Ilaria Rinaldi

14th International Conference on Nuclear
Reaction Mechanisms, Varenna
18th June 2015
Status and perspective of emission
imaging techniques for ion beam
therapy in Lyon
Ilaria Rinaldi
on behalf of the CAS-PHABIO group of IPNL
Lyon 1 University and CNRS/IN2P3, France
Rationale for ion therapy and range verification
Present
• Reduced integral dose (factor ~3)
Healthy
Tissues
Paganetti AAPM 2012
Tumor
Target
Tumor volume
Organ at risk
Future
• Reduction of safety margins
• (dose escalations; higher cure rate)
• Use of new irradiation fields
• (use of sharp distal penumbra of Braggpeaks)
Tang et. al. Med.Phys. 2012
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How do we reduce range uncertainties?
• In-vivo range verification
PET
Prompt gamma cameras
• Increasing accuracy in range prediction
Ion CT
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Prompt gamma
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Prompt gamma based range verification
Projectile
Nucleons
and clusters
Projectile fragment
Fireball
•
Target
• Prompt gamma
Target fragment
75, 95 MeV/u 12C ions on PMMA
160 MeV protons on PMMA
• TOF background
discrimination
• BP position
• BP position
• BP position
ENVISION collaboration: Dauvergne et al (IPNL Lyon), Prieels et al (IBA)
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Collimated cameras in Lyon
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Prompt gamma profiles: TOF influence
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Multislit collimator in Lyon
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Multislit collimator in Lyon
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Compton camera in Lyon
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Gamma cameras in Lyon: Hodoscope
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Compton camera in Lyon: Scatter detector
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Gamma cameras in Lyon: Absorber
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IVI
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Interaction vertex imaging (IVI)
Projectile
Projectile fragment
Fireball
Target
Nucleons and
clusters
Target fragment
Secondary charged
particles (e.g, proton)
Dauvergne et al 2009
AQUA Project: G4 simulations
07.05.2015
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IVI in Lyon: Detectors
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IVI in Lyon: Set-ups
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IVI in Lyon: Measurements (GSI)
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IVI in Lyon: Measurements (GSI)
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IVI in Lyon: MC/Measurements (HIT)
R. Rescigno et al, ICTR-PHE 2014
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Summary
Imaging – range verification
Hardware development
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Monte Carlo simulations
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Thank you
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Backup
07.05.2015
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Prompt gammas
CAS-Phabio IPN-Lyon
Multi-slit Prompt-gamma camera
p 160 MeV on PMMA
PG without TOF
PG with TOF
Diff with/without TOF
Compton camera
Roellinghoff et.al. Phys. Med. Biol. 59 (2014)
• Monte Carlo as a tool for feasibility
and detector design studies
• Detection set-up characterization and
optimization in clinical conditions
• Clinical validation of real time range
verification
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Monte Carlo validation
3
p 160 MeV on MLFC
p 160 MeV on PMMA
2
Smeets et al., PMB 57 (2012)
2
2
3
2
Rinaldi et al., PMB 56 (2011), 4001
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Ferrari, Rinaldi et al., in preparation
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Range resolution with prompt gammas
1-sigma of a distributions of fall-off positions
Roellinghoff et.al. Phys. Med. Biol. 59 (2014)
- 1 mm precision with 2E+09 protons, TOF selection and small detector (4 cm high)
for an homogeneous target
- Increase of the solid angle by a factor 10: Millimetric precision on a pencil beam
basis
- For distal spots ~2x108 protons/spot
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IVI techniques
“Single-proton” imaging (SP-IVI)
Intersection of a secondary-proton
trajectory with the incident-ion
trajectory
“Double-proton” imaging (DP-IVI)
Intersection of 2 secondary-proton
trajectories
Detectors
Tracker (CMOS) + beam hodoscope
(in coincidence)
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Courtesy of E. Testa
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IVI perspectives
In-beam tests with
CMOS detectors:
• GANIL (95 MeV/u)
• HIT (200-300 MeV/u)
QAPIVI project
(IPNL+IPHC)
Courtesy of E. Testa
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IVI perspectives
Henriquet et.al. PMB 2012
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Gwosch et.al. PMB 2013
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How to measure prompt gamma
Collimated camera
single and multislit
Common device: Hodoscope
Ray (IPN Lyon)
Hardware
- array of scintillating
fibres (1x1 mm2)
- 2 prototypes: 2x32 and
2x128 fibres
- time resolution ≤ 1 ns
- goal: count rates up to
108 1/s
Compton camera
electronic collimation
Ray (IPN Lyon)
Electronics
- development of ASIC
- new version with DLL
⇒ timing
Krimmer and De Rydt (IPN Lyon)
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