Acknowledgements

Acknowledgements
Det har varit en rolig tid, om än rätt intensiv på slutet, och det är många jag har att
tacka för att denna avhandling har blivit till!
Tack Malin Brändén Åkerblom som väckte mitt intresse för kemi och som handledde
mitt examensarbete: ”Gaskromatografisk restbestämning av ogräsmedlet
bromofenoxim” långt före (som det känns) datorernas tid (det fanns dock telefon).
Tack mina handledare Göran Odham och Michael McLachlan. Ett speciellt tack till
Michael för ditt starka stöd på sluttampen.
Tack till Zoofysiologerna i Göteborg för det inspirerande tvärvetenskapliga
samarbetet. Tack Lars Förlin för att du alltid ställer upp och tar dig tid med mina
frågor, Jari Parkkonen för att du räddade fiskarna undan kvävningsdöden, Joachim
Sturve för att du aldrig är främmande för nya projekt, Eirikur Stephensen likaså för
värdefullt samarbete.
Tack Joakim Larsson för ditt stöd, alla spännande projekt och din okuvliga energi.
Tack Erik Lindesjöö som till slut rodde det otursförföljda försöket i hamn. Tack alla
övriga medförfattare.
Tack Lillemor, min biträdande handledare för att du alltid ställer upp som stöd och
bollplank och dessutom fixar hemtransport efter festerna.
Tack min mångåriga labkompis Maria för allt vårt samarbete, dina kreativa alster och
att du älskar att dansa lika mycket som jag.
Tack för stöd och hjälp med allehanda ting till övriga kära arbetskamrater på Mo.
Tack Uffe för ditt stöd och din kreativa händighet. Tack Carina, Malin, Ulrika, Mats
och Kattis. Tack Tomas som tålmodigt ställer upp med kloka råd, Micke som
förgäves försökt lära mig datorernas hemligheter, Ulla E, Kerstin, Ulla S, Anna-Lena,
Cindy, Bosse, Lotta, Ann-Sofie, Lisbeth och Anna-Karin. Tack alla övriga ITM:are
och miljökemister för trevlig samvaro och fruktbart samarbete. Tack Cajsa för allt
trevligt samarbete genom åren.
Ett speciellt tack till Amelie, som aldrig ger upp, för all hjälp och stöd, för alla
intressanta och givande vetenskapliga diskussioner för att inte tala om alla andra
kreativa stunder och dina fantastiska kreativa skapelser. Vi kommer garanterat att bli
rätt gamla, du och jag.
Slutligen ett tack till min stora underbara familj som sett till att jag inte bara ägnat mig
åt gallanalyser. Jag önskar bara att pappa hade levat!
20
References
Aas,E., Baussant,T., Balk,L., Liewenborg,B. and Andersen,O.K. (2000). PAH metabolites in bile,
cytochrome P4501A and DNA adducts as environmental risk parameters for chronic oil exposure: a
laboratory experiment with Atlantic cod. Aquat. Toxicol. 51, pp. 241-258.
Adolfsson-Erici,M., Johansson,C. and Pettersson,M. (2003). Screening av triclosan i reningsverk och
recipienter. ITM-rapport in Swedish 116, pp. 1-18.
Adolfsson-Erici,M., Pettersson,M., Parkkonen,J. and Sturve,J. (2000). Triclosan, a commonly used
bactericide found in human milk and in the aquatic environment in Sweden. Organohalogen
Compounds 45, pp. 83-86.
Ahlbom,J. and Duus,U. (1994). Nya hjulspår - en produktstudie av gummidäck. Rapport från
kemikalieinspektionen 6/94, pp. 1-82.
Allard,A.-S., Gunnarsson,M. and Svenson,A. (2004). Estrogenicity in bile of juvenile rainbow trout as
measure of exposure and potential effects of endocrine disruptors. Environ. Toxicol. Chem. 23(5),
pp. 1187-1193.
Ariese,F., Beyer,J, Wells,D., Maier, E.A., Gawlik,B.M. and Lanberty, A. (2004). The certification of
the mass fraction of PAH metabolites (1-hydroxyphenanthrene, 1-hydroxypyrene and 3hydroxy(a)pyrene) in two fish bile materials. Report EUR 21068, 1-49.
Ariese,F., Kok,S.J., Verkaik,M., Gooijer,C., Velthorst,N.H. and Hofstraat,J.W. (1993). Synchronous
fluorescence spectrometry of fish bile: A rapid screening method for the biomonitoring of PAH
exposure. Aquat. Toxicol. 26, pp. 273-286.
Barra,R., Sanchez-Hernandez,J.C., Orrego,R., Parra,O. and Gavilan,J.F. (2001). Bioavailability of
PAHs in the Biobio river (Chile): MFO activity and bilary fluorescence in juvenile Oncorhynchus
mykiss. Chemophere 45, pp. 439-444.
Belfroid,A.C., Van Der Horst,A., Vethaak,A.D., Schäfer,A.J., Rijs,G.B.J., Wegener,J. and Cofino,W.P.
(1999). Analysis and occurence of estrogenic hormones and their glucuronides in surface water in
the Netherlands. Sci. Tot. Environ. 225, pp. 101-108.
Bester,K. (2003). Triclosan in a sewage treatment process-balances and monitoring data. Water Res.
37, pp. 3891-3896.
Birkel,M., Erking,W. and Wetzelsberger,N. (1993). Improved internally standardized GC-ECD method
for the determination of free and conjugated triclosan (Irgasan DP300) in human plasma. Meth.
Find. Exp. Clin. Pharmacol. 15(9), pp. 623-627.
Bortone,S.A., Davis,W.P. and Bundrick,C.M. (1989). Morphological and behavioral characters in
mosquitofish as potential bioindication of exposure to kraft mill effluent. Bulletin of environmental
contamination and toxicology 43(3), pp. 370-377.
Brown,J.S. and Steinert,S.A. (2003). DNA damage and bilary PAH metabolites in flatfish from
southern California bays and harbors, and the Channel Islands. Ecol. Ind. 3, pp. 263-274.
Brumley,C.M., Harritos,V.S., Ahokas,J.T. and Holdway,D.A. (1998). The effects of exposure duration
and feeding status on fish bile metabolites: Implications for biomonitoring. Ecotoxic. Environ. Saf.
39, pp. 147-153.
Chau,A.S.Y. and Coburn,J.A. (1974). Determination of pentachlorophenol in natural and wastewaters.
J. A.O.A.C. 57(2), pp. 389-393.
21
Ciba-Geigy (1998). IRGASAN DP 300/IRGACARE MP: Toxicological and ecological data/Official
registration. Brochure no 2521 .
Clarke,D.J., George,S.G. and Burchell,B. (1991). Glucuronidation in fish. Aquat. Toxicol. 20, pp. 3556.
Cohen,A.M., Nugegoda,D. and Gagnon,M.M. (2001). The effect of different oil spill remediation
techniques on petrolium hydrocarbon elimination in Australian Bass (Marcuaria novemaculeata).
Arch. Environ. Contam. Toxicol. 40, pp. 264-270.
Collier,T.K. and Varanasi,U. (1991). Hepatic activities of xenobiotic metabolizing enzymes and biliary
levels of xenobiotics in English sole (Parophrys vetulus) exposed to environmental contaminants.
Archives of Environmental Contamination and Toxicology 20(4), pp. 462-473.
D'Ascenzo,G., Di Corcia,A., Gentili,A., Mancini,R., Mastropasqua,R., Nazzari,M. and Samperi,R.
(2003). Fate of natural estrogen conjugates in municipal sewage transport and treatment facilities.
Sci. Tot. Environ 302, pp. 199-209.
Day,K.E., Holtze,K.E., Metcalfe-Smith,J.L., Bishop,C.T. and Dutka,B.J. (1993). Toxicity of leachate
from automobile tires to aquatic biota. Chemophere 27 (4), pp. 665-675.
Denton,T.E., Howell,W.M., Allison,S., McCollum,J. and Marks,B. (1985). Masculinisation of female
mosquitofish by exposure to plant sterols and mycobacterium smegmatis. Bull. Environ. Contam.
Toxicol. 35, pp. 627-632.
Desbrow,C., Routledge,E.J., Brightly,G.C., Sumpter,J.P. and Waldock,M. (1998). Identification of
estrogenic chemicals in STW effluents. 1. Chemical fractionation and in vitro biological screening.
Environ. Sci. Technol. 32, pp. 1549-1558.
Drzyzga,O. (2003). Diphenylamine and derivatives in the environment: a review. Chemophere 53, pp.
809-818.
Ellis,R.J., van den Heuvel,M.R., Bandelj,E., Smith,M.A., McCarthy,L.H., Stuthridge,T.R. and
Dietrich,D.R. (2003). In vivo and in vitro assessment of the androgenic potential of a pulp and
paper mill effluent. Environ. Toxicol. Chem. 22(7), pp. 1448-1456.
Ericson,G. and Larsson,Å. (2000). DNA Adducts in Perch (Perca fluviatilis) Living in Coastal Water
Polluted with Bleached Pulp Mill Effluents. Ecotoxicol. Environ. Saf. 46(2), pp. 167-173.
Evans,J.J. (1997). Rubber tire leachate in the aquatic environment. Rev. Environ. Contam. Toxicol.
151, pp. 67-115.
Ferreira-Leach,A.M.R. and Hill,E.M. (2001). Bioconcentration and distribution of 4-tert-octylphenol
residues in tissues of the rainbow trout (Oncorhynchus mykiss). Marine Environ. Res. 51, pp. 75-89.
Foale,S. (1993). An evaluation of the potential of gastropod imposex as a bioindicator of tributyltin
pollution in Port Phillip Bay, Victoria. Marine Pollution Bulletin 26(10), pp. 546-552.
Folmar,L.C., Denslow,N.D., Rao,V., Chow,M., Crain,D.A., Enblom,J., Marcino,J. and Guilette,L.J.
(1996). Vitellogenin induction and reduced serum testosterone concentration in feral male carp
(Cyprinos carpio) captured near a major metropolitan sewage treatment plant. Environ. Health
Perspect. 104, pp. 1096-1101.
Foran,C.M., Bennett,E.R. and Benson,W.H. (2000). Developmental evalution of a potenial nonsteroidal estrogen: triclosan. Marine. Environ. Res. 50, pp. 153-156.
Förlin,L. and Haux,C. (1985). Increased excretion in the bile of 17β-[3H]estradiol-derived radioactivity
in rainbow trout treated with β-naphtoflavone. Aquat. Toxicol. 6(3), pp. 197-208.
22
Förlin,L. and Wachtmeister,C.A. (1989). Fish bile analysis for monitoring of low concentrations of
polar xenobiotics in water. In Landner, L. (Ed.). Chemicals in the aquatic environment: Advanced
hazard assessment. Springer series on environmental management. Berlin, Springer-Verlag (7),
150-164.
Gibson,R., Tyler,C.R. and Hill,E.M. (2005). Analytical methodology for the identification of
estrogenic contaminants in fish bile. J. Chromatogr. A 1066, pp. 33-40.
Glickman,A.H., Statham,C.N., Wu,A. and Lech,J.J. (1977). Studies on the uptake, metabolism, and
disposition of pentachlorophenol and pentachloroanisole in rainbow trout. Toxicol. Appl.
Pharmacol. 41, pp. 649-658.
Gold,L.S., Slone,T.H., Stern,B.R. and Bernstein,L. (1993). Comparison of target organs of
carcinogenicity for mutagenic and non-mutagenic chemicals. Mutation Res. 286, pp. 75-100.
Hartwell,S.I., Jordahl,D.M. and Dawson,C.E.O. (2000). The effect of salinity on tire leachate toxicity.
Water, Air, and Soil Pollution 121, pp. 119-131.
Haux,C., Sjoebeck,M.L. and Larsson,A. (1985). Physiological stress responses in a wild fish
population of perch (Perca fluviatilis) after capture and during subsequent recovery. Marine
Environmental Research 15(2), pp. 77-95.
Holmbom,B. and Lehtinen,K.J. (1980). Acute toxicity to fish of kraft pulp mill waste waters. Paperi
Puu 62, pp. 673-684.
Houtman,C.J., van Oostveen,A.M., Brouwer,A., Lamoree,M.H. and Legler,J. (2004). Identification of
estrogenic compounds in fish bile using bioassay-directed fractionation. Environ. Toxicol. Chem.
38, pp. 6415-6423.
Howell,W.M., Black,D.A. and Bortone,S.A. (1980). Abnormal expression of secondary sex characters
in a population of mosquitofish, Gambusia affins holbrooki: Evidence for environmentally-induced
masculinization. Copeia 4, pp. 676-681.
Hunter,G.A. and Donaldson,E.M. (1983). Hormonal sex control and its application to fish culture. IX,
223-303. New York, Academic Press.
Ishibashi,H., Matsumura,N., Hirano,M., Matsuoka,M., Shiratsuchi,H., Ishibashi,Y., Takao,Y. and
Arizono,K. (2004). Effects of triclosan on the early life stages and reproduction of medaka Oryzias
latipes and induction of hepatic vitellogenin. Aquat. Toxicol. 67, pp. 167-179.
Jensen,S. and Renberg,L. (1972). Contaminants in pentachloropheno1 chlorinated hydroxydiphenyl
ethers. Ambio 1(2), pp. 62-65.
Jobling,S., Reynolds,T., White,R., Parker,M.G. and Sumpter,J.P. (1995). A variety of environmental
persistent chemicals, including some phtalate plasticizers, are weakly estrogenic. Environ. Health
Perspect. 103 (6), pp. 582-587.
Johnsen,K., Tana,J., Lehtinen,K.-J., Stuthridge,T., Mattson,K., Hemming,J. and Carlberg,G.E. (1998).
Expirimental field exposure of brown trout to river water receiving effluent from an integrated
newsprint mill. Ecotox. Environ. Saf. 40, pp. 184-193.
Jonsson,G., Beyer,J., Wells,D. and Ariese,F. (2003). The application of HPLC_F and GC-MS to the
analysis of selected hydroxy polycyclic hydrocarbons in two certified fish bile reference materials.
J. Environ. Monit. 5, pp. 513-520.
Kanetoshi,A., Ogawa,H., Katsura,E. and Kaneshima,H. (1988). Formation of polychlorinated dibenzop-dioxins upon combustion of commercial textile products containing 2,4,4´-trichloro-2´hydroxydiphenyl ether (Irgasan DP300). J. Chromatogr. 442, pp. 289-299.
23
Kanetoshi,A., Ogawa,H., Katsura,E., Kaneshima,H. and Miura,T. (1988). Formation of polychlorinated
dibenzo-p-dioxin from 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan DP300) and its
chlorinated derivatives by exposure to sunlight. J.Chromatogr. 454, pp. 145-155.
Katsiadaki,I., Scott,A.P., Hurst,M.R., Matthiessen,P. and Mayer,I. (2002). Detection of environmental
androgens: a novel method based on enzyme-linked immunosorbent assay of spiggin, the
stickleback (Gasterosteus aculeatus) glue protein. Environ. Toxicol. Chem. 21(9), pp. 1946-1954.
Knudsen,F.R., Schou,A.E., Wiborg,M.L., Mona,E., Tollefsen,K.-E., Stenersen,J. and Sumpter,J.P.
(1997). Increase of plasma vitellogenin concentration in rainbow trout (Oncorhynchus mykiss)
exposed to effluents from oil refinery treatment works and municipial sewage. Bull. Environ.
Contam. Toxicol. 58, pp. 802-806.
Kolpin,D.W., Furlong,E.T., Meyer,M.T., Thurman,E.M., Zaugg,S.D., Barber,B.L. and Buxton,H.T.
(2002). Pharmaceuticals, hormones, and other organic contaminants in U.S. streams, 1999-2000: A
national reconnaissance. Environ. Sci. Technol. 36, pp. 1202-1211.
Kovacs,T.G., Gibbons,J.S., Martel,P.H. and Voss,R.H. (1996). Improved effluent quality at a bleached
kraft mill as determined by laboratory biotests. Journal of Toxicology and Environmental Health
49(5), pp. 533-561.
Krahn,M.M., Myers,M.S., Burrows,D.G. and Malins,D.C. (1984). Determination of metabolites of
xenobiotics in the bile of fish from polluted waterways. Xenobiotica 14 (8), pp. 633-646.
Krotzer,M.J. (1990). The effects of induced masculinization on the reproductive and aggresive
behaviours of the female mosquitofish, gambusia affins affins. Environ. Biol. Fish 29, pp. 127-134.
Landner,L., Grahn,O., Härdig,J., Lehtinen,K.-J., Monfelt,C. and Tana,J. (1994). A field study of
environmental impacts at a bleached kraft pulp mill site on the Baltic sea coast. Ecotox. Environ.
Saf. 27, pp. 128-157.
Larsson,D.G.J., Adolfsson-Erici,M., and Thomas,P. (2005). Characterization of putative ligands for a
fish gondal androgen receptor in a pulp mill effluent. Submitted.
Larsson,D.G.J., Hällman,H. and Förlin,L. (2000). More male fish embryos near a pulp mill. Environ.
Toxicol. Chem. 19(12), pp. 2911-2917.
Larsson,D.G.J. and Förlin,L. (2002). Male-biased sex ratios of fish embryos near a pulp mill:
temporary recovery after a short-term shutdown. Environmental health perspectives 110(8), pp.
739-742.
Larsson,D.G.J., Kinnberg,K., Sturve,J., Stephensen,E., Skon,M. and Förlin,L. (2002). Studies of
masculinization, detoxification, and oxidative stress responses in guppies (Poecilia reticulata)
exposed to effluent from a pulp mill. Ecotox. Environ. Saf. 52(1), pp. 13-20.
Larsson,Å., Förlin,L., Lindesjöö,E. and Sandström,O. (2003). Monitoring of individual organism
responses in fish populations exposed to pulp mill effluents. 216-226.
Latch,D.E., Packer,J.L., Arnold,W.A. and McNeill,K. (2003). Photochemical conversion of triclosan to
2,8-dichlorodibenzo-p-dioxin in aqueous solution. J. Photochem. Photobiol. 158, pp. 63-66.
Leach,J.M. and Thakore,A.N. (1977). Compounds toxic to fish in pulpm waste streams. Prog. Wat.
Vol. 9, pp. 787-798.
Leadly,T.A., Arcand-Hoy,L.D., Haffner,G.D. and Metcalfe,C.D. (1999). Fluorescent aromatic
hydrocarbons in bile as a biomarker of exposure of Brown bullheads ( Ameiurus nebulosus ) to
contaminated sediments. Environ. Toxicol. Chem. 18(4), pp. 750-755.
24
Lech,J.J. (1973). Isolation and indentification of 3-trifluoromethyl-4-nitrophenyl glucuronide from bile
of rainbow trout exposed to 3-trifluoromethyl-4-nitropkenol. Toxicol. Appl. Pharmacol. 24, pp.
114-124.
Lee,H.B. and Peart,T.E. (1990). Gas chromatographic and mass spectrometric determination of some
resin and fatty acids in pulp mill effluents as their pentafluorobenzyl ester derivatives. J.
Chromatogr. 498, pp. 367-379.
Legler,J., Jonas,A., Lahr,J., Vethaak,A.D., Brouwer,A. and Murk,A.J. (2002). Biological measurement
of estrogenic activity in urine and bile conjugates with the in vitro ER-CALUX reporter gene assay.
Environ. Toxicol. Chem. 21(3), pp. 473-479.
Leonard,J.D. and Hellou,J. (2001). Separation and characterization of gall bladder bile metabolites
from speckeld trout, Salvelinus fontinalis, exposed to individual polycyclic aromatic compounds.
Environ. Toxicol. Chem. 20 (3), pp. 618-623.
Levy,C.W., Roujeinikova,A., Sedelnikova,S., Baker,P.J., Stuitje,A.R., Slabas,A.R., Rice,D.W. and
Rafferty,J.B. (1999). Molecular basis of triclosan activity. Nature 398, pp. 383-384.
Lindholst,C., Pedersen,K.L. and Pedersen,S.E. (2000). Estrogenic responses of bisphenol A in rainbow
trout (Oncorhynhus mykiss). Aquat. Toxicol. 48 (2-3), pp. 87-94.
Lopez de Alda,M.J. and Barcelo,D. (2001). Review of analytical methods for the determination of
estrogens and progestogens in waste waters. Fresenius' J. Anal. Chem. 371(4), pp. 437-447.
Malins,D.C., Krahn,M.M., Myers,M.S., Rhodes,L.D., Brown,D.W., Krone,C.A., McCain,B.B. and
Chan,S.-L. (1985). Toxic chemicals in sediments and biota from a creosote-polluted harbor:
relationships with hepatic neoplasms and other hepatic lesions in english sole ( Parophyrs vetulus ).
Carcinogenesis 6(10), pp. 1463-1469.
Malins,D.C., McCain,B.B., Brown,D.W., Varanasi,U., Krahn,M.M., Myers,M.S. and Chan,S.-L.
(1987). Sediment-associated contaminants and liver dieseases in bottom-dwelling fish.
Hydrobiologia 149, pp. 67-74.
McAvoy,D.C., Schatowitz,B., Jacob,M., Hauk,A. and Eckhoff,W.S. (2002). Measurement of triclosan
in wastewater treatment systems. Environ. Toxicol. Chem. 21(7), pp. 1323-1329.
McMurry,L.M., Oethinger,M. and Levy,S.B. (1998). Triclosan targets lipid synthesis. Nature 394, pp.
531-532.
Melancon,M.J.J. and Lech,J.J. (1976). Distribution and biliary excretion products of Di-2-ethylhexyl
phthalate in rainbow trout. Drug. Metabol. Disp. 4(2), pp. 112-118.
Melancon,M.J., Jr. and Lech,J.J. Isolation and identification of a polar metabolite of
tetrachlorobiphenyl from bile of rainbow trout exposed to 14C-tetrachlorobiphenyl. Bull. Environ.
Contam. Toxicol. 15(2), pp. 181-188.
Mezcua,M., Gómez,M.J., Ferrer,I., Agüera,A., Hernando,M.D. and Fernández-Alba,A.R. (2004).
Evidence of 2,7/2,8-dibenzodichloro-p-dioxin as a photodegradation product of triclosan in water
and wastewater samples. Analytica Chimica Acta 524, pp. 241-247.
Miyazaki,T., Yamagishi,T. and Matsumoto,M. (1984). Residues of 4-chloro-1-(2,4-dichlorophenoxy)2-methoxybenzene(triclosan methyl) in aquatic biota. Bull. Environ. Contam. Toxicol. 32, pp. 227232.
Murin,M., Gavora,J., Drastichova,I., Duskova,E., Madsen,T., Torslov,J., Damborg,A., Tyle,H. and
Pedersen,F. (1997). Aquatic hazard and risk assessment of two selected substances produced in
high volumes in the Slovak republic. Chemophere 34 (1), pp. 179-190.
25
Myers,M.S., Landahl,J.T., Krahn,M.M. and McCain,B.B. (1991). Relationships between hepatic
neoplasms and related lesions and exposure to toxic chemicals in marine fish from the U.S west
coast. Environ. Health Perspect. 90, pp. 7-15.
Oikari,A. and Holmbom,B. (1986). Assessment of water contamination by chlorophenolics and resin
acids with the aid of fish bile metabolites. ASTM Special Technical Publication (Aquat. Toxicol.
Environ. Fate:9th Vol. ) 921, pp. 252-267.
Oikari,A. and Kunnamo- Ojala,T. (1987). Tracing of xenobiotic contamination in water with the aid of
fish bile metabolites: a field study with caged rainbow trout (Salmo gairdneri). Aquat. Toxicol. 9,
pp. 327-341.
Oikari,A. and Ånäs,E. (1985). Chlorinated phenolics and their conjugates in the bile of trout (Salmo
gairdneri) exposed to contaminated waters. Bull. Environ. Contam. Toxicol. 35, pp. 802-809.
Oikari,A.O.J. (1988). Determination and characterization of chloroguaiacol conjugates in fish bile by
HPLC. Environ. Pollution. 55, pp. 79-87.
Orvos,D.R., Versteeg,D.J., Inauen,J., Capdevielle,M., Rothenstein,A. and Cunningham,V. (2002).
Aquatic toxicity of triclosan. Environ. Toxicol. Chem. 21(7), pp. 1338-1349.
OSPAR/ICES. (1995). Report of the workshop on biological effects monitoring techniques. Aberdeen,
Oct 2-6.
Owens,J.W., Swanson,S.M. and Birkholz,D.A. (1994). Environmental monitoring of bleached kraft
pulp mill chlorophenolic compounds in a northern Canadian river system. Chemosphere 29(1), pp.
89-109.
Palmér,L. and Kolmodin-Hedman,B. (1972). Improved quantitative gas chromatographic method for
the analysis of small amounts of chlorinated hydrocarbon pesticides in human plasma. J.
Chromatogr. 74, pp. 21-30.
Panter,G.H., Thompson,R.S., Beresford,N. and Sumpter,J.P. (1999). Transformation of a nonoestrogenic steroid metabolite to an oestrogenically active substance by minimal bacterial activity.
Chemophere 38 (15), pp. 3579-3596.
Peters,L.D., Morse,H.R., Waters,R. and Livingstone,D.R. (1997). Responses of hepatic cytochrome
P450 1A and formation of DNA adducts in juveniles of turbot (Scophthalmus maximus L.) exposed
to water-borne benzo[a]pyrene. Aquat. Toxicol 38 (1-3), pp. 67-82.
Powers,D.A. (1989). Fish as a model system. Science 246, pp. 352-358.
Purdom,C.E., Hardiman,P.A., Bye,V.J., Eno,N.C., Tyler,C.J. and Sumpter,J.P. (1994). Estrogenic
effects from sewage treatment works. Chem. Ecol 8, pp. 275-285.
Ranney,R.E. (1977). Comparative metabolism of 17α-ethynyl steroids used in oral contraceptives. J.
Toxicol. Environ. Health 3, pp. 139-166.
Richardson,D.M., Davies,I.M., Moffat,C.F., Pollard,P.M. and Stagg,R.M. (2001). Bilary PAH
metabolites and EROD activity in flounder (Platichtys flesus) from a contaminated estuarine
environment. J. Environ. Monit. 3, pp. 610-615.
Richardson,D.M., Gubbins,M.J., Davies,I.M., Moffat,C.F. and Pollard,P.M. (2004). Effects of feeding
status on biliary PAH metabolite and biliverdin concentrations in plaice (Pleuronectes platessa).
Environ. Toxicol. Pharmacol. 17, pp. 79-85.
Routledge,E.J., Sheahan,D., Desbrow,C., Brightly,G.C., Waldock,M. and Sumpter,J.P. (1998).
Identification of estrogenic chemicals in STW effluents. 2. In vivo responses in trout and roach.
Environ. Sci. Technol. 32, pp. 1559-1565.
26
Ruddock,P.J., Bird,D.J. and McCalley,D.V. (2002). Bile metabolites of polycyclic aromatic
hydrocarbons in three species of fish from the severn estuary. Ecotox. Environ. Saf. 51, pp. 97-105.
Rudling,L. (1970). Determination of pentachlorophenol in organic tissues and water. Wat. Res. 4, pp.
533-537.
Sandström,O. (1994). Incomplete recovery in a coastal fish community exposed to effluent from a
modernized Swedish bleached kraft mill. Can. J. Fish. Aquat. Sci. 51, pp. 2195-2202.
Sandvik,M., Horsberg,T.E., Utne Skaare,J. and Ingebrigtsen,K. (1998). Comparison of diatary and
waterborne exposure to benzo(a)pyrene: bioavailability, tissue disposition and CYP1A1 induction
in rainbow trout (Oncorhynchus mykiss). Biomarkers 3 (6), pp. 399-410.
Schweizer,H.P. (2001). Triclosan: a widely used biocide and its link to antibiotics. FEMS
Microbiology Letters 202, pp. 1-7.
Singer,H., Müller,S., Tixier,C. and Pillonel,L. (2002). Triclosan: occurence and fate of a widely used
biocide in the aquatic environment: field measurements in wastewater treatment plants, surface
waters and lake sediments. Environ. Sci. Technol. 36, pp. 4998-5004.
Sioufi,A., Caudal,F. and Grimault,D. (1977). GLC determination of free and conjugated triclosan in
human plasma and urine. J. Pharm. Sci. 66(8), pp. 1166-1168.
Soimauo,R., Jokinen,I., Kukkonen,J., Petänen,T., Ristola,T. and Oikari,A. (1995). Biomaker Responses
along a Pollution Gradient: Effects of Pulp and Paper Mill Effluents on Caged Whitefish. Aquat.
Toxicol. 31, pp. 329-345.
Spies,R.B., Andersen,B.D. and Rice Jr,D.W. (1987). Benzothiazoles in estuarine sediments as
indicators of street runoff. Nature 327, pp. 697-699.
Stephensen,E., Adolfsson-Erici,M., Hulander,M., Parkkonen,J. and Förlin,L. (2005). Rubber additives
induce oxidative stress in rainbow trout. Aquat. Toxicol. Submitted.
Steward,A.R., Maslanka,R., Kumar,S. and Sikka,H.C. (1992). Metabolism of 2,3,7,8Tetrachlorodibenzofuran by rainbow trout (Oncorhynchus Mykiss). Chemosphere 25, pp. 12151220.
Sturve,J., Balk,L., Broeg,K., Böhmert,B., Parkkonen,J., Koehler,A., Adolfsson-Erici,M., and Förlin,L.
(2005). Effects of an oil spill in Göteborg harbor, Sweden assessed by biomarkers in eelpout
(Zoarces viviparus). Manuscript.
Sumpter,J.P. and Jobling,S. (1995). Vitellogenesis as a biomarker for contamination of the aquatic
environment. Environ. Health Perspect. 3 suppl 7, pp. 173-178.
Söderström,M., Wachtmeister,C.A. and Förlin,L. (1994). Analysis of chlorophenolics from bleach kraft
mill effluents (BKME) in bile of perch (Perca fluviatilis) from the Baltic Sea and development of
an analytical procedure also measuring chlorocatechols. Chemophere 28 (9), pp. 1701-1719.
Ternes,T., Stumpf,M., Mueller,J.C., Haberer,K., Wilken,R.-D. and Servos,M. (1999a). Behaviour and
occurence of estrogens in municipal sewage treatment plants - I. Investigations in Germany, Canada
and Brazil. Sci. Tot. Environ 225, pp. 81-90.
Ternes,T., Kreckel,P. and Mueller,J.C. (1999b). Behaviour and occurence of estrogens in municipal
sewage treatment plants - II. Aerobic batch experiments with activated sludge. Sci. Tot Environ.
225, pp. 91-99.
Thibaut,R., Debrauwer,L., Rao,D. and Cravedi,J.P. (1998). Disposition and metabolism of [3H]-4-nnonylphenol in rainbow trout. Marine Environ. Res. 46 (1-5), pp. 521-524.
27
Thorpe,K.L., Cummings,R.I., Hutchinson,T.H., Scholze,M., Brightly,G.C., Sumpter,J.P. and
Tyler,C.R. (2003). Relative potencies and combination effects of steriodal estrogens in fish.
Environ. Sci. Technol. 37, pp. 1142-1149.
Van den Belt,K., Berckmans,P., Vangenechten,C., Verheyen,R. and Wtters,H. (2004). Comparative
study on the in vitro/in vivo estrogenic potencies of 17b-estradiol, estrone, 17a-ethynylestradiol and
nonylphenol. Aquat. Toxicol. 66, pp. 183-195.
Van der Oost,R., Beyer,J. and Vermeulen,N.P.E. (2003). Fish bioaccumulation and biomarkers in
environmental risk assessment: a review. Environ. Toxicol. Pharmacol. 13, pp. 57-149.
Van der Oost,R., Schooten,F.-J., Ariese,F., Heida,H., Satumalay,K. and Vermeulen,N.P.E. (1994).
Bioaccumulation, biotransformation and DNA binding of PAHs in feral eel (Anguilla anguilla)
exposed to polluted sediments: A field survey. Environ. Toxicol. Chem. 13 (6), pp. 859-870.
Van Schanke,A., Holtz,F., Van der Meer,J., Boon,J.P., Ariese,F., Stroomberg,G., Van den Berg,M. and
Everaarts,J.M. (2001). Dose- and time-dependet formation of bilary benzo(a)pyrene metabolites in
the marine flatfish Dab (Limanda limanda). Environ. Toxicol. Chem. 8, pp. 1641-1647.
Vermeulen,G.J., Lambert,J.G.D., Lenczowski,M.J.P. and Goos,H.J.T. (1993). Steroid hormone
secretion by testicular tissue from African catfish, Clarias gariepinus, in primary culture:
Identification and quantification by gas chromatography-mass spectrometry. Fish Physiol.
Biochem. 12(1), pp. 21-30.
Vethaak, A. D, Rijs, G. B. J., Schrap, S. M., Ruiter, H., Gerritsen, A., and Lahr, J. (2002). Estrogens
and xeno-estrogens in the aquatic environment of The Netherlands. Occurence, potency and
biological effects. RIZA/RIKZ Report 2002/001. Den Haag.
Von Rathner,M. and Sonneborn,M. (1979). Biologishe wirksamme Oestrogene in Trink- und
Abwasser. Forum Staedte. Hyg. 30, pp. 45-49.
Wahli,T., Meier,W., Segner,H. and Burkhart-Holp,P. (1998). Immunohistochemical detection of
vitellogenin in male brown trout from Swiss rivers. Histochem. J. 30(10), pp. 753-758.
Walsh,K., Dunstan,R.H. and Murdoch,R.N. (1995). Differential bioaccumulation of heavy metals and
organopollutants in the soft tissue and shell of the marine gastropod, Austrocochlea constricta.
Arch. Environ. Contam. Toxicol. 28, pp. 35-39.
Wik,A. and Dave,G. (2005). Environmental labeling of car tires - toxicity to Daphnia magna can be
used as a screening method. Chemophere 58, pp. 645-651.
Williamson,D., Winterbourn,C.C., Swallow,W.H. and Missen,A.W. (1981). Oxidative hemoglobin
breakdown induced by a rubber additive. Hemoglobin 5, pp. 73-84.
Yang,X., Peterson,D.S., Baumann,P.C. and Lin,E.L.C. (2003). Fish biliary PAH metabolites estimated
by fixed-wavelength fluorescence as an indicator of environmental exposure and effects. Internat.
Assoc. Great Lakes Res. 29(1), pp. 116-123.
28