TDMS No. Date Report Reqsted: WITH AVERAGE SEVERITY GRADES[b]

TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
F1 Mice
C Number:
C96011
Lock Date:
12/30/2003
Cage Range:
ALL
Date Range:
ALL
Reasons For Removal:
25021 TSAC
Removal Date Range:
ALL
Treatment Groups:
Include ALL
25020 NATD
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
25019 MSAC
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE MALE
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
250 PPM
500 PPM
1000 PPM
50
50
50
50
7
5
9
7
13
7
20
7
38
50
34
50
30
50
23
50
Disposition Summary
Animals Initially in Study
Early Deaths
Moribund Sacrifice
Natural Death
Survivors
Terminal Sacrifice
Animals Examined Microscopically
ALIMENTARY SYSTEM
Gallbladder
Degeneration, Hyaline
Hyperplasia
Intestine Large, Cecum
Infiltration Cellular, Histiocyte
Inflammation, Acute
Intestine Large, Colon
Intestine Small, Duodenum
Intestine Small, Ileum
Necrosis
Peyer's Patch, Inflammation, Acute
Intestine Small, Jejunum
Peyer's Patch, Hyperplasia
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Hepatodiaphragmatic Nodule
Inflammation, Granulomatous
Mixed Cell Focus
Necrosis
Tension Lipidosis
Centrilobular, Necrosis
Mesentery
Thrombosis
(43)
1 [3.0]
1 [3.0]
(49)
(32)
(37)
(38)
(47)
(44)
(50)
(49)
(49)
(46)
(44)
(46)
(45)
(43)
(43)
1 [1.0]
(44)
1 [2.0]
1 [3.0]
(48)
(44)
(44)
(46)
1 [4.0]
(50)
3 [2.0]
5
11
5
(43)
(44)
(50)
1 [2.0]
4
20
16
(50)
1 [3.0]
(48)
(50)
1 [2.0]
7
24 [2.0]
6
1 [2.0]
2
2 [1.0]
1 [2.0]
1 [1.0]
(3)
1 [2.0]
3
4 [2.5]
1 [3.0]
4 [2.8]
(7)
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 2
5
11
14
1
1 [1.0]
1
4 [3.0]
2 [2.0]
1
1 [3.0]
(6)
(3)
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE MALE
Fat, Necrosis
Pancreas
Atrophy
Duct, Cyst
Stomach, Forestomach
Inflammation
Ulcer
Epithelium, Erosion
Epithelium, Hyperplasia
Stomach, Glandular
Mineralization
Necrosis
Tongue
Tooth
Malformation
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
250 PPM
3 [2.0]
(50)
6 [2.2]
(50)
1 [1.0]
6 [2.0]
(49)
3 [2.0]
(49)
(50)
1 [2.0]
6 [2.8]
8 [2.3]
(48)
(49)
5 [2.0]
6 [2.8]
1 [4.0]
13 [2.1]
(48)
(1)
(15)
14 [1.9]
(50)
2 [2.0]
4 [2.8]
1 [4.0]
7 [2.1]
(48)
1 [1.0]
2 [1.5]
(0)
(8)
7 [1.4]
(0)
(8)
8 [1.4]
1 [1.0]
(0)
(6)
6 [1.8]
(50)
10 [1.2]
(50)
18 [1.1]
(50)
13 [1.2]
1 [4.0]
(50)
1 [3.0]
2 [2.0]
(50)
500 PPM
1000 PPM
CARDIOVASCULAR SYSTEM
Heart
Cardiomyopathy
Inflammation, Acute
Mineralization
Necrosis
Thrombosis
Artery, Inflammation, Chronic Active
1 [1.0]
1 [4.0]
1 [2.0]
1 [3.0]
1 [2.0]
(50)
17 [1.1]
2 [2.0]
1 [1.0]
1 [3.0]
2 [3.5]
1 [3.0]
ENDOCRINE SYSTEM
Adrenal Cortex
Atrophy
Degeneration
Hyperplasia
Hypertrophy
Adrenal Medulla
Hyperplasia
Islets, Pancreatic
Hyperplasia
Hypertrophy
Pituitary Gland
(50)
(50)
14 [2.1]
29 [1.9]
(50)
2 [2.0]
(50)
1 [3.0]
1 [3.0]
15 [2.3]
16 [1.8]
(50)
1 [2.0]
(50)
3 [2.7]
(48)
(49)
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 3
(49)
(50)
1 [3.0]
12 [1.8]
14 [1.9]
(48)
8 [2.1]
9 [1.9]
(50)
(49)
1 [4.0]
1 [2.0]
(49)
(49)
(49)
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE MALE
Pars Distalis, Hyperplasia
Thyroid Gland
Follicular Cell, Hyperplasia
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
250 PPM
500 PPM
1000 PPM
1 [1.0]
(50)
7 [1.9]
1 [2.0]
(50)
7 [2.4]
3 [2.3]
(49)
7 [1.7]
1 [2.0]
(50)
11 [1.9]
(50)
(50)
1 [2.0]
2 [1.0]
(50)
1 [4.0]
(49)
(50)
(50)
1 [3.0]
(49)
(48)
GENERAL BODY SYSTEM
None
GENITAL SYSTEM
Epididymis
Angiectasis
Granuloma Sperm
Preputial Gland
Ectasia
Inflammation, Chronic Active
Prostate
Angiectasis
Hyperplasia
Infiltration Cellular, Polymorphonuclear
Artery, Inflammation, Chronic Active
Testes
Atrophy
(49)
1 [4.0]
(50)
1 [2.0]
1 [3.0]
1 [3.0]
(50)
5 [2.4]
1 [4.0]
(50)
(49)
1 [2.0]
1 [3.0]
(50)
3 [2.0]
(49)
1 [3.0]
(50)
1 [2.0]
(50)
1 [2.0]
(0)
(49)
(49)
(1)
1 [3.0]
(45)
(22)
(2)
HEMATOPOIETIC SYSTEM
Bone Marrow
Thrombosis
Lymph Node
Iliac, Infiltration Cellular, Mixed Cell
Lymph Node, Bronchial
Lymph Node, Mandibular
Infiltration Cellular, Plasma Cell
Lymph Node, Mediastinal
Lymph Node, Mesenteric
Infiltration Cellular, Mixed Cell
Infiltration Cellular, Plasma Cell
Spleen
(50)
(0)
(45)
(34)
1 [4.0]
(37)
(48)
1 [4.0]
(50)
(41)
(35)
(42)
(47)
(40)
(46)
1 [4.0]
1 [4.0]
(49)
(50)
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 4
(35)
(25)
(39)
(44)
(50)
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE MALE
Hematopoietic Cell Proliferation
Infiltration Cellular, Plasma Cell
Thymus
Artery, Inflammation
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
250 PPM
500 PPM
1000 PPM
3 [2.7]
1 [4.0]
(45)
1 [3.0]
2 [3.0]
(44)
(38)
1 [3.0]
(44)
(50)
(50)
1
(49)
(50)
1 [4.0]
2 [3.0]
6 [4.0]
(50)
1 [2.0]
(0)
(50)
(50)
(50)
(0)
(1)
(0)
(50)
(50)
1 [3.0]
(50)
(50)
INTEGUMENTARY SYSTEM
Skin
Cyst Epithelial Inclusion
Inflammation, Acute
Inflammation, Chronic Active
Ulcer
Epidermis, Abscess
1 [4.0]
3 [3.3]
1 [2.0]
1 [1.0]
MUSCULOSKELETAL SYSTEM
Bone
Hyperostosis
Skeletal Muscle
NERVOUS SYSTEM
Brain
Degeneration
Gliosis
Necrosis
Ventricle, Infiltration Cellular,
Polymorphonuclear
1 [2.0]
1 [2.0]
1 [3.0]
RESPIRATORY SYSTEM
Larynx
Metaplasia, Squamous
Lung
Thrombosis
Alveolar Epithelium, Bronchiole,
Metaplasia
Alveolar Epithelium, Hyperplasia
(50)
(49)
(50)
(50)
5 [1.4]
(50)
1 [2.0]
43 [2.9]
(50)
1 [4.0]
42 [3.1]
3 [1.0]
3 [1.7]
4 [1.3]
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 5
(50)
1 [2.0]
(50)
1 [2.0]
39 [3.0]
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE MALE
Alveolus, Infiltration Cellular, Histiocyte
Bronchiole, Hyperplasia
Bronchus, Inflammation, Acute
Bronchus, Necrosis
Nose
Inflammation, Suppurative
Polyp, Inflammatory
Glands, Olfactory Epithelium,
Hyperplasia
Olfactory Epithelium, Accumulation,
Hyaline Droplet
Olfactory Epithelium, Atrophy
Olfactory Epithelium, Hyperplasia,
Atypical
Olfactory Epithelium, Hyperplasia, Basal
Cell
Respiratory Epithelium, Accumulation,
Hyaline Droplet
Respiratory Epithelium, Metaplasia,
Squamous
Vomeronasal Organ, Inflammation,
Suppurative
Pleura
Trachea
Necrosis
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
2 [1.5]
(50)
2 [2.0]
1
3 [1.0]
250 PPM
500 PPM
3 [2.7]
11 [2.1]
17 [3.2]
1 [4.0]
1000 PPM
1 [4.0]
18 [2.8]
(50)
2 [1.5]
(49)
9 [1.1]
1 [3.0]
(48)
6 [1.5]
11 [1.0]
9 [1.1]
23 [1.0]
13 [1.1]
11 [1.2]
5 [1.6]
38 [1.4]
11 [1.7]
15 [1.0]
33 [1.1]
1 [1.0]
5 [1.4]
1 [2.0]
4 [1.3]
1 [2.0]
1 [1.0]
1 [1.0]
1 [1.0]
(0)
(50)
(0)
(50)
(0)
(49)
(2)
(50)
1 [4.0]
(49)
1 [4.0]
(50)
1 [2.0]
2 [2.5]
(49)
1 [4.0]
(50)
2 [2.5]
(49)
1 [1.0]
(48)
1 [4.0]
4 [1.8]
1 [1.0]
(50)
1 [2.0]
1 [2.0]
SPECIAL SENSES SYSTEM
Eye
Cataract
Cornea, Inflammation, Chronic Active
Cornea, Mineralization
Harderian Gland
Hyperplasia
Hypertrophy
Inflammation, Chronic
Necrosis
(48)
2 [2.0]
1 [2.0]
1 [3.0]
URINARY SYSTEM
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 6
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE MALE
Kidney
Infarct
Inflammation, Suppurative
Metaplasia, Osseous
Mineralization
Nephropathy
Artery, Inflammation, Chronic Active
Capsule, Fibrosis
Perirenal Tissue, Thrombosis
Renal Tubule, Cyst
Renal Tubule, Hyperplasia
Renal Tubule, Necrosis
Renal Tubule, Pigmentation
Urinary Bladder
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
250 PPM
500 PPM
(50)
1 [2.0]
(50)
4 [2.0]
(50)
3 [2.0]
3 [1.3]
1 [1.0]
47 [1.6]
1 [2.0]
1 [2.0]
1 [1.0]
44 [1.4]
45 [1.6]
1000 PPM
(50)
7 [2.4]
1 [2.0]
1 [1.0]
2 [1.0]
41 [1.2]
1 [3.0]
1 [1.0]
1 [4.0]
1
1 [2.0]
2 [2.0]
(50)
(48)
(49)
*** END OF MALE ***
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 7
1 [2.0]
1 [2.0]
(48)
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE FEMALE
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
125 PPM
250 PPM
500 PPM
50
50
50
50
8
5
10
4
8
3
12
3
37
50
36
50
39
50
1
34
50
Disposition Summary
Animals Initially in Study
Early Deaths
Moribund Sacrifice
Natural Death
Survivors
Natural Death
Terminal Sacrifice
Animals Examined Microscopically
ALIMENTARY SYSTEM
Esophagus
Gallbladder
Intestine Large, Cecum
Intestine Large, Colon
Intestine Small, Duodenum
Necrosis
Intestine Small, Ileum
Intestine Small, Jejunum
Hyperplasia, Lymphoid
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Cyst
Eosinophilic Focus
Erythrophagocytosis
Fatty Change
Hematopoietic Cell Proliferation
Inflammation, Granulomatous
Mixed Cell Focus
Necrosis
Tension Lipidosis
Centrilobular, Necrosis
Mesentery
Inflammation, Chronic Active
(50)
(38)
(46)
(47)
(46)
1 [2.0]
(46)
(46)
(50)
(41)
(47)
(50)
(47)
(50)
(44)
(49)
(50)
(49)
(50)
(37)
(47)
(48)
(48)
(47)
(47)
(47)
(47)
(50)
(50)
1 [2.0]
3
6
(49)
(49)
1 [3.0]
(50)
1 [1.0]
4
1
11 [2.0]
7
3
4
1 [3.0]
8
(50)
1
5
1 [3.0]
14
1 [3.0]
1 [4.0]
1 [1.0]
1 [2.0]
4 [3.0]
3 [1.7]
2 [3.0]
(11)
1
3 [3.3]
3 [1.7]
1 [2.0]
(12)
3 [2.3]
4 [1.5]
(11)
1 [3.0]
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 8
1
2 [1.0]
4 [1.5]
1 [3.0]
(9)
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE FEMALE
Fat, Hemorrhage
Fat, Necrosis
Pancreas
Atrophy
Inflammation, Chronic Active
Salivary Glands
Stomach, Forestomach
Hemorrhage
Inflammation
Ulcer
Epithelium, Erosion
Epithelium, Hyperplasia
Stomach, Glandular
Mineralization
Necrosis
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
125 PPM
11 [2.1]
(49)
1 [4.0]
10 [2.4]
(50)
1 [3.0]
(50)
(49)
(50)
(50)
250 PPM
500 PPM
10 [2.1]
(50)
1 [3.0]
9 [2.0]
(50)
3 [3.3]
(50)
(50)
1 [2.0]
(50)
(50)
1 [3.0]
2 [3.5]
1 [1.0]
3 [1.0]
(49)
1 [2.0]
1 [2.0]
(49)
2 [2.0]
(50)
2 [2.0]
(50)
1 [2.0]
1 [2.0]
1 [2.0]
CARDIOVASCULAR SYSTEM
Heart
Cardiomyopathy
Inflammation, Chronic
Mineralization
Thrombosis
(50)
12 [1.0]
(50)
17 [1.2]
1 [1.0]
1 [2.0]
(50)
6 [1.2]
1 [2.0]
1 [2.0]
(50)
7 [1.0]
(50)
7 [2.0]
1 [1.0]
(50)
2 [3.0]
(50)
2 [3.0]
(50)
7 [2.0]
10 [2.2]
(50)
16 [2.6]
(49)
5 [2.2]
6 [1.5]
(49)
2 [2.5]
(50)
3 [2.0]
(48)
1 [1.0]
6 [2.5]
(50)
10 [2.0]
ENDOCRINE SYSTEM
Adrenal Cortex
Hyperplasia
Hypertrophy
Adrenal Medulla
Hyperplasia
Islets, Pancreatic
Hyperplasia
Pituitary Gland
Pars Distalis, Angiectasis
Pars Distalis, Hyperplasia
Thyroid Gland
Follicular Cell, Hyperplasia
(50)
5 [1.8]
2 [1.5]
(50)
1 [2.0]
(49)
1 [4.0]
(50)
3 [1.7]
11 [2.5]
(50)
15 [2.0]
(50)
7 [2.3]
1 [1.0]
(49)
4 [2.5]
(50)
1 [2.0]
(49)
1 [1.0]
19 [2.7]
(50)
10 [2.3]
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 9
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE FEMALE
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
125 PPM
250 PPM
500 PPM
GENERAL BODY SYSTEM
None
GENITAL SYSTEM
Ovary
Angiectasis
Cyst
Thrombosis
Uterus
Angiectasis
Decidual Reaction
Inflammation, Suppurative
Thrombosis
Endometrium, Hyperplasia, Cystic
(48)
1 [4.0]
9 [2.2]
1 [4.0]
(50)
1 [4.0]
1 [4.0]
1 [3.0]
1 [4.0]
8 [3.1]
(50)
(50)
(49)
12 [2.4]
1 [4.0]
(50)
2 [2.5]
14 [2.5]
(50)
1 [3.0]
11 [3.0]
1 [4.0]
(50)
3 [3.0]
11 [3.5]
18 [3.6]
1 [3.0]
2 [2.5]
8 [3.6]
(50)
(9)
1 [2.0]
1 [3.0]
1 [3.0]
2 [2.5]
(50)
(5)
(50)
(5)
1 [3.0]
1 [4.0]
(36)
(42)
(40)
(38)
(46)
(42)
(40)
(42)
(46)
(50)
6 [3.0]
(48)
(50)
2 [3.0]
(50)
(48)
(40)
1 [4.0]
(48)
(50)
2 [2.5]
1 [3.0]
(48)
2 [2.5]
HEMATOPOIETIC SYSTEM
Bone Marrow
Lymph Node
Iliac, Ectasia
Lumbar, Angiectasis
Lumbar, Ectasia
Lumbar, Hyperplasia, Lymphoid
Renal, Ectasia
Lymph Node, Bronchial
Lymph Node, Mandibular
Inflammation, Granulomatous
Lymph Node, Mediastinal
Hyperplasia, Lymphoid
Lymph Node, Mesenteric
Spleen
Hematopoietic Cell Proliferation
Hyperplasia, Lymphoid
Thymus
(49)
(4)
1 [3.0]
2 [3.5]
1 [3.0]
(39)
(35)
1 [4.0]
(44)
(46)
(49)
1 [2.0]
1 [2.0]
(49)
INTEGUMENTARY SYSTEM
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 10
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE FEMALE
Mammary Gland
Hyperplasia
Skin
Inflammation, Chronic Active
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
(50)
1 [2.0]
(50)
125 PPM
250 PPM
500 PPM
(50)
(50)
(50)
1 [2.0]
(50)
(50)
1 [4.0]
(50)
1 [4.0]
(50)
(1)
(50)
(1)
(50)
(1)
(50)
(0)
(50)
(50)
(50)
1 [2.0]
(50)
MUSCULOSKELETAL SYSTEM
Bone
Skeletal Muscle
NERVOUS SYSTEM
Brain
Necrosis
Meninges, Infiltration Cellular,
Mononuclear Cell
1 [2.0]
RESPIRATORY SYSTEM
Larynx
Inflammation, Suppurative
Metaplasia, Squamous
Lung
Foreign Body
Hemorrhage
Inflammation, Suppurative
Thrombosis
Alveolar Epithelium, Bronchiole,
Hyperplasia
Alveolar Epithelium, Bronchiole,
Metaplasia
Alveolar Epithelium, Hyperplasia
Alveolar Epithelium, Metaplasia,
Squamous
Alveolus, Infiltration Cellular, Histiocyte
Bronchiole, Hyperplasia
Nose
Inflammation, Suppurative
(50)
(49)
(50)
(50)
1 [3.0]
1 [2.0]
(50)
(50)
(50)
(50)
1
2 [2.5]
1 [1.0]
2 [2.0]
1 [3.0]
2 [1.0]
1 [1.0]
(50)
42 [2.6]
49 [2.9]
47 [3.3]
3 [1.3]
6 [1.3]
6 [3.2]
1 [1.0]
17 [2.7]
(50)
1 [1.0]
1 [4.0]
10 [2.8]
(50)
3 [1.3]
3 [4.0]
14 [2.8]
(50)
7 [1.3]
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 11
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE FEMALE
Glands, Olfactory Epithelium, Cyst
Glands, Olfactory Epithelium,
Hyperplasia
Olfactory Epithelium, Atrophy
Olfactory Epithelium, Hyperplasia,
Atypical
Olfactory Epithelium, Hyperplasia, Basal
Cell
Olfactory Epithelium, Necrosis
Respiratory Epithelium, Accumulation,
Hyaline Droplet
Respiratory Epithelium, Metaplasia,
Squamous
Respiratory Epithelium, Necrosis
Turbinate, Necrosis
Pleura
Trachea
Inflammation, Suppurative
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
125 PPM
1 [1.0]
4 [1.0]
4 [1.0]
250 PPM
500 PPM
1
4 [1.0]
11 [1.0]
11 [1.1]
9 [1.1]
2 [1.0]
18 [1.2]
10 [1.2]
1 [1.0]
11 [1.0]
25 [1.1]
2 [1.0]
1 [1.0]
2 [1.0]
1 [2.0]
3 [1.3]
1 [2.0]
6 [1.2]
1 [2.0]
(0)
(50)
(1)
(50)
(1)
(50)
(49)
2 [2.5]
(50)
(50)
1 [1.0]
2 [2.0]
(2)
(50)
2 [2.5]
SPECIAL SENSES SYSTEM
Eye
Cataract
Degeneration
Cornea, Epithelium, Hyperplasia
Cornea, Inflammation, Acute
Cornea, Inflammation, Chronic Active
Cornea, Mineralization
Harderian Gland
Atrophy
Hyperplasia
1 [3.0]
4 [3.3]
(49)
2 [2.5]
1 [4.0]
1 [1.0]
1 [2.0]
1 [1.0]
1 [2.0]
(49)
(50)
2 [2.5]
1 [1.0]
(50)
2 [3.0]
1 [2.0]
1 [2.0]
(50)
(50)
1 [3.0]
(50)
1 [2.0]
3 [2.3]
2 [2.0]
1 [2.0]
1 [1.0]
2 [1.0]
3 [1.0]
1 [2.0]
(50)
1 [1.0]
6 [2.0]
URINARY SYSTEM
Kidney
Cyst
Infarct
Inflammation, Suppurative
Metaplasia, Osseous
(49)
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 12
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW
TDMS No. 96011 - 06
Test Type: CHRONIC
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: MICE/B6C3F1
B6C3F1 MICE FEMALE
Nephropathy
Capsule, Fibrosis
Renal Tubule, Karyomegaly
Renal Tubule, Necrosis
Urinary Bladder
Inflammation, Chronic Active
Artery, Inflammation, Chronic Active
P18: INCIDENCE RATES OF NON-NEOPLASTIC LESIONS BY ANATOMIC SITE (a)
WITH AVERAGE SEVERITY GRADES[b]
CUMENE
CAS Number: 98-82-8
Pathologist: PIERCE, J. - GRUMBEIN, S.
CONTROL
36 [1.2]
1 [1.0]
1 [3.0]
3 [2.7]
(48)
125 PPM
250 PPM
34 [1.2]
34 [1.3]
1 [2.0]
1 [2.0]
(48)
(49)
1 [4.0]
1 [3.0]
*** END OF REPORT ***
a - Number of animals examined microscopically at site and number of animals with lesion
b - Average severity grade (1-minimal; 2-mild; 3-moderate; 4-marked)
Page 13
500 PPM
34 [1.2]
1 [3.0]
(48)
Date Report Reqsted: 02/27/2006
Time Report Reqsted: 15:28:27
First Dose M/F: 06/11/01 / 06/11/01
Lab: BNW