CURRICULUM VITAE EDUCATION: Basic

CURRICULUM VITAE
STEVEN N. MINK, M.D.
EDUCATION:
Basic
Philadelphia Public Schools to high school
1964-1968
B.S. Albright College, Reading, Pennsylvania
1968-1972
M.D. Temple University School of Medicine,
Pennsylvania
POST GRADUATE TRAINING:
1972-1975
Intern and Medical Residency
Montefiore Hospital, University of Pittsburgh
Pittsburgh, Pennsylvania
1975-1977
Clinical Pulmonary Fellowship
Georgetown University Hospital
Washington, D.C.
1977-1980
Research Pulmonary Fellowship
University of Manitoba
Health Science Centre
Winnipeg, Manitoba, Canada
Steven N. Mink, MD
PROFESSIONAL APPOINTMENTS:
1980-1982
Associate Foundation Scientist Southwest Foundation for Research and
Education San Antonio, Texas
1980-1982
Medical Director, Pulmonary Function Laboratory , Audie L. Murphy Memorial
Veterans Hospital and Texas County Hospital, San Antonio, Texas
1980-1982
Assistant Professor of Medicine, University of Texas Health Science Centre at
San Antonio, San Antonio, Texas
Section of Pulmonary and Critical Care Medicine
1982-July 1985
Assistant Professor of Medicine,
Section of Respiratory Disease
University of Manitoba
Winnipeg, Manitoba, Canada
1985-2000
Associate Professor of Medicine
Section of Respiratory Diseases
University of Manitoba
Winnipeg, Manitoba, Canada
1982-present
Attending Physician
Respiratory Centre
Health Sciences Centre
Winnipeg, Manitoba, Canada
1988-present
Attending Physician
Section of Critical Care Medicine
Intensive Care Unit
St. Boniface Hospital
Winnipeg, Manitoba, Canada
1984 to 1996
Adjunct Faculty, Department of Physiology
University of Manitoba
July 1997 March 1998
Acting Head,
Section of Respiratory Diseases
University of Manitoba
Winnipeg, Manitoba
April 1998 to 2006
Section Head,
Section of Respiratory Diseases,
Univ of Manitoba
June 2000 to present
Professor of Medicine
University of Manitoba
July 2002 to present
Professor, Department of Pharmacology and Therapeutics
University of Manitoba
2
Steven N. Mink, MD
BOARD CERTIFICATION:
1975
American Board of Internal Medicine
1978
American Subspecialty Boards in Pulmonary
Disease
1991-2001
2001-2021
ABIM Critical Care Certifying Examination
HONORS AWARDS:
1972
AOA Medical Honorary Society, Temple University
1979-1980
American Lung Association Training Fellowship
1980-1982
NIH Young Investigator Research Award
1983-1986
Manitoba Health Research Scholarship
SOCIETIES
American Thoracic Society
American Physiological Society
American Society Clinical Investigation
American College of Physicians
American College of Chest Physicians
Canadian Thoracic Society
European Respiratory Society
President, Manitoba Thoracic Society
1997 to 1998
COMMITTEES
2002 to 2006
Chair, Promotions Committee Department of Internal Medicine
2000-2002
Alberta Heritage Foundation for Medical Research Clinical Investigatorship Committee
1999 to 2001
Member Heart and Stroke Foundation Grants Committee
1987-90
Member, Medical Research Council, Respiratory
Grants Review Committee
1987-present
Member, Central Animal Care Committee
University of Manitoba
MEDICAL LICENSES:
Manitoba, Canada
Texas, U.S.A.
3
Steven N. Mink, MD
CLINICAL ACTIVITIES:
Member of Long Term Ventilation Program
Respiratory Consultant at Health Sciences Centre and St Boniface Hospital 8 weeks per year
Respiratory Clinic ½ day per week
Critical Care Attending 8 weeks per year
Attending Physician Chronic Respiratory Ward, Deer Lodge Hospital 2006 to present
4
Steven N. Mink, MD
RESEARCH SUPPORT
Cumulative Competitive Research Grants Awarded
C= competitive
Granting
Agency
Subject
Comp
Awarded
Years
Principal
investigator
Co-investigators
Medical
Research
Council
Canadian
Heart and
Stroke
Foundation
Children’s
Hospital
Foundation
Wave-speed
factors affecting
expiratory flow.
Ventricular
mechanics in
pulmonary
emphysema
The
pharmacodynami
cs and
pharmacokinetics
of epinephrine in
the treatment of
anaphylactic
shock
Interactions
between
histamine H3
receptors and
alpha 2
adrenoceptors on
cardiac function
in sepsis
C
Total=
$434,154
1983-96
Mink
None
C
Total=
$543,000
1983-98
Mink
None
C
$96,000
2000-2002
Mink
Becker
Simons
$42,500
July 2002to June
2003
C
$40,000
/year
20032006
Mink
None
Left ventricular
performance in
gram negative
sepsis
Ventricular
mechanics
in experimental
anaphylactic
shock
Multi-centered
clinical trial of
lung volume
reduction surgery
in emphysema
Mechanisms of
increased
maximal flow in
experimental
volume reduction
Surgery
C
$460,000
1990-2004
RB Light
H Jacobs
Mink
D Bose
$40,000 year
2004-2007
C
$270,000
1988-1999
W Kepron
Mink
C
$1 million
over 5 years
for 11 centres
1997-2002
Larry Tan
H Unruh
S Mink
C
$35,000/year
Jan
2003-Dec
2003
Mink
L Tan
Canadian
Heart
and
Stroke
Foundation
Canadian
Heart
and Stroke
Foundation
Canadian
Heart
and Stroke
Foundation
Medical
Research
Council
Manitoba
Medical
Services
Foundation
5
Steven N. Mink, MD
Canadian
PathoHeart and
physiology of
Stroke
lactic acidosis in
Foundation
experimental
sepsis
Heatlth
Lysozyme
Sciences
inhibitors: novel
Centre
agents in the
Foundation
treatment of
cardiovascular
collapse in septic
shock
Canadian
Lysozyme: a
Institutes of
novel mediator
Health
of cardiac
Research
adrenergic
dysfunction in
septic shock
Heatlth
Sciences
Centre
Foundation
Health
Sciences
Centre
Foundation
Lysozyme
inhibitors: novel
treatment of
vasospasm in
aneurismal
subarachnoid
hemorrhage.
A new treatment
approach to
septic shock
C
$35,000
/year
1999-2002
Carla
Chrusch
S Mink
C
$27,000/year
2003-2004
S Mink
C
$76,000/year
2005-2009
S Mink
H Jacobs
D Bose
RB Light
C
$30,745
2006-2007
S Mink
M West
C
$30496
20010
S Mink
Competitive Research Grants Submitted
Canadian
Heart
and
Stroke
Foundation
The
role
of
impaired hepatic
mitochondrial
bioenergetics in
the development
of lactic acidosis
in septic shock.
$61000 per year
2014-2017
S Mink
C
Selective Contract Research Grants (Ncom= noncompetitive)
Grant
TITLE
COM
Awarded
Years
Agency
Principle
Investigator
P
Fernyhough
Coinvestigator
6
Steven N. Mink, MD
Astra, Inc
Multi-center trial
to determine the
effects of double
the dose of
inhaled steroid in
acute asthma
Glaxo
A comparison of
Wellcome
fluticasone
propionate with
beclomethasone
dipropionate in
adult asthma
New Mechanical
Spiration,
Device for
Inc
Volume
Reduction Surgery
Respironics PLVC Continuum
Ventilator Study
Respironics Trilogy Ventilator
Study
Respironics Maui Ventilator
Study
Ncom
$100,000
97-98
Mink
None
Ncom
$60,000
1993-1994
Mink
None
Ncom
$200,000
2000-2002
Mink
Tan
Ncom
$20,00
2004-2006
Mink
Ncom
$18000
2008-2009
Mink
Ncom
$16000
2008-2009
Mink
RESEARCH TRAINEES.
Graduate Students.
Jose Gotes Palazeuolos 2010 to 2013. Masters Candidate in Department of Pharmacology and Therapeutics.
Awarded October 2013.
Mohammad Ashfaque. 2013 to present. Supervisory committee for Ph’D candidate in the Department of
Immunology.
Schaafsma Dedmer 2008/7 to 2011/6. Co-supervisor. Post –doctorate. University of Manitoba. Project
description Smooth muscle contraction.
Gordon Buduhan: Masters Degree, Department of Surgery, University of Manitoba, “Effect of
acute lung volume reduction on lung mechanics and maximal flow in a canine model of upper lobe
emphysema.” 2003-05; Thesis accepted 2005.
Muftah Al-Mohamed: Masters Degree, Department of Surgery, University of Manitoba, “Mechanisms of
decreased maximal flow in lung volume reduction surgery ”, July 2001-02.
E Ewing Bui: Masters Degree, Department of Surgery, University of Manitoba, “Effects of post-pulmonary
resection on maximal deflation in normal canine lungs and in a unilobar emphysema model”, Thesis 2000.
X Li, Masters Degree, Department of Physiology, University of Manitoba; "Histamine H3 activation causes
cardiac depression in experimental sepsis," 1996 to 1999. Thesis accepted June 99.
Arturo Gomez, Ph'D Program in Department of Physiology, University of Manitoba, "Left ventricular
mechanics in experimental pulmonary emphysema", 1984 to 1988. Recipient of "Cardiovascular Biology
Award" of the St Boniface General Hospital Research Foundation on behalf of Faculty Committee for
7
Steven N. Mink, MD
Graduate Studies for excellence in research.
J Eng, Masters Program in Department of Physiology, University of Manitoba, "Left ventricular function in
experimental sepsis", 1988 to 1989.
Research Fellows or Fellows Supervised in their Research Year.
C Jadue, MD, 1984 to 1985
H Greville, MD, 1984 to 1986.
A Gomez, MD, 1984 to 1988 (Recipient Department Medicine Research Prize).
E Correa, MD, 1988 to 1990
P Jha, MD, 1990 to 1992 (Recipient Department Medicine Research Prize).
M Gu, MD, Ph'D MRC Fellowship.
S Sharma, MD 1992 to 1993 (Recipient Department Medicine Research Prize).
J Yu, MD, Ph'D 1993 to 1994.
C Bands, MD 1995 to 1996 (Recipient Department Medicine Research Prize).
D Patel, MD 1996 to 97
G Eschun, MD 1998 to 2000, enrolled in Clinical Investigator Program.
E Bautista, MD 1998 to 2000
D Ewing Bui MD 1999 -2000(MSc, Dept of Surgery). recipient of the CHEST Foundation and Boehringer
Ingelheim Pharmaceuticals, Inc Clinical Research Trainee Award in COPD for CHEST 2000 to be
recognized during the Awards Ceremony at this year’s ACCP meeting.
Ali- Mohamed, Muftah 2001-2002 (MS, Dept of Surgery)
Gordon Buduhan 2003-2005 (MS, Dept of Surgery) (Recipient Department of Surgery Research Prize).
Luis E Santos Martinez 2008 to 2009
Jose Gotes Palazeuolos 2009 to 2010.
Medical Residents.
J Rosenberg, MD 1995 (Recipient Department Medicine Research Prize).
G Eschun, MD 1996 to 97
Medical Students.
8
Steven N. Mink, MD
J Elkin, Summers of 1994 and 1995 (winner of 1st and 2nd year research prizes).
Selected Invited Talks and Visiting Professorships.
1). Mexican Society of Cardiology 2012 Meeting, Puerto Viarta
2). Invited Speaker, University of Mississippi, Sept 2007
3). Invited Speaker, Unviversity of Nevada, Reno Nevada, Nov 2007
4) Invited speaker, University of Alberta, October 2007
5). Invited Speaker “The National Meeting of the Mexican Society of Respiratory Diseases and Surgery of Thorax”
April 2005.
6). Invited Speaker, Western Respiratory Disease Symposium (WRDS) April 24th to 27th 2003.
7)..
American Thoracic Society International Meeting Year 2000 in the Clinical Topics Symposium entitled,
“Effects of hypoxia and hypercapnia on the heart and pulmonary circulation”
8). International Conference of Respiratory Physiology and Clinical Application, Nov 2-4, 1998 at Zhong Sham
Hospital Shanghai Medical University, People’s Republic of China.
9). Instituto Nacional de Cardiologica Ignacio Chavez, Cardiopulmonary interaction in the critically ill patient.
University National of Mexico, UNAM. October 21-24, 97.
10). Visiting Professor, University of Lousiville, Kentucky October 15-18, 1996.
11). Visiting Professor, University of Alberta, 1994.
12) Visiting Professor, Wayne State University 1988
13) Visiting Professor, University of Calgary, 1987.
14). Visiting Professor, University of British Columbia, 1984.
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Steven N. Mink, MD
PUBLICATIONS
I. Publications in Referred Journals.
i. Published.
1.
Mink, S.N., M. Zeismann, and L.D.H. Wood. Mechanisms of increased maximum expiratory flow during
HeO2 breathing in dogs. J. Appl. Physiol.:Respir. Environ. Exercise Physiol. 47:490-502, 1979.
2.
Mink, S.N. and L.D.H. Wood. How does HeO2 increase maximum expiratory flow in human lung? J. Clin.
Invest.66:720-729, 1980.
3.
Mink, S.N., R.B. Light, and L.D.H. Wood. Effect of pneumococcal lobar pneumonia on canine lung
mechanics. J. Appl. Physiol.: Respir. Environ. Exercise Physiol. 50:283-291, 1981.
4.
Light, R.B., S.N. Mink, and L.D.H. Wood. Pathophysiology of gas exchange and pulmonary perfusion in
pneumococcal lobar pneumonia in dogs. J. Appl. Physiol.: Respir. Environ. Exercise Physiol.50:524-530,
1981.
5.
Mink, S.N., R.B. Light, T. Cooligan, and L.D.H. Wood. Effect of PEEP on gas exchange and pulmonary
perfusion in canine lobar pneumonia. J. Appl. Physiol.:Respir. Environ. Exercise Physiol.50:517-523, 1981.
6.
Light, R.B., S.N. Mink, and L.D.H. Wood. The effect of unilateral PEEP on gas exchange and pulmonary
function in canine lobar pneumonia. Anesthesiology 55(3):251-255, 1981.
7.
Cooligan, T., R.B. Light, L.D.H. Wood, and S.N. Mink. Plasma volume infusion in canine pneumococcal
pneumonia: Its effects on respiratory gas exchange and pneumonia size. Am. Rev. Respir. Dis.126:86-92,
1982.
8.
Light, R.B., T. Cooligan, L.D.H. Wood, and S.N. Mink. The physiology of recovery in experimental
pneumococcal pneumonia. Clin. Invest. Med.6:147-151, 1983.
9.
Mink, S.N. Mechanism of reduced maximum expiratory flow in methacholine-induced bronchoconstriction
in dogs. J. Appl. Physiol.: Respir. Environ. Exercise Physiol. 55:897-912, 1983.
10.
Mink, S.N. Expiratory flow limitation and the response to breathing a helium-oxygen gas mixture in a
canine model of pulmonary emphysema. J. Clin. Invest.73:1321-1334, 1984.
11.
Mink, S.N., J.J. Coalson, L. Whitley, H. Greville, and C. Jadue. Pulmonary function tests in the detection of
small airway obstruction in a canine model of bronchiolitis obliterans. Am. Rev. Respir. Dis.130:1125-1133,
1984.
12.
Arnup, M.E., H.W. Greville, L. Oppenheimer, S.N. Mink, and N.R. Anthonisen. Dynamic lung function in
dogs with compensatory lung growth. J. Appl. Physiol.57:1569-1576, 1984.
13.
Pare, P.D., L.A. Brooks, C.A. Coppin, J.L. Wright, S. Kennedy, R. Dahlby, S.N. Mink, and J.C. Hogg.
Density dependence of maximum expiratory flow and its correlation with small airway pathology in smokers.
Am. Rev. Respir. Dis.131:521-526, 1985.
14.
Jadue, C., H.W. Greville, J.J. Coalson, and S.N. Mink. Forced expiration and HeO2 response in canine
peripheral airways obstruction. J. Appl. Physiol.58(6):1788-1801, 1985.
15.
Pysczynski, D., S.N. Mink, and N.R. Anthonisen. Increased gravitational stress does not alter maximum
expiratory flow. J. Appl. Physiol., 59(1):28-33, 1985.
10
Steven N. Mink, MD
16.
Mink, S.N., H. Unruh, and L. Oppenheimer. Vascular and interstitial mechanics in canine pulmonary
emphysema. J. Appl. Physiol.59:1704-1715, 1985.
17.
Greville, H.W., M.E. Arnup, S.N. Mink, L. Oppenheimer, and N.R. Anthonisen. Maximum expiratory flow
reduction in pneumonectomized dogs. J. Appl. Physiol., 60:441-448, 1986.
18.
Mink, S.N., L. Whitely, and J.J. Coalson. Hemodynamics in dogs with pulmonary hypertension due to
pulmonary emphysema. Lung 164:41-54, 1986.
19.
Gomez, A. and S.N. Mink. Increased left ventricular stiffness impairs filling in dogs with pulmonary
emphysema in respiratory failure. J. Clin. Invest.78:228-240, 1986.
20.
Greville, H.W. and S.N. Mink. Density dependence of maximum expiratory flow in histamine
bronchoconstriction in dogs. J. Appl. Physiol.62:691-705, 1987.
21.
Mink, S. Experimental studies: In density dependence of maximal expiratory flow. Teculescy, D.B., Pride,
N. eds. Bull Eur Physiopath. Respir. 23:663-666, 1987 (Workshop Nancy 1986).
22.
Mink, S.N., H. Greville, and A. Gomez. Expiratory flow limitation in dogs with regional changes in lung
mechanical properties. J. Appl. Physiol. 64:162-173, 1988.
23.
Gomez, A., J. Eng, and S. Mink. Aminophylline has little positive inotropic effect and a slightly negative
diastolic effect on the left ventricle during hypoxic conditions in dogs. Am. Rev. Respir. Dis. 137:1296-1303,
1988.
24.
Mink, S.N., S.G. Holtby, D.J. Berezanski, L. Oppenheimer, and N.R. Anthonisen. Heterogeneity of maximal
lobar emptying rates in dogs with compensatory lung growth. J. Appl. Physiol. 67:1164-1170, 1989.
25.
Eng, J., and S. Mink. Insensitivity of maximum expiratory flow to bronchodilation in dogs. J. Appl. Physiol.
68:2006-2012, 1990.
26.
Gomez, A., R. Wang, H. Unruh, R.B. Light, D. Bose, T. Chau, E. Correa, and S. Mink. Hemofiltration
reverses left ventricular dysfunction during sepsis in dogs. Anesthesiology 73:671-685, 1990.
27.
Correa, E., S. Mink, H. Unruh, and W. Kepron. Left ventricular contractility is depressed in IgE mediated
anaphylactic shock in dogs. Am. J. Physiology 260 (Heart and Circulation 29):H744-751, 1991.
28.
Georgopoulos, D., S. Mink, L. Oppenheimer, and N. Anthonisen. How is maximal expiratory flow reduced
in canine post-pneumonectomy lung growth? J. Appl. Physiol. 71:834-840, 1991.
29.
Unruh, H. W., R. Wang, D. Bose, and S. Mink. Does pentobarbital anesthesia depress left ventricular
contractility in dogs? Am. J. Physiol 261 (Heart Circ. Physiol. 30):H700-H706, 1991.
30.
Gomez, A., and S. Mink. Interaction between effects of hypoxia and hypercapnia on altering left ventricular
relaxation and chamber stiffness in dogs. Am. Rev. Respir. Dis. 146: 313-320, 1992.
31.
Yu, J, A. Guia, S. Mink, W, Kepron, E. Cragoe, S. Sharma, and R Bose. Role of sodium in antigen -induced
contraction of tracheal smooth muscle in dogs. Respiration Physiology 91: 111-124, 1993.
32.
Jha, P, H Jacobs, D Bose, R Wang, J Yang, RB Light, S Mink. Effects of E. coli sepsis and myocardial
depressant factor on interval-force relations in dog ventricle. Am J Physiol 264 (Heart Circ Physiol 33):
H1402-H1410, 1993.
33.
Gomez, A., H. Unruh, and S. Mink. Altered left ventricular chamber stiffness and isovolumic relaxation in
11
Steven N. Mink, MD
dogs with chronic pulmonary hypertension caused by emphysema. Circulation 87: 247-260, 1993.
34.
Gomez, A., H. Unruh, and S. Mink. Left ventricular systolic function is depressed in chronic pulmonary
emphysema in dogs. Am J Physiol 267 (Heart Circ Physiol 36): H232-H247, 1994.
35.
Leblanc, P, Mink S, Keistinen T, Saarelainen PA, Ringdal N, Payne SL. A comparison of fluticasone
propionate 200 micrograms/day with beclomethasone dipropionate 400 micrograms/day in adult asthma.
Allergy 49: 380-385, 1994.
36.
Georgopoulos, D, A Gomez, S Mink. Factors determining lobar emptying rates during maximal and partial
forced deflations in nonhomogeneous airway obstruction in dogs. Am J Respir Dis 149: 1241-1247, 1994.
37.
Mink, S, P Jha, R Wang, J Yang, D Bose, H Jacobs, R Light. Effect of arteriovenous hemofiltration
combined with systemic vasopressor therapy on depressed left ventricular contractility and oxygen delivery in
canine E. coli sepsis. Anesthesiology 83: 178-190, 1995.
38.
Yu, J, S Mink. Activation of pulmonary rapidly adapting receptors does not induce bronchoconstriction in
dogs. J. Appl. Physiol. 80: 233-239, 1996.
39.
Mink, S. Mechanism of lobar alveolar pressure decline during forced expiration in canine regional
emphysema. J Appl Physiol. 82: 632-643, 1997.
40.
Mink, S N, A Becker, H Unruh, W Kepron. Effects of mediators of anaphylaxis on partitioned pulmonary
vascular resistance during ragweed shock in dogs. J Appl Physiol 84: 782-790, 1998.
41.
Gu, M, R Bose, D Bose, RB Light, R Wang, X Li, H Jacobs, S Mink. Tumour necrosis factor alpha, but not
septic plasma depresses cardiac myofilament contraction. Canadian J Anaesth 45:352-359, 1998.
42.
Mink, SN, C Bands, A. Becker, J Elkin, S. Sharma, H. Unruh, W. Kepron. Effect of bolus epinephrine on
systemic hemodynamics in canine anaphylactic shock. Cardiovascular Research 40:546-556, 1998.
43.
Li, X, G Eschun, D Bose, H Jacobs, JJ Yang, RB Light, SN Mink. Histamine H3 activation depresses cardiac
function in experimental sepsis. J Appl Physiol 85(5):1693-1701, 1998.
44.
Mink S, Sharma S, Becker A, Duke K, Unruh H, Kepron W. Role of autocoids in cardiovascular collapse in
anaphylactic shock in dogs. Cardiovascular Research 43: 173-182, 1999.
45.
Mink, S, X Li, D Bose, M Gu, G Lu, H Jacobs, RB Light. Early but not delayed continuous arteriovenous
hemofiltration improves cardiac function in sepsis in dogs. Intensive Care Medicine 25:733-743, 1999.
46.
Chrusch, C, S Sharma, H Unruh, E Bautista, K Duke, A Becker, W Kepron, SN Mink. Histamine H3 receptor
blockade improves cardiac function in canine anaphylaxis. Am J Respir Critical Care Medicine 160: 11421149, 2000.
47.
Chrusch, C, Bands C, Bose D, Li X, Jacobs H, Duke K, Bautista E, Light RB, Mink SN. Impaired hepatic
extraction and increased splanchnic production contribute to lactic acidosis in canine sepsis. Am J Respir
Crit Care Med 161:517-526, 2000.
48.
Tan L A, H Unruh, S N Mink. Volume Reduction Surgery for the Treatment of Severe Emphysema. : A
study in a single Canadian Institution. Canadian Journal of Surgery 43: 369-376, 2000.
49.
Patel D, K Duke, RB Light, H Jacobs, SN Mink, D Bose. Impaired sarcoplasmic calcium release inhibits
myocardial contraction in experimental sepsis. Impaired sarcoplasmic calcium release inhibits myocardial
contraction in experimental sepsis Journal Crit Care 15: 64-72, 2000.
12
Steven N. Mink, MD
50.
Ewing-Bui, DT, SN Mink. Interdependence of flow between lobes reduces maximal emptying post-resection
in dogs. J Appl Physiol. 92: 1008, 2002.
51.
Eschun G, E Bautista, K Duke, SN Mink. Effect of histamine H3 receptor blockade on venous return and
splanchnic hemodynamics in sepsis. Critical Care Medicine 30:628-636, 2002.
52.
Bautista E, FER Simons, KJ Simons, AB Becker, K Duke, M Tillett, SN Mink. Epinephrine fails to hasten
hemodynamic recovery in fully developed canine anaphylactic shock. International Archives of Allergy and
Immunology 128: 151-164, 2002.
53.
Cheng Z, Bose D, Jacobs H, Light RB, Mink SN. Sepsis causes presynaptic histamine H3 and alpha2
adrenergic dysfunction in canine myocardium. Cardiovascular Research 56: 225-34, 2002.
54.
Eschun G, SN Mink, Sat Sharma. Pulmonary interstitial fibrosis as a presenting manifestation in p-ANCA
microscopic polyangiitis. Chest 123: 297-301, 2003.
55.
Chidambaram M, Mink S, Sharma S. Artial septal aneurysm with right to left interarterial shunting. Tex
Heart Inst J 30:68-70, 2003.
56
Mink SN, Jacobs H, Bose D, Duke K, Cheng Z, Liu G, Light RB. Lysozyme: a mediator of myocardial
depression and adenergic dysfunction in septic shock in dogs. J Mol Cell Cardiol 35: 265-275,2003.
57
Mink SN, Jacobs H, Bose D, Duke, Cheng Z, Light RB. N,N’,N” triacetylglucosamine, an inhibitor of
lysozyme, prevents myocardial depression in E coli sepsis in dogs. Crit Care Med 2004; 32:184-193.
58.
Mink SN, Gonzalez X, Duke K, Bautista E, Tan L. Advantages of a new surgical system used for lung
volume reduction surgery in a canine model of predominantly upper lobe emphysema. Chest 2004; 125:633643.
59.
Fitzgerald JM, Becker AB, Sears M, Mink SN, Chung K, Math JL, and the Canadian Asthma Exacerbation
Study Group. Doubling the dose of budesonide versus maintenance therapy in asthma exacerbations. Thorax
2004; 59: 550-556.
60.
Mink SN, Simons FER, Simons KJ, Becker AB, Duke K. Constant infusion of epinephrine, but not bolus
treatment, improves hemodynamic recovery in anaphylactic shock in dogs. Clinical and Experimental
Allergy 2004; 34:1776-1783.
61.
Jacobs H, Mink SN, Duke K, Bose D, Cheng ZQ, Howlett S, Ferrier G, Light RB. Characterization of
surface membrane N-glycan binding sites of lysozyme for myocardial depression in sepsis. Intensive Care
Medicine 2005; 31:129-137.
62.
Mink SN, Bose R, Roberts DE, Jacobs H, Duke K, Bose D, Cheng ZQ, Light RB. Lysozyme binding to
endocardial endothelium mediates myocardial depression by the nitric-oxide guanosine 3’,5’
monophosphate pathway in sepsis. J Mol Cell Cardiol 2005; 39: 615-625.
63.
Buduhan G, Tan, Kasian K, Mink SN. Volume reduction surgery impairs immediate post-operative
pulmonary function in canine emphysema. Am J Respir Crit Care Med 174:1310-1318, 2006.
64.
Mink SN, Kasian K, Jacobs J, Cheng ZQ, Light RB. N,N’ – diacetylchitobiose, an inhibitor of lysozyme,
reverses myocardial depression and lessens norepinephrine requirements in Escherichia coli sepsis in dogs.
Shock 29: 681-687, 2008 ( 2007 Sep 20; [Epub ahead of print]
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Steven N. Mink, MD
65
Mink SN, Zhao-Qin Cheng, Bose R, Jacobs H, Kasian K, Roberts DE, Light RB. Lysozyme, a mediator of
sepsis, impairs cardiac adrenergic response by non-endothelial release of nitric oxide and inhibitory G
protein signaling. Am J Physiol Heart Circ Physiol 293: 3140-3149, 2007.
66.
Mink SN, Kasian, K, Santos-Martinez LE, Bose R, Cheng ZQ, Jacobs H, Bose R, Jacobs J, Light RB.
Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial
preparation. Am J Physiol Heart and Circ Physiol 294: H1724-H1735, 2008 [2008 Feb 8; [Epub ahead of
print].
67.
Mink SN, Jacobs H, Cheng ZQ, Kasian K, Santos-Martinez LE, Light RB. Lysozyme, a mediator of sepsis
that intrinsically generates hydrogen peroxide to cause cardiovascular collapse. Am J Physiol Heart and
Circ Physiol 297: H930-H938, 2009 [2009 Jun 19. pub ahead of print]
68).
Mink SN, Jacobs, H, Gotes J, H, Kasian K, Cheng ZQ. Ethyl-gallate, a scavenger of hydrogen peroxide that
inhibits hydrogen- peroxide signaling in vitro, reverses hypotension in canine septic shock. J Appl Physiol
110: 359-374, 2011.
69).
Gotes, J, Jacobs, Kasian K, Cheng ZQ, Mink SN. Benefits of ethyl gallate vs norepinephrine in the
treatment cardiovascular collapse in Pseudomonas aeruginosa septic shock in dogs. Crit Care Med. 2011
Oct 20. [Epub ahead of print]
70).
Gotes J, Kasian K, Jacobs H, Cheng ZQ, Mink SN. Mechanisms of systemic vasodilation by lysozyme-c in
septic shock. J Appl Physiol. 2011 Nov 17. [Epub ahead of print].
71).
Mink SN, Maycher B. Comparative manifestations and diagnostic accuracy of high-resolution computed
tomography in usual interstitial pneumonia and nonspecific interstitial pneumonia. Curr Opin Pulm Med 18:
530-534, 2012.
72).
Gotes J, Kasian K, Jacobs H, Cheng ZQ, Mink SN. Lysozyme, a mediator of sepsis that deposits in the
systemic vaculature and kidney as a mechanism of acute organ dysfunction. Shock. 41(3):256-65, 2014.
73).
Mink SN, Chowdhury SKR, Gotes J, Cheng ZQ, Krika K, Fernyhough P. Gentisic acid sodium salt, a
phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic
mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs. Submitted
to Shock.
IV. Contributed Papers in Published Conference Proceedings and Abstracts
1.
Mink, S.N. and L.D.H. Wood. Site and mechanism of HeO2 enhanced expiratory flow. Clin. Res., 25:714A,
1977.
2.
Mink, S.N. and L.D.H. Wood. Effect of gas density on expiratory flow limitation in dogs. Fed. Proc.,
37:553, 1978.
3.
Mink, S.N. and L.D.H. Wood. How does HeO2 cause increased maximum expiratory flow in excised human
lungs? Am. Rev. Respir. Dis., 117:375, 1978.
4.
Light, R.B., S.N. Mink, and L.D.H. Wood. Pathophysiology of hypoxemia in bacterial pneumonia. Clin.
Res., 26:879A, 1978.
5.
Light, R.B., S.N. Mink, and L.D.H. Wood. Pathophysiology of hypoxemia and reduced lung volumes in
bacterial pneumonia. Am. Rev. Respir. Dis., 119:143, 1979.
14
Steven N. Mink, MD
6.
Mink, S.N., B. Light, and L.D.H. Wood. Lung mechanics in canine diplococcal pneumonia. Fed. Proc.,
38:1331, 1979.
7.
Mink, S.N., B. Light and L.D.H. Wood. Effect of PEEP in canine lobar pneumonia. Physiologist, 22:89,
1979.
8.
Light, R.B., T.G. Cooligan, K. Duke, L.D.H. Wood, and S.N. Mink. Physiology of recovery in canine lobar
pneumonia. Am. Rev. Respir. Dis., 121:122, 1980.
9.
Cooligan, T.G., R. Light, K. Duke, L.D.H. Wood, and S.N. Mink. The effect of volume infusion in canine
lobar pneumonia. Am. Rev. Respir. Dis., 121:122, 1980.
10.
Light, R.B., S.N. Mink, and L.D.H. Wood. Unilateral positive end expiratory pressure (PEEP) in canine
pneumococcal lobar pneumonia. Clin. Res., 28:702A, 1980.
11.
Mink, S.N. and L.D.H. Wood. "Choke-point" movement during forced vital capacity deflation in dogs.
Physiologist 23:121, 1980.
12.
Mink, S.N., J.R. Holcomb, K. Terrell, and W.G. Johanson, Jr. Sequential changes in lung mechanics in a
model of diffuse alveolar damage. Clin. Res., 28:702A, 1980.
13.
Mink, S.N. and L.D.H. Wood. The effect of increased lung elastic recoil (PEL) and decreased airway
resistance (RL) on "choke point" movement in dogs. Fed. Proc., 40:2091, 1981.
14.
Mink, S.N. The effect of methacholine induced bronchoconstriction on the airway site of flow limitation in
dogs. Physiologist, 23:29, 1981.
15.
Mink, S.N. Mechanism of reduced density dependence of maximum expiratory flow (Vmax) during
methacholine-induced broncho-constriction in dogs. Fed. Proc., 41:1356, 1982.
16.
Whitley, L.G., J.J. Coalson, and S.N. Mink. Bronchiolitis obliterans in a canine model: changes in lung
mechanics and an assessment of tests of peripheral airway function. Am. Rev. Respir. Dis., 125(4):189,
1982.
17.
Mink, S.N. Mechanism of reduced maximum expiratory flow (Vmax) in a canine model of pulmonary
emphysema (PE). Fed. Proc., 42:1008, 1983.
18.
Pyszczynski, D., S.N. Mink, and N.R. Anthonisen. Effect of increased gravitational stress on maximum
expiratory flow-volume curve. Fed. Proc., 42:1009, 1983.
19.
Mink, S.N., L. Whitley and J. Coalson. Hemodynamics in a canine model of pulmonary emphysema: their
relationship to lung mechanics and gas exchange. Am. Rev. Respir. Dis., 127(4):116, 1983.
20.
Jadue, C., H.W. Greville, and S.N. Mink. Mechanism of reduced maximum expiratory flow (Vmax) in a
canine model of bronchiolitis obliterans (BN). Fed. Proc., 43:435, 1984.
21.
Greville, H.W., M.E. Arnup, S.N. Mink, L. Oppenheimer, and N.R. Anthonisen. Maximum expiratory flow
(Vmax) reduction in pneumonectomized dogs. Fed. Proc., 43:435, 1984.
22.
Light, R.B. and S.N. Mink. Distribution of systemic blood flow in experimental gram-negative bacteremia.
Am. Rev. Respir. Dis., 129(4):A98, 1984.
23.
Greville, H.W. and S.N. Mink. Variability in the response to breathing 80:20 helium-oxygen at different lung
volumes in induced bronchoconstriction in dogs. Am. Rev. Respir. Dis., 129(4):A249, 1984.
15
Steven N. Mink, MD
24.
Jadue, C., H.W. Greville, and S.N. Mink. Mechanism of preserved density-dependence of maximum
expiratory flow in a canine model of peripheral airways disease. Am. Rev. Respir. Dis., 129(4):A257, 1984.
25.
Mink, S.N., H. Unruh, and L. Oppenheimer. Vascular and interstitial mechanics in canine pulmonary
emphysema. Am. Rev. Respir. Dis., 129(4):A330, 1984.
26.
Light, R.B. and S.N. Mink. Distribution of systemic blood-flow in experimental gram negative bacteremia.
Am. Rev. Respir. Dis., 129:249, 1984.
27.
Gomez, A and S.N. Mink. Right ventricular performance during acute hypoxic hypoxia in dogs. Am. Rev.
Respir. Dis., 131(4):57, 1985.
28.
Gomez, A., K. Duke and S.N. Mink. Effect of hypoxic hypoxia on left ventricular mechanics in dogs with
pulmonary emphysema. Am. Rev. Respir. Dis., 131(4):57, 1985.
29.
Greville, H.W., A. Gomez and S.N. Mink. Expiratory flow limitation in dogs which nonhomogeneous airway
obstruction is produced. Fed. Proc., 44:838, 1985.
30.
Mink, S.N. and H. Greville. Forced expiration in a canine model of non-uniform airflow obstruction. Fed.
Proc., 45:314, 1986.
31.
Gomez, A., J. Eng, and S.N. Mink. Effect of aminophylline on hypoxia induced decrease in ventricular
diastolic compliance in dogs. Am. Rev. Respir. Dis., 133:A302, 1986.
32.
Gomez, A., H. Unruh, and S.N. Mink. Left ventricular end-systolic pressure dimension relations in awake
and anesthetized dogs. Am. Rev. Respir. Dis., 135:113, 1987.
33.
Gomez, A. and S.N. Mink. Effect of acute respiratory acidosis on hypoxia-induced increase in ventricular
diastolic stiffness in dogs. Am. Rev. Respir. Dis., 135:113, 1987.
34.
Mink, S., Gomez, A., and J. Eng. Effect of inhaled atropine on maximum expiratory flow (Vmax) in dogs.
Fed. Proc. 46:512, 1987.
35.
Gomez, A., H. Unruh, R.B. Light, D. Bose, T. Chau, J. Eng, and S. Mink. Hemofiltration reverses left
ventricular systolic dysfunction during E-coli bacteremia in dogs. Am. Rev. Respir. Dis., 137:114, 1988.
36.
Mink, S., A. Gomez, H. Unruh, and J. Eng. Stroke-volume is reduced in dogs with chronic but not acute
emphysema. Am. Rev. Respir. Dis., 137:471, 1988.
37.
Mink, S., A. Gomez, R.B. Light, H. Unruh, and J. Eng. How does afterload reduction with hydralazine
increase stroke-volume in dogs? Am. Rev. Respir. Dis., 137:139, 1988.
38.
Anthonisen, N.R., S.G. Holtby, D. Berezanski, and S.N. Mink. Inhomogeneity of lobar emptying after postpneumonectomy lung growth. FASEB Abstract, 2:A1698, 1988.
39.
Holtby, S., D. Georgopoulos, A. Gomez, L. Oppenheimer, D. Berezanski, N.R. Anthonisen, and S. Mink.
Non-homogeneity of lobar emptying during forced deflation in a canine model of compensatory lung growth.
FASEB 3:1302, 1989.
40.
Mink, S., D. Georgopoulos, A. Gomez, and J. Eng. Lobar emptying during partial and vital capacity forced
deflation in non-homogenous airflow obstruction in dogs. FASEB 3:1302, 1989.
41.
Eng, J., W. Ruining, A. Gomez, H. Jacobs, D. Bose, T. Chau, H. Unruh, R.B. Light, and S. Mink.
Myocardial depressant factor is found in the 10,000 to 30,000 molecular weight fraction of plasma in E. coli
septic shock in dogs. Am Rev Respir Dis 139:19, 1989.
16
Steven N. Mink, MD
42.
Gomez, A., J. Eng, R. Bose, I. Krampetz, and S. Mink. Amiloride potentiates hypoxia-induced left
ventricular stiffness in dogs. Am Rev Respir Dis 139:21, 1989.
43.
Correa, E., A. Gomez, H. Unruh, J. Eng, S. Mink, and W. Kepron. Left ventricular systolic performance is
depressed in IgE mediated anaphylactic shock in dogs. Am Rev Respir Dis 139:21, 1989.
44.
Gomez, A., J. Eng, H. Unruh, and S. Mink. Altered left ventricular isovolumic relaxation accompanies
stroke-volume reduction after one year of pulmonary emphysema in dogs. Am Rev Respir Dis 139:120,
1989.
45.
Georgopoulos, D., L. Oppenheimer, N.R. Anthonisen, and S. Mink. How is maximal expiratory flow (Vmax)
reduced in postpneumonectomy (PP) lung growth in dogs? FASEB, 4:A288, 1990.
46.
Yu, J., R. Bose, S. Mink, W. Kepron, and E.J. Cragoe. Mechanism of blocking effect of amiloride on
ragweed-induced tracheal smooth muscle contraction in dogs. FASEB, 4:A614, 1990.
47.
Wang, R., H. Jacobs, D. Bose, T. Chau, H. Unruh, R. Light, and S. Mink. Analysis of biochemical nature of
myocardial depressant factor (MDF) in E. coli sepsis in dogs. Am. Rev. Respir. Dis. 141:139A, 1990.
48.
Mink, S. and A. Gomez. Increased left ventricular (LV) diastolic stiffness and decreased emptying occur
after 1 year of pulmonary emphysema in dogs. Am. Rev. Respir. Dis., 141:43A, 1990.
49.
Correa, E., H. Unruh, S. Mink, and W. Kepron. Reduced myocardial blood flow does not contribute to
depressed left ventricular contractility in anaphylactic shock in dogs. Am. Rev. Respir. Dis., 141:774A,
1990.
50.
Kepron, W., E. Correa, H. Unruh, K. Duke, and S. Mink. Different effects of blockers of mediators of
anaphylaxis on cardiac hemodynamics during ragweed challenge in dogs. Am. Rev. Respir. Dis.,
143(4):A779, 1991.
51.
Georgopoulos, D., S. Mink, L. Oppenheimer, and N. R. Anthonisen. Increased lobar frictional resistance and
altered dynamic properties of central airways reduce maximum expiratory flow in canine postpneumonectomy lung growth. Am. Rev. Respir. Dis., 143(4):A353, 1991.
52.
Jha, P., R. Wang, R.B. Light, R. Bouchard, D. Bose, H. Jacobs, and S. Mink. Sarcoplasmic reticulum
calcium release is not depressed in E. coli sepsis in dogs. Am. Rev. Respir. Dis., 143(4):A683, 1991.
53.
Mink, S., H. Unruh, and A. Gomez. Mechanism of increased left ventricular fractional shortening during
systemic afterload reduction in conscious dogs. Am. Rev. Respir. Dis., 143(4):A245, 1991.
54.
Jha, P, R Wang, J Yang, D Bose, H Jacobs, H Unruh, S N Mink, RB Light. Phenylephrine infusion combined
with arteriovenous hemofiltration improves stroke-volume during sepsis in dogs. Am Rev Respir Dis
145:A316, 1992.
55.
Wang, R, J Yang, H Jacobs, D Bose, RB Light, S Mink. Biochemical characterization of filterable
cardiodepressant substance in canine E.coli sepsis. Am Rev Respir Dis 145:A315, 1992.
56.
Wang R, Yang J, Jacobs H, Bose D, Light RB, Mink S. Characterization of filterable cardiodepressant
substance by isoelectric focusing techniques in canine E. coli sepsis. Am Rev Respir Dis 147:A102, 1993.
57.
Sharma S, W Kepron, H Unruh, K Duke , S Mink. Histamine H1 receptor blockade prevents myocardial
depression in IgE mediated canine anaphylaxis. Am Rev Respir Dis 147:A613, 1993.
58.
Mink, S. Lobar interaction during maximal deflation in dogs with unilateral emphysema. Am J Respir Crit
17
Steven N. Mink, MD
Care Med 149:A225, 1994.
59.
Yang, J, R Wang, H Jacobs, D Bose, R B Light, S N Mink. Purification of filterable cardiodepressant
substance by high pressure liquid chromatography techniques in canine E. coli sepsis. Am J Respir Crit Care
Med 149:A657, 1994.
60.
Elkin, J, K Duke, G Price, W Kepron, A Becker, S Mink. Does bolus epinephrine improve systemic
hemodynamics during anaphylactic shock in dogs? Am J Respir Crit Care Med 149:A1060, 1994.
61.
Mink, S. Relative effects of ventricular interdependence and alveolar hypoxia on causing an increase in left
ventricular chamber stiffness in dogs. Am J Respir Crit Care Med 149:A1063, 1994.
62.
Yu, J, and S Mink. Do rapidly adapting receptors induce airway constriction? Proceeding of Third Congress
of Federation of Asian and Oceanian Physiological Societies. p 196 G2-9 (O), 1994.
63.
J Rosenberg and S Mink. Distribution of alveolar pressures during positive pressure ventilation in dogs with
nonhomogeneous airflow obstruction. Am J Respir Crit Care Med 151: A551, 1995.
64.
Yu, J, and S Mink. Role of rapidly adapting receptors in airway constriction. Am J Respir Crit Care Med
151: A825, 1995.
65.
Elkin, J, A Becker, W Kepron, K Duke, G Price, S N Mink. Bolus-epinephrine treatment impairs cardiac
hemodynamics in canine anaphylactic shock. Am J Respir Crit Care Med 151: A708, 1995.
66.
X. Li, J. Yang, H. Jacobs, D. Bose, R.B. Light, S.N. Mink. Myocardial depressant activity is found in the
heart and spleen as well as in plasma of dogs subjected to E. Coli sepsis. Am J Respir Crit Care Med 153:
A833, 1996.
67.
Bands, C., H. Jacobs, D. Bose, K. Duke, G. Price, R.B. Light, S.N. Mink. Effect of norepinephrine on
hepatic blood flow and lactate metabolism in E. coli shock in dogs. Am J Respir Crit Care Medicine 153:
A464, 1996.
68.
Bands, C., A. Becker, H. Unruh, W. Kepron, K. Duke, G. Price, S.N. Mink. Bolus epinephrine impairs left
ventricular systolic function in canine anaphylactic Shock. Am J Respir Crit Care Medicine 153: A468,
1996.
69.
Mink, S N, A Becker, S Sharma, H Unruh, W Kepron. Myocardial depression is not reversed by histamine
H1, H2 receptor blockade or eicosanoid inhibition during ragweed challenge in dogs. Am J Respir Crit Care
Medicine 702, 1997.
70.
Mink, S, X Li, J Yang, K Duke, D Bose, H Jacobs, R B light. Histamine H3 receptor blockade improves
cardiac output in E coli sepsis in dogs. Am J Respir Crit Care Medicine 155: 702A, 1997.
71.
Bands, C, H Jacobs, D Bose, K Duke, R B Light, X Li, J Yang, S N Mink. Modulation of hepatic blood flow
by vasopressors fails to improve hepatic lactate metabolism in E coli septic shock in dogs. Am J. Respir Crit
Care Medicine 155: 702A, 1997.
72.
Mink, S.N. A. Becker, H. Unruh, W. Kepron. Effects of mediators of anaphylaxis on partitioned pulmonary
vascular resistance during ragweed shock in dogs. Am J Respir Crit Care Medicine 155: 702A, 1997.
73.
Eschun, G., X Li, J. Yang, D. Bose, H. Jacobs, RB Light, S. Mink. Histamine H3 receptor blockade
improves left ventricular contractility in E. coli sepsis in dogs. Am J Respir Crit Care Med 157:A689, 1998.
74.
Chrusch, C., W. Kepron, H. Unruh, SN Mink. Comparative effects of histamine H1, H2, H3, receptor
blockade on left ventricular systolic performance in anaphylactic shock in dogs. Am J Respir Crit Care Med
18
22
Steven N. Mink, MD
157:A102,1998.
75.
Bautista, E., A. Becker, K. Duke, M. Tillet, E. Simons, K. Simons, S. Mink, W. Kepron. Effects of different
routes of epinephrine administration on hemodynamic recovery in anaphylactic shock in dogs. Am J Respir
Crit Care Med: 159, 520A, 1999.
76.
Li, X., D. Bose, RB Light, H. Jacobs, SN Mink. Interaction between Histamine H3 Receptors and 2
Adrenoceptors on modulating myocardial function in experimental sepsis. Am J Respir Crit Care Med: 159,
246A, 1999.
77.
Chrusch, C, E Bautista, G Eschun, K Duke, SN Mink. Lactate metabolism during acute hyperlactatemia in E
coli septic shock in dogs. Am J Respir Crit Care Med 159, 614A, 1999.
78.
Bautista, E, A Becker, K Duke, E Simons, K Simons, S Mink, W Kepron. Limited utility of intramuscular
epinephrine in the treatment of hemodynamic collapse in experimental anaphylactic shock. Am J Respir Crit
Care Med: 161: A549, 2000.
79.
Chrusch, C, E Bautista, G Eschun, K Duke, SN Mink. PH dependence of organ metabolism of lactate in
septic and nonsseptic dogs. Am J Respir Crit Care Med: 161: A879, 2000.
80.
Eschun, G, E Bautista, K Duke, SN Mink. Effect of histamine H3 receptor blockade on venous return and
splanchnic hemodynamics in sepsis. Am J Respir Crit Care Med: 161: A885, 2000.
81.
Bautista E, K Duke, A Becker, E Simons, K Simons, W Kepron, SN Mink. Effects of repetitive allergen
challenges on hemodynamics and epinephrine response in anaphylactic shock in dogs. Am J Respir Crit Care
Med: 163: A136, 2001.
82.
Chrusch C, E Bautista, G Eschun, K Duke, SN Mink. Effect of sodium acetate infusion on lactate
metabolism in septic shock in dogs. Am J Respir Crit Care Med: 163: A456, 2001.
83.
Mink SN, Gonzalez X, Krika Duke, EG Bautisa, L Tan. Development of a canine model of upper lobe
emphysema used for the evaluation of a novel implantable device for lung volume reduction surgery. Chest
120: 157S, 2001.
84.
Mink SN, D Bose, Z Cheng, H Jacobs, RB Light, K Duke. Lysozyme reduces the cardiac response to neural
sympathetic stimulation in dogs. Am J Respir Crit Care Med 165: 172, 2002.
85.
Z Cheng, D Bose, H Jacobs, RB Light, K Duke, SN Mink. Septic plasma attenuates the cardiac response to
neural sympathetic stimulation in dogs. Am J Respir Crit Care Med 165: 172, 2002.
86.
SN Mink, A Becker, K Duke, M Tillett, E Simons, K Simons, W Kepron. Early administration of bolus
epinephrine fails to improve cardiovascular collapse in ragweed sensitized dogs. Am J Respir Crit Care Med
165:B29 ,2002.
87.
SN Mink, X Gonzalez, K Duke, E Bautista, L Tan. Six-month evaluation of a novel implantable device for
lung volume reduction surgery in a canine model of upper lobe emphysema. Am J Respir Crit Care Med 165:
B12, 2002.
88.
Mink SN, Z Cheng, D Bose, H Jacobs, K Duke, RB Light. Sepsis causes presynaptic histamine H3 and
alpha2 adrenergic dysfunction in canine myocardium. Am J Respir Crit Care Med 167: A550, 2003.
89.
Mink SN, Dillard DH, Gonzalez X, Strokeman WA, Park M, Duke K, De Vore L. Lung volume reduction
produced by a removable intrabronchial value in dogs. Chest 124:124S, 2003.
90.
Gonzalez, A, Park M, Dillard DH, Strokeman WA, Y S, Coutetil LL, Mink SN. Reliability of an intra-
22
Steven N. Mink, MD
bronchial valve anchoring method in a six-month animal study. Chest 124, 142S, 2003.
91.
Mink SN, Jacobs H, Duke K, Bose D, Cheng Z, Light RB. N,N’,N” triaceytlcuosamine, an inhibitor of
lysozyme prevents myocardial depression in E coli sepsis in dogs. Am J Respir Crit Med 2004; 169: 633.
92.
SN Mink, H Jacobs K Duke, D Bose, ZQ Cheng, S Howlett, G Ferrier, RB Light. Characterization of
surface membrane N-glycan binding sites of lysozyme for myocardial depression in sepsis. Am J Respir
Crit Care Med 2005; 171: 40.
93.
SN Mink, H Jacobs, R Bose, K Duke, D Bose, ZQ Cheng, RB Light. Lysozyme binding to endocardial
endothelium mediates myocardial depression by the nitric-oxide guanosine 3’,5’ monophosphate pathway in
sepsis. Am J Respir Crit Care Med 2005; 171: 40.
94.
Mink SN, Bose D, Jacobs H, Bose R, Chenq ZQ, Duke K, Light RB. Lysozyme mediates cardiac adrenergic
dysfunction by activation of the β3 adrenoreceptor in sepsis. Proceedings of the Am Thorac Soc 3:A648,
2006
95).
Mink SN, Kasian K, Jacobs J, Cheng ZQ, Light RB. N,N’ – diacetylchitobiose, an inhibitor of lysozyme,
reverses myocardial depression and lessens norepinephrine requirements in Escherichia coli sepsis in dogs.
Am J Respir Crit Care Med 2007: 175 A32.
96).
Mink SN, Kasian, K, Santos-Martinez LE, Bose R, Cheng ZQ, Jacobs H, Bose R, Jacobs J, Light RB.
Lysozyme, a mediator of vasodilation in sepsis that can be inhibited by a peroxidase and hydroxyl radical
scavengers. Am J Respir Crit Care Med 2008; 177: 577.
97).
Mink SN, Jacobs H, Cheng ZQ, Kasian K, Santos-Martinez LE, Light RB. Lysozyme, a mediator of
inflammation, spontaneously causes the release of hydrogen peroxide to cause myocardial dysfunction in
experimental septic shock. Am J Respir Crit Care Med 2009; 179: 577.
98).
Gotes J, Jacobs H , Kasian K, Cheng ZQ, SN Mink. Hydroperoxides produce vasodilation by activiation of
cyclooxygense and potassium channels in the carotid artery of dogs. Am J Respir Crit Care Med 181:
A1134, 2010.
99).
Mink, SN, Jacobs H, Gotes J Kasian K, Cheng Z.Q. Ethyl-gallate, a new treatment of cardiovascular
collapse in experimental septic shock. Am J Respir Crit Care Med 181: A6160, 2010.
100).
Gotes, J, Jacobs, Kasian K, Cheng ZQ, Mink SN. Benefits of ethyl gallate vs norepinephrine in the
treatment cardiovascular collapse in Pseudomonas aeruginosa septic shock in dogs. Am J Respir Crit Care
Med 183: A3864, 2011.
101).
Gotes J, Jacobs H , Kasian K, Cheng ZQ, Mink SN. Lysozyme-C Accumulates Within The Vascular
Smooth Muscle Layer To Produce Vasodilation In Canine Septic Shock. Am J Respir Crit Care Med
185;A60)6, 2012.
102).
Gotes J, Jacobs H , Kasian K, Cheng ZQ, Mink SN. Lysozyme-c, a mediator of sepsis that can accumulate
in the vasculature and kidney tubules leading to systemic vasodilation and activation of renal-inflammatory
pathways. Am J Respir Crit Care Med 187: A3039, 2013.
103).
Mink SN, Chowdhury SR, Cheng ZQ, Kasian K, Fernyhough P. Hepatic Mitochochondrial Bioenergetics
Are Impaired In A Canine Model Of Septic Shock. Am J Respir Crit Care Med 189: A1648, 2014.
104).
Mink SN, Chowdhury SKR, Gotes J, Cheng ZQ, Kasian K, Fernyhough P. Gentisic Acid Sodium Salt, A
Phenolic Compound, Is Superior To Norepinephrine In Reversing Cardiovascular Collapse, Hepatic
Mitochondrial Dysfunction And Lactic Acidemia In Pseudomonas Aeruginosa Septic Shock In Dogs
Am J Crit Care Med 191: A2547, 2015.
23
Steven N. Mink, MD
V. Books, and Chapters in Books.
A Simplified Approach to the Management of Patients with Respiratory Disorders (Computer Program).
Mayer Zev Enterprises, LTD. Winnipeg, Manitoba; 1st edition 98, 2nd edition 2002.
VI.
Patents Awarded
US Patent 8,772,339 B2. Awarded July 8, 2014. Ethyl gallate and related compounds as a treatment for sepsis and
septic shock. The use ofe thyl gallate, methyl gallate or 3,4 dihydroxybenzoate may also prophylactically treat septic
shock via administration to subject before the development of a fall in blood pressure.
Canadian Patent 2,428,744 awarded June 25, 2013. Inhibition of lysozyme in treating sepsis-induced myocardial
dysfunction . Methods and compositions for treating myocardial dysfunction are described. The methods of the
invention involve administering an agent that can inhibit lysozyme to an animal in need thereof. Preferred lysozyme
inhibitions include chitobiose and chitotriose.
US Patent 7402575 (US patent 7,402,575B2 and CA2428744AA). “Methods of treating inflammation”, which
teaches methods and compositions methods and compositions for treating myocardial dysfunction or inflammation
involving administering an agent that can inhibit lysozyme to an animal or human in need thereof, preferred
inhibitors include TAC and chitobiose. This patent covers the basic technology, a method of developing new
compounds.
VII.
Patents under consideration
(PCT CA/2010/000221) “Ethyl gallate and related compounds as treatments for sepsis and septic shock”, which
teaches the use of related molecules to treat hypotension.
(PCT/CA2006/001662) “an inflammatory mediator of cardiac adrenergic dysfunction”. Methods and
compositions for treating adrenergic dysfunction by inhibiting the effect of lysozyme-c on the nitric oxide/cyclic
guanosine 3’,5’monophosphate pathway in order to prevent cardiovascular collapse in septic shock.
(PCT/CA2008/001513; filing date 28 Aug. 2008) “A method of reducing a vasodilatory response using a
guanylate cylcase pathway inhibitor or an H2O2 reducing agent”.
VIII.
Patents also submitted
Gentisic acid to treat septic shock.
24