Overview of Innate Immunity Principles of Immunology 1/19/06

Principles of Immunology
Overview of Innate Immunity
1/19/06
“Education is not preparation for life. Education is
life itself.”
John Dewey
Review(T/F)
 Jenner was the first to introduce
variolation
 Innate immune responses are specific
 T cells are either T-helper or Tcytotoxic cells
 Immunological memory results in an
amanestic response
 All antigens are immunogens
Innate Immunity
 Nonspecific host defenses that exist
prior to exposure to an antigen.
Involves the following components:
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Anatomic
Physiologic
Phagocytic
Inflammatory
Word List
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Antibody
Antigen
Complement
Endocytosis
Humoral
Macrophage
Monocyte
Neutrophil
Barriers to Antigenic Insult
 Anatomic
 Skin
 Mucous membranes
 Physiologic
 Temperature
 pH
 Chemical mediators
Cellular and Inflammatory
Components of Innate Immunity
 Cellular
 Phagocytic cells
 Inflammatory
 Vasodilation
 Capillary permeability
Anatomic Barriers
 Skin
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Epidermis
Dermal layer
Sebaceous glands
Normal flora
Anatomic Barriers
 Mucous membranes
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Physical barrier
Secretions
Cilia
Normal flora
Physiologic Barriers
 Temperature
 Varies by species
 Febrile response
 Endogenous pyrogens
 pH
 Skin
 GI tract
Physiologic Mediators
of Innate Immunity
 Chemical mediators
 Enzymes
 Interferon
 Complement
 Three pathways
 Classical
 MB Lectin
 Alternative
Physiologic Mediators
of Innate Immunity(cont’d)
 Chemical mediators
 Collectins
 Toll-like receptors
 Acute phase proteins
Cellular Component
of Innate Immunity
 Phagocytic cells
 Monocytes
 Neutrophils
 Macrophages
 Non-Phagocytic cells
 Natural killer cells
Inflammatory Response
 Hallmarks of inflammation
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Rubor
Tumor
Calor
Dolor
 Primary cell
 Activated macrophage
Inflammatory Response(cont’d)
 Biological effects
 Vasodilation
 Capillary permeability
 Phagocyte migration
Inflammatory Response(cont’d)
 Chemical mediators of inflammation
 Histamine
 Kinin system
 Fibrin system