Research News Spencer Gibson, Ph.D. Interim Director—Research Institute of Oncology and Hematology
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Research News Spencer Gibson, Ph.D. Interim Director—Research Institute of Oncology and Hematology
Research News Spencer Gibson, Ph.D. Interim Director—Research Institute of Oncology and Hematology June 2015 Inside this issue: Funding Success 1 Trainee Success 2 In the News 3 Presentations 4 CCCTN 4 Publications 5 Funding opportunities 6 COMING EVENTS INTRODUCTION FUNDINGSUCCESS Summer is here and people are looking forward to their well deserved vacations. Research however never takes a vacation. In the next month we will find out about research grants from Research Manitoba, CIHR and Cancer Research Society. We will also have deadlines for letter of intent for up coming grant competitions and conference registrations. On this note, we will be giving information on how to apply for travel awards to the CCRA conference soon. Congratulations to Dr Sara Israel, coinvestigator with Mahmud Torabi on a Children Hospital Research Institute of Manitoba operating grant entitled “Geographical variation and related risk factors with childhood leukaemia in Manitoba”. August 13—MICB Summer Student Symposium Thanks to everyone who attended the State of the Institute talk. Your feedback is much appreciated. Congratulations to Ms Zelda Lichtensztejn, (McManus lab) winner of the 2015 Congratulations to Ms Zelda MICB Merit Award. Lichtensztejn, (McManus lab) Have a great sumwinner of the 2015 MICB mer! Merit Award! August 15—Abstracts due for Canadian CLL Mee ng Follow us on twitter @RIOH_Mb Signe Penner-Goeke (McManus Lab) was awarded a full scholarship and immediate enrollment into the PhD program at Ludwig Maximilian University of Munich to study neurosciences. Amanda Moodie (Myal lab) received an NSERC summer studentship. Rob Bergen (supervised by Lawrence Ryner) received an $18,000 University of Manitoba Graduate Fund (UMGF) scholarship for this thesis entitled "Optimizing and Advancing Multiparametric Magnetic Resonance Imaging for BioRebecca Dielschneider joins the logically Guided Manitoba delegation at Bio2015 Radiotherapy" in Philadelphia to receive the BIOTECanada’s Gold Leaf Award (see page 2 for details) TRAINEE SUCCESS Lexi Ciapala (Gibson lab), recipient of the Terry Fox Research Institute Rising Star scholarship, was invited to blog about her first TFRI Annual Scientific Meeting. Lexi is currently in BC learning about CRISPR http://www.tfri.ca/en/ NewsEvents/blogs/ BlogPost/tfriblog/2015/05/22/st.-john-s -to-vancouver-tfriresearch-takes-amanitoba-student-fromcoast-to-coast Lexi Ciapala (Gibson lab) blogs about her first TFRI Meeting Rebecca Dielschneider (Gibson lab) was awarded the BIOTECanada Gold Leaf Young Leader in Biotechnology Research. She was nominated by the Life Sciences Association of Manitoba received her award from Minister Kevin Chief during the opening day of the BIO International Convention in Philadelphia this June. “[…] Rebecca’s groundbreaking research focused Follow us on twitter @RIOH_Mb Page 2 on cancer of the immune system embodies the strength of Canada’s young research community and the postsecondary institutions that support them,” says Andrew Casey, President and CEO BIOTECanada. “I congratulate Rebecca on receiving the BIOTECanada 2015 Gold Leaf Award for Young Leader in Biotechnology Research and also extend appreciation to the University of Manitoba and CancerCare Manitoba for supporting Rebecca’s important research.” http://news.umanitoba.ca/ graduate-student-topperformer/ Earlier this month, Rebecca also 2nd place in the National 3 Minute Thesis. From the announcement, “More than 1,500 students from 35 institutions presented their research in this year’s competition. Your work impressed both judges and participants alike. Our judges’ panel noted Rebecca Dielschneider (Gibson lab) accepting her Gold Leaf Award from BIOTECanada Photo from Darren Fast @umanitobaTTO that you did a good job of explaining the science on a very compelling topic. Mitacs CEO, Alejandro Adem, said he couldn’t find a way to improve on your presentation.” http://news.umanitoba.ca/ student-wows-nationalaudience/ Erin McAndrew (McManus lab) received the University of Manitoba College of Medicine Power Award at the Manitoba competition during the Canadian Student Health Research Forum on June 3rd. Rebecca Dielschneider and Laura Thompson (McManus lab) were award 2nd place and honourable mention, respectively, for their posters. Rebecca won a silver medal in the national CIHR poster competition. Medical Physics Ph.D. Student Hongyan Sun (supervisor Stephen Pistorius) competed as one of seven finalists in the Young Investigator Symposium at the World Congress on Medical Physics and Biomedical Imaging held in Toronto June 7 -12, 2015. Asha Singha (Katyal lab) won a poster award at the 5th annual Manitoba Neurosciences Network meeting on June 12th. IN THE NEWS Page 3 Afshin Raouf’s recent publication in Endocrine-Related Cancer was featured in the Winnipeg Free Press. “Endocrine-Related Cancer journal editor Dr. Charis Eng -- also a director with the renowned Cleveland Clinic in Ohio -- confirms that Raouf's study is a first-of-its-kind breakthrough that could help prevent breast cancer in patients. ‘Uncovering processes in healthy tissue will lead to future strategies of treating or preventing breast pathology,’ Eng wrote in an email to the Winnipeg Free Press.” http://www.winnipegfreepress.com/arts-and-life/life/health/deciphering-cancers-code307331241.html With summer here, it’s time to get out your bikes and enjoy the many paths and bike lanes Winnipeg has to offer. Ryan Zarychanski has made a video with advice on bike helmet safety. http://news.umanitoba.ca/bicycle -helmet-saftey-tips/ Dr Julian Kim was featured in the Winnipeg Free Press for his new collaboration with Dr Pruthi at the Mayo Clinic to determine an iPad-enabled risk assessment and prevention tool. http://www.winnipegfreepress.com/local/breast-cancer-app-puts-patient-first-310005691.html PRESENTATIONS Geoff Hicks presented preliminary data from the CIHR FASD research team at the 6th annual Manitoba Neuroscience Symposium. This session was chaired by Sachin Katyal. Medical Physics Department delivered 8 scientific talks and 1 scientific poster at the recent World Congress on Medical Physics and Biomedical Engineering, held this past week (June 712) in Toronto. These were presented by graduate students Pawel Siciarz, Azeez Omotaya, Troy Teo, and Hongyan Sun, as well as post-doctoral fellow Pete McCowan and physics resident Yannick Poirier. Sabine Mai and the Genomics Centre for Cancer Research and Diagnosis (GCCRD) hosted Intermediate Microscopy workshop. Seven participants Canada, the US, China and Italy attended. Sara Israels, Eileen McMillan-Ward, Hong Wang, Victor Blanchette and Margaret Rand’s poster “Determination of threshold agonist concentrations for whole blood aggregation using the multiplate® analyzer” at the International Society on Thrombosis and Haemostatis 2015 was ranked in the top 20% at the conference. Follow us on twitter @RIOH_Mb Page 4 CANADIAN CANCER CLINICAL TRIALS NETWORK (CCCTN OR 3CTN): CancerCare Manitoba (CCMB) has joined the Canadian Cancer Clinical Trials Network (3CTN), a pan-Canadian network of cancer agencies working together to improve the lives of cancer patients and individuals at risk of cancer by increasing the capacity of Canadian cancer centres to effectively conduct academic clinical trials that address questions of importance to Canadians and the Canadian healthcare system. The Clinical Investigations Office (CIO) provides the infrastructure for clinical trials at CCMB. As members on the 3CTN Steering Committee, CIO Medical Director, Dr. Rajat Kumar, and Manager, Kathryn Dyck, have been active in creating the framework for the new initiative at CCMB. With a focus on academic trials (trials developed by and coordinated by academic investigators) the network aims to improve patient access to clinical trials, increase enrollment and streamline trial conduct. 3CTN will be funded by multiple organizations across Canada, including organizations such as federal cancer foundations, charitable organizations and provincial cancer agencies, who have agreed to invest in the development of academic clinical trials in Canada. With pooled funding, 3CTN aims to address the many challenges faced by cancer clinical research institutions. Based on our provincial population, CCMB anticipates receiving up to $231,300/yr over the next four years. The additional funding will be used to support the new staff required to meet the goals of the network, and will increase our capacity and capability to undertake under-funded practicechanging clinical trials. 2015 CANADIAN CANCER RESEARCH CONFERENCE The Canadian Cancer Research Alliance is hosting the 2015 Canadian Cancer Research Conference from November 8-10 at the Hotel Bonaventure in Montreal. http://www.ccra-acrc.ca/index.php/ ccrc-home Early bird registration to attend this national conference is due by August 31. http://www.ccra-acrc.ca/index.php/registration Did you receive a CCMF Operating grant in 2013 or 2014? Progress reports and end-of-grant reports are due to Eilean McKenzie-Matwiy on August 14. Follow us on twitter @RIOH_Mb PUBLICATIONS Page 5 Stop-Smoking Medication Use, Subsidization Policies, and Cessation in Canada. White CM, Rynard VL, Reid JL, Ahmed R, Burkhalter R, Hammond D. Am J Prev Med. 2015 May 29. Laboratory testing for platelet function disorders. Israels SJ. Int J Lab Hematol. 2015 May;37 Suppl 1:18-24. Mammography rates for breast cancer screening: a comparison of First Nations women and all other women living in Manitoba, Canada, 1999-2008. Demers AA, Decker KM, Kliewer EV, Musto G, Shu E, Biswanger N, Fradette K, Elias B, Griffith J, Turner D. Prev Chronic Dis. 2015 May 28;12:E82. Quantitative superresolution microscopy reveals differences in nuclear DNA organization of multiple myeloma and monoclonal gammopathy of undetermined significance. Sathitruangsak C, Righolt CH, Klewes L, Tammur P, Ilus T, Tamm A, Punab M, Olujohungbe A, Mai S. J Cell Biochem. 2015 May;116(5):704-10. Optimal uptake rates for initial treatments for cervical cancer in concordance with guidelines in Australia and Canada: Results from two large cancer facilities. Kang YJ, O'Connell DL, Tan J, Lew JB, Demers A, Lotocki R, Kliewer EV, Hacker NF, Jackson M, Delaney GP, Barton M, Canfell K. Cancer Epidemiol. 2015 May 21. Routine filtration of hematopoietic stem cell products: the time has arrived. Paulson K, Gilpin SG, Shpiruk TA, Anjos K, Tulloch M, Giftakis A, Blankstein AR, Szwajcer D, Wall DA. Transfusion. 2015 May 18. Claudin 1 promotes migration and increases sensitivity to tamoxifen and anticancer drugs in luminal-like human breast cancer cells MCF7. Zhou J, Blanchard A, Wang N, Ma X, Han J, Schroedter I, Leygue E, and Myal, Y. In Press: Cancer Investigation, 2015 Prospective functional outcomes in sequential population based cohorts of stage III/ IV oropharyngeal carcinoma patients treated with 3D conformal vs. intensity modulated radiotherapy. Kerr P, Myers CL, Butler J, Alessa M, Lambert P, Cooke AL. J Otolaryngol Head Neck Surg. 2015 May 13;44:17. Functional Myeloid-Derived Suppressor Cell Subsets Recover Rapidly after Allogeneic Hematopoietic Stem/Progenitor Cell Transplantation. Guan Q, Blankstein A, Anjos K, Synova O, Tulloch M, Giftakis A, Yang B, Lambert P, Peng Z, Cuvelier GD, Wall DA. Biol Blood Marrow Transplant. 2015 May 9. Fast analytical scatter estimation using graphics processing units. Ingleby H, Lippuner J, Rickey DW, Li Y, Elbakri I. J Xray Sci Technol. 2015;23(2):119-33. Overall Quality of Life Assessment in the Patients Undergoing External Beam Radiation in Outpatient Radiation Oncology Department Rashmi Koul , Richard Tse, Erwin Karreman, Arbind Dubey , Patricia Tai International Journal of HematologyOncology and Stem Cell Research, July. 9, (3):1-9. Follow us on twitter @RIOH_Mb Brent Guppy (McManus lab) presenting his results at the Canadian Student Health Research Forum Page 6 FUNDING OPPORTUNITIES HTTPS://WWW.GOOGLE.COM/CALENDAR/EMBED? SRC=MANITOBAINSTITUTEOFCELLBIOLOGY%40GMAIL.COM&CTZ=AMERICA/WINNIPEG July 1—CanFASD Travel award - FAAF NSERC Idea to Innovation - Lung Cancer Research Foundation grant - Helen Hay Whitney foundation post-doctoral fellowship - JSPS Invitation Fellowship for Oncologist - Histiocytosis Association Research Grant July 2—LOI CCSRI Quality of Life Research grant - North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Midlevel career development, nursing, pharmaceutical products, young investigator, Crohn’s and colitis, and nutrition research grants July 7- NSERC Idea to Innovation - FAAF Dept of Defense Bone Marrow Failure Research Program : Idea award - Weston brain institute transformational research –neurodegenerative disease of aging July 15—NeuroDevNet Brain Canada studentship and post-doctoral fellowship - Yamagiwa-Yoshida memorial international study award July 21—Dept of Defense Bone Marrow Failure Research Program : Idea award July 22—FAAF Dept of Defense Ovarian cancer research program pilot award - AACR Bristol Myers Squibb Oncology Fellowship in clinical cancer research - AACR Amgen Inc Fellowship in clinical/translational cancer research - Dept of Defense Ovarian cancer research program clinical translation award - Judah Folkman Fellowship for Angiogenesis research July 25—Pre-application Department of Defense – Prostate Cancer Research Program – Idea Development Award July 27—Registration CIHR Foundation scheme 2nd live pilot July 29—FAAF Dept of Defense Ovarian cancer research program investigator initiated research award July 31—Federation of Chinese Canadian Professionals - Wiley Prize in Biomedical Science (team award) Aug 1—UM internal deadline CIHR Foundation scheme 2nd live pilot - CureSearch for Children’s cancer Saturday, July 25th, 2015 Grand Beach Entertainment Centre Follow us on twitter @RIOH_Mb