
05 - MW(NTP 2000)
06 - FW(NTP 2000)
07 - Male Pups PND 21
08 - FemalePups PND21
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07 (IRRADIATED)
Page 1262
NTP 2000 (IRRADIATED)
NIH-07 (IRRADIATED)
Prevention 2 (Silymarin + melatonin)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
99014-01
C99014C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
04/06/1999
NE
SILYMARN+MEL
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NTP 2000
02 - .028% MELATONIN
03 - .056% MELATONIN
04 - .112% MELATONIN
05 - .05% SILYMARIN
06 - .10% SILYMARIN
07 - .20% SILYMARIN
08 - .078% SIL+MEL
09 - .312% SIL+MEL
10 - AIN-76A
V
T
T
T
T
T
T
T
T
U
F
F
F
F
F
F
F
F
F
F
NTP-2000
Page 1263
AIN-76A
Prevention 3 (Melatonin)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
20001-01
C20001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
01/18/2000
NE
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - AIN76-A
02 - NTP-2000
03 - MELATONI 17 PPM
04 - MELATONI 35 PPM
05 - MELATONI 70 PPM
06 - MELATONI 140PPM
07 - MELATONI 280PPM
08 - MELATONI 560PPM
U
V
T
T
T
T
T
T
F
F
F
F
F
F
F
F
AIN-76A
NTP-2000
Page 1264
PREVENTION 8 (RESVERATROL)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
20211-01
C20211
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
05/14/2002
NE
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NTP 2000
02 - NTP RESV 600
03 - NTP RESV1200
04 - NTP RESV2400
05 - AIN 93G
06 - AIN RESV 750
07 - AIN RESV1500
08 - AIN RESV3000
09 - NTP SOY 30
10 - AIN SOY 75
V
T
T
T
V
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
NTP-2000
Page 1265
AIN-93G
NTP-2000
AIN-93G
Prevention 7 (feed controls)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
20106-01
C20106
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
07/17/2001
NE
PREVENTION7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NTP2000
02 - OVEC4 NTP2000
03 - OVEC10 NTP2000
04 - OVEC16 NTP2000
05 - AIN93G
06 - OVEC4 AIN93G
07 - OVEC10 AIN93G
08 - OVEC16 AIN93G
U
U
U
U
U
U
U
U
F
F
F
F
F
F
F
F
NTP-2000
Page 1266
AIN-93G
Prevention 4 (Indole-3-carbinol)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
20010-01
C20010A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
05/10/2000
NE
700-06-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - AIN-76A
02 - NTP 2000
03 - I3C 0.05
04 - I3C 0.10
05 - I3C 0.20
06 - CURCUMIN 0.25
07 - CURCUMIN 0.50
08 - CURCUMIN 1.0
09 - MELATONI 0.28
10 - MEL+I3C .028+0.1
11 - MEL+CUR .028+0.5
U
V
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
AIN-76A
NTP-2000
Page 1267
Prevention 6 (isoflavone concentrate)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
20104-01
C20104B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
10/16/2001
NE
ISOFLAVCONCN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NTP2000+LWSOYPTN
02 - NTP2000 + ISO 30
03 - NTP 2000+ISO 140
04 - NTP 2000+ISO 460
05 - AIN 93G
06 - AIN 93G +ISO 75
07 - AIN 93G +ISO 220
08 - AIN 93G +ISO 660
09 - NTP 2000
V
T
T
T
P
T
T
T
U
F
F
F
F
F
F
F
F
F
NTP-2000
Page 1268
AIN-93G
NTP-2000
Prevention 1 (Linolenic acid + melatonin)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
98003-01
C98003
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
03/31/1998
NE
LINOACID+MEL
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NTP2000 +.2ML CO
02 - .10 LINO+ 2.2 ME
03 - .20MLS LINO ACI
04 - .10ML LINO ACI
05 - .05 LINO ACI
06 - 4.4MG MELATONI
07 - 2.2MG MELATONI
08 - 1.1MG MELATONI
09 - AIN 76A +.2ML CO
10 - NTP 2000FEED
V
T
T
T
T
T
T
T
N
U
F
F
F
F
F
F
F
F
F
F
CORN OIL, NTP 2000 FEED + CORN OIL
LINOLENIC ACID
(UNSPECIFIED)
CORN OIL
Page 1269
(UNSPECIFIED)
Prevention 5 (Melatonin)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
20015-01
C20015
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
12/12/2000
NE
73-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - AIN-76A
02 - AIN-76A MEL 70
03 - AIN-76A MEL 280
04 - AIN-76A MEL 560
05 - AIN-93G
06 - AIN-93G MEL 70
07 - AIN-93G MEL 280
08 - AIN-93G MEL 560
09 - NTP-2000
10 - NTP 2000MEL 70
11 - NTP 2000MEL 280
12 - NTP 2000MEL 560
N
T
T
T
N
T
T
T
N
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
AIN-76A
Page 1270
AIN-93G
NTP-2000
Prevention 10 (Soy isoflavone concentrate)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
20223-01
C20223
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
12/17/2002
NE
PREVENTION10
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NTP 2000
02 - ISO 30 MG/KG
03 - ISO 140MG/KG
04 - ISO 460MG/KG
V
T
T
T
F
F
F
F
NTP-2000
Page 1271
Primidone (primaclone)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88035-03
C88035
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/17/1990
BC
125-33-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.03%
04 - 0.03%
05 - 0.06%
06 - 0.06%
07 - 0.13%
08 - 0.13%
09 - 0.25%
10 - 0.25%
11 - 0.5%
12 - 0.5%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1272
Primidone (primaclone) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
88035-04
C88035
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/11/1990
BC
125-33-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.03%
04 - 0.03%
05 - 0.06%
06 - 0.06%
07 - 0.13%
08 - 0.13%
09 - 0.25%
10 - 0.25%
11 - 0.5%
12 - 0.5%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1273
Primidone (primaclone) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88035-05
C88035
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/06/1992
BC
125-33-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.06%
04 - 0.06%
05 - 0.13%
06 - 0.13%
07 - 0.25%
08 - 0.25%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1274
Primidone (primaclone) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
88035-06
C88035
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/16/1992
BC
125-33-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.03%
04 - 0.03%
05 - 0.06%
06 - 0.06%
07 - 0.13%
08 - 0.13%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1275
Probenecid
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05030-01
C56097
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/27/1982
MA
57-66-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE MALE
02 - VEHICLE FEMALE
03 - .1 G/KG LM
04 - .4 G/KG HM
05 - .1 G/KG LF
06 - .4 G/KG HF
V
V
T
T
T
T
M
F
M
M
F
F
CORN OIL
Page 1276
(UNSPECIFIED)
Probenecid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05030-02
C56097
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/10/1982
MA
57-66-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE MALE
02 - VEHICLE FEMALE
03 - .1 G/KG LM
04 - .4 G/KG HM
05 - .1 G/KG LF
06 - .4 G/KG HF
V
V
T
T
T
T
M
F
M
M
F
F
CORN OIL
Page 1277
(UNSPECIFIED)
CORN OIL
(UNSPECIFIED)
CORN OIL
Promethazine hydrochloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05108-01
C60673B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/05/1985
MA
58-33-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE MALE
02 - 8.3 MG/KG
03 - 16.6 MG/KG
04 - 33.3 MG/KG
06 - VEHICLE FEMALE
07 - 8.3 MG/KG
08 - 16.6 MG/KG
09 - 33.3 MG/KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
DEIONIZED WATER
Page 1278
Promethazine hydrochloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05108-02
C60673B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/29/1985
MA
58-33-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE MALE
02 - 11.25 MG/KG
03 - 22.5 MG/KG
04 - 45.0 MG/KG
06 - VEHICLE FEMALE
07 - 3.75 MG/KG
08 - 7.5 MG/KG
09 - 15.0 MG/KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
DEIONIZED WATER
Page 1279
Propargyl alcohol
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
97008-01
C97008
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/11/2000
BN
107-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31.3 PPM
04 - 31.3 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
09 - 250 PPM
10 - 250 PPM
11 - 500 PPM
12 - 500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1280
Propargyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
97008-02
C97008
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/11/2000
BN
107-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 31.3 PPM
04 - 31.3 PPM
05 - 62.5 PPM
06 - 62.5 PPM
07 - 125 PPM
08 - 125 PPM
09 - 250 PPM
10 - 250 PPM
11 - 500 PPM
12 - 500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1281
Propargyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
97008-03
C97008
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/13/2000
BN
107-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 4 PPM
04 - 4 PPM
05 - 8 PPM
06 - 8 PPM
07 - 16 PPM
08 - 16 PPM
09 - 32 PPM
10 - 32 PPM
11 - 64 PPM
12 - 64 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1282
Propargyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
97008-04
C97008
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/13/2000
BN
107-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 4 PPM
04 - 4 PPM
05 - 8 PPM
06 - 8 PPM
07 - 16 PPM
08 - 16 PPM
09 - 32 PPM
10 - 32 PPM
11 - 64 PPM
12 - 64 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1283
Propargyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
97008-05
C97008
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/01/2001
BN
107-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 16 PPM
04 - 16 PPM
05 - 32 PPM
06 - 32 PPM
07 - 64 PPM
08 - 64 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1284
Propargyl alcohol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
97008-06
C97008
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/17/2001
BN
107-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 8 PPM
04 - 8 PPM
05 - 16 PPM
06 - 16 PPM
07 - 32 PPM
08 - 32 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1285
Propylene glycol mono-t-butyl ether
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
90004-01
C90004
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/22/1996
BN
57018-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 150 PPM
06 - 150 PPM
07 - 300 PPM
08 - 300 PPM
09 - 600 PPM
10 - 600 PPM
11 - 1200 PPM
12 - 1200 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1286
Propylene glycol mono-t-butyl ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
90004-02
C90004
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/22/1996
BN
57018-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 150 PPM
06 - 150 PPM
07 - 300 PPM
08 - 300 PPM
09 - 600 PPM
10 - 600 PPM
11 - 1200 PPM
12 - 1200 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1287
Propylene glycol mono-t-butyl ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
90004-03
C90004
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, NCI BLK RTR
07/22/1996
BN
57018-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 75 PPM
03 - 150 PPM
04 - 300 PPM
05 - 600 PPM
06 - 1200 PPM
U
T
T
T
T
T
M
M
M
M
M
M
AIR
Page 1288
Propylene glycol mono-t-butyl ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
90004-04
C90004
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/09/1996
BN
57018-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 150 PPM
06 - 150 PPM
07 - 300 PPM
08 - 300 PPM
09 - 600 PPM
10 - 600 PPM
11 - 1200 PPM
12 - 1200 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1289
Propylene glycol mono-t-butyl ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
90004-05
C90004
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/09/1996
BN
57018-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 150 PPM
06 - 150 PPM
07 - 300 PPM
08 - 300 PPM
09 - 600 PPM
10 - 600 PPM
11 - 1200 PPM
12 - 1200 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1290
Propylene glycol mono-t-butyl ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
90004-06
C90004
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/29/1997
BN
57018-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 300 PPM
06 - 300 PPM
07 - 1200 PPM
08 - 1200 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1291
Propylene glycol mono-t-butyl ether (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
90004-07
C90004
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/06/1997
BN
57018-52-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 75 PPM
04 - 75 PPM
05 - 300 PPM
06 - 300 PPM
07 - 1200 PPM
08 - 1200 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1292
Pulegone
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99020-01
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/13/2001
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1293
Pulegone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99020-02
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/20/2001
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 18.75 MG/KG
04 - 18.75 MG/KG
05 - 37.5 MG/KG
06 - 37.5 MG/KG
07 - 75 MG/KG
08 - 75 MG/KG
09 - 150 MG/KG
10 - 150 MG/KG
11 - 300 MG/KG
12 - 300 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1294
Pulegone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99020-03
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/18/2002
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 9.375 MG/KG
04 - 9.375 MG/KG
05 - 18.75 MG/KG
06 - 18.75 MG/KG
07 - 37.5 MG/KG
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 150 MG/KG
12 - 150 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1295
Pulegone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99020-04
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/25/2002
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 9.375 MG/KG
04 - 9.375 MG/KG
05 - 18.75 MG/KG
06 - 18.75 MG/KG
07 - 37.5 MG/KG
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 150 MG/KG
12 - 150 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1296
Pulegone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99020-05
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/09/2003
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 18.75 MG/KG
04 - 37.5 MG/KG
05 - 37.5 MG/KG
06 - 75.0 MG/KG
07 - 75 MG/KG Stop
08 - 150 MG/KG Stop
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1297
Pulegone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99020-06
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/14/2003
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1298
Pulegone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99020-98
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/25/2002
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 9.375 MG/KG
04 - 9.375 MG/KG
05 - 18.75 MG/KG
06 - 18.75 MG/KG
07 - 37.5 MG/KG
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 150 MG/KG
12 - 150 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1299
Pulegone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99020-99
C99020
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/18/2002
BC
89-82-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 9.375 MG/KG
04 - 9.375 MG/KG
05 - 18.75 MG/KG
06 - 18.75 MG/KG
07 - 37.5 MG/KG
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 150 MG/KG
12 - 150 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1300
Pyridine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
10532-01
C10532
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/04/2010
BC
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 6.25 mg/kg
03 - 12.5 mg/kg
04 - 25 mg/kg
05 - 50 mg/kg
06 - 100 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
DEIONIZED WATER
Page 1301
Pyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
55301-01
C55301B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/20/1989
MA
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 50 PPM
04 - 50 PPM
05 - 100 PPM
06 - 100 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
11 - 1000 PPM
12 - 1000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1302
Pyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
55301-02
C55301B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/22/1990
MA
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 50 PPM
04 - 50 PPM
05 - 100 PPM
06 - 100 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
11 - 1000 PPM
12 - 1000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1303
Pyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
55301-03
C55301B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, WISTAR OUTBR
02/28/1990
MA
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 50 PPM
03 - 100 PPM
04 - 250 PPM
05 - 500 PPM
06 - 1000 PPM
U
T
T
T
T
T
M
M
M
M
M
M
DEIONIZED WATER
Page 1304
Pyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
55301-04
C55301B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/03/1991
MA
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 250 PPM
04 - 125 PPM
05 - 500 PPM
06 - 250 PPM
07 - 1000 PPM
08 - 500 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1305
Pyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
55301-05
C55301B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/23/1991
MA
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1306
Pyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
55301-06
C55301B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, WISTAR OUTBR
05/14/1991
MA
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 100 PPM
03 - 200 PPM
04 - 400 PPM
U
T
T
T
M
M
M
M
DEIONIZED WATER
Page 1307
Pyrogallol
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99032-01
C99032
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/03/2003
BC
87-66-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 9.5 MG/KG
04 - 9.5 MG/KG
05 - 18.75 MG/KG
06 - 18.75 MG/KG
07 - 37.5 MG/KG
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 150 MG/KG
12 - 150 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1308
Pyrogallol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99032-02
C99032
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/05/2003
BC
87-66-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 38 MG/KG
04 - 38 MG/KG
05 - 75 MG/KG
06 - 75 MG/KG
07 - 150 MG/KG
08 - 150 MG/KG
09 - 300 MG/KG
10 - 300 MG/KG
11 - 600 MG/KG
12 - 600 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1309
Pyrogallol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
99032-03
C99032
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/15/2004
BC
87-66-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 5 MG/KG
04 - 5 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 75 MG/KG
08 - 75 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1310
Pyrogallol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
99032-04
C99032
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/20/2004
BC
87-66-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 5 MG/KG
04 - 5 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 75 MG/KG
08 - 75 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1311
Pyrogallol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
99032-99
C99032
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/03/2003
BC
87-66-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 9.5 MG/KG
04 - 9.5 MG/KG
05 - 18.75 MG/KG
06 - 18.75 MG/KG
07 - 37.5 MG/KG
08 - 37.5 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 150 MG/KG
12 - 150 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1312
Phase 1 KTD 2007
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
08012-01
R08012
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
03/15/2008
TI
PH1KTD2007
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F0-Control
02 - F0-Low Dose
03 - F0-Mid Dose
04 - F0-High Dose
V
T
T
T
F
F
F
F
CORN OIL
Page 1313
Phase 1 KTD 2007 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
08012-02
R08012
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
04/20/2008
TI
PH1KTD2007
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1-Ctrl-Bred
02 - F1-Ctrl-Bred
03 - F1-Low-Bred
04 - F1-Low-Bred
05 - F1-Mid-Bred
06 - F1-Mid-Bred
07 - F1-High-Bred
08 - F1-High-Bred
11 - F1-Ctrl-Not Bred
12 - F1-Ctrl-Not Bred
13 - F1-Low-Not Bred
14 - F1-Low-Not Bred
15 - F1-Mid- Not Bred
16 - F1-Mid-Not Bred
17 - F1-High-NotBred
18 - F1-High-NotBred
V
V
T
T
T
T
T
T
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1314
Phase 1 KTD 2007 (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
08012-03
R08012
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
10/07/2008
TI
PH1KTD2007
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F2b-Ctrl-Adult
02 - F2b-Ctrl-Adult
03 - F2b-Low-Adult
04 - F2b-Low-Adult
05 - F2b-Mid-Adult
06 - F2b-Mid-Adult
07 - F2b-High-Adult
08 - F2b-High-Adult
11 - F2bCtrl-Pup
12 - F2bCtrl-Pup
13 - F2b-Low-Pup
14 - F2b-Low-Pup
15 - F2b-Mid-Pup
16 - F2b-Mid-Pup
18 - F2b-High-Pup
V
V
T
T
T
T
T
T
V
V
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
F
CORN OIL
Page 1315
Quercetin
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05033-01
C60106
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/23/1982
MA
117-39-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL UM
02 - 0.1% LM
03 - 1.0% MM
04 - 4.0% HM
05 - CONTROL UF
06 - 0.1% LF
07 - 1.0% MF
08 - 4.0% HF
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1316
Rat feed study (TGMX rat liver evaluation)
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
FEED
20540-01
C20540A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
01/31/2006
BC
TGMXRALVFEED
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - AFA 1ppm
03 - APAP 3,000 ppm
04 - DBANQ 5,000 ppm
05 - VITC 25,000 ppm
06 - TRYP 25,000 ppm
V
T
T
T
T
T
M
M
M
M
M
M
NTP 2000 (IRRADIATED)
Page 1317
Reserpine
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
50157-04
C50157B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.M
01/15/1990
MA
50-55-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5 PPM
04 - 5 PPM
05 - 10 PPM
06 - 10 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1318
Reserpine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
50157-05
C50157B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
02/12/1990
MA
50-55-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5 PPM
04 - 5 PPM
05 - 10 PPM
06 - 10 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1319
Reserpine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
50157-06
C50157B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.SH
03/12/1990
MA
50-55-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 5 PPM
04 - 5 PPM
05 - 10 PPM
06 - 10 PPM
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1320
Resorcinol
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05704-01
C05970A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/12/1982
IR
108-46-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL M
02 - 112MG/KG MALE
03 - 225MG/KG MALE
04 - CONTROL F
05 - 112MG/KG FEMALE
06 - 225MG/KG FEMALE
V
T
T
V
T
T
M
M
M
F
F
F
DEIONIZED WATER
Page 1321
Resorcinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05704-02
C05970A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/19/1982
IR
108-46-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 112MG/KG MALE
03 - 225MG/KG MALE
04 - CONTROL FEMALE
05 - 112MG/KG FEMALE
06 - 225MG/KG FEMALE
V
T
T
V
T
T
M
M
M
F
F
F
DEIONIZED WATER
Page 1322
Resorcinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05704-03
C05970A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/11/1983
IR
108-46-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE/CONTROL
02 - 50 MG/KG
03 - 100 MG/KG
04 - 150 MG/KG
V
T
T
T
F
F
F
F
DEIONIZED WATER
Page 1323
Resveratrol
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20323-01
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
10/16/2006
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 78 mg/kg
04 - 78 mg/kg
05 - 156 mg/kg
06 - 156 mg/kg
07 - 312.5 mg/kg
08 - 312.5 mg/kg
09 - 625 mg/kg
10 - 625 mg/kg
11 - 1250 mg/kg
12 - 1250 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1324
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20323-02
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/16/2006
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 156 mg/kg
04 - 156 mg/kg
05 - 312 mg/kg
06 - 312 mg/kg
07 - 625 mg/kg
08 - 625 mg/kg
09 - 1250 mg/kg
10 - 1250 mg/kg
11 - 2500 mg/kg
12 - 2500 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1325
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90 DAY W/PN EXP
GAVAGE
20323-03
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/24/2008
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 78 mg/kg
04 - 78 mg/kg
05 - 156 mg/kg
06 - 156 mg/kg
07 - 312.5 mg/kg
08 - 312.5 mg/kg
09 - 625 mg/kg
10 - 625 mg/kg
11 - 1250 mg/kg
12 - 1250 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1326
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20323-04
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/22/2008
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 156 mg/kg
04 - 156 mg/kg
05 - 312 mg/kg
06 - 312 mg/kg
07 - 625 mg/kg
08 - 625 mg/kg
09 - 1250 mg/kg
10 - 1250 mg/kg
11 - 2500 mg/kg
12 - 2500 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1327
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20323-05
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/07/2012
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 312.5 mg/kg
04 - 312.5 mg/kg
05 - 625 mg/kg
06 - 625 mg/kg
07 - 1250 mg/kg
08 - 1250 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1328
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20323-06
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
05/21/2012
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 625 mg/kg
04 - 625 mg/kg
05 - 1250 mg/kg
06 - 1250 mg/kg
07 - 2500 mg/kg
08 - 2500 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1329
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
20323-94
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
04/15/2012
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg Fpup
02 - 312.5 mg/kg Fpup
03 - 625 mg/kg Fpup
04 - 1250 mg/kg Fpup
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1330
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
20323-95
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
04/15/2012
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg Mpup
02 - 312.5 mg/kg Mpup
03 - 625 mg/kg Mpup
04 - 1250 mg/kg Mpup
V
T
T
T
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1331
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
20323-96
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
04/15/2012
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg LAC
02 - 312.5 mg/kg LAC
03 - 625 mg/kg LAC
04 - 1250 mg/kg LAC
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1332
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
GAVAGE
20323-97
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
03/25/2012
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg GES
02 - 312.5 mg/kg GES
03 - 625 mg/kg GES
04 - 1250 mg/kg GES
V
T
T
T
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1333
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
20323-98
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/14/2008
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 78 mg/kg
03 - 156 mg/kg
04 - 312.5 mg/kg
05 - 625 mg/kg
06 - 1250 mg/kg
V
T
T
T
T
T
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1334
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
20323-99
C20323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
11/14/2008
BC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 78 mg/kg
03 - 156 mg/kg
04 - 312.5 mg/kg
05 - 625 mg/kg
06 - 1250 mg/kg
V
T
T
T
T
T
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1335
Resveratrol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
20704-99
IM20704
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/13/2007
VC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle Control
02 - 156 mg/kg
03 - 312 mg/kg
04 - 625 mg/kg
05 - 1250 mg/kg
06 - 2500 mg/kg
07 - CPS Pos Cont
V
T
T
T
T
T
P
M
M
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1336
PHOSPHATE BUFFERED SALINE
Retinoid project 2 (4-(Hydroxyphenyl)retinamide)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
93028-02
C93028B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
06/21/1994
NE
65646-68-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL VIT/ADEF
02 - CONTROL 1000IUKG
03 - 4-HPR 392MG/KG
04 - 4-HPR 783MG/KG
05 - 4-HPR 1566MGKG
U
V
T
T
T
F
F
F
F
F
(UNSPECIFIED)
CONTROL DIET (1000 IU/KG VITAMIN A)
(UNSPECIFIED)
Page 1337
Retinoid project 1
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
93028-01
C93028
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
10/21/1993
NE
RETINOID1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL DIET
02 - VITAMIN A DEF
03 - RETINYL ACETATE
04 - 4-HPR 1G/KG
05 - CANTHAX 5G/KG
U
T
T
T
T
F
F
F
F
F
CONTROL DIET (VITAMIN A 600 IU/KG)
(UNSPECIFIED)
Page 1338
Retinoid project 3 (Retinol acetate)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
93028-03
C93028C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
03/21/1995
NE
127-47-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NIH-07 DIET
02 - NTP-2000DIET
03 - RO4087571500MGKG
04 - RETL ACT41 MG/KG
05 - RETL ACT82 MG/KG
06 - RETL ACT164MG/KG
V
T
T
T
T
T
F
F
F
F
F
F
NIH-07
(UNSPECIFIED)
NIH-07
Page 1339
Retinoid project 4 (4-(Hydroxyphenyl)retinamide)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
93028-04
C93028E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
11/07/1995
NE
65646-68-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - AIN 76-A
02 - NIH 07
03 - NTP-2000
U
U
U
F
F
F
(UNSPECIFIED)
Page 1340
Retinoid project 5 (4-(Hydroxyphenyl)retinamide)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
93028-05
C93028F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
11/14/1995
NE
65646-68-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - AIN76-A
02 - NIH-07
03 - NTP-2000
04 - RO4087571290MGKG
05 - RO408757860MG/KG
06 - 4-HPR 1958MGKG
U
U
V
T
T
T
F
F
F
F
F
F
(UNSPECIFIED)
Page 1341
NTP-2000
Retinoid project 6 (Arotinoid)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
93028-06
C93028I
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
05/20/1997
NE
125533-88-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - AIN 76-A
02 - NTP 2000
03 - RO 1084 MG/KG
04 - RO 650 MG/KG
05 - HPR 2741MG/KG
U
V
T
T
T
F
F
F
F
F
(UNSPECIFIED)
NTP-2000
Page 1342
Retinoid project 6 (Arotinoid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SIX MONTH EXPOS.
FEED
93028-07
C93028I
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.NK
04/22/1997
NE
125533-88-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - AIN 76-A
02 - NTP 2000
03 - RO 1084 MG/KG
04 - RO 650 MG/KG
05 - HPR 2741MG/KG
U
V
T
T
T
F
F
F
F
F
(UNSPECIFIED)
NTP-2000
Page 1343
All-trans-retinyl palmitate
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
SKIN
01012-01
C01012
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SKH-1/NCTR
07/22/2013
NR
79-81-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NO CREAMNO SSL
02 - H20 CC NO SSL
03 - DA CC NO SSL
04 - VEH CC NO SSL
05 - 0.1% RP NO SSL
06 - 0.25%RP NO SSL
07 - 0.5% RP NO SSL
08 - 1.0% RP NO SSL
09 - NO CREAM6.85 SSL
10 - H20 CC 6.85 SSL
11 - DA CC 6.85 SSL
12 - VEH CC 6.85 SSL
13 - 0.1% RP 6.85 SSL
14 - 0.25% RP6.85 SSL
15 - 0.5% RP 6.85 SSL
16 - 1.0% RP 6.85 SSL
17 - NO CREAM13.70SSL
18 - H20 CC 13.70SSL
19 - DA CC 13.70SSL
20 - VEH CC 13.70SSL
21 - 0.1% RP 13.70SSL
22 - 0.25% RP13.70SSL
23 - 0.5% RP 13.70SSL
24 - 1.0% RP 13.70SSL
25 - NO CREAM20.55SSL
26 - NO CREAMNO SSL
27 - H20 CC NO SSL
28 - DA CC NO SSL
29 - VEH CC NO SSL
30 - 0.1% RP NO SSL
31 - 0.25%RP NO SSL
32 - 0.5% RP NO SSL
33 - 1.0% RP NO SSL
34 - NO CREAM6.85 SSL
35 - H2O CC 6.85
36 - DA CC 6.85 SSL
37 - VEH CC 6.85
38 - 0.1% RP 6.85
39 - 0.25% RP6.85 SSL
40 - 0.5% RP 6.85 SSL
41 - 1.0% RP 6.85 SSL
42 - NO CREAM13.70SSL
43 - H2O CC 13.70SSL
44 - DA CC 13.70SSL
45 - VEH CC 13.70SSL
46 - 0.1% RP 13.70SSL
47 - 0.25% RP13.70SSL
48 - 0.5% RP 13.70SSL
49 - 1.0% RP 13.70SSL
50 - NO CREAM20.55SSL
U
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
U
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
NIH-41 (Irradiated)
Cosmetech Cream
Page 1344
NIH-41 (Irradiated)
Cosmetech Cream
NIH-41 (Irradiated)
Cosmetech Cream
NIH-41 (Irradiated)
Cosmetech Cream
NIH-41 (Irradiated)
Cosmetech Cream
NIH-41 (Irradiated)
Cosmetech Cream
NIH-41 (Irradiated)
All-trans-retinyl palmitate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
SKIN
20117-01
C20117
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SKH-1/NCTR
06/22/2003
NR
79-81-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
22 - NO CREAMNO SSL-M
23 - PH 7.0 NO SSL-M
24 - 2% RP NO SSL-M
25 - .001% RANO SSL-M
26 - NO CREAM6.85SSLM
27 - PH 7.0 6.85SSLM
28 - .1% RP 6.85SSLM
29 - .5% RP 6.85SSLM
30 - 1% RP 6.85SSLM
31 - 2% RP 6.85SSLM
32 - .001% RA6.85SSLM
33 - NO CREAM13.7SSLM
34 - PH 7.0 13.7SSLM
35 - .1% RP 13.7SSLM
36 - .5% RP 13.7SSLM
37 - 1% RP 13.7SSLM
38 - 2% RP 13.7SSLM
39 - .001% RA13.7SSLM
40 - NOCREAMM20.55SSL
41 - 1% RP NO SSL-M
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
NIH-31
Cosmetech Cream
Page 1345
NIH-31
Cosmetech Cream
NIH-31
Cosmetech Cream
NIH-31
Cosmetech Cream
All-trans-retinyl palmitate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
SKIN
20117-02
C20117
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, SKH-1/NCTR
06/22/2003
NR
79-81-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - NO CREAMNO SSL-F
02 - PH 7.0 NO SSL-F
03 - 2% RP NO SSL-F
04 - .001% RANO SSL-F
05 - NO CREAM6.85SSLF
06 - PH 7.0 6.85SSLF
07 - .1% RP 6.85SSLF
08 - .5% RP 6.85SSLF
09 - 1% RP 6.85SSLF
10 - 2% RP 6.85SSLF
11 - .001% RA6.85SSLF
12 - NO CREAM13.7SSLF
13 - PH 7.0 13.7SSLF
14 - .1% RP 13.7SSLF
15 - .5% RP 13.7SSLF
16 - 1% RP 13.7SSLF
17 - 2% RP 13.7SSLF
18 - .001% RA13.7SSLF
19 - NOCREAMF20.55SSL
20 - 1% RP NO SSL-F
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
NIH-31
Cosmetech Cream
Page 1346
NIH-31
Cosmetech Cream
NIH-31
Cosmetech Cream
NIH-31
Cosmetech Cream
Rhodamine 6G
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05048-01
C56122
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/25/1980
SO
989-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.025%
04 - 0.025%
05 - 0.012%
06 - 0.012%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1347
Rhodamine 6G (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05048-02
C56122
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/18/1980
SO
989-38-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.2%
04 - 0.1%
05 - 0.1%
06 - 0.05%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1348
Riddelliine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05161-03
C61358B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/18/1987
SR
23246-96-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - VEHICLE
03 - 0.10 MG/KG
04 - 0.10 MG/KG
05 - 0.33 MG/KG
06 - 0.33 MG/KG
07 - 1.00 MG/KG
08 - 1.00 MG/KG
09 - 3.3 MG/KG
10 - 3.3 MG/KG
11 - 10.0 MG/KG
12 - 10.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
WATER
Page 1349
Riddelliine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05161-04
C61358B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/11/1987
SR
23246-96-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE
02 - VEHICLE
03 - 0.33 MG/KG
04 - 0.33 MG/KG
05 - 1.00 MG/KG
06 - 1.00 MG/KG
07 - 3.30 MG/KG
08 - 3.30 MG/KG
09 - 10.0 MG/KG
10 - 10.00 MG/KG
11 - 25.00 MG/KG
12 - 25.00 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
WATER
Page 1350
Riddelliine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05161-05
C61358C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/06/1996
SO
23246-96-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 1.0 MG/KG/DY
03 - 0 MG/KG/DY
04 - 0.01 MG/KG/DY
05 - 0.033 MG/KG/DY
06 - 0.1 MG/KG/DY
07 - 0.33 MG/KG/DY
08 - 1.0 MG/KG/DY
V
T
V
T
T
T
T
T
M
M
F
F
F
F
F
F
WATER
Page 1351
Riddelliine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05161-06
C61358C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/20/1996
SO
23246-96-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG/DY
02 - 0 MG/KG/DY
03 - 0.1 MG/KG/DY
04 - 0.3 MG/KG/DY
05 - 1.0 MG/KG/DY
06 - 3.0 MG/KG/DY
07 - 3.0 MG/KG/DY
V
V
T
T
T
T
T
M
F
M
M
M
M
F
WATER
Page 1352
Riddelliine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05161-07
C61358C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/06/1996
SO
23246-96-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
09 - 0 MG/KG/DY
10 - 0.01 MG/KG/DY
11 - 0.033 MG/KG/DY
12 - 0.1 MG/KG/DY
13 - 0.33 MG/KG/DY
14 - 1.0 MG/KG/DY
V
T
T
T
T
T
F
F
F
F
F
F
WATER
Page 1353
Riddelliine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20328-02
C20328
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/04/2004
IL
23246-96-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 3HR
02 - .5 MG/KG3HR
03 - 1 MG/KG 3HR
04 - 5 MG/KG 3HR
05 - 0 MG/KG 6HR
06 - .5 MG/KG6HR
07 - 1 MG/KG6HR
08 - 5 MG/KG 6HR
09 - 0 MG/KG 24HR
10 - .5 MG/KG24HR
11 - 1 MG/KG 24HR
12 - 5 MG/KG 24HR
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
WATER
Page 1354
Roxarsone
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05058-01
C56508
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/17/1981
SO
121-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.01%
04 - 0.01%
05 - 0.005%
06 - 0.005%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1355
Roxarsone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05058-02
C56508
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/02/1981
SO
121-19-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD CONTROL
02 - UNTREATD CONTROL
03 - 0.02%
04 - 0.02%
05 - 0.01%
06 - 0.01%
U
U
T
T
T
T
M
F
M
F
M
F
NIH-07
Page 1356
Reprotox Universal Download
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
05050-15
C12345E
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
(NOT DEFINED)
HZ
C12345E
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F2b-Ctrl-Adult
02 - F2b-Ctrl-Adult
03 - F2b-Low-Adult
04 - F2b-Low-Adult
05 - F2b-Mid-Adult
06 - F2b-Mid-Adult
07 - F2b-High-Adult
08 - F2b-High-Adult
11 - F2bCtrl-Pup
12 - F2bCtrl-Pup
13 - F2b-Low-Pup
14 - F2b-Low-Pup
15 - F2b-Mid-Pup
16 - F2b-Mid-Pup
18 - F2b-High-Pup
V
V
T
T
T
T
T
T
V
V
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
F
CORN OIL
Page 1357
Safflower oil
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05144-01
C62204
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/07/1986
MA
8001-23-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ML/KG
02 - 2.5 ML/KG
03 - 5.0 MLK/KG
04 - 10.0 ML/KG
U
T
T
T
M
M
M
M
NIH-07
(UNSPECIFIED)
Page 1358
Salicylazosulfapyridine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05099-05
C61552
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/31/1986
MA
599-79-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 84.0 MG/KG
04 - 84.0 MG/KG
05 - 168.8 MG/KG
06 - 168.8 MG/KG
07 - 337.5 MG/KG
08 - 337.5 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1359
Salicylazosulfapyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05099-06
C61552
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/07/1986
MA
599-79-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG S
03 - 0 MG/KG
04 - 0 MG/KG S
05 - 675.0 MG/KG
06 - 675.0 MG/KG S
07 - 675.0 MG/KG
08 - 675.0 MG/KG S
09 - 1350.0 MG/KG
10 - 1350.0 MG/KG S
11 - 1350.0 MG/KG
12 - 1350.0 MG/KG S
13 - 2700.0 MG/KG
14 - 2700.0 MG/KG S
15 - 2700.0 MG/KG
16 - 2700.0 MG/KG S
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
CORN OIL
Page 1360
Salicylazosulfapyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05099-07
C61552B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/12/1988
SO
599-79-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 84 MG/KG
04 - 84 MG/KG
05 - 168 MG/KG
06 - 168 MG/KG
07 - 337.5 MG/KG
08 - 337.5 MG/KG
09 - 337.5 STOP
10 - 0 MG/KG FEED RTD
V
V
T
T
T
T
T
T
T
V
M
F
M
F
M
F
M
F
M
M
CORN OIL
Page 1361
Salicylazosulfapyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05099-08
C61552B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/03/1989
SO
599-79-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 675 MG/KG
04 - 675 MG/KG
05 - 1350 MG/KG
06 - 1350 MG/KG
07 - 2700 MG/KG
08 - 2700 MG/KG
09 - 0 MG/KG FEED RTD
V
V
T
T
T
T
T
T
V
M
F
M
F
M
F
M
F
M
CORN OIL
Page 1362
Salicylazosulfapyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC-LIFETIME
GAVAGE
05099-09
C61552B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/27/1988
SO
599-79-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 337.5_MG/KG RTD
V
T
M
M
CORN OIL
Page 1363
Salicylazosulfapyridine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC-LIFETIME
GAVAGE
05099-10
C61552B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/16/1989
SO
599-79-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 2700 MG/KG RTD
V
T
M
M
CORN OIL
Page 1364
Scopolamine hydrobromide trihydrate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05121-03
C03098A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/17/1986
SO
6533-68-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0 MG/KG
02 - 0.0 MG/KG
03 - 15.0 MG/KG
04 - 15.0 MG/KG
05 - 45.0 MG/KG
06 - 45.0 MG/KG
07 - 135.0 MG/KG
08 - 135.0 MG/KG
09 - 400.0 MG/KG
10 - 400.0 MG/KG
11 - 1200.0 MG/KG
12 - 1200.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1365
Scopolamine hydrobromide trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05121-04
C03098A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/21/1986
SO
6533-68-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 15 MG/KG
04 - 15 MG/KG
05 - 45 MG/KG
06 - 45 MG/KG
07 - 135 MG/KG
08 - 135 MG/KG
09 - 400 MG/KG
10 - 400 MG/KG
11 - 1200 MG/KG
12 - 1200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1366
Scopolamine hydrobromide trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05121-05
C03098C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/20/1988
BC
6533-68-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - O MG/KG
02 - O MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1367
Scopolamine hydrobromide trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05121-06
C03098C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/20/1988
BC
6533-68-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 1 MG/KG
04 - 1 MG/KG
05 - 5 MG/KG
06 - 5 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1368
Scopolamine hydrobromide trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05121-07
C03098C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/22/1988
BC
6533-68-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0 MG/KG FEED RTD
04 - 0 MG/KG FEED RTD
05 - 1 MG/KG
06 - 1 MG/KG
07 - 5 MG/KG
08 - 5 MG/KG
09 - 25 MG/KG
10 - 25 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1369
Scopolamine hydrobromide trihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05121-08
C03098C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/06/1988
BC
6533-68-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 104/WEEK
02 - 0 MG/KG 20%/36M
03 - 0 MG/KG 104/WEEK
04 - 0 MG/KG 20%/36M
05 - 25 MG/KG104/WEEK
06 - 25 MG/KG20%/36M
07 - 25 MG/KG104/WEEK
08 - 25 MG/KG20%/36M
V
V
V
V
T
T
T
T
F
F
M
M
F
F
M
M
DEIONIZED WATER
Page 1370
Senna (powdered)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
FEED
20101-01
C20101
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
10/12/2005
BC
8013-11-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 0 ppm
03 - 625 ppm
04 - 625 ppm
05 - 1250 ppm
06 - 1250 ppm
07 - 2500 ppm
08 - 2500 ppm
09 - 5000 ppm
10 - 5000 ppm
11 - 10,000 ppm
12 - 10,000 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1371
Senna (powdered) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
FEED
20101-02
C20101B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
06/25/2007
BC
8013-11-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 0 ppm
03 - 100 ppm
04 - 100 ppm
05 - 300 ppm
06 - 300 ppm
07 - 1000 ppm
08 - 1000 ppm
09 - 3000 ppm
10 - 3000 ppm
11 - 10,000 ppm
12 - 10,000 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1372
Serotype 5 Adeno-associated Viral Vector (rAAV5SCTLA4:Ig)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
08043-01
C08043
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
09/29/2008
MB
RAV5SCTLA4IG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Grp1 CohortA D3
02 - Grp2 CohortA D3
03 - Grp3 CohortA D3
04 - Grp4 CohortA D3
05 - Grp5 CohortA D3
06 - Grp1 CohrtB D29
07 - Grp2 CohrtB D29
08 - Grp3 CohrtB D29
09 - Grp4 CohrtB D29
10 - Grp5 CohrtB D29
11 - Grp1 CohrtC D57
12 - Grp2 CohrtC D57
13 - Grp3 CohrtC D57
14 - Grp4 CohrtC D57
15 - Grp5 CohrtC D57
16 - Grp1 CohrtD D92
17 - Grp2 CohrtD D92
18 - Grp3 CohrtD D92
19 - Grp4 CohrtD D92
20 - Grp5 CohrtD D92
21 - Grp1 CohortA D3
22 - Grp2 CohortA D3
23 - Grp3 CohortA D3
24 - Grp4 CohortA D3
25 - Grp5 CohortA D3
26 - Grp1 CohortB D29
27 - Grp2 CohortB D29
28 - Grp3 CohortB D29
29 - Grp4 CohortB D29
30 - Grp5 CohortB D29
31 - Grp1 CohortC D57
32 - Grp2 CohortC D57
33 - Grp3 CohortC D57
34 - Grp4 CohortC D57
35 - Grp5 CohortC D57
36 - Grp1 CohortD D92
37 - Grp2 CohortD D92
38 - Grp3 CohortD D92
39 - Grp4 CohortD D92
40 - Grp5 CohortD D92
V
T
T
T
T
V
V
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
SALINE
Page 1373
Serotype 5 Adeno-associated Viral Vector (rAAV5SCTLA4:Ig) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
08043-99
C08043
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
10/01/2008
MB
RAV5SCTLA4IG
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SS Gp6
02 - SS Gp7
03 - SS Gp6
04 - SS Gp7
V
T
V
T
M
M
F
F
SALINE
Page 1374
Serotype 2 Adeno-associated Viral Vector rAAV2rapahEpo
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
20722-01
C20722
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
11/26/2007
MB
AAVIRAAVHEPO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Grp1 CohortA D3
02 - Grp2 CohortA D3
03 - Grp3 CohortA D3
04 - Grp4 CohortA D3
05 - Grp5 CohortA D3
06 - Grp1 CohrtB D29
07 - Grp2 CohrtB D29
08 - Grp3 CohrtB D29
09 - Grp4 CohrtB D29
10 - Grp5 CohrtB D29
11 - Grp1 CohrtC D57
12 - Grp2 CohrtC D57
13 - Grp3 CohrtC D57
14 - Grp4 CohrtC D57
15 - Grp5 CohrtC D57
16 - Grp1 CohrtD D92
17 - Grp2 CohrtD D92
18 - Grp3 CohrtD D92
19 - Grp4 CohrtD D92
20 - Grp5 CohrtD D92
21 - Grp1 CohortA D3
22 - Grp2 CohortA D3
23 - Grp3 CohortA D3
24 - Grp4 CohortA D3
25 - Grp5 CohortA D3
26 - Grp1 CohortB D29
27 - Grp2 CohortB D29
28 - Grp3 CohortB D29
29 - Grp4 CohortB D29
30 - Grp5 CohortB D29
31 - Grp1 CohortC D57
32 - Grp2 CohortC D57
33 - Grp3 CohortC D57
34 - Grp4 CohortC D57
35 - Grp5 CohortC D57
36 - Grp1 CohortD D92
37 - Grp2 CohortD D92
38 - Grp3 CohortD D92
39 - Grp4 CohortD D92
40 - Grp5 CohortD D92
V
T
T
T
T
V
V
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
SALINE
Page 1375
Serotype 2 Adeno-associated Viral Vector rAAV2rapahEpo (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
20722-99
C20722
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
11/28/2007
MB
AAVIRAAVHEPO
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SS Gp6
02 - SS Gp7
03 - SS Gp6
04 - SS Gp7
V
T
V
T
M
M
F
F
SALINE
Page 1376
Serotype 2 Adeno-associated Viral Vector hAQP1 (rAAV2hAQP1)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
10336-01
C10336
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
04/11/2011
MB
AAV2HAQP1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Grp1 CohortA D3
02 - Grp2 CohortA D3
03 - Grp3 CohortA D3
04 - Grp4 CohortA D3
05 - Grp5 CohortA D3
06 - Grp1 CohrtB D29
07 - Grp2 CohrtB D29
08 - Grp3 CohrtB D29
09 - Grp4 CohrtB D29
10 - Grp5 CohrtB D29
11 - Grp1 CohrtC D57
12 - Grp2 CohrtC D57
13 - Grp3 CohrtC D57
14 - Grp4 CohrtC D57
15 - Grp5 CohrtC D57
16 - Grp1 CohrtD D92
17 - Grp2 CohrtD D92
18 - Grp3 CohrtD D92
19 - Grp4 CohrtD D92
20 - Grp5 CohrtD D92
21 - Grp1 CohortA D3
22 - Grp2 CohortA D3
23 - Grp3 CohortA D3
24 - Grp4 CohortA D3
25 - Grp5 CohortA D3
26 - Grp1 CohortB D29
27 - Grp2 CohortB D29
28 - Grp3 CohortB D29
29 - Grp4 CohortB D29
30 - Grp5 CohortB D29
31 - Grp1 CohortC D57
32 - Grp2 CohortC D57
33 - Grp3 CohortC D57
34 - Grp4 CohortC D57
35 - Grp5 CohortC D57
36 - Grp1 CohortD D92
37 - Grp2 CohortD D92
38 - Grp3 CohortD D92
39 - Grp4 CohortD D92
40 - Grp5 CohortD D92
V
T
T
T
T
V
V
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
F
SALINE
Page 1377
Serotype 2 Adeno-associated Viral Vector hAQP1 (rAAV2hAQP1) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
10336-99
C10336
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
04/13/2011
MB
AAV2HAQP1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - SS Gp6
02 - SS Gp7
03 - SS Gp6
04 - SS Gp7
V
T
V
T
M
M
F
F
SALINE
Page 1378
Sodium azide
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05026-01
C06462
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/07/1982
MB
26628-22-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG VEHICLEM
03 - 0 G/KG VEHICLEF
05 - 5 MG/KG LOW MALE
07 - 5 MG/KG LOW FEMA
09 - 10MG/KG HIGHMALE
11 - 10MG/KG HIGH FEM
V
V
T
T
T
T
M
F
M
F
M
F
WATER
Page 1379
Sodium cyanide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05159-05
C62124B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/07/1988
SO
143-33-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.0003%
04 - 0.0003%
05 - 0.001%
06 - 0.001%
07 - 0.003%
08 - 0.003%
09 - 0.01%
10 - 0.01%
11 - 0.03%
12 - 0.03%
13 - 0.0%
14 - 0.0003%
15 - 0.001%
16 - 0.003%
17 - 0.01%
18 - 0.03%
V
V
T
T
T
T
T
T
T
T
T
T
V
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
M
M
M
M
M
DEIONIZED WATER
Page 1380
Sodium cyanide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05159-06
C62124B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/19/1988
SO
143-33-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.0003%
04 - 0.0003%
05 - 0.001%
06 - 0.001%
07 - 0.003%
08 - 0.003%
09 - 0.01%
10 - 0.01%
11 - 0.03%
12 - 0.03%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1381
SODIUM DICHROMATE DIHYDRATE (VI)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
06249-01
C06249
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/26/2001
BC
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1000 PPM
04 - 1000 PPM
V
V
T
T
M
F
M
F
DEIONIZED WATER
Page 1382
SODIUM DICHROMATE DIHYDRATE (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
06249-02
C06249
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/26/2001
BC
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1000 PPM
04 - 1000 PPM
V
V
T
T
M
F
M
F
DEIONIZED WATER
Page 1383
Sodium dichromate dihydrate (VI)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20114-01
C20114
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/11/2001
SO
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5MG/L
04 - 62.5MG/L
05 - 125MG/L
06 - 125MG/L
07 - 250MG/L
08 - 250MG/L
09 - 500MG/L
10 - 500MG/L
11 - 1000 MG/L
12 - 1000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1384
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20114-02
C20114
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/13/2001
SO
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1385
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20114-03
C20114B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
08/22/2002
BC
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 62.5 MG/L
03 - 125 MG/L
04 - 250 MG/L
V
T
T
T
M
M
M
M
TAP WATER
Page 1386
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20114-04
C20114B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, AM3
08/23/2002
BC
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 62.5 MG/L
03 - 125 MG/L
04 - 250 MG/L
V
T
T
T
M
M
M
M
TAP WATER
Page 1387
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20114-05
C20114B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/20/2002
BC
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 62.5 MG/L
03 - 125 MG/L
04 - 250 MG/L
V
T
T
T
M
M
M
M
TAP WATER
Page 1388
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20114-06
C20114
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/04/2002
SO
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 14.3 MG/L
04 - 14.3 MG/L
05 - 28.6 MG/L
06 - 57.3 MG/L
07 - 85.7 MG/L
08 - 172 MG/L
09 - 257.4 MG/L
10 - 516 MG/L
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1389
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
20114-07
C20114
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/02/2002
SO
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 14.3 MG/L
04 - 14.3 MG/L
05 - 57.3 MG/L
06 - 57.3 MG/L
07 - 172 MG/L
08 - 172 MG/L
09 - 516 MG/L
10 - 516 MG/L
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1390
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
WATER
20114-97
C20114
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/04/2002
SO
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 14.3 MG/L
03 - 57.3 MG/L
04 - 172 MG/L
05 - 516 MG/L
U
T
T
T
T
M
M
M
M
M
TAP WATER
Page 1391
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
WATER
20114-98
C20114
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/13/2002
SO
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 14.3 MG/L
03 - 57.3 MG/L
04 - 172 MG/L
05 - 516 MG/L
U
T
T
T
T
F
F
F
F
F
TAP WATER
Page 1392
Sodium dichromate dihydrate (VI) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
20114-99
C20114B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, AM3
08/23/2002
BC
7789-12-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 62.5 MG/L
03 - 125 MG/L
04 - 250 MG/L
V
T
T
T
M
M
M
M
TAP WATER
Page 1393
Sodium Fluoride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05131-01
C55221B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/07/1985
BC
7681-49-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - SPECIAL CONTROL
04 - SPECIAL CONTROL
05 - 25 PPM
06 - 25 PPM
07 - 100 PPM
08 - 100 PPM
09 - 175 PPM
10 - 175 PPM
V
V
X
X
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1394
Sodium Fluoride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05131-02
C55221B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/28/1985
BC
7681-49-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - SPECIAL CONTROL
04 - SPECIAL CONTROL
05 - 25 PPM
06 - 25 PPM
07 - 100 PPM
08 - 100 PPM
09 - 175 PPM
10 - 175 PPM
V
V
X
X
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1395
SODIUM FLUORIDE
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
05131-03
C55221C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/26/1990
NE
7681-49-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 250 PPM
03 - IRRAD WATER
04 - 250 PPM IRR FL
V
T
T
T
M
M
M
M
DEIONIZED WATER
Page 1396
Sodium nitrite
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88007-01
C88007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/10/1989
MB
7632-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.0375%
04 - 0.0375%
05 - 0.075%
06 - 0.075%
07 - 0.15%
08 - 0.15%
09 - 0.3%
10 - 0.3%
11 - 0.5%
12 - 0.5%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1397
Sodium nitrite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88007-02
C88007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/07/1989
MB
7632-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.0375%
04 - 0.0375%
05 - 0.075%
06 - 0.075%
07 - 0.15%
08 - 0.15%
09 - 0.3%
10 - 0.3%
11 - 0.5%
12 - 0.5%
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1398
Sodium nitrite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
88007-03
C88007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/10/1989
MB
7632-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL SPECIAL
02 - CONTROL SPECIAL
03 - 0.0375% SPECIAL
04 - 0.0375% SPECIAL
05 - 0.075% SPECIAL
06 - 0.075% SPECIAL
07 - 0.15% SPECIAL
08 - 0.15% SPECIAL
09 - 0.3% SPECIAL
10 - 0.3% SPECIAL
11 - 0.5% SPECIAL
12 - 0.5% SPECIAL
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1399
Sodium nitrite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
88007-05
C88007B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/14/1995
BC
7632-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.075%
04 - 0.075%
05 - 0.15%
06 - 0.15%
07 - 0.30%
08 - 0.30%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1400
Sodium nitrite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
88007-06
C88007B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/02/1995
BC
7632-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.075%
04 - 0.075%
05 - 0.15%
06 - 0.15%
07 - 0.30%
08 - 0.30%
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1401
Sodium selenate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05195-03
C62113
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/25/1988
MA
13410-01-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3.75 PPM
04 - 3.75 PPM
05 - 7.5 PPM
06 - 7.5 PPM
07 - 15 PPM
08 - 15 PPM
09 - 30 PPM
10 - 30 PPM
11 - 60 PPM
12 - 60 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1402
Sodium selenate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05195-04
C62113
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/18/1988
MA
13410-01-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 3.75 PPM
04 - 3.75 PPM
05 - 7.5 PPM
06 - 7.5 PPM
07 - 15 PPM
08 - 15 PPM
09 - 30 PPM
10 - 30 PPM
11 - 60 PPM
12 - 60 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1403
Sodium selenite
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05196-03
C04308
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/16/1988
MA
10102-18-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2 PPM
04 - 2 PPM
05 - 4 PPM
06 - 4 PPM
07 - 8 PPM
08 - 8 PPM
09 - 16 PPM
10 - 16 PPM
11 - 32 PPM
12 - 32 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1404
Sodium selenite (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
05196-04
C04308
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/30/1988
MA
10102-18-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 2 PPM
04 - 2 PPM
05 - 4 PPM
06 - 4 PPM
07 - 8 PPM
08 - 8 PPM
09 - 16 PPM
10 - 16 PPM
11 - 32 PPM
12 - 32 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1405
Sodium thioglycolate
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
98007-01
C98007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/16/2001
MB
367-51-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 11.25 MG/KG
03 - 22.5 MG/KG
04 - 45 MG/KG
05 - 90 MG/KG
06 - 180 MG/KG
07 - VEHICLE CONTROL
08 - 11.25 MG/KG
09 - 22.5 MG/KG
10 - 45 MG/KG
11 - 90 MG/KG
12 - 180 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ETHANOL : WATER (1 : 1)
Page 1406
Sodium thioglycolate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
98007-02
C98007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/16/2001
MB
367-51-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 22.5 MG/KG
03 - 45 MG/KG
04 - 90 MG/KG
05 - 180 MG/KG
06 - 360 MG/KG
07 - VEHICLE CONTROL
08 - 22.5 MG/KG
09 - 45 MG/KG
10 - 90 MG/KG
11 - 180 MG/KG
12 - 360 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ETHANOL : WATER (1 : 1)
Page 1407
Sodium thioglycolate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
98007-03
C98007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/16/2002
MB
367-51-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 11.25 MG/KG
03 - 22.5 MG/KG
04 - 45.0 MG/KG
05 - 90.0 MG/KG
06 - 180.0 MG/KG
07 - VEHICLE CONTROL
08 - 11.25 MG/KG
09 - 22.5 MG/KG
10 - 45.0 MG/KG
11 - 90.0 MG/KG
12 - 180.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 1408
Sodium thioglycolate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
98007-04
C98007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/19/2002
MB
367-51-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 22.5 MG/KG
03 - 45.0 MG/KG
04 - 90.0 MG/KG
05 - 180.0 MG/KG
06 - 360.0 MG/KG
07 - VEHICLE CONTROL
08 - 22.5 MG/KG
09 - 45.0 MG/KG
10 - 90.0 MG/KG
11 - 180.0 MG/KG
12 - 360.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 1409
Sodium thioglycolate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
98007-99
C98007
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/16/2002
MB
367-51-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 11.25 MG/KG
03 - 22.5 MG/KG
04 - 45.0 MG/KG
05 - 90.0 MG/KG
06 - 180.0 MG/KG
07 - VEHICLE CONTROL
08 - 11.25 MG/KG
09 - 22.5 MG/KG
10 - 45.0 MG/KG
11 - 90.0 MG/KG
12 - 180.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AQUEOUS ETHANOL (95%)
Page 1410
Sodium Tungstate Dihydrate
TEST:
ROUTE:
TDMS #:
NTP #:
90 DAY W/PN EXP
WATER
03038-01
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/30/2009
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/L
02 - 0 mg/L
03 - 125 mg/L
04 - 125 mg/L
05 - 250 mg/L
06 - 250 mg/L
07 - 500 mg/L
08 - 500 mg/L
09 - 1000 mg/L
10 - 1000 mg/L
11 - 2000mg/L
12 - 2000 mg/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1411
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
WATER
03038-02
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
06/01/2009
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/L
02 - 0 mg/L
03 - 125 mg/L
04 - 125 mg/L
05 - 250 mg/L
06 - 250 mg/L
07 - 500 mg/L
08 - 500 mg/L
09 - 1000 mg/L
10 - 1000 mg/L
11 - 2000mg/L
12 - 2000 mg/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1412
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
03038-03
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/30/2012
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/L male
02 - 0mg/L female
03 - 250mg/L male
04 - 250mg/L female
05 - 500mg/L male
06 - 500mg/L female
07 - 1000mg/L male
08 - 1000mg/L female
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1413
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
03038-04
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
01/16/2012
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/L
02 - 0 mg/L
03 - 500 mg/L
04 - 500 mg/L
05 - 1000 mg/L
06 - 1000 mg/L
07 - 2000 mg/L
08 - 2000 mg/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1414
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
WATER
03038-89
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/30/2012
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/L male SS
02 - 0mg/L female SS
03 - 250mg/L male SS
04 - 250mg/L femaleSS
05 - 500mg/L male SS
06 - 500mg/L femaleSS
07 - 1000mg/L male SS
08 - 1000mg/LfemaleSS
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1415
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
WATER
03038-90
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
01/16/2012
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/L
02 - 0 mg/L
03 - 500 mg/L
04 - 500 mg/L
05 - 1000 mg/L
06 - 1000 mg/L
07 - 2000 mg/L
08 - 2000 mg/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1416
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
WATER
03038-95
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/09/2012
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/L Fpup
02 - 250mg/L Fpup
03 - 500mg/L Fpup
04 - 1000mg/L Fpup
V
T
T
T
F
F
F
F
DEIONIZED WATER
Page 1417
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
WATER
03038-96
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/09/2012
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/L malepup
02 - 250mg/L malepup
03 - 500mg/L malepup
04 - 1000mg/L malepup
V
T
T
T
M
M
M
M
DEIONIZED WATER
Page 1418
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
WATER
03038-97
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/09/2012
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/L DamLac
02 - 250mg/L DamLac
03 - 500mg/L DamLac
04 - 1000mg/L DamLac
V
T
T
T
F
F
F
F
DEIONIZED WATER
Page 1419
Sodium Tungstate Dihydrate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
WATER
03038-98
C03038
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
12/18/2011
BC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/L DamGes
02 - 250mg/L DamGes
03 - 500mg/L DamGes
04 - 1000mg/L DamGes
V
T
T
T
F
F
F
F
DEIONIZED WATER
Page 1420
Sodium xylenesulfonate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
05188-03
C55403C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/16/1988
SO
1300-72-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 5 MG/ML
04 - 5 MG/ML
05 - 15 MG/ML
06 - 15 MG/ML
07 - 44 MG/ML
08 - 44 MG/ML
09 - 133 MG/ML
10 - 133 MG/ML
11 - 400 MG/ML
12 - 400 MG/ML
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL : WATER (1 : 1)
Page 1421
Sodium xylenesulfonate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
05188-04
C55403C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/23/1988
SO
1300-72-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 5 MG/ML
04 - 5 MG/ML
05 - 15 MG/ML
06 - 15 MG/ML
07 - 44 MG/ML
08 - 44 MG/ML
09 - 133 MG/ML
10 - 133 MG/ML
11 - 400 MG/ML
12 - 400 MG/ML
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL : WATER (1 : 1)
Page 1422
Sodium xylenesulfonate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05188-05
C55403D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/29/1990
BC
1300-72-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 60 MG/KG
04 - 60 MG/KG
05 - 120 MG/KG
06 - 120 MG/KG
07 - 240 MG/KG
08 - 240 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ETHANOL : WATER (1 : 1)
Page 1423
Sodium xylenesulfonate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05188-06
C55403D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/20/1990
BC
1300-72-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 182 MG/KG
04 - 182 MG/KG
05 - 364 MG/KG
06 - 364 MG/KG
07 - 727 MG/KG
08 - 727 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ETHANOL : WATER (1 : 1)
Page 1424
Stoddard solvent (type lIC)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
96001-01
C96001
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/09/1997
BN
64742-88-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 138 MG/M3
04 - 138 MG/M3
05 - 275 MG/M3
06 - 275 MG/M3
07 - 550 MG/M3
08 - 550 MG/M3
09 - 1100 MG/M3
10 - 1100 MG/M3
11 - 2200 MG/M3
12 - 2200 MG/M3
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1425
Stoddard solvent (type lIC) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
96001-02
C96001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/09/1997
BN
64742-88-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 138 MG/M3
04 - 138 MG/M3
05 - 275 MG/M3
06 - 275 MG/M3
07 - 550 MG/M3
08 - 550 MG/M3
09 - 1100 MG/M3
10 - 1100 MG/M3
11 - 2200 MG/M3
12 - 2200 MG/M3
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1426
Stoddard solvent (type lIC) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
96001-03
C96001
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/09/1998
BN
64742-88-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 138 MG/M3
04 - 138 MG/M3
05 - 275 MG/M3
06 - 275 MG/M3
07 - 550 MG/M3
08 - 550 MG/M3
09 - 1100 MG/M3
10 - 1100 MG/M3
11 - 2200 MG/M3
12 - 2200 MG/M3
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1427
Stoddard solvent (type lIC) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
96001-04
C96001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/09/1998
BN
64742-88-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 138 MG/M3
04 - 138 MG/M3
05 - 275 MG/M3
06 - 275 MG/M3
07 - 550 MG/M3
08 - 550 MG/M3
09 - 1100 MG/M3
10 - 1100 MG/M3
11 - 2200 MG/M3
12 - 2200 MG/M3
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1428
Stoddard solvent (type lIC) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
96001-05
C96001
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/18/1999
BN
64742-88-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 138 MG/M3
04 - 550 MG/M3
05 - 550 MG/M3
06 - 1100 MG/M3
07 - 1100 MG/M3
08 - 2200 MG/M3
V
V
T
T
T
T
T
T
M
F
M
M
F
M
F
F
AIR
Page 1429
Stoddard solvent (type lIC) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
96001-06
C96001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/21/1998
BN
64742-88-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 550 MG/M3
04 - 550 MG/M3
05 - 1100 MG/M3
06 - 1100 MG/M3
07 - 2200 MG/M3
08 - 2200 MG/M3
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1430
Styrene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
02200-03
C02200B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/07/1990
BN
100-42-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 125 PPM
04 - 125 PPM
05 - 250 PPM
06 - 250 PPM
07 - 500 PPM
08 - 500 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 1500 PPM
12 - 1500 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1431
Styrene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
02200-04
C02200B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/06/1990
BN
100-42-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 62.5 PPM
04 - 62.5 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
09 - 500 PPM
10 - 500 PPM
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIR
Page 1432
Styrene-acrylonitrile trimer
TEST:
ROUTE:
TDMS #:
NTP #:
7-WEEK PERINATAL
FEED
99013-01
C99013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/08/2002
BC
SANTRIMER2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0_PPM DAMS
02 - 250_PPM DAMS
03 - 500_PPM DAMS
04 - 1000_PPM DAMS
05 - 2000_PPM DAMS
06 - 4000_PPM DAMS
V
T
T
T
T
T
F
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 1433
Styrene-acrylonitrile trimer (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
7-WEEK PERINATAL
FEED
99013-02
C99013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/19/2002
BC
SANTRIMER2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0_PPM PUPS
02 - 0 PPM PUPS
03 - 250 PPM PUPS
04 - 250 PPM PUPS
05 - 500 PPM PUPS
06 - 500 PPM PUPS
07 - 1000 PPM PUPS
08 - 1000 PPM PUPS
09 - 2000 PPM PUPS
10 - 2000 PPM PUPS
11 - 4000 PPM PUPS
12 - 4000 PPM PUPS
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1434
Styrene-acrylonitrile trimer (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-WEEK PN
FEED
99013-03
C99013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/17/2003
BC
SANTRIMER2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
09 - 800 PPM
10 - 800 PPM
11 - 1600 PPM
12 - 1600 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1435
Styrene-acrylonitrile trimer (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
FEED
99013-04
C99013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/29/2005
BC
SANTRIMER2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 400 PPM
03 - 800 PPM
04 - 1600 PPM
V
T
T
T
F
F
F
F
NIH-07 (IRRADIATED)
Page 1436
Styrene-acrylonitrile trimer (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
FEED
99013-05
C99013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/12/2005
BC
SANTRIMER2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 400 PPM
04 - 400 PPM
05 - 800 PPM
06 - 800 PPM
07 - 1600 PPM
08 - 1600 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1437
Styrene-acrylonitrile trimer (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
FEED
99013-99
C99013
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/12/2005
BC
SANTRIMER2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 400 PPM
04 - 400 PPM
05 - 800 PPM
06 - 800 PPM
07 - 1600 PPM
08 - 1600 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1438
Succinic anhydride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05041-01
C55696A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/30/1982
MB
108-30-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 50MG/KG LOW MALE
03 - 100MG/KGHIGHMALE
04 - CONTROL FEMALE
05 - 50 MG/KG LOW FEM
06 - 100MG/KG HIGHFEM
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1439
Skin Application Universal Download
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05050-09
C12345B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
(NOT DEFINED)
HZ
C12345B
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1440
Skin Application Universal Download (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05050-10
C12345B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(NOT DEFINED)
HZ
C12345B
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1441
Talc
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05079-01
C06008
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/02/1984
LI
14807-96-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 6 MG/M3
03 - 18 MG/M3
04 - CONTROL
05 - 6 MG/M3
06 - 18 MG/M3
07 - CONTROL LUNG TOX
08 - 6 MG/M3 LUNG TOX
09 - 18 MG/M3LUNG TOX
10 - CONTROL LUNG TOX
11 - 6 MG/M3 LUNG TOX
12 - 18 MG/M3LUNG TOX
V
T
T
V
T
T
V
T
T
V
T
T
M
M
M
F
F
F
M
M
M
F
F
F
UNTREATED
Page 1442
Talc (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05079-02
C06008
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/04/1984
LI
14807-96-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 6 MG/M3
03 - 18 MG/M3
04 - CONTOL
05 - 6 MG/M3
06 - 18 MG/M3
07 - CONTROL LUNG TOX
08 - 6 MG/M3 LUNG TOX
09 - 18 MG/M3LUNG TOX
10 - CONTROL LUNG TOX
11 - 6 MG/M3 LUNG TOX
12 - 18 MG/M3LUNG TOX
V
T
T
V
T
T
V
T
T
V
T
T
M
M
M
F
F
F
M
M
M
F
F
F
UNTREATED
Page 1443
Toxic equivalency factor evaluation (Binary mixture; PCB 126/PCB 153)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96020-01
C96020
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/16/1998
BC
TEFBINARYMIX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - BIN MIX GROUP 1
02 - BIN MIX GROUP 2
03 - BIN MIX GROUP 3
04 - BIN MIX GROUP 4
05 - BIN MIX GROUP 5
06 - BIN MIX GROUP 6
07 - BIN MIX GROUP 7
V
T
T
T
T
T
T
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1444
Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran))
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96007-05
C96007F
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
04/07/1999
BC
57117-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 6 NG/KG
03 - 20 NG/KG
04 - 44 NG/KG
05 - 92 NG/KG
06 - 200 NG/KG
07 - 200 NG/ KG STOP
V
T
T
T
T
T
T
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1445
Toxic equivalency factor evaluation (PCB 118)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20304-01
C20304
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
03/26/2004
BC
31508-00-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 10 UG/KG
03 - 30 UG/KG
04 - 100 UG/KG
05 - 220 UG/KG
06 - 460 UG/KG
07 - 1000 UG/KG
08 - 4600 UG/KG
09 - 4600 UG/KG STOP
V
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1446
Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96022-01
C96022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
03/09/1999
BC
TEFPCBMIX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 100 UG/KG
03 - 220 UG/KG
04 - 460 UG/KG
05 - 1000 UG/KG
06 - 4600 UG/KG
07 - 4600 UG/KG/STOP
V
T
T
T
T
T
T
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1447
Toxic equivalency factor evaluation (PCB Mixture; PCB 126/PCB 118) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96022-02
C96022
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/14/1999
BC
TEFPCBMIX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG TEQ/KG
02 - 7 NG TEQ/KG
03 - 22 NG TEQ/KG
04 - 72 NG TEQ/KG
05 - 216 NG TEQ/KG
06 - 360 NG TEQ/KG
07 - 360 NG TEQKG ST
V
T
T
T
T
T
T
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1448
Toxic equivalency factor evaluation (TCDD)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96007-03
C96007G
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/01/1998
BC
1746-01-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 3 NG/KG
03 - 10 NG/KG
04 - 22 NG/KG
05 - 46 NG/KG
06 - 100 NG/KG
07 - 100 NG/ KG/STOP
V
T
T
T
T
T
T
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1449
TEF transgenics (PCB 126)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
20201-02
C20201B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
04/21/2003
BC
57465-28-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 360 NG/KG
02 - 1210 NG/KG
03 - 3600 NG/KG
04 - 7600 NG/KG
T
T
T
T
F
F
F
F
ACETONE
Page 1450
TEF transgenics (PCB 126 / PECDF mixture)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
20201-04
C20201D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
04/21/2003
BC
TEFTGMIXTURE
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 36/180 NG/KG
02 - 121/605 NG/KG
03 - 360/1800NG/KG
04 - 760/3800NG/KG
T
T
T
T
F
F
F
F
ACETONE
Page 1451
TEF transgenics (PECDF)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
20201-03
C20201C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
04/21/2003
BC
57117-31-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 72 NG/KG
02 - 242 NG/KG
03 - 720 NG/KG
04 - 1520 NG/KG
T
T
T
T
F
F
F
F
ACETONE
Page 1452
TEF transgenics (TCDD)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
20201-01
C20201A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
04/21/2003
BC
1746-01-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 121 NG/KG
03 - 760 NG/KG
04 - TPA
V
T
T
P
F
F
F
F
ACETONE
Page 1453
Tetrabromobisphenol A
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20320-01
C20320
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
12/12/2005
BC
79-94-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 10 mg/kg
04 - 10 mg/kg
05 - 50 mg/kg
06 - 50 mg/kg
07 - 100 mg/kg
08 - 100 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1454
Tetrabromobisphenol A (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20320-02
C20320
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
12/14/2005
BC
79-94-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 10 mg/kg
04 - 10 mg/kg
05 - 50 mg/kg
06 - 50 mg/kg
07 - 100 mg/kg
08 - 100 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1455
Tetrabromobisphenol A (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20320-03
C20320
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Wistar Han
07/25/2007
BC
79-94-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 250 mg/kg
04 - 250 mg/kg
05 - 500 mg/kg
06 - 500 mg/kg
07 - 1000 mg/kg
08 - 1000 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1456
Tetrabromobisphenol A (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
20320-04
C20320
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/06/2007
BC
79-94-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 250 mg/kg
04 - 250 mg/kg
05 - 500 mg/kg
06 - 500 mg/kg
07 - 1000 mg/kg
08 - 1000 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1457
Tetrabromobisphenol A (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20320-99
C20320
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
12/12/2005
BC
79-94-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 10 mg/kg
04 - 10 mg/kg
05 - 50 mg/kg
06 - 50 mg/kg
07 - 100 mg/kg
08 - 100 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1458
Tetrabromobisphenol A-bis(2,3-dibromopropyl ether)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20321-01
C20321
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
01/09/2006
BC
21850-44-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1459
Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20321-02
C20321
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/11/2006
BC
21850-44-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 125 mg/kg
04 - 125 mg/kg
05 - 250 mg.kg
06 - 250 mg/kg
07 - 500 mg/kg
08 - 500 mg/kg
09 - 1000 mg/kg
10 - 1000 mg/kg
11 - 2000 mg/kg
12 - 2000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1460
Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
20321-99
C20321
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
01/09/2006
BC
21850-44-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1461
2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47)
TEST:
ROUTE:
TDMS #:
NTP #:
GD6-PND21
GAVAGE
20208-01
C20208
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
08/17/2006
BC
5436-43-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 25 mg/kg
03 - 50 mg/kg
04 - 100 mg/kg
05 - 200 mg/kg
V
T
T
T
T
F
F
F
F
F
CORN OIL
Page 1462
2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
GD6-PND21
GAVAGE
20208-02
C20208
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
09/06/2006
BC
5436-43-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 25 mg/kg
03 - 50 mg/kg
04 - 100 mg/kg
05 - 200 mg/kg
V
T
T
T
T
F
F
F
F
F
CORN OIL
Page 1463
2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
GD6-PND21
GAVAGE
20208-03
C20208
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG/Rash2/CB6F1
09/17/2006
BC
5436-43-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 25 mg/kg
03 - 50 mg/kg
04 - 100 mg/kg
05 - 200 mg/kg
V
T
T
T
T
M
M
M
M
M
CORN OIL
Page 1464
2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
GD6-PND21
GAVAGE
20208-04
C20208
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG/Rash2/CB6F1
09/17/2006
BC
5436-43-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 25 mg/kg
03 - 50 mg/kg
04 - 100 mg/kg
05 - 200 mg/kg
V
T
T
T
T
F
F
F
F
F
CORN OIL
Page 1465
3,3',4,4'-Tetrachloroazobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
17-DAY
GAVAGE
29323-01
C29323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
10/13/2006
TI
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 1.0 mg/kg
04 - 1.0 mg/kg
05 - 3.0 mg/kg
06 - 3.0 mg/kg
07 - 10 mg/kg
08 - 10 mg/kg
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1466
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
5-WEEK
GAVAGE
29323-02
C29323
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
09/29/2006
TI
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 1.0 mg/kg
03 - 3.0 mg/kg
04 - 10 mg/kg
V
T
T
T
F
F
F
F
CORN OIL
Page 1467
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88148-01
C88148
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/12/1992
MB
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 12.5 MG/KG
03 - 32 MG/KG
04 - 80 MG/KG
05 - 200 MG/KG
06 - 500 MG/KG
07 - 0 MG/KG
08 - 12.5 MG/KG
09 - 32 MG/KG
10 - 80 MG/KG
11 - 200 MG/KG
12 - 500 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1468
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88148-02
C88148
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/13/1992
MB
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 1 MG/KG
03 - 3.2 MG/KG
04 - 10 MG/KG
05 - 32 MG/KG
06 - 100 MG/KG
07 - 0 MG/KG
08 - 1 MG/KG
09 - 3.2 MG/KG
10 - 10 MG/KG
11 - 32 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1469
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88148-03
C88148
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/19/1993
MB
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.1MG/KG
03 - 1 MG/KG
04 - 3 MG/KG
05 - 10 MG/KG
06 - 30 MG/KG
07 - 0 MG/KG
08 - 0.1MG/KG
09 - 1 MG/KG
10 - 3 MG/KG
11 - 10 MG/KG
12 - 30 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1470
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88148-04
C88148
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/21/1993
MB
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.1MG/KG
03 - 1 MG/KG
04 - 3 MG/KG
05 - 10 MG/KG
06 - 30 MG/KG
07 - 0 MG/KG
08 - 0.1MG/KG
09 - 1 MG/KG
10 - 3 MG/KG
11 - 10 MG/KG
12 - 30 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1471
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88148-05
C88148B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
12/14/2000
BC
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.1 MG/KG
04 - 0.1 MG/KG
05 - 0.3 MG/KG
06 - 0.3 MG/KG
07 - 1.0 MG/KG
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 3.0 MG/KG
11 - 10.0 MG/KG
12 - 10.0 MG/KG
13 - 30.0 MG/KG
14 - 30.0 MG/KG
15 - 100.00 MG/KG
16 - 100.0 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL : ACETONE (99 : 1)
Page 1472
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88148-06
C88148C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/29/2003
BC
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 10 MG/KG
04 - 10 MG/KG
05 - 30 MG/KG
06 - 30 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL : ACETONE (99 : 1)
Page 1473
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
88148-07
C88148C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/03/2003
BC
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 10 MG/KG
06 - 10 MG/KG
07 - 30 MG/KG
08 - 30 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL : ACETONE (99 : 1)
Page 1474
3,3',4,4'-Tetrachloroazobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88148-99
C88148B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
12/18/2000
BC
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.1 MG/KG
03 - 3.0 MG/KG
04 - 100.0 MG/KG
V
T
T
T
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1475
3,3',4,4'-Tetrachloroazoxybenzene
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88149-01
C88149
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/19/1992
MB
21232-47-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 12.5 MG/KG
03 - 32 MG/KG
04 - 80 MG/KG
05 - 200 MG/KG
06 - 500 MG/KG
07 - 0 MG/KG
08 - 12.5 MG/KG
09 - 32 MG/KG
10 - 80 MG/KG
11 - 200 MG/KG
12 - 500 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1476
3,3',4,4'-Tetrachloroazoxybenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
88149-02
C88149
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/20/1992
MB
21232-47-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 1 MG/KG
03 - 3.2 MG/KG
04 - 10 MG/KG
05 - 32 MG/KG
06 - 100 MG/KG
07 - 0 MG/KG
08 - 1 MG/KG
09 - 3.2 MG/KG
10 - 10 MG/KG
11 - 32 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1477
3,3',4,4'-Tetrachloroazoxybenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88149-03
C88149
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/12/1993
MB
21232-47-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.1MG/KG
03 - 1 MG/KG
04 - 3 MG/KG
05 - 10 MG/KG
06 - 30 MG/KG
07 - 0 MG/KG
08 - 0.1MG/KG
09 - 1 MG/KG
10 - 3 MG/KG
11 - 10 MG/KG
12 - 30 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1478
3,3',4,4'-Tetrachloroazoxybenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
88149-04
C88149
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/14/1993
MB
21232-47-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.1MG/KG
03 - 1 MG/KG
04 - 3 MG/KG
05 - 10 MG/KG
06 - 30 MG/KG
07 - 0 MG/KG
08 - 0.1MG/KG
09 - 1 MG/KG
10 - 3 MG/KG
11 - 10 MG/KG
12 - 30 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1479
1,2,4,5-Tetrachlorobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05164-03
C61949
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/30/1987
MB
95-94-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 0 PPM SPECIAL
04 - 0 PPM SPECIAL
05 - 30 PPM
06 - 30 PPM
07 - 30 PPM SPECIAL
08 - 30 PPM SPECIAL
09 - 100 PPM
10 - 100 PPM
11 - 100 PPM SPECIAL
12 - 100 PPM SPECIAL
13 - 300 PPM
14 - 300 PPM
15 - 300 PPM SPECIAL
16 - 300 PPM SPECIAL
17 - 1000 PPM
18 - 1000 PPM
19 - 1000 PPM SPECIAL
20 - 1000 PPM SPECIAL
21 - 2000 PPM
22 - 2000 PPM
23 - 2000 PPM SPECIAL
24 - 2000 PPM SPECIAL
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL, NIH-07
Page 1480
1,2,4,5-Tetrachlorobenzene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05164-04
C61949
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/31/1987
MB
95-94-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 30 PPM
04 - 30 PPM
05 - 100 PPM
06 - 100 PPM
07 - 300 PPM
08 - 300 PPM
09 - 1000 PPM
10 - 1000 PPM
11 - 2000 PPM
12 - 2000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL, NIH-07
Page 1481
1,1,2,2-Tetrachloroethane
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
03554-11
C03554E
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/03/1993
MB
79-34-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - VEHICLE CONTROL
03 - 18 MG/KG
04 - 37 MG/KG
05 - 75 MG/KG
06 - 150 MG/KG
07 - 300 MG/KG
08 - UNTREAT CONTROL
09 - VEHICLE CONTROL
10 - 18 MG/KG
11 - 37 MG/KG
12 - 75 MG/KG
13 - 150 MG/KG
14 - 300 MG/KG
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NIH-07
MICROCAPSULES, NIH-07
Page 1482
NIH-07
MICROCAPSULES, NIH-07
1,1,2,2-Tetrachloroethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
03554-12
C03554E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/01/1993
MB
79-34-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - VEHICLE CONTROL
03 - 88 MG/KG
04 - 175 MG/KG
05 - 350 MG/KG
06 - 700 MG/KG
07 - 1400 MG/KG
08 - UNTREAT CONTROL
09 - VEHICLE CONTROL
10 - 88 MG/KG
11 - 175 MG/KG
12 - 350 MG/KG
13 - 700 MG/KG
14 - 1400 MG/KG
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NIH-07
MICROCAPSULES, NIH-07
Page 1483
NIH-07
MICROCAPSULES, NIH-07
Tetrachlorophthalic anhydride
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05113-01
C61585
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/03/1987
MA
117-08-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 94 MG/KG
04 - 94 MG/KG
05 - 187 MG/KG
06 - 187 MG/KG
07 - 375 MG/KG
08 - 375 MG/KG
09 - 750 MG/KG
10 - 750 MG/KG
11 - 1500 MG/KG
12 - 1500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1484
Tetrachlorophthalic anhydride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05113-02
C61585
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/26/1987
MA
117-08-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 94 MG/KG
04 - 94 MG/KG
05 - 187 MG/KG
06 - 187 MG/KG
07 - 375 MG/KG
08 - 375 MG/KG
09 - 750 MG/KG
10 - 750 MG/KG
11 - 1500 MG/KG
12 - 1500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1485
Tetrafluoroethylene
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05132-03
C61596
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/25/1986
BN
116-14-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
09 - 2500 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1486
Tetrafluoroethylene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05132-04
C61596
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/27/1986
BN
116-14-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
09 - 2500 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1487
Tetrafluoroethylene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05132-05
C61596B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/23/1988
BN
116-14-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 156 PPM
04 - 312 PPM
05 - 312 PPM
06 - 625 PPM
07 - 625 PPM
08 - 1250 PPM
V
V
T
T
T
T
T
T
M
F
M
M
F
M
F
F
AIR
Page 1488
Tetrafluoroethylene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05132-06
C61596B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/09/1988
BN
116-14-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 312 PPM
04 - 312 PPM
05 - 625 PPM
06 - 625 PPM
07 - 1250 PPM
08 - 1250 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1489
1-trans-delta-9-Tetrahydrocannabinol
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05214-01
C56371B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/13/1988
MA
1972-08-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1490
1-trans-delta-9-Tetrahydrocannabinol (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05214-02
C56371B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/11/1988
MA
1972-08-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 125 MG/KG
04 - 125 MG/KG
05 - 250 MG/KG
06 - 250 MG/KG
07 - 500 MG/KG
08 - 500 MG/KG
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1491
Tetrahydrofuran
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05181-01
C60560B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/10/1987
BN
109-99-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 66 PPM
04 - 66 PPM
05 - 200 PPM
06 - 200 PPM
07 - 600 PPM
08 - 600 PPM
09 - 1800 PPM
10 - 1800 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1492
Tetrahydrofuran (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
05181-02
C60560B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/12/1987
BN
109-99-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 66 PPM
04 - 66 PPM
05 - 200 PPM
06 - 200 PPM
07 - 600 PPM
08 - 600 PPM
09 - 1800 PPM
10 - 1800 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1493
Tetrahydrofuran (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05181-03
C60560C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/14/1989
BN
109-99-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 200 PPM
04 - 200 PPM
05 - 600 PPM
06 - 600 PPM
07 - 1800 PPM
08 - 1800 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1494
Tetrahydrofuran (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05181-04
C60560C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/07/1989
BN
109-99-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 200 PPM
04 - 200 PPM
05 - 600 PPM
06 - 600 PPM
07 - 1800 PPM
08 - 1800 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1495
Tetralin
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
93025-01
C93025
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/07/1996
BN
119-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 7.5 PPM
04 - 7.5 PPM
05 - 15 PPM
06 - 15 PPM
07 - 30 PPM
08 - 30 PPM
09 - 60 PPM
10 - 60 PPM
11 - 120 PPM
12 - 120 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1496
Tetralin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
93025-02
C93025
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/07/1996
BN
119-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 7.5 PPM
04 - 7.5 PPM
05 - 15 PPM
06 - 15 PPM
07 - 30 PPM
08 - 30 PPM
09 - 60 PPM
10 - 60 PPM
11 - 120 PPM
12 - 120 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1497
Tetralin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
93025-03
C93025
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, NCI BLK RTR
04/07/1996
BN
119-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 7.5 PPM
03 - 15 PPM
04 - 30 PPM
05 - 60 PPM
06 - 120 PPM
U
T
T
T
T
T
M
M
M
M
M
M
AIR
Page 1498
Tetralin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
93025-04
C93025
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/19/1996
BN
119-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 7.5 PPM
04 - 7.5 PPM
05 - 15 PPM
06 - 15 PPM
07 - 30 PPM
08 - 30 PPM
09 - 60 PPM
10 - 60 PPM
11 - 120 PPM
12 - 120 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1499
Tetralin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
93025-05
C93025
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/19/1996
BN
119-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 7.5 PPM
04 - 7.5 PPM
05 - 15 PPM
06 - 15 PPM
07 - 30 PPM
08 - 30 PPM
09 - 60 PPM
10 - 60 PPM
11 - 120 PPM
12 - 120 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1500
Tetralin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
93025-06
C93025
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/23/2003
BN
119-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 30 PPM
04 - 30 PPM
05 - 60 PPM
06 - 60 PPM
07 - 120 PPM
08 - 120 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1501
Tetralin (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
93025-07
C93025
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/16/2003
BN
119-64-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 30 PPM
04 - 30 PPM
05 - 60 PPM
06 - 60 PPM
07 - 120 PPM
08 - 120 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1502
Tetranitromethane
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05072-01
C55947
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/24/1982
MW
509-14-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 5 PPM
03 - 2 PPM
04 - CONTROL
05 - 5 PPM
06 - 2 PPM
U
T
T
U
T
T
F
F
F
M
M
M
AIR
Page 1503
Tetranitromethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05072-02
C55947
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/12/1982
MW
509-14-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 2 PPM
03 - 0.5 PPM
04 - CONTROL
05 - 2 PPM
06 - 0.5 PPM
U
T
T
U
T
T
F
F
F
M
M
M
AIR
Page 1504
Theophylline
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05067-03
C61609A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/14/1986
SO
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 37.5 MG/KG
04 - 37.5 MG/KG
05 - 75.0 MG/KG
06 - 75.0 MG/KG
07 - 150.0 MG/KG
08 - 150.0 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1505
Theophylline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05067-04
C61609A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/18/1986
SO
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 75 MG/KG
04 - 75 MG/KG
05 - 150 MG/KG
06 - 150 MG/KG
07 - 300 MG/KG
08 - 300 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1506
Theophylline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05067-05
C61609B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/31/1986
SO
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1000 PPM
04 - 1000 PPM
05 - 2000 PPM
06 - 2000 PPM
07 - 4000 PPM
08 - 4000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1507
Theophylline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05067-06
C61609B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/04/1986
SO
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1000 PPM
04 - 1000 PPM
05 - 2000 PPM
06 - 2000 PPM
07 - 4000 PPM
08 - 4000 PPM
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1508
Theophylline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05067-07
C61609C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/05/1989
MB
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 7.5 MG/KG
03 - 25 MG/KG
04 - 75 MG/KG
05 - 0 MG/KG
06 - 7.5 MG/KG
07 - 25 MG/KG
08 - 75 MG/KG
11 - 0 MG/KG SPECIAL
12 - 7.5MG/KGSPECIAL
13 - 25 MG/KGSPECIAL
14 - 75 MG/KGSPECIAL
15 - 0_MG/KG SPECIAL
16 - 7.5MG/KGSPECIAL
17 - 25 MG/KGSPECIAL
18 - 75 MG/KGSPECIAL
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
CORN OIL
Page 1509
Theophylline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05067-08
C61609C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/07/1989
MB
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 15 MG/KG
03 - 50 MG/KG
04 - 150 MG/KG
05 - 0 MG/KG
06 - 7.5 MG/KG
07 - 25 MG/KG
08 - 75 MG/KG
11 - 0 MG/KG
12 - 15 MG/KGSPECIAL
13 - 50 MG/KGSPECIAL
14 - 150MG/KGSPECIAL
15 - 0 MG/KG SPECIAL
16 - 7.5MG/KGSPECIAL
17 - 25 MG/KGSPECIAL
18 - 75 MG/KGSPECIAL
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
CORN OIL
Page 1510
Theophylline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05067-09
C61609D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/25/1990
SO
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 7.5 MG/KG
04 - 7.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 75 MG/KG
08 - 75 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1511
Theophylline (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05067-10
C61609D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/15/1990
SO
58-55-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - 15 MG/KG
04 - 7.5 MG/KG
05 - 50 MG/KG
06 - 25 MG/KG
07 - 150 MG/KG
08 - 75 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1512
Thioacetamide
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20415-01
C20415
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/30/2004
IL
62-55-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG 6 HR
02 - 15 MG/KG 6 HR
03 - 50 MG/KG 6 HR
04 - 150 MG/KG 6 HR
05 - 0 MG/KG 24 HR
06 - 15 MG/KG 24 HR
07 - 50 MG/KG 24 HR
08 - 150 MG/KG 24 HR
09 - 0 MG/KG 48 HR
10 - 15 MG/KG 48 HR
11 - 50 MG/KG 48 HR
12 - 150 MG/KG 48 HR
V
T
T
T
V
V
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
PHOSPHATE BUFFERED SALINE
Page 1513
4,4-Thiobis(6-tert-butyl-m-cresol)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05065-01
C61610A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/01/1984
BS
96-69-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.025%
04 - 0.025%
05 - 0.05%
06 - 0.05%
07 - 0.10%
08 - 0.10%
09 - 0.25%
10 - 0.25%
11 - 0.50%
12 - 0.50%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1514
4,4-Thiobis(6-tert-butyl-m-cresol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05065-02
C61610A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/08/1984
BS
96-69-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0%
02 - 0%
03 - 0.01%
04 - 0.01%
05 - 0.25%
06 - 0.25%
07 - 0.05%
08 - 0.05%
09 - 0.10%
10 - 0.10%
11 - 0.25%
12 - 0.25%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1515
4,4-Thiobis(6-tert-butyl-m-cresol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05165-01
C61610B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/22/1986
BC
96-69-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM 65 PATH
03 - 0 PPM
04 - 0 PPM 65 PATH
05 - 500 PPM
06 - 500 PPM 65 PATH
07 - 500 PPM
08 - 500 PPM 65 PATH
09 - 1000 PPM
10 - 1000 PPM 65 PATH
11 - 1000 PPM
12 - 1000 PPM 65 PATH
13 - 2500 PPM
14 - 2500 PPM 65 PATH
15 - 2500 PPM
16 - 2500 PPM 65 PATH
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
M
M
F
F
M
M
F
F
M
M
F
F
M
M
F
F
NIH-07
Page 1516
4,4-Thiobis(6-tert-butyl-m-cresol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05165-02
C61610B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/19/1987
BC
96-69-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 250 PPM
04 - 250 PPM
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1517
4,4-Thiobis(6-tert-butyl-m-cresol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05165-03
C61610B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/29/1986
BC
96-69-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM NEURO
02 - 0 PPM HCU
03 - 0 PPM HCU
04 - 500 PPM NEURO
05 - 500 PPM HCU
06 - 500 PPM HCU
07 - 1000 PPM NEURO
08 - 1000 PPM HCU
09 - 1000 PPM HCU
10 - 2500 PPM NEURO
11 - 2500 PPM HCU
12 - 2500 PPM HCU
V
V
V
T
T
T
T
T
T
T
T
T
M
M
F
M
M
F
M
M
F
M
M
F
NIH-07
Page 1518
4,4-Thiobis(6-tert-butyl-m-cresol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05165-04
C61610B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/19/1987
BC
96-69-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM HCU
02 - 0 PPM HCU
03 - 250 PPM HCU
04 - 250 PPM HCU
05 - 500 PPM HCU
06 - 500 PPM HCU
07 - 1000 PPM HCU
08 - 1000 PPM HCU
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1519
alpha-Thujone
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99021-01
C99021
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/23/2001
MB
546-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1520
alpha-Thujone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99021-02
C99021
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/23/2001
MB
546-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1521
alpha-Thujone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99021-96
C99021
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/25/2001
MB
546-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1522
alpha-Thujone (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99021-97
C99021
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/01/2001
MB
546-80-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1523
alpha/beta Thujone mixture
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99037-01
C99037
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/07/2001
MB
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1524
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99037-02
C99037
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/07/2001
MB
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1525
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99037-03
C99037B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/12/2002
SO
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 100 MG/KG
12 - 100 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1526
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99037-04
C99037B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/14/2002
SO
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6.25 MG/KG
04 - 6.25 MG/KG
05 - 12.5 MG/KG
06 - 12.5 MG/KG
07 - 25 MG/KG
08 - 25 MG/KG
09 - 50 MG/KG
10 - 50 MG/KG
11 - 75 MG/KG
12 - 75 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1527
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99037-05
C99037B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/09/2003
SO
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1528
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99037-06
C99037B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/30/2003
SO
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 6 MG/KG
06 - 6 MG/KG
07 - 12 MG/KG
08 - 12 MG/KG
09 - 25 MG/KG
10 - 25 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1529
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99037-96
C99037
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/09/2001
MB
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1530
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
99037-97
C99037
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/15/2001
MB
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 3.0 MG/KG
04 - 10.0 MG/KG
05 - 30.0 MG/KG
06 - 100 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 3.0 MG/KG
10 - 10.0 MG/KG
11 - 30.0 MG/KG
12 - 100 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1531
alpha/beta Thujone mixture (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
GAVAGE
99037-98
C99037B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/12/2002
SO
76231-76-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 75 MG/KG
10 - 75 MG/KG
11 - 100 MG/KG
12 - 100 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1532
Titanocene dichloride
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05047-01
C04502
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/14/1983
MA
1271-19-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE 79VM
02 - 0.025 G/KG 79 LM
03 - 0.05 G/KG 79 HM
04 - VEHICLE 79 VF
05 - 0.025 G/KG 79 LF
06 - 0.05 G/KG 79 HF
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1533
D-alpha-Tocopheryl acetate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05071-01
C61370
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
01/09/1984
MB
58-95-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - VEHICLE CONTROL
03 - .125 G/KG
04 - .250 G/KG
05 - .500 G/KG
06 - 1.0 G/KG
07 - 2.0 G/KG
08 - UNTREAT CONTROL
09 - VEHICLE CONTROL
10 - .125 G/KG
11 - .250 G/KG
12 - .500 G/KG
13 - 1.0 G/KG
14 - 2.0 G/KG
U
V
T
T
T
T
T
U
V
T
T
T
T
T
M
M
M
M
M
M
M
F
F
F
F
F
F
F
AIN-76A
CORN OIL
Page 1534
AIN-76A
CORN OIL
D-alpha-Tocopheryl acetate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
05071-02
C61370
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/07/1984
MB
58-95-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - VEHICLE CONTROL
03 - .125 G/KG
04 - .500 G/KG
05 - 2.0 G/KG
06 - UNTREAT CONTROL
07 - VEHICLE CONTROL
08 - .125 G/KG
09 - .500 G/KG
10 - 2.0 G/KG
U
V
T
T
T
U
V
T
T
T
M
M
M
M
M
F
F
F
F
F
NIH-07
CORN OIL
Page 1535
NIH-07
CORN OIL
Toluene
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05701-01
C07272B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/04/1982
IR
108-88-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREAT CONTROL
02 - MEDIUM DOSE
03 - HIGH DOSE
04 - LOW DOSE
05 - UNTREAT CONTROL
06 - MEDIUM DOSE
07 - HIGH DOSE
08 - LOW DOSE
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
AIR
(UNSPECIFIED)
Page 1536
AIR
(UNSPECIFIED)
Toluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05701-02
C07272B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/27/1982
IR
108-88-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 600 PPM
03 - 1200 PPM
04 - 0 PPM
05 - 600 PPM
06 - 1200 PPM
U
T
T
U
T
T
M
M
M
F
F
F
AIR
Page 1537
Toluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05701-03
C07272B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/08/1982
IR
108-88-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 600 PPM
03 - 1200 PPM
04 - 120 PPM
05 - 0 PPM
06 - 600 PPM
07 - 1200 PPM
08 - 120 PPM
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
AIR
Page 1538
p-Toluenesulfonamide
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
20301-01
C20301
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
07/05/2006
MB
70-55-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 750 PPM
03 - 1500 PPM
04 - 3000 PPM
05 - 10000 PPM
06 - 30000 PPM
07 - VEHICLE CONTROL
08 - 750 PPM
09 - 1500 PPM
10 - 3000 PPM
11 - 10000 PPM
12 - 30000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NTP 2000 (IRRADIATED)
Page 1539
p-Toluenesulfonamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
FEED
20301-02
C20301
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
07/06/2006
MB
70-55-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 750 PPM
03 - 1500 PPM
04 - 3000 PPM
05 - 10000 PPM
06 - 30000 PPM
07 - VEHICLE CONTROL
08 - 750 PPM
09 - 1500 PPM
10 - 3000 PPM
11 - 10000 PPM
12 - 30000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NTP 2000 (IRRADIATED)
Page 1540
p-Toluenesulfonamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20301-03
C20301
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
10/17/2006
MB
70-55-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 625 PPM
03 - 1250 PPM
04 - 2500 PPM
05 - 5000 PPM
06 - 10000 PPM
07 - 0 PPM
08 - 625 PPM
09 - 1250 PPM
10 - 2500 PPM
11 - 5000 PPM
12 - 10000 PPM
13 - 0 PPM
14 - 625 PPM
15 - 1250 PPM
16 - 2500 PPM
17 - 5000 PPM
18 - 10000 PPM
19 - 0 PPM
20 - 625 PPM
21 - 1250 PPM
22 - 2500 PPM
23 - 5000 PPM
24 - 10000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
M
M
M
M
M
M
F
F
F
F
F
F
NTP-2000
Page 1541
p-Toluenesulfonamide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20301-04
C20301
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/19/2006
MB
70-55-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 625 ppm
03 - 1250 ppm
04 - 2500 ppm
05 - 5000 ppm
06 - 10000 ppm
07 - None
08 - 0 ppm
09 - 625 ppm
10 - 1250 ppm
11 - 2500 ppm
12 - 5000 ppm
13 - 10000 ppm
14 - None
U
T
T
T
T
T
S
U
T
T
T
T
T
S
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NTP-2000, UNTREATED
NTP-2000
Page 1542
NTP-2000, UNTREATED
NTP-2000
Toxic equivalency factor evaluation (Dioxin mixture)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96007-04
C96007B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
06/16/1998
BC
TEFDIOXINMIX
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - TERT.MIXCONTROL
02 - TERT.MIXTEQ=10
03 - TERT.MIXTEQ=22
04 - TERT.MIXTEQ=46
05 - TERT.MIXTEQ=100
V
T
T
T
T
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1543
Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96021-01
C96021
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
08/24/1998
BC
35065-27-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 10 UG/KG
03 - 100 UG/KG
04 - 300 UG/KG
05 - 1000 UG/KG
06 - 3000 UG/KG
07 - 3000 UG/KG STOP
V
T
T
T
T
T
T
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1544
Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96007-01
C96007D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
02/26/1998
BC
57465-28-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 10 NG/KG
03 - 30 NG/KG
04 - 100 NG/KG
05 - 175 NG/KG
06 - 300 NG/KG
07 - 550 NG/KG
08 - 1000 NG/KG
09 - 1000 NG/KG/STOP
V
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1545
Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
96007-99
C96007D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
10/08/1998
BC
57465-28-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 10 NG/KG
03 - 30 NG/KG
04 - 100 NG/KG
05 - 175 NG/KG
06 - 300 NG/KG
07 - 550 NG/KG
08 - 1000 NG/KG
V
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1546
Toxicogenomics study of allylbenzene & propenylbenzene class flavor constituents (TGMX)
TEST:
ROUTE:
TDMS #:
NTP #:
ACUTE
GAVAGE
20704-01
C20704
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
04/11/2007
BC
TGMXFLAVCLAS
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Untreated
02 - 0 mg/kg
03 - SAF 32.4 mg/kg
04 - SAF 324 mg/kg
05 - ISF 32.4 mg/kg
06 - ISF 324 mg/kg
07 - MEG 35.6 mg/kg
08 - MEG 356 mg/kg
09 - IEG 32.8 mg/kg
10 - IEG 328 mg/kg
11 - EGN 32.8 mg/kg
12 - EGN 328 mg/kg
13 - MY 38.4 mg/kg
14 - MY 384 mg/kg
15 - ESG 29.6 mg/kg
16 - ESG 296 mg/kg
17 - ANT 29.6 mg/kg
18 - ANT 296 mg/kg
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
NTP 2000 (IRRADIATED)
CORN OIL
Page 1547
Toxicogenomics study of allylbenzene & propenylbenzene class flavor constituents (TGMX) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20704-02
C20704
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
04/09/2007
BC
TGMXFLAVCLAS
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Untreated
02 - 0 mg/kg
03 - SAF 32.4 mg/kg
04 - SAF 324 mg/kg
05 - ISF 32.4 mg/kg
06 - ISF 324 mg/kg
07 - MEG 35.6 mg/kg
08 - MEG 356 mg/kg
09 - IEG 32.8 mg/kg
10 - IEG 328 mg/kg
11 - EGN 32.8 mg/kg
12 - EGN 328 mg/kg
13 - MY 38.4 mg/kg
14 - MY 384 mg/kg
15 - ESG 29.6 mg/kg
16 - ESG 296 mg/kg
17 - ANT 29.6 mg/kg
18 - ANT 296 mg/kg
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
NTP 2000 (IRRADIATED)
CORN OIL
Page 1548
Toxicogenomics study of allylbenzene & propenylbenzene class flavor constituents (TGMX) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
20704-03
C20704
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
04/09/2007
BC
TGMXFLAVCLAS
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Untreated
02 - 0 mg/kg
03 - SAF 32.4 mg/kg
04 - SAF 324 mg/kg
05 - ISF 32.4 mg/kg
06 - ISF 324 mg/kg
07 - MEG 35.6 mg/kg
08 - MEG 356 mg/kg
09 - IEG 32.8 mg/kg
10 - IEG 328 mg/kg
11 - EGN 32.8 mg/kg
12 - EGN 328 mg/kg
13 - MY 38.4 mg/kg
14 - MY 384 mg/kg
15 - ESG 29.6 mg/kg
16 - ESG 296 mg/kg
17 - ANT 29.6 mg/kg
18 - ANT 296 mg/kg
19 - Untreated ST
20 - 0 mg/kg ST
21 - 0mg/kg/SAFL STOP
22 - 0mg/kg/SAFH STOP
23 - 0mg/kg/ISFL STOP
24 - 0mg/kg/ISFH STOP
25 - 0mg/kg/MEGL STOP
26 - 0mg/kg/MEGH STOP
27 - 0mg/kg/IEGL STOP
28 - 0mg/kg/IEGH STOP
29 - 0mg/kg/EGNL STOP
30 - 0mg/kg/EGNH STOP
31 - 0mg/kg/MYL STOP
32 - 0mg/kg/MYH STOP
33 - 0mg/kg/ESGL STOP
34 - 0mg/kg/ESGH STOP
35 - 0mg/kg/ANTL STOP
36 - 0mg/kg/ANTH STOP
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
U
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
NTP 2000 (IRRADIATED)
CORN OIL
Page 1549
NTP 2000 (IRRADIATED)
CORN OIL
Transgenic LECM (1-Chloro-2-propanol, technical)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
05160-07
C61983D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
07/17/1996
IL
127-00-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 250 PPM
04 - 250 PPM
05 - 500 PPM
06 - 500 PPM
07 - 1000 PPM
08 - 1000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1550
Transgenic LECM (1-Chloro-2-propanol, technical) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
05160-08
C61983E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
07/05/1996
IL
127-00-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 1.25 UG TPA
03 - 1.2 MG
04 - 6.0 MG
05 - 12.0 MG
V
P
T
T
T
F
F
F
F
F
ACETONE
Page 1551
Transgenic LECM (Coconut oil acid diethanolamine condensate)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
55312-05
C55312C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/13/1996
IL
68603-42-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 1.50 UG TPA
03 - 2.5 MG
04 - 5.0 MG
05 - 7.5 MG
V
P
T
T
T
F
F
F
F
F
AQUEOUS ETHANOL (95%)
ACETONE
AQUEOUS ETHANOL (95%)
Page 1552
Transgenic LECM (Furfuryl alcohol)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
05201-07
C56224E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
07/05/1996
IL
98-00-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 1.25 UG TPA
03 - 0.25 MG
04 - 0.75 MG
05 - 1.5 MG
V
P
T
T
T
F
F
F
F
F
ACETONE
Page 1553
Transgenic LECM (Lauric acid diethanolamine condensate)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
55323-05
C55232C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/11/1996
IL
120-40-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 0 MG
03 - 5.0 MG
04 - 5.0 MG
05 - 10.0 MG
06 - 10.0 MG
07 - 20.0 MG
08 - 20.0 MG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1554
Transgenic LECM (Lauric acid diethanolamine condensate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
55323-06
C55232D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/13/1996
IL
120-40-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - O MG
02 - 1.50 UG TPA
03 - 0.4 MG
04 - 0.8 MG
05 - 1.2 MG
V
P
T
T
T
F
F
F
F
F
ACETONE
Page 1555
AQUEOUS ETHANOL (95%)
Transgenic LECM (Oleic acid diethanolamine condensate)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
91014-05
C91014B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/11/1996
IL
93-83-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 0 MG
03 - 0.4 MG
04 - 0.4 MG
05 - 0.8 MG
06 - 0.8 MG
07 - 1.2 MG
08 - 1.2 MG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1556
Transgenic LECM (Oleic acid diethanolamine condensate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
91014-06
C91014C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/13/1996
IL
93-83-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 1.50 UG TPA
03 - 0.4 MG
04 - 0.8 MG
05 - 1.2 MG
V
P
T
T
T
F
F
F
F
F
AQUEOUS ETHANOL (95%)
ACETONE
AQUEOUS ETHANOL (95%)
Page 1557
Transgenic LECM (Pentachlorophenol)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
89002-03
C89002B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
07/30/1996
IL
87-86-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1558
Transgenic LECM (Pentachlorophenol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
89002-04
C89002C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
07/05/1996
IL
87-86-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 1.25 UG TPA
03 - 0.75 MG
04 - 1.5 MG
05 - 3.0 MG
V
P
T
T
T
F
F
F
F
F
ACETONE
Page 1559
Transgenic LECM (Pyridine)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
55301-07
C55301C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
07/17/1996
IL
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 250 PPM
04 - 125 PPM
05 - 500 PPM
06 - 250 PPM
07 - 1000 PPM
08 - 500 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1560
Transgenic LECM (Pyridine) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
55301-08
C55301D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
07/05/1996
IL
110-86-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG
02 - 1.25 UG TPA
03 - 1.5 MG
04 - 3.0 MG
05 - 6.0 MG
V
P
T
T
T
F
F
F
F
F
ACETONE
Page 1561
Transgenic LECM (Tetradecanoyl phorbol acetate (TPA))
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
98005-02
C98005
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
09/11/1998
IL
16561-29-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 2.5 UG
02 - 2.5 UG
T
T
M
F
(UNSPECIFIED)
Page 1562
TRANSGENIC MODEL EVALUATION
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
SKIN
95007-18
C95007
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
03/31/1996
MB
TRAN-GEN-MOD
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
U
U
M
F
NIH-07
Page 1563
Transgenic model evaluation (p-Anisidine HCl)
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
SKIN
95007-13
C95007Q
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/09/1996
MB
20265-97-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 133 MG/KG
03 - 0 MG/KG
04 - 133 MG/KG
V
T
V
T
M
M
F
F
AQUEOUS ETHANOL (95%)
Page 1564
Transgenic model evaluation (Bromodichloromethane)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
99001-01
C99001
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG:APC
10/28/1998
IL
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - BDCM 50MG/KG
04 - BDCM 50MG/KG
05 - BDCM 100MG/KG
06 - BDCM 100MG/KG
V
V
T
T
T
T
M
F
M
F
M
F
CORN OIL
Page 1565
Transgenic model evaluation (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
99001-02
C99001B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG:APC
12/22/1998
IL
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - VEHICLE CONTROL
03 - BDCM 350PPM
04 - BCDM 350PPM
V
V
T
T
M
F
M
F
TAP WATER
Page 1566
Transgenic model evaluation (Cyclophosphamide monohydrate)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97011-01
C97011A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
12/23/1997
MB
6055-19-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 12.5 MG/KG
03 - 25 MG/KG
04 - 50 MG/KG
05 - 100 MG/KG
06 - 200 MG/KG
07 - 0 MG/KG
08 - 12.5 MG/KG
09 - 25 MG/KG
10 - 50 MG/KG
11 - 100 MG/KG
12 - 200 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
ETHANOL : WATER (1 : 1)
Page 1567
Transgenic model evaluation (Cyclophosphamide monohydrate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
97011-02
C97011B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
12/22/1997
MB
6055-19-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 10 MG/KG
03 - 20 MG/KG
04 - 40 MG/KG
05 - 60 MG/KG
06 - 120 MG/KG
07 - 0 MG/KG
08 - 10 MG/KG
09 - 20 MG/KG
10 - 40 MG/KG
11 - 60 MG/KG
12 - 120 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1568
Transgenic model evaluation (Cyclophosphamide monohydrate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-14
C97011A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
11/16/1998
MB
6055-19-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 10 MG/KG
03 - 30 MG/KG
04 - 90 MG/KG
05 - TPA CONTROL
06 - VEHICLE CONTROL
07 - 10 MG/KG
08 - 30 MG/KG
09 - 90 MG/KG
10 - TPA CONTROL
V
T
T
T
P
V
T
T
T
P
M
M
M
M
M
F
F
F
F
F
ETHANOL : WATER (1 : 1)
Page 1569
ACETONE
ETHANOL : WATER (1 : 1)
ACETONE
Transgenic model evaluation (Cyclophosphamide monohydrate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-15
C97011A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/16/1998
MB
6055-19-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 90 MG/KG
03 - VEHICLE CONTROL
04 - 90 MG/KG
V
T
V
T
M
M
F
F
ETHANOL : WATER (1 : 1)
Page 1570
Transgenic model evaluation (Cyclophosphamide monohydrate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-16
C97011B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
11/19/1998
MB
6055-19-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 10 MG/KG
03 - 30 MG/KG
04 - 60 MG/KG
05 - VEHICLE CONTROL
06 - 10 MG/KG
07 - 30 MG/KG
08 - 60 MG/KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
DEIONIZED WATER
Page 1571
Transgenic model evaluation (Cyclophosphamide monohydrate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-17
C97011B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/19/1998
MB
6055-19-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 60 MG/KG
03 - VEHICLE CONTROL
04 - 60 MG/KG
V
T
V
T
M
M
F
F
DEIONIZED WATER
Page 1572
Transgenic model evaluation (Cyclosporin A)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
GAVAGE
95007-16
C95007C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
03/25/1996
MB
59865-13-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 10 MG/KG
03 - 25 MG/KG
04 - 0 MG/KG
05 - 10 MG/KG
06 - 25 MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
ETHANOL : WATER (1 : 1)
Page 1573
Transgenic model evaluation (Cyclosporin A) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
GAVAGE
95007-17
C95007D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
03/26/1996
MB
59865-13-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 10 MG/KG
03 - 25 MG/KG
04 - 0 MG/KG
05 - 10 MG/KG
06 - 25 MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
ETHANOL : WATER (1 : 1)
Page 1574
Transgenic model evaluation (DES)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
SKIN
95007-03
C95007A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/19/1996
MB
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 830 UG/KG
03 - 0 UG/KG
04 - 830 UG/MG
V
T
V
T
M
M
F
F
AQUEOUS ETHANOL (95%)
Page 1575
Transgenic model evaluation (DES) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
SUBCUT
95007-04
C95007B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
02/20/1996
MB
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 1000 UG/KG
03 - 0 UG/KG
04 - 1000 UG/KG
V
T
V
T
M
M
F
F
AQUEOUS ETHANOL (95%)
Page 1576
Transgenic model evaluation (DES) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97011-09
C97011G
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/23/1998
BC
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 30 UG/KG
04 - 30 UG/KG
05 - 60 UG/KG
06 - 60 UG/KG
07 - 120 UG/KG
08 - 120 UG/KG
09 - 180 UG/KG
10 - 180 UG/KG
11 - 240 UG/KG
12 - 240 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1577
Transgenic model evaluation (DES) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
97011-10
C97011H
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/23/1998
BC
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 30 UG/KG
04 - 30 UG/KG
05 - 60 UG/KG
06 - 60 UG/KG
07 - 120 UG/KG
08 - 120 UG/KG
09 - 180 UG/KG
10 - 180 UG/KG
11 - 240 UG/KG
12 - 240 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1578
Transgenic model evaluation (DES) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-18
C97011G
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
04/13/1999
BC
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 480 UG/KG
04 - 480 UG/KG
V
V
T
T
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1579
Transgenic model evaluation (DES) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-19
C97011G
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
04/13/1999
BC
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 30 UG/KG
04 - 30 UG/KG
05 - 240 UG/KG
06 - 240 UG/KG
07 - 480 UG/KG
08 - 480 UG/KG
09 - TPA POSITIVE
10 - TPA POSITIVE
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AQUEOUS ETHANOL (95%)
Page 1580
Transgenic model evaluation (DES) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-20
C97011H
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
04/12/1999
BC
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 480 UG/KG
04 - 480 UG/KG
V
V
T
T
M
F
M
F
CORN OIL
Page 1581
Transgenic model evaluation (DES) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-21
C97011H
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
04/12/1999
BC
56-53-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 30 UG/KG
04 - 30 UG/KG
05 - 240 UG/KG
06 - 240 UG/KG
07 - 480 UG/KG
08 - 480 UG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1582
Transgenic model evaluation (2,4-Diaminotoluene)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
SKIN
95007-14
C95007R
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
03/20/1996
MB
95-80-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 30 MG/KG
03 - 0 MG/KG
04 - 30 MG/KG
V
T
V
T
M
M
F
F
ETHANOL : WATER (1 : 1)
Page 1583
Transgenic model evaluation (2,6-Diaminotoluene 2HCl)
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
SKIN
95007-15
C95007T
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/13/1996
MB
15481-70-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 30 MG/KG
03 - 0 MG/KG
04 - 30 MG/KG
V
T
V
T
M
M
F
F
ETHANOL : WATER (1 : 1)
Page 1584
Transgenic model evaluation (Di(2-ethylhexyl) phthalate)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-07
C97011K
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
02/04/1998
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 100 MG/KG
04 - 100 MG/KG
05 - 200 MG/KG
06 - 200 MG/KG
07 - 400 MG/KG
08 - 400 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1585
Transgenic model evaluation (Di(2-ethylhexyl) phthalate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
97011-08
C97011L
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
02/02/1998
BC
117-81-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 1500 PPM
04 - 1500 PPM
05 - 3000 PPM
06 - 3000 PPM
07 - 6000 PPM
08 - 6000 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1586
Transgenic model evaluation (Ethinyl estradiol)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97011-11
C97011E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/23/1998
BC
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 30 UG/KG
04 - 30 UG/KG
05 - 60 UG/KG
06 - 60 UG/KG
07 - 120 UG/KG
08 - 120 UG/KG
09 - 180 UG/KG
10 - 180 UG/KG
11 - 360 UG/KG
12 - 360 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL : WATER (1 : 1)
Page 1587
Transgenic model evaluation (Ethinyl estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
97011-12
C97011F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/23/1998
BC
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 30 UG/KG
04 - 30 UG/KG
05 - 60 UG/KG
06 - 60 UG/KG
07 - 120 UG/KG
08 - 120 UG/KG
09 - 180 UG/KG
10 - 180 UG/KG
11 - 360 UG/KG
12 - 360 UG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.7 % AQUEOUS METHYLCELLULOSE
Page 1588
Transgenic model evaluation (Ethinyl estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-26
C97011F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
07/19/1999
BC
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 33 UG/KG
04 - 33 UG/KG
05 - 265 UG/KG
06 - 265 UG/KG
07 - 530 UG/KG
08 - 530 UG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
0.7 % AQUEOUS METHYLCELLULOSE
Page 1589
Transgenic model evaluation (Ethinyl estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-27
C97011F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
07/19/1999
BC
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 530 UG/KG
04 - 530 UG/KG
V
V
T
T
M
F
M
F
0.7 % AQUEOUS METHYLCELLULOSE
Page 1590
Transgenic model evaluation (Ethinyl estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-28
C97011E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
07/20/1999
BC
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 33 UG/KG
04 - 33 UG/KG
05 - 265 UG/KG
06 - 265 UG/KG
07 - 530 UG/KG
08 - 530 UG/KG
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
ETHANOL : WATER (1 : 1)
Page 1591
Transgenic model evaluation (Ethinyl estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-29
C97011E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
07/20/1999
BC
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0 UG/KG
03 - 530 UG/KG
04 - 530 UG/KG
V
V
T
T
M
F
M
F
ETHANOL : WATER (1 : 1)
Page 1592
ENDOCRINE DISRUPTOR(Ethinyl Estradiol)
TEST:
ROUTE:
TDMS #:
NTP #:
MULTIGEN CHRONIC
FEED
99920-91
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
01/29/2001
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F0 CONTROL
02 - F0 2.0 PPB
03 - F0 10 PPB
04 - F0 50 PPB
05 - F0 CONTROL
06 - F0 2.0 PPB
07 - F0 10 PPB
08 - F0 50 PPB
09 - F1 Control
10 - F1 2.0 PPB
11 - F1 10 PPB
12 - F1 50 PPB
13 - F1 CONTROL
14 - F1 2.0 PPB
15 - F1 10 PPB
16 - F1 50 PPB
17 - F2 CONTROL
18 - F2 2.0 PPB
19 - F2 10 PPB
20 - F2 50 PPB
21 - F2 CONTROL
22 - F2 2.0 PPB
23 - F2 10 PPB
24 - F2 50 PPB
25 - F3 CONTROL
26 - F3/2PPB TO CTRL
27 - F3/10PPB TO CTRL
28 - F3/50PPB TO CTRL
29 - F3 CONTROL
30 - F3/2PPB TO CTRL
31 - F3/10PPB TO CTRL
32 - F3/50PPB TO CTRL
33 - F4 CONTROL
34 - F4/2PPB TO CTRL
35 - F4/10PPB TO CTR
36 - F4/50PPB TO CTRL
37 - F4 CONTROL
38 - F4/2PPB TO CTRL
39 - F4/10PPB TO CTRL
40 - F4/50PPB TO CTRL
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 1593
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
MULTIGEN CHRONIC
FEED
99920-92
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
05/14/2001
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1 0PPB
02 - F1 2PPB
03 - F1 10 PPB
04 - F1 50 PPB
05 - F1/2PPB TO CTL
06 - F1/10PPB TO CTL
07 - F1/50PPB TO CTL
08 - F1 0PPB
09 - F1 2PPB
10 - F1 10PPB
11 - F1 50PPB
12 - F1/2PPB TO CTL
13 - F1/10PPB TO CTL
14 - F1/50PPB TO CTL
15 - F3 0PPB
16 - F3 /2PPB TO CTL
17 - F3/10PPB TO CTL
18 - F3/50PPB TO CTL
19 - F3 0PPB
20 - F3/2PPB TO CTL
21 - F3/10 PPB TO CTL
22 - F3/50 PPB TO CTL
V
T
T
T
T
T
T
V
T
T
T
T
T
T
V
T
T
T
V
T
T
T
F
F
F
F
F
F
F
M
M
M
M
M
M
M
F
F
F
F
M
M
M
M
(UNSPECIFIED)
Page 1594
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99920-93
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
05/14/2001
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F3 0PPB
02 - F3/2PPB TO CTL
03 - F3/10PPBTO CTL
04 - F3/50PPBTO CTL
05 - F3 0PPB
06 - F3/2PPB TO CTL
07 - F3/10PPBTO CTL
08 - F3/50PPBTO CTL
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
5k96 Meal
Page 1595
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99920-94
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
12/11/2000
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1 0PPB
02 - F1 2PPB
03 - F1 10 PPB
04 - F1 50 PPB
05 - F1/2PPB TO CTL
06 - F1/10PPB TO CTL
07 - F1/50PPB TO CTL
08 - F1 0PPB
09 - F1 2PPB
10 - F1 10PPB
11 - F1 50PPB
12 - F1/2PPB TO CTL
13 - F1/10PPB TO CTL
14 - F1/50PPB TO CTL
V
T
T
T
T
T
T
V
T
T
T
T
T
T
F
F
F
F
F
F
F
M
M
M
M
M
M
M
5k96 Meal
Page 1596
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99920-95
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
08/27/2001
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F4 CONTROL
02 - F4/2PPB TO CTRL
03 - F4/10PPB TO CTRL
04 - F4/50PPB TO CTRL
05 - F4 CONTROL
06 - F4/2PPB TO CTRL
07 - F4/10PPB TO CTRL
08 - F4/50PPB TO CTRL
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
NIH-31
Page 1597
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99920-96
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
05/14/2001
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F3 CONTROL
02 - F3/2PPB TO CTRL
03 - F3/10PPB TO CTRL
04 - F3/50PPB TO CTRL
05 - F3 CONTROL
06 - F3/2PPB TO CTRL
07 - F3/10PPB TO CTRL
08 - F3/50PPB TO CTRL
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
NIH-31
Page 1598
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99920-97
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
01/29/2001
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F2 CONTROL
02 - F2 2.0 PPB
03 - F2 10 PPB
04 - F2 50 PPB
05 - F2 CONTROL
06 - F2 2.0 PPB
07 - F2 10 PPB
08 - F2 50 PPB
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
NIH-31
Page 1599
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99920-98
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
10/23/2000
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F1 CONTROL
02 - F1 2.0 PPB
03 - F1 10 PPB
04 - F1 50 PPB
05 - F1 CONTROL
06 - F1 2.0 PPB
07 - F1 10 PPB
08 - F1 50 PPB
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
NIH-31
Page 1600
ENDOCRINE DISRUPTOR(Ethinyl Estradiol) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
99920-99
MG96006
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, CD
08/08/2000
NR
57-63-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - F0 CONTROL
02 - F0 2.0 PPB
03 - F0 10 PPB
04 - F0 50 PPB
05 - F0 CONTROL
06 - F0 2.0 PPB
07 - F0 10 PPB
08 - F0 50 PPB
V
T
T
T
V
T
T
T
F
F
F
F
M
M
M
M
NIH-31
Page 1601
Transgenic model evaluation (8-Hydroxyquinoline)
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
FEED
95007-10
C95007L
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
03/01/1996
MB
148-24-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 3000 PPM8-OHQ
03 - 1200 PPMROT
04 - 200 PPM 2,4-DAT
05 - 200 PPM 2,6-DAT
06 - 0 PPM
07 - 3000 PPM8-OHQ
08 - 1200 PPMROT
09 - 200 PPM 2,4-DAT
10 - 200 PPM 2,6-DAT
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
F
F
F
F
F
NIH-07
Page 1602
Transgenic Model Evaluation II (Acesulfame Potassium)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
FEED
99039-01
C99039
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
01/31/2000
MB
55589-62-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.3%
03 - 1.0 %
04 - 3.0 %
05 - POSITIVECONTROL
06 - VEHICLE CONTROL
07 - 0.3 %
08 - 1.0%
09 - 3.0%
10 - POSITIVECONTROL
V
T
T
T
P
V
T
T
T
P
M
M
M
M
M
F
F
F
F
F
NTP-2000
Page 1603
ACETONE
NTP-2000
ACETONE
Transgenic Model Evaluation II (Acesulfame Potassium) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
FEED
99039-02
C99039
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
02/02/2000
MB
55589-62-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.3 %
03 - 1.0 %
04 - 3.0 %
05 - VEHICLE CONTROL
06 - 0.3 %
07 - 1.0 %
08 - 3.0 %
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
NTP-2000
Page 1604
Transgenic model evaluation II (Aspartame)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
FEED
99033-01
C99033
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
10/11/1999
MB
22839-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 3125 PPM
03 - 6250 PPM
04 - 12500 PPM
05 - 25000 PPM
06 - 50000 PPM
07 - TPA CONTROL
08 - VEHICLE CONTROL
09 - 3125 PPM
10 - 6250 PPM
11 - 12500 PPM
12 - 25000 PPM
13 - 50000 PPM
14 - TPA CONTROL
V
T
T
T
T
T
P
V
T
T
T
T
T
P
M
M
M
M
M
M
M
F
F
F
F
F
F
F
NTP-2000
Page 1605
ACETONE
NTP-2000
ACETONE
Transgenic model evaluation II (Aspartame) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
FEED
99033-02
C99033
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
10/14/1999
MB
22839-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 3125 PPM
03 - 6250 PPM
04 - 12500 PPM
05 - 25000 PPM
06 - 50000 PPM
07 - VEHICLE CONTROL
08 - 3125 PPM
09 - 6250 PPM
10 - 12500 PPM
11 - 25000 PPM
12 - 50000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NTP-2000
Page 1606
Transgenic model evaluation II (Aspartame) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
99033-03
C99033B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG:P16-INK4A
10/27/1999
MB
22839-47-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 3125 PPM
03 - 6250 PPM
04 - 12500 PPM
05 - 25000 PPM
06 - 50000 PPM
07 - VEHICLE CONTROL
08 - 3125 PPM
09 - 6250 PPM
10 - 12500 PPM
11 - 25000 PPM
12 - 50000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NTP-2000
Page 1607
Transgenic model evaluation II (Benzene)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
99034-01
C99034
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG:P16-INK4A
10/29/1999
BC
71-43-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1608
Transgenic model evaluation II (Glycidol)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
99035-01
C99035
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG:P16-INK4A
02/03/2000
BC
556-52-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - 200 MG/KG
10 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1609
Transgenic model evaluation II (Phenolphthalein)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
99036-01
C99036
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG:P16-INK4A
12/08/1999
BC
77-09-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 200 PPM
04 - 200 PPM
05 - 375 PPM
06 - 375 PPM
07 - 750 PPM
08 - 750 PPM
09 - 3000 PPM
10 - 3000 PPM
11 - 12,000 PPM
12 - 12,000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1610
Transgenic model evaluation (Melphalan)
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
SKIN
95007-05
C95007E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/13/1996
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 8.3MG/KG
03 - 25 MG/KG
04 - 0 MG/KG
05 - 8.3MG/KG
06 - 25 MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
METHANOL
Page 1611
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
INTP INJ
95007-06
C95007F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
02/14/1996
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.3 MG/KG
03 - 1.5 MG/KG
04 - 0 MG/KG
05 - 0.3 MG/KG
06 - 1.5 MG/KG
V
T
T
V
T
T
M
M
M
F
F
F
PROPYLENE GLYCOL
Page 1612
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97011-03
C97011C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
12/25/1997
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.25 MG/KG
03 - 0.5 MG/KG
04 - 1.0 MG/KG
05 - 2.0 MG/KG
06 - 4.0 MG/KG
07 - 0 MG/KG
08 - 0.25 MG/KG
09 - 0.5 MG/KG
10 - 1.0 MG/KG
11 - 2.0 MG/KG
12 - 4.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
METHANOL
Page 1613
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
97011-04
C97011D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
12/24/1997
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0.25 MG/KG
03 - 0.5 MG/KG
04 - 1.0 MG/KG
05 - 2.0 MG/KG
06 - 4.0 MG/KG
07 - 0 MG/KG
08 - 0.25 MG/KG
09 - 0.5 MG/KG
10 - 1.0 MG/KG
11 - 2.0 MG/KG
12 - 4.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1614
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
97011-13
C97011M
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/16/1998
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 1.0 MG/KG
03 - 2.0 MG/KG
04 - 4.0 MG/KG
05 - 8.0 MG/KG
06 - 16.0 MG/KG
07 - VEHICLE CONTROL
08 - 1.0 MG/KG
09 - 2.0 MG/KG
10 - 4.0 MG/KG
11 - 8.0 MG/KG
12 - 16.0 MG/KG
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
CORN OIL
Page 1615
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-22
C97011C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
06/01/1999
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.25 MG/KG
03 - 1.0 MG/KG
04 - 4.0 MG/KG
05 - TPA CONTROL
06 - VEHICLE CONTROL
07 - 0.25 MG/KG
08 - 1.0 MG/KG
09 - 4.0 MG/KG
10 - TPA CONTROL
V
T
T
T
P
V
T
T
T
P
M
M
M
M
M
F
F
F
F
F
METHANOL
Page 1616
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-23
C97011C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
06/01/1999
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 4.0 MG/KG
03 - VEHICLE CONTROL
04 - 4.0 MG/KG
V
T
V
T
M
M
F
F
METHANOL
Page 1617
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-24
C97011D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
06/10/1999
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 0.25 MG/KG
03 - 1.0 MG/KG
04 - 4.0 MG/KG
05 - VEHICLE CONTROL
06 - 0.25 MG/KG
07 - 1.0 MG/KG
08 - 4.0 MG/KG
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
CORN OIL
Page 1618
Transgenic model evaluation (Melphalan) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97011-25
C97011D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
06/10/1999
MB
148-82-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE CONTROL
02 - 4.0 MG/KG
03 - VEHICLE CONTROL
04 - 4.0 MG/KG
V
T
V
T
M
M
F
F
CORN OIL
Page 1619
Transgenic model evaluation (N-Methylolacrylamide)
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
GAVAGE
95007-07
C95007G
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/08/1996
MB
924-42-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 50 MG/KG
03 - 0 MG/KG
04 - 50 MG/KG
V
T
V
T
M
M
F
F
DEIONIZED WATER
Page 1620
Transgenic model evaluation (N-Methylolacrylamide) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
24-WEEK
SKIN
95007-08
C95007H
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
03/18/1996
MB
924-42-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 50 MG/KGN-MA
03 - 225MG/KGRES
04 - 225MG/KG8-OHQ
05 - 166MG/KGROT
06 - 0 MG/KG
07 - 50 MG/KGN-MA
08 - 225MG/KGRES
09 - 225MG/KG8-OHQ
10 - 166MG/KGROT
V
T
T
T
T
V
T
T
T
T
M
M
M
M
M
F
F
F
F
F
ACETONE
Page 1621
Transgenic model evaluation (Methylphenidate hydrochloride)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
95007-01
C95007V
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
11/06/1995
BC
298-59-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 50 PPM
04 - 50 PPM
05 - 250 PPM
06 - 250 PPM
07 - 500 PPM
08 - 500 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1622
Transgenic model evaluation (Methylphenidate hydrochloride) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
95007-02
C95007V
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
11/08/1995
BC
298-59-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 50 PPM
04 - 50 PPM
05 - 250 PPM
06 - 250 PPM
07 - 500 PPM
08 - 500 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1623
Transgenic model evaluation (Phenolphthalein)
TEST:
ROUTE:
TDMS #:
NTP #:
1-YEAR
FEED
05182-05
C55798C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
01/30/1996
IL
77-09-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 200 PPM
03 - 375 PPM
04 - 750 PPM
05 - 3000 PPM
06 - 12000 PPM
V
T
T
T
T
T
F
F
F
F
F
F
NIH-07
Page 1624
Transgenic model evaluation (Resorcinol)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
GAVAGE
95007-09
C95007J
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
03/21/1996
MB
108-46-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 225 MG/KG
03 - 0 MG/KG
04 - 225 MG/KG
V
T
V
T
M
M
F
F
AQUEOUS ETHANOL (95%)
DEIONIZED WATER
AQUEOUS ETHANOL (95%)
DEIONIZED WATER
Page 1625
Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
SKIN
95007-11
C95007O
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/12/1996
MB
1746-01-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0.166 UG/KG
03 - 0 UG/KG
04 - 0.166 UG/KG
V
T
V
T
M
M
F
F
ACETONE
Page 1626
Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
25-WEEK
GAVAGE
95007-12
C95007P
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
02/13/1996
MB
1746-01-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 UG/KG
02 - 0.25 UG/KG
03 - 0 UG/KG
04 - 1.0 UG/KG
V
T
V
T
M
M
F
F
CORN OIL : ACETONE (99 : 1)
Page 1627
Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97012-01
C97012A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
04/28/1998
BC
1746-01-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 NG/KG
02 - 105 NG/KG
03 - 450 NG/KG
04 - 1250 NG/KG
V
T
T
T
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1628
Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97012-02
C97012B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
04/27/1998
BC
1746-01-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - POSITIVETPA
02 - 0 NG/KG
03 - 5 NG/KG
04 - 17 NG/KG
05 - 36 NG/KG
06 - 76 NG/KG
07 - 121 NG/KG
08 - 166 NG/KG
09 - 355 NG/KG
10 - 760 NG/KG
P
V
T
T
T
T
T
T
T
T
F
F
F
F
F
F
F
F
F
F
(UNSPECIFIED)
ACETONE
Page 1629
Transgenic model evaluation (WY-14643)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97011-05
C97011I
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
02/05/1998
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 2 MG/KG
04 - 2 MG/KG
05 - 10 MG/KG
06 - 10 MG/KG
07 - 20 MG/KG
08 - 20 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1630
Transgenic model evaluation (WY-14643) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
FEED
97011-06
C97011J
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HOMO
02/03/1998
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 10 PPM
04 - 10 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP-2000
Page 1631
Triamterene
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05087-01
C56042B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/10/1984
BC
396-01-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 150 PPM
03 - 300 PPM
04 - 600 PPM
05 - 0 PPM
06 - 150 PPM
07 - 300 PPM
08 - 600 PPM
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1632
Triamterene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05087-02
C56042B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/17/1984
BC
396-01-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 100 PPM
03 - 200 PPM
05 - 0 PPM
06 - 100 PPM
07 - 200 PPM
U
T
T
U
T
T
M
M
M
F
F
F
NIH-07
Page 1633
Triamterene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05087-03
C56042B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/26/1985
BC
396-01-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0PPM
02 - 400 PPM
03 - 0PPM
04 - 400 PPM
U
T
U
T
M
M
F
F
NIH-07
(UNSPECIFIED)
NIH-07
(UNSPECIFIED)
Page 1634
Tribromomethane
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05053-01
C55130
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/19/1981
MA
75-25-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE 46 VM
02 - 0.1 G/KG 46 LM
03 - 0.2 G/KG 46 HM
04 - VEHICLE 46 VF
05 - 0.1 G/KG 46 LF
06 - 0.2 G/KG 46 HF
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1635
Tribromomethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05053-02
C55130
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/05/1981
MA
75-25-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHICLE 46 VM
02 - .05 G/KG 46 LM
03 - 0.1 G/KG 46 HM
04 - VEHICLE 46 VF
05 - 0.1 G/KG 46 LF
06 - 0.2 G/KG 46 HF
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1636
Tricaprylin
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05145-01
C62215
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/23/1986
MA
538-23-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ML/KG
02 - 2.5 ML/KG
03 - 5.0 ML/KG
04 - 10.0 ML/KG
U
T
T
T
M
M
M
M
NIH-07
(UNSPECIFIED)
Page 1637
Trichlorfon
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05151-03
C54831B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/14/1987
BC
52-68-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 62 PPM
04 - 62 PPM
05 - 185 PPM
06 - 185 PPM
07 - 555 PPM
08 - 555 PPM
09 - 1666 PPM
10 - 1666 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1638
Trichlorfon (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05151-04
C54831B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/21/1987
BC
52-68-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 62 PPM
04 - 62 PPM
05 - 185 PPM
06 - 185 PPM
07 - 555 PPM
08 - 555 PPM
09 - 1666 PPM
10 - 1666 PPM
11 - 5000 PPM
12 - 5000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1639
1,1,1-Trichloroethane
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
04626-01
C04626C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/16/1990
MA
71-55-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD
02 - UNTREATD
03 - VEHICLE
04 - VEHICLE
05 - 0.5%
06 - 0.5%
07 - 1.0%
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
13 - 8.0%
14 - 8.0%
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1640
MICROCAPSULES
NIH-07
1,1,1-Trichloroethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
04626-02
C04626C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/09/1990
MA
71-55-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD
02 - UNTREATD
03 - VEHICLE
04 - VEHICLE
05 - 0.5%
06 - 0.5%
07 - 1.0 %
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
13 - 8.0%
14 - 8.0%
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1641
MICROCAPSULES
NIH-07
1,1,1-TRICHLOROETHANE
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
04626-03
C04626
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/16/1990
MA
71-55-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - UNTREATD
02 - UNTREATD
03 - VEHICLE
04 - VEHICLE
05 - 0.5%
06 - 0.5%
07 - 1.0%
08 - 1.0%
09 - 2.0%
10 - 2.0%
11 - 4.0%
12 - 4.0%
13 - 8.0%
14 - 8.0%
U
U
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1642
MICROCAPSULES
NIH-07
1,2,3-Trichloropropane
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05111-01
C60220B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/03/1985
MA
96-18-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 3 MG/KG
04 - 3 MG/KG
05 - 10 MG/KG
06 - 10 MG/KG
07 - 30 MG/KG
08 - 30 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1643
1,2,3-Trichloropropane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05111-02
C60220B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/25/1985
MA
96-18-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 6 MG/KG
04 - 6 MG/KG
05 - 20 MG/KG
06 - 20 MG/KG
07 - 60 MG/KG
08 - 60 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1644
Triclosan
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
Dermal
03039-01
C03039B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
10/11/2011
NR
3380-34-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - TR1 125mg/kg M
02 - TR2 58mg/kg M
03 - TR3 27mg/kg M
04 - TR4 12.5mg/kg M
05 - TR5 5.8mg/kg M
06 - TR6 MCONTROL
07 - TR7 125mg/kg F
08 - TR8 58mg/kg F
09 - TR9 27mg/kg F
10 - TR10 12.5mg/kg F
11 - TR11 5.8mg/kg F
12 - TR12 FCONTROL
T
T
T
T
T
V
T
T
T
T
T
V
M
M
M
M
M
M
F
F
F
F
F
F
Ethanol
Page 1645
Triclosan (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
Dermal
03039-02
C03039B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/11/2013
NR
3380-34-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Veh ctrlFemale
02 - Veh ctrlMale
03 - Tri 1.25Female
04 - Tri 1.25Male
05 - Tri 2.7 Female
06 - Tri 2.7 Male
07 - Untreat Female
08 - Untreat Male
09 - Tri 5.8 Female
10 - Tri 5.8 Male
11 - Tri 12.5Female
12 - Tri 12.5Male
V
V
T
T
T
T
U
U
T
T
T
T
F
M
F
M
F
M
F
M
F
M
F
M
Ethanol
Page 1646
NTP-2000
Ethanol
Tricresyl Phosphate
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05100-01
C61041B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/28/1984
BC
1330-78-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 900 PPM
03 - 1700 PPM
04 - 3300 PPM
05 - 6600 PPM
06 - 13000 PPM
07 - 0 PPM
08 - 900 PPM
09 - 1700 PPM
10 - 3300 PPM
11 - 6600 PPM
12 - 13000 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1647
Tricresyl Phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05100-02
C61041B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/05/1984
BC
1330-78-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 250 PPM
03 - 500 PPM
04 - 1000 PPM
05 - 2100 PPM
06 - 4200 PPM
07 - 0 PPM
08 - 250 PPM
09 - 500 PPM
10 - 1000 PPM
11 - 2100 PPM
12 - 4200 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-07
Page 1648
Tricresyl Phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05100-03
C61041B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/18/1986
BC
1330-78-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 75 PPM
04 - 75 PPM
05 - 150 PPM
06 - 150 PPM
07 - 300 PPM
08 - 300 PPM
09 - 600 PPM 23 STOP
10 - 600 PPM 23 STOP
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1649
Tricresyl Phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05100-04
C61041B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/09/1986
BC
1330-78-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 60 PPM
04 - 60 PPM
05 - 125 PPM
06 - 125 PPM
07 - 250 PPM
08 - 250 PPM
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NIH-07
Page 1650
Triethanolamine
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05109-07
C61621B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/30/1986
BC
102-71-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25 G/KG
06 - 0.25 G/KG
07 - .5 G/KG
08 - .5 G/KG
09 - 1.0 G/KG
10 - 1.0 G/KG
11 - 2.0 G/KG
12 - 2.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1651
Triethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
DERM SOL
05109-08
C61621B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/11/1986
BC
102-71-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.25 G/KG
04 - 0.25 G/KG
05 - 0.5 G/KG
06 - 0.5 G/KG
07 - 1.0 G/KG
08 - 1.0 G/KG
09 - 2.0 G/KG
10 - 2.0 G/KG
11 - 4.0 G/KG
12 - 4.0 G/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1652
Triethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
MATING TRIAL
DERM SOL
05109-09
C61621B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/27/1988
BC
102-71-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.125 G/KG
04 - 0.125 G/KG
05 - 0.25G/KG
06 - 0.25G/KG
07 - 0.5 G/KG
08 - 0.5 G/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1653
Triethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
MATING TRIAL
DERM SOL
05109-10
C61621B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, CD-1 CRL
12/14/1987
BC
102-71-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/KG
02 - 0 G/KG
03 - 0.5 G/KG
04 - 0.5 G/KG
05 - 1.0 G/KG
06 - 1.0 G/KG
07 - 2.0 G/KG
08 - 2.0 G/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1654
Triethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05109-11
C61621D
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/14/1988
BC
102-71-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 32 MG/KG
04 - 63 MG/KG
05 - 63 MG/KG
06 - 125 MG/KG
07 - 125 MG/KG
08 - 250 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1655
Triethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05109-12
C61621D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/31/1988
BC
102-71-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 200 MG/KG
04 - 100 MG/KG
05 - 630 MG/KG
06 - 300 MG/KG
07 - 2000 MG/KG
08 - 1000 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1656
Triethanolamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
05109-14
C61621E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/23/1998
BC
102-71-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 200 MG/KG
04 - 100 MG/KG
05 - 630 MG/KG
06 - 300 MG/KG
07 - 2000 MG/KG
08 - 1000 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1657
Triethylamine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
99019-01
C99019
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/23/2002
BN
121-44-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
09 - 800 PPM
10 - 800 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1658
Triethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
99019-02
C99019
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/23/2002
BN
121-44-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 100 PPM
04 - 100 PPM
05 - 200 PPM
06 - 200 PPM
07 - 400 PPM
08 - 400 PPM
09 - 800 PPM
10 - 800 PPM
11 - 1000 PPM
12 - 1000 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1659
Triethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
99019-03
C99019
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/20/2003
BN
121-44-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 12.5 PPM
04 - 12.5 PPM
05 - 25 PPM
06 - 25 PPM
07 - 50 PPM
08 - 50 PPM
09 - 100 PPM
10 - 100 PPM
11 - 200 PPM
12 - 200 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1660
Triethylamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
99019-04
C99019
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/20/2003
BN
121-44-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 12.5 PPM
04 - 12.5 PPM
05 - 25 PPM
06 - 25 PPM
07 - 50 PPM
08 - 50 PPM
09 - 100 PPM
10 - 100 PPM
11 - 200 PPM
12 - 200 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1661
Trimethylolpropane triacrylate
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
88133-01
C88133
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/06/1996
BC
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 200 MG/KG
12 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1662
Trimethylolpropane triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
88133-02
C88133
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/07/1996
BC
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 12.5 MG/KG
04 - 12.5 MG/KG
05 - 25 MG/KG
06 - 25 MG/KG
07 - 50 MG/KG
08 - 50 MG/KG
09 - 100 MG/KG
10 - 100 MG/KG
11 - 200 MG/KG
12 - 200 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1663
Trimethylolpropane triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
88133-03
C88133
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/09/1996
BC
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1664
Trimethylolpropane triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
88133-04
C88133
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/11/1996
BC
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1665
Trimethylolpropane triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
SKIN
88133-05
C88133
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/09/1996
BC
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1666
Trimethylolpropane triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
88133-06
C88133B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
07/20/1998
BC
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.75 MG/KG
04 - 0.75 MG/KG
05 - 1.5 MG/KG
06 - 1.5 MG/KG
07 - 3 MG/KG
08 - 3 MG/KG
09 - 6 MG/KG
10 - 6 MG/KG
11 - 12 MG/KG
12 - 12 MG/KG
13 - POSITIVETPA
14 - POSITIVETPA
V
V
T
T
T
T
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1667
Trimethylolpropane triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
88133-07
C88133C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/18/2005
SO
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.3 MG/KG
04 - 0.3 MG/KG
05 - 1.0 MG/KG
06 - 1.0 MG/KG
07 - 3.0 MG/KG
08 - 3.0 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1668
Trimethylolpropane triacrylate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
SKIN
88133-08
C88133C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/13/2004
SO
15625-89-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 0.3 MG/KG
04 - 0.3 MG/KG
05 - 1.0 MG/KG
06 - 1.0 MG/KG
07 - 3.0 MG/KG
08 - 3.0 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1669
2,4,7-Trinitro-fluoren-9-one
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05192-05
C61961B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
04/04/1988
SO
129-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.1%
04 - 0.1%
05 - 0.2%
06 - 0.2%
07 - 0.4%
08 - 0.4%
09 - 0.8%
10 - 0.8%
11 - 1.6%
12 - 1.6%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1670
2,4,7-Trinitro-fluoren-9-one (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
05192-06
C61961B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/11/1988
SO
129-79-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0.0%
02 - 0.0%
03 - 0.3125%
04 - 0.3125%
05 - 0.625%
06 - 0.625%
07 - 1.25%
08 - 1.25%
09 - 2.5%
10 - 2.5%
11 - 5.0%
12 - 5.0%
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NIH-07
Page 1671
Tris(2-Chloroethyl) Phosphate
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05042-01
C60128
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/07/1982
MB
115-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 44MG/KG LOW MALE
03 - 88 MG/KGHIGHMALE
04 - CONTROL FEMALE
05 - 44MG/KG LOW FEM
06 - 88 MG/KG HIGHFEM
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1672
Tris(2-Chloroethyl) Phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
05042-02
C60128
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/13/1982
MB
115-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL MALE
02 - 175MG/KGLOW MALE
03 - 350MG/KGHIGHMALE
04 - CONTROL FEMALE
05 - 175MG/KGLOW FEM
06 - 350MG/KG HIGHFEM
V
T
T
V
T
T
M
M
M
F
F
F
CORN OIL
Page 1673
Tris(Chloropropyl)phosphate
TEST:
ROUTE:
TDMS #:
NTP #:
90 DAY W/PN EXP
FEED
20712-01
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/13/2009
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 0 ppm
03 - 2500 ppm
04 - 2500 ppm
05 - 5000 ppm
06 - 5000 ppm
07 - 10000 ppm
08 - 10000 ppm
09 - 20000 ppm
10 - 20000 ppm
U
U
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1674
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-WEEK
FEED
20712-02
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
09/10/2009
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm
02 - 0 ppm
03 - 1250 ppm
04 - 1250 ppm
05 - 2500 ppm
06 - 2500 ppm
07 - 5000 ppm
08 - 5000 ppm
09 - 10000 ppm
10 - 10000 ppm
11 - 20000 ppm
12 - 20000 ppm
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1675
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
Chronic PN
FEED
20712-03
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
12/12/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm males
02 - 0 ppm females
03 - 2500 ppm males
04 - 2500 ppm females
05 - 5000 ppm males
06 - 5000 ppm females
07 - 10000 ppm males
08 - 10000 ppm female
09 - 20000 ppm males
10 - 20000 ppm female
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NIH-07 (IRRADIATED)
Page 1676
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
20712-04
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
10/24/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm males
02 - 0 ppm females
03 - 1250 ppm males
04 - 2500 ppm females
05 - 2500 ppm males
06 - 5000ppm females
07 - 5000 ppm males
08 - 10000ppm females
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1677
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
20712-91
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
12/12/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 ppm males
02 - 0 ppm females
03 - 2500 ppm males
04 - 2500 ppm females
05 - 5000 ppm males
06 - 5000 ppm females
07 - 10000 ppm males
08 - 10000 ppm female
09 - 20000 ppm males
10 - 20000 ppm female
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
NIH-07 (IRRADIATED)
Page 1678
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
SPECIAL STUDY
FEED
20712-94
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/N
10/24/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm Males SS
02 - 0ppm females SS
03 - 1250ppm males SS
04 - 2500ppmfemalesSS
05 - 2500ppm males SS
06 - 5000ppmfemalesSS
07 - 5000ppm malesSS
08 - 10000ppmfemaleSS
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
NTP 2000 (IRRADIATED)
Page 1679
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
20712-96
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/14/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm FemalePup
02 - 2500ppmFemalePup
03 - 5000ppmFemalePup
04 - 10000ppmFmalePup
05 - 20000ppmFmalePup
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 1680
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
20712-97
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/14/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm MalePup
02 - 2500ppm MalePup
03 - 5000ppm MalePup
04 - 10000ppm MalePup
05 - 20000ppm MalePup
V
T
T
T
T
M
M
M
M
M
NIH-07 (IRRADIATED)
Page 1681
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
20712-98
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
11/14/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm DamLac
02 - 2500ppm DamLac
03 - 5000ppm DamLac
04 - 10000ppm DamLac
05 - 20000ppm DamLac
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 1682
Tris(Chloropropyl)phosphate (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
FEED
20712-99
C20712
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
10/23/2011
BC
13674-84-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0ppm DamGes
02 - 2500ppm DamGes
03 - 5000ppm DamGes
04 - 10000ppm DamGes
05 - 20000ppm DamGes
V
T
T
T
T
F
F
F
F
F
NIH-07 (IRRADIATED)
Page 1683
Turmeric, oleoresin (curcumin)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05084-01
C60015
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/24/1984
MA
8024-37-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM MALE
02 - 2,000 PPM MALE
03 - 10,000 PPM MALE
04 - 50,000 PPM MALE
06 - 0 PPM FEMALE
07 - 2,000 PPM FEM
08 - 10,000 PPM FEM
09 - 50,000 PPM FEM
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1684
Turmeric, oleoresin (curcumin) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
05084-02
C60015
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/05/1984
MA
8024-37-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM MALE
02 - 2,000 PPM MALE
03 - 10,000 PPM MALE
04 - 50,000 PPM MALE
06 - 0 PPM FEMALE
07 - 2,000 PPM FEM
08 - 10,000 PPM FEM
09 - 50,000 PPM FEM
U
T
T
T
U
T
T
T
M
M
M
M
F
F
F
F
NIH-07
Page 1685
Training Compound
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
12345-67
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/06/2014
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Test Vehicle
V
M
CORN OIL
Page 1686
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
12345-68
C99999
TREATMENT GROUP
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(NOT DEFINED)
CS
123-4-56
ROLE
SEX
Page 1687
VEHICLE(S)
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
80000-02
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/24/2012
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.3 G/L
04 - 0.3 G/L
05 - 0.6 G/L
06 - 0.6 G/L
07 - 1.2 G/L
08 - 1.2 G/L
09 - 2.4 G/L
10 - 2.4 G/L
11 - 4.8 G/L
12 - 4.8 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1688
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
80000-03
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/24/2012
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.3 G/L
04 - 0.3 G/L
05 - 0.6 G/L
06 - 0.6 G/L
07 - 1.2 G/L
08 - 1.2 G/L
09 - 2.4 G/L
10 - 2.4 G/L
11 - 4.8 G/L
12 - 4.8 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1689
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
80000-04
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/24/2012
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.3 G/L
04 - 0.3 G/L
05 - 0.6 G/L
06 - 0.6 G/L
07 - 1.2 G/L
08 - 1.2 G/L
09 - 2.4 G/L
10 - 2.4 G/L
11 - 4.8 G/L
12 - 4.8 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1690
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
80000-05
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/24/2012
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.3 G/L
04 - 0.3 G/L
05 - 0.6 G/L
06 - 0.6 G/L
07 - 1.2 G/L
08 - 1.2 G/L
09 - 2.4 G/L
10 - 2.4 G/L
11 - 4.8 G/L
12 - 4.8 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1691
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
80000-06
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/24/2012
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.3 G/L
04 - 0.3 G/L
05 - 0.6 G/L
06 - 0.6 G/L
07 - 1.2 G/L
08 - 1.2 G/L
09 - 2.4 G/L
10 - 2.4 G/L
11 - 4.8 G/L
12 - 4.8 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1692
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
80000-07
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/24/2012
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 G/L
02 - 0 G/L
03 - 0.3 G/L
04 - 0.3 G/L
05 - 0.6 G/L
06 - 0.6 G/L
07 - 1.2 G/L
08 - 1.2 G/L
09 - 2.4 G/L
10 - 2.4 G/L
11 - 4.8 G/L
12 - 4.8 G/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1693
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
INT CANN
99999-10
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
(NOT DEFINED)
MB
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - VEHCONTRCOHRTA
02 - VEHCONTRCOHRTB
03 - VEHCONTRCOHRTC
04 - VEHCONTRCOHRTD
05 - VEHCONTRCOHR E
06 - 2-8ADHAQP1COHTA
07 - 2-8ADHAQP1COHTB
08 - 208ADHAQP1COHTC
09 - 2-8ADHAQP1COHTD
10 - 2-8ADHAQP1COHTE
11 - 8-9ADHAQP1COHTA
12 - 8-9ADHAQP1COHTB
13 - 8-9ADHAQP1COHTC
14 - 8-9ADHAQP1COHTD
15 - 8-9AJDAQP1COHTE
16 - 2-11ADHAQP1COHTA
17 - 2-11ADHAQP1COHTB
18 - 2-11ADHAQP1COHTC
19 - 2-11ADHAQP1COHTD
20 - 2-11ADHAQP1COHTE
V
V
V
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
10% Glycerol
Page 1694
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
GAVAGE
99999-77
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
(NOT DEFINED)
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 125 mg/kg
04 - 125 mg/kg
05 - 250 mg.kg
06 - 250 mg/kg
07 - 500 mg/kg
08 - 500 mg/kg
09 - 1000 mg/kg
10 - 1000 mg/kg
11 - 2000 mg/kg
12 - 2000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1695
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99999-98
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprague Dawley (NCTR)
(NOT DEFINED)
CS
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
08 - F1 Veh. Ctrl M
09 - F1 Veh. Ctrl F
10 - F1 2.5 BPA M
11 - F1 2.5 BPA F
12 - F1 25.0 BPA M
13 - F1 25.0 BPA F
14 - F1 250.0 BPA M
15 - F1 250.0 BPA F
16 - F1 2500.BPA M
17 - F1 2500.BPA F
18 - F1 25000 BPA M
19 - F1 25000 BPA F
20 - F1 0.05 EE2 M
21 - F1 0.05 EE2 F
22 - F1 0.50 EE2 M
23 - F1 0.50 EE2 F
24 - F1 Veh. StDose M
25 - F1 Veh. StDose F
26 - F1 2.5 StDose M
27 - F1 2.5 StDose F
28 - F1 25.0 StDose M
29 - F1 25.0 StDose F
30 - F1 250.0StDose M
31 - F1 250.0StDose F
32 - F1 2500.StDose M
33 - F1 2500.StDose F
34 - F1 25000StDose M
35 - F1 25000StDose F
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.3% Carboxymethylcellulose
Page 1696
Training Compound (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
GAVAGE
99999-99
C99999
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, Sprague Dawley (NCTR)
(NOT DEFINED)
NR
123-4-56
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
08 - F1 Veh. Ctrl M
09 - F1 Veh. Ctrl F
10 - F1 2.5 BPA M
11 - F1 2.5 BPA F
12 - F1 25.0 BPA M
13 - F1 25.0 BPA F
14 - F1 250.0 BPA M
15 - F1 250.0 BPA F
16 - F1 2500.BPA M
17 - F1 2500.BPA F
18 - F1 25000 BPA M
19 - F1 25000 BPA F
20 - F1 0.05 EE2 M
21 - F1 0.05 EE2 F
22 - F1 0.50 EE2 M
23 - F1 0.50 EE2 F
24 - F1 Veh. StDose M
25 - F1 Veh. StDose F
26 - F1 2.5 StDose M
27 - F1 2.5 StDose F
28 - F1 25.0 StDose M
29 - F1 25.0 StDose F
30 - F1 250.0StDose M
31 - F1 250.0StDose F
32 - F1 2500.StDose M
33 - F1 2500.StDose F
34 - F1 25000StDose M
35 - F1 25000StDose F
V
V
T
T
T
T
T
T
T
T
T
T
T
T
T
T
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
M
F
0.3% Carboxymethylcellulose
Page 1697
Urethane
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
00602-01
C00602B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/21/1991
MA
51-79-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 110 PPM
04 - 110 PPM
05 - 330 PPM
06 - 330 PPM
07 - 1100 PPM
08 - 1100 PPM
09 - 3300 PPM
10 - 3300 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1698
Urethane (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
00602-02
C00602B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/10/1990
MA
51-79-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 110 PPM
04 - 110 PPM
05 - 330 PPM
06 - 330 PPM
07 - 1100 PPM
08 - 1100 PPM
09 - 3300 PPM
10 - 3300 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1699
Urethane + ethanol (combination)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
00602-03
C00602C
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/23/1991
MA
URETHCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 110 PPM
04 - 110 PPM
05 - 330 PPM
06 - 330 PPM
07 - 1100 PPM
08 - 1100 PPM
09 - 3300 PPM
10 - 3300 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL: WATER (5 : 95)
Page 1700
Urethane + ethanol (combination) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
00602-04
C00602C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/12/1990
MA
URETHCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 PPM
02 - 0 PPM
03 - 110 PPM
04 - 110 PPM
05 - 330 PPM
06 - 330 PPM
07 - 1100 PPM
08 - 1100 PPM
09 - 3300 PPM
10 - 3300 PPM
11 - 10000 PPM
12 - 10000 PPM
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL: WATER (5 : 95)
Page 1701
Urethane + ethanol (combination) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
00602-05
C00602F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
02/02/1997
NR
URETHCOMB
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0% ETH/ 0PPM URE
02 - 0% ETH/ 10PPMURE
03 - 0% ETH/ 30PPMURE
04 - 0% ETH/ 90PPMURE
05 - 2.5%ETH/0PPM URE
06 - 2.5%ETH/10PPMURE
07 - 2.5%ETH/30PPMURE
08 - 2.5%ETH/90PPMURE
09 - 5.0%ETH/0PPM URE
10 - 5.0%ETH/10PPMURE
11 - 5.0%ETH/30PPMURE
12 - 5.0%ETH/90PPMURE
13 - 0% ETH/ 0PPM URE
14 - 0% ETH/ 10PPMURE
15 - 0% ETH/ 30PPMURE
16 - 0% ETH/ 90PPMURE
17 - 2.5%ETH/0PPM URE
18 - 2.5%ETH/10PPMURE
19 - 2.5%ETH/30PPMURE
20 - 2.5%ETH/90PPMURE
21 - 5.0%ETH/0PPM URE
22 - 5.0%ETH/10PPMURE
23 - 5.0%ETH/30PPMURE
24 - 5.0%ETH/90PPMURE
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
V
T
T
T
M
M
M
M
M
M
M
M
M
M
M
M
F
F
F
F
F
F
F
F
F
F
F
F
WATER
Page 1702
Usnea Lichen
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20702-01
C20702
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
02/14/2009
NR
USNEALICHEN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control 0 PPM
02 - USNEA 30 PPM
03 - USNEA 60 PPM
04 - USNEA 120 PPM
05 - USNEA 360 PPM
06 - USNEA 720 PPM
07 - Control 0 PPM
08 - USNEA 30 PPM
09 - USNEA 60 PPM
10 - USNEA 120 PPM
11 - USNEA 360 PPM
12 - USNEA 720 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-41 (Irradiated)
Page 1703
Usnea Lichen (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20702-02
C20702
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
02/13/2009
NR
USNEALICHEN
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control 0 PPM
02 - USNEA 15 PPM
03 - USNEA 30 PPM
04 - USNEA 60 PPM
05 - USNEA 180 PPM
06 - USNEA 360 PPM
07 - Control 0 PPM
08 - USNEA 15 PPM
09 - USNEA 30 PPM
10 - USNEA 60 PPM
11 - USNEA 180 PPM
12 - USNEA 360 PPM
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-41 (Irradiated)
Page 1704
(+)-Usnic Acid
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20609-01
C20609
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/NCTR
08/07/2008
NR
7562-61-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control 0 ppm
02 - Usnic 30 ppm
03 - Usnic 60 ppm
04 - Usnic 120 ppm
05 - Usnic 360 ppm
06 - Usnic 720 ppm
07 - Control 0 ppm
08 - Usnic 30 ppm
09 - Usnic 60 ppm
10 - Usnic 120 ppm
11 - Usnic 360 ppm
12 - Usnic 720 ppm
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-41 (Irradiated)
Page 1705
(+)-Usnic Acid (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
FEED
20609-02
C20609
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1/NCTR
08/07/2008
NR
7562-61-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control 0 ppm
02 - Usnic 15 ppm
03 - Usnic 30 ppm
04 - Usnic 60 ppm
05 - Usnic 180 ppm
06 - Usnic 360 ppm
07 - Control 0 ppm
08 - Usnic 15 ppm
09 - Usnic 30 ppm
10 - Usnic 60 ppm
11 - Usnic 180 ppm
12 - Usnic 360 ppm
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
NIH-41 (Irradiated)
Page 1706
Vanadium pentoxide
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
61427-03
C61427
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/18/1990
TR
1314-62-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 1.00 MG/M3
03 - 2.00 MG/M3
04 - 4.00 MG/M3
05 - 8.00 MG/M3
06 - 16.00 MG/M3
07 - CONTROL
08 - 1.00 MG/M3
09 - 2.00 MG/M3
10 - 4.00 MG/M3
11 - 8.00 MG/M3
12 - 16.00 MG/M3
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 1707
Vanadium pentoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
61427-04
C61427
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/20/1990
TR
1314-62-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 1.00 MG/M3
03 - 2.00 MG/M3
04 - 4.00 MG/M3
05 - 8.00 MG/M3
06 - 16.00 MG/M3
07 - CONTROL
08 - 1.00 MG/M3
09 - 2.00 MG/M3
10 - 4.00 MG/M3
11 - 8.00 MG/M3
12 - 16.00 MG/M3
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
AIR
Page 1708
Vanadium pentoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
61427-07
C61427B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
01/06/1997
BN
1314-62-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 0.5 MG/M3
04 - 0.5 MG/M3
05 - 1.0 MG/M3
06 - 1.0 MG/M3
07 - 2.0 MG/M3
08 - 2.0 MG/M3
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1709
Vanadium pentoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
61427-08
C61427B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
01/13/1997
BN
1314-62-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 1.0 MG/M3
04 - 1.0 MG/M3
05 - 2.0 MG/M3
06 - 2.0 MG/M3
07 - 4.0 MG/M3
08 - 4.0 MG/M3
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1710
Vincamine
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
GAVAGE
20610-02
C20610
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/04/2011
BC
1617-90-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 0 mg/kg
03 - 62.5 mg/kg
04 - 62.5 mg/kg
05 - 125 mg/kg
06 - 125 mg/kg
07 - 250 mg/kg
08 - 250 mg/kg
09 - 500 mg/kg
10 - 500 mg/kg
11 - 1000 mg/kg
12 - 1000 mg/kg
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1711
Vincamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
20610-96
C20610
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/16/2011
BC
1617-90-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg F.Pup
02 - 10 mg/kg F.Pup
03 - 30 mg/kg F.Pup
04 - 100 mg/kg F.Pup
05 - 300 mg/kg F.Pup
V
T
T
T
T
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1712
Vincamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
20610-97
C20610
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/16/2011
BC
1617-90-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg MalePup
02 - 10 mg/kg MalePup
03 - 30 mg/kg MalePup
04 - 100mg/kg MalePup
05 - 300mg/kg MalePup
V
T
T
T
T
M
M
M
M
M
0.5 % AQUEOUS METHYLCELLULOSE
Page 1713
Vincamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
20610-98
C20610
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
05/16/2011
BC
1617-90-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg DamLac
02 - 10 mg/kg DamLac
03 - 30 mg/kg DamLac
04 - 100 mg/kg DamLac
05 - 300 mg/kg DamLac
V
T
T
T
T
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1714
Vincamine (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
PERINATAL EXPOS
GAVAGE
20610-99
C20610
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
04/24/2011
BC
1617-90-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg DamGes
02 - 10 mg/kg DamGes
03 - 30 mg/kg DamGes
04 - 100 mg/kg DamGes
05 - 300 mg/kg DamGes
V
T
T
T
T
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1715
4-Vinyl-1-cyclohexene diepoxide
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05044-01
C60139A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/04/1982
BC
106-87-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/ML
02 - 0 MG/ML
03 - 50 MG/ML
04 - 50 MG/ML
05 - 100 MG/ML
06 - 100 MG/ML
V
V
T
T
T
T
M
F
M
F
M
F
ACETONE
Page 1716
4-Vinyl-1-cyclohexene diepoxide (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
DERM SOL
05044-02
C60139A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/27/1982
BC
106-87-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/ML
02 - 0 MG/ML
03 - 25 MG/ML
04 - 25 MG/ML
05 - 50 MG/ML
06 - 50 MG/ML
07 - 100 MG/ ML
08 - 100 MG/ ML
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1717
Vinylidene Chloride
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20303-01
C20303
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/14/2004
BN
75-35-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400PPM
12 - 400 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1718
Vinylidene Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
RESP BDY
20303-02
C20303
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/14/2004
BN
75-35-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 25 PPM
04 - 25 PPM
05 - 50 PPM
06 - 50 PPM
07 - 100 PPM
08 - 100 PPM
09 - 200 PPM
10 - 200 PPM
11 - 400 PPM
12 - 400 PPM
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1719
Vinylidene Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20303-03
C20303
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/11/2004
BN
75-35-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 6.25 ppm
04 - 6.25 ppm
05 - 12.5 ppm
06 - 12.5 ppm
07 - 25 ppm
08 - 25 ppm
09 - 50 ppm
10 - 50 ppm
11 - 100 ppm
12 - 100 ppm
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
AIR
Page 1720
Vinylidene Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
RESP BDY
20303-04
C20303
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/11/2004
BN
75-35-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - CONTROL
03 - 6.25 PPM
04 - 6.25 PPM
05 - 12.5 PPM
06 - 12.5 PPM
07 - 25 PPM
08 - 25 PPM
09 - 50 PPM
10 - 50 PPM
11 - 100 PPM
V
V
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
F
AIR
Page 1721
Vinylidene Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20303-05
C20303
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
06/06/2005
BN
75-35-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 25 ppm
04 - 25 ppm
05 - 50 ppm
06 - 50 ppm
07 - 100 ppm
08 - 100 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1722
Vinylidene Chloride (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
20303-06
C20303
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
06/20/2005
BN
75-35-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control
02 - Control
03 - 6.25 ppm
04 - 6.25 ppm
05 - 12.5 ppm
06 - 12.5 ppm
07 - 25 ppm
08 - 25 ppm
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
AIR
Page 1723
Vinyl toluene
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05070-01
C56406
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/01/1981
MW
25013-15-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 300 PPM
03 - 100 PPM
04 - CONTROL
05 - 300 PPM
06 - 100 PPM
U
T
T
U
T
T
F
F
F
M
M
M
AIR
Page 1724
Vinyl toluene (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05070-02
C56406
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/01/1981
MW
25013-15-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 25 PPM
03 - 10 PPM
04 - CONTROL
05 - 25 PPM
06 - 10 PPM
U
T
T
U
T
T
F
F
F
M
M
M
AIR
Page 1725
Water disinfection byproducts (Bromochloroacetic acid)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96019-01
C96019
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
07/31/2000
SO
5589-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1726
Water disinfection byproducts (Bromochloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96019-02
C96019
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/02/2000
SO
5589-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1727
Water disinfection byproducts (Bromochloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96019-03
C96019
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
10/24/2000
SO
5589-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1728
Water disinfection byproducts (Bromochloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96019-04
C96019
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/22/2000
SO
5589-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1729
Water disinfection byproducts (Bromochloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96019-05
C96019
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/26/2001
SO
5589-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 250 MG/L
04 - 250 MG/L
05 - 500 MG/L
06 - 500 MG/L
07 - 1000 MG/L
08 - 1000 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1730
Water disinfection byproducts (Bromochloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96019-06
C96019
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
10/10/2001
SO
5589-96-8
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 250 MG/L
04 - 250 MG/L
05 - 500 MG/L
06 - 500 MG/L
07 - 1000 MG/L
08 - 1000 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1731
Water disinfection byproducts (Bromodichloroacetic Acid)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96014-01
C96014
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/21/2000
SO
71133-14-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1732
Water disinfection byproducts (Bromodichloroacetic Acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96014-02
C96014
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/23/2000
SO
71133-14-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1733
Water disinfection byproducts (Bromodichloroacetic Acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96014-03
C96014
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/14/2000
SO
71133-14-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1734
Water disinfection byproducts (Bromodichloroacetic Acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96014-04
C96014
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/12/2000
SO
71133-14-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 62.5 MG/L
04 - 62.5 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1735
Water disinfection byproducts (Bromodichloroacetic Acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96014-05
C96014B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F344/N Tac
10/26/2006
BC
71133-14-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/L
02 - 0 mg/L
03 - 250 mg/L
04 - 250 mg/L
05 - 500 mg/L
06 - 500 mg/L
07 - 1000 mg/L
08 - 1000 mg/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1736
Water disinfection byproducts (Bromodichloroacetic Acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96014-06
C96014B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/25/2006
BC
71133-14-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/L
02 - 0 mg/L
03 - 250 mg/L
04 - 250 mg/L
05 - 500 mg/L
06 - 500 mg/L
07 - 1000 mg/L
08 - 1000 mg/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1737
Water disinfection byproducts (Bromodichloromethane)
TEST:
ROUTE:
TDMS #:
NTP #:
21-DAY
WATER
96018-01
C96018
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
08/07/1998
SO
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 43.7 MG/L
03 - 87.5 MG/L
04 - 175 MG/L
05 - 350 MG/L
06 - 700 MG/L
U
T
T
T
T
T
M
M
M
M
M
M
TAP WATER
Page 1738
Water disinfection byproducts (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
21-DAY
WATER
96018-02
C96018
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/06/1998
SO
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 43.7 MG/L
03 - 87.5 MG/L
04 - 175 MG/L
05 - 350 MG/L
06 - 700 MG/L
U
T
T
T
T
T
F
F
F
F
F
F
TAP WATER
Page 1739
Water disinfection byproducts (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96018-03
C96018
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/15/1998
SO
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 175 MG/L
03 - 350 MG/L
04 - 700 MG/L
V
T
T
T
M
M
M
M
TAP WATER
Page 1740
Water disinfection byproducts (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96018-04
C96018
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/15/1998
SO
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 175 MG/L
03 - 350 MG/L
04 - 700 MG/L
U
T
T
T
F
F
F
F
TAP WATER
Page 1741
Water disinfection byproducts (Dibromoacetic acid)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96017-01
C96017
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/25/1998
SO
631-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 125 MG/L
04 - 125 MG/L
05 - 250 MG/L
06 - 250 MG/L
07 - 500 MG/L
08 - 500 MG/L
09 - 1000 MG/L
10 - 1000 MG/L
11 - 2000 MG/L
12 - 2000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1742
Water disinfection byproducts (Dibromoacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96017-02
C96017
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
11/24/1998
SO
631-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 125 MG/L
04 - 125 MG/L
05 - 250 MG/L
06 - 250 MG/L
07 - 500 MG/L
08 - 500 MG/L
09 - 1000 MG/L
10 - 1000 MG/L
11 - 2000 MG/L
12 - 2000 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1743
Water disinfection byproducts (Dibromoacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96017-03
C96017
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
02/15/1999
SO
631-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 125 MG/L
03 - 250 MG/L
04 - 500 MG/L
05 - 1000 MG/L
06 - 2000 MG/L
07 - 0 MG/L
08 - 125 MG/L
09 - 250 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 2000 MG/L
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
TAP WATER
Page 1744
Water disinfection byproducts (Dibromoacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96017-04
C96017
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/17/1999
SO
631-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 125 MG/L
03 - 250 MG/L
04 - 500 MG/L
05 - 1000 MG/L
06 - 2000 MG/L
07 - 0 MG/L
08 - 125 MG/L
09 - 250 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 2000 MG/L
V
T
T
T
T
T
V
T
T
T
T
T
M
M
M
M
M
M
F
F
F
F
F
F
TAP WATER
Page 1745
Water disinfection byproducts (Dibromoacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96017-05
C96017
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/08/2000
SO
631-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 50 MG/L
03 - 500 MG/L
04 - 1000 MG/L
05 - 0 MG/L
06 - 50 MG/L
07 - 500 MG/L
08 - 1000 MG/L
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
TAP WATER
Page 1746
Water disinfection byproducts (Dibromoacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96017-06
C96017
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
02/23/2000
SO
631-64-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 50 MG/L
03 - 500 MG/L
04 - 1000 MG/L
05 - 0 MG/L
06 - 50 MG/L
07 - 500 MG/L
08 - 1000 MG/L
V
T
T
T
V
T
T
T
M
M
M
M
F
F
F
F
TAP WATER
Page 1747
Water disinfection byproducts (Dibromoacetonitrile)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96015-01
C96015
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/25/2000
SO
3252-43-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 12.5 MG/L
04 - 12.5 MG/L
05 - 25 MG/L
06 - 25 MG/L
07 - 50 MG/L
08 - 50 MG/L
09 - 100 MG/L
10 - 100 MG/L
11 - 200 MG/L
12 - 200 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1748
Water disinfection byproducts (Dibromoacetonitrile) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
WATER
96015-02
C96015
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/26/2000
SO
3252-43-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 12.5 MG/L
04 - 12.5 MG/L
05 - 25 MG/L
06 - 25 MG/L
07 - 50 MG/L
08 - 50 MG/L
09 - 100 MG/L
10 - 100 MG/L
11 - 200 MG/L
12 - 200 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1749
Water disinfection byproducts (Dibromoacetonitrile) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96015-03
C96015
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
12/19/2000
SO
3252-43-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 12.5 MG/L
04 - 12.5 MG/L
05 - 25 MG/L
06 - 25 MG/L
07 - 50 MG/L
08 - 50 MG/L
09 - 100 MG/L
10 - 100 MG/L
11 - 200 MG/L
12 - 200 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1750
Water disinfection byproducts (Dibromoacetonitrile) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96015-04
C96015
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
12/17/2000
SO
3252-43-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 12.5 MG/L
04 - 12.5 MG/L
05 - 25 MG/L
06 - 25 MG/L
07 - 50 MG/L
08 - 50 MG/L
09 - 100 MG/L
10 - 100 MG/L
11 - 200 MG/L
12 - 200 MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1751
Water disinfection byproducts (Dibromoacetonitrile) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96015-05
C96015
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/05/2001
SO
3252-43-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1752
Water disinfection byproducts (Dibromoacetonitrile) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96015-06
C96015
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
08/22/2001
SO
3252-43-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 50 MG/L
04 - 50 MG/L
05 - 100 MG/L
06 - 100 MG/L
07 - 200 MG/L
08 - 200 MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1753
Water disinfection byproducts (Dichloroacetic acid)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96016-01
C96016
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
03/14/2000
SO
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 67 MG/L
04 - 67 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1754
Water disinfection byproducts (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
90-DAY
WATER
96016-02
C96016
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
03/12/2000
SO
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 67 MG/L
04 - 67 MG/L
05 - 125 MG/L
06 - 125 MG/L
07 - 250 MG/L
08 - 250 MG/L
09 - 500 MG/L
10 - 500 MG/L
11 - 1000 MG/L
12 - 1000 MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1755
Water disinfection byproducts (Sodium chlorate)
TEST:
ROUTE:
TDMS #:
NTP #:
21-DAY
WATER
96010-01
C96010A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/18/1998
SO
7775-09-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 125 MG/L
04 - 125 MG/L
05 - 250 MG/L
06 - 250 MG/L
07 - 500 MG/L
08 - 500 MG/L
09 - 1000MG/L
10 - 1000MG/L
11 - 2000MG/L
12 - 2000MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1756
Water disinfection byproducts (Sodium chlorate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
21-DAY
WATER
96010-02
C96010A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/20/1998
SO
7775-09-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 125 MG/L
04 - 125 MG/L
05 - 250 MG/L
06 - 250 MG/L
07 - 500 MG/L
08 - 500 MG/L
09 - 1000MG/L
10 - 1000MG/L
11 - 2000MG/L
12 - 2000MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1757
Water disinfection byproducts (Sodium chlorate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96010-03
C96010A
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
09/16/1998
SO
7775-09-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 125 MG/L
04 - 125 MG/L
05 - 1000MG/L
06 - 1000MG/L
07 - 2000MG/L
08 - 2000MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1758
Water disinfection byproducts (Sodium chlorate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
WATER
96010-04
C96010A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/30/1998
SO
7775-09-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 500 MG/L
04 - 500 MG/L
05 - 1000MG/L
06 - 1000MG/L
07 - 2000MG/L
08 - 2000MG/L
U
U
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1759
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
TEST:
ROUTE:
TDMS #:
NTP #:
21-DAY
WATER
96010-98
C96010
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/20/1998
SO
7775-09-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 125 MG/L
04 - 125 MG/L
05 - 250 MG/L
06 - 250 MG/L
07 - 500 MG/L
08 - 500 MG/L
09 - 1000MG/L
10 - 1000MG/L
11 - 2000MG/L
12 - 2000MG/L
U
U
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1760
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
21-DAY
WATER
96010-99
C96010
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
05/18/1998
SO
7775-09-9
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 125 MG/L
04 - 125 MG/L
05 - 250 MG/L
06 - 250 MG/L
07 - 500 MG/L
08 - 500 MG/L
09 - 1000MG/L
10 - 1000MG/L
11 - 2000MG/L
12 - 2000MG/L
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1761
Water disinfection model (Bromodichloromethane)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97013-01
C97013F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
05/12/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 16 MG/KG
04 - 16 MG/KG
05 - 32 MG/KG
06 - 32 MG/KG
07 - 64 MG/KG
08 - 64 MG/KG
09 - 128 MG/KG
10 - 128 MG/KG
11 - 256 MG/KG
12 - 256 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1762
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
97013-04
C97013E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
08/31/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 175 MG/L
04 - 175 MG/L
05 - 350 MG/L
06 - 350 MG/L
07 - 700 MG/L
08 - 700 MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1763
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
97013-05
C97013E
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/30/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 175 MG/L
04 - 175 MG/L
05 - 350 MG/L
06 - 350 MG/L
07 - 700 MG/L
08 - 700 MG/L
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1764
ACETONE
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97013-06
C97013F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/19/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 64 MG/KG
04 - 64 MG/KG
05 - 128 MG/KG
06 - 128 MG/KG
07 - 256 MG/KG
08 - 256 MG/KG
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1765
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97013-07
C97013G
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/16/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1766
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
GAVAGE
97013-08
C97013G
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
09/15/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
CORN OIL
Page 1767
ACETONE
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
WATER
97013-95
C97013J
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/30/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 175 MG/L
04 - 175 MG/L
05 - 350 MG/L
06 - 350 MG/L
07 - 700 MG/L
08 - 700 MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1768
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
WATER
97013-96
C97013J
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
08/31/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 175 MG/L
04 - 175 MG/L
05 - 350 MG/L
06 - 350 MG/L
07 - 700 MG/L
08 - 700 MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1769
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
97013-97
C97013K
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
09/15/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1770
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
GAVAGE
97013-98
C97013K
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/16/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 25 MG/KG
04 - 25 MG/KG
05 - 50 MG/KG
06 - 50 MG/KG
07 - 100 MG/KG
08 - 100 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
CORN OIL
Page 1771
Water disinfection model (Bromodichloromethane) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97013-99
C97013F
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
08/19/1999
BC
75-27-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 64 MG/KG
04 - 64 MG/KG
05 - 128 MG/KG
06 - 128 MG/KG
07 - 256 MG/KG
08 - 256 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE
Page 1772
Water disinfection model (Dichloroacetic acid)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97013-02
C97013D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
05/24/1999
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 31.25 MG/KG
04 - 31.25 MG/KG
05 - 62.5 MG/KG
06 - 62.5 MG/KG
07 - 125 MG/KG
08 - 125 MG/KG
09 - 250 MG/KG
10 - 250 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE
Page 1773
Water disinfection model (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97013-12
C97013D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
11/01/1999
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 31.25 MG/KG
04 - 31.25 MG/KG
05 - 62.5 MG/KG
06 - 62.5 MG/KG
07 - 125 MG/KG
08 - 125 MG/KG
09 - 250 MG/KG
10 - 250 MG/KG
11 - 500 MG/KG
12 - 500 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ACETONE : WATER (2 : 1)
Page 1774
Water disinfection model (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
97013-13
C97013C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
01/17/2000
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 500 MG/L
04 - 500 MG/L
05 - 1000MG/L
06 - 1000MG/L
07 - 2000MG/L
08 - 2000MG/L
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1775
ACETONE
Water disinfection model (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
97013-14
C97013C
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
01/18/2000
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 500 MG/L
04 - 500 MG/L
05 - 1000MG/L
06 - 1000MG/L
07 - 2000MG/L
08 - 2000MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1776
Water disinfection model (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97013-15
C97013D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/17/2000
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 31.25 MG/KG
04 - 31.25 MG/KG
05 - 125MG/KG
06 - 125MG/KG
07 - 500MG/KG
08 - 500MG/KG
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
ACETONE : WATER (2 : 1)
Page 1777
ACETONE
Water disinfection model (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
SKIN
97013-89
C97013D
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
02/17/2000
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 31.25 MG/KG
04 - 31.25 MG/KG
05 - 125MG/KG
06 - 125MG/KG
07 - 500MG/KG
08 - 500MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ACETONE : WATER (2 : 1)
Page 1778
Water disinfection model (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
WATER
97013-90
C97013I
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
01/18/2000
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 500 MG/L
04 - 500 MG/L
05 - 1000MG/L
06 - 1000MG/L
07 - 2000MG/L
08 - 2000MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1779
Water disinfection model (Dichloroacetic acid) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
WATER
97013-91
C97013I
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
01/17/2000
BC
79-43-6
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 500 MG/L
04 - 500 MG/L
05 - 1000MG/L
06 - 1000MG/L
07 - 2000MG/L
08 - 2000MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1780
Water disinfection model (Sodium bromate)
TEST:
ROUTE:
TDMS #:
NTP #:
14-DAY
SKIN
97013-03
C97013B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, FVB/N
07/12/1999
BC
7789-38-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 16 MG/KG
04 - 16 MG/KG
05 - 32 MG/KG
06 - 32 MG/KG
07 - 64 MG/KG
08 - 64 MG/KG
09 - 128 MG/KG
10 - 128 MG/KG
11 - 256 MG/KG
12 - 256 MG/KG
V
V
T
T
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
M
F
ETHANOL : WATER (2 : 3)
Page 1781
Water disinfection model (Sodium bromate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
97013-09
C97013A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
09/28/1999
BC
7789-38-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 80 MG/L
04 - 80 MG/L
05 - 400 MG/L
06 - 400 MG/L
07 - 800 MG/L
08 - 800 MG/L
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
TAP WATER
Page 1782
ACETONE
Water disinfection model (Sodium bromate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
WATER
97013-10
C97013A
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/29/1999
BC
7789-38-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 80 MG/L
04 - 80 MG/L
05 - 400 MG/L
06 - 400 MG/L
07 - 800 MG/L
08 - 800 MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1783
Water disinfection model (Sodium bromate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-WEEK
SKIN
97013-11
C97013B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
10/29/1999
BC
7789-38-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 64 MG/KG
04 - 64 MG/KG
05 - 128 MG/KG
06 - 128 MG/KG
07 - 256 MG/KG
08 - 256 MG/KG
09 - TPA
10 - TPA
V
V
T
T
T
T
T
T
P
P
M
F
M
F
M
F
M
F
M
F
ETHANOL : WATER (2 : 3)
Page 1784
ACETONE
Water disinfection model (Sodium bromate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
SKIN
97013-92
C97013B
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
10/29/1999
BC
7789-38-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/KG
02 - 0 MG/KG
03 - 64 MG/KG
04 - 64 MG/KG
05 - 128 MG/KG
06 - 128 MG/KG
07 - 256 MG/KG
08 - 256 MG/KG
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
ETHANOL : WATER (2 : 3)
Page 1785
Water disinfection model (Sodium bromate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
WATER
97013-93
C97013H
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, P53(C57BL/6)
09/29/1999
BC
7789-38-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 80 MG/L
04 - 80 MG/L
05 - 400 MG/L
06 - 400 MG/L
07 - 800 MG/L
08 - 800 MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1786
Water disinfection model (Sodium bromate) (continued)
TEST:
ROUTE:
TDMS #:
NTP #:
26-39 WEEKS
WATER
97013-94
C97013H
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, TG.AC HEMI
09/28/1999
BC
7789-38-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 MG/L
02 - 0 MG/L
03 - 80 MG/L
04 - 80 MG/L
05 - 400 MG/L
06 - 400 MG/L
07 - 800 MG/L
08 - 800 MG/L
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
TAP WATER
Page 1787
Wollastonite calcium silicates
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
RESP BDY
05083-01
C55470B
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, F 344/N
11/29/1982
NS
13983-17-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - CONTROL
02 - 10 MG/M3 24 MO
03 - 10 MG/M3 12 MO
04 - 10 MG/M3ASBESTOS
V
T
T
T
M
M
M
M
AIR
Page 1788
Wyeth 14,643 (WY)
TEST:
ROUTE:
TDMS #:
NTP #:
28-DAY
GAVAGE
91069-01
C91069
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
01/26/2012
BC
50892-23-4
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0mg/kg/d M
02 - 0mg/kg/d F
03 - 6.25mg/kg/d M
04 - 6.25mg/kg/d F
05 - 12.5mg/kg/d M
06 - 12.5mg/kg/d F
07 - 25mg/kg/d M
08 - 25mg/kg/d F
V
V
T
T
T
T
T
T
M
F
M
F
M
F
M
F
DEIONIZED WATER
Page 1789
Zinc Carbonate, Basic
TEST:
ROUTE:
TDMS #:
NTP #:
CHRONIC
FEED
20403-01
C20403
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, HSD
09/03/2009
BC
5263-02-5
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Control (38ppm)
02 - Control (38ppm)
03 - 3.5ppm SevZnDef
04 - 3.5ppm SevZnDef
05 - 7ppm ZnDef
06 - 7ppm ZnDef
07 - 250ppmModZnExc
08 - 250ppmModZnExc
09 - 500ppm ZnExc
10 - 500ppm ZnExc
V
V
T
T
T
T
T
T
T
T
M
F
M
F
M
F
M
F
M
F
AIN-93M Zinc Deficient
Page 1790
Black cohosh
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
00058-99
IM00058
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
04/27/2010
VC
84776-26-1
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 62.5 mg/kg
03 - 125 mg/kg
04 - 250 mg/kg
05 - 500 mg/kg
06 - 1000 mg/kg
07 - CPS 50 mg/kg
V
T
T
T
T
T
P
F
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1791
trans-Resveratrol
TEST:
ROUTE:
TDMS #:
NTP #:
150-DAY
GAVAGE
01090-99
I01090
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, NOD/MrkTac
06/01/2010
VC
501-36-0
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 125 mk/kg
03 - 250 mg/kg
04 - 500 mg/kg
05 - 1000 mg/kg
06 - 2000 mg/kg
V
T
T
T
T
T
F
F
F
F
F
F
0.5 % AQUEOUS METHYLCELLULOSE
Page 1792
sodium tungstate dihydrate
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
WATER
03038-99
IM03038
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
05/18/2009
VC
10213-10-2
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 125 mg/l
03 - 250 mg/l
04 - 500 mg/l
05 - 1000 mg/l
06 - 2000 mg/l
07 - CPS Positive Con
V
T
T
T
T
T
P
F
F
F
F
F
F
F
TAP WATER
Page 1793
2,3 butanedione
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
RESP BDY
20606-99
I20606
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, BALB/C
05/27/2008
VC
431-03-08
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Air Control
02 - DA 25-ppm
03 - DA 50-ppm
04 - DA 100-ppm
V
T
T
T
F
F
F
F
AIR
Page 1794
1,2:5,6 Dibenzanthracene
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
SUBCUT
20607-99
IM20607
SPECIES:
1ST DOSE:
LAB:
CAS:
MICE, B6C3F1
09/21/2006
VC
53-70-3
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - 0 mg/kg
02 - 250 ug/kg
03 - 793 ug/kg
04 - 2500 ug/kg
05 - CPS 50 mg/kg
V
T
T
T
P
F
F
F
F
F
CORN OIL
Page 1795
PHOSPHATE BUFFERED SALINE
3,3',4,4' - Tetracholoroazobenzene
TEST:
ROUTE:
TDMS #:
NTP #:
18-33 DAYS
GAVAGE
88486-99
IM88486
SPECIES:
1ST DOSE:
LAB:
CAS:
RATS, SD
10/21/2008
VC
14047-09-7
TREATMENT GROUP
ROLE
SEX
VEHICLE(S)
01 - Vehicle
02 - 0.1 mg/kg
03 - 0.5 mg/kg
04 - 1.0 mg/kg
05 - 5.0 mg/kg
06 - 10 mg/kg
07 - CPS Pos Cont
V
T
T
T
T
T
P
F
F
F
F
F
F
F
CORN OIL : ACETONE (99 : 1)
Page 1796
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