DR. DAVID M. WARSHAW (1999)

DR. DAVID M. WARSHAW (1999)
Name:
David M. Warshaw
Address:
Department of Molecular Physiology & Biophysics
University of Vermont College of Medicine
Burlington, Vermont 05405-0068
Telephone:
802-656-4300
Fax:
802-656-0747
E-mail:
[email protected]
Education:
B.S. - 1973 - Electrical Engineering, Rutgers University, New Brunswick, NJ
Ph.D. - 1978 - Physiology and Biophysics, University of Vermont,
Burlington, VT
Postdoctorate - 1978 – Biophysics, Aarhus University, Denmark
- 1978-1983 – UMass Medical School
Professional Experience:
1975 - 1978:
1978 - 1983:
1983 - 1989:
1989 - 1991:
1991-1995:
1995-Present:
Vermont
Graduate Student, Physiology & Biophysics, Univ. of Vermont; Advisor: Dr.
W. Halpern
Postdoctoral Fellow/Instructor, Physiology & Biophysics, UMass Mentor:
Dr. F. Fay
Assistant Professor, Physiology & Biophysics, University of Vermont
Associate Professor, Physiology & Biophysics, University of Vermont
Professor, Molecular Physiology & Biophysics, University of Vermont
Professor and Chairman, Molecular Physiology & Biophysics, University of
Honors:
1988-93:
1989:
Systems"
1999:
1999:
2001:
2001:
American Heart Association Established Investigatorship
Encyclopedia Britannica, author: "Smooth Muscle: Muscles and Muscle
University of Vermont Scholar
Member, Vermont Academy of Science and Engineering
U.S. Rep. for the NHLBI/US- Russia Symposium on Basic Research in CV and
Pulmonary Diseases.
American Heart Association Fellow
Professional Societies
American Heart Association - Basic Science Member
American Physiological Society - Regular Member
Biophysical Society - Senior Member
American Association for the Advancement of Science - Regular Member
Sigma Xi
Publications:
77
Author or co-author of more than 75 peer-reviewed papers in Science, Proceedings of National
Academy of Science USA, Circulation Research, Journal of Cell Biology, Biophysics Journal, and
other journals.
Editorial Work:
Editorial Board (Past & Present): J Vascular Res, Am J Physiol (Cell), J Muscle Res & Cell Motil,
Biophys J
Manuscript Review: Circ Res, PNAS, Nature, J Clin Inv, J Physiol (Lond), Science, J Mol Biol,
JCB, J Cell Sci
Research Interests:
Molecular Motors and Heart Disease: The Warshaw Molecular Motors Group focuses on the
structure and function of myosin, a molecular motor associated with biological movement
ranging from muscle contraction to intracellular vesicular transport. Researchers still do not
understand how myosin converts the energy from ATP hydrolysis into mechanical work as the
molecular motor moves along its actin track. Our approach is a comparative one by studying
myosin from various tissue sources that differ substantially in both their structure and
functional capacities. Additional insight can be obtained from genetically mutated myosin and
actin, which lead to inherited forms of human heart failure. We use the power of molecular
biophysics and single molecule techniques to characterize the molecular performance of the
actomyosin motor.
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