Metal working fluids (CIMSTAR 3800)

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Metal working fluids (CIMSTAR 3800)

Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
F1_Rev.1_RE
NTP Study Number:
C20515
Lock Date:
01/12/2011
Cage Range:
ALL
Date Range:
ALL
Reasons For Removal:
ALL
Removal Date Range:
ALL
Treatment Groups:
Include ALL
Study Gender:
Both
TDMSE Version:
3.0.1.1_001
PWG Approval Date:
02/21/2013
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
8
0
7
1
5
0
7
0
4
0
7
3
0
0
5
9
7
0
7
3
0
0
7
2
9
0
5
3
5
0
7
1
0
0
7
3
0
0
3
4
5
0
7
3
0
0
6
1
2
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
0
4
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
0
0
0
1
0
0
0
0
2
0
0
0
0
3
0
0
0
0
4
0
0
0
0
5
0
0
0
0
6
0
0
0
0
7
0
0
0
0
8
0
0
0
0
9
0
0
0
1
0
0
0
0
1
1
0
0
0
1
2
0
0
0
1
3
0
0
0
1
4
0
0
0
1
5
0
0
0
1
6
0
0
0
1
7
0
0
0
1
8
0
0
0
1
9
0
0
0
2
0
0
0
0
2
1
0
0
0
2
2
0
0
0
2
3
0
0
0
2
4
0
0
0
2
5
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Rectum
+
+
+
+
I
+
+
+
+
I
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Mixed Cell Focus
Necrosis
Bile Duct, Cyst
Bile Duct, Dilatation
Bile Duct, Hyperplasia
Bile Duct, Inflammation, Chronic Active
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
males
(cont...)
ALIMENTARY SYSTEM
Mesentery
Fat, Necrosis
X
X
X
2
X
X
3
4
3
2
2
+
2
+
2
+
2
+
2
+
2
Oral Mucosa
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
8
0
7
1
5
0
7
0
4
0
7
3
0
0
5
9
7
0
7
3
0
0
7
2
9
0
5
3
5
0
7
1
0
0
7
3
0
0
3
4
5
0
7
3
0
0
6
1
2
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
0
4
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
0
0
0
1
0
0
0
0
2
0
0
0
0
3
0
0
0
0
4
0
0
0
0
5
0
0
0
0
6
0
0
0
0
7
0
0
0
0
8
0
0
0
0
9
0
0
0
1
0
0
0
0
1
1
0
0
0
1
2
0
0
0
1
3
0
0
0
1
4
0
0
0
1
5
0
0
0
1
6
0
0
0
1
7
0
0
0
1
8
0
0
0
1
9
0
0
0
2
0
0
0
0
2
1
0
0
0
2
2
0
0
0
2
3
0
0
0
2
4
0
0
0
2
5
Pancreas
Atrophy
Basophilic Focus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Hyperplasia, Squamous
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
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+
+
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Blood Vessel
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+
+
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+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
+
+
1
+
2
+
+
1
+
2
+
+
1
+
+
2
+
+
+
1
+
+
+
1
+
+
1
+
1
+
+
+
1
+
1
+
2
+
1
Adrenal Cortex
Accessory Adrenal Cortical Nodule
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
2
2
2
2
2
2
2
2
1
2
2
2
2
2
2
2
Adrenal Medulla
Hyperplasia
+
+
+
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
males
(cont...)
Developmental Malformation
X
X
CARDIOVASCULAR SYSTEM
ENDOCRINE SYSTEM
1
2
2
2
2
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 3
+
+
2
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
8
0
7
1
5
0
7
0
4
0
7
3
0
0
5
9
7
0
7
3
0
0
7
2
9
0
5
3
5
0
7
1
0
0
7
3
0
0
3
4
5
0
7
3
0
0
6
1
2
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
0
4
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
0
0
0
1
0
0
0
0
2
0
0
0
0
3
0
0
0
0
4
0
0
0
0
5
0
0
0
0
6
0
0
0
0
7
0
0
0
0
8
0
0
0
0
9
0
0
0
1
0
0
0
0
1
1
0
0
0
1
2
0
0
0
1
3
0
0
0
1
4
0
0
0
1
5
0
0
0
1
6
0
0
0
1
7
0
0
0
1
8
0
0
0
1
9
0
0
0
2
0
0
0
0
2
1
0
0
0
2
2
0
0
0
2
3
0
0
0
2
4
0
0
0
2
5
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Parathyroid Gland
Hyperplasia
+
M
+
+
+
+
M
+
+
+
+
+
+
+
1
+
+
M
+
+
M
+
+
M
M
+
Pituitary Gland
Cyst
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
2
2
2
3
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
2
+
2
+
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
2
1
males
(cont...)
2
+
1
+
+
+
1
+
+
+
3
+
2
1
+
1
+
+
4
+
2
+
1
+
+
1
+
+
1
+
1
+
1
+
1
+
1
+
1
1
GENERAL BODY SYSTEM
Peritoneum
GENITAL SYSTEM
Epididymis
Granuloma Sperm
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Preputial Gland
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
Prostate
Hyperplasia
Inflammation, Chronic Active
+
+
+
1
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
1
+
1
+
+
+
+
+
1
+
+
Seminal Vesicle
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 4
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
8
0
7
1
5
0
7
0
4
0
7
3
0
0
5
9
7
0
7
3
0
0
7
2
9
0
5
3
5
0
7
1
0
0
7
3
0
0
3
4
5
0
7
3
0
0
6
1
2
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
0
4
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
0
0
0
1
0
0
0
0
2
0
0
0
0
3
0
0
0
0
4
0
0
0
0
5
0
0
0
0
6
0
0
0
0
7
0
0
0
0
8
0
0
0
0
9
0
0
0
1
0
0
0
0
1
1
0
0
0
1
2
0
0
0
1
3
0
0
0
1
4
0
0
0
1
5
0
0
0
1
6
0
0
0
1
7
0
0
0
1
8
0
0
0
1
9
0
0
0
2
0
0
0
0
2
1
0
0
0
2
2
0
0
0
2
3
0
0
0
2
4
0
0
0
2
5
+
+
+
1
3
+
4
3
+
1
+
+
1
+
3
+
+
+
+
2
+
+
+
4
+
+
+
1
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
males
(cont...)
Hyperplasia
Testes
Atrophy
Edema
Necrosis
2
2
2
3
3
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
Lymph Node
Axillary, Infiltration Cellular, Plasma Cell
Iliac, Ectasia
Lumbar, Ectasia
Lumbar, Hemorrhage
Lumbar, Infiltration Cellular, Plasma Cell
Pancreatic, Ectasia
Pancreatic, Inflammation, Chronic Active
+
+
+
+
2
3
3
2
Lymph Node, Bronchial
+
+
M
+
+
M
+
+
+
M
+
M
+
+
+
+
+
+
+
M
+
+
+
+
M
Lymph Node, Mandibular
Ectasia
+
+
M
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
Lymph Node, Mediastinal
Ectasia
+
+
+
+
3
+
+
+
M
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Mesenteric
Ectasia
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
2
2
4
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 5
3
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
8
0
7
1
5
0
7
0
4
0
7
3
0
0
5
9
7
0
7
3
0
0
7
2
9
0
5
3
5
0
7
1
0
0
7
3
0
0
3
4
5
0
7
3
0
0
6
1
2
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
0
4
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
0
0
0
1
0
0
0
0
2
0
0
0
0
3
0
0
0
0
4
0
0
0
0
5
0
0
0
0
6
0
0
0
0
7
0
0
0
0
8
0
0
0
0
9
0
0
0
1
0
0
0
0
1
1
0
0
0
1
2
0
0
0
1
3
0
0
0
1
4
0
0
0
1
5
0
0
0
1
6
0
0
0
1
7
0
0
0
1
8
0
0
0
1
9
0
0
0
2
0
0
0
0
2
1
0
0
0
2
2
0
0
0
2
3
0
0
0
2
4
0
0
0
2
5
Infiltration Cellular, Plasma Cell
males
(cont...)
3
Spleen
Hematopoietic Cell Proliferation
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Thymus
Atrophy
+
+
+
+
+
+
+
I
I
M
+
4
+
+
+
+
+
+
+
+
+
+
+
M
I
I
Mammary Gland
Galactocele
M
M
+
M
M
M
M
+
M
M
M
M
M
M
M
+
M
M
M
M
M
M
M
M
M
Skin
Cyst Epithelial Inclusion
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
4
4
3
+
X
4
4
4
4
4
4
4
4
4
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
INTEGUMENTARY SYSTEM
4
MUSCULOSKELETAL SYSTEM
Bone
Hyperostosis
Skeletal Muscle
NERVOUS SYSTEM
Brain
Peripheral Nerve
+
+
+
Spinal Cord
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 6
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
8
0
7
1
5
0
7
0
4
0
7
3
0
0
5
9
7
0
7
3
0
0
7
2
9
0
5
3
5
0
7
1
0
0
7
3
0
0
3
4
5
0
7
3
0
0
6
1
2
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
0
4
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
0
0
0
1
0
0
0
0
2
0
0
0
0
3
0
0
0
0
4
0
0
0
0
5
0
0
0
0
6
0
0
0
0
7
0
0
0
0
8
0
0
0
0
9
0
0
0
1
0
0
0
0
1
1
0
0
0
1
2
0
0
0
1
3
0
0
0
1
4
0
0
0
1
5
0
0
0
1
6
0
0
0
1
7
0
0
0
1
8
0
0
0
1
9
0
0
0
2
0
0
0
0
2
1
0
0
0
2
2
0
0
0
2
3
0
0
0
2
4
0
0
0
2
5
Larynx
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lung
Foreign Body
Hemorrhage
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
1
Nose
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
+
Trachea
+
+
+
Eye
Cataract
Retina, Atrophy
+
+
Harderian Gland
Atrophy
Hyperplasia
Hypertrophy
+
+
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
males
(cont...)
RESPIRATORY SYSTEM
2
1
+
1
+
+
+
+
+
+
+
+
+
+
1
+
2
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
1
1
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
2
1
2
2
+
+
+
+
+
1
+
+
1
+
2
SPECIAL SENSES SYSTEM
1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 7
2
2
2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
8
0
7
1
5
0
7
0
4
0
7
3
0
0
5
9
7
0
7
3
0
0
7
2
9
0
5
3
5
0
7
1
0
0
7
3
0
0
3
4
5
0
7
3
0
0
6
1
2
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
0
4
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
0
0
0
1
0
0
0
0
2
0
0
0
0
3
0
0
0
0
4
0
0
0
0
5
0
0
0
0
6
0
0
0
0
7
0
0
0
0
8
0
0
0
0
9
0
0
0
1
0
0
0
0
1
1
0
0
0
1
2
0
0
0
1
3
0
0
0
1
4
0
0
0
1
5
0
0
0
1
6
0
0
0
1
7
0
0
0
1
8
0
0
0
1
9
0
0
0
2
0
0
0
0
2
1
0
0
0
2
2
0
0
0
2
3
0
0
0
2
4
0
0
0
2
5
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
1
2
2
1
2
2
4
1
1
2
2
2
2
1
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Zymbal's Gland
+
males
(cont...)
+
URINARY SYSTEM
Kidney
Cyst
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
3
2
2
1
Urinary Bladder
+
+
+
+
+
2
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 8
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
6
2
7
0
5
9
9
0
5
9
7
0
7
3
0
0
7
2
9
0
7
3
0
0
6
1
9
0
7
3
1
0
7
2
9
0
4
9
4
0
7
3
1
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
2
9
0
5
2
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
6
0
7
0
6
5
3
0
7
2
9
0
0
0
2
6
0
0
0
2
7
0
0
0
2
8
0
0
0
2
9
0
0
0
3
0
0
0
0
3
1
0
0
0
3
2
0
0
0
3
3
0
0
0
3
4
0
0
0
3
5
0
0
0
3
6
0
0
0
3
7
0
0
0
3
8
0
0
0
3
9
0
0
0
4
0
0
0
0
4
1
0
0
0
4
2
0
0
0
4
3
0
0
0
4
4
0
0
0
4
5
0
0
0
4
6
0
0
0
4
7
0
0
0
4
8
0
0
0
4
9
0
0
0
5
0
* TOTALS
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
48
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Mixed Cell Focus
Necrosis
Bile Duct, Cyst
Bile Duct, Dilatation
Bile Duct, Hyperplasia
Bile Duct, Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
50
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
ALIMENTARY SYSTEM
Mesentery
Fat, Necrosis
Oral Mucosa
X
X
X
X
X
X
X
X
X
X
X
X
X
X
3
11
29
3
2
1
3
1
1
X
X
X
3
+
2
+
2.0
2.5
3.3
2.0
2.0
7
6 2.0
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 9
1
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
6
2
7
0
5
9
9
0
5
9
7
0
7
3
0
0
7
2
9
0
7
3
0
0
6
1
9
0
7
3
1
0
7
2
9
0
4
9
4
0
7
3
1
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
2
9
0
5
2
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
6
0
7
0
6
5
3
0
7
2
9
0
0
0
2
6
0
0
0
2
7
0
0
0
2
8
0
0
0
2
9
0
0
0
3
0
0
0
0
3
1
0
0
0
3
2
0
0
0
3
3
0
0
0
3
4
0
0
0
3
5
0
0
0
3
6
0
0
0
3
7
0
0
0
3
8
0
0
0
3
9
0
0
0
4
0
0
0
0
4
1
0
0
0
4
2
0
0
0
4
3
0
0
0
4
4
0
0
0
4
5
0
0
0
4
6
0
0
0
4
7
0
0
0
4
8
0
0
0
4
9
0
0
0
5
0
Developmental Malformation
* TOTALS
X
+
+
+
+
+
+
+
1
Pancreas
Atrophy
Basophilic Focus
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Stomach, Forestomach
Hyperplasia, Squamous
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Stomach, Glandular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
+
+
+
1
+
+
1
+
1
+
+
1
+
1
+
+
1
+
+
1
+
+
1
+
+
2
+
+
1
+
2
+
2
+
1
+
+
1
+
50
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1 1.0
2
1 3.0
1 4.0
4
CARDIOVASCULAR SYSTEM
28 1.3
ENDOCRINE SYSTEM
Adrenal Cortex
Accessory Adrenal Cortical Nodule
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
Adrenal Medulla
Hyperplasia
+
+
2
2
2
+
+
+
+
+
+
2
2
2
2
2
+
2
+
+
2
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 10
2
2
2
+
+
2
+
2
2
+
+
+
2
+
+
2
2
2
2
2
2
+
+
+
1
2
+
+
50
1
2
26
20
2
2
+
3.0
1.0
2.0
2.0
50
2 2.0
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
6
2
7
0
5
9
9
0
5
9
7
0
7
3
0
0
7
2
9
0
7
3
0
0
6
1
9
0
7
3
1
0
7
2
9
0
4
9
4
0
7
3
1
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
2
9
0
5
2
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
6
0
7
0
6
5
3
0
7
2
9
0
0
0
2
6
0
0
0
2
7
0
0
0
2
8
0
0
0
2
9
0
0
0
3
0
0
0
0
3
1
0
0
0
3
2
0
0
0
3
3
0
0
0
3
4
0
0
0
3
5
0
0
0
3
6
0
0
0
3
7
0
0
0
3
8
0
0
0
3
9
0
0
0
4
0
0
0
0
4
1
0
0
0
4
2
0
0
0
4
3
0
0
0
4
4
0
0
0
4
5
0
0
0
4
6
0
0
0
4
7
0
0
0
4
8
0
0
0
4
9
0
0
0
5
0
* TOTALS
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Parathyroid Gland
Hyperplasia
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
43
Pituitary Gland
Cyst
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
1 1.0
+
+
2
2
+
+
M
+
2
+
+
+
2
+
+
+
+
2
+
+
+
2
1
2
+
+
+
+
2
+
2
+
+
1
+
1
+
2
+
1
+
+
1
2
+
1
+
+
1
+
3
+
1
+
1
+
1
+
+
2
+
2
+
+
+
+
49
1 2.0
14 1.9
3 2.3
3
+
1
3
+
1
+
2
+
2
+
+
50
34 1.4
5 2.0
GENERAL BODY SYSTEM
Peritoneum
+
1
GENITAL SYSTEM
Epididymis
Granuloma Sperm
+
+
Preputial Gland
Inflammation, Chronic Active
+
1
+
Prostate
Hyperplasia
Inflammation, Chronic Active
+
+
Seminal Vesicle
+
+
+
+
+
+
+
+
+
+
+
3
+
1
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
2 3.0
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
1
+
+
+
+
2
+
+
2
+
+
+
+
50
3 1.7
+
50
12 1.3
1 3.0
3
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 11
+
+
+
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
6
2
7
0
5
9
9
0
5
9
7
0
7
3
0
0
7
2
9
0
7
3
0
0
6
1
9
0
7
3
1
0
7
2
9
0
4
9
4
0
7
3
1
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
2
9
0
5
2
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
6
0
7
0
6
5
3
0
7
2
9
0
0
0
2
6
0
0
0
2
7
0
0
0
2
8
0
0
0
2
9
0
0
0
3
0
0
0
0
3
1
0
0
0
3
2
0
0
0
3
3
0
0
0
3
4
0
0
0
3
5
0
0
0
3
6
0
0
0
3
7
0
0
0
3
8
0
0
0
3
9
0
0
0
4
0
0
0
0
4
1
0
0
0
4
2
0
0
0
4
3
0
0
0
4
4
0
0
0
4
5
0
0
0
4
6
0
0
0
4
7
0
0
0
4
8
0
0
0
4
9
0
0
0
5
0
Hyperplasia
Testes
Atrophy
Edema
Necrosis
* TOTALS
2
+
+
+
+
4
3
+
3
+
+
+
3
2
+
4
+
+
+
+
+
+
+
+
+
+
+
3
3
+
+
+
2
2
2
+
+
+
+
+
+
1
+
+
2
1 2.0
+
+
3
+
1
+
50
15 2.5
16 2.3
1 3.0
2
HEMATOPOIETIC SYSTEM
Bone Marrow
+
Lymph Node
Axillary, Infiltration Cellular, Plasma Cell
Iliac, Ectasia
Lumbar, Ectasia
Lumbar, Hemorrhage
Lumbar, Infiltration Cellular, Plasma Cell
Pancreatic, Ectasia
Pancreatic, Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
12
1
2
2
1
5
1
1
4
3
3
4
Lymph Node, Bronchial
+
+
+
+
+
+
+
+
+
+
+
M
+
+
M
+
+
+
+
+
+
+
+
+
+
42
Lymph Node, Mandibular
Ectasia
+
M
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
46
Lymph Node, Mediastinal
Ectasia
+
Lymph Node, Mesenteric
Ectasia
+
1.0
2.5
3.0
2.0
3.0
3.0
4.0
1 3.0
+
M
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
46
1 3.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
2 1.5
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 12
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
6
2
7
0
5
9
9
0
5
9
7
0
7
3
0
0
7
2
9
0
7
3
0
0
6
1
9
0
7
3
1
0
7
2
9
0
4
9
4
0
7
3
1
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
2
9
0
5
2
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
6
0
7
0
6
5
3
0
7
2
9
0
0
0
2
6
0
0
0
2
7
0
0
0
2
8
0
0
0
2
9
0
0
0
3
0
0
0
0
3
1
0
0
0
3
2
0
0
0
3
3
0
0
0
3
4
0
0
0
3
5
0
0
0
3
6
0
0
0
3
7
0
0
0
3
8
0
0
0
3
9
0
0
0
4
0
0
0
0
4
1
0
0
0
4
2
0
0
0
4
3
0
0
0
4
4
0
0
0
4
5
0
0
0
4
6
0
0
0
4
7
0
0
0
4
8
0
0
0
4
9
0
0
0
5
0
* TOTALS
Infiltration Cellular, Plasma Cell
1 3.0
Spleen
Hematopoietic Cell Proliferation
+
Thymus
Atrophy
+
+
+
+
3
+
+
I
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
2 2.5
+
+
+
+
+
M
+
+
+
+
M
+
+
M
+
+
+
+
+
+
+
40
1 4.0
INTEGUMENTARY SYSTEM
Mammary Gland
Galactocele
+
1
M
+
M
Skin
Cyst Epithelial Inclusion
Inflammation, Chronic Active
+
+
+
+
4
3
4
+
+
+
+
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
6
1 1.0
+
+
+
3
3
+
+
+
+
+
+
+
+
4
4
4
3
4
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
2
4
4
3
+
+
+
+
+
+
+
50
1
31 3.7
3
MUSCULOSKELETAL SYSTEM
Bone
Hyperostosis
+
+
+
Skeletal Muscle
+
+
+
+
+
+
+
2
+
50
1 2.0
+
1
NERVOUS SYSTEM
Brain
+
+
+
+
+
+
+
+
+
+
+
Peripheral Nerve
+
+
5
Spinal Cord
+
+
5
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 13
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
6
2
7
0
5
9
9
0
5
9
7
0
7
3
0
0
7
2
9
0
7
3
0
0
6
1
9
0
7
3
1
0
7
2
9
0
4
9
4
0
7
3
1
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
2
9
0
5
2
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
6
0
7
0
6
5
3
0
7
2
9
0
0
0
2
6
0
0
0
2
7
0
0
0
2
8
0
0
0
2
9
0
0
0
3
0
0
0
0
3
1
0
0
0
3
2
0
0
0
3
3
0
0
0
3
4
0
0
0
3
5
0
0
0
3
6
0
0
0
3
7
0
0
0
3
8
0
0
0
3
9
0
0
0
4
0
0
0
0
4
1
0
0
0
4
2
0
0
0
4
3
0
0
0
4
4
0
0
0
4
5
0
0
0
4
6
0
0
0
4
7
0
0
0
4
8
0
0
0
4
9
0
0
0
5
0
* TOTALS
Larynx
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
50
Lung
Foreign Body
Hemorrhage
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
X
+
+
+
1
1
2
Nose
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
+
Trachea
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Eye
Cataract
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Harderian Gland
Atrophy
Hyperplasia
Hypertrophy
+
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
RESPIRATORY SYSTEM
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
2
2
+
+
+
+
50
1
1 2.0
6 1.2
4 1.3
1
1
+
1 2.0
+
+
+
+
3
1
+
+
2
+
+
1
+
+
+
+
+
+
1
+
+
2
+
+
50
4 1.0
1 1.0
19 1.6
1
1
1
2
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
2
3
+
+
+
50
+
+
2
SPECIAL SENSES SYSTEM
2
+
+
+
+
+
2
2
1
+
+
+
+
+
+
1
1
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 14
+
+
+
+
+
1
+
+
+
+
1
1
2 2.0
2 2.5
+
+
50
2
2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
1 2.0
17 1.5
2 2.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
6
2
7
0
5
9
9
0
5
9
7
0
7
3
0
0
7
2
9
0
7
3
0
0
6
1
9
0
7
3
1
0
7
2
9
0
4
9
4
0
7
3
1
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
2
9
0
5
2
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
6
0
7
0
6
5
3
0
7
2
9
0
0
0
2
6
0
0
0
2
7
0
0
0
2
8
0
0
0
2
9
0
0
0
3
0
0
0
0
3
1
0
0
0
3
2
0
0
0
3
3
0
0
0
3
4
0
0
0
3
5
0
0
0
3
6
0
0
0
3
7
0
0
0
3
8
0
0
0
3
9
0
0
0
4
0
0
0
0
4
1
0
0
0
4
2
0
0
0
4
3
0
0
0
4
4
0
0
0
4
5
0
0
0
4
6
0
0
0
4
7
0
0
0
4
8
0
0
0
4
9
0
0
0
5
0
Zymbal's Gland
+
* TOTALS
3
URINARY SYSTEM
Kidney
Cyst
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
1
1
1
1
2
1
Urinary Bladder
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
2
1
1
2
2
2
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 15
+
3
2
+
+
3
+
2
2
3
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
4
2
2
1
1
+
+
+
+
+
+
50
4 2.3
43 1.8
1 2.0
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
0
0
7
3
0
0
5
4
7
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
2
8
6
0
7
3
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
3
0
0
6
3
3
0
5
6
2
0
5
6
4
0
4
2
9
0
7
3
0
0
7
3
0
0
6
7
7
0
7
2
9
0
6
0
3
0
7
1
7
0
0
2
0
1
0
0
2
0
2
0
0
2
0
3
0
0
2
0
4
0
0
2
0
5
0
0
2
0
6
0
0
2
0
7
0
0
2
0
8
0
0
2
0
9
0
0
2
1
0
0
0
2
1
1
0
0
2
1
2
0
0
2
1
3
0
0
2
1
4
0
0
2
1
5
0
0
2
1
6
0
0
2
1
7
0
0
2
1
8
0
0
2
1
9
0
0
2
2
0
0
0
2
2
1
0
0
2
2
2
0
0
2
2
3
0
0
2
2
4
0
0
2
2
5
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
Inflammation, Acute
Necrosis
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
Intestine Large, Colon
Inflammation, Acute
Necrosis
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
I
+
+
+
+
A
+
+
+
+
+
+
Intestine Small, Duodenum
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
Intestine Small, Ileum
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
Intestine Small, Jejunum
Diverticulum
+
+
A
+
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Congestion
Inflammation, Granulomatous
Necrosis
Bile Duct, Cyst
Bile Duct, Dilatation
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
X
X
X
X
X
X
X
X
+
1
X
X
+
1
X
X
+
1
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
males
(cont...)
ALIMENTARY SYSTEM
4
X
X
X
X
X
X
2
X
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 16
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
0
0
7
3
0
0
5
4
7
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
2
8
6
0
7
3
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
3
0
0
6
3
3
0
5
6
2
0
5
6
4
0
4
2
9
0
7
3
0
0
7
3
0
0
6
7
7
0
7
2
9
0
6
0
3
0
7
1
7
0
0
2
0
1
0
0
2
0
2
0
0
2
0
3
0
0
2
0
4
0
0
2
0
5
0
0
2
0
6
0
0
2
0
7
0
0
2
0
8
0
0
2
0
9
0
0
2
1
0
0
0
2
1
1
0
0
2
1
2
0
0
2
1
3
0
0
2
1
4
0
0
2
1
5
0
0
2
1
6
0
0
2
1
7
0
0
2
1
8
0
0
2
1
9
0
0
2
2
0
0
0
2
2
1
0
0
2
2
2
0
0
2
2
3
0
0
2
2
4
0
0
2
2
5
Bile Duct, Hyperplasia
males
(cont...)
1
Mesentery
Fat, Necrosis
+
2
+
+
2
+
+
+
+
+
+
Pancreas
Atrophy
Basophilic Focus
Inflammation, Acute
+
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
X
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
1
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
X
+
+
2
X
Tooth
Inflammation, Chronic Active
+
4
CARDIOVASCULAR SYSTEM
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
+
2
+
+
1
+
2
+
1
+
1
+
1
+
+
2
+
2
+
1
+
1
+
+
1
+
1
+
+
+
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
ENDOCRINE SYSTEM
Adrenal Cortex
Degeneration, Cystic
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 17
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
0
0
7
3
0
0
5
4
7
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
2
8
6
0
7
3
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
3
0
0
6
3
3
0
5
6
2
0
5
6
4
0
4
2
9
0
7
3
0
0
7
3
0
0
6
7
7
0
7
2
9
0
6
0
3
0
7
1
7
0
0
2
0
1
0
0
2
0
2
0
0
2
0
3
0
0
2
0
4
0
0
2
0
5
0
0
2
0
6
0
0
2
0
7
0
0
2
0
8
0
0
2
0
9
0
0
2
1
0
0
0
2
1
1
0
0
2
1
2
0
0
2
1
3
0
0
2
1
4
0
0
2
1
5
0
0
2
1
6
0
0
2
1
7
0
0
2
1
8
0
0
2
1
9
0
0
2
2
0
0
0
2
2
1
0
0
2
2
2
0
0
2
2
3
0
0
2
2
4
0
0
2
2
5
2
2
2
2
2
2
2
2
2
2
2
2
1
2
2
2
Adrenal Medulla
Hyperplasia
+
+
+
+
+
2
+
+
+
+
+
+
+
I
+
+
+
+
+
+
+
+
+
+
+
+
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Parathyroid Gland
+
+
+
+
+
+
+
+
+
+
M
+
+
M
+
+
+
+
+
+
+
+
M
+
+
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
2
+
2
+
+
+
+
2
+
3
+
+
+
+
2
+
+
+
+
2
+
+
+
2
+
+
+
+
+
2
+
+
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
2
+
1
+
+
+
3
+
2
+
1
+
+
2
+
1
+
+
1
2
+
1
+
1
+
1
+
1
+
2
+
+
+
1
+
1
+
1
+
+
1
+
Epididymis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Preputial Gland
Inflammation, Chronic Active
+
+
+
3
+
2
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
Prostate
Hyperplasia
+
+
+
2
+
+
2
+
1
+
1
+
+
2
+
2
+
+
+
3
+
+
+
+
+
+
+
2
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
Hyperplasia
Hypertrophy
2
2
males
(cont...)
2
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 18
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
0
0
7
3
0
0
5
4
7
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
2
8
6
0
7
3
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
3
0
0
6
3
3
0
5
6
2
0
5
6
4
0
4
2
9
0
7
3
0
0
7
3
0
0
6
7
7
0
7
2
9
0
6
0
3
0
7
1
7
0
0
2
0
1
0
0
2
0
2
0
0
2
0
3
0
0
2
0
4
0
0
2
0
5
0
0
2
0
6
0
0
2
0
7
0
0
2
0
8
0
0
2
0
9
0
0
2
1
0
0
0
2
1
1
0
0
2
1
2
0
0
2
1
3
0
0
2
1
4
0
0
2
1
5
0
0
2
1
6
0
0
2
1
7
0
0
2
1
8
0
0
2
1
9
0
0
2
2
0
0
0
2
2
1
0
0
2
2
2
0
0
2
2
3
0
0
2
2
4
0
0
2
2
5
Inflammation, Chronic Active
males
(cont...)
3
Seminal Vesicle
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Testes
Atrophy
Edema
Artery, Inflammation, Chronic Active
+
4
3
+
+
+
2
+
+
1
+
+
+
+
+
+
+
+
1
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
2
2
2
2
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
Lymph Node
Lumbar, Ectasia
Lumbar, Infiltration Cellular, Plasma Cell
Renal, Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
2
3
Lymph Node, Bronchial
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Mandibular
Ectasia
Hyperplasia, Lymphoid
Infiltration Cellular, Plasma Cell
+
+
+
+
+
3
+
+
+
M
+
+
+
+
+
+
+
+
M
+
M
+
+
+
+
+
Lymph Node, Mediastinal
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Mesenteric
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Spleen
Inflammation, Granulomatous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 19
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
0
0
7
3
0
0
5
4
7
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
2
8
6
0
7
3
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
3
0
0
6
3
3
0
5
6
2
0
5
6
4
0
4
2
9
0
7
3
0
0
7
3
0
0
6
7
7
0
7
2
9
0
6
0
3
0
7
1
7
0
0
2
0
1
0
0
2
0
2
0
0
2
0
3
0
0
2
0
4
0
0
2
0
5
0
0
2
0
6
0
0
2
0
7
0
0
2
0
8
0
0
2
0
9
0
0
2
1
0
0
0
2
1
1
0
0
2
1
2
0
0
2
1
3
0
0
2
1
4
0
0
2
1
5
0
0
2
1
6
0
0
2
1
7
0
0
2
1
8
0
0
2
1
9
0
0
2
2
0
0
0
2
2
1
0
0
2
2
2
0
0
2
2
3
0
0
2
2
4
0
0
2
2
5
+
+
+
+
+
+
+
+
I
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
Mammary Gland
M
+
M
+
M
+
M
M
M
M
M
+
M
M
M
M
M
M
M
M
M
M
M
M
M
Skin
Cyst Epithelial Inclusion
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
4
3
4
4
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
Thymus
males
(cont...)
INTEGUMENTARY SYSTEM
4
4
4
3
4
3
MUSCULOSKELETAL SYSTEM
Bone
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
1
1
1
1
Skeletal Muscle
Necrosis
NERVOUS SYSTEM
Brain
Peripheral Nerve
+
+
Spinal Cord
+
+
RESPIRATORY SYSTEM
Larynx
Inflammation, Acute
Inflammation, Chronic Active
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
3
1
1
2
1
2
2
1
2
1
2
1
2
2
1
2
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 20
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
0
0
7
3
0
0
5
4
7
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
2
8
6
0
7
3
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
3
0
0
6
3
3
0
5
6
2
0
5
6
4
0
4
2
9
0
7
3
0
0
7
3
0
0
6
7
7
0
7
2
9
0
6
0
3
0
7
1
7
0
0
2
0
1
0
0
2
0
2
0
0
2
0
3
0
0
2
0
4
0
0
2
0
5
0
0
2
0
6
0
0
2
0
7
0
0
2
0
8
0
0
2
0
9
0
0
2
1
0
0
0
2
1
1
0
0
2
1
2
0
0
2
1
3
0
0
2
1
4
0
0
2
1
5
0
0
2
1
6
0
0
2
1
7
0
0
2
1
8
0
0
2
1
9
0
0
2
2
0
0
0
2
2
1
0
0
2
2
2
0
0
2
2
3
0
0
2
2
4
0
0
2
2
5
Lung
Inflammation, Lymphohistiocytic
Inflammation, Acute
Metaplasia, Squamous
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
+
+
1
+
+
+
+
1
+
+
+
+
1
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
1
Nose
Inflammation, Acute
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
+
2
1
3
1
1
3
2
1
4
2
2
3
2
Trachea
Inflammation, Acute
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Eye
Cataract
Cornea, Inflammation, Chronic Active
Retina, Atrophy
+
3
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
Harderian Gland
Hyperplasia
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
1
+
+
+
1
2
1
3
+
+
+
+
+
1
2
1
3
1
1
1
4
+
males
(cont...)
1
+
+
+
+
+
+
+
+
1
1
2
2
2
1
2
3
2
3
3
1
1
3
3
2
3
3
2
3
2
1
4
2
1
2
1
1
1
3
1
SPECIAL SENSES SYSTEM
3
+
1
+
+
+
2
+
1
+
1
+
+
+
+
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 21
3
+
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
0
0
7
3
0
0
5
4
7
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
2
8
6
0
7
3
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
3
0
0
6
3
3
0
5
6
2
0
5
6
4
0
4
2
9
0
7
3
0
0
7
3
0
0
6
7
7
0
7
2
9
0
6
0
3
0
7
1
7
0
0
2
0
1
0
0
2
0
2
0
0
2
0
3
0
0
2
0
4
0
0
2
0
5
0
0
2
0
6
0
0
2
0
7
0
0
2
0
8
0
0
2
0
9
0
0
2
1
0
0
0
2
1
1
0
0
2
1
2
0
0
2
1
3
0
0
2
1
4
0
0
2
1
5
0
0
2
1
6
0
0
2
1
7
0
0
2
1
8
0
0
2
1
9
0
0
2
2
0
0
0
2
2
1
0
0
2
2
2
0
0
2
2
3
0
0
2
2
4
0
0
2
2
5
Kidney
Cyst
Hydronephrosis
Inflammation, Suppurative
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
2
+
3
2
1
3
1
2
2
3
1
2
3
1
2
1
3
2
2
Urinary Bladder
Calculus Gross Observation
Inflammation, Chronic Active
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
males
(cont...)
Hypertrophy
Zymbal's Gland
URINARY SYSTEM
2
+
2
+
+
3
+
+
+
+
+
+
+
1
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 22
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
4
3
9
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
0
4
0
7
3
0
0
7
0
4
0
7
3
0
0
7
3
0
0
6
3
7
0
7
2
9
0
6
5
3
0
7
3
0
0
7
3
0
0
7
2
9
0
7
3
1
0
7
3
0
0
7
3
0
0
5
0
5
0
7
3
0
0
7
2
9
0
6
2
0
0
0
2
2
6
0
0
2
2
7
0
0
2
2
8
0
0
2
2
9
0
0
2
3
0
0
0
2
3
1
0
0
2
3
2
0
0
2
3
3
0
0
2
3
4
0
0
2
3
5
0
0
2
3
6
0
0
2
3
7
0
0
2
3
8
0
0
2
3
9
0
0
2
4
0
0
0
2
4
1
0
0
2
4
2
0
0
2
4
3
0
0
2
4
4
0
0
2
4
5
0
0
2
4
6
0
0
2
4
7
0
0
2
4
8
0
0
2
4
9
0
0
2
5
0
* TOTALS
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
Inflammation, Acute
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
2
3
+
+
+
+
+
+
+
+
+
+
+
+
48
Intestine Large, Colon
Inflammation, Acute
Necrosis
+
+
3
3
+
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
I
+
+
+
+
+
+
+
+
+
+
+
47
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
48
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
48
Intestine Small, Jejunum
Diverticulum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
48
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Congestion
Inflammation, Granulomatous
Necrosis
Bile Duct, Cyst
Bile Duct, Dilatation
+
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
ALIMENTARY SYSTEM
+
+
+
+
+
+
+
+
+
+
+
1 2.0
1 3.0
+
+
+
+
+
+
+
+
+
+
+
49
1 3.0
1 3.0
1 4.0
X
X
+
+
X
1
+
X
+
1
+
X
X
+
+
+
+
X
X
X
X
+
1
X
X
+
1
+
+
X
X
+
+
X
X
+
+
+
X
X
X
+
+
+
+
+
X
X
X
X
+
1
50
1
2
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 23
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
7
20
26
1
1
3
1
2
1.0
1.0
1.0
2.7
2.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
4
3
9
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
0
4
0
7
3
0
0
7
0
4
0
7
3
0
0
7
3
0
0
6
3
7
0
7
2
9
0
6
5
3
0
7
3
0
0
7
3
0
0
7
2
9
0
7
3
1
0
7
3
0
0
7
3
0
0
5
0
5
0
7
3
0
0
7
2
9
0
6
2
0
0
0
2
2
6
0
0
2
2
7
0
0
2
2
8
0
0
2
2
9
0
0
2
3
0
0
0
2
3
1
0
0
2
3
2
0
0
2
3
3
0
0
2
3
4
0
0
2
3
5
0
0
2
3
6
0
0
2
3
7
0
0
2
3
8
0
0
2
3
9
0
0
2
4
0
0
0
2
4
1
0
0
2
4
2
0
0
2
4
3
0
0
2
4
4
0
0
2
4
5
0
0
2
4
6
0
0
2
4
7
0
0
2
4
8
0
0
2
4
9
0
0
2
5
0
Bile Duct, Hyperplasia
* TOTALS
2
2 1.5
Mesentery
Fat, Necrosis
+
2
+
2
Pancreas
Atrophy
Basophilic Focus
Inflammation, Acute
+
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
2
+
+
+
+
7
7 2.0
+
1
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
2
50
+
50
4 1.5
4 2.0
1 2.0
2
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Tooth
Inflammation, Chronic Active
1 2.0
1
1 4.0
CARDIOVASCULAR SYSTEM
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
+
1
+
1
+
1
+
2
+
1
+
1
+
+
1
+
1
+
2
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
+
1
+
1
+
+
2
+
+
1
50
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
50
40 1.2
ENDOCRINE SYSTEM
Adrenal Cortex
Degeneration, Cystic
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 24
1 1.0
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
4
3
9
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
0
4
0
7
3
0
0
7
0
4
0
7
3
0
0
7
3
0
0
6
3
7
0
7
2
9
0
6
5
3
0
7
3
0
0
7
3
0
0
7
2
9
0
7
3
1
0
7
3
0
0
7
3
0
0
5
0
5
0
7
3
0
0
7
2
9
0
6
2
0
0
0
2
2
6
0
0
2
2
7
0
0
2
2
8
0
0
2
2
9
0
0
2
3
0
0
0
2
3
1
0
0
2
3
2
0
0
2
3
3
0
0
2
3
4
0
0
2
3
5
0
0
2
3
6
0
0
2
3
7
0
0
2
3
8
0
0
2
3
9
0
0
2
4
0
0
0
2
4
1
0
0
2
4
2
0
0
2
4
3
0
0
2
4
4
0
0
2
4
5
0
0
2
4
6
0
0
2
4
7
0
0
2
4
8
0
0
2
4
9
0
0
2
5
0
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
+
+
+
M
+
+
+
+
+
+
+
+
+
+
Hyperplasia
Hypertrophy
2
2
Adrenal Medulla
Hyperplasia
+
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Parathyroid Gland
+
+
+
M
+
+
+
+
+
+
+
M
+
M
+
+
+
+
+
+
+
M
+
+
+
43
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
+
+
2
+
+
2
+
1
+
2
+
2
+
2
+
2
+
2
+
+
+
+
3
+
+
2
+
+
2
+
2
+
2
+
+
+
+
50
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
1
+
+
+
+
+
1
+
2
+
+
1
+
+
1
+
2
+
+
1
+
2
+
1
+
4
+
1
+
1
+
Epididymis
+
Preputial Gland
Inflammation, Chronic Active
+
Prostate
Hyperplasia
+
+
+
+
+
+
+
2
* TOTALS
2
2
+
+
+
+
25 2.0
21 2.0
48
1 2.0
21 2.0
1 2.0
2
+
1
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
50
+
1
+
30 1.4
1 2.0
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
+
+
+
+
+
3
+
+
+
3
+
+
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 25
+
+
+
5 2.6
+
2
+
2
+
+
+
1
+
+
1
+
2
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
17 1.9
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
4
3
9
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
0
4
0
7
3
0
0
7
0
4
0
7
3
0
0
7
3
0
0
6
3
7
0
7
2
9
0
6
5
3
0
7
3
0
0
7
3
0
0
7
2
9
0
7
3
1
0
7
3
0
0
7
3
0
0
5
0
5
0
7
3
0
0
7
2
9
0
6
2
0
0
0
2
2
6
0
0
2
2
7
0
0
2
2
8
0
0
2
2
9
0
0
2
3
0
0
0
2
3
1
0
0
2
3
2
0
0
2
3
3
0
0
2
3
4
0
0
2
3
5
0
0
2
3
6
0
0
2
3
7
0
0
2
3
8
0
0
2
3
9
0
0
2
4
0
0
0
2
4
1
0
0
2
4
2
0
0
2
4
3
0
0
2
4
4
0
0
2
4
5
0
0
2
4
6
0
0
2
4
7
0
0
2
4
8
0
0
2
4
9
0
0
2
5
0
Inflammation, Chronic Active
* TOTALS
2
2 2.5
Seminal Vesicle
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Testes
Atrophy
Edema
Artery, Inflammation, Chronic Active
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
2
+
1
2
+
2
+
3
2
+
+
+
+
+
+
2
2
2
8 2.1
11 2.1
2 2.0
2
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
Lymph Node
Lumbar, Ectasia
Lumbar, Infiltration Cellular, Plasma Cell
Renal, Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
50
5
2 2.5
1 2.0
2 2.0
1
Lymph Node, Bronchial
+
+
M
M
+
+
+
M
+
+
M
M
+
+
+
M
M
+
+
M
M
+
+
+
+
40
Lymph Node, Mandibular
Ectasia
Hyperplasia, Lymphoid
Infiltration Cellular, Plasma Cell
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
M
+
+
+
+
+
+
46
Lymph Node, Mediastinal
+
M
M
+
+
+
+
+
+
+
+
+
+
+
+
M
+
M
+
+
+
M
+
+
+
45
Lymph Node, Mesenteric
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Spleen
Inflammation, Granulomatous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
50
2 2.5
1 3.0
1 2.0
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 26
1 3.0
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
4
3
9
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
0
4
0
7
3
0
0
7
0
4
0
7
3
0
0
7
3
0
0
6
3
7
0
7
2
9
0
6
5
3
0
7
3
0
0
7
3
0
0
7
2
9
0
7
3
1
0
7
3
0
0
7
3
0
0
5
0
5
0
7
3
0
0
7
2
9
0
6
2
0
0
0
2
2
6
0
0
2
2
7
0
0
2
2
8
0
0
2
2
9
0
0
2
3
0
0
0
2
3
1
0
0
2
3
2
0
0
2
3
3
0
0
2
3
4
0
0
2
3
5
0
0
2
3
6
0
0
2
3
7
0
0
2
3
8
0
0
2
3
9
0
0
2
4
0
0
0
2
4
1
0
0
2
4
2
0
0
2
4
3
0
0
2
4
4
0
0
2
4
5
0
0
2
4
6
0
0
2
4
7
0
0
2
4
8
0
0
2
4
9
0
0
2
5
0
* TOTALS
M
+
M
I
+
+
I
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
43
Mammary Gland
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
+
M
M
M
+
6
Skin
Cyst Epithelial Inclusion
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
4
4
4
4
4
4
4
4
+
X
2
+
+
+
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
Thymus
INTEGUMENTARY SYSTEM
3
4
4
1
23 3.7
MUSCULOSKELETAL SYSTEM
Bone
+
+
+
+
Skeletal Muscle
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
3
50
2
1 3.0
NERVOUS SYSTEM
Brain
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Peripheral Nerve
+
+
4
Spinal Cord
+
+
4
RESPIRATORY SYSTEM
Larynx
Inflammation, Acute
Inflammation, Chronic Active
Metaplasia, Squamous
+
1
+
3
+
2
+
1
+
2
+
1
+
1
+
2
+
1
+
1
+
1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 27
+
3
+
2
+
1
+
2
+
2
+
1
+
+
1
1
1
+
2
+
2
+
1
+
2
1
+
1
+
50
2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
1 1.0
2 1.0
47 1.5
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
4
3
9
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
0
4
0
7
3
0
0
7
0
4
0
7
3
0
0
7
3
0
0
6
3
7
0
7
2
9
0
6
5
3
0
7
3
0
0
7
3
0
0
7
2
9
0
7
3
1
0
7
3
0
0
7
3
0
0
5
0
5
0
7
3
0
0
7
2
9
0
6
2
0
0
0
2
2
6
0
0
2
2
7
0
0
2
2
8
0
0
2
2
9
0
0
2
3
0
0
0
2
3
1
0
0
2
3
2
0
0
2
3
3
0
0
2
3
4
0
0
2
3
5
0
0
2
3
6
0
0
2
3
7
0
0
2
3
8
0
0
2
3
9
0
0
2
4
0
0
0
2
4
1
0
0
2
4
2
0
0
2
4
3
0
0
2
4
4
0
0
2
4
5
0
0
2
4
6
0
0
2
4
7
0
0
2
4
8
0
0
2
4
9
0
0
2
5
0
Lung
Inflammation, Lymphohistiocytic
Inflammation, Acute
Metaplasia, Squamous
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
+
+
+
1
+
+
+
+
+
1
+
1
+
+
1
+
+
+
+
+
+
1
+
+
1
+
+
1
+
+
1
+
+
1
50
Nose
Inflammation, Acute
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
50
Trachea
Inflammation, Acute
+
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
2
* TOTALS
14
2
1
6
1
1.0
1.5
1.0
1.8
1.0
2
1
4
1
1
39
20
50
2.0
3.0
1.5
1.1
2.8
1
17 1.1
1
1
2
2
2
+
+
3
1
2
2
+
1
3
+
1
3
+
1
2
+
2
1
3
1
+
+
+
+
+
+
1
3
2
1
2
1
1
+
+
+
3
3
+
+
+
+
2
1
4
1
2
3
3
1
2
1
+
+
+
3
+
1
2
+
1
2
1
3
2
+
1
1
3
+
1
1
3
1
+
+
+
+
+
+
+
+
+
+
1
1
3
1
1
4
1
1
4
1
1
1
1
1
+
+
+
+
3
+
2
1
1
3
2
2
+
1
+
+
+
2
+
+
49
1 1.0
SPECIAL SENSES SYSTEM
Eye
Cataract
Cornea, Inflammation, Chronic Active
Retina, Atrophy
+
Harderian Gland
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
3 3.0
1 3.0
3 2.7
3
2
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 28
+
1
+
+
+
+
+
+
1
+
+
+
+
+
+
+
50
7 1.3
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
4
3
9
0
7
3
0
0
7
3
0
0
7
3
1
0
7
3
0
0
7
3
0
0
7
0
4
0
7
3
0
0
7
0
4
0
7
3
0
0
7
3
0
0
6
3
7
0
7
2
9
0
6
5
3
0
7
3
0
0
7
3
0
0
7
2
9
0
7
3
1
0
7
3
0
0
7
3
0
0
5
0
5
0
7
3
0
0
7
2
9
0
6
2
0
0
0
2
2
6
0
0
2
2
7
0
0
2
2
8
0
0
2
2
9
0
0
2
3
0
0
0
2
3
1
0
0
2
3
2
0
0
2
3
3
0
0
2
3
4
0
0
2
3
5
0
0
2
3
6
0
0
2
3
7
0
0
2
3
8
0
0
2
3
9
0
0
2
4
0
0
0
2
4
1
0
0
2
4
2
0
0
2
4
3
0
0
2
4
4
0
0
2
4
5
0
0
2
4
6
0
0
2
4
7
0
0
2
4
8
0
0
2
4
9
0
0
2
5
0
Hypertrophy
2
1
* TOTALS
1
Zymbal's Gland
+
3 1.3
+
2
URINARY SYSTEM
Kidney
Cyst
Hydronephrosis
Inflammation, Suppurative
Nephropathy
Transitional Epithelium, Hyperplasia
+
Urinary Bladder
Calculus Gross Observation
Inflammation, Chronic Active
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1
1
3
38
1
1
1
+
2
3
2
3
1
1
2
2
+
+
+
+
+
+
+
+
+
2
2
2
1
1
+
+
+
+
+
+
2
1
1
2
+
+
+
+
+
2
2
1
+
+
+
2.0
2.0
1.7
1.8
3.0
50
1 2.0
1 1.0
1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 29
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
1
0
7
2
9
0
7
2
9
0
7
3
1
0
7
1
1
0
5
6
4
0
7
0
4
0
6
5
3
0
7
0
4
0
7
0
4
0
7
2
9
0
7
2
6
0
7
2
9
0
7
3
0
0
5
6
4
0
7
3
0
0
7
3
0
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
2
0
6
2
0
0
7
2
9
0
7
3
1
0
7
2
9
0
0
4
0
1
0
0
4
0
2
0
0
4
0
3
0
0
4
0
4
0
0
4
0
5
0
0
4
0
6
0
0
4
0
7
0
0
4
0
8
0
0
4
0
9
0
0
4
1
0
0
0
4
1
1
0
0
4
1
2
0
0
4
1
3
0
0
4
1
4
0
0
4
1
5
0
0
4
1
6
0
0
4
1
7
0
0
4
1
8
0
0
4
1
9
0
0
4
2
0
0
0
4
2
1
0
0
4
2
2
0
0
4
2
3
0
0
4
2
4
0
0
4
2
5
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Necrosis
Bile Duct, Dilatation
+
1
X
X
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
X
X
X
+
1
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
males
(cont...)
ALIMENTARY SYSTEM
X
X
X
X
X
X
X
X
X
X
X
X
2
Mesentery
Fat, Necrosis
+
2
Oral Mucosa
Developmental Malformation
Pancreas
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 30
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
1
0
7
2
9
0
7
2
9
0
7
3
1
0
7
1
1
0
5
6
4
0
7
0
4
0
6
5
3
0
7
0
4
0
7
0
4
0
7
2
9
0
7
2
6
0
7
2
9
0
7
3
0
0
5
6
4
0
7
3
0
0
7
3
0
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
2
0
6
2
0
0
7
2
9
0
7
3
1
0
7
2
9
0
0
4
0
1
0
0
4
0
2
0
0
4
0
3
0
0
4
0
4
0
0
4
0
5
0
0
4
0
6
0
0
4
0
7
0
0
4
0
8
0
0
4
0
9
0
0
4
1
0
0
0
4
1
1
0
0
4
1
2
0
0
4
1
3
0
0
4
1
4
0
0
4
1
5
0
0
4
1
6
0
0
4
1
7
0
0
4
1
8
0
0
4
1
9
0
0
4
2
0
0
0
4
2
1
0
0
4
2
2
0
0
4
2
3
0
0
4
2
4
0
0
4
2
5
Atrophy
Basophilic Focus
males
(cont...)
1
X
X
Salivary Glands
Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
Necrosis
+
+
+
1
+
1
+
2
+
1
+
2
+
+
+
+
+
+
+
1
+
+
1
+
1
+
1
+
1
+
1
+
2
+
1
+
1
+
1
+
1
Adrenal Cortex
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
2
2
2
2
2
2
2
2
2
2
2
2
2
1
+
2
3
+
2
2
+
1
2
Adrenal Medulla
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
2
+
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
CARDIOVASCULAR SYSTEM
ENDOCRINE SYSTEM
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 31
2
2
2
2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
1
0
7
2
9
0
7
2
9
0
7
3
1
0
7
1
1
0
5
6
4
0
7
0
4
0
6
5
3
0
7
0
4
0
7
0
4
0
7
2
9
0
7
2
6
0
7
2
9
0
7
3
0
0
5
6
4
0
7
3
0
0
7
3
0
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
2
0
6
2
0
0
7
2
9
0
7
3
1
0
7
2
9
0
0
4
0
1
0
0
4
0
2
0
0
4
0
3
0
0
4
0
4
0
0
4
0
5
0
0
4
0
6
0
0
4
0
7
0
0
4
0
8
0
0
4
0
9
0
0
4
1
0
0
0
4
1
1
0
0
4
1
2
0
0
4
1
3
0
0
4
1
4
0
0
4
1
5
0
0
4
1
6
0
0
4
1
7
0
0
4
1
8
0
0
4
1
9
0
0
4
2
0
0
0
4
2
1
0
0
4
2
2
0
0
4
2
3
0
0
4
2
4
0
0
4
2
5
Parathyroid Gland
Hyperplasia
M
+
+
M
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
M
+
+
+
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
2
+
2
+
+
+
+
+
+
+
+
+
+
3
+
+
2
+
+
+
2
+
+
+
+
+
+
+
+
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
1
+
+
1
+
2
+
+
+
+
1
+
+
1
+
+
2
+
1
1
+
+
+
1
+
+
1
+
1
2
+
+
+
1
+
1
+
+
2
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
3
males
(cont...)
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Preputial Gland
Inflammation, Chronic Active
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Prostate
Hyperplasia
Inflammation, Chronic Active
+
+
3
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
1
+
+
1
+
1
+
+
+
2
+
+
Seminal Vesicle
Inflammation, Chronic Active
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Testes
Atrophy
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
2
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 32
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
1
0
7
2
9
0
7
2
9
0
7
3
1
0
7
1
1
0
5
6
4
0
7
0
4
0
6
5
3
0
7
0
4
0
7
0
4
0
7
2
9
0
7
2
6
0
7
2
9
0
7
3
0
0
5
6
4
0
7
3
0
0
7
3
0
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
2
0
6
2
0
0
7
2
9
0
7
3
1
0
7
2
9
0
0
4
0
1
0
0
4
0
2
0
0
4
0
3
0
0
4
0
4
0
0
4
0
5
0
0
4
0
6
0
0
4
0
7
0
0
4
0
8
0
0
4
0
9
0
0
4
1
0
0
0
4
1
1
0
0
4
1
2
0
0
4
1
3
0
0
4
1
4
0
0
4
1
5
0
0
4
1
6
0
0
4
1
7
0
0
4
1
8
0
0
4
1
9
0
0
4
2
0
0
0
4
2
1
0
0
4
2
2
0
0
4
2
3
0
0
4
2
4
0
0
4
2
5
2
2
2
2
+
+
+
+
Edema
3
2
2
2
3
males
(cont...)
3
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
Lymph Node
Iliac, Ectasia
Iliac, Inflammation, Chronic Active
Lumbar, Ectasia
Lumbar, Infiltration Cellular, Plasma Cell
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
3
3
Lymph Node, Bronchial
Hyperplasia, Lymphohistiocytic
I
+
+
+
1
+
+
1
M
+
+
+
+
+
+
+
M
M
+
1
M
M
+
M
+
+
+
+
1
Lymph Node, Mandibular
Infiltration Cellular, Plasma Cell
M
M
M
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
M
+
+
+
+
+
+
Lymph Node, Mediastinal
Hyperplasia, Lymphohistiocytic
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
Lymph Node, Mesenteric
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Spleen
Angiectasis
Hematopoietic Cell Proliferation
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
Thymus
Cyst
+
+
+
+
3
+
3
+
+
+
+
+
2
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 33
+
+
+
M
3
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
1
0
7
2
9
0
7
2
9
0
7
3
1
0
7
1
1
0
5
6
4
0
7
0
4
0
6
5
3
0
7
0
4
0
7
0
4
0
7
2
9
0
7
2
6
0
7
2
9
0
7
3
0
0
5
6
4
0
7
3
0
0
7
3
0
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
2
0
6
2
0
0
7
2
9
0
7
3
1
0
7
2
9
0
0
4
0
1
0
0
4
0
2
0
0
4
0
3
0
0
4
0
4
0
0
4
0
5
0
0
4
0
6
0
0
4
0
7
0
0
4
0
8
0
0
4
0
9
0
0
4
1
0
0
0
4
1
1
0
0
4
1
2
0
0
4
1
3
0
0
4
1
4
0
0
4
1
5
0
0
4
1
6
0
0
4
1
7
0
0
4
1
8
0
0
4
1
9
0
0
4
2
0
0
0
4
2
1
0
0
4
2
2
0
0
4
2
3
0
0
4
2
4
0
0
4
2
5
Mammary Gland
M
M
M
M
M
M
M
M
+
M
M
M
+
M
M
M
M
M
M
M
M
M
M
M
M
Skin
Inflammation, Chronic Active
+
4
+
4
+
+
4
+
4
+
+
4
+
2
+
4
+
4
+
+
4
+
4
+
4
+
4
+
+
+
+
+
4
+
4
+
4
+
4
+
4
+
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Peripheral Nerve
+
M
+
+
+
+
+
Spinal Cord
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
males
(cont...)
INTEGUMENTARY SYSTEM
MUSCULOSKELETAL SYSTEM
Bone
Inflammation, Chronic Active
Skeletal Muscle
+
NERVOUS SYSTEM
Brain
Hemorrhage
+
+
+
+
+
RESPIRATORY SYSTEM
Larynx
Foreign Body
Inflammation, Chronic Active
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
2
1
3
3
3
2
2
1
3
2
3
2
3
3
3
2
2
2
1
2
3
2
2
1
Lung
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 34
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
1
0
7
2
9
0
7
2
9
0
7
3
1
0
7
1
1
0
5
6
4
0
7
0
4
0
6
5
3
0
7
0
4
0
7
0
4
0
7
2
9
0
7
2
6
0
7
2
9
0
7
3
0
0
5
6
4
0
7
3
0
0
7
3
0
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
2
0
6
2
0
0
7
2
9
0
7
3
1
0
7
2
9
0
0
4
0
1
0
0
4
0
2
0
0
4
0
3
0
0
4
0
4
0
0
4
0
5
0
0
4
0
6
0
0
4
0
7
0
0
4
0
8
0
0
4
0
9
0
0
4
1
0
0
0
4
1
1
0
0
4
1
2
0
0
4
1
3
0
0
4
1
4
0
0
4
1
5
0
0
4
1
6
0
0
4
1
7
0
0
4
1
8
0
0
4
1
9
0
0
4
2
0
0
0
4
2
1
0
0
4
2
2
0
0
4
2
3
0
0
4
2
4
0
0
4
2
5
1
2
1
2
1
3
1
1
2
1
1
1
1
1
1
1
1
2
2
1
1
1
2
2
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
1
2
1
Nose
Foreign Body
Inflammation, Acute
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
1
4
2
2
2
2
2
1
3
2
1
3
2
1
2
3
1
4
2
1
3
1
2
3
1
3
Trachea
+
Eye
Cataract
Retina, Atrophy
Harderian Gland
Hyperplasia
3
3
3
3
1
+
+
+
+
+
+
+
+
+
+
2
1
2
1
3
1
1
3
3
3
3
1
3
1
3
1
1
3
1
3
2
1
3
1
1
1
1
3
1
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
2
+
+
2
+
+
+
+
+
+
+
2
+
+
1
+
+
1
1
3
1
3
1
3
+
1
males
(cont...)
1
1
3
SPECIAL SENSES SYSTEM
Ear
Zymbal's Gland
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 35
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
1
0
7
2
9
0
7
2
9
0
7
3
1
0
7
1
1
0
5
6
4
0
7
0
4
0
6
5
3
0
7
0
4
0
7
0
4
0
7
2
9
0
7
2
6
0
7
2
9
0
7
3
0
0
5
6
4
0
7
3
0
0
7
3
0
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
2
0
6
2
0
0
7
2
9
0
7
3
1
0
7
2
9
0
0
4
0
1
0
0
4
0
2
0
0
4
0
3
0
0
4
0
4
0
0
4
0
5
0
0
4
0
6
0
0
4
0
7
0
0
4
0
8
0
0
4
0
9
0
0
4
1
0
0
0
4
1
1
0
0
4
1
2
0
0
4
1
3
0
0
4
1
4
0
0
4
1
5
0
0
4
1
6
0
0
4
1
7
0
0
4
1
8
0
0
4
1
9
0
0
4
2
0
0
0
4
2
1
0
0
4
2
2
0
0
4
2
3
0
0
4
2
4
0
0
4
2
5
Kidney
Cyst
Hydronephrosis
Inflammation, Suppurative
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
2
+
+
+
2
1
Urinary Bladder
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
males
(cont...)
URINARY SYSTEM
1
1
+
+
2
3
+
+
+
1
3
1
3
1
2
2
3
1
1
2
3
2
2
1
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 36
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
0
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
6
3
9
0
7
3
1
0
3
0
9
0
7
2
9
0
7
2
9
0
7
2
9
0
6
4
6
0
6
8
4
0
7
2
2
0
0
4
2
6
0
0
4
2
7
0
0
4
2
8
0
0
4
2
9
0
0
4
3
0
0
0
4
3
1
0
0
4
3
2
0
0
4
3
3
0
0
4
3
4
0
0
4
3
5
0
0
4
3
6
0
0
4
3
7
0
0
4
3
8
0
0
4
3
9
0
0
4
4
0
0
0
4
4
1
0
0
4
4
2
0
0
4
4
3
0
0
4
4
4
0
0
4
4
5
0
0
4
4
6
0
0
4
4
7
0
0
4
4
8
0
0
4
4
9
0
0
4
5
0
* TOTALS
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
A
+
+
+
+
A
+
47
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
A
+
+
+
+
A
+
47
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
A
+
+
+
+
A
+
47
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
A
+
+
+
+
A
+
47
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
A
+
+
+
+
A
+
47
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
A
+
+
+
+
A
+
47
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Necrosis
Bile Duct, Dilatation
+
1
X
+
1
+
1
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
X
X
+
1
X
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
ALIMENTARY SYSTEM
X
X
X
X
X
X
X
X
8 1.0
18
17
1
1 2.0
2 2.5
X
X
2
3
Mesentery
Fat, Necrosis
1
1 2.0
Oral Mucosa
Developmental Malformation
Pancreas
+
X
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 37
+
+
+
+
+
+
+
A
+
+
+
+
1
1
+
+
49
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
0
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
6
3
9
0
7
3
1
0
3
0
9
0
7
2
9
0
7
2
9
0
7
2
9
0
6
4
6
0
6
8
4
0
7
2
2
0
0
4
2
6
0
0
4
2
7
0
0
4
2
8
0
0
4
2
9
0
0
4
3
0
0
0
4
3
1
0
0
4
3
2
0
0
4
3
3
0
0
4
3
4
0
0
4
3
5
0
0
4
3
6
0
0
4
3
7
0
0
4
3
8
0
0
4
3
9
0
0
4
4
0
0
0
4
4
1
0
0
4
4
2
0
0
4
4
3
0
0
4
4
4
0
0
4
4
5
0
0
4
4
6
0
0
4
4
7
0
0
4
4
8
0
0
4
4
9
0
0
4
5
0
Atrophy
Basophilic Focus
2
+
+
2
+
+
+
+
* TOTALS
1
Salivary Glands
Atrophy
+
+
+
+
+
+
+
Stomach, Forestomach
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4 1.5
2
+
1
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
A
+
+
+
+
+
1
+
49
1 1.0
1 1.0
CARDIOVASCULAR SYSTEM
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
Necrosis
+
2
+
1
+
1
+
+
1
+
2
+
1
+
1
+
+
+
1
+
2
+
1
+
+
1
+
2
+
1
+
+
+
+
+
+
1
+
2
+
1
50
+
+
+
49
2
2
+
+
32 1.3
1 1.0
1
ENDOCRINE SYSTEM
Adrenal Cortex
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
Adrenal Medulla
Hyperplasia
+
Islets, Pancreatic
+
+
+
+
2
2
+
2
+
+
+
+
+
+
+
2
2
2
+
+
+
+
+
+
+
+
+
+
+
+
+
2
2
2
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 38
A
A
+
+
+
2
2
+
+
+
+
+
+
2
2
2
1
2
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
2
2
+
2
+
+
+
+
+
3 1.3
28 2.0
14 1.9
49
4 2.3
+
+
+
+
49
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
0
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
6
3
9
0
7
3
1
0
3
0
9
0
7
2
9
0
7
2
9
0
7
2
9
0
6
4
6
0
6
8
4
0
7
2
2
0
0
4
2
6
0
0
4
2
7
0
0
4
2
8
0
0
4
2
9
0
0
4
3
0
0
0
4
3
1
0
0
4
3
2
0
0
4
3
3
0
0
4
3
4
0
0
4
3
5
0
0
4
3
6
0
0
4
3
7
0
0
4
3
8
0
0
4
3
9
0
0
4
4
0
0
0
4
4
1
0
0
4
4
2
0
0
4
4
3
0
0
4
4
4
0
0
4
4
5
0
0
4
4
6
0
0
4
4
7
0
0
4
4
8
0
0
4
4
9
0
0
4
5
0
* TOTALS
Parathyroid Gland
Hyperplasia
+
+
M
+
+
+
M
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
44
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
2
+
1
+
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
2
+
1
+
3
+
A
Epididymis
+
+
+
Preputial Gland
Inflammation, Chronic Active
+
+
+
Prostate
Hyperplasia
Inflammation, Chronic Active
+
Seminal Vesicle
Inflammation, Chronic Active
+
Testes
Atrophy
+
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
+
+
2
+
+
2
+
+
+
+
+
1 2.0
+
+
+
+
3
+
+
+
+
2
+
2
+
+
+
+
1
+
1
2
+
1
+
2
+
+
2
50
+
49
13 2.1
1 2.0
2
+
1
+
1
+
1
1
+
2
+
2
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
3
+
1
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
3
+
+
+
+
+
+
+
3
+
+
+
50
+
3
+
+
3
+
+
2
+
+
+
+
+
30 1.4
5 1.8
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
+
+
+
+
2
+
+
+
+
+
2
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
1
+
+
A
+
1
+
+
+
3 2.7
+
+
50
12 1.8
4 2.5
3
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 39
A
+
+
+
+
+
+
48
2 2.5
+
1
+
+
+
+
+
+
+
+
4
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
5 2.8
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
0
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
6
3
9
0
7
3
1
0
3
0
9
0
7
2
9
0
7
2
9
0
7
2
9
0
6
4
6
0
6
8
4
0
7
2
2
0
0
4
2
6
0
0
4
2
7
0
0
4
2
8
0
0
4
2
9
0
0
4
3
0
0
0
4
3
1
0
0
4
3
2
0
0
4
3
3
0
0
4
3
4
0
0
4
3
5
0
0
4
3
6
0
0
4
3
7
0
0
4
3
8
0
0
4
3
9
0
0
4
4
0
0
0
4
4
1
0
0
4
4
2
0
0
4
4
3
0
0
4
4
4
0
0
4
4
5
0
0
4
4
6
0
0
4
4
7
0
0
4
4
8
0
0
4
4
9
0
0
4
5
0
3
3
1
3
+
+
+
+
Edema
2
2
2
* TOTALS
2
18 2.3
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
Lymph Node
Iliac, Ectasia
Iliac, Inflammation, Chronic Active
Lumbar, Ectasia
Lumbar, Infiltration Cellular, Plasma Cell
+
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
+
7
1
1
2
2
1
3
Lymph Node, Bronchial
Hyperplasia, Lymphohistiocytic
+
+
Lymph Node, Mandibular
Infiltration Cellular, Plasma Cell
+
Lymph Node, Mediastinal
Hyperplasia, Lymphohistiocytic
+
Lymph Node, Mesenteric
+
+
+
Spleen
Angiectasis
Hematopoietic Cell Proliferation
Necrosis
+
+
+
Thymus
Cyst
M
+
+
+
1
+
+
+
+
+
+
1
+
+
+
+
+
+
M
+
+
+
M
+
M
+
+
+
+
+
+
2
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
1
+
+
+
+
M
+
4
+
+
+
M
+
+
+
+
1
+
+
+
+
1
+
+
+
M
37
10 1.1
+
44
1 4.0
+
1
+
+
+
+
+
+
+
+
50
+
+
+
+
+
M
+
+
+
+
+
+
49
+
+
+
+
+
+
+
+
+
+
+
+
50
4 1.5
1 3.0
4 2.8
1 2.0
3
2
+
+
+
+
+
+
+
M
+
+
+
+
M
+
2.0
4.0
2.0
3.0
+
+
I
+
+
M
+
+
+
+
44
1 3.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 40
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
0
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
6
3
9
0
7
3
1
0
3
0
9
0
7
2
9
0
7
2
9
0
7
2
9
0
6
4
6
0
6
8
4
0
7
2
2
0
0
4
2
6
0
0
4
2
7
0
0
4
2
8
0
0
4
2
9
0
0
4
3
0
0
0
4
3
1
0
0
4
3
2
0
0
4
3
3
0
0
4
3
4
0
0
4
3
5
0
0
4
3
6
0
0
4
3
7
0
0
4
3
8
0
0
4
3
9
0
0
4
4
0
0
0
4
4
1
0
0
4
4
2
0
0
4
4
3
0
0
4
4
4
0
0
4
4
5
0
0
4
4
6
0
0
4
4
7
0
0
4
4
8
0
0
4
4
9
0
0
4
5
0
* TOTALS
Mammary Gland
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
M
+
M
M
3
Skin
Inflammation, Chronic Active
+
4
+
3
+
4
+
+
+
4
+
+
4
+
+
4
+
3
+
+
+
+
+
+
+
4
+
+
+
3
+
4
+
+
3
+
4
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
INTEGUMENTARY SYSTEM
30 3.8
MUSCULOSKELETAL SYSTEM
Bone
Inflammation, Chronic Active
+
+
+
+
+
+
4
+
1 4.0
Skeletal Muscle
1
NERVOUS SYSTEM
Brain
Hemorrhage
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
50
1 1.0
Peripheral Nerve
6
Spinal Cord
7
RESPIRATORY SYSTEM
Larynx
Foreign Body
Inflammation, Chronic Active
Metaplasia, Squamous
+
+
+
2
2
2
Lung
+
+
+
+
+
+
+
+
+
+
+
2
3
1
2
3
2
2
3
2
3
2
2
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 41
+
+
+
+
+
1
+
X
2
3
+
+
+
+
+
+
+
+
2
3
3
2
1
2
3
3
2
+
+
+
+
+
+
+
+
+
+
+
50
1
2 1.5
50 2.2
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
0
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
6
3
9
0
7
3
1
0
3
0
9
0
7
2
9
0
7
2
9
0
7
2
9
0
6
4
6
0
6
8
4
0
7
2
2
0
0
4
2
6
0
0
4
2
7
0
0
4
2
8
0
0
4
2
9
0
0
4
3
0
0
0
4
3
1
0
0
4
3
2
0
0
4
3
3
0
0
4
3
4
0
0
4
3
5
0
0
4
3
6
0
0
4
3
7
0
0
4
3
8
0
0
4
3
9
0
0
4
4
0
0
0
4
4
1
0
0
4
4
2
0
0
4
4
3
0
0
4
4
4
0
0
4
4
5
0
0
4
4
6
0
0
4
4
7
0
0
4
4
8
0
0
4
4
9
0
0
4
5
0
1
1
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
+
+
+
+
Trachea
+
+
+
+
+
1
+
41 1.1
11 1.9
5 1.0
2
1
Nose
Foreign Body
Inflammation, Acute
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
* TOTALS
+
+
+
+
+
+
+
+
+
+
+
X
+
1
+
+
+
+
50
3
1
3
2
4
1
1
1
47
25
50
2
1
25 1.1
+
+
2
3
2
4
3
3
1
4
2
2
3
2
1
+
+
+
+
1
1
3
1
2
2
2
2
1
+
+
3
1
2
2
2
1
+
+
2
1
3
2
2
3
2
1
3
1
+
+
1
1
2
3
3
1
+
+
+
1
1
4
4
1
1
3
1
+
+
1
1
3
2
1
+
+
+
3
1
3
3
2
4
2
1
3
1
2
1
+
+
+
3
3
+
2.0
4.0
2.0
1.1
3.0
50
SPECIAL SENSES SYSTEM
Ear
+
Eye
Cataract
Retina, Atrophy
+
Harderian Gland
Hyperplasia
+
2
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
+
+
A
2
+
+
1
+
+
1
+
+
+
+
+
+
1
+
+
48
1 4.0
2 2.0
2
+
+
+
2
+
2
Zymbal's Gland
+
+
+
+
2
+
+
+
+
+
1
+
+
+
Page 42
+
50
12 1.6
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
+
1
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
0
0
0
7
2
9
0
7
3
0
0
7
2
9
0
7
3
0
0
6
3
9
0
7
3
1
0
3
0
9
0
7
2
9
0
7
2
9
0
7
2
9
0
6
4
6
0
6
8
4
0
7
2
2
0
0
4
2
6
0
0
4
2
7
0
0
4
2
8
0
0
4
2
9
0
0
4
3
0
0
0
4
3
1
0
0
4
3
2
0
0
4
3
3
0
0
4
3
4
0
0
4
3
5
0
0
4
3
6
0
0
4
3
7
0
0
4
3
8
0
0
4
3
9
0
0
4
4
0
0
0
4
4
1
0
0
4
4
2
0
0
4
4
3
0
0
4
4
4
0
0
4
4
5
0
0
4
4
6
0
0
4
4
7
0
0
4
4
8
0
0
4
4
9
0
0
4
5
0
* TOTALS
Kidney
Cyst
Hydronephrosis
Inflammation, Suppurative
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
A
+
+
+
+
+
+
49
Urinary Bladder
+
DAY ON TEST
WISTAR HAN RATS MALE
30 mg/m3
ANIMAL ID
URINARY SYSTEM
3
2
2
38
1
4
2
1
1
1
3
3
1
2
1
3
2
3
1
+
A
+
+
+
+
3
2
1
+
+
1
4
2
+
+
+
2
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 43
+
+
A
+
48
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
2.0
2.5
1.5
1.9
2.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
0
4
0
7
0
4
0
5
9
5
0
5
0
4
0
7
3
1
0
7
3
1
0
7
3
0
0
7
3
1
0
7
3
0
0
7
2
9
0
7
2
5
0
2
0
2
0
6
4
6
0
4
7
8
0
7
3
0
0
7
3
1
0
6
7
5
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
2
0
6
9
5
0
7
0
4
0
7
3
0
0
7
3
1
0
0
6
0
1
0
0
6
0
2
0
0
6
0
3
0
0
6
0
4
0
0
6
0
5
0
0
6
0
6
0
0
6
0
7
0
0
6
0
8
0
0
6
0
9
0
0
6
1
0
0
0
6
1
1
0
0
6
1
2
0
0
6
1
3
0
0
6
1
4
0
0
6
1
5
0
0
6
1
6
0
0
6
1
7
0
0
6
1
8
0
0
6
1
9
0
0
6
2
0
0
0
6
2
1
0
0
6
2
2
0
0
6
2
3
0
0
6
2
4
0
0
6
2
5
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Colon
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Rectum
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
I
+
+
+
+
+
+
+
Intestine Small, Duodenum
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Ileum
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Jejunum
Inflammation, Chronic
Lymphatic, Angiectasis
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Fatty Change
Mixed Cell Focus
Necrosis
Bile Duct, Dilatation
+
+
+
+
+
2
+
1
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
X
X
X
X
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
males
(cont...)
ALIMENTARY SYSTEM
X
X
X
X
X
X
X
X
X
1
Mesentery
Pancreas
Atrophy
X
X
4
3
+
+
4
+
+
1
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 44
+
+
1
+
+
1
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
0
4
0
7
0
4
0
5
9
5
0
5
0
4
0
7
3
1
0
7
3
1
0
7
3
0
0
7
3
1
0
7
3
0
0
7
2
9
0
7
2
5
0
2
0
2
0
6
4
6
0
4
7
8
0
7
3
0
0
7
3
1
0
6
7
5
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
2
0
6
9
5
0
7
0
4
0
7
3
0
0
7
3
1
0
0
6
0
1
0
0
6
0
2
0
0
6
0
3
0
0
6
0
4
0
0
6
0
5
0
0
6
0
6
0
0
6
0
7
0
0
6
0
8
0
0
6
0
9
0
0
6
1
0
0
0
6
1
1
0
0
6
1
2
0
0
6
1
3
0
0
6
1
4
0
0
6
1
5
0
0
6
1
6
0
0
6
1
7
0
0
6
1
8
0
0
6
1
9
0
0
6
2
0
0
0
6
2
1
0
0
6
2
2
0
0
6
2
3
0
0
6
2
4
0
0
6
2
5
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Hyperplasia, Squamous
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
3
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
males
(cont...)
Basophilic Focus
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
Tooth
Dysplasia
+
2
CARDIOVASCULAR SYSTEM
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
+
1
+
1
+
1
+
2
+
1
+
1
+
1
+
1
+
2
+
2
+
1
+
+
1
+
+
+
1
+
+
1
+
1
+
1
+
+
2
+
2
+
1
+
1
Adrenal Cortex
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
2
2
2
2
2
2
2
2
2
2
2
Adrenal Medulla
Angiectasis
Hyperplasia
+
+
+
+
+
+
+
+
+
3
+
ENDOCRINE SYSTEM
2
2
2
2
+
+
+
+
+
+
2
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 45
2
3
+
+
+
2
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
0
4
0
7
0
4
0
5
9
5
0
5
0
4
0
7
3
1
0
7
3
1
0
7
3
0
0
7
3
1
0
7
3
0
0
7
2
9
0
7
2
5
0
2
0
2
0
6
4
6
0
4
7
8
0
7
3
0
0
7
3
1
0
6
7
5
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
2
0
6
9
5
0
7
0
4
0
7
3
0
0
7
3
1
0
0
6
0
1
0
0
6
0
2
0
0
6
0
3
0
0
6
0
4
0
0
6
0
5
0
0
6
0
6
0
0
6
0
7
0
0
6
0
8
0
0
6
0
9
0
0
6
1
0
0
0
6
1
1
0
0
6
1
2
0
0
6
1
3
0
0
6
1
4
0
0
6
1
5
0
0
6
1
6
0
0
6
1
7
0
0
6
1
8
0
0
6
1
9
0
0
6
2
0
0
0
6
2
1
0
0
6
2
2
0
0
6
2
3
0
0
6
2
4
0
0
6
2
5
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Parathyroid Gland
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
3
+
+
+
+
+
+
+
+
1
2
+
+
+
+
+
+
2
+
+
+
+
1
+
2
+
+
+
+
2
+
3
Thyroid Gland
C-cell, Hyperplasia
+
+
+
2
+
+
+
2
+
+
2
+
+
+
1
+
1
+
2
+
+
2
+
1
+
2
+
2
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
2
+
1
+
+
+
1
+
1
+
1
+
1
males
(cont...)
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland
Inflammation, Chronic Active
+
3
Epididymis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Preputial Gland
Inflammation, Chronic Active
Duct, Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
3
+
+
+
+
+
+
+
Prostate
Hyperplasia
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
2
+
+
+
+
+
+
3
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 46
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
0
4
0
7
0
4
0
5
9
5
0
5
0
4
0
7
3
1
0
7
3
1
0
7
3
0
0
7
3
1
0
7
3
0
0
7
2
9
0
7
2
5
0
2
0
2
0
6
4
6
0
4
7
8
0
7
3
0
0
7
3
1
0
6
7
5
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
2
0
6
9
5
0
7
0
4
0
7
3
0
0
7
3
1
0
0
6
0
1
0
0
6
0
2
0
0
6
0
3
0
0
6
0
4
0
0
6
0
5
0
0
6
0
6
0
0
6
0
7
0
0
6
0
8
0
0
6
0
9
0
0
6
1
0
0
0
6
1
1
0
0
6
1
2
0
0
6
1
3
0
0
6
1
4
0
0
6
1
5
0
0
6
1
6
0
0
6
1
7
0
0
6
1
8
0
0
6
1
9
0
0
6
2
0
0
0
6
2
1
0
0
6
2
2
0
0
6
2
3
0
0
6
2
4
0
0
6
2
5
Seminal Vesicle
Hyperplasia
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
Testes
Atrophy
Edema
Interstitial Cell, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
2
2
+
4
3
+
+
+
+
+
+
+
+
+
+
M
+
+
+
M
+
+
+
3
2
1
2
2
2
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
males
(cont...)
3
+
+
+
+
+
2
+
+
2
3
2
+
+
+
+
+
2
HEMATOPOIETIC SYSTEM
Bone Marrow
+
Lymph Node
Axillary, Ectasia
Iliac, Ectasia
Renal, Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
4
Lymph Node, Bronchial
Ectasia
Hyperplasia, Lymphohistiocytic
+
+
1
1
Lymph Node, Mandibular
Hyperplasia, Lymphoid
+
+
Lymph Node, Mediastinal
Hyperplasia, Lymphohistiocytic
+
3
Lymph Node, Mesenteric
Hemorrhage
+
M
+
+
+
+
+
M
M
+
+
M
M
M
M
M
2
2
2
2
2
+
+
M
+
+
+
M
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
2
+
2
+
+
+
3
+
+
+
3
+
+
2
+
+
1
+
+
+
+
1
+
+
3
+
2
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 47
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
0
4
0
7
0
4
0
5
9
5
0
5
0
4
0
7
3
1
0
7
3
1
0
7
3
0
0
7
3
1
0
7
3
0
0
7
2
9
0
7
2
5
0
2
0
2
0
6
4
6
0
4
7
8
0
7
3
0
0
7
3
1
0
6
7
5
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
2
0
6
9
5
0
7
0
4
0
7
3
0
0
7
3
1
0
0
6
0
1
0
0
6
0
2
0
0
6
0
3
0
0
6
0
4
0
0
6
0
5
0
0
6
0
6
0
0
6
0
7
0
0
6
0
8
0
0
6
0
9
0
0
6
1
0
0
0
6
1
1
0
0
6
1
2
0
0
6
1
3
0
0
6
1
4
0
0
6
1
5
0
0
6
1
6
0
0
6
1
7
0
0
6
1
8
0
0
6
1
9
0
0
6
2
0
0
0
6
2
1
0
0
6
2
2
0
0
6
2
3
0
0
6
2
4
0
0
6
2
5
Spleen
Angiectasis
Hematopoietic Cell Proliferation
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Thymus
+
+
+
M
+
+
+
+
I
+
+
+
+
+
I
+
+
M
+
+
+
+
+
+
+
Mammary Gland
+
M
M
M
M
M
M
M
M
M
M
M
M
M
+
M
M
M
M
M
+
M
M
M
M
Skin
Angiectasis
Cyst Epithelial Inclusion
Inflammation, Chronic Active
Thrombosis
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
3
3
4
4
2
4
4
4
4
3
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Brain
Compression
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Peripheral Nerve
+
+
+
+
Spinal Cord
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
males
(cont...)
3
INTEGUMENTARY SYSTEM
X
4
4
4
MUSCULOSKELETAL SYSTEM
Bone
NERVOUS SYSTEM
RESPIRATORY SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 48
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
0
4
0
7
0
4
0
5
9
5
0
5
0
4
0
7
3
1
0
7
3
1
0
7
3
0
0
7
3
1
0
7
3
0
0
7
2
9
0
7
2
5
0
2
0
2
0
6
4
6
0
4
7
8
0
7
3
0
0
7
3
1
0
6
7
5
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
2
0
6
9
5
0
7
0
4
0
7
3
0
0
7
3
1
0
0
6
0
1
0
0
6
0
2
0
0
6
0
3
0
0
6
0
4
0
0
6
0
5
0
0
6
0
6
0
0
6
0
7
0
0
6
0
8
0
0
6
0
9
0
0
6
1
0
0
0
6
1
1
0
0
6
1
2
0
0
6
1
3
0
0
6
1
4
0
0
6
1
5
0
0
6
1
6
0
0
6
1
7
0
0
6
1
8
0
0
6
1
9
0
0
6
2
0
0
0
6
2
1
0
0
6
2
2
0
0
6
2
3
0
0
6
2
4
0
0
6
2
5
Larynx
Inflammation, Chronic
Metaplasia, Squamous
Epiglottis, Fibrosis
Epiglottis, Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
3
2
3
3
3
3
3
3
2
3
3
3
1
3
3
3
3
3
3
3
2
1
3
3
2
3
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
+
1
+
1
+
2
+
+
2
+
2
+
2
+
2
+
2
+
2
3
+
+
2
1
+
2
+
2
+
2
+
2
+
1
+
2
2
3
+
2
2
3
+
1
2
+
2
1
2
+
2
1
+
2
3
2
+
1
3
+
2
3
2
1
2
Nose
Foreign Body
Inflammation, Acute
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
3
1
4
2
3
3
3
1
4
4
3
1
2
4
2
1
4
3
2
4
3
2
4
1
1
3
2
1
3
2
1
4
3
1
4
3
2
4
3
1
4
3
2
4
3
1
4
3
2
4
3
1
3
3
4
2
1
3
2
4
3
1
4
1
1
2
1
3
1
1
1
1
1
1
2
1
1
1
Trachea
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Eye
Cornea, Inflammation, Chronic Active
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Harderian Gland
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
3
3
males
(cont...)
4
SPECIAL SENSES SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 49
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
0
4
0
7
0
4
0
5
9
5
0
5
0
4
0
7
3
1
0
7
3
1
0
7
3
0
0
7
3
1
0
7
3
0
0
7
2
9
0
7
2
5
0
2
0
2
0
6
4
6
0
4
7
8
0
7
3
0
0
7
3
1
0
6
7
5
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
2
0
6
9
5
0
7
0
4
0
7
3
0
0
7
3
1
0
0
6
0
1
0
0
6
0
2
0
0
6
0
3
0
0
6
0
4
0
0
6
0
5
0
0
6
0
6
0
0
6
0
7
0
0
6
0
8
0
0
6
0
9
0
0
6
1
0
0
0
6
1
1
0
0
6
1
2
0
0
6
1
3
0
0
6
1
4
0
0
6
1
5
0
0
6
1
6
0
0
6
1
7
0
0
6
1
8
0
0
6
1
9
0
0
6
2
0
0
0
6
2
1
0
0
6
2
2
0
0
6
2
3
0
0
6
2
4
0
0
6
2
5
Hyperplasia
1
males
(cont...)
1
URINARY SYSTEM
Kidney
Infarct
Inflammation, Suppurative
Nephropathy
Renal Tubule, Hyperplasia
+
+
2
1
Urinary Bladder
Inflammation, Chronic Active
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
2
2
2
+
+
+
+
+
+
+
3
3
2
+
+
+
+
+
+
+
+
+
2
2
2
2
+
+
+
3
3
3
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 50
2
+
+
+
+
+
+
+
+
+
+
+
1
3
3
2
1
2
1
1
1
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
6
1
1
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
3
9
5
0
7
3
1
0
4
5
7
0
7
3
0
0
6
3
5
0
7
3
0
0
7
3
0
0
7
2
9
0
6
2
7
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
1
0
7
2
9
0
7
2
9
0
0
6
2
6
0
0
6
2
7
0
0
6
2
8
0
0
6
2
9
0
0
6
3
0
0
0
6
3
1
0
0
6
3
2
0
0
6
3
3
0
0
6
3
4
0
0
6
3
5
0
0
6
3
6
0
0
6
3
7
0
0
6
3
8
0
0
6
3
9
0
0
6
4
0
0
0
6
4
1
0
0
6
4
2
0
0
6
4
3
0
0
6
4
4
0
0
6
4
5
0
0
6
4
6
0
0
6
4
7
0
0
6
4
8
0
0
6
4
9
0
0
6
5
0
* TOTALS
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
48
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Small, Jejunum
Inflammation, Chronic
Lymphatic, Angiectasis
+
+
+
+
+
+
+
+
+
+
+
+
3
4
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Fatty Change
Mixed Cell Focus
Necrosis
Bile Duct, Dilatation
+
+
+
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
ALIMENTARY SYSTEM
X
+
X
X
X
+
+
+
X
X
+
+
2
+
1
+
+
X
X
X
X
+
+
X
+
+
+
+
+
X
X
X
X
X
X
X
X
X
+
X
+
+
2
X
+
+
1
X
50
7
18
26
1
1
1
4
X
2
X
3
Mesentery
Pancreas
Atrophy
+
1 3.0
1 4.0
+
+
+
1
1.4
2.0
1.0
3.5
2
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 51
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
50
5 1.2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
6
1
1
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
3
9
5
0
7
3
1
0
4
5
7
0
7
3
0
0
6
3
5
0
7
3
0
0
7
3
0
0
7
2
9
0
6
2
7
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
1
0
7
2
9
0
7
2
9
0
0
6
2
6
0
0
6
2
7
0
0
6
2
8
0
0
6
2
9
0
0
6
3
0
0
0
6
3
1
0
0
6
3
2
0
0
6
3
3
0
0
6
3
4
0
0
6
3
5
0
0
6
3
6
0
0
6
3
7
0
0
6
3
8
0
0
6
3
9
0
0
6
4
0
0
0
6
4
1
0
0
6
4
2
0
0
6
4
3
0
0
6
4
4
0
0
6
4
5
0
0
6
4
6
0
0
6
4
7
0
0
6
4
8
0
0
6
4
9
0
0
6
5
0
Basophilic Focus
* TOTALS
X
1
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Stomach, Forestomach
Hyperplasia, Squamous
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Stomach, Glandular
+
1 3.0
2 3.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Tooth
Dysplasia
50
1
1 2.0
CARDIOVASCULAR SYSTEM
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
+
+
+
+
1
+
1
+
1
+
1
+
1
+
+
2
+
+
1
+
+
1
+
+
+
1
+
1
+
+
1
+
+
1
+
1
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
2
3
2
2
2
2
2
2
+
2
2
2
2
2
2
2
+
+
+
+
+
+
+
33 1.2
ENDOCRINE SYSTEM
Adrenal Cortex
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
+
2
2
4
Adrenal Medulla
Angiectasis
Hyperplasia
+
+
+
4
2
+
2
+
+
+
+
+
+
+
+
+
+
+
+
2
50
2 1.5
26 2.2
16 2.1
2
+
+
+
50
1 3.0
1 3.0
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 52
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
6
1
1
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
3
9
5
0
7
3
1
0
4
5
7
0
7
3
0
0
6
3
5
0
7
3
0
0
7
3
0
0
7
2
9
0
6
2
7
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
1
0
7
2
9
0
7
2
9
0
0
6
2
6
0
0
6
2
7
0
0
6
2
8
0
0
6
2
9
0
0
6
3
0
0
0
6
3
1
0
0
6
3
2
0
0
6
3
3
0
0
6
3
4
0
0
6
3
5
0
0
6
3
6
0
0
6
3
7
0
0
6
3
8
0
0
6
3
9
0
0
6
4
0
0
0
6
4
1
0
0
6
4
2
0
0
6
4
3
0
0
6
4
4
0
0
6
4
5
0
0
6
4
6
0
0
6
4
7
0
0
6
4
8
0
0
6
4
9
0
0
6
5
0
* TOTALS
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Parathyroid Gland
Hyperplasia
+
+
+
+
+
M
+
+
+
2
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
47
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
+
2
+
2
+
Thyroid Gland
C-cell, Hyperplasia
+
+
2
+
+
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
+
+
+
+
+
+
+
+
1
+
+
1
+
2
+
+
1
+
1 2.0
+
2
+
+
1
+
+
2
3
+
+
+
4
+
2
+
+
2
+
1
+
2
+
+
+
+
1
+
+
1
+
1
+
+
+
2
2
+
+
1
+
1
+
50
16 1.9
4 2.3
+
2
50
28 1.5
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland
Inflammation, Chronic Active
1
1 3.0
Epididymis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Preputial Gland
Inflammation, Chronic Active
Duct, Ectasia
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Prostate
Hyperplasia
Inflammation, Chronic Active
+
3 2.7
1 3.0
3
+
+
2
+
+
1
+
+
+
+
+
2
+
+
+
+
2
+
+
+
+
3
+
2
+
+
+
+
3
+
2
+
50
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 53
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
11 2.1
2 2.5
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
6
1
1
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
3
9
5
0
7
3
1
0
4
5
7
0
7
3
0
0
6
3
5
0
7
3
0
0
7
3
0
0
7
2
9
0
6
2
7
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
1
0
7
2
9
0
7
2
9
0
0
6
2
6
0
0
6
2
7
0
0
6
2
8
0
0
6
2
9
0
0
6
3
0
0
0
6
3
1
0
0
6
3
2
0
0
6
3
3
0
0
6
3
4
0
0
6
3
5
0
0
6
3
6
0
0
6
3
7
0
0
6
3
8
0
0
6
3
9
0
0
6
4
0
0
0
6
4
1
0
0
6
4
2
0
0
6
4
3
0
0
6
4
4
0
0
6
4
5
0
0
6
4
6
0
0
6
4
7
0
0
6
4
8
0
0
6
4
9
0
0
6
5
0
* TOTALS
Seminal Vesicle
Hyperplasia
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Testes
Atrophy
Edema
Interstitial Cell, Hyperplasia
+
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
1 2.0
1 3.0
+
+
+
+
+
+
3
+
+
+
+
+
+
2
2
+
+
+
+
+
+
+
3
+
+
1
+
2
+
+
50
5 2.6
11 2.3
1 3.0
3
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node
Axillary, Ectasia
Iliac, Ectasia
Renal, Ectasia
+
+
+
+
+
+
+
50
+
1
5
+
35
1 1.0
1 3.0
2 2.5
1
Lymph Node, Bronchial
Ectasia
Hyperplasia, Lymphohistiocytic
+
+
+
1
+
4
2
1
4
Lymph Node, Mandibular
Hyperplasia, Lymphoid
+
M
+
+
Lymph Node, Mediastinal
Hyperplasia, Lymphohistiocytic
+
Lymph Node, Mesenteric
Hemorrhage
+
M
+
+
+
+
+
4
3
3
3
+
+
+
+
+
2
+
1
+
1
+
3
+
1
+
4
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
2
+
1
+
+
+
+
+
+
M
M
2
+
+
1
+
+
+
+
+
+
+
+
1
+
1
+
3
M
+
+
+
+
+
+
+
M
+
2
2
3
+
+
3
+
+
4
+
+
4
+
4
+
+
+
+
+
+
M
+
1 4.0
28 2.1
2
+
+
+
M
+
45
1 3.0
+
2
+
+
+
+
3
49
+
50
29 2.2
1 4.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 54
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
6
1
1
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
3
9
5
0
7
3
1
0
4
5
7
0
7
3
0
0
6
3
5
0
7
3
0
0
7
3
0
0
7
2
9
0
6
2
7
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
1
0
7
2
9
0
7
2
9
0
0
6
2
6
0
0
6
2
7
0
0
6
2
8
0
0
6
2
9
0
0
6
3
0
0
0
6
3
1
0
0
6
3
2
0
0
6
3
3
0
0
6
3
4
0
0
6
3
5
0
0
6
3
6
0
0
6
3
7
0
0
6
3
8
0
0
6
3
9
0
0
6
4
0
0
0
6
4
1
0
0
6
4
2
0
0
6
4
3
0
0
6
4
4
0
0
6
4
5
0
0
6
4
6
0
0
6
4
7
0
0
6
4
8
0
0
6
4
9
0
0
6
5
0
* TOTALS
Spleen
Angiectasis
Hematopoietic Cell Proliferation
+
+
2
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Thymus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
46
Mammary Gland
M
M
M
M
M
M
M
M
M
M
M
M
+
M
M
M
M
M
M
M
M
M
M
M
M
4
Skin
Angiectasis
Cyst Epithelial Inclusion
Inflammation, Chronic Active
Thrombosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
1 2.0
2 3.5
INTEGUMENTARY SYSTEM
3
4
4
2
4
1
3
4
1 3.0
1
22 3.5
1 3.0
MUSCULOSKELETAL SYSTEM
Bone
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
NERVOUS SYSTEM
Brain
Compression
1 2.0
Peripheral Nerve
+
+
6
Spinal Cord
+
+
6
RESPIRATORY SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 55
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
6
1
1
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
3
9
5
0
7
3
1
0
4
5
7
0
7
3
0
0
6
3
5
0
7
3
0
0
7
3
0
0
7
2
9
0
6
2
7
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
1
0
7
2
9
0
7
2
9
0
0
6
2
6
0
0
6
2
7
0
0
6
2
8
0
0
6
2
9
0
0
6
3
0
0
0
6
3
1
0
0
6
3
2
0
0
6
3
3
0
0
6
3
4
0
0
6
3
5
0
0
6
3
6
0
0
6
3
7
0
0
6
3
8
0
0
6
3
9
0
0
6
4
0
0
0
6
4
1
0
0
6
4
2
0
0
6
4
3
0
0
6
4
4
0
0
6
4
5
0
0
6
4
6
0
0
6
4
7
0
0
6
4
8
0
0
6
4
9
0
0
6
5
0
* TOTALS
Larynx
Inflammation, Chronic
Metaplasia, Squamous
Epiglottis, Fibrosis
Epiglottis, Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
3
3
3
2
3
3
3
3
2
3
3
+
2
2
2
3
3
3
3
3
2
2
3
3
3
2
3
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
+
1
+
1
4
1
+
1
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
1
+
2
+
+
2
3
+
2
+
2
+
2
+
2
+
2
1
+
2
+
2
1
+
2
50
2
2
3
+
2
2
2
+
2
4
2
+
1
3
1
Nose
Foreign Body
Inflammation, Acute
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
+
+
+
+
+
X
1
3
1
3
+
+
+
+
50
Trachea
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
3
1
4
+
3
1
3
3
3
3
2
3
1
1
1
+
+
+
+
Eye
Cornea, Inflammation, Chronic Active
Retina, Atrophy
+
+
+
+
Harderian Gland
+
3
1
4
2
+
3
2
3
2
1
3
+
2
1
4
+
2
2
4
+
3
+
+
1
2
3
1
3
3
1
3
+
3
1
4
2
1
3
3
2
3
3
1
1
1
1
3
2
3
3
3
3
3
1
3
1
1
50
34
50
1
29 1.2
3
1
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
50
+
+
2
3
1
3
+
1
2.0
2.7
1.0
3.0
47 1.8
13 2.4
19 2.0
3
1
4
3
3
1
3
2
1
50
1
1
1.0
2.6
1.3
3.5
SPECIAL SENSES SYSTEM
1 2.0
1 3.0
3
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 56
+
+
+
+
+
+
+
+
+
+
+
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS MALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
2
9
0
6
1
1
0
7
3
0
0
7
2
9
0
7
2
9
0
7
3
0
0
7
2
9
0
7
2
9
0
7
2
9
0
7
2
9
0
3
9
5
0
7
3
1
0
4
5
7
0
7
3
0
0
6
3
5
0
7
3
0
0
7
3
0
0
7
2
9
0
6
2
7
0
7
3
0
0
7
2
9
0
7
3
0
0
7
3
1
0
7
2
9
0
7
2
9
0
0
6
2
6
0
0
6
2
7
0
0
6
2
8
0
0
6
2
9
0
0
6
3
0
0
0
6
3
1
0
0
6
3
2
0
0
6
3
3
0
0
6
3
4
0
0
6
3
5
0
0
6
3
6
0
0
6
3
7
0
0
6
3
8
0
0
6
3
9
0
0
6
4
0
0
0
6
4
1
0
0
6
4
2
0
0
6
4
3
0
0
6
4
4
0
0
6
4
5
0
0
6
4
6
0
0
6
4
7
0
0
6
4
8
0
0
6
4
9
0
0
6
5
0
2
1
+
+
Hyperplasia
1
* TOTALS
1
6 1.2
URINARY SYSTEM
Kidney
Infarct
Inflammation, Suppurative
Nephropathy
Renal Tubule, Hyperplasia
+
+
1
1
2
Urinary Bladder
Inflammation, Chronic Active
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
50
1
4
38
3
2
1
+
+
+
+
2
2
3
3
+
+
+
+
1
+
+
+
3
2
2
1
2
3
1
2
1
1
2
3
+
+
+
+
+
+
+
+
+
+
I
+
4.0
2.3
1.9
1.3
49
1 3.0
1 3.0
*** END OF MALE DATA ***
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 57
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
5
9
9
0
7
3
2
0
6
1
0
0
7
3
2
0
7
3
1
0
6
9
0
0
7
3
1
0
7
3
1
0
7
3
2
0
7
1
2
0
7
3
1
0
7
3
1
0
5
8
6
0
7
3
3
0
7
3
1
0
6
4
5
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
1
0
6
9
8
0
7
0
3
0
7
3
3
0
0
1
0
1
0
0
1
0
2
0
0
1
0
3
0
0
1
0
4
0
0
1
0
5
0
0
1
0
6
0
0
1
0
7
0
0
1
0
8
0
0
1
0
9
0
0
1
1
0
0
0
1
1
1
0
0
1
1
2
0
0
1
1
3
0
0
1
1
4
0
0
1
1
5
0
0
1
1
6
0
0
1
1
7
0
0
1
1
8
0
0
1
1
9
0
0
1
2
0
0
0
1
2
1
0
0
1
2
2
0
0
1
2
3
0
0
1
2
4
0
0
1
2
5
Esophagus
Inflammation, Acute
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Colon
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Rectum
+
+
+
+
I
A
+
+
I
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Duodenum
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Ileum
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Jejunum
Diverticulum
Inflammation, Acute
Necrosis
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Fatty Change
Hematopoietic Cell Proliferation
Hepatodiaphragmatic Nodule
Mixed Cell Focus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
+
2
X
+
X
X
+
1
X
X
X
X
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
females
(cont...)
ALIMENTARY SYSTEM
X
2
X
X
X
X
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 58
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
5
9
9
0
7
3
2
0
6
1
0
0
7
3
2
0
7
3
1
0
6
9
0
0
7
3
1
0
7
3
1
0
7
3
2
0
7
1
2
0
7
3
1
0
7
3
1
0
5
8
6
0
7
3
3
0
7
3
1
0
6
4
5
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
1
0
6
9
8
0
7
0
3
0
7
3
3
0
0
1
0
1
0
0
1
0
2
0
0
1
0
3
0
0
1
0
4
0
0
1
0
5
0
0
1
0
6
0
0
1
0
7
0
0
1
0
8
0
0
1
0
9
0
0
1
1
0
0
0
1
1
1
0
0
1
1
2
0
0
1
1
3
0
0
1
1
4
0
0
1
1
5
0
0
1
1
6
0
0
1
1
7
0
0
1
1
8
0
0
1
1
9
0
0
1
2
0
0
0
1
2
1
0
0
1
2
2
0
0
1
2
3
0
0
1
2
4
0
0
1
2
5
Necrosis
Bile Duct, Cyst
Bile Duct, Dilatation
Bile Duct, Hyperplasia
Bile Duct, Inflammation, Chronic Active
X
3
Mesentery
Fat, Necrosis
1
+
2
+
2
+
2
+
2
2
+
2
Pancreas
Atrophy
+
2
+
+
+
+
A
+
+
+
1
+
+
+
1
+
+
+
+
2
+
+
+
+
+
+
+
+
+
Salivary Glands
Basophilic Focus
+
+
X
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Hyperplasia, Squamous
Inflammation, Acute
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
Inflammation, Acute
Mineralization
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Tongue
Inflammation, Granulomatous
females
(cont...)
1
+
2
CARDIOVASCULAR SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 59
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
5
9
9
0
7
3
2
0
6
1
0
0
7
3
2
0
7
3
1
0
6
9
0
0
7
3
1
0
7
3
1
0
7
3
2
0
7
1
2
0
7
3
1
0
7
3
1
0
5
8
6
0
7
3
3
0
7
3
1
0
6
4
5
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
1
0
6
9
8
0
7
0
3
0
7
3
3
0
0
1
0
1
0
0
1
0
2
0
0
1
0
3
0
0
1
0
4
0
0
1
0
5
0
0
1
0
6
0
0
1
0
7
0
0
1
0
8
0
0
1
0
9
0
0
1
1
0
0
0
1
1
1
0
0
1
1
2
0
0
1
1
3
0
0
1
1
4
0
0
1
1
5
0
0
1
1
6
0
0
1
1
7
0
0
1
1
8
0
0
1
1
9
0
0
1
2
0
0
0
1
2
1
0
0
1
2
2
0
0
1
2
3
0
0
1
2
4
0
0
1
2
5
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
Endocardium, Hyperplasia
+
+
+
+
+
1
+
1
+
+
+
1
+
1
+
+
+
1
+
+
+
+
1
+
1
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
4
2
2
2
1
1
2
1
2
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
females
(cont...)
3
ENDOCRINE SYSTEM
Adrenal Cortex
Accessory Adrenal Cortical Nodule
Angiectasis
Degeneration, Cystic
Hyperplasia
Hypertrophy
Necrosis
+
+
+
+
+
+
+
Adrenal Medulla
Hyperplasia
+
+
+
+
+
+
+
Islets, Pancreatic
+
+
+
+
+
A
Parathyroid Gland
+
+
+
+
+
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
+
2
+
+
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
+
2
+
3
+
2
+
+
+
+
2
3
+
+
+
+
+
+
+
2
2
2
2
2
3
3
2
2
2
2
2
+
+
+
+
3
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
2
+
+
+
+
+
+
+
+
+
1
+
+
2
+
2
+
+
2
+
1
+
3
+
+
+
+
2
+
+
1
+
2
+
3
+
1
+
+
3
+
4
+
3
2
2
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 60
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
5
9
9
0
7
3
2
0
6
1
0
0
7
3
2
0
7
3
1
0
6
9
0
0
7
3
1
0
7
3
1
0
7
3
2
0
7
1
2
0
7
3
1
0
7
3
1
0
5
8
6
0
7
3
3
0
7
3
1
0
6
4
5
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
1
0
6
9
8
0
7
0
3
0
7
3
3
0
0
1
0
1
0
0
1
0
2
0
0
1
0
3
0
0
1
0
4
0
0
1
0
5
0
0
1
0
6
0
0
1
0
7
0
0
1
0
8
0
0
1
0
9
0
0
1
1
0
0
0
1
1
1
0
0
1
1
2
0
0
1
1
3
0
0
1
1
4
0
0
1
1
5
0
0
1
1
6
0
0
1
1
7
0
0
1
1
8
0
0
1
1
9
0
0
1
2
0
0
0
1
2
1
0
0
1
2
2
0
0
1
2
3
0
0
1
2
4
0
0
1
2
5
Clitoral Gland
Inflammation, Chronic Active
+
+
2
+
+
2
+
+
+
+
+
+
+
+
+
3
+
+
3
+
+
+
+
+
+
+
+
3
+
+
Ovary
Cyst
+
2
+
+
+
3
+
+
+
+
+
+
+
+
X
+
+
+
1
+
+
2
+
+
2
+
+
+
3
+
+
+
Uterus
Cervix, Hypertrophy
Endometrium, Hyperplasia, Cystic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
1
2
+
+
+
+
+
+
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
females
(cont...)
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
2
4
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
Lymph Node
Lumbar, Pigmentation, Hemosiderin
Renal, Ectasia
Renal, Pigmentation, Hemosiderin
+
+
+
+
+
+
+
+
3
2
4
Lymph Node, Bronchial
+
M
M
+
+
+
+
+
+
+
+
M
+
+
M
+
+
+
+
+
+
M
+
+
+
Lymph Node, Mandibular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
Lymph Node, Mediastinal
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 61
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
5
9
9
0
7
3
2
0
6
1
0
0
7
3
2
0
7
3
1
0
6
9
0
0
7
3
1
0
7
3
1
0
7
3
2
0
7
1
2
0
7
3
1
0
7
3
1
0
5
8
6
0
7
3
3
0
7
3
1
0
6
4
5
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
1
0
6
9
8
0
7
0
3
0
7
3
3
0
0
1
0
1
0
0
1
0
2
0
0
1
0
3
0
0
1
0
4
0
0
1
0
5
0
0
1
0
6
0
0
1
0
7
0
0
1
0
8
0
0
1
0
9
0
0
1
1
0
0
0
1
1
1
0
0
1
1
2
0
0
1
1
3
0
0
1
1
4
0
0
1
1
5
0
0
1
1
6
0
0
1
1
7
0
0
1
1
8
0
0
1
1
9
0
0
1
2
0
0
0
1
2
1
0
0
1
2
2
0
0
1
2
3
0
0
1
2
4
0
0
1
2
5
Lymph Node, Mesenteric
Ectasia
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
Spleen
Hematopoietic Cell Proliferation
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Thymus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Mammary Gland
Galactocele
Hyperplasia
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Skin
Angiectasis
Inflammation, Chronic Active
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
females
(cont...)
INTEGUMENTARY SYSTEM
4
MUSCULOSKELETAL SYSTEM
Bone
Callus
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Brain
Meninges, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
Peripheral Nerve
+
NERVOUS SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 62
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
Spinal Cord
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
5
9
9
0
7
3
2
0
6
1
0
0
7
3
2
0
7
3
1
0
6
9
0
0
7
3
1
0
7
3
1
0
7
3
2
0
7
1
2
0
7
3
1
0
7
3
1
0
5
8
6
0
7
3
3
0
7
3
1
0
6
4
5
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
1
0
6
9
8
0
7
0
3
0
7
3
3
0
0
1
0
1
0
0
1
0
2
0
0
1
0
3
0
0
1
0
4
0
0
1
0
5
0
0
1
0
6
0
0
1
0
7
0
0
1
0
8
0
0
1
0
9
0
0
1
1
0
0
0
1
1
1
0
0
1
1
2
0
0
1
1
3
0
0
1
1
4
0
0
1
1
5
0
0
1
1
6
0
0
1
1
7
0
0
1
1
8
0
0
1
1
9
0
0
1
2
0
0
0
1
2
1
0
0
1
2
2
0
0
1
2
3
0
0
1
2
4
0
0
1
2
5
females
(cont...)
+
RESPIRATORY SYSTEM
Larynx
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Nose
Inflammation, Chronic Active
Thrombosis
Glands, Olfactory Epithelium, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
2
2
Trachea
+
+
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Eye
Retina, Atrophy
+
+
+
+
+
A
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Harderian Gland
Hyperplasia
+
+
1
+
+
+
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
1
+
+
+
+
1
1
2
SPECIAL SENSES SYSTEM
URINARY SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 63
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
5
9
9
0
7
3
2
0
6
1
0
0
7
3
2
0
7
3
1
0
6
9
0
0
7
3
1
0
7
3
1
0
7
3
2
0
7
1
2
0
7
3
1
0
7
3
1
0
5
8
6
0
7
3
3
0
7
3
1
0
6
4
5
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
1
0
6
9
8
0
7
0
3
0
7
3
3
0
0
1
0
1
0
0
1
0
2
0
0
1
0
3
0
0
1
0
4
0
0
1
0
5
0
0
1
0
6
0
0
1
0
7
0
0
1
0
8
0
0
1
0
9
0
0
1
1
0
0
0
1
1
1
0
0
1
1
2
0
0
1
1
3
0
0
1
1
4
0
0
1
1
5
0
0
1
1
6
0
0
1
1
7
0
0
1
1
8
0
0
1
1
9
0
0
1
2
0
0
0
1
2
1
0
0
1
2
2
0
0
1
2
3
0
0
1
2
4
0
0
1
2
5
Kidney
Inflammation, Suppurative
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
4
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
2
1
Urinary Bladder
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
1
1
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 64
1
+
+
+
+
+
1
+
+
+
+
females
(cont...)
1
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
3
2
0
4
9
9
0
7
3
3
0
6
1
0
0
7
3
1
0
7
3
2
0
6
1
9
0
7
3
2
0
7
3
2
0
7
3
2
0
4
0
2
0
7
3
1
0
7
3
3
0
6
1
9
0
7
3
2
0
7
3
3
0
7
0
3
0
7
3
3
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
0
9
0
7
3
3
0
0
1
2
6
0
0
1
2
7
0
0
1
2
8
0
0
1
2
9
0
0
1
3
0
0
0
1
3
1
0
0
1
3
2
0
0
1
3
3
0
0
1
3
4
0
0
1
3
5
0
0
1
3
6
0
0
1
3
7
0
0
1
3
8
0
0
1
3
9
0
0
1
4
0
0
0
1
4
1
0
0
1
4
2
0
0
1
4
3
0
0
1
4
4
0
0
1
4
5
0
0
1
4
6
0
0
1
4
7
0
0
1
4
8
0
0
1
4
9
0
0
1
5
0
* TOTALS
Esophagus
Inflammation, Acute
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
4
4
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
I
+
+
+
+
+
+
+
+
46
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Small, Jejunum
Diverticulum
Inflammation, Acute
Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Fatty Change
Hematopoietic Cell Proliferation
Hepatodiaphragmatic Nodule
Mixed Cell Focus
+
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
ALIMENTARY SYSTEM
1 4.0
1 4.0
1 2.0
1 4.0
1 4.0
4
4
X
X
+
+
+
X
+
+
X
+
3
X
+
+
+
X
X
+
2
X
X
+
+
X
+
+
+
X
X
+
+
X
X
X
+
+
+
+
X
X
X
+
+
+
50
X
X
2
2
X
X
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 65
X
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
4 2.0
34
14
1
3 2.3
1 2.0
1
2
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
3
2
0
4
9
9
0
7
3
3
0
6
1
0
0
7
3
1
0
7
3
2
0
6
1
9
0
7
3
2
0
7
3
2
0
7
3
2
0
4
0
2
0
7
3
1
0
7
3
3
0
6
1
9
0
7
3
2
0
7
3
3
0
7
0
3
0
7
3
3
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
0
9
0
7
3
3
0
0
1
2
6
0
0
1
2
7
0
0
1
2
8
0
0
1
2
9
0
0
1
3
0
0
0
1
3
1
0
0
1
3
2
0
0
1
3
3
0
0
1
3
4
0
0
1
3
5
0
0
1
3
6
0
0
1
3
7
0
0
1
3
8
0
0
1
3
9
0
0
1
4
0
0
0
1
4
1
0
0
1
4
2
0
0
1
4
3
0
0
1
4
4
0
0
1
4
5
0
0
1
4
6
0
0
1
4
7
0
0
1
4
8
0
0
1
4
9
0
0
1
5
0
Necrosis
Bile Duct, Cyst
Bile Duct, Dilatation
Bile Duct, Hyperplasia
Bile Duct, Inflammation, Chronic Active
* TOTALS
1
1
1
1
5
1
4
2
1
3
Mesentery
Fat, Necrosis
+
2
Pancreas
Atrophy
+
Salivary Glands
Basophilic Focus
+
Stomach, Forestomach
Hyperplasia, Squamous
Inflammation, Acute
Ulcer
+
Stomach, Glandular
Inflammation, Acute
Mineralization
Necrosis
+
+
+
+
2
+
+
+
+
+
1
+
+
+
+
+
+
1
+
+
+
1.0
4.0
1.8
3.0
7
7 2.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
6 1.3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
50
1 2.0
1 3.0
1 4.0
3
4
+
+
+
+
+
+
+
+
+
+
+
2
2
Tongue
Inflammation, Granulomatous
+
+
+
+
+
+
+
+
+
+
+
50
1 2.0
1 1.0
2 1.5
1
1
1 2.0
CARDIOVASCULAR SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 66
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
3
2
0
4
9
9
0
7
3
3
0
6
1
0
0
7
3
1
0
7
3
2
0
6
1
9
0
7
3
2
0
7
3
2
0
7
3
2
0
4
0
2
0
7
3
1
0
7
3
3
0
6
1
9
0
7
3
2
0
7
3
3
0
7
0
3
0
7
3
3
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
0
9
0
7
3
3
0
0
1
2
6
0
0
1
2
7
0
0
1
2
8
0
0
1
2
9
0
0
1
3
0
0
0
1
3
1
0
0
1
3
2
0
0
1
3
3
0
0
1
3
4
0
0
1
3
5
0
0
1
3
6
0
0
1
3
7
0
0
1
3
8
0
0
1
3
9
0
0
1
4
0
0
0
1
4
1
0
0
1
4
2
0
0
1
4
3
0
0
1
4
4
0
0
1
4
5
0
0
1
4
6
0
0
1
4
7
0
0
1
4
8
0
0
1
4
9
0
0
1
5
0
* TOTALS
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
Endocardium, Hyperplasia
+
1
+
+
+
1
+
+
1
+
+
+
+
+
1
+
+
1
+
1
+
+
+
+
+
+
+
1
+
+
+
1
+
50
Adrenal Cortex
Accessory Adrenal Cortical Nodule
Angiectasis
Degeneration, Cystic
Hyperplasia
Hypertrophy
Necrosis
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
2
2
2
2
2
2
3
Adrenal Medulla
Hyperplasia
+
+
1
+
+
+
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Parathyroid Gland
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
M
+
47
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
+
+
+
+
+
+
+
+
3
+
+
+
2
+
+
+
+
1
+
+
+
4
+
+
+
+
+
3
+
50
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
+
+
4
+
1
+
1
+
2
+
2
2
+
2
+
3
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
16 1.0
1 3.0
ENDOCRINE SYSTEM
+
2
2
+
3
2
2
+
+
+
2
+
+
+
+
2
3
+
3
2
2
4
+
+
+
1
2
+
+
+
+
1
+
+
3
2
+
+
+
+
+
3
3
+
+
2
2
2
2
3
2
2
+
+
+
50
1
1
26
17
14
1
49
2 2.0
8 2.4
1 2.0
2
+
3
+
1
+
2
+
1
+
2
+
2
1
+
1
3.0
2.0
2.3
2.1
2.1
2.0
+
1
+
1
+
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 67
+
+
+
+
1
+
1
+
1
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
37 1.9
2 1.5
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
3
2
0
4
9
9
0
7
3
3
0
6
1
0
0
7
3
1
0
7
3
2
0
6
1
9
0
7
3
2
0
7
3
2
0
7
3
2
0
4
0
2
0
7
3
1
0
7
3
3
0
6
1
9
0
7
3
2
0
7
3
3
0
7
0
3
0
7
3
3
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
0
9
0
7
3
3
0
0
1
2
6
0
0
1
2
7
0
0
1
2
8
0
0
1
2
9
0
0
1
3
0
0
0
1
3
1
0
0
1
3
2
0
0
1
3
3
0
0
1
3
4
0
0
1
3
5
0
0
1
3
6
0
0
1
3
7
0
0
1
3
8
0
0
1
3
9
0
0
1
4
0
0
0
1
4
1
0
0
1
4
2
0
0
1
4
3
0
0
1
4
4
0
0
1
4
5
0
0
1
4
6
0
0
1
4
7
0
0
1
4
8
0
0
1
4
9
0
0
1
5
0
* TOTALS
Clitoral Gland
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
50
Ovary
Cyst
+
+
+
3
+
Uterus
Cervix, Hypertrophy
Endometrium, Hyperplasia, Cystic
+
+
+
+
1
1
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
+
+
+
+
+
3
+
+
+
+
+
2
+
+
+
+
3
+
+
+
+
2
+
+
+
+
+
+
1
+
3
+
+
+
+
+
1
+
+
+
+
+
+
2
6 2.7
+
2
+
+
+
+
50
11 2.4
+
50
2 2.5
11 1.7
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node
Lumbar, Pigmentation, Hemosiderin
Renal, Ectasia
Renal, Pigmentation, Hemosiderin
50
2
1 3.0
1 2.0
1 4.0
Lymph Node, Bronchial
+
+
+
+
M
+
+
+
+
+
M
+
M
M
M
+
+
M
+
+
M
+
+
+
+
38
Lymph Node, Mandibular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Lymph Node, Mediastinal
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 68
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
3
2
0
4
9
9
0
7
3
3
0
6
1
0
0
7
3
1
0
7
3
2
0
6
1
9
0
7
3
2
0
7
3
2
0
7
3
2
0
4
0
2
0
7
3
1
0
7
3
3
0
6
1
9
0
7
3
2
0
7
3
3
0
7
0
3
0
7
3
3
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
0
9
0
7
3
3
0
0
1
2
6
0
0
1
2
7
0
0
1
2
8
0
0
1
2
9
0
0
1
3
0
0
0
1
3
1
0
0
1
3
2
0
0
1
3
3
0
0
1
3
4
0
0
1
3
5
0
0
1
3
6
0
0
1
3
7
0
0
1
3
8
0
0
1
3
9
0
0
1
4
0
0
0
1
4
1
0
0
1
4
2
0
0
1
4
3
0
0
1
4
4
0
0
1
4
5
0
0
1
4
6
0
0
1
4
7
0
0
1
4
8
0
0
1
4
9
0
0
1
5
0
* TOTALS
Lymph Node, Mesenteric
Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Spleen
Hematopoietic Cell Proliferation
+
Thymus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
M
Mammary Gland
Galactocele
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
3
2
+
+
+
+
+
+
+
+
2
+
+
+
Skin
Angiectasis
Inflammation, Chronic Active
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
1 3.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
50
+
+
+
48
+
+
+
50
1 4.0
INTEGUMENTARY SYSTEM
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3 2.3
1 2.0
+
+
+
+
+
50
1 4.0
2 3.5
3
MUSCULOSKELETAL SYSTEM
Bone
Callus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1 3.0
NERVOUS SYSTEM
Brain
Meninges, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1 1.0
Peripheral Nerve
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 69
2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
3
2
0
4
9
9
0
7
3
3
0
6
1
0
0
7
3
1
0
7
3
2
0
6
1
9
0
7
3
2
0
7
3
2
0
7
3
2
0
4
0
2
0
7
3
1
0
7
3
3
0
6
1
9
0
7
3
2
0
7
3
3
0
7
0
3
0
7
3
3
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
0
9
0
7
3
3
0
0
1
2
6
0
0
1
2
7
0
0
1
2
8
0
0
1
2
9
0
0
1
3
0
0
0
1
3
1
0
0
1
3
2
0
0
1
3
3
0
0
1
3
4
0
0
1
3
5
0
0
1
3
6
0
0
1
3
7
0
0
1
3
8
0
0
1
3
9
0
0
1
4
0
0
0
1
4
1
0
0
1
4
2
0
0
1
4
3
0
0
1
4
4
0
0
1
4
5
0
0
1
4
6
0
0
1
4
7
0
0
1
4
8
0
0
1
4
9
0
0
1
5
0
Spinal Cord
+
* TOTALS
2
RESPIRATORY SYSTEM
Larynx
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
Nose
Inflammation, Chronic Active
Thrombosis
Glands, Olfactory Epithelium, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
Trachea
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Eye
Retina, Atrophy
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
49
Harderian Gland
Hyperplasia
+
+
+
+
+
1 2.0
+
+
+
+
+
1
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
1
+
50
3 1.0
4 2.3
2
+
+
+
+
+
+
+
+
+
+
+
50
2
1
1
16
2
2
3
2
1
1
1
2
1
1
1
2
2
1
1.0
2.0
1.0
1.6
1 1.0
SPECIAL SENSES SYSTEM
+
+
+
2
+
+
+
2
+
+
+
+
+
3 1.3
+
+
+
+
+
+
+
+
+
49
3 1.7
URINARY SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 70
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
3
2
0
4
9
9
0
7
3
3
0
6
1
0
0
7
3
1
0
7
3
2
0
6
1
9
0
7
3
2
0
7
3
2
0
7
3
2
0
4
0
2
0
7
3
1
0
7
3
3
0
6
1
9
0
7
3
2
0
7
3
3
0
7
0
3
0
7
3
3
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
0
9
0
7
3
3
0
0
1
2
6
0
0
1
2
7
0
0
1
2
8
0
0
1
2
9
0
0
1
3
0
0
0
1
3
1
0
0
1
3
2
0
0
1
3
3
0
0
1
3
4
0
0
1
3
5
0
0
1
3
6
0
0
1
3
7
0
0
1
3
8
0
0
1
3
9
0
0
1
4
0
0
0
1
4
1
0
0
1
4
2
0
0
1
4
3
0
0
1
4
4
0
0
1
4
5
0
0
1
4
6
0
0
1
4
7
0
0
1
4
8
0
0
1
4
9
0
0
1
5
0
* TOTALS
Kidney
Inflammation, Suppurative
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1
1
Urinary Bladder
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
Control
ANIMAL ID
1
4
+
+
+
1
+
+
2
+
+
+
+
1
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 71
+
+
+
1
+
+
+
+
+
+
1 4.0
17 1.4
1 4.0
1
+
+
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
0
3
0
6
3
3
0
6
8
3
0
6
8
3
0
4
8
1
0
7
3
2
0
7
3
2
0
5
6
8
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
7
0
6
1
9
0
7
3
2
0
7
3
3
0
7
3
3
0
0
3
0
1
0
0
3
0
2
0
0
3
0
3
0
0
3
0
4
0
0
3
0
5
0
0
3
0
6
0
0
3
0
7
0
0
3
0
8
0
0
3
0
9
0
0
3
1
0
0
0
3
1
1
0
0
3
1
2
0
0
3
1
3
0
0
3
1
4
0
0
3
1
5
0
0
3
1
6
0
0
3
1
7
0
0
3
1
8
0
0
3
1
9
0
0
3
2
0
0
0
3
2
1
0
0
3
2
2
0
0
3
2
3
0
0
3
2
4
0
0
3
2
5
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
I
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Fatty Change
Necrosis
Bile Duct, Cyst
Bile Duct, Cyst, Multiple
Bile Duct, Hyperplasia
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
X
X
X
X
X
X
X
X
X
X
X
X
X
X
+
1
X
X
+
X
+
2
X
+
X
+
1
X
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
females
(cont...)
ALIMENTARY SYSTEM
X
2
3
X
1
Mesentery
Fat, Necrosis
Pancreas
Atrophy
X
X
1
+
2
+
+
+
+
3
+
+
+
+
+
2
+
+
+
+
3
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 72
+
+
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
0
3
0
6
3
3
0
6
8
3
0
6
8
3
0
4
8
1
0
7
3
2
0
7
3
2
0
5
6
8
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
7
0
6
1
9
0
7
3
2
0
7
3
3
0
7
3
3
0
0
3
0
1
0
0
3
0
2
0
0
3
0
3
0
0
3
0
4
0
0
3
0
5
0
0
3
0
6
0
0
3
0
7
0
0
3
0
8
0
0
3
0
9
0
0
3
1
0
0
0
3
1
1
0
0
3
1
2
0
0
3
1
3
0
0
3
1
4
0
0
3
1
5
0
0
3
1
6
0
0
3
1
7
0
0
3
1
8
0
0
3
1
9
0
0
3
2
0
0
0
3
2
1
0
0
3
2
2
0
0
3
2
3
0
0
3
2
4
0
0
3
2
5
Salivary Glands
Basophilic Focus
+
+
+
+
+
+
+
+
X
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Inflammation, Chronic Active
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
Stomach, Glandular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
+
1
+
+
+
1
+
1
+
+
1
+
+
1
+
+
+
1
+
+
1
+
1
+
+
1
+
+
+
1
+
1
+
+
+
+
Adrenal Cortex
Angiectasis
Degeneration, Cystic
Hyperplasia
Hypertrophy
Metaplasia, Osseous
Necrosis
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
3
2
3
2
2
2
2
2
2
2
2
Adrenal Medulla
Hyperplasia
+
2
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
females
(cont...)
Basophilic Focus
CARDIOVASCULAR SYSTEM
ENDOCRINE SYSTEM
2
2
+
+
2
+
+
2
+
+
3
2
3
2
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 73
+
+
+
2
2
+
+
+
2
2
2
2
2
2
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
0
3
0
6
3
3
0
6
8
3
0
6
8
3
0
4
8
1
0
7
3
2
0
7
3
2
0
5
6
8
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
7
0
6
1
9
0
7
3
2
0
7
3
3
0
7
3
3
0
0
3
0
1
0
0
3
0
2
0
0
3
0
3
0
0
3
0
4
0
0
3
0
5
0
0
3
0
6
0
0
3
0
7
0
0
3
0
8
0
0
3
0
9
0
0
3
1
0
0
0
3
1
1
0
0
3
1
2
0
0
3
1
3
0
0
3
1
4
0
0
3
1
5
0
0
3
1
6
0
0
3
1
7
0
0
3
1
8
0
0
3
1
9
0
0
3
2
0
0
0
3
2
1
0
0
3
2
2
0
0
3
2
3
0
0
3
2
4
0
0
3
2
5
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Parathyroid Gland
+
+
+
+
+
M
+
+
+
M
M
+
+
+
+
M
+
+
+
+
+
+
+
+
M
Pituitary Gland
Pars Distalis, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
2
+
+
1
+
2
+
+
1
+
+
+
2
+
+
+
+
2
+
+
Thyroid Gland
C-cell, Hyperplasia
+
1
+
3
+
3
+
3
+
2
+
1
+
2
+
2
+
1
+
3
+
1
+
1
+
2
+
2
+
4
+
2
+
2
+
2
+
3
+
1
+
+
2
+
1
+
2
+
1
Clitoral Gland
Inflammation, Chronic Active
+
+
4
+
+
3
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
I
+
M
+
+
M
+
Ovary
Cyst
+
4
+
+
+
3
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
Uterus
Endometrium, Hyperplasia, Cystic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
4
+
+
+
+
+
4
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
females
(cont...)
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Vagina
+
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 74
+
+
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
0
3
0
6
3
3
0
6
8
3
0
6
8
3
0
4
8
1
0
7
3
2
0
7
3
2
0
5
6
8
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
7
0
6
1
9
0
7
3
2
0
7
3
3
0
7
3
3
0
0
3
0
1
0
0
3
0
2
0
0
3
0
3
0
0
3
0
4
0
0
3
0
5
0
0
3
0
6
0
0
3
0
7
0
0
3
0
8
0
0
3
0
9
0
0
3
1
0
0
0
3
1
1
0
0
3
1
2
0
0
3
1
3
0
0
3
1
4
0
0
3
1
5
0
0
3
1
6
0
0
3
1
7
0
0
3
1
8
0
0
3
1
9
0
0
3
2
0
0
0
3
2
1
0
0
3
2
2
0
0
3
2
3
0
0
3
2
4
0
0
3
2
5
Lymph Node
Lumbar, Ectasia
Lumbar, Hemorrhage
+
2
females
(cont...)
+
3
Lymph Node, Bronchial
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
M
+
M
M
+
+
+
Lymph Node, Mandibular
Ectasia
+
+
+
M
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Mediastinal
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
Lymph Node, Mesenteric
Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Spleen
Hematopoietic Cell Proliferation
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
Thymus
Hyperplasia, Tubular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
Mammary Gland
Galactocele
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
Skin
Inflammation, Chronic Active
Subcutaneous Tissue, Hemorrhage
Subcutaneous Tissue, Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
INTEGUMENTARY SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 75
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
0
3
0
6
3
3
0
6
8
3
0
6
8
3
0
4
8
1
0
7
3
2
0
7
3
2
0
5
6
8
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
7
0
6
1
9
0
7
3
2
0
7
3
3
0
7
3
3
0
0
3
0
1
0
0
3
0
2
0
0
3
0
3
0
0
3
0
4
0
0
3
0
5
0
0
3
0
6
0
0
3
0
7
0
0
3
0
8
0
0
3
0
9
0
0
3
1
0
0
0
3
1
1
0
0
3
1
2
0
0
3
1
3
0
0
3
1
4
0
0
3
1
5
0
0
3
1
6
0
0
3
1
7
0
0
3
1
8
0
0
3
1
9
0
0
3
2
0
0
0
3
2
1
0
0
3
2
2
0
0
3
2
3
0
0
3
2
4
0
0
3
2
5
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
females
(cont...)
MUSCULOSKELETAL SYSTEM
Bone
Skeletal Muscle
+
NERVOUS SYSTEM
Brain
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Peripheral Nerve
+
+
+
+
Spinal Cord
+
+
+
+
RESPIRATORY SYSTEM
Larynx
Metaplasia, Squamous
+
1
+
2
+
2
+
1
+
2
+
2
+
2
+
2
+
2
+
2
+
1
+
1
+
3
+
2
+
2
+
2
+
1
+
2
+
2
+
1
+
1
+
2
+
1
+
1
+
2
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
+
1
1
+
+
+
+
+
+
+
+
1
+
1
+
+
+
+
+
+
1
+
1
4
+
+
+
+
1
1
+
1
+
+
Nose
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
1
+
2
+
+
1
+
+
1
+
1
+
1
+
2
3
2
3
3
2
2
+
3
1
3
+
3
+
2
1
3
+
2
+
2
1
3
+
2
+
2
1
2
+
2
+
2
1
3
+
2
3
+
2
1
3
+
2
2
+
1
1
2
+
1
1
3
+
2
1
4
3
1
3
1
1
1
1
1
1
1
1
1
3
1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 76
1
1
1
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
3
0
7
0
3
0
6
3
3
0
6
8
3
0
6
8
3
0
4
8
1
0
7
3
2
0
7
3
2
0
5
6
8
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
7
0
6
1
9
0
7
3
2
0
7
3
3
0
7
3
3
0
0
3
0
1
0
0
3
0
2
0
0
3
0
3
0
0
3
0
4
0
0
3
0
5
0
0
3
0
6
0
0
3
0
7
0
0
3
0
8
0
0
3
0
9
0
0
3
1
0
0
0
3
1
1
0
0
3
1
2
0
0
3
1
3
0
0
3
1
4
0
0
3
1
5
0
0
3
1
6
0
0
3
1
7
0
0
3
1
8
0
0
3
1
9
0
0
3
2
0
0
0
3
2
1
0
0
3
2
2
0
0
3
2
3
0
0
3
2
4
0
0
3
2
5
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Eye
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
Harderian Gland
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
+
+
1
+
+
Kidney
Cyst
Hydronephrosis
Inflammation, Suppurative
Mineralization
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
+
+
1
1
1
1
Urinary Bladder
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
Trachea
females
(cont...)
SPECIAL SENSES SYSTEM
URINARY SYSTEM
3
2
2
1
3
1
1
2
1
1
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 77
+
+
+
+
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
6
2
7
0
7
3
2
0
6
0
3
0
7
3
1
0
7
2
9
0
7
3
1
0
6
3
3
0
5
3
0
0
7
3
2
0
7
3
1
0
7
3
1
0
6
5
3
0
5
3
0
0
6
8
1
0
6
8
4
0
7
3
2
0
5
4
4
0
7
3
2
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
0
3
2
6
0
0
3
2
7
0
0
3
2
8
0
0
3
2
9
0
0
3
3
0
0
0
3
3
1
0
0
3
3
2
0
0
3
3
3
0
0
3
3
4
0
0
3
3
5
0
0
3
3
6
0
0
3
3
7
0
0
3
3
8
0
0
3
3
9
0
0
3
4
0
0
0
3
4
1
0
0
3
4
2
0
0
3
4
3
0
0
3
4
4
0
0
3
4
5
0
0
3
4
6
0
0
3
4
7
0
0
3
4
8
0
0
3
4
9
0
0
3
5
0
* TOTALS
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Fatty Change
Necrosis
Bile Duct, Cyst
Bile Duct, Cyst, Multiple
Bile Duct, Hyperplasia
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
X
X
X
X
X
X
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
ALIMENTARY SYSTEM
X
X
X
X
5
33
6
1
1
1
4
2
X
X
X
Mesentery
Fat, Necrosis
Pancreas
Atrophy
X
X
+
2
+
+
+
+
+
2
+
+
+
+
+
+
+
2
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 78
+
+
+
2
+
+
+
1
+
+
+
1.2
2.0
3.0
1.0
8
8 2.3
+
1
+
1
+
+
+
1
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
4 1.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
6
2
7
0
7
3
2
0
6
0
3
0
7
3
1
0
7
2
9
0
7
3
1
0
6
3
3
0
5
3
0
0
7
3
2
0
7
3
1
0
7
3
1
0
6
5
3
0
5
3
0
0
6
8
1
0
6
8
4
0
7
3
2
0
5
4
4
0
7
3
2
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
0
3
2
6
0
0
3
2
7
0
0
3
2
8
0
0
3
2
9
0
0
3
3
0
0
0
3
3
1
0
0
3
3
2
0
0
3
3
3
0
0
3
3
4
0
0
3
3
5
0
0
3
3
6
0
0
3
3
7
0
0
3
3
8
0
0
3
3
9
0
0
3
4
0
0
0
3
4
1
0
0
3
4
2
0
0
3
4
3
0
0
3
4
4
0
0
3
4
5
0
0
3
4
6
0
0
3
4
7
0
0
3
4
8
0
0
3
4
9
0
0
3
5
0
Basophilic Focus
* TOTALS
X
+
1
Salivary Glands
Basophilic Focus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Stomach, Forestomach
Inflammation, Chronic Active
Ulcer
+
Stomach, Glandular
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
+
+
+
+
+
+
+
+
+
+
2
+
+
1
+
1
+
+
+
1
+
1
+
+
+
+
1
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
2
1
2
3
2
2
4
2
2
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1 4.0
1 4.0
4
CARDIOVASCULAR SYSTEM
17 1.1
ENDOCRINE SYSTEM
Adrenal Cortex
Angiectasis
Degeneration, Cystic
Hyperplasia
Hypertrophy
Metaplasia, Osseous
Necrosis
+
Adrenal Medulla
Hyperplasia
+
+
+
+
1
2
3
2
2
2
+
+
+
2
2
+
+
2
2
2
2
+
1
2
2
2
2
2
2
+
+
+
2
1
3
2
2
2
+
+
+
2
50
1
23
20
20
1
1
2
3
2
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 79
+
+
+
+
+
+
+
+
+
2.0
2.1
2.0
2.1
3.0
2.0
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
2 2.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
6
2
7
0
7
3
2
0
6
0
3
0
7
3
1
0
7
2
9
0
7
3
1
0
6
3
3
0
5
3
0
0
7
3
2
0
7
3
1
0
7
3
1
0
6
5
3
0
5
3
0
0
6
8
1
0
6
8
4
0
7
3
2
0
5
4
4
0
7
3
2
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
0
3
2
6
0
0
3
2
7
0
0
3
2
8
0
0
3
2
9
0
0
3
3
0
0
0
3
3
1
0
0
3
3
2
0
0
3
3
3
0
0
3
3
4
0
0
3
3
5
0
0
3
3
6
0
0
3
3
7
0
0
3
3
8
0
0
3
3
9
0
0
3
4
0
0
0
3
4
1
0
0
3
4
2
0
0
3
4
3
0
0
3
4
4
0
0
3
4
5
0
0
3
4
6
0
0
3
4
7
0
0
3
4
8
0
0
3
4
9
0
0
3
5
0
* TOTALS
Islets, Pancreatic
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Parathyroid Gland
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
44
Pituitary Gland
Pars Distalis, Hyperplasia
+
2
+
2
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
3
+
+
+
3
+
+
+
+
50
Thyroid Gland
C-cell, Hyperplasia
+
1
+
2
+
1
+
1
+
+
3
+
1
+
+
2
+
2
+
1
+
2
+
1
50
Clitoral Gland
Inflammation, Chronic Active
+
+
+
M
+
+
+
+
+
+
+
+
+
2
46
Ovary
Cyst
+
+
2
50
Uterus
Endometrium, Hyperplasia, Cystic
+
+
50
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
+
2
+
2
+
1
+
1
+
+
+
+
+
+
+
+
1
+
3
+
1
+
1
+
1
+
+
+
+
+
+
+
11 2.0
44 1.8
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
3
+
3
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
4 3.0
9 2.9
4 3.0
Vagina
1
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 80
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
6
2
7
0
7
3
2
0
6
0
3
0
7
3
1
0
7
2
9
0
7
3
1
0
6
3
3
0
5
3
0
0
7
3
2
0
7
3
1
0
7
3
1
0
6
5
3
0
5
3
0
0
6
8
1
0
6
8
4
0
7
3
2
0
5
4
4
0
7
3
2
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
0
3
2
6
0
0
3
2
7
0
0
3
2
8
0
0
3
2
9
0
0
3
3
0
0
0
3
3
1
0
0
3
3
2
0
0
3
3
3
0
0
3
3
4
0
0
3
3
5
0
0
3
3
6
0
0
3
3
7
0
0
3
3
8
0
0
3
3
9
0
0
3
4
0
0
0
3
4
1
0
0
3
4
2
0
0
3
4
3
0
0
3
4
4
0
0
3
4
5
0
0
3
4
6
0
0
3
4
7
0
0
3
4
8
0
0
3
4
9
0
0
3
5
0
Lymph Node
Lumbar, Ectasia
Lumbar, Hemorrhage
* TOTALS
2
1 2.0
1 3.0
Lymph Node, Bronchial
+
M
+
M
+
+
M
+
M
+
+
M
+
+
+
+
+
M
+
M
+
M
M
+
M
35
Lymph Node, Mandibular
Ectasia
M
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
47
Lymph Node, Mediastinal
+
+
+
+
+
+
+
+
+
+
M
M
+
+
+
+
+
+
+
+
+
+
M
+
+
46
Lymph Node, Mesenteric
Ectasia
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Spleen
Hematopoietic Cell Proliferation
+
+
+
Thymus
Hyperplasia, Tubular
+
+
1 3.0
+
+
+
+
+
+
1 2.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
2 3.5
+
+
+
+
+
+
+
+
+
+
M
M
+
+
+
+
+
+
+
+
+
+
+
+
48
1 2.0
INTEGUMENTARY SYSTEM
Mammary Gland
Galactocele
+
Skin
Inflammation, Chronic Active
Subcutaneous Tissue, Hemorrhage
Subcutaneous Tissue, Necrosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1 2.0
+
+
4
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
4
+
+
+
+
50
1
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 81
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
4 3.3
1 1.0
1 3.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
6
2
7
0
7
3
2
0
6
0
3
0
7
3
1
0
7
2
9
0
7
3
1
0
6
3
3
0
5
3
0
0
7
3
2
0
7
3
1
0
7
3
1
0
6
5
3
0
5
3
0
0
6
8
1
0
6
8
4
0
7
3
2
0
5
4
4
0
7
3
2
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
0
3
2
6
0
0
3
2
7
0
0
3
2
8
0
0
3
2
9
0
0
3
3
0
0
0
3
3
1
0
0
3
3
2
0
0
3
3
3
0
0
3
3
4
0
0
3
3
5
0
0
3
3
6
0
0
3
3
7
0
0
3
3
8
0
0
3
3
9
0
0
3
4
0
0
0
3
4
1
0
0
3
4
2
0
0
3
4
3
0
0
3
4
4
0
0
3
4
5
0
0
3
4
6
0
0
3
4
7
0
0
3
4
8
0
0
3
4
9
0
0
3
5
0
* TOTALS
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
MUSCULOSKELETAL SYSTEM
Bone
Skeletal Muscle
1
NERVOUS SYSTEM
Brain
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Peripheral Nerve
+
+
+
+
+
9
Spinal Cord
+
+
+
+
+
9
RESPIRATORY SYSTEM
Larynx
Metaplasia, Squamous
+
1
+
2
+
1
+
2
+
1
+
1
+
1
+
2
+
2
+
2
+
2
+
2
+
3
+
1
+
2
+
1
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
1
50
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
+
1
+
1
+
+
+
+
1
+
1
+
+
1
+
1
+
+
+
+
+
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
+
50
Nose
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
2
+
+
+
1
+
+
+
1
1
3
+
2
+
1
1
2
+
2
2
+
1
1
4
+
1
2
+
2
1
3
+
2
1
3
+
1
1
4
+
1
2
+
2
1
4
3
2
2
1
2
1
1
1
2
1
3
+
2
+
2
1
3
1
2
1
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 82
+
1
3
+
2
1
3
+
+
1
4
1
2
1
1
1
2
1
50 1.7
20 1.0
3 2.0
+
1
50
2
32 1.6
25 1.0
50 2.6
1
24 1.1
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
6
2
7
0
7
3
2
0
6
0
3
0
7
3
1
0
7
2
9
0
7
3
1
0
6
3
3
0
5
3
0
0
7
3
2
0
7
3
1
0
7
3
1
0
6
5
3
0
5
3
0
0
6
8
1
0
6
8
4
0
7
3
2
0
5
4
4
0
7
3
2
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
2
0
7
3
1
0
0
3
2
6
0
0
3
2
7
0
0
3
2
8
0
0
3
2
9
0
0
3
3
0
0
0
3
3
1
0
0
3
3
2
0
0
3
3
3
0
0
3
3
4
0
0
3
3
5
0
0
3
3
6
0
0
3
3
7
0
0
3
3
8
0
0
3
3
9
0
0
3
4
0
0
0
3
4
1
0
0
3
4
2
0
0
3
4
3
0
0
3
4
4
0
0
3
4
5
0
0
3
4
6
0
0
3
4
7
0
0
3
4
8
0
0
3
4
9
0
0
3
5
0
* TOTALS
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Eye
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
2
+
+
+
+
+
2
+
+
+
50
Harderian Gland
Hyperplasia
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
10 mg/m3
ANIMAL ID
Trachea
SPECIAL SENSES SYSTEM
+
+
+
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
4 2.0
+
+
50
3 1.0
URINARY SYSTEM
Kidney
Cyst
Hydronephrosis
Inflammation, Suppurative
Mineralization
Nephropathy
Transitional Epithelium, Hyperplasia
+
Urinary Bladder
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1
1
2
1
16
3
1
1
1
+
+
1
1
+
1
1
1
1
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 83
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
4.0
3.0
1.5
2.0
1.2
1.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
6
7
3
0
7
0
8
0
6
9
0
0
7
3
2
0
7
3
1
0
6
6
0
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
3
0
7
3
1
0
7
3
1
0
5
9
8
0
7
3
3
0
7
3
1
0
6
4
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
1
9
0
7
3
2
0
0
5
0
1
0
0
5
0
2
0
0
5
0
3
0
0
5
0
4
0
0
5
0
5
0
0
5
0
6
0
0
5
0
7
0
0
5
0
8
0
0
5
0
9
0
0
5
1
0
0
0
5
1
1
0
0
5
1
2
0
0
5
1
3
0
0
5
1
4
0
0
5
1
5
0
0
5
1
6
0
0
5
1
7
0
0
5
1
8
0
0
5
1
9
0
0
5
2
0
0
0
5
2
1
0
0
5
2
2
0
0
5
2
3
0
0
5
2
4
0
0
5
2
5
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
I
+
+
+
+
+
+
+
+
+
+
+
I
+
+
+
Intestine Small, Duodenum
Muscularis, Hypertrophy, Focal
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Small, Jejunum
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Fatty Change
Hepatodiaphragmatic Nodule
Necrosis
Bile Duct, Cyst, Multiple
Bile Duct, Dilatation
Bile Duct, Hyperplasia
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
X
X
X
X
X
X
X
X
+
2
X
X
+
X
+
2
X
X
X
X
X
X
X
+
1
X
X
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
females
(cont...)
ALIMENTARY SYSTEM
Mesentery
X
X
X
X
X
X
1
2
X
1
X
4
4
2
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 84
2
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
6
7
3
0
7
0
8
0
6
9
0
0
7
3
2
0
7
3
1
0
6
6
0
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
3
0
7
3
1
0
7
3
1
0
5
9
8
0
7
3
3
0
7
3
1
0
6
4
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
1
9
0
7
3
2
0
0
5
0
1
0
0
5
0
2
0
0
5
0
3
0
0
5
0
4
0
0
5
0
5
0
0
5
0
6
0
0
5
0
7
0
0
5
0
8
0
0
5
0
9
0
0
5
1
0
0
0
5
1
1
0
0
5
1
2
0
0
5
1
3
0
0
5
1
4
0
0
5
1
5
0
0
5
1
6
0
0
5
1
7
0
0
5
1
8
0
0
5
1
9
0
0
5
2
0
0
0
5
2
1
0
0
5
2
2
0
0
5
2
3
0
0
5
2
4
0
0
5
2
5
Fat, Necrosis
2
2
2
2
2
females
(cont...)
2
Pancreas
Atrophy
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Inflammation, Acute
Inflammation, Chronic Active
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
2
+
Stomach, Glandular
Mineralization
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
+
+
+
+
+
+
+
+
1
+
+
+
1
+
+
+
+
1
+
1
+
+
+
+
+
+
1
+
1
+
+
1
Adrenal Cortex
Angiectasis
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
3
1
2
2
2
2
2
3
2
3
2
2
1
1
2
2
2
2
Adrenal Medulla
+
+
+
+
+
+
+
3
CARDIOVASCULAR SYSTEM
ENDOCRINE SYSTEM
1
3
2
2
2
2
+
+
+
+
+
+
+
M
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 85
+
2
3
2
2
+
+
+
3
2
2
2
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
6
7
3
0
7
0
8
0
6
9
0
0
7
3
2
0
7
3
1
0
6
6
0
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
3
0
7
3
1
0
7
3
1
0
5
9
8
0
7
3
3
0
7
3
1
0
6
4
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
1
9
0
7
3
2
0
0
5
0
1
0
0
5
0
2
0
0
5
0
3
0
0
5
0
4
0
0
5
0
5
0
0
5
0
6
0
0
5
0
7
0
0
5
0
8
0
0
5
0
9
0
0
5
1
0
0
0
5
1
1
0
0
5
1
2
0
0
5
1
3
0
0
5
1
4
0
0
5
1
5
0
0
5
1
6
0
0
5
1
7
0
0
5
1
8
0
0
5
1
9
0
0
5
2
0
0
0
5
2
1
0
0
5
2
2
0
0
5
2
3
0
0
5
2
4
0
0
5
2
5
Hyperplasia
females
(cont...)
2
Islets, Pancreatic
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Parathyroid Gland
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
M
+
+
M
+
M
+
Pituitary Gland
Pars Distalis, Hyperplasia
+
+
+
+
+
3
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
2
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
2
+
3
+
1
+
3
+
3
+
2
+
3
+
+
3
+
2
+
1
+
2
+
2
+
1
+
3
+
3
+
2
+
1
+
+
4
+
3
+
2
+
2
+
2
+
1
Clitoral Gland
Inflammation, Chronic
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Ovary
Cyst
+
+
+
+
+
+
2
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Uterus
Adenomyosis
Cervix, Cyst, Squamous
Cervix, Hypertrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 86
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
6
7
3
0
7
0
8
0
6
9
0
0
7
3
2
0
7
3
1
0
6
6
0
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
3
0
7
3
1
0
7
3
1
0
5
9
8
0
7
3
3
0
7
3
1
0
6
4
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
1
9
0
7
3
2
0
0
5
0
1
0
0
5
0
2
0
0
5
0
3
0
0
5
0
4
0
0
5
0
5
0
0
5
0
6
0
0
5
0
7
0
0
5
0
8
0
0
5
0
9
0
0
5
1
0
0
0
5
1
1
0
0
5
1
2
0
0
5
1
3
0
0
5
1
4
0
0
5
1
5
0
0
5
1
6
0
0
5
1
7
0
0
5
1
8
0
0
5
1
9
0
0
5
2
0
0
0
5
2
1
0
0
5
2
2
0
0
5
2
3
0
0
5
2
4
0
0
5
2
5
Endometrium, Hyperplasia, Cystic
2
2
females
(cont...)
3
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Bronchial
Hyperplasia, Lymphohistiocytic
+
+
+
M
+
M
M
M
M
M
+
1
+
+
1
+
+
1
+
+
+
+
+
2
+
M
+
M
+
Lymph Node, Mandibular
+
+
+
+
+
+
+
M
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Mediastinal
Hemorrhage
Hyperplasia, Lymphohistiocytic
+
+
+
2
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Mesenteric
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Spleen
Hematopoietic Cell Proliferation
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Thymus
Cyst
+
+
+
+
I
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node
Lumbar, Hyperplasia, Lymphoid
1
INTEGUMENTARY SYSTEM
Mammary Gland
Galactocele
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 87
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
Skin
Inflammation, Chronic Active
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
6
7
3
0
7
0
8
0
6
9
0
0
7
3
2
0
7
3
1
0
6
6
0
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
3
0
7
3
1
0
7
3
1
0
5
9
8
0
7
3
3
0
7
3
1
0
6
4
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
1
9
0
7
3
2
0
0
5
0
1
0
0
5
0
2
0
0
5
0
3
0
0
5
0
4
0
0
5
0
5
0
0
5
0
6
0
0
5
0
7
0
0
5
0
8
0
0
5
0
9
0
0
5
1
0
0
0
5
1
1
0
0
5
1
2
0
0
5
1
3
0
0
5
1
4
0
0
5
1
5
0
0
5
1
6
0
0
5
1
7
0
0
5
1
8
0
0
5
1
9
0
0
5
2
0
0
0
5
2
1
0
0
5
2
2
0
0
5
2
3
0
0
5
2
4
0
0
5
2
5
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
+
+
3
+
+
+
3
+
+
+
+
+
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
females
(cont...)
MUSCULOSKELETAL SYSTEM
Bone
NERVOUS SYSTEM
Brain
Peripheral Nerve
+
+
+
Spinal Cord
+
+
+
RESPIRATORY SYSTEM
Larynx
Metaplasia, Squamous
+
3
+
3
+
3
+
3
+
3
+
3
+
2
+
3
+
3
+
2
+
2
+
1
+
3
+
2
+
3
+
1
+
2
+
3
+
3
+
2
+
3
+
3
+
3
+
2
+
2
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
+
1
+
+
+
1
+
1
+
1
+
1
+
+
1
Nose
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
+
+
2
1
3
1
1
2
3
+
1
2
2
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
1
3
2
2
1
2
2
1
4
2
1
3
1
1
3
3
1
3
2
1
2
1
2
1
2
1
1
2
1
1
1
3
2
2
1
1
3
2
1
4
1
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 88
2
3
3
3
3
+
2
+
+
+
2
3
1
4
2
1
4
3
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
6
7
3
0
7
0
8
0
6
9
0
0
7
3
2
0
7
3
1
0
6
6
0
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
7
3
1
0
6
8
3
0
7
3
1
0
7
3
1
0
5
9
8
0
7
3
3
0
7
3
1
0
6
4
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
1
9
0
7
3
2
0
0
5
0
1
0
0
5
0
2
0
0
5
0
3
0
0
5
0
4
0
0
5
0
5
0
0
5
0
6
0
0
5
0
7
0
0
5
0
8
0
0
5
0
9
0
0
5
1
0
0
0
5
1
1
0
0
5
1
2
0
0
5
1
3
0
0
5
1
4
0
0
5
1
5
0
0
5
1
6
0
0
5
1
7
0
0
5
1
8
0
0
5
1
9
0
0
5
2
0
0
0
5
2
1
0
0
5
2
2
0
0
5
2
3
0
0
5
2
4
0
0
5
2
5
1
1
1
1
1
1
1
1
1
1
1
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Eye
Cataract
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
Harderian Gland
Hyperplasia
+
+
+
+
1
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
Kidney
Cyst
Nephropathy
Transitional Epithelium, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
1
1
1
+
2
2
2
2
Urinary Bladder
+
+
+
+
+
+
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
Respiratory Epithelium, Accumulation, Hyaline
Droplet
Trachea
1
1
females
(cont...)
1
SPECIAL SENSES SYSTEM
URINARY SYSTEM
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 89
1
+
+
1
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
0
5
0
7
3
3
0
6
8
1
0
5
6
3
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
1
0
6
0
3
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
1
0
6
8
4
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
6
4
6
0
0
5
2
6
0
0
5
2
7
0
0
5
2
8
0
0
5
2
9
0
0
5
3
0
0
0
5
3
1
0
0
5
3
2
0
0
5
3
3
0
0
5
3
4
0
0
5
3
5
0
0
5
3
6
0
0
5
3
7
0
0
5
3
8
0
0
5
3
9
0
0
5
4
0
0
0
5
4
1
0
0
5
4
2
0
0
5
4
3
0
0
5
4
4
0
0
5
4
5
0
0
5
4
6
0
0
5
4
7
0
0
5
4
8
0
0
5
4
9
0
0
5
5
0
* TOTALS
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Rectum
+
+
I
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
47
Intestine Small, Duodenum
Muscularis, Hypertrophy, Focal
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Small, Jejunum
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Fatty Change
Hepatodiaphragmatic Nodule
Necrosis
Bile Duct, Cyst, Multiple
Bile Duct, Dilatation
Bile Duct, Hyperplasia
+
+
+
+
+
X
X
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
ALIMENTARY SYSTEM
Mesentery
1 2.0
1 2.0
+
+
X
+
+
+
+
+
+
X
X
X
X
X
X
X
+
+
+
+
X
X
X
X
+
+
2
X
X
+
X
+
+
+
+
+
X
X
X
X
X
50
5
35
17
1
2
1
1
1
2
3
2
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 90
8
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
1.8
1.5
1.0
4.0
2.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
0
5
0
7
3
3
0
6
8
1
0
5
6
3
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
1
0
6
0
3
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
1
0
6
8
4
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
6
4
6
0
0
5
2
6
0
0
5
2
7
0
0
5
2
8
0
0
5
2
9
0
0
5
3
0
0
0
5
3
1
0
0
5
3
2
0
0
5
3
3
0
0
5
3
4
0
0
5
3
5
0
0
5
3
6
0
0
5
3
7
0
0
5
3
8
0
0
5
3
9
0
0
5
4
0
0
0
5
4
1
0
0
5
4
2
0
0
5
4
3
0
0
5
4
4
0
0
5
4
5
0
0
5
4
6
0
0
5
4
7
0
0
5
4
8
0
0
5
4
9
0
0
5
5
0
Fat, Necrosis
2
+
+
+
+
* TOTALS
2
+
+
+
+
+
+
+
+
+
8 2.0
Pancreas
Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
50
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Stomach, Forestomach
Inflammation, Acute
Inflammation, Chronic Active
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Stomach, Glandular
Mineralization
+
2 1.5
2 2.5
1 3.0
1 3.0
3
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
50
1 2.0
CARDIOVASCULAR SYSTEM
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
+
+
+
+
1
+
+
+
+
+
1
+
1
+
+
+
+
1
+
1
+
2
+
+
+
2
+
1
+
1
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
3
2
2
3
2
2
2
1
2
2
2
2
2
3
2
2
2
2
2
2
2
2
2
2
3
2
2
3
2
2
+
+
+
+
+
+
+
+
+
+
16 1.1
ENDOCRINE SYSTEM
Adrenal Cortex
Angiectasis
Degeneration, Cystic
Hyperplasia
Hypertrophy
+
+
+
+
+
2
2
1
2
1
4
2
2
3
4
Adrenal Medulla
+
+
+
+
+
+
2
3
2
2
3
+
+
+
+
2
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 91
2
+
+
+
+
+
50
1
29
27
24
+
49
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
2.0
2.3
2.1
2.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
0
5
0
7
3
3
0
6
8
1
0
5
6
3
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
1
0
6
0
3
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
1
0
6
8
4
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
6
4
6
0
0
5
2
6
0
0
5
2
7
0
0
5
2
8
0
0
5
2
9
0
0
5
3
0
0
0
5
3
1
0
0
5
3
2
0
0
5
3
3
0
0
5
3
4
0
0
5
3
5
0
0
5
3
6
0
0
5
3
7
0
0
5
3
8
0
0
5
3
9
0
0
5
4
0
0
0
5
4
1
0
0
5
4
2
0
0
5
4
3
0
0
5
4
4
0
0
5
4
5
0
0
5
4
6
0
0
5
4
7
0
0
5
4
8
0
0
5
4
9
0
0
5
5
0
* TOTALS
Hyperplasia
1 2.0
Islets, Pancreatic
Hyperplasia
+
+
+
Parathyroid Gland
+
+
+
+
+
Pituitary Gland
Pars Distalis, Hyperplasia
+
2
+
+
+
+
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
2
+
1
+
4
+
+
2
+
+
+
+
2
+
+
+
+
+
M
+
M
+
+
M
+
+
+
+
+
M
+
M
+
+
40
+
+
+
+
+
+
+
2
+
3
+
+
2
+
+
+
2
+
3
+
+
+
+
+
+
50
+
1
+
2
+
3
+
1
+
2
+
1
+
+
2
+
2
+
4
+
4
+
+
+
+
+
+
+
4
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1 2.0
+
+
2
+
2
+
2
+
2
10 2.4
+
50
43 2.3
1 1.0
1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland
Inflammation, Chronic
Inflammation, Chronic Active
+
Ovary
Cyst
+
Uterus
Adenomyosis
Cervix, Cyst, Squamous
Cervix, Hypertrophy
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
50
1 3.0
1 3.0
3
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
50
5 2.2
+
+
+
+
+
50
1 3.0
1 3.0
1 2.0
3
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 92
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
0
5
0
7
3
3
0
6
8
1
0
5
6
3
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
1
0
6
0
3
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
1
0
6
8
4
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
6
4
6
0
0
5
2
6
0
0
5
2
7
0
0
5
2
8
0
0
5
2
9
0
0
5
3
0
0
0
5
3
1
0
0
5
3
2
0
0
5
3
3
0
0
5
3
4
0
0
5
3
5
0
0
5
3
6
0
0
5
3
7
0
0
5
3
8
0
0
5
3
9
0
0
5
4
0
0
0
5
4
1
0
0
5
4
2
0
0
5
4
3
0
0
5
4
4
0
0
5
4
5
0
0
5
4
6
0
0
5
4
7
0
0
5
4
8
0
0
5
4
9
0
0
5
5
0
1
2
3
2
+
+
+
+
Endometrium, Hyperplasia, Cystic
3
3
* TOTALS
9 2.3
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
Lymph Node
Lumbar, Hyperplasia, Lymphoid
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
Lymph Node, Bronchial
Hyperplasia, Lymphohistiocytic
+
1
+
M
+
Lymph Node, Mandibular
+
+
+
M
Lymph Node, Mediastinal
Hemorrhage
Hyperplasia, Lymphohistiocytic
+
M
+
+
Lymph Node, Mesenteric
+
+
+
+
Spleen
Hematopoietic Cell Proliferation
+
+
+
+
Thymus
Cyst
+
+
+
+
1
1 1.0
+
1
M
+
+
+
+
+
+
+
+
M
I
M
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
M
+
2
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
50
+
4
+
+
+
45
+
3
+
1
+
50
+
+
+
M
+
M
+
M
M
M
+
+
+
M
+
1
M
+
M
+
32
+
+
M
+
+
+
43
+
+
M
+
+
+
45
7 1.1
1 2.0
4 1.3
+
M
+
+
+
+
M
+
+
+
+
+
+
M
+
+
3 2.7
1 4.0
INTEGUMENTARY SYSTEM
Mammary Gland
Galactocele
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 93
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
2 3.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
Skin
Inflammation, Chronic Active
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
0
5
0
7
3
3
0
6
8
1
0
5
6
3
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
1
0
6
0
3
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
1
0
6
8
4
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
6
4
6
0
0
5
2
6
0
0
5
2
7
0
0
5
2
8
0
0
5
2
9
0
0
5
3
0
0
0
5
3
1
0
0
5
3
2
0
0
5
3
3
0
0
5
3
4
0
0
5
3
5
0
0
5
3
6
0
0
5
3
7
0
0
5
3
8
0
0
5
3
9
0
0
5
4
0
0
0
5
4
1
0
0
5
4
2
0
0
5
4
3
0
0
5
4
4
0
0
5
4
5
0
0
5
4
6
0
0
5
4
7
0
0
5
4
8
0
0
5
4
9
0
0
5
5
0
* TOTALS
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
+
+
+
+
+
+
+
50
5 3.6
MUSCULOSKELETAL SYSTEM
Bone
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
NERVOUS SYSTEM
Brain
Peripheral Nerve
+
+
5
Spinal Cord
+
+
5
RESPIRATORY SYSTEM
Larynx
Metaplasia, Squamous
+
3
+
2
+
3
+
3
+
3
+
3
+
3
+
3
+
3
+
2
+
3
+
2
+
2
+
3
+
2
+
2
+
2
+
3
+
3
+
2
+
3
+
2
+
3
+
2
+
2
50
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
+
1
+
1
+
1
+
+
1
+
1
+
1
+
+
1
+
1
+
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
1
+
+
1
50
Nose
Inflammation, Chronic Active
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
2
2
1
4
2
1
2
2
3
2
1
3
2
1
3
2
2
3
2
2
1
4
3
1
3
2
1
3
2
1
2
2
1
4
3
1
3
3
1
4
1
2
1
2
3
1
3
3
3
1
1
2
3
4
1
2
2
3
3
2
1
3
3
4
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 94
2
50 2.5
42 1.0
1 3.0
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
1
48
34
50
1.0
2.0
1.1
2.9
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
30 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
0
7
3
2
0
7
3
2
0
7
3
3
0
7
3
1
0
7
0
5
0
7
3
3
0
6
8
1
0
5
6
3
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
1
0
6
0
3
0
7
3
2
0
7
3
3
0
7
3
2
0
7
3
1
0
6
8
4
0
7
3
2
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
2
0
7
3
2
0
6
4
6
0
0
5
2
6
0
0
5
2
7
0
0
5
2
8
0
0
5
2
9
0
0
5
3
0
0
0
5
3
1
0
0
5
3
2
0
0
5
3
3
0
0
5
3
4
0
0
5
3
5
0
0
5
3
6
0
0
5
3
7
0
0
5
3
8
0
0
5
3
9
0
0
5
4
0
0
0
5
4
1
0
0
5
4
2
0
0
5
4
3
0
0
5
4
4
0
0
5
4
5
0
0
5
4
6
0
0
5
4
7
0
0
5
4
8
0
0
5
4
9
0
0
5
5
0
3
1
1
1
1
1
1
1
1
1
1
2
1
1
1
Respiratory Epithelium, Accumulation, Hyaline
Droplet
Trachea
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
1
* TOTALS
31 1.1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Eye
Cataract
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Harderian Gland
Hyperplasia
+
SPECIAL SENSES SYSTEM
2
+
2
+
+
1
+
+
+
+
+
1
1
1
+
2
+
+
+
+
+
3
+
+
+
+
+
1 4.0
4 2.3
2
+
+
+
+
1
+
+
+
+
+
+
+
50
5 1.4
URINARY SYSTEM
Kidney
Cyst
Nephropathy
Transitional Epithelium, Hyperplasia
+
Urinary Bladder
+
1
+
+
+
+
+
+
+
+
+
1
+
+
1
+
+
1
+
1
+
+
+
1
+
2
1
50
+
50
2 2.0
19 1.2
1 1.0
1
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 95
+
+
+
+
+
+
+
+
+
+
+
+
+
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
5
0
7
3
1
0
7
0
3
0
6
3
3
0
7
3
2
0
7
3
2
0
6
6
3
0
5
2
3
0
7
1
7
0
7
0
3
0
7
3
3
0
7
3
1
0
6
3
5
0
7
3
1
0
7
3
2
0
6
9
1
0
7
3
2
0
7
3
3
0
7
2
5
0
7
3
3
0
6
3
0
0
7
3
1
0
5
8
6
0
6
7
0
0
6
3
9
0
0
7
0
1
0
0
7
0
2
0
0
7
0
3
0
0
7
0
4
0
0
7
0
5
0
0
7
0
6
0
0
7
0
7
0
0
7
0
8
0
0
7
0
9
0
0
7
1
0
0
0
7
1
1
0
0
7
1
2
0
0
7
1
3
0
0
7
1
4
0
0
7
1
5
0
0
7
1
6
0
0
7
1
7
0
0
7
1
8
0
0
7
1
9
0
0
7
2
0
0
0
7
2
1
0
0
7
2
2
0
0
7
2
3
0
0
7
2
4
0
0
7
2
5
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
Intestine Large, Rectum
+
I
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
I
A
+
+
+
+
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
A
+
+
+
+
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Degeneration, Cystic
Eosinophilic Focus
Fatty Change
Bile Duct, Cyst
Bile Duct, Cyst, Multiple
Bile Duct, Dilatation
Bile Duct, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
+
2
X
X
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
females
(cont...)
ALIMENTARY SYSTEM
Mesentery
Inflammation, Chronic Active
X
X
X
4
1
X
2
1
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 96
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
5
0
7
3
1
0
7
0
3
0
6
3
3
0
7
3
2
0
7
3
2
0
6
6
3
0
5
2
3
0
7
1
7
0
7
0
3
0
7
3
3
0
7
3
1
0
6
3
5
0
7
3
1
0
7
3
2
0
6
9
1
0
7
3
2
0
7
3
3
0
7
2
5
0
7
3
3
0
6
3
0
0
7
3
1
0
5
8
6
0
6
7
0
0
6
3
9
0
0
7
0
1
0
0
7
0
2
0
0
7
0
3
0
0
7
0
4
0
0
7
0
5
0
0
7
0
6
0
0
7
0
7
0
0
7
0
8
0
0
7
0
9
0
0
7
1
0
0
0
7
1
1
0
0
7
1
2
0
0
7
1
3
0
0
7
1
4
0
0
7
1
5
0
0
7
1
6
0
0
7
1
7
0
0
7
1
8
0
0
7
1
9
0
0
7
2
0
0
0
7
2
1
0
0
7
2
2
0
0
7
2
3
0
0
7
2
4
0
0
7
2
5
Fat, Necrosis
females
(cont...)
2
Oral Mucosa
Developmental Malformation
Inflammation, Chronic Active
+
X
4
Pancreas
Atrophy
+
+
+
+
+
1
+
+
+
1
+
+
+
1
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Ulcer
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
Stomach, Glandular
Inflammation, Chronic Active
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Heart
Cardiomyopathy
Mineralization
+
1
+
+
+
+
+
+
2
2
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
1
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
+
+
+
+
3
2
2
1
2
2
3
2
1
2
2
2
2
2
2
3
1
2
2
CARDIOVASCULAR SYSTEM
ENDOCRINE SYSTEM
Adrenal Cortex
Angiectasis
Degeneration, Cystic
Hyperplasia
1
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 97
2
2
2
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
5
0
7
3
1
0
7
0
3
0
6
3
3
0
7
3
2
0
7
3
2
0
6
6
3
0
5
2
3
0
7
1
7
0
7
0
3
0
7
3
3
0
7
3
1
0
6
3
5
0
7
3
1
0
7
3
2
0
6
9
1
0
7
3
2
0
7
3
3
0
7
2
5
0
7
3
3
0
6
3
0
0
7
3
1
0
5
8
6
0
6
7
0
0
6
3
9
0
0
7
0
1
0
0
7
0
2
0
0
7
0
3
0
0
7
0
4
0
0
7
0
5
0
0
7
0
6
0
0
7
0
7
0
0
7
0
8
0
0
7
0
9
0
0
7
1
0
0
0
7
1
1
0
0
7
1
2
0
0
7
1
3
0
0
7
1
4
0
0
7
1
5
0
0
7
1
6
0
0
7
1
7
0
0
7
1
8
0
0
7
1
9
0
0
7
2
0
0
0
7
2
1
0
0
7
2
2
0
0
7
2
3
0
0
7
2
4
0
0
7
2
5
2
2
2
3
2
2
Hypertrophy
2
2
2
Adrenal Medulla
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Islets, Pancreatic
Hyperplasia
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Parathyroid Gland
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
M
+
+
+
+
+
+
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
2
+
2
+
+
+
+
+
+
+
+
+
+
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
2
+
1
+
2
+
+
1
+
1
+
+
1
+
1
+
2
+
1
+
1
+
1
+
+
1
+
+
1
+
2
+
1
+
1
A
+
2
+
1
+
+
Clitoral Gland
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
Ovary
Cyst
Interstitial Cell, Hyperplasia
+
+
+
+
3
+
+
+
+
+
1
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
3
Uterus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
females
(cont...)
2
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 98
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
5
0
7
3
1
0
7
0
3
0
6
3
3
0
7
3
2
0
7
3
2
0
6
6
3
0
5
2
3
0
7
1
7
0
7
0
3
0
7
3
3
0
7
3
1
0
6
3
5
0
7
3
1
0
7
3
2
0
6
9
1
0
7
3
2
0
7
3
3
0
7
2
5
0
7
3
3
0
6
3
0
0
7
3
1
0
5
8
6
0
6
7
0
0
6
3
9
0
0
7
0
1
0
0
7
0
2
0
0
7
0
3
0
0
7
0
4
0
0
7
0
5
0
0
7
0
6
0
0
7
0
7
0
0
7
0
8
0
0
7
0
9
0
0
7
1
0
0
0
7
1
1
0
0
7
1
2
0
0
7
1
3
0
0
7
1
4
0
0
7
1
5
0
0
7
1
6
0
0
7
1
7
0
0
7
1
8
0
0
7
1
9
0
0
7
2
0
0
0
7
2
1
0
0
7
2
2
0
0
7
2
3
0
0
7
2
4
0
0
7
2
5
4
1
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Bronchial
Hyperplasia, Lymphohistiocytic
M
+
1
M
M
+
2
M
M
+
1
+
2
+
1
+
3
+
1
+
1
M
M
M
+
1
+
1
+
4
+
1
+
3
M
+
1
+
+
1
Lymph Node, Mandibular
Ectasia
+
+
+
+
+
+
+
+
+
+
2
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
Lymph Node, Mediastinal
Hyperplasia, Lymphohistiocytic
Hyperplasia, Lymphoid
+
+
1
+
1
+
+
+
+
+
+
2
+
M
+
+
1
+
2
+
+
+
2
+
2
+
+
+
+
+
M
+
Lymph Node, Mesenteric
Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Spleen
Hematopoietic Cell Proliferation
+
4
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Thymus
+
+
+
+
+
+
+
+
+
+
+
M
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
+
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
Cervix, Hypertrophy
Endometrium, Hyperplasia, Cystic
females
(cont...)
3
Vagina
HEMATOPOIETIC SYSTEM
3
INTEGUMENTARY SYSTEM
Mammary Gland
Galactocele
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 99
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
0
7
1
5
0
7
3
1
0
7
0
3
0
6
3
3
0
7
3
2
0
7
3
2
0
6
6
3
0
5
2
3
0
7
1
7
0
7
0
3
0
7
3
3
0
7
3
1
0
6
3
5
0
7
3
1
0
7
3
2
0
6
9
1
0
7
3
2
0
7
3
3
0
7
2
5
0
7
3
3
0
6
3
0
0
7
3
1
0
5
8
6
0
6
7
0
0
6
3
9
0
0
7
0
1
0
0
7
0
2
0
0
7
0
3
0
0
7
0
4
0
0
7
0
5
0
0
7
0
6
0
0
7
0
7
0
0
7
0
8
0
0
7
0
9
0
0
7
1
0
0
0
7
1
1
0
0
7
1
2
0
0
7
1
3
0
0
7
1
4
0
0
7
1
5
0
0
7
1
6
0
0
7
1
7
0
0
7
1
8
0
0
7
1
9
0
0
7
2
0
0
0
7
2
1
0
0
7
2
2
0
0
7
2
3
0
0
7
2
4
0
0
7
2
5
Hyperplasia
Inflammation, Chronic Active
Skin
Inflammation, Chronic Active
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
females
(cont...)
2
+
+
4
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Peripheral Nerve
+
+
+
+
Spinal Cord
+
+
+
+
MUSCULOSKELETAL SYSTEM
Bone
NERVOUS SYSTEM
Brain
Meninges, Hyperplasia
RESPIRATORY SYSTEM
Larynx
Foreign Body
Inflammation, Acute
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
+
2
+
2
+
2
+
1
+
2
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
2
1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 100
1
1
+
X
1
3
+
+
+
+
+
+
3
3
3
1
3
1
3
3
+
2
4
+
2
+
2
+
2
+
2
1
+
2
+
2
1
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
5
0
7
3
1
0
7
0
3
0
6
3
3
0
7
3
2
0
7
3
2
0
6
6
3
0
5
2
3
0
7
1
7
0
7
0
3
0
7
3
3
0
7
3
1
0
6
3
5
0
7
3
1
0
7
3
2
0
6
9
1
0
7
3
2
0
7
3
3
0
7
2
5
0
7
3
3
0
6
3
0
0
7
3
1
0
5
8
6
0
6
7
0
0
6
3
9
0
0
7
0
1
0
0
7
0
2
0
0
7
0
3
0
0
7
0
4
0
0
7
0
5
0
0
7
0
6
0
0
7
0
7
0
0
7
0
8
0
0
7
0
9
0
0
7
1
0
0
0
7
1
1
0
0
7
1
2
0
0
7
1
3
0
0
7
1
4
0
0
7
1
5
0
0
7
1
6
0
0
7
1
7
0
0
7
1
8
0
0
7
1
9
0
0
7
2
0
0
0
7
2
1
0
0
7
2
2
0
0
7
2
3
0
0
7
2
4
0
0
7
2
5
Nose
Inflammation, Acute
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
1
4
2
1
4
2
3
1
4
3
1
4
2
1
4
3
2
4
3
2
1
2
3
1
3
3
2
4
3
3
1
4
2
1
3
3
1
3
3
1
4
2
2
3
3
1
2
3
2
3
3
1
4
2
1
3
2
1
3
3
1
4
3
2
4
1
1
1
1
3
1
1
1
1
1
1
1
1
1
2
Trachea
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Eye
Cornea, Inflammation, Chronic Active
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
+
+
+
+
+
+
Harderian Gland
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
1
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
4
1
4
4
3
females
(cont...)
SPECIAL SENSES SYSTEM
Zymbal's Gland
+
URINARY SYSTEM
Kidney
Hydronephrosis
Mineralization
Nephropathy
Renal Tubule, Hyperplasia
+
+
3
1
2
+
+
+
+
+
4
+
+
+
+
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 101
+
+
1
+
+
+
1
+
+
+
1
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
Urinary Bladder
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
1
5
0
7
3
1
0
7
0
3
0
6
3
3
0
7
3
2
0
7
3
2
0
6
6
3
0
5
2
3
0
7
1
7
0
7
0
3
0
7
3
3
0
7
3
1
0
6
3
5
0
7
3
1
0
7
3
2
0
6
9
1
0
7
3
2
0
7
3
3
0
7
2
5
0
7
3
3
0
6
3
0
0
7
3
1
0
5
8
6
0
6
7
0
0
6
3
9
0
0
7
0
1
0
0
7
0
2
0
0
7
0
3
0
0
7
0
4
0
0
7
0
5
0
0
7
0
6
0
0
7
0
7
0
0
7
0
8
0
0
7
0
9
0
0
7
1
0
0
0
7
1
1
0
0
7
1
2
0
0
7
1
3
0
0
7
1
4
0
0
7
1
5
0
0
7
1
6
0
0
7
1
7
0
0
7
1
8
0
0
7
1
9
0
0
7
2
0
0
0
7
2
1
0
0
7
2
2
0
0
7
2
3
0
0
7
2
4
0
0
7
2
5
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 102
females
(cont...)
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
3
0
7
3
0
0
7
2
5
0
6
8
1
0
6
7
3
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
2
0
7
3
3
0
7
3
3
0
6
4
5
0
7
3
1
0
7
1
9
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
1
0
7
3
1
0
7
3
2
0
7
2
2
0
0
7
2
6
0
0
7
2
7
0
0
7
2
8
0
0
7
2
9
0
0
7
3
0
0
0
7
3
1
0
0
7
3
2
0
0
7
3
3
0
0
7
3
4
0
0
7
3
5
0
0
7
3
6
0
0
7
3
7
0
0
7
3
8
0
0
7
3
9
0
0
7
4
0
0
0
7
4
1
0
0
7
4
2
0
0
7
4
3
0
0
7
4
4
0
0
7
4
5
0
0
7
4
6
0
0
7
4
7
0
0
7
4
8
0
0
7
4
9
0
0
7
5
0
* TOTALS
Esophagus
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Intestine Large, Cecum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Large, Colon
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Large, Rectum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
I
+
+
+
+
+
+
+
+
+
46
Intestine Small, Duodenum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Small, Ileum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Intestine Small, Jejunum
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Liver
Angiectasis
Basophilic Focus
Clear Cell Focus
Degeneration, Cystic
Eosinophilic Focus
Fatty Change
Bile Duct, Cyst
Bile Duct, Cyst, Multiple
Bile Duct, Dilatation
Bile Duct, Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
X
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
ALIMENTARY SYSTEM
Mesentery
Inflammation, Chronic Active
X
X
X
X
X
1
32
14
1
1
1
1
3
3
6
2
2
X
3
2
4
1
+
2
1
+
+
+
2.0
2.0
2.0
3.7
1.3
5
1 2.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 103
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
3
0
7
3
0
0
7
2
5
0
6
8
1
0
6
7
3
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
2
0
7
3
3
0
7
3
3
0
6
4
5
0
7
3
1
0
7
1
9
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
1
0
7
3
1
0
7
3
2
0
7
2
2
0
0
7
2
6
0
0
7
2
7
0
0
7
2
8
0
0
7
2
9
0
0
7
3
0
0
0
7
3
1
0
0
7
3
2
0
0
7
3
3
0
0
7
3
4
0
0
7
3
5
0
0
7
3
6
0
0
7
3
7
0
0
7
3
8
0
0
7
3
9
0
0
7
4
0
0
0
7
4
1
0
0
7
4
2
0
0
7
4
3
0
0
7
4
4
0
0
7
4
5
0
0
7
4
6
0
0
7
4
7
0
0
7
4
8
0
0
7
4
9
0
0
7
5
0
Fat, Necrosis
2
2
* TOTALS
2
4 2.0
Oral Mucosa
Developmental Malformation
Inflammation, Chronic Active
1
1
1 4.0
Pancreas
Atrophy
+
+
Salivary Glands
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Forestomach
Ulcer
+
+
+
+
+
+
3
+
+
+
+
+
+
+
+
+
+
+
+
+
+
Stomach, Glandular
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
+
+
50
+
+
+
+
+
50
+
+
+
+
+
50
5 1.6
2 3.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1 2.0
CARDIOVASCULAR SYSTEM
Blood Vessel
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Heart
Cardiomyopathy
Mineralization
+
+
+
1
+
2
+
1
+
+
1
+
1
+
+
+
+
+
+
1
+
1
+
+
+
+
+
1
+
+
+
+
1
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
4
2
2
2
3
2
2
1
2
2
2
2
1
2
2
2
2
4
1
2
2
2
14 1.1
1 2.0
ENDOCRINE SYSTEM
Adrenal Cortex
Angiectasis
Degeneration, Cystic
Hyperplasia
+
+
3
2
2
2
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 104
+
2
2
+
+
+
+
3
2
3
2
3
2
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
2 2.0
35 2.1
22 2.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
3
0
7
3
0
0
7
2
5
0
6
8
1
0
6
7
3
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
2
0
7
3
3
0
7
3
3
0
6
4
5
0
7
3
1
0
7
1
9
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
1
0
7
3
1
0
7
3
2
0
7
2
2
0
0
7
2
6
0
0
7
2
7
0
0
7
2
8
0
0
7
2
9
0
0
7
3
0
0
0
7
3
1
0
0
7
3
2
0
0
7
3
3
0
0
7
3
4
0
0
7
3
5
0
0
7
3
6
0
0
7
3
7
0
0
7
3
8
0
0
7
3
9
0
0
7
4
0
0
0
7
4
1
0
0
7
4
2
0
0
7
4
3
0
0
7
4
4
0
0
7
4
5
0
0
7
4
6
0
0
7
4
7
0
0
7
4
8
0
0
7
4
9
0
0
7
5
0
2
2
2
2
2
2
2
2
2
Hypertrophy
2
3
* TOTALS
2
21 2.1
Adrenal Medulla
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
49
Islets, Pancreatic
Hyperplasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Parathyroid Gland
+
+
+
+
M
+
M
+
+
M
+
+
+
M
+
+
+
+
+
+
+
+
I
+
+
42
Pituitary Gland
Pars Distalis, Hyperplasia
Pars Intermedia, Hyperplasia
+
+
3
+
+
+
3
+
+
2
+
+
+
+
+
+
+
+
2
+
+
2
+
2
+
+
+
+
+
+
+
50
Thyroid Gland
C-cell, Hyperplasia
Follicular Cell, Hyperplasia
+
1
+
3
+
1
+
1
+
+
+
2
+
1
+
1
+
+
+
1
+
Clitoral Gland
Inflammation, Chronic Active
+
+
+
+
+
+
+
+
+
+
+
Ovary
Cyst
Interstitial Cell, Hyperplasia
+
Uterus
+
1 3.0
+
+
2
+
1
+
2
+
2
+
+
+
+
+
+
9 2.1
1 2.0
+
1
+
+
+
+
3
+
2
+
4
2
+
2
49
+
+
+
+
49
35 1.5
1 2.0
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
+
+
+
1 4.0
+
+
+
2
+
2
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
2
+
+
+
+
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 105
+
+
+
+
+
+
+
3
+
+
+
+
+
+
2
+
+
+
+
+
+
+
+
2
+
+
+
50
11 2.1
1 3.0
50
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
3
0
7
3
0
0
7
2
5
0
6
8
1
0
6
7
3
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
2
0
7
3
3
0
7
3
3
0
6
4
5
0
7
3
1
0
7
1
9
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
1
0
7
3
1
0
7
3
2
0
7
2
2
0
0
7
2
6
0
0
7
2
7
0
0
7
2
8
0
0
7
2
9
0
0
7
3
0
0
0
7
3
1
0
0
7
3
2
0
0
7
3
3
0
0
7
3
4
0
0
7
3
5
0
0
7
3
6
0
0
7
3
7
0
0
7
3
8
0
0
7
3
9
0
0
7
4
0
0
0
7
4
1
0
0
7
4
2
0
0
7
4
3
0
0
7
4
4
0
0
7
4
5
0
0
7
4
6
0
0
7
4
7
0
0
7
4
8
0
0
7
4
9
0
0
7
5
0
Cervix, Hypertrophy
Endometrium, Hyperplasia, Cystic
* TOTALS
2
1
1 2.0
5 2.4
3
Vagina
+
1
HEMATOPOIETIC SYSTEM
Bone Marrow
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Lymph Node, Bronchial
Hyperplasia, Lymphohistiocytic
+
1
+
+
2
+
2
M
+
2
+
1
+
M
+
+
1
+
M
+
2
M
+
3
M
+
2
+
1
M
+
2
+
1
+
2
+
1
+
2
35
Lymph Node, Mandibular
Ectasia
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
M
+
+
49
Lymph Node, Mediastinal
Hyperplasia, Lymphohistiocytic
Hyperplasia, Lymphoid
+
2
+
Lymph Node, Mesenteric
Ectasia
+
+
Spleen
Hematopoietic Cell Proliferation
+
Thymus
+
+
+
+
+
+
+
+
+
+
+
+
M
+
I
+
+
I
+
M
+
+
+
+
+
45
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
30 1.6
2 2.5
+
+
1
+
3
+
2
+
1
+
1
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
2
+
3
+
+
2
+
+
+
+
+
2
+
+
+
+
+
+
1
+
1
I
+
+
+
+
2
+
+
+
+
+
+
2
+
1
+
+
+
+
+
2
47
+
50
23 1.7
1 3.0
1 2.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
1 4.0
INTEGUMENTARY SYSTEM
Mammary Gland
Galactocele
1 4.0
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 106
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
3
0
7
3
0
0
7
2
5
0
6
8
1
0
6
7
3
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
2
0
7
3
3
0
7
3
3
0
6
4
5
0
7
3
1
0
7
1
9
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
1
0
7
3
1
0
7
3
2
0
7
2
2
0
0
7
2
6
0
0
7
2
7
0
0
7
2
8
0
0
7
2
9
0
0
7
3
0
0
0
7
3
1
0
0
7
3
2
0
0
7
3
3
0
0
7
3
4
0
0
7
3
5
0
0
7
3
6
0
0
7
3
7
0
0
7
3
8
0
0
7
3
9
0
0
7
4
0
0
0
7
4
1
0
0
7
4
2
0
0
7
4
3
0
0
7
4
4
0
0
7
4
5
0
0
7
4
6
0
0
7
4
7
0
0
7
4
8
0
0
7
4
9
0
0
7
5
0
Hyperplasia
Inflammation, Chronic Active
Skin
Inflammation, Chronic Active
2
+
+
+
2
+
+
+
+
+
+
+
+
+
+
+
3
+
+
+
+
* TOTALS
1 2.0
2 2.0
2
+
+
+
+
+
+
+
50
4 2.8
MUSCULOSKELETAL SYSTEM
Bone
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
+
+
50
NERVOUS SYSTEM
Brain
Meninges, Hyperplasia
1 1.0
Peripheral Nerve
+
+
6
Spinal Cord
+
+
6
RESPIRATORY SYSTEM
Larynx
Foreign Body
Inflammation, Acute
Metaplasia, Squamous
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
3
3
3
3
3
2
3
3
3
3
3
3
3
2
2
3
Lung
Inflammation, Lymphohistiocytic
Alveolar Epithelium, Hyperplasia
Bronchus-associated Lymphoid Tissue,
Hyperplasia, Lymphohistiocytic
+
2
+
2
+
2
+
2
+
2
+
2
+
2
1
+
2
+
2
+
2
+
2
+
2
+
2
+
2
+
1
+
2
+
+
+
+
+
+
+
+
+
2
1
1
3
3
3
2
3
3
3
+
2
4
+
2
+
1
+
2
+
2
+
1
+
2
1
+
2
+
2
2
50
1
4 1.0
50 2.8
50
1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 107
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
50 1.9
7 2.1
5 1.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
3
0
7
3
0
0
7
2
5
0
6
8
1
0
6
7
3
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
2
0
7
3
3
0
7
3
3
0
6
4
5
0
7
3
1
0
7
1
9
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
1
0
7
3
1
0
7
3
2
0
7
2
2
0
0
7
2
6
0
0
7
2
7
0
0
7
2
8
0
0
7
2
9
0
0
7
3
0
0
0
7
3
1
0
0
7
3
2
0
0
7
3
3
0
0
7
3
4
0
0
7
3
5
0
0
7
3
6
0
0
7
3
7
0
0
7
3
8
0
0
7
3
9
0
0
7
4
0
0
0
7
4
1
0
0
7
4
2
0
0
7
4
3
0
0
7
4
4
0
0
7
4
5
0
0
7
4
6
0
0
7
4
7
0
0
7
4
8
0
0
7
4
9
0
0
7
5
0
* TOTALS
Nose
Inflammation, Acute
Glands, Olfactory Epithelium, Hyperplasia
Goblet Cell, Hyperplasia
Olfactory Epithelium, Accumulation, Hyaline
Droplet
Respiratory Epithelium, Accumulation, Hyaline
Droplet
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
3
3
1
4
3
1
4
2
1
1
4
2
1
4
3
2
4
3
2
4
3
1
3
3
1
3
3
1
3
2
1
3
2
1
4
3
2
3
2
1
4
+
1
2
1
3
3
3
1
3
3
1
3
2
1
3
3
3
1
3
3
1
4
3
1
4
1
1
4
1
49
42
50
1
2
1
1
2
2
1
1
1
1
1
1
1
1
1
1
1
34 1.2
Trachea
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Eye
Cornea, Inflammation, Chronic Active
Retina, Atrophy
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
Harderian Gland
Hyperplasia
+
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
3
4
3
1
3
1.0
2.6
1.2
3.5
SPECIAL SENSES SYSTEM
3
+
+
+
2
+
+
1
+
1 4.0
2 2.5
2
+
1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
1
+
+
50
4 1.3
Zymbal's Gland
1
URINARY SYSTEM
Kidney
Hydronephrosis
Mineralization
Nephropathy
Renal Tubule, Hyperplasia
+
1
+
+
1
+
+
2
+
+
+
+
+
1
+
1
+
+
+
+
1
+
+
+
+
+
2
1
+
+
+
1
+
+
50
1
1
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 108
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked
1
1
18
1
3.0
2.0
1.3
1.0
Experiment Number: 20515 - 03
Test Type: CHRONIC
P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
Metal working fluids (CIMSTAR 3800)
Route: RESPIRATORY EXPOSURE WHOLE BODY
Species/Strain: RATS/Wistar Han
DAY ON TEST
WISTAR HAN RATS FEMALE
100 mg/m3
ANIMAL ID
Urinary Bladder
Date Report Requested: 05/08/2013
Time Report Requested: 08:51:01
CAS Number: CIMSTAR3800
First Dose M/F: 04/14/08 / 04/14/08
Lab: BNW
0
7
3
2
0
7
3
3
0
7
3
0
0
7
2
5
0
6
8
1
0
6
7
3
0
7
3
1
0
7
3
2
0
7
3
3
0
7
3
3
0
7
3
2
0
7
3
3
0
7
3
3
0
6
4
5
0
7
3
1
0
7
1
9
0
7
3
1
0
7
3
1
0
7
3
2
0
7
3
1
0
7
3
3
0
7
3
1
0
7
3
1
0
7
3
2
0
7
2
2
0
0
7
2
6
0
0
7
2
7
0
0
7
2
8
0
0
7
2
9
0
0
7
3
0
0
0
7
3
1
0
0
7
3
2
0
0
7
3
3
0
0
7
3
4
0
0
7
3
5
0
0
7
3
6
0
0
7
3
7
0
0
7
3
8
0
0
7
3
9
0
0
7
4
0
0
0
7
4
1
0
0
7
4
2
0
0
7
4
3
0
0
7
4
4
0
0
7
4
5
0
0
7
4
6
0
0
7
4
7
0
0
7
4
8
0
0
7
4
9
0
0
7
5
0
* TOTALS
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
50
*** END OF REPORT ***
* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade
+ .. Tissue examined microscopically
M .. Missing tissue
X .. Lesion present
A .. Autolysis precludes evaluation
I .. Insufficient tissue
BLANK .. Not examined microscopically
Page 109
1-4 .. Lesion qualified as:
1) Minimal 3) Moderate
2) Mild
4) Marked