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Historical Control Survival for Skin Application/Ethanol Studies Male Rats/F344/N 4 studies - - - Lower 95% Confidence Umll (Lower Une) - - - Smvlval Probabillty [Middle Una) - - - Upper 95% Confidence Umlt [Upper Une) 1.0 0.9 ~~ CZJ '"'" 0 ~ ~ ~ 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0.0 0 15 30 45 60 75 90 105 120 90 105 120 WEEKS ON STUDY Female Rats/F344/N 4 studies W 0.9 ~~ CZJ 0 '"'" ~ ~ ~ ~ 0.8 0.7 0.6 0.5 0.4 0.3 0.2 0.1 0.0 0 15 30 45 60 75 WEEKS ON STUDY