Columbia University Medical Center Know Your Kangaroo Joan M. Lakoski, PhD • Robert J. Milner, PhD

ColumbiaUniversityMedicalCenter
KnowYourKangaroo
JoanM.Lakoski,PhD•RobertJ.Milner,PhD
K99/R00:PathwaytoIndependenceAward
—tofacilitateindependentfunding
earlierinaninves3gator’scareer
• forhighlypromising
postdoctoralscienDsts
• establishedinresponseto
increasingageoffirst
independentsupport
• non-ciDzensareeligible
BUT,firstmajorindependentresearchsupport
occursatanever-laterage
October30,2015
Goaloftraining&careerdevelopmentawardsis
researchindependence
student
F31
F30
postdoc
resident
F32
junior
faculty
senior
faculty
KAwards
Research independence is
demonstrated by obtaining
research project grants
R01
TheK99/R00Awardwasestablishedtofacilitatethe
transiJontoindependence
PurposeofAward:
tofacilitateaDmelytransiDonofoutstanding
postdoctoralresearchersfrommentored,
postdoctoralresearchposiDonstoindependent,
tenure-trackorequivalentfacultyposiDons,and
to...helptheseindividualslaunchcompeDDve,
independentresearchcareers.*
postdoc
resident
http://grants.nih.gov/grants/20040712_New_Investigator_Talk.ppt
K99/R00Awardscombineelements
ofKandR(research)awards
student
F31
F30
postdoc
resident
F32
junior
faculty
* K99/R00 Program Announcement (PA-14-042)
http://grants.nih.gov/grants/guide/pa-files/PA-14-042.html
K99/R00Awardsprovideupto
fiveyearsofsupportintwophases
junior
faculty
senior
faculty
KAwards
K99/R00
Award
K99Phase:
1-2yearsofmentoredsupportfor
highlypromisingpostdoctoral
researchscienDsts
R00Phase:
Upto3yearsofsupportconDngent
onsecuringanindependent
researchposiDon
postdoc
resident
junior
faculty
R01
©2015RobertJ.Milner,Ph.D.&JoanM.Lakoski,Ph.D.
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EligibilityforK99/R00Awards
Doctoraldegree(PhDorMD),withnomorethan
4years*postdoctoralresearchtraining
PostdocsinmentoredposiDonswhodonothavethe
abilitytobeindependentresearchers,i.e.,
•  individualswhohavenotheldanindependent
researchposiDon
•  orbeenPIonNIHresearch(R01,R03,R21)
orcareerdevelopment(K)awards
Mentored(K99)Phase
provides1–2yearsofmentoredsupport
ForhighlypromisingpostdoctoralresearchscienDsts
whohaveclinicalorresearchdoctorates
TrainingmaybeatNIHorextramuralinsDtuDons
butnotatforeigninsDtuDons
Totalcostperyearupto$90,000
(levelofsupportvariesbyI/C*)
includessalary&researchsupport
Commitmentof75%effort
U.S.ciDzensandnon-U.S.ciDzensareeligible
*newcriteriaeffec3veFebruary,2014
IndependentInvesIgator(R00)Phase
providesupto3yearsofsupport
*seeK99/R00TableofInsDtuteandCenterContacts
hbp://grants.nih.gov/grants/guide/contacts/parent_K99_R00.html
SuccessRatesforNIHK99/R00Awards
ToconductresearchasanindependentscienDst
ConDngentonacceptanceofatenure-track,fullDme
assistantprofessorposiDon(orequivalent)
•  FederalorforeigninsDtuDonsnoteligible
•  transiDonissubjecttoadministraDvereviewof
progressandevaluaDonofresearchplan
•  insDtuDonmustdemonstratecommitmentto
candidate(minimum75%effort,space)
Fundingupto$249,000totalcostsperyear,including
salary,researchsupport,indirectcosts
NumbersofK99/R00awardsvarybyNIHinsItute:
—2014awards
2007
2008
2009
2010
2011
2012
2013
2014
Total
Proposals
SubmiWed
Grants
Awarded
Success
Rate
893
795
703
778
832
911
926
1,118
6,956
183
180
204
194
180
212
203
247
1,603
20.5%
22.6%
29.0%
24.9%
21.6%
23.3%
21.9%
22.1%
23.0%
K99successratesvaryacrossNIHInsItutes
NIHaverage=22.1%
Datafrom:hbp://report.nih.gov/FileLink.aspx?rid=551
©2015RobertJ.Milner,Ph.D.&JoanM.Lakoski,Ph.D.
FY2014data:hbp://report.nih.gov/DisplayRePORT.aspx?rid=551
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AverageageofK99/R00recipientis34
K99/R00recipient
hbp://grants.nih.gov/grants/20040712_New_InvesDgator_Talk.ppt
ForQuesIons&AnswersaboutK99/R00Awards
K99/R00ContactsatNIH
Contact your Program Officer!!
K99/R00 Table of Institute and Center Contacts
http://grants1.nih.gov/grants/guide/contacts/parent_K99_R00.html
K22:CareerTransiIonAward
—supportforpostdoctoralfellows
intransi3ontofacultyposi3ons
• forcandidateswithpotenDalfor
producDveindependentresearch
• differencesamongInsDtutes:
mayinvolvetrainingin
intramuralNIHprograms
hbp://grants.nih.gov/grants/new_invesDgators/QsandAs.htm
ApplicaIonforaK99/R00Awardfollowsthesame
processasotherKAwards
• similarapplicaDonpackage:
SF424(R&R)withCareerDevelopmentSupplement
• samedeadlines:Feb12,June12,Oct12
• samegeneralreviewcriteria
BUT,K99/R00applicaIonsmustemphasizetheunique
featuresofthisaward:
•  divisioninto2disDnctbutconnectedphases
•  goalofpreparaDonforindependentresearch
©2015RobertJ.Milner,Ph.D.&JoanM.Lakoski,Ph.D.
ReadtheProgramAnnouncement(PA)
—linktoapplicaIonpackage&download
PA-14-042
(K99/R00)
ApplyforGrantElectronically
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K99/R00awardsarereviewedbythe5criteriaused
forallmentoredKawards
1.  Candidate
TheCandidatemustdemonstratethe
potenIalforindependentresearch
Keyreviewques3ons:
2.  CareerDevelopmentPlan/CareerGoals&
ObjecDves/PlantoProvideMentoring
Whatisthecandidate’spotenDaltobecomeahighly
successfulindependentinvesDgator?
3.  ResearchStrategy
WhatistherecordofresearchproducDvity?
4.  Mentor(s),Consultant(s),Collaborator(s)
Whatisthequalityofthecandidate'spre-and
postdoctoralresearchtrainingexperience?
5.  EnvironmentandInsDtuDonalCommitment
totheCandidate
Thesecriteriaareapplieduniquely
fortheK99/R00award
TheCandidatemustdemonstratethe
potenIalforindependentresearch
Answertheseques3onswith:
Adetailedandcompletebiosketch
Astrongstatementofcommitmenttoacareerin
biomedicalresearch(CandidateBackground)
AdetaileddescripDonofcareergoals&howthese
goalsrelatetopriortraining&experience
(CareerGoals&Objec=ves)
Outstandinglebersofreferencefrom
atleast3well-establishedscienDsts
CareerDevelopmentPlanmustbe
appropriateforthecandidate
Answertheseques3onswith:
Willthecandidatebeabletoachieveanindependent,
tenure-trackposiDonwithintheDmeperiod
requestedfortheK99phase?
CareerDevelopmentPlanmustbe
appropriateforthecandidate
Keyreviewques3ons:
Istheplanappropriateforthecandidate’scurrent
stage&futureresearchcareergoals?
Doestheplanaugmentthecandidate’straining?
IstheplanlikelytocontributesubstanDallytothe
developmentofthecandidateincludinghis/her
successfultransiDontoindependence?
AretheplansforevaluaDngprogressduringtheK99
phaseadequate?
IstheDmelineappropriateforforthetransiDontothe
independentphaseoftheaward?
CareerDevelopmentPlanmustbe
appropriateforthecandidate
Youshouldalso:
AsystemaDcplanthatshowsalogicalprogression
frompriorresearchandtrainingtothetrainingand
researchproposedfortheK99phaseand
subsequentlytotheR00phase.
(CareerGoals&Objec=ves)
JusDfytheneedfortheaward,bothK99&R00phases
andmakeaconvincingcasethattheproposed
supportwillenhanceyourcareer&/orallowthe
pursuitofanovelorpromisingapproachtoa
parDcularresearchproblem.
K99
R00
prior
phase
phase
experience
Atrainingplanthatfitsthepastexperience&future
needsofthecandidate.
(CareerDevelopment&TrainingAc=vi=es)
DescribehowtheplanwillpromoteyourscienDfic
independence,byincludinggrant-wriDng,
communicaDonandlaboratorymanagementskills
andknowledge.
(CareerDevelopment&TrainingAc=vi=es)
©2015RobertJ.Milner,Ph.D.&JoanM.Lakoski,Ph.D.
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IncludeaTimelineforyourCareerGoals&
ObjecIves
Indicatehowthetwo
phasesrelate
ListspecificobjecDvesfor
eachyear
Describeplansfor
subsequentgrant
support
Year1
TheResearchPlanmustbedividedinto
disInctbutconnectedK99andR00phases
Keyreviewques3ons:
K99Phase
IstheproposedK99researchsignificantandsound?
Year2
IstheK99researchappropriatefordeveloping
researchskills&asuccessfulR00researchprogram?
transi=on
Year3
IstheR00phaseresearchscienDficallysoundanda
logicalextensionoftheK99research?
Year4
R00Phase
Year5
TheResearchPlanmustbedividedinto
disInctbutconnectedK99andR00phases
Answertheseques3onswith:
AdescripDonofhowpriorresearch,theK99research,
andtheR00researchintersect:
i.e.,whatyousDllneedtoaccomplishduringtheK99
phaseinordertocompetesuccessfully.
AdetaileddescripDonoftheR00phaseresearch,
includingthenovelty,significance,creaDvity,and
approach.
AdescripDonofhowyourresearchplanrelatesto
yourmentor’sresearchandhowyouwillachieve
researchindependenceyourmentor.
TheMentormusthaveastrongrecordof
researchandmentoring
Answertheseques3onswith:
AmentorthatmeetsthesequalificaDons
(&hasdocumentedthemadequately!)
Ifnot,provideaplantocorrectanydeficiencies:
• co-mentor(s)
• mentoringadvisoryteam
DetailedplansduringtheK99phasefor
• supervisionbythementor(s)
• evaluaDonofprogress&transiDon
(StatementsbyMentor)
©2015RobertJ.Milner,Ph.D.&JoanM.Lakoski,Ph.D.
IstheR00researchsignificant,innovaDve&creaDve?
Doesithavelong-termviability?
IstheR00researchlikelytofosterthecareerofthe
candidateasanindependentinvesDgator?
TheMentormusthaveastrongrecordof
researchandmentoring
Keyreviewques3ons:
Whatisthementor’srecordoftraining?
ArethementorsresearchqualificaDons,stature,and
mentoringrecordappropriate?
Whatisthenature&extentofsupervisionduringthe
K99phase?
IsthereanappropriateplanforevaluaDonof
progress(K99phase)andthetransiDonto
independence?
Areanycollaborators&consultantsqualified?
StatementsbyMentormustalsoexplain
howawardwilldevelopcandidate’scareer
Shouldinclude:
•  plansforcandidate’scareerdevelopment
•  source(s)ofsupportforresearchproject
•  supervision&mentoringofcandidate
•  candidate’steachingload(ifany)
•  planfortransiDonofcandidatetoanindependent
invesDgator
5
Astrongstatementof
Ins3tu3onalCommitmentisessenIal
Keyreviewques3ons:
DoestheinsDtuDonprovideahighquality
environmentforthecandidate’sdevelopment?
AretheresearchfaciliDesandeducaDonal
opportuniDesadequateandappropriateforthe
candidate’sresearchandcareerdevelopmentgoals
duringtheK99phaseoftheaward?
IstheK99sponsoringinsDtuDonstronglycommibed
tofosteringthecandidate’sdevelopmentand
transiDontotheindependent(R00)phase?
Astrongstatementof
Ins3tu3onalCommitmentisessenIal
Answertheseques3onswith:
DescripDonofhowtheinsDtuDonalenvironment&
faciliDesareappropriate&availableforthe
research&careerdevelopmentofthecandidate.
AstronginsDtuDonalstatementofcommitmentto
thecandidateduringtheK99phase&supportfor
transiDontoindependence.
(Thiscommitmentshouldnotbedependenton
receiptoftheaward.)
AstrongstatementofInsItuIonal
CommitmentisessenIal(item9)
• oninsDtuDonalleberhead
• commitmenttocandidate
independentofaward
• agreementtoprovideprotected
Dmeforcandidate’sresearch&
careerdevelopment
• equipment,labspace,office,
faciliDes,resources
LeQerlimitedto1page!
©2015RobertJ.Milner,Ph.D.&JoanM.Lakoski,Ph.D.
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