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curriculum vitae - Università degli Studi di Milano
Eduardo Nobile-Orazio 1 CURRICULUM VITAE DEL PROF. EDUARDO NOBILE-ORAZIO DATI ANAGRAFICI Nome e cognome: Luogo di nascita: Data di nascita: Cittadinanza: Domicilio: Eduardo Nobile-Orazio Bologna 26 settembre 1953 Italiana Milano, Via De Albertis 11, 20129. Tel. 0270124894 Indirizzo di lavoro: Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università di Milano Neurologia 2, IRCCS Istituto Clinico Humanitas Via Manzoni 56, 20089 Rozzano (Milano). Tel. 02-8224.2209 FAX. 02-8224.2298 e-mail: [email protected]; [email protected] Stato Civile: Coniugato (Beatrice Aliverti) Lingue: Inglese, Francese STUDI UNIVERSITARI 13/7/1978 9/11/1982 5/10/1987 Laurea in Medicina e Chirurgia 110/110 e lode Universita' degli Studi, Milano. Tesi: Ruolo del linguaggio nei giudizi di somiglianza visiva. Relatore: prof. E. Bisiach. Specializzazione in Neurologia 70/70 e lode Universita' degli Studi, Milano. Tesi: Profilo delle IgG seriche e liquorali nel corso di Sindrome di Guillain Barré. Relatore: prof. G. Scarlato. Dottorato di Ricerca in Scienze Neurologiche Universita' degli Studi, Milano. Tesi: Polineuropatia in corso di macroglobulinemia: incidenza e correlazione con la specificita' antigenica della paraproteina. ATTIVITÀ CLINICO-ASSISTENZIALE 17/7/197828/2/1982 1/11/198331/10/1986 15/7/198729/1/1993 Specializzando in Neurologia Istituto di Clinica Neurologica, Universita' degli Studi, Milano Borsista dell'Universita' di Milano, per il Dottorato di Ricerca in Scienze Neurologiche. Assistente Medico Neurologo, Ospedale Maggiore Policlinico di Milano, Ist. Clinica Neurologica, (dal 1/9/1987 a tempo pieno;dal 19/7/1988 di ruolo). 29/1/93-30/9/01 Aiuto Corresponsabile Neurologo (ora Dirigente di I Livello, fascia A) a tempo pieno, Ospedale Maggiore Policlinico di Milano, Ist. Clinica Neurologica, 1/10/01-30/5/04 Professore Associato di Neurologia- Dirigente medico I° livello Unità di Neurologia, IRCCS Ospedale Maggiore Policlinico di Milano 01/06/04-tuttora Professore Associato di Neurologia- Responsabile di Unità Operativa Neurologia II, IRCCS Istituto Clinico Humanitas, Rozzano (Milano) ATTIVITA' DIDATTICA 1988/89-00/01 Professore a contratto di Neuroimmunologia Clinica Scuola di Specializzazione in Neurologia Universita' Studi di Milano. Eduardo Nobile-Orazio 2 01/10/0101/11/0231/10/07 Professore Associato di Neurologia (MED/26) Diparimento di Scienze Neurologiche, Università degli Studi di Milano Segretario della Scuola di Specializzazione di Neurologia Università di Milano ATTIVITA' SCIENTIFICA Attività di ricerca svolta presso Centri Italiani e relativa qualifica 1/11/1983Borsista per il Dottorato di Ricerca in Scienze Neurologiche 31/10/1986 Universita' di Milano, Istituto di Clinica Neurologica 15/7/987-31/5/04 Responsabile del Gruppo/Laboratorio di ricerca di Neuroimmunologia IRCCS Ospedale Maggiore Policlinico di Milano, Istituto di Clinica Neurologica, con i seguenti inquadramenti: Borse di Studio e Attività di ricerca all’estero 1/3/198230/6/1984 1/7/198330/6/1984 "Visiting Fellow", c/o: Dip. di Neurologia, Columbia University, New York, N.Y., USA "Post-doctoral Research Fellow", National Multiple Sclerosis Society, USA c/o: Dip. di Neurologia, Columbia University, New York, NY, USA. Pubblicazioni: 577 pubblicazioni di interesse neurologico (vedi allegato elenco) di cui: 177 articoli (174 in inglese) di cui 169 con Impact Factor (IF totale 2012: 974,120) 19 capitoli o relazioni in esteso pubblicate su libri di cui 11 in inglese; 284 riassunti di comunicazioni a congressi pubblicati su riviste internazionali di cui 272 su riviste indicizzate; 28 relazioni in esteso a congressi o seminari su atti/dispense/CD (26) o riviste (2); 70 riassunti di comunicazioni a congressi pubblicati su Atti di Congressi. Partecipazioni a Congressi: 238 partecipazioni a congressi e corsi di aggiornamento neurologici (vedi allegato elenco) come relatore/coautore in 208 (invitato in 124), moderatore in 76, organizzatore in 5, di cui: 123 nazionali, 115 internazionali. 53 Seminari e Conferenze ad invito (esclusi i Congressi) Membro dell’Editorial Board delle seguenti Riviste Neurological Sciences, Milano, Italia Muscle & Nerve, USA Expert Review of Neurotherapeutics, UK Journal of the Peripheral Nervous System, NY, USA Neurology and Clinical Neuroscience, Japan INCARICHI DIRETTIVI IN SOCIETA’ SCIENTIFICHE 1993-1996 1997-2010 2001-2005 Membro del Comitato Direttivo dell’Associazione Italiana di Neuropatologia. Membro del Comitato Scientifico del Gruppo Italiano di Studio delle Neuropatie Periferiche Coordinatore del Gruppo Italiano di Studio delle Neuropatie Periferiche Eduardo Nobile-Orazio 3 1998-2003 2000-2002 2001-2005 2003-2007 2001-2011 20072009-2011 2011-2013 20132013- Membro del Comitato Direttivo dell’ Associazione Italiana di Neuroimmunologia Membro del “Quality Standards Sucommittee of the American Academy of Neurology on the Usefulnes of anti-GM1 antibodies in Lower Motor Neuron Syndrome”. Membro dell’Executive Commitee dell’European Neurological Society (dal 2003 al 2005 Director of the Teaching Courses) Membro del Board of Director della Peripheral Nerve Society Chairman del Guideline Committee della Peripheral Nerve Society Membro dell’Organizing Committee dell’Inflammatory Neuropathy Consortium (INC) della Peripheral Nerve Society President Elect, Peripheral Nerve Society President, Peripheral Nerve Society Past-President, Peripheral Nerve Society Membro del Medical Advisory Board dell GBS-CIDP Foundation Interantional AFFILIAZIONE A SOCIETA' 1989-1999 1988-2005 198919911994199619982012- Associazione Italiana di Neuropatologia Gruppo Italiano di Neuroimmunologia (Ass. Italiana di Neuroimmunologia) European Neurological Society Società Italiana di Neurologia Peripheral Nerve Society Gruppo di Studio (ora Associazione) sul Sistema Nervoso Periferico. American Academy of Neurology, Correspondig Fellow American Neurological Association, Correspondig Fellow Milano 11/03/2014 Prof. Eduardo Nobile-Orazio PUBBLICAZIONI a) Lavori pubblicati su riviste scientifiche (IF 2012) 1. 2. 3. 4. 5. 6 7 Nobile-Orazio E, Sterzi R. Cerebral Ischemia after Nifedipine treatment. British Medical Journal. 1981; 283: 948-949. IF: 13.660 Valli G, Ferini Strambi L, Nobile-Orazio E, Scarlato G. Idiopathic inflammatory polyradiculoneuropathy: evaluation of clinical and laboratory data and therapeuthic considerations. Italian Journal of Neurological Sciences 1983; 1: 19-26. IF: 1.412 Nobile-Orazio E, Vietorisz T, Messito MJ, Sherman W, Latov N Anti-MAG IgM antibodies in patients with neuropathy and IgM M-proteins: detection by ELISA. Neurology 1983; 33: 939-942. IF: 8.249 Nobile-Orazio E, Latov N, Hays AP, Takatsu M, Abrams G, Sherman WH, Miller JR, Messito MJ, Saito T, Tahmoush A,Lovelace RE, Rowland LP. Neuropathy and anti-MAG antibodies without detectable serum M-protein. Neurology 1984; 34: 218-221. IF: 8.249 Nobile-Orazio E, Hays AP, Latov N, Perman G, Golier G, Shy ME, Freddo L. Specificity of mouse and human monoclonal antibodies to the myelin associated glycoprotein. Neurology 1984; 34: 1336-1342. IF: 8.249 Shy ME, Vietorisz T, Nobile-Orazio E, Latov N. Specificity of human IgM M-proteins that bind to myelin associated glycoprotein: peptide mapping, deglycosylation and competitive binding studies. Journal of Immunology 1984; 133: 2509-2512. IF: 5.520 Nobile-Orazio E, McIntosh C, Latov N. Eduardo Nobile-Orazio 4 8. 9. 10. 11. 12. 13. 14. 15. 16. 17 18. 19. 20. 21. 22. Anti-MAG antibodies and antibody complexes: detection by radioimmunoassay. Neurology 1985; 35: 988-992. IF: 8.249 Latov N, Godfrey M, Thomas Y, Nobile-Orazio E, Spatz L, Abraham J, Perman G, Freddo L,Chess L Neuropathy and anti-MAG IgM M-proteins: T cell regulation and M-protein secretion in vitro. Annals of Neurology 1985; 18: 182-188. IF: 11.193 Takatsu M, Hays AP, Latov N, Abrams GM, Nemni R, Sherman WH, Nobile Orazio E, Saito T, Freddo L. Immunofluorescence studies of patients with neuropathy and IgM M-proteins. Annals of Neurology 1985; 18: 173-181. IF: 11.193 Candelise L, Landi G, Nobile-Orazio E, Boccardi E. Prognostic significance of hyperglycemia in acute stroke. Archives of Neurology 1985; 42: 661-663. IF: 7.584 Nobile-Orazio E, Spagnol G, Scarlato G. Failure to detect anti-MAG antibodies by RIA in CSF of patients with multiple sclerosis. Journal of Neuroimmunology 1986; 11:165-169. IF: 3.033 Nobile-Orazio E, Spagnol G, Daverio R, Riboni L, Macchi R, Francomano E, Scarlato G. Studies on anti-myelin antibodies in patients with multiple sclerosis. Rivista di Neurologia 1987; 57: 13-19. IF: n.n. Bresolin N, Moggio M, Bet L, Gallanti A, Prelle A, Nobile-Orazio E, Addobbati L, Ferrante C, Pellegrini G, Scarlato G. Progressive cytochrome c oxidase deficiency in a case of Kearns-Sayre Syndrome: morphological, immunological and biochemical studiesin muscle biopsies and autopsy tissues. Annals of Neurology 1987; 21: 564-572. IF: 11.193 Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, BarbieriS, Moggio M, Polli N, Polli E, Scarlato G Peripheral neuropathy in macroglobulinemia: incidence and antigen specificity of M-proteins. Neurology 1987; 37: 1506-1514. IF: 8.249 Barbieri S, Nobile-Orazio E, Baldini L, Fayoumi Z Manfredini E, Scarlato G. Visual evoked potentials in patients with neuropathy and macroglobulinemia. Annals of Neurology 1987; 22: 663-666. IF: 11.193 Landi G, D'Angelo A, Boccardi E, Candelise L, Mannucci PM, Nobile-Orazio E, Morabito A. Hypercoagulability in acute stroke: prognostic significance. Neurology 1987; 37: 1667-1671. IF: 8.249 Della Casa Alberighi O, Nobile-Orazio E, Bonara P, Hu C, Spagnol G, Radelli L, Scorza Smeraldi R. NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin associated glycoprotein (MAG). Journal of Neuroimmunology 1988; 18: 207-216. IF: 3.033 Nobile-Orazio E, Baldini L, Barbieri S, Marmiroli P, Spagnol G, Francomano E, Scarlato G. Treatment of patients with neuropathy and anti-MAG IgM M-proteins. Annals of Neurology 1988; 24: 93-97 IF: 11.193 D'Angelo A, Landi G, Vigano' D'Angelo S, Nobile Orazio E, Boccardi E, Candelise L, Mannucci PM. Protein C in acute stroke Stroke 1988; 19: 579-583. IF: 6.158 D'Angelo A, Landi G, Candelise L, Nobile Orazio E, Vigano', D'Angelo S, Mannucci PM. Significance of reduced Protein C in patients with acue stroke and unfavourable prognosis. Thrombosis and Haemostasis 1988; 60 (2): 345. IF: 6.094 Nobile-Orazio E, Francomano E, Daverio R, Barbieri S, Marmiroli P, Manfredini E, Carpo M, Moggio M, Legname G, Baldini L and Scarlato G. Anti-Myelin-Associated Glycoprotein IgM antibody titers in neuropathy associated with macroglobulinemia. Annals of Neurology 1989; 26: 543-550. IF: 11.193 Marcus DM, Latov N, Hsi BP, Gillard BK, and partecipating laboratories (Antel J, Appel S, Callegaro L, Daune G, Gillard B, Latov N, Marcus D, Nobile-Orazio E, Pestronk A, Portoukalian J, Quarles R, Salazar-Grueso E, Schneider, L, Shy M, Steck A). Eduardo Nobile-Orazio 5 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. Measurement and significance of antibodies against GM1 ganglioside. Report of a Workshop, 18/4/1989, Chicago, USA Journal of Neuroimmunology 1989; 25: 255-259. IF: 3.033 Valli G, De Vecchi A, Gaddi L, Nobile-Orazio E, Tarantino A,Barbieri S. Peripheral nervous system involvement in essential cryoglobulinemia and nephropathy. Clinical and Experimental Rheumatology 1989; 7: 479-483. IF: 2.655 Monaco S, Bonetti B, Ferrari S, Moretto G, Nardelli E, Tedesco F, Mollnes TE, Nobile-Orazio E, Manfredini E, Bonazzi L, Rizzuto N. Complement-mediated demyelination in patients with IgM monoclonal gammopathy and polyneuropathy. The New England Journal of Medicine 1990; 322: 649-652. IF: 51.658 Costa A, Baroni G, Piccolo G, Nobile-Orazio E, Lucio Liberato N, Ascari E. POEMS syndrome with IgA lambda monoclonal gammopathy. Haematologica 1990, 75: 170-172. IF: 5.935 Nobile-Orazio E, Legname G, Daverio R, Carpo M, Giuliani A, Sonnino S, Scarlato G. Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b and highmolecular-weight neural-specific glycoproteins. Annals of Neurology 1990; 28: 190-194. IF: 11.193 Nobile-Orazio E, Carpo M, Legname G, Meucci N, Sonnino S, Scarlato G. Anti-GM1 IgM antibodies in motor neuron disease and neuropathy. Neurology 1990; 40: 1747-1750. IF: 8.249 Scarlato G, Nobile-Orazio E. Motoneuron-disease-like disorder after ganglioside therapy. The Lancet 1991; 338: 314 (letter). IF: 39.060 Nobile-Orazio E, Carpo M, Scarlato G. Clinical relevance of anti-GM1 IgM antibodies. Acta Neurologica (Napoli) 1991; 13 (XLVI): 514-519. IF: n.n. Froldi M, Castagna A, Piona A, Parma M, Tedeschi A, Miadonna A, Lorini M, Nobile-Orazio E, Lazzarin A. Aumento della concentrazione liquorale di leucotriene B4 in pazienti con AIDS. Giornale di malattie infettive e parassitarie 1991; 43: 806-812. IF: n.n. Nobile-Orazio E, Barbieri S, Baldini L, Marmiroli P, Carpo M, Premoselli S, Manfredini E, Scarlato G. Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies. Acta Neurologica Scandinavica 1992; 85: 383-390. IF: 2.474 Nobile-Orazio E, Carpo M, Meucci N, Grassi MP, Capitani E, Sciacco M, Mangoni A, Scarlato G. Guillain Barre' Syndrome associated with high titers of anti-GM1 antibodies. Journal of the Neurological Sciences 1992; 109: 200-206. IF: 2.243 Froldi M, Castagna A, Parma M, Piona A, Tedeschi A, Miadonna A, Lorini M, Nobile-Orazio E, Lazzarin A. Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement. Journal of Neuroimmunology 1992; 38: 155-162. IF: 3.033 Landi G, D'Angelo A, Boccardi E, Candelise L, Mannucci PM, Morabito A, Nobile-Orazio E. Venous thromboembolism in acute stroke: prognostic importance of hypercoagulability. Archives of Neurology 1992; 49: 279-283. IF: 7.584 Nobile-Orazio E, Meucci N, Barbieri S, Carpo M, Scarlato G. High-dose intravenous immunoglobulin in multifocal motor neuropathy. Neurology 1993: 43: 537-544. IF: 8.249 Nobile-Orazio E, Meucci N, Barbieri S, Carpo M, Scarlato G. Immunoglobulin therapy. Neurology 1993; 43: 2727-8 (letter, reply). IF: 8.249 Heiman-Petterson T, Krupa T, Thompson P, Nobile-Orazio E, Tahmoush AJ, Shy ME. Anti-GM1/GD1b M-proteins damage human spinal cord neurons cocultured with muscle. Eduardo Nobile-Orazio 6 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. Journal of the Neurological Sciences 1993; 120: 38-45. IF: 2.243 Baldini L, Nobile-Orazio E, Guffanti A, Barbieri S, Carpo M, Cro L, Cesana B, Damilano I, Maiolo AT. Peripheral neuropathy in IgM monoclonal gammopathy and Waldenstrom macroglobulinemia: a frequent complication in elderly males with low MAG-reactive serum monoclonal component. American Journal of Hematology 1994; 45: 25-31. IF: 4.003 Nobile-Orazio E, Carpo M, Scarlato G. Gangliosides: their role in clinical neurology Drugs 1994; 47: 576-585. IF: 4.633 Nobile-Orazio E, Manfredini E, Sgarzi M, Spagnol G, Allaria S, Quadroni M, Scarlato G. Serum IgG antibodies to a 35kDa P0-related glycoprotein in motor neuron disease. Journal of Neuroimmunology 1994, 53: 143-151. IF: 3.033 Nobile-Orazio E, Manfredini E, Carpo M, Meucci N, Monaco S, Ferrari S, Bonetti B, Cavaletti G, Gemignani F, Durelli L, Barbieri S, Allaria S, Sgarzi M, Scarlato G. Frequency and clinical correlates of anti-neural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy. Annals of Neurology 1994; 36: 416-424. IF: 11.193 Froldi M, Parma M, Marenzi R, Piona A, Lorini M, Nobile-Orazio E, Castagna A, Lazzarin A. Low levels of LTB4 in cerebrospinal fluid of AIDS patients with cryptococcal meningitis. Journal of Clinical Laboratory Immunology 1995; 47 (1): 41-7. IF: n.n. Monaco S, Ferrari S, Bonetti B, Moretto G, Kirshfink M, Nardelli E, Nobile-Orazio E, Zanusso G, Rizzuto N, Tedesco F. Experimental induction of myelin changes by anti-MAG antibodies and terminal complement complex. Journal of Neuropathology and Experimental Neurology 1995: 54:96-104. IF: 4.345 Barbieri S, Sandroni P, Nobile-Orazio E, Cappellari A, Cavestro C, Baldini L, Scarlato G. Small fiber involvement in neuropathy associated with IgG, IgA and IgM monoclonal gammopathy. Electromyography and Clinical Neurophysiology (ora Clinical Neurophysiology) 1995; 35: 39-44. IF: 3.144. Ogino M, Nobile-Orazio (E), Latov N. IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1 and IgG3 subclasses Journal of Neuroimmunology 1995; 58: 77-80. IF: 3.033 Manfredini E, Nobile-Orazio E, Allaria S, Scarlato G. Anti-alpha- and beta-tubulin IgM antibodies in dysimmune neuropathies. Journal of the Neurological Sciences 1995; 133: 79-84. IF: 2.243 Carpo M, Nobile-Orazio E, Chigorno V, Sonnino S. The anti-oligosaccharide antibodies present in sera from patients with motor neuron disease and neuropathy recognize the N-glycolylneuraminic acid containing epitope. Glycoconjugate Journal 1995; 12: 729-731. IF: 1.882 Meucci N, Nobile-Orazio E, Scarlato G. Intravenous immunoglobulin therapy in amyotrophic lateral sclerosis. Journal of Neurology 1996; 243: 117-120. IF: 3.578 van den Berg L, Hays AP, Nobile-Orazio E, Kinsella LJ, Manfredni E,Corbo M, Rosoklija G, Younger DS, Lovelace RE, Trojaburg W, Lange DE, Goldstein S, Delfiner JS, Sadiq S, Sherman WH, Latov N. Anti-MAG and anti-SGPG antibodies in neuropathy. Muscle and Nerve 1996; 19: 637-643. IF: 2.314 Cappellari A, Nobile-Orazio E, Meucci N, Scarlato G, Barbieri S. Multifocal motor neuropathy: a possible source of error in the serial evaluation of conduction block. Muscle and Nerve 1996; 19: 666-669. IF: 2.314 Carpo M, Nobile-Orazio E, Meucci N, Gamba M, Barbieri S, Allaria S, Scarlato G. Anti-GD1a ganglioside antibodies in peripheral motor syndromes. Annals of Neurology 1996; 39: 539-543. IF: 11.193 Gemignani F, Marchesi G, Di Giovanni G, Salih S, Quaini F, Nobile-Orazio E. Eduardo Nobile-Orazio 7 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. Low-grade non-Hodgkin B-cell lymphoma presenting as sensory neuropathy. European Neurology 1996; 36: 138-141. IF: 1.811 Nobile-Orazio E. Multifocal motor neuropathy (Editorial) Journal of Neurology, Neurosurgery and Psychiatry 1996; 60: 599-603. IF: 4.924 Cappellari A, Nobile-Orazio E, Meucci N, Scarlato G, Barbieri S,. Criteria for the early detection of conduction block in multifocal motor neuropathy (MMN): a study based on control populations and follow-up of MMN patients. Journal of Neurology 1997; 244: 625-630. IF: 3.578 Meucci N, Cappellari A , Barbieri S, Scarlato G, Nobile-Orazio E. Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor neuropathy. Journal of Neurology, Neurosurgery and Psychiatry 1997; 63: 765-769. IF: 4.924 Carpo M, Pedotti R, Lolli F. Pitrola A. Allaria S, Scarlato G, Nobile-Orazio E. Clinical correlate and fine specificity of anti-GQ1b antibodies in peripheral neuropathy. Journal of Neurological Sciences 1998; 155: 186-191. IF: 2.243 Spagnol G, Doneda P, Cavanna B, Sgarzi M, Manfredini E, Allaria S, Scarlato G, Nobile-Orazio E. Expression of glycosylated recombinant human myelin-associated glycoprotein (MAG) on a neuroblastoma cell line and its reactivity with HNK-1 but not human anti-MAG antibodies. Neuroscience Letters 1998; 246(3): 157-160. IF: 2.026 Carpo M, Cappellari A, Mora G, Pedotti R, Barbieri S, Scarlato G, Nobile-Orazio E. Deterioration of multifocal motor neuropathy after plasma exchange. Neurology 1998; 50:1480-1482. IF: 8.249 Borasio GD, Robberecht W, Leigh PN, Emile J, Guiloff RJ, Jerusalem F, Silani V, Vos PE, Wokke JHJ, Dobbins T, and the European ALS/IGF-1 Study Group (tra cui E. Nobile-Orazio, vedi appedice) A placebo-controlled trial of insuline-like growth factor-I in amyotrophic lateral sclerosis. Neurology 1998; 51: 583-586. IF: 8.249 Pedotti R, Carpo M, Lucchi S, Righini A, Scarlato G, Nobile-Orazio E. Lumbosacral root and facial nerve enhancement in Miller Fisher syndrome. Journal of Neurology 1998; 245: 753-754. IF: 3.578 Nobile-Orazio E, Carpo M Rilevanza diagnostica degli anticorpi antinervo nelle neuropatie disimmuni Italian Journal of Neurological Sciences 1998; 19 (suppl): S136-S140. IF: 1.412 Ferrari S, Morbin M, Nobile-Orazio E, Musso A, Tomelleri G, Bertolasi L, Rizzuto N, Monaco S. Anti-sulfatide neuropathy: antibody mediated complement attack to peripheral myelin. Acta Neuropathologica 1998; 96: 569-574. IF: 9.734 Maccario M, Tarantino A, Nobile-Orazio E, Ponticelli C. Campylobacter jejuni bacteremia and Guillain Barré syndrome in a renal transplant recipient. Transplant International 1998; 11: 439-442. IF: 3.155 Meola G, Sansone V, Rotondo G, Nobile-Orazio E, Mongini T, Angelini C, Toscano A, Mancuso M, Siciliano G. PROMM in Italy: Clinical and Biomolecular findings. Acta Myologica 1998; Vol. II: 21-26. IF: n.n. Cavanna B, Carpo M, Pedotti R, Meucci N, Allaria S , Scarpini E, Scarlato G, Nobile-Orazio E. Anti-GM2 IgM antibodies: clinical correlates and reactivity with a human neuroblastoma cell line. Journal of Neuroimmunology 1999; 94: 157-164. IF: 3.033 Di Troia A, Carpo M, Meucci N, Pellegrino C, Allaria S, Gemignani F, Marbini A, Mantegazza R, Sciolla R, Manfredini E, Scarlato G, Nobile-Orazio E. Clinical features and anti-neural reactivity in neuropathy associated with IgG monoclonal gammopathy of undetermined significance Journal of the Neurological Sciences 1999; 164: 64-71. IF: 2.243 Meucci N, Baldini L, Cappelari A, Di Troia A, Allaria S, Scarlato G, Nobile-Orazio E. Anti-MAG antibodies predict the development of neuropathy in asymptomatic patients with IgM monoclonal gammopathy. Annals of Neurology 1999; 46: 119-122. IF: 11.193 Eduardo Nobile-Orazio 8 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. Carpo M., Pedotti R, Allaria S, Lolli F, Matà S, Cavaletti G, Protti A, Pomati S, Scarlato G, NobileOrazio E. Clinical presentation and outcome of Guillain-Barré and related syndromes in relation to antiganglioside antibodies Journal of the Neurological Sciences 1999, 168: 78-84. IF: 2.243 Carpo M, Allaria S, Scarlato G, Nobile-Orazio E. Marginally improved detection of GM1 antibodies by covalink ELISA in multifocal motor neuropathy. Neurology 1999; 53 2206-7. IF: 8.249 Comment in: Nobile-Orazio E, Carpo M, Scarlato G. Testing for serum IgM binding to GM1 in clinical practice. Neurology 2000; 54: 2353 (letter, reply). IF: 8.249 Nobile-Orazio E, Carpo M, Allaria S, Gamba M. Diagnostic relevance of anti-neural antibodies in dysimmune neuropathies. Electroencephalography and Clinical Neurophysiology 1999 (ora Clinical Neurophysiology); Supplement 50 (Clinical Neurophysiology: from receptor to perception. G. Comi, CH Lucking, J Kimura, PM Rossini, eds.): 419-427. IF: 3.144 Nobile-Orazio E, Meucci N. High-dose intravenous immuno-globulins in multifocal motor neuropathy. Electroencephalography and Clinical Neurophysiology 1999 (ora Clinical Neurophysiology); Supplement 50 (Clinical Neurophysiology: from receptor to perception. G. Comi, CH Lucking, J Kimura, PM Rossini, eds.): 506-513. IF: 3.144 Merkies ISJ, Schmitz PIM, Samijn JPA, van der Meche FGA, van Doorn PA, for the European Inflammatory Neuropathy Cause andTreatment (INCAT) Group (Aubry J, Baumann N, Bouche P, Comi G, Dalakas MC, Hartung HP, Hughes RAC; Illa I, Knapp MRJ, Léger J-M, Nemni R, NobileOrazio E, Toyka KV, van de Bergh P, van der Meché FGA, van Doorn PA, Willison HJ, YounesChennoufi B) Fatigue in immune-mediated polyneuropathies Neurology 1999; 53; 1648-1654. IF: 8.249 Merkies ISJ, Schmitz PIM, van der Meché FGA, van Doorn, PA for the Inflammatory Neuropathy Cause and Treatment (INCAT) Group (Aubry J, Baumann N, Bouche P, Comi G, Dalakas MC, Hartung HP, Hughes RAC; Illa I, Knapp MRJ, Léger J-M, Nemni R, Nobile-Orazio E, Toyka KV, van de Bergh P, van der Meché FGA, van Doorn PA, Willison HJ, Younes-Chennoufi B) Psychometric evaluation of a new sensory scale in immune-mediated polyneuropathies Neurology Neurology 2000; 54:943-949 IF: 8.249 Nobile-Orazio E, Meucci N, Baldini L, Di Troia A, Scarlato G. Long-term prognosis of neuropathy associated with anti-MAG IgM M-proteins and its relation with immune therapies. Brain 2000; 123: 710-717. IF: 9.915 Odaka M, Yuki N, Nobile-Orazio E, Carpo M, Hiraka K. Antibodies to GM1(NeuGc) in Guillain Barré syndrome after ganglioside therapy. Journal of the Neurological Sciences 2000; 175: 96-106. IF: 2.243 Carpo M, Meucci N, Allaria S, Marmiroli P, Monaco S, Toscano A, Simonetti S, Scarlato G, Nobile-Orazio E. Anti-sulfatide IgM antibodies in peripheral neuropathy. Journal of the Neurological Sciences 2000; 176: 144-150. IF: 2.243 Prelle A, Sciacco M, Comi GP, Messina S, Carpo M, Ciscato P, Nobile-Orazio E, Fortunato F, Mora G, Bignotti V, Fagiolari G, Moggio M, Scarlato G. A sporadic, atypical case of desminopathy: morphological and immunological characterization. Clinical Neuropathology 2000; 19: 208-212. IF: 1.379 Guillain-Barré Syndrome Study group (Nappi G, Scarlato G, Citterio A, Molinari S, Cosi V, Piccolo G, Bono G, Faggi L, Mariani G, Nobile Orazio E, Matozzo F, Vitelli E, Carpo M, Pellegrino C, Bersano A, Antozzi C, Pinardi G, Protti A, Marazzi R, Gambaro P, Vecchio C, Poloni M, Albizzati AM, De Simone V, Bordo B, Mattioli M, Ciani M, Perrone P, Marsile C, Bascelli C, Beghi E, Eduardo Nobile-Orazio 9 80. 81. 82. 83. 84. 85. 86. 87. 88. Bogliun G, Rotondo G, Crespi V, Marmiroli P, Magrotti E, Delodovici ML, La Spina I, Frazzitta G, Perini M, Bassi P, Gomitoni A) The Guillain-Barré syndrome: an Italian multicenter case-control study. Neurological Sciences 2000; 21: 229-234 IF: 1.412 Buchwald B, Bufler J, Carpo M, Heidenreich F, Pitz R, Dudel J, Nobile-Orazio E, Toyka KV. Combined pre- and postsynaptic action of IgG antibodies in Miller Fisher syndrome. Neurology 2001; 56: 67-74. IF: 8.249 Cavanna B, Jiang H, Allaria S, Carpo M, Scarlato G, Nobile-Orazio E. Anti-GM2 IgM antibody-induced complement-mediated cytotoxicity in patients with dysimmune neuropathies. Journal of Neuroimmunology 2001; 114: 226-231. IF: 3.033 Nobile-Orazio E. Multifocal motor neuropathy. (Review Article) Journal of Neuroimmunology 2001; 115: 4-18 IF: 3.033 Nobile-Orazio E, Carpo M, Meucci N. Are there immunologically treatable motor neuron diseases? Amyotrophic lateral sclerosis and other motor neuron disorders 2001;2(suppl 1):S23-30. IF: 2.369 European workshop on multifocal neuropathy (Buchwald B, Franssen H, Hughes RAC, Léger J-M, Leigh N, Mills KR, Nobile-Orazio E, Pouget J, Toyka KV, Van den Berg LH, Van den Bergh P, Van Doorn PA, Plomp JJ, Visser MC, Willison HJ, Wokke JHJ) 79th ENMC interantional workshop: Multifocal motor neuropathy (Workshop report). Neuromuscular Disorders 2001; 11: 309-314. IF:3.464 Hughes RAC, Bensa S, Willison HJ, van den Bergh P, Comi G, Illa I, Nobile-Orazio E, van Doorn P, Dalakas M, Bojar M, Swan A and the Inflammatory Neuropathy Cause and Treatment (IINCAT) group. Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy Annals of Neurology 2001; 50: 195-201. IF: 11.193 Nobile-Orazio E, Carpo M. Neuropathy and monoclonal gammopathy. Current Opinion in Neurology 2001; 14: 615-620. IF: 5.416 Nobile-Orazio E, Meucci N, Carpo M, Terenghi, Bersano A, Cappellari A, Barbieri S, Scarlato G. Multifocal motor neuropathy: clinical and immunological features and response to IVIg in relation to the presence and degree of motor conduction block. Journal of Neurology, Neurosurgery and Psychiatry 2002; 72:761-6. IF: 4.924 Terenghi F, Allaria S, Scarlato G, Nobile-Orazio E. Multifocal motor neuropathy and Campylobacter jejuni reactivity. Neurology 2002; 59: 282-284 89. IF: 8.249 Toscano A, Rodolico C, benvenga S, Girlanda P, Laurà M, Mazzeo A, Nobile-Orazio E, Trimarchi F, Vita G, Messina C. 90. 91. 92. Multifocal motor neuropathy and asymptomatic Hashimotos’s thyroiditis: first report of an association. Neuromuscular disorders 2002; 12: 566-568. IF: 3.464 Nobile-Orazio E, Bersano A. High-dose intravenous immunoglobulin therapy in dysimmune neuropathies Neurological Sciences 2002; 23 (Suppl 1): S25-S32 IF: 1.412 Umapathi T, Hughes RAC, Nobile-Orazio E, Leger JM Immunosuppressive tratment for multifocal motor neuropathy. Cochrane Database of Systematic Reviews 2002; Issue 3. Oxford:Update Software IF: 5.703. Nobile-Orazio E, Casellato C, Di Troia A. Neuropathies associated with IgG and IgA monoclonal gammopathy. Revue Neurologique (Paris) 2002; 158: 979-987 IF: 0.499 Eduardo Nobile-Orazio 10 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. Comi G, Roveri L, Swan A, Willison H, Bojar M, Illa I, Karageorgiou C, Nobile-Orazio E, van den Bergh P, Swan T, Hughes RAC and the Inflammatory Neuropathy Cause and Treatment (INCAT) group. A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy. Journal of Neurology 2002; 249: 1370-1377 IF: 3.578 Priori A, Cinnante C, Pesenti A, Carpo M, Cappellari A, Nobile-Orazio E, Scarlato G, Barbieri S Distinctive abnormalities of motor axonal strength-duration properties in multifocal motor neuropathy and in motor neuron disease Brain 2002;125: 2481-90 IF: 9.915 Lunn M., Nobile-Orazio E. Immunnotherapy for IgM anti-Myelin-associated Gglycoprotein paraprotein associated neuropathy. The Cochrane Database of Systematic Reviews 2003; Issue 1. Oxford :Update Software IF: 5.703 Micco A, Nobile-Orazio E, Baron P, Conti G, Napoli L, Serafini M, Scarlato G, Scarpini E. Severe chronic sensory-motor polyneuropathy: coexistence of 3 unrelated etiologies in a type 1 diabetic patient. A case report and review of the literature Journal of the Peripheral Nervous System 2003; 8: 23-28 IF: 2.570 De Giorgio R, Bovara M, Barbara G, Canossa M, Sarnelli G, De Ponti F, Stanghellini V, Tonini M, Cappello S, Pagnotta E, Nobile-Orazio E, Corinaldesi R. Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotility. Gastroenterology. 2003 Jul;125(1):70-9. IF: 12.821 McCrone P, Chisholm D, Knapp M, Hughes R, Comi G, Dalakas M, Illa I, Kilindireas C, NobileOrazio E, Swan A, Van den Bergh P, Willison HJ, the INCAT Study Group Cost-Utility Analysis of Intravenous Immunoglobulin and Prednisolone for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) European Journal of Neurology 2003; 10: 687-694 IF: 4.162 Nobile-Orazio E, Terenghi F, Carpo M, Bersano A. Treatment of multifocal motor neuropathy Neurological Sciences 2003; 24 (Suppl 4): S251-S255 IF: 1.412 Nobile-Orazio E, Terenghi F Other Dysimmune neuropathies. In : Peripheral Neurologic Disease Continuum, Lifelong Learning in Neurology. December 2003; Volume 9, No. 6: 56-85 IF: n.n. Terenghi F, Cappellari A, Versano A, Carpo M, Barbieri S, Nobile-Orazio E How-long is IVIg effective in multifocal motor neuropathy? Neurology 2004; 62:666-8. IF: 8.249 Bersano A, Carpo M, Cappellari A, Bresolin N, Nobile-Orazio E Transient response to immune therapies in post-irradiation lumbosacral radiculoplexopathy. Journal of Neurology 2004; 251; 488-490 IF: 3.578 Nobile-Orazio E IgM paraproteinaemic neuropathies. Current Opinion in Neurology 2004; 17(5): 599-605 IF: 5.416 Nobile-Orazio E. Neuropathy and monoclonal gammopathy Haematologica 2004; 89 (Suppl. 1) : 23-29. IF: 5.935 Basilisco G, Gebbia C, Peracchi M, Velio P, Conte D, Bresolin N, Nobile-Orazio E. Cerebellar degeneration and hearing loss in a patient with idiopathic myenteric ganglionitis. European Journal Gastroenterology and Hepatology. 2005 Apr;17(4):449-52. IF: 1.915 Padua L, Schenone A, Aprile I, Benedetti L, Calandro P, Tonali P, Nobile-Orazio E for the Italian NEUROPA Study Group Qualità of life and disability assessment in neuropathy: a multicenter study. Journal of the Peripheral Nervous System 2005; 10: 3-10 IF: 2.570 Nobile-Orazio E Treatment of Dysimmune Neuropathies. ENS Teaching Review Journal of Neurology 2005; 252 (4): 385-95. IF: 3.578 Nobile-Orazio E, Cappellari A, Priori A. Eduardo Nobile-Orazio 11 109. 110 111. 112. 113. 114. 115. 116. 117. 118. Multifocal Motor Neuropathy: current concepts and controversies Muscle and Nerve 2005; 31: 663 - 680 IF: 2.314 Hughes R on behalf of the CIDPand MMN trial group (Blomkwist P, Hughes R, Illa I, Léger J-M, McCrone P, Murphy C, Nobile-Orazio E, Swan A, van den Berg L, van den Bergh P, van Doorn P, van Schaik I) 129th ENMC International Workshop: Clinical Trials for Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy, 27th October 2004, Schiphol Airport, The Netherlands. Neuromuscular Disorders 2005;15: 321-5. IF: 3.464 Nobile-Orazio E, Terenghi F. IVIg in idiopathic autoimmune neuropathies: analysis in the light of the latest results Journal of Neurology 2005; 252 (Suppl 1): 1/7-1/13 IF: 3.578 Priori A, Bossi B, Ardolino G, Bertolasi L, Carpo M, Nobile-Orazio E, Barbieri S. Pathophysiological heterogeneity of conduction blocks in multifocal motor neuropathy. Brain. 2005; 128:1642-8. IF: 9.915 Scarlato M, Previtali SC, Carpo M, Pareyson D, Briani C, Del Bo R, Nobile-Orazio E, Quattrini A, Comi GP Polyneuropathy in POEMS syndrome: role of angiogenic factors in the pathogenesis. Brain. 2005; 28:1911-20. IF: 9.915 Umapathi T, Hughes R, Nobile-Orazio E, Leger J Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. Cochrane Database of Systematic Reviews 2005 Jul 20 (3): IF: 5.703. Joint Task Force of the EFNS and the PNS (Hughes RAC, Bouche P, Cornblath DR, Evers E, Hadden RD, Hahn AF, Illa I, Koski CL, Léger J-M, Nobile-Orazio E, Pollard JD, Sommer C, Van den Bergh P, van Doorn PA, van Schaik I) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society Journal of the Peripheral Nervous System 2005; 10: 220-228 IF: 2.570 Franciotta D, Avolio C, Capello E, Lolli F, AINI participating members (Trojano M, Leante R, Falcone M, Marrosu M, Costa G, Murru MR, Cocco E, Galli E, Chicchi A, Maimone D, Cuccia S, Lugaresi A, Pantalone A, Paolino E, Castellazzi M, Zaffaroni M, Villa C, Giunti D, Panarese C, Ribizzi G, Vita G, Aguennouz M, Ciranni AM, Salmaggi A, Bernardi G, Ciusani E, Passerini G, Nobile-Orazio E, Carpo M, Allaria S, Merelli E, Bedin R, Bertolotto A, Sala A, Gallo P, Zardini E, Andreoni L, Siciliano G, Bacci A, Meucci G, Simone P, Desina G, Di Viesti P, Apollo F, Sotgiu S, Deiana G, Annunziata P, Morucci A, Bonetti B, Alberti D. Consensus recommendations of the Italian Association for Neuroimmunology for immunochemical cerebrospinal fluid examination. Journal of the Neurological Sciences, 2005; 237: 5–11 IF: 2.243 Bersano A, Carpo A, Allaria A, Franciotta D, Citterio A, Nobile-Orazio E Long term disability and social status change after Guillain-Barré syndrome Journal of Neurology 2006; 253: 214-218 IF: 3.578 Joint Task Force of the EFNS and the PNS (Hughes RAC, Bouche P, Cornblath DR, Evers E, Hadden RD, Hahn AF, Illa I, Koski CL, Léger J-M, Nobile-Orazio E, Pollard JD, Sommer C, Van den Bergh P, van Doorn PA, van Schaik I) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of multifocal motor neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society Journal of the Peripheral Nervous System 2006; 11: 1-8 IF: 2.570 Joint Task Force of the EFNS and the PNS (Hadden RD, Nobile-Orazio E, Sommer C, Hahn AF, Illa I, Morra E, Pollard JD, Hughes RAC, Bouche P, Cornblath DR, Evers E, Koski CL, Léger J-M, Van den Bergh P, van Doorn PA, van Schaik I) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society Eduardo Nobile-Orazio 12 Journal of the Peripheral Nervous System 2006; 11: 9-19 IF: 2.570 119. Terenghi F, Allaria S, Nobile-Orazio E Circulating levels of cytokines and their modulation by IVIg in multifocal motor neuropathy Journal of the Peripheral Nervous System 2006; 11: 67-71 IF: 2.570 120. Hughes RAC, Bouche P, Cornblath DR, Evers E, Hadden RD, Hahn AF, Illa I, Koski CL, Léger JM, Nobile-Orazio E, Pollard JD, Sommer C, Van den Bergh P, van Doorn PA, van Schaik I Response to comment on European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy. Journal of the Peripheral Nervous System 2006; 11: 90-91 (letter, reply) IF: 2.570 121. Lunn MPT, Nobile-Orazio E Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies [Review] Cochrane Database Systematic Reviews 2006; (2) IF: 5.703 122. Hughes RA, Bouche P, Cornblath DR, Evers E, Hadden RD, Hahn A, Illa I, Koski CL Leger JM, Nobile-Orazio E, Pollard J, Sommer C, Van den Bergh P, van Doorn PA, van Schaik IN. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. European Journal of Neurology 2006; 13: 326-332. IF: 4.162 123. van Schaik IN, Bouche P, Illa I, Leger JM, Van den Bergh P, Cornblath DR, Evers E, Hadden RD, Hughes RA, Koski CL, Nobile-Orazio E, Pollard J, Somner C, van Doorn PA, European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. European Journal of Neurology 2006;13: 802-8. IF: 4.162 124. Hadden RD, Nobile-Orazio E, Hahn A, Illa I, Morra E, Pollard J, Hughes RA, Bouche P, Cornblath DR, Evers E, , Koski CL, Leger JM, , Van den Bergh P, van Doorn PA, van Schaik IN. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. European Journal of Neurology 2006; 13: 809-18. IF: 4.162 125. Bersano A, Fiorini M, Allaria S, Zanusso G, Fasoli E, Gelati M, Monaco H, Squintani G, Monaco S, Nobile-Orazio E. Detection of CSF 14-3-3 protein in Guillain Barré syndrome Neurology 2006; 67: 2211-2216 IF: 8.249 126. Allen D, Lunn MPT, Niermeijer J, Nobile-Orazio E, Treatment for IgG and IgA paraproteinemic neuropathy. Cochrane Database of Systematic Reviews 2007, Issue 1, Art. No. CD005376 IF: 5.703 127. Ardolino G, Bossi B, Barbierib B, Nobile-Orazio E, Priori A. Pathophysiology of conduction block in multifocalmotor neuropathy Schweizer Archive fur Neurologie und Psychiatrie 2007;158:78–80. IF: n.n. 128. Benedetti L, Briani C, Grandis M, Vigo T, Gobbi M, Ghiglione E, Carpo M, Cocito D, Caporale C, Soriani MP, Mancardi GL, Nobile-Orazio E, Schenone A. Predictors of response to Rituximab in patients with neuropathy and anti-myelin associated glycoprotein immunoglobulin M. Journal of the Peripheral Nervous System 2007; 12: 102-107 IF: 2.570 129. Terenghi F, Ardolino GL, Nobile-Orazio E. Guillain-Barré syndrome after combined CHOP and rituximab therapy in non-hodgkin lymphoma. Journal of the Peripheral Nervous System 2007; 12: 142-143 IF: 2.570 130. Cavaletti G, Nobile-Orazio E, Bortezomib-induced peripheral neurotoxicity: still far from a painless gain. Haematologica 2007; 92: 1308-9 (editorial) IF: 5.935 131. Nobile-Orazio E, Gallia F, Terenghi F, Allaria S, Giannotta C, Carpo M How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies? Journal of the Neurological Sciences. 2008; 266:156-63 IF: 2.243 Eduardo Nobile-Orazio 13 132. Ardolino G, D’Adda E, Nobile-Orazio E Recurrent atrial fibrillation after subcutaneous apomorphine. Parkinsonism & Related Disorders 2008;14:173-4; IF: 3.274 133. Nobile-Orazio E, Evidence for long-term IVIg treatment of chronic inflammatory demyelinating polyradiculoneuropathy. Nature Clinical Practice Neurology 2008; 4: 352-353 IF: 15.518 134. Benedetti L, Briani C, Franciotta D, Carpo M, Padua L, Zara G, Zambello R, Sormani MP, Mancardi GL, Nobile-Orazio E, Schenone A Long-term effect of Rituximab in anti-MAG polyneuropathy Neurology 2008; 71: 1742-1744 IF: 8.249 135. van Nes I, Faber CG, Hamers RM,Harschnitz O, Bakkers M, Hermans MC, Meijer RJ, van Doorn PA, Merkies IS and the Perinoms Study Group (Bennett D, van den Berg LH, Van den Bergh PY, Cornblath DR, DalakaS M, van Doorn PA, Faber CG, Gorson KC, Hadden RD, Hahn AF, Hughes RA, Lauria G, Léger JM, Lewis RA, Lunn PT, Merkies IS, Nobile-Orazio E, Notermans NC, Padua L, Reilly MM) Revising two-point discrimination assessment in normal aging and in patients with polyneuropathies Journal of Neurology Neurosurgery & Psychiatry 2008 Jul;79(7):832-4. IF: 4.924 136. Nobile-Orazio E What is new in multifocal motor neuropathy in 2007-2008 Journal of the Peripheral Nervous System 2008; 13: 261-263 IF: 2.570 137. Umapathi T, Hughes R, Nobile-Orazio E, Leger J Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. Cochrane Database Systematic Reviews 2009 Jan 21;(1):CD003217 IF: 5.703 138. Galassi G, Girolami F, Nobile-Orazio E, Funakoshi K, Ariatti A, Odaka M Acute hand weakness as a regional variant of Guillain-Barré syndrome European Journal of Neurology 2009; 16: e49 (letter) IF: 4.162 139. RMC Trial Group (Mahdi-Rogers M, Rutterford C, Hughes RA, Léger JM, Nobile-Orazio E, Van den Bergh P, van Doorn P, van Schaik IN, Hadden RD, Choy E, Reilly M, Winer J, Evers E, Créange A, Gueguen A, Uzenot D, Behin A, Nicolas G, Pautot V, Uncini A, Manzoli C, Lauria G, Pareyson D, Casellato C, Sabatelli M, Conte A, Luigetti M, Briani C, Lucchetta M, Schenone A, Benedetti L, Fiorina E, Brusse E, van der Kooi AJ, Guiloff RJ, Rakowicz WP, Lecky BR, Dougan CF, Marshall D, Davies N, Busby M, Lansbury A, Overell J, Willison HJ, Rajabally YA, Kendall B, Gow D, Nixon J, Kulkarni O, Katifi H, Hammans S, Gibson A, McDermott C, Cornblath DR, Chaudry V) Pilot Randomised Controlled Trial of Methotrexate for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (RMC Trial) Lancet Neurology 2009; 8: 158-164 IF: 23.917 140. Padua L, Briani C, Jann S, Nobile-Orazio E., Pazzaglia C, Morini A, Mondelli M, Ciaramitaro P, Cavaletti G, Cocito D, Fazio R , Santoro L, Galeotti F, Carpo M, Plasmati R, Benedetti L, Schenone A, Marchettini P, Cruccu G. Validation of the Italian version of the Neuropathic Pain Symptom Inventory (NPSI) in peripheral nervous system diseases. Neurological Sciences 2009; 30: 99-106 IF: 1.412 141. Nobile-Orazio E, Terenghi F, Giannotta C, Gallia F, Nozza A. Serum VEGF levels in POEMS syndrome and in immune-mediated neuropathies. Neurology 2009; 72(11): 1024-6. IF: 8.249 142. Nobile-Orazio E. Antigenic determinants in IgM parapotein-related neuropathies. Clinical Lymphoma & Myeloma (già Clinical Lymphoma) 2009 Feb; 9(1):107-9. IF: 1.667 143. The CI-PERINOMS study Group (including Nobile-Orazio E.) Announcement: CI-PERINOMS: chemotherapy-induced peripheral neuropathy outcome measures study Journal of the Peripheral Nervous System 2009; 14: 69-71 IF: 2.570 144. Nobile-Orazio E, Terenghi F, Cocito D, Gallia F, Casellato C. Eduardo Nobile-Orazio 14 145. 146. 147. 148. 149. 150. 151. 152. 153. Oral methotrexate as adjunctive therapy in patients with Multifocal Motor Neuropathy on chronic IVIg therapy. Journal of the Peripheral Nervous System 2009; 14: 203-205 IF: 2.570 van Nes SI, Vanhoutte EK, Faber CG, Garssen M, van Doorn PA, Merkies IS and the PeriNomS Study Group (Bennett D, van den Berg LH, Van den Bergh PY, Cornblath DR, Dalakas M, Devigili G, van Doorn PA, Faber CG, Gorson KC, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Lauria G, Léger JM, Lewis RA, Lunn MP, Merkies IS, Nobile-Orazio E, Notermans NC, Padua L, Reilly MM, Smith B). Improving fatigue assessment in immune-mediated neuropathies: the modified Rasch-built fatigue severity scale. Journal of the Peripheral Nervous System 2009; 14: 268-78. IF: 2.570 Cocito D, Paolasso I, Antonini G, Benedetti L, Briani C, Comi C, Fazio R, Jann S, Matà S, Mazzeo A, Sabatelli M, Nobile-OrazioE. A nationwide retrospective analysis on the effect of immune therapies in patients with Chronic Inflammatory Demyelinating Polyneuropathy. European Journal of Neurology 2010; 17: 289-294 IF: 4.162 Nobile-Orazio E, Giannotta C, Briani C Anti-ganglioside complex IgM antibodies in multifocal motor neuropathy and chronic immunemediated neuropathies Journal of Neuroimmunology 2010; 219: 119-122 IF: 3.033 Van den Bergh PYK , Hadden RDM , Bouche P , Cornblath DR , Hahn A , Illa I, Koski CL, Léger J-M , Nobile-Orazio E , Pollard J , Sommer C , van Doorn PA, van Schaik IN. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society — First Revision European Journal of Neurology 2010; 17: 356-363 IF: 4.162 Joint Task Force of the EFNS and the PNS (Van den Bergh PY, Hadden RD, Bouche P, Cornblath DR, Hahn A, Illa I, Koski CL, Léger JM, Nobile-Orazio E, Pollard J, Sommer C, van Doorn PA, van Schaik IN) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society – First Revision Journal of the Peripheral Nervous System 2010; 15: 1-9 IF: 2.570 Nobile-Orazio E, Gallia F, Tuccillo F, Terenghi F Chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy: treatment update. Current Opinion in Neurology 2010 23(5):519-23 IF: 5.416 Joint Task Force of the EFNS and the PNS (Hadden RD, Nobile-Orazio E, Sommer CL, Hahn AF, Illa I, Morra E, Pollard JD, Lunn MP, Bouche P, Cornblath DR, Evers E, Koski CL, Léger JM, Van den Bergh P, van Doorn PA, van Schaik IN) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathy: Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society – First Revision Journal of the Peripheral Nervous System 2010; 15: 185-195 IF: 2.570 Joint Task Force of the EFNS and the PNS (van Schaik IN, Léger JM, Nobile-Orazio E, Cornblath DR, Hadden RD, Koski CL, Pollard JD, Sommer C, Illa I, van den Bergh P, van Doorn PA.) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of multifocal motor neuropathy: Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society – First Revision Journal of the Peripheral Nervous System 2010; 15: 295-301 IF: 2.570 Nobile-Orazio E Update on neuropathies associated with monoclonal gammopathy of undetermined significance (2008–2010) Eduardo Nobile-Orazio 15 Journal of the Peripheral Nervous System 2010; 15: 301-306 IF: 2.570 154. Pazzaglia C, Briani C, Nobile-Orazio E,Caliandro P, Granata G, Tonali P, Padua L. Occurrence and characterisation of Pain in dysimmune neuropathies: a multicentre prospective study. European Journal of Neurology 2011, 18: 177–183 IF: 4.162 155. Riva N, Iannaccone S, Corbo M, Casellato C, Sferrazza B, Lazzerini A, Scarlato M, Cerri F, Previtali SC, Nobile-Orazio E, Comi G, Quattrini A Motor Nerve Biopsy: Clinical Usefulness and Histopathological Criteria Annals of Neurology 2011; 69: 197-201. IF: 11.193 156. Benedetti L, Briani C, Fazio R, Paolasso I, Comi C, Luigetti M, Sabatelli M, Giannini F, Schenone A, Nobile-Orazio E, Cocito D. Rituximab in patients with CIDP: A report of 13 cases and review of the literature IF: 4.924 Journal of Neurology Neurosurgery and Psychiatry 2011; 82: 306-8. 157. Peters MJH, van Nes SI, Vanhoutte EK, Bakkers M, van Doorn PA, Merkies ISJ, Faber CG; on behalf of the PeriNomS Study group (Barreira AA, Bennett D, van den Berg LH, van den Bergh PY, Bril V, Cornblath DR, Dalakas M, Devigili G, van Doorn PA, Faber CG, Fisher MA, Gorson KC, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Illa I, Katzberg H, Kieseier BC, van de Kooi AJ, Lauria G, Léger JM, Lewis RA, Lunn MP, Merkies IS, Nobile-Orazio E, Notermans NC, Padua L, Pouget J, Reilly MM, Smith B, de Visser M, Walk D) Revised normative values for grip strength with the Jamar dynamometer Journal of the Peripheral Nervous System 2011; 16: 47-50 IF: 2.570 158. Nobile-Orazio E, Giannotta C Testing for anti-glycolipid IgM antibodies in chronic immune-mediated demyelinating neuropathies Journal of the Peripheral Nervous System 2011; 16 (Supplement): 18-23 IF: 2.570 159. Cocito D, Grimaldi S, Paolasso I, Falcone Y, Antonini G, Benedetti L, Briani C, Fazio R, Jann S, Matà S, Sabatelli M, Nobile-Orazio E. Immunosuppressive treatment in refractory chronic inflammatory demyelinating polyradiculoneuropathy. A nationwide retrospective analysis. European Journal of Neurology 2011; 18: 1417–1421 IF: 4.162 160. Judica E, Nobile-Orazio E Le neuropatie in corso di vasculite e di malattie reumatologiche. Reumatismo 2011; 63: S2:30-33. IF: n.n. 161. Riva N, Gallia F, Iannaccone S, Corbo M, Terenghi F, Lazzerini A, Cerri F, Comi G, Quattrini A, Nobile-Orazio E. Chronic motor axonal neuropathy Journal of the Peripheral Nervous System 2011; 16: 341-346 IF: 2.570 162. Mazzeo A, Stancanelli C, Russo M, Granata F, Gentile L, Di Leo R, Vita G, Nobile-Orazio E, Toscano A. Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. Muscle and Nerve 2012; 45(3): 451-452 IF: 2.314 163. Umapathi T, Hughes RA, Nobile-Orazio E, Léger JM. Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. Cochrane Database of Systematic Review 2012; Apr 18;4:CD003217. IF: 5.703 164. Nobile-Orazio E, Cocito D, Jann S, Uncini A, Beghi E, Messina P, Antonini G, Fazio R, Gallia F, Schenone A, Francia A, Pareyson D, Santoro L, Tamburin S, Macchia R, Cavaletti G, Giannini F, Sabatelli M, for the IMC Trial Group Intravenous immunoglobulin versus intravenous methylprednisolone for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial. Lancet Neuorlogy 2012, 11: 493-502. IF. 23.917 165. Vanhoutte EK, Faber CG, Merkies IS and the PeriNomS Study Group (Barreira AA, Bennett D, van den Bergh PY, Bril V, Devigili G, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Illa I, Katzberg H, van der Kooi AJ, Léger JM, Lewis RA, Lunn MP, Nobile-Orazio E, Padua L, Pouget J, Reilly MM, van Schaik I, de Visser M. MRC sum-score in the ICU: good reliability does not necessarily reflect "true reliability". Muscle and Nerve. 2012; May; 45(5):767-8 (Letter) IF: 2.314 166. Lunn MP, Nobile-Orazio E. Eduardo Nobile-Orazio 16 167. 168. 169. 170. 171. 172. 173. Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies. Cochrane Database Syst Rev. 2012 May 16;5:CD002827. IF: 5.703 Vanhoutte EK, Faber CG, van Nes SI, Jacobs BC, van Doorn PA, van Koningsveld R, Cornblath DR, van der Kooi AJ, Cats EA, van den Berg LH, Notermans NC, van der Pol WL, Hermans MC, van der Beek NA, Gorson KC, Eurelings M, Engelsman J, Boot H, Meijer RJ, Lauria G, Tennant A, Merkies IS; PeriNomS Study Group (Barreira AA, Bennett D, van den Bergh PY, Bril V, Devigili G, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Illa I, Katzberg H, van der Kooi AJ, Léger JM, Lewis RA, Lunn MP, Nascimento OJ, Nobile-Orazio E, Padua L, Pouget J, Reilly MM, van Schaik I, Smith B, de Visser M, Walk D). Modifying the Medical Research Council grading system through Rasch analyses. Brain. 2012;135 :1639-49. IF: 11.193 Padua L, Briani C, Truini A, Aprile I, Bouhassirà D, Cruccu G, Jann S, Nobile-Orazio E, Pazzaglia C, Morini A, Mondelli M, Ciaramitaro P, Cavaletti G, Cocito D, Fazio R, Santoro L, Galeotti F, Carpo M, Plasmati R, Benedetti L, Schenone A. Consistence and discrepancy of neuropathic pain screening tools DN4 and ID-Pain. Neurological Sciences 2013; 34 (3): 373-7. IF: 1.412 Nobile-Orazio E Treatment of chronic immune-mediated neuropathies: Impact of the Rare Diseases Centers network in Italy. Revue Neurologique 2013: 169: S33-S38 IF: 0.499 Nobile-Orazio E, Gallia F Multifocal Motor Neuropathy: Current Therapies and Novel Strategies Drugs 2013; 73:397-406 IF: 4.633 Nobile-Orazio E, Giannotta C, Musset L, Messina P, Léger JM Sensitivity and predictive value of anti-GM1/galactocerebroside IgM antibodies in multifocal motor neuropathy. Journal of Neurology Neurosurgery and Psychiatry 2013 (Epub August 1, 2013) IF: 4.924 Nobile-Orazio E, Léger JM, Lewis RA, Bolino A, Shy ME, Cornblath DR. Meeting Report: 2013 Peripheral Nerve Society Biennial Meeting, Saint-Malo, France, June 29–July 3, 2013 (Editorial) Journal of the Peripheral Nervous System 2013; 18: 197–198. IF: 2.570 Galeotti F, Massari M, D'Alessandro R, Beghi E, Chiò A, Logroscino G, Filippini G, Benedetti MD, Pugliatti M, Santuccio C, Raschetti R; ITANG study group (Michelucci R, Riguzzi P, Sacquegna T, Borghi AM, Neurologiche S, Mussuto V, De Massis P, Cirignotta F, Rinaldi R, Neri W, Guidi C, Rosaria M, Granieri E, Simioni V, Nichelli P, Mandrioli J, Guidetti D, Terlizzi E, Terzano MG, Pavesi G, Rasi F, Callegarini C, Marcello N, Bondavalli M, Ravasio A, Curro'Dossi M, Mauro A, Minardi C, Greco G, Amidei S, Montanari E, Medici D, Riccardi T, D'Adda E, Bettoni L, Abruzzi L, Agostoni E, Basso F, Magnoni A, Crespi V, Repaci M, Cheldi A, Bellotti M, Ferrarese C, Curto NA, Meola G, Rotondo G, Nobile-Orazio E, Terenghi F, Sasanelli F, Galbussera A, Mattioli M, Tiriticco Azienda M, Nascimbene C, Vanotti A, Jann S, De Toni Franceschini L, Silani V, Ticozzi N, Comi G, Fazio R, Perrone P, Giorgetti A, Romorini A, Bassi P, Santoro D, Bresolin N, Tonietti S, Suardelli M, Bezzi G, Baldini D, Clerici AM, Cafazzo G, Porazzi D, La Spina I, Grampa G, Zarcone D, Perini M, Poloni M, Agazzi E, Filosto M, Padovani A, Besana R, Donati E, Magni E, Arnaboldi M, Belcastro V, Guidotti M, Riva M, Vitelli E, Previdi P, Micieli G, Candeloro E, Dallocchio C, Arbasino C, Calvo A, Moglia C, Vercellino M, Ferrero B, Pignatta P, Oddenino E, Imperiale D, Leotta D, Gionco M, Ravetti C, Cavallo R, Di Vito N, Geda C, Bortolotto S, Luda di Cortemiglia E, Liotta G, Ursino E, Palermo M, Ambrogio L, Meineri P, Dotta M, Ghiglione P, Maistrelli J, Onorato S, Leone M, Papurello DM, Villani A, Conti R, Coppo F, Tesser F, Testa L, Cattaneo SI, Penza MT, Gusmaroli G, Savio K, Perla F, Mondovı C, Pisano F, Poglio F, Pradotto L, Bottacchi EF, Livrea P, Federico F, Trojano M, Covelli V, Maggio B, Santamato V, Passarella B, Zimatore G, Trianni G, Ciardo G, Interno S, Marchini C, Zambito Marsala S, Michieli G, Borsato C, Didone G, Frasson E, Polo A, Argentiero V, Romeo V, Perlotto N, L'Erario R, Micaglio G, Rosso T, Bruno S, Giometto B, Serena M, Quatrale R, Gastaldo E, Perini F, DiLeone M, Casano A, Silvestri L, Burlina A, Munerati V, Eduardo Nobile-Orazio 17 174. 175. 176. 177. D'Anna S, Sanson F, Sartori V, Moretto G, Squintani G, Monaco S, Benedetti MD, Fusina S, Bianconi C, Pimazzoni F, Bonometti A, Zanette G, Turatti M, Leoni S, Mura G, Ticca A, Marchi P, Manca D). Risk of Guillain-Barré syndrome after 2010-2011 influenza vaccination. European Journal of Epidemiology 2013; 28 (5): 433-44. IF: 5.118 Vanhoutte EK, Faber CG, Merkies IS; PeriNomS study group (Van den Bergh P, Bril V, van Doorn PA, Faber CG, Gorson K, Hahn A, Hughes RA, van der Kooi A, Lauria G, Leger JM, Lewis R, Lunn M, Merkies IS, Nobile-Orazio E, Notermans NC, Querol L, van Schaik I, Zollinger D, Zitterstein A, van Engelen B, Barreira AA, Bennett D, van den Berg P, Cornblath DR, Devigili G, Hadden RD, Illa I, Padua L, Pouget J, Reilly MM, de Visser M, van Nes SI, Walk D.) 196th ENMC international workshop: Outcome measures in inflammatory peripheral neuropathies 8-10 February 2013, Naarden, The Netherlands. Neuromuscular Disorders 2013; 23(11): 924-33. IF: 3.464 Nobile-Orazio E Treatment dependence in chronic inflammatory demyelinating polyradiculoneuropathy: is it related to disease phenotype or to the therapy used? (Editorial commentary) Journal of Neurology Neurosurgery and Psychiatry 2013 (Epub December 11, 2013) IF: 4.924 Nobile-Orazio E. Chronic Inflammatory demyelinating polyradiculoneuropathy. Where we are, where we should go. Journal of the Peripheral Nervous System 2014 (in Press) IF: 2.570 Di Fonzo A, Ronchi D, Gallia F, Cribiù FM, Trezzi I, Vetro A, Della Mina E, Limongelli I, Bellazzi R, Ricca I, Micieli G, Fassone E, Rizzuti M, Bordoni A, Fortunato F, Salani S, Mora G, Corti S, Ceroni M, Bosari S, Zuffardi O, Bresolin N, Nobile-Orazio E, and Comi G. Lower motor neuron disease with respiratory failure caused by a novel MAPT mutation. Neurology 2014 (in Press) IF: 8.249 b) Capitoli su libri o relazioni pubblicate in esteso su libri 1. Nobile-Orazio E. 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