Alberto Martini Brief curriculum vitae 1972:M.D. University of Pavia

Alberto Martini
Brief curriculum vitae
1972:M.D. University of Pavia, Italy
1975: Specialty in Hematology, University of Pavia, Italy
1978: Specialty in Pediatrics, University of Pavia, Italy
1981: Specialty in Nephrology, University of Parma, Italy
1979 -1983: Assistant Professor of Pediatrics, University of Pavia, Italy
1983 -1995: Associate Professor of Pediatrics, University of Pavia, Italy
1995 - 2001: Professor of Pediatrics Dept of Pediatrics, University of Pavia , Italy
2001 – date: Professor of Pediatrics, Dept of Pediatrics, University of Genoa, Director Pediatria II
Reumatologia (EULAR Centre of Excellence in Rheumatology 2008-13), IRCCS G Gaslini,
Genoa, Italy
President of the Pediatric Rheumatology European Society (PRES),
Chairman of the Pediatric Rheumatology International Trial Organization (PRINTO).
Past Chairman of the Council of the Italian Full Professors of Paediatrics (2008-2012)
Co-Editor of “Clinical and Experimental Rheumatology” and “Pediatric Rheumatology”, Member
of the Editorial Board of “Annals of Rheumatic Diseases” and of “Current Reumatology Reviews”,
Associated Editor of “Frontiers in Pediatric Clinical Pharmacology”, Member of the International
Advisory Board of “Paediatrics and Child Health”
Selected English bibliography (2005-2012)
Moretti C, Viola S, Pistorio A, Magni-Manzoni S, Ruperto N, Martini A, Ravelli A. Relative
responsiveness of condition-specific and generic health status measures in juvenile idiopathic
arthritis.
Ann Rheum Dis. 64;257-61:2005
Perfumo F, Martini A. Lupus nephritis in children.
Lupus 14;83-88:2005
Ruperto N, Nikishina I,. Pachanov ED, Shachbazian Y, Prieur AM, Mouy R, Joos R, Zulian F,
Schwarz R, Artamonova V, Emminger W, Bandeira M, Buoncompagni A, Foeldvari I, Falcini F,
Baildam E, Kone-Paut I, Alessio M, Gerloni V, Lenhardt A, Martini A, for the Paediatric
Rheumatology International Trials Organisation (PRINTO), Hanft G, Sigmund R, Simianer S. A
randomized trial of 2 doses of meloxicam compared to naproxen in juvenile idiopathic arthritis:
short and long term efficacy and safety results.
Arthritis Rheum 52;563-72:2005
D’Osualdo A, Picco P, Caroli F, Gattorno M, Giacchino R, Fortini P, Corona F, Tommasini A,
Salvi G, Specchia F, Obici L, Meini A, Ricci A, Ravazzolo R, Martini A, Ceccherini I. MVK
mutations and associated clinical features in Italian patients affected with autoinflammatory
disorders and recurrent fever
Eur J Hum Genet 13;314-20: 2005
De Benedetti F, Martini A. Targeting the interleukin-6 receptor: a new treatment for systemic
juvenile idiopathic arthritis?
Arthritis Rheum 52; 687-93: 2005
Ravelli A, Felici E, Magni-Manzoni S, Pistorio A, Novarini C, Bozzola E, Viola S, Martini A:
Patients with antinuclear antibody-positive juvenile idiopathic arthritis constitute a homogeneous
subgroup irrespective of the course of joint disease
Arthritis Rheum 52; 826-32: 2005
Falcone A, Cassone R, Rossi F, Pistorio A, Martini A, Ravelli A. Interobserver agreement of the
physician’s global assessment of disease activity in children with juvenile idiopathic arthritis. Clin
Exp Rheumatol 23;113-16, 2005
Gattorno M, Prigione I, Moranti F, Gregorio A, Chiesa S, Ferito F, Favre A, Uccelli A, Gambini C,
Martini A, Pistoia V: Phenotypic and functional characterization of CCR7+ and CCR7- CD4+
memory T cells homing to the joints in juvenile idiopathic arthritis.
Arthritis Res Ther 7(2):R256-67; 2005
Ravelli A, Martini A: Antiphospholipid syndrome
Pediatr Clin North Am 52; 469-91:2005
A.Ravelli, S.Magni-Manzoni, A.Pistorio, C.Besana, T.Foti, N.Ruperto, S.Viola, A.Martini.
Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic
juvenile idiopathic arthritis.
J Pediatr. 146,598-604, 2005
Ruprecht CR, Gattorno M, Ferlito F, Gregorio A, Martini A, Lanzavecchia A, Sallusto F:
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory cells in inflamed joints.
J Exp Med 201, 1793-1803, 2005
Viola S, Felici E, Magni-Manzoni S, Pistorio A, Buoncompagni A, Ruperto N, Rossi F, Bartoli M,
Martini A, Ravelli A. Development and validation of a clinical index for assessment of long-term
damage in juvenile idiopathic arthritis.
Arthritis Rheum. 52,2092-2102 2005
Ruperto N, Garcia-Munitis P, Luca Villa L, Pesce M, Aggarwal A, Fasth A, Avcin T, Bae S-C,
Balogh Z, Caifeng L, De Inocencio J, Dibra M, Dolezalova P, El Miedany Y, Flato B, Harjacek M,
Huppertz H-I, Kanakoudi Tsakalidou F, Wulffraat N, Lahdenne P, Melo-Gomes JA, Mihaylova D,
Nielsen S, Nikishina I, Ozdogan MD H, Pagava K, Panaviene V, Prieur A-M, Romicka MD A-M,
Rumba I, Shafaie N, Susic G, Takei S, Uziel Y, Vesely V, Woo P, Martini A. THE PRINTO/PRES
international web-site for families of children with rheumatic diseases: www.pediatricrheumatology.printo.it
Ann Rheum Dis 64;1101-1106: 2005
Magni-Manzoni S, Cugno C, Pistorio A, Garay S, Tsitsami E, Gasparini C, Viola S, Ruperto N,
Martini A, Ravelli A: Responsiveness of clinical measures to flare of disease activity in juvenile
idiopathic
arthritis.
Clin Exp Rheumatol 23, 421-5, 2005
Minetti C, Gattorno M, Repetto S, Gregorio A, Pedemonte M, Zara F, Bruno C, Martini A:
Chemokine receptor CCR7 is expressed in muscle fibers in juvenile dermatomyositis.
Biochem Bioph Res Co 540-3, 333, 2005
Ravelli A, Ruperto N, Martini A: Outcome in juvenile onset systemic lupus erythematosus
Curr Opin Rheumatol 17,568-73, 2005
Gattorno M, Martini A: Inherited autoinflammatory syndromes: an expanding new group of
chronic inflammatory diseases.
Clin Exp Rheumatol 23,133-6,2005
Ruperto N, Ravelli A, Cuttica R, Espada G, Ozen S, Porras O, Sztajnbok F, Falcini F, Kasapcopur
O, Venning H, Bica B, Merino R, Coto C, Ros J, Susic G, Gamir ML, Minden K, See Y, Uziel Y,
Mukamel M, Riley P, Zulian F, Olivieri AN, Cimaz R, Girschick H, Rumba I, Cavuto S, Pistorio
A, Lovell DJ, Martini A: The Pediatric Rheumatology International Trials Organization criteria
for the evaluation of response to therapy in juvenile systemic lupus erythematosus: Prospective
validation of the disease activity core set.
Arthritis Rheum 52, 2854-64, 2005.
Felici E, Novarini C, Magni-Manzoni S, Magnani A, Bozzola E, Buoncompagni A, Martini A,
Ravelli A: Courses of joint disease in patients with antinuclear antibody-positive juvenile idiopathic
arthritis
J Rheumatol 32,1805-10,2005.
Gattorno M, Martini A: The immune system and the inflammatory response. In Textbook of
Pediatric Rheumatology, Cassidy JT, Petty RE, Laxer RM, Lindsley CB Eds, Elsevier Saunders,
Philadelphia, 2005 pp19-63
Bandeira M, Falcone A, Pistorio A, Ruperto N, Magni-Manzoni S, Buoncompagni A, Sala E, Loy
A, Martini A, MD, Ravelli A: Weighting improves the information provided by joint counts on the
severity of arthritis and its impact on patients’ well-being in juvenile idiopathic arthritis
Rheumatology 2006; 45:343-347
D’Osualdo A, Ferito F, Prigione I, Obici L, Meini A, Zulian F, Postillo A, Corona F, Barcellona R,
Traverso F, Di Duca M, Santamaria G, Picco P, Baldi M, Plebani A, Ravazzolo R, Ceccherini I,
Martini A, Gattorno M. Neutrophils from patients with tnfrsf1a mutations display resistance to
tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications
Arthritis Rheum 2006;54:998-1008
Martini A: Rheumatoid factor negative polyarthritis.
In: The Textbook of Arthritis in Children and Adolescents. Szer I, Kimura Y Malleson PN,
Southwood TR, (eds) Oxford University Press, Oxford, 2006 pp 244-51
Garcia-Munitis P, Bandeira M, Pistorio A, Magni-Manzoni S, Ruperto N, Schivo A, Martini A,
Ravelli A: Level of agreement between children, parents and physicians in rating pain intensity in
juvenile idiopathic arthritis.
Arthritis Rheum 2006; 55;177-183
Marciano R, Giacopelli F, Divizia MT, Gattorno M, Felici E, Pistorio A, Martini A, Ravazzolo R,
Picco P: A polymorphic variant inside the osteopontin gene shows association with disease course
in oligoarticular idiopathic juvenile arthritis
Ann Rheum Dis 2006; 65: 662-5
Ruperto N, Ravelli A, Oliveira S, Alessio M, Mihaylova D, Pasic S, Cortis E, Apaz M, BurgosVargas R, Kanakoudi-Tsakalidou F, Norambuena X, Corona F, Gerloni V, Hagelberg S, Aggarwal
A, Dolezalova P, Saad CM, Bae SC, Vesely R, Avcin T, Foster H, Duarte C, Herlin T, Horneff G,
Lepore L, Rossum MV, Trail L, Pistorio A, Andersson-Gare B, Giannini EH, Martini A: The
Pediatric Rheumatology International Trials Organization/American College of Rheumatology
provisional criteria for the evaluation of response to therapy in juvenile systemic lupus
erythematosus:
Prospective
validation
of
the
definition
of
improvement.
Arthritis Rheum. 2006;55:355-363
Ravelli A, Ruperto R, Trail L, Felici E, Sala E, Martini A: Clinical assessment in juvenile
dermatomyositis
Autoimmunity 2006;39:197-203
Sironi M, Martinez FO, D'Ambrosio D, Gattorno M, Polentarutti N, Locati M, Gregorio A, Iellem
A, Cassatella MA, Van Damme J, Sozzani S, Martini A, Sinigaglia F, Vecchi A, Mantovani
A.Differential regulation of chemokine production by Fc{gamma} receptor engagement in human
monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2).
J Leukoc Biol. 2006;80:342-9.
Gutiérrez-Suarez R, Ruperto N, Gastaldi R, Pistorio A, Felici E, Burgos-Vargas R, Martini A,
Ravelli A: A proposal for a pediatric version of the Systemic Lupus International Collaborating
Clinics/American College of Rheumatology damage index based on the analysis of 1015 patients
with juvenile-onset systemic lupus erythematosus
Arthritis Rheum 2006;54:2989-2996
M.Bandeira, S.Buratti, M.Bartoli, C.Gasparini, L.Breda, A.Pistorio, S.Grassi, M.G.Alpigiani,
G.Barbano, L.L.Janz-Junior, A.Martini, A.Ravelli. Relationship between damage accrual, disease
flares and cumulative drug therapies in juvenile-onset systemic lupus erythematosus.
Lupus 2006;15:515-20.
Rossi F, Di Dia F, Galipò O, Pistorio A, Valle M, Magni-Manzoni S, Ruperto N, Tomà P,
Martini A, Ravelli A: Use of the sharp and larsen scoring methods in the assessment of
radiographic progression in juvenile idiopathic arthritis
Arthritis Rheum 2006;55:717-723
Ravelli A, Martini A: Remission in juvenile idiopathic arthritis
Clin Exp Rheumatol 2006;24:S105-10
E. Palmisani, N.Solari, S.Magni-Manzoni, A.Pistorio, E.Labò, S.Panigada, A.Martini, A.Ravelli.
Correlation between juvenile idiopathic arthritis activity and damage measures in early, advanced
and long-standing disease.
Arthritis Rheum. 2006;55:843-849
Ruperto R, Ravelli A, Castell E, Gerloni V, Haefner R, Malattia M, Kanakoudi-Tsakalidou JF,
Nielsen S, Bohnsack J, Gibbas D, Rennebohm R, Voygioyka O, Balogh Z, Lepore L, Macejkova
E, Wulffraat N, Oliveira S, Russo R, Buoncompagni A, Odete Hilario MO, Kimura Y, Murray K,
Szer I, Alpigiani MG, Passo, M, Lovell DJ, Merino R, Prieur AM, Madson K, Martini A, Giannini
EH: Cyclosporine a in juvenile idiopathic arthritis. results of the PRCSG/PRINTO phase IV post
marketing surveillance study
Clin Exp Rheumatol 2006;24:599-605
Sztajnbok F, Coronel-Martinez DL, Diaz-Maldonado A, Novarini C, Pistorio A, Viola S, Ruperto
R, Buoncompagni A, Martini A, Ravelli A. Discordance between physician’s and parent’s global
assessments in juvenile idiopathic arthritis
Rheumatology 2007; 46:141-45
Gutiérrez-Suárez R, Pistorio A, Cespedes Cruz A, Norambuena X, Flato B, Rumba I, Harjacek M,
Nielsen S, Susic G, Mihaylova D, Huemer C, Melo GomesJ, Andersson-Gare B, Balogh Z, De
Cuntoc, Vesely R, Pagava K, Romicka A, Burgos–Vargas R, Martini A, Ruperto N: Health
related quality of life of patients with juvenile idiopathic arthritis coming from 3 different
geographic areas.The PRINTO multinational quality of life cohort study.
Rheumatology 2007;46:314-20
Oliveira S, Ravelli A, Pistorio A, Castell E, Malattia C, Prieur AM, Saad-Magalhães C, Murray KJ,
Bae SC, Joos R, Foeldvari I, Duarte-Salazar C, Wulffraat N, Lahdenne P, Dolezalova P, de
Inocencio J, Kanakoudi-Tsakalidou F, Hofer M, Nikishina I, Ozdogan H, Hashkes PJ, Landgraf JM,
Martini A, Ruperto N. Proxy-reported health related quality of life of patients with juvenile
idiopathic arthritis.
Arthritis Rheum 2007;57:35-43.
Ravelli A, Martini A. Juvenile idiopathic arthritis.
Lancet, 2007;369:767-778
Martini A. What is juvenile psoriatic arthritis?
Arthritis Rheum (letter) 2007;56:1368
Gregorio A, Gambini C, Gerloni V, Parafioriti A, Soriani MP, Gregorio S, De Marco G, Rossi F.,
Martini A, Gattorno M: Lymphoid neogenesis in juvenile idiopathic arthritis.
Rheumatology 2007;46:308-13
Caroli F, Pontillo A, D'Osualdo A, Travan L, Ceccherini I, Crovella S, Alessio M, Stabile A,
Gattorno M, Tommasini A, Martini A, Lepore L: Clinical and genetic characterization of Italian
patients affected by CINCA syndrome.
Rheumatology 2007;46:473-78
Gattorno M, Chicha L, Gregorio A, Ferlito F, Rossi F, Jarrossay D, Lanzavecchia A, Martini A,
Manz MG: Distinct expression pattern of IFN-{alpha} and TNF-{alpha} in juvenile idiopathic
arthritis synovial tissue.
Rheumatology 2007;46:657-665
Massa M, Passalia M, Magni Manzoni S, Campanelli R, Ciardelli L, Puga Yung G, Kamphuis S,
Pistorio A, Meli Tech V, Sette A, Prakken B, Martini A, Albani S. Differential recognition of heat
shock protein dnaj-derived epitopes by effector and regulatory T cells leads to modulation of
inflammation in juvenile idiopathic arthritis.
Arthritis Rheum 2007;56:1648-57
Martini A, Spencer CH. Pediatric Rheumatology - a continuation of Pediatric Rheumatology
Online Journal.
Pediatr Rheumatol 2007;5:1
Filocamo G, Sztajnbok F, Cespedes-Cruz A, Magni-Manzoni S, Pistorio A, Viola S, Ruperto N,
Buoncompagni A, Loy A, Martini A, Ravelli A. Development and validation of a new short and
simple measure of physical function for juvenile idiopathic arthritis
Arthritis Rheum 2007;57:913-920
Consolaro A, Vitale R, Pistorio A, Lattanzi B, Ruperto N, Malattia C, Filocamo G, Viola S,
Martini A, Ravelli A: Physician’s and parent’s ratings of inactive disease are frequently discordant
in juvenile idiopathic arthritis
J Rheumatol 2007;34:1773-6
Ruperto N, Bazso A, Ravelli A, Malattia C, Filocamo G, Pistorio A, Rodriguez Lozano AL, Viola
S, Martini A: The Paediatric Rheumatology International Trials Organization
(PRINTO) criteria to define response to therapy in juvenile systemic lupus erythematosus
Lupus. 2007;16:670-6.
A.Pringe, L.Trail, N.Ruperto, A.Buoncompagni, A.Loy, L.Breda, A.Martini, A.Ravelli.
Macrophage activation syndrome in juvenile systemic lupus erythematosus: an underrecognized
complication?
Lupus 2007;16:587-92.
RupertoN, Lovell DJ, Cuttica R, Wilkinson N, Woo P, Espada G, Wouters C, Silverman ED,
Balogh Z, Henrickson M, Apaz M, Baildam E, Fasth A, Gerloni V, Lahdenne P, Prieur AM,
Ravelli A, Saurenmann RK, Gamir ML, Wulffraat N, Marodi L, Petty RE, Joos R, Zulian F,
McCurdy D, Myones BL, Nagy K, Reuman P, Szer I, Travers S, Beutler A, Keenan G, Clark J,
Visvanathan S, Fasanmade A, Raychaudhuri A, Mendelsohn A, Martini A, Giannini EH:
A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of
polyarticular course juvenile rheumatoid arthritis
Arthritis Rheum 2007;56:3096-3106
Ravelli A, Ioseliani M, Norambuena X, Sato S, Pistorio A, Rossi F, Ruperto N, Magni-Manzoni S,
Ullmann N, Martini A. Adapted versions of the Sharp-van Der Heijde score are reliable and valid
for assessment of radiographic progression in juvenile idiopathic arthritis
Arthritis Rheum 2007;56:3087-3095
Gattorno M, Tassi S, Carta S, Delfino L, Ferlito F, Pelagatti MA, D’Osualdo A, Buoncompagni A,
Alpigiani MG, Alessio M, Martini A, Rubartelli A. Pattern of interleukin-1 secretion in response
to LPS and ATP in patients with CIAS1 mutations before and after interleukin-1 blockade.
Arthritis Rheum 2007;56:3138-3148
Ravelli A, Martini A. Antiphospholipid syndrome in pediatrics
Rheum Dis Clin North Am. 2007;33:499-523
Ravelli A, Pringe A, Malattia C, Sala I, Martini A. Macrophage activation syndrome in childhood
rheumatic diseases. Curr Rheumatol Rev. 2007;16:587-92
Di Rocco M, Fantasia AR, Taro M, Loy A, Forlino A, Martini A. Systemic lupus erythematosuslike disease in a 6-year-old boy with prolidase deficiency.
J Inherit Metab Dis 2007;30:814
Vivarelli MS, D’Urbano LE, Insalaco A, Lunt M, Jury F, Tozzi AE, Ravelli A, Martini A, Donn
R, De Benedetti F : Macrophage migration inhibitory factor (MIF) and oligoarticular juvenile
idiopathic arthritis (o-JIA): association of MIF promoter polymorphisms with response to intraarticular glucocorticoids.
Clin Exp Rheumatol 2007;25:775-781
Ruperto R, Ravelli A, Pistorio A, Ferriani V, Calvo I, Ganser G, Brunner J, Dannecker G, Silva
CA, Stanevicha V, Ten Cate R, Van Suijlekom-Smit LWA, Voygioyka O, Fischbach M, Foeldvari
I, Hilario O, Modesto C, Saurenmann RK, Sauvain M-J, Scheibel I, Sommelet D, Tambic-Bukovac
L, Barcellona R, Brik R, Ehl S, Jovanovic M, Rovensky J, Bagnasco F, Lovell DJ, Martini A: The
provisional pediatric rheumatology international trial organization/american college of
rheumatology/european league againts rheumatism disease activity core set for the evaluation of
response to therapy in juvenile dermatomyositis: a prospective validation study
Arthritis Rheum 2008;59:4-13
Céspedes-Cruz A, Gutiérrez-Suárez R, Pistorio A, Ravelli A, Loy A, Murray KJ, Gerloni V,
Wulffraat N, Oliveira S, Walsh J, Calvo Penades I, Alpigiani MG, Lahdenne P, Saad-Magalhães C,
Cortis E, Lepore L, Kimura Y, Wouters, Martini A, Ruperto N. Methotrexate improves the healthrelated quality of life of children with juvenile idiopathic arthritis
Ann Rheum Dis 2008;67:309-314
Traggiai E, Volpi S, Schena F, Gattorno M, Ferlito F, Moretta L, Martini A. Bone Marrow-derived
Mesenchymal Stem Cells Induce Both Polyclonal Expansion and Differentiation of B Cells Isolated
Form Healthy Donors and Systemic Lupus Erythematosus Patients.
Stem Cells 2008;26:562-9
A Ravelli, A Martini. Juvenile idiopathic arthritis.
In Clinical Immunology, Rich RR, Shearer WT, Fleischer, Schroeder HW Jr, Weyand CM, Frew AJ
(Eds), Elsevier, London, 2008 pp 789-801
Ruperto N, Martini A, Lovell DJ, Giannini EH: Performing trials in children with rheumatic
diseases: Comment on the editorial by Lehman
Arthritis Rheum 2008;58:1201-1202 (letter)
Bartoli M, Tarò M, Magni-Manzoni S, Pistorio A, Traverso M, Viola S, Magnani A, Gasparini C,
Martini A, Ravelli A. The magnitude of early response to methotrexate therapy predicts long-term
outcome of patients with juvenile idiopathic arthritis
Ann Rheum Dis 2008;67):370-4.
Gattorno M, Piccini A, Lasigliè D, Tassi S, Brisca G, Carta S, Delfino L, Ferito F, Pelagatti MA,
Caroli F, Buoncompagni A, Viola S, Loy A, Sironi M, Vecchi A, Ravelli A, Martini A, Rubartelli
A. The pattern of response to anti IL-1 treatment distinguishes two subset of patients with systemic
onset juvenile idiopathic arthritis.
Arthritis Rheum 2008; 58:1505-1515
Gattorno M, Pelagatti MA, Meini A, Obici L, Barcellona R, Federici S, Buoncompagni A, Plebani A,
Merlini G, Martini A. Persistent efficacy of Anakinra in TRAPS patients
Arthritis Rheum 2008; 58:1516-1520
Ruperto N, Meiorin S, Iusan SM, Ravelli A, Pistorio A, Martini A. Consensus procedures and their
role in pediatric rheumatology.
Curr Rheumatol Rep. 2008 ;10:142-6
Gattorno M, Sormani MP, A. D’Osualdo A, Pelagatti MA, Caroli F, Federici S, Lecconi M, Solari
N, A. Meini A, Zulian F, Obici L, Breda L, Martino S, Tommasini A, Bossi G, Govers A,
Touitoun I, Woo P, J. Frenkel J, Kone-Paut I, Baldi M, Ceccherini I, Martini A. A diagnostic score
for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children.
Arthritis Rheum. 2008;58:1833-1838
Bosco MC, Delfino S, Ferito F, Puppo M, Gregorio A, Gambini C, Gattorno M, Martini A,
Varesio L: The hypoxic environment regulates production of vascular endothelial growth factor and
osteopontin by synovial monocytes in juvenile idiopathic arthritis
Arthritis Rheum 2008;58(:1823-1832
Magni-Manzoni S, Pistorio A, Labò E, Viola S, Garcia-Munitis P, Panigada S, Visconti C,
Buoncompagni A, Martini A, Ravelli A. A longitudinal analysis of physical functional disability
over the course of juvenile idiopathic arthritis.
Ann Rheum Dis 2008;67:1159-64
Gattorno M, Federici S, Pelagatti MA, Corsi R, Brisca G, Malattia C, Martini A. Diagnosis and
management of Autoinflammatory syndromes in childhood.
J Clin Immunol 2008;28 Suppl 1:S73-83.
Magni-Manzoni S, Ruperto N, Pistorio A, Sala A, Solari N, Palmisani E, Cugno C, Bozzola E,
Martini A, Ravelli A. Development and validation of a preliminary definition of low (or minimal)
disease activity in juvenile idiopathic arthritis
Arthritis Rheum 2008;59:1120-1127.
Meiorin S, Pistorio A, Ravelli A,. Iusan SM, Filocamo G, Trail L, Oliveira S, Cuttica R, Espada G,
Alessio M, Mihaylova D, Cortis E, Martini A, Ruperto N: Validation of the Childhood Health
Assessment Questionnaire in active juvenile systemic lupus erythematosus.
Arthritis Rheum 2008;59:1112-111
Ruperto N, Lovell DJ, Quartier P, Paz E, Rubio-Pérez N, Silva CA, Abud-Mendoza C, BurgosVargas R, Gerloni V,. Melo-Gomes JA, Saad-Magalhães C, Sztajnbok F, Goldenstein-Schainberg
C, Scheinberg M, Calvo Penades I, Fischbach M, Orozco J, Hashkes PJ, Hom C, Jung L, Lepore L,
Oliveira S, Wallace C, Sigal LH, Block AJ, Covucci A, Martini A, Giannini EH: Efficacy and
safety of abatacept in children with juvenile idiopathic arthritis: a randomized, double-blind,
placebo-controlled withdrawal trial.
Lancet 2008; 372: 383–91
Lovell DJ, Ruperto N, Goodman S, Reiff A, Jung L, Jarosova K, Nemcova D, Mouy R, Sandborg
C, Bohnsack J, Elewaut D, Foeldvari I, Gerloni V, Rovensky J, Minden K, Vehe RK, Weiner LW,
Horneff G, Huppertz H-I, Olson NY, Medich JR, Carcereri-De-Prati R, McIlraith MJ,. Giannini
EH, Martini A. A Randomized, Placebo-Controlled Trial of Adalimumab with and without
Methotrexate in Children with Polyarticular Juvenile Rheumatoid Arthritis.
N Engl J Med 2008;339:810-820
Filocamo G, Buoncompagni A, Viola S, Loy A, Malattia M, Ravelli A, Martini A: Treatment of
Takayasu arteritis with tumor necrosis factor antagonists.
J Pediatr 2008;153:432-4.
Nielsen S, Ruperto N, Gerloni V, Simonini G, Cortis E, Lepore L, Alpigiani MG, Zulian F, Corona
F, Alessio M, Barcellona R, Gallizzi R, Rossi F, Magni-Manzoni S, Lombardini G, Filocamo G,
Raschetti R, Martini A, Ravelli A. Preliminary evidence that etanercept may reduce radiographic
progression in juvenile idiopathic arthritis.
Clin Exp Rheumatol 2008;26:688-92
Ruperto N, Martini A. Network in pediatric rheumatology: the example of the Pediatric
Rheumatology International Trials Organization.
World J Pediatr 2008; 4:186-91.
Solari N, Viola S, Pistorio A, Magni-Manzoni S, Vitale R, Ruperto N,Ullmann N, Filocamo G,
Martini A, Ravelli A: Assessing current outcomes of juvenile idiopathic arthritis: a cross-sectional
study in a tertiary-center sample.
Arthritis Rheum 2008;59:1571-1579
Avcin T, Cimaz R, Silverman ED, Cervera R, Gattorno M, Garay S, Berkun Y, Sztajnbok FR, Silva
CA, Campos LM, Saad-Magalhaes C, Rigante D, Ravelli A, Martini A, Rozman B, Meroni PL.
Pediatric Antiphospholipid Syndrome: Clinical and Immunologic Features
of 121 Patients in an International Registry.
Pediatrics 2008;122:1100-7
Malattia C, Damasio MB, Magnaguagno F, Pistorio A, Valle M, Martinoli C, Viola S,
Buoncompagni A, Loy A, Ravelli A, Tomà P, Martini A: Magnetic resonance imaging,
ultrasonography and conventional radiography in the assessment of bone erosions in juvenile
idiopathic arthritis.
Arthritis Rheum 2008;59:1764-1772
Ravelli A, MartiniA.: Macrophage activation syndrome
In Pediatrics in Systemic Autoimmune Diseases, R Cimaz and T Lehman EdsElsevier, Amsterdam
2008 p 55-63
Picco P, Brisca G, Traverso F, Loy A, Gattorno M, Martini A: Successful treatment of idiopathic
recurrent pericarditis with the IL-1 beta receptor antagonist (Anakinra); a new autoinflammatory
disease?
Arthritis Rheum 2009; 60: 264-68
Bazso A, Consolaro A, Ruperto N, Pistorio A, Viola S, Magni-Manzoni S, Malattia C,
Buoncompagni A, Loy A, Martini A, Ravelli A. Development and testing of reduced joint counts
in juvenile idiopathic arthritis
J Rheumatol 2009;36:183-90
Magnani A, Pistorio A, Magni-Manzoni S, Falcone A, Lombardini G, Bandeira M, Rossi F, Sala I,
Martini A, Ravelli A. Achievement of a state of inactive disease at least once in the first 5 years
predicts better outcome of patients with polyarticular juvenile idiopathic arthritis.
J Rheumatol 2009;36:628-34
Apaz M, Saad-Magalhaes C, Pistorio A, Ravelli A, De Oliveira Sato J, Marcantoni MB, Meiorin S,
Filocamo G, Pilkington C, Maillard S, Al-Mayouf S, Prahalad S, Fasth A, Joos R, Schikler KN,
Mozolova D, Landgraf JM, Martini A, Ruperto N. "Health related quality of life of patients with
juvenile dermatomyositis. results from the PRINTO multinational quality of life cohort study",
Arthritis Rheum 2009;61:509-517.
Consolaro A, Ruperto N, Bazso A, Pistorio A, Magni-Manzoni S, Filocamo G, Malattia C, Viola S,
Martini A, Ravelli A. Development and validation of a composite disease activity score for
juvenile idiopathic arthritis.
Arthritis Rheum 2009;61:658-666
Gattorno M, La Regina M, Martini A, Manna R. An update on autoinflammatory diseases. new
concepts for new and old diseases.
Clin Exp Rheumatol 2009;27:354-65.
Bosco MC, DelfinoS, Ferlito F, Puppo M, Gregorio A, Gambini C , Gattorno M, Martini A,
Varesio L. The hypoxic environment regulates production of vascular endothelial growth factor and
osteopontin by synovial monocytes in juvenile idiopathic arthritis.
J Rheumatol 2009;36:1318-29.
Meiorin S, FilocamoG, Pistorio A, Magni-Manzoni S, Sztajnbok F, Cespedes-Cruz A, Magnani
A, Ruperto N, Martini A, Ravelli A. Impact of involvement of individual joint groups
on subdimensions of functional ability scales in juvenile idiopathic arthritis.
Clin Exp Rheumatol 2009; 27: 527-33
Gattorno M,. Caorsi R, Meini A, Cattalini M, Federici S, Zulian F, Cortis E, Calcagno G,
Tommasini A, Consolini R, Simonini G, Pelagatti MA, Baldi M, Ceccherini I, Plebani A, Frenkel
J, Soriani MP, Martini A. Differentiating PFAPA syndrome from monogenic periodic fevers.
Pediatrics 2009;124:721-28
Parodi A, Davì S, Pringe AB, Pistorio A, Ruperto N, Magni-Manzoni S, Miettunen P, BaderMeunier B, Espada G, Sterba G, Ozen S, Wright D, Saad Magalhães C, Khubchandani R, Michels
H, Woo P, Iglesias A, Guseinova D, Bracaglia C, Hayward K, Wouters C, Grom A, Vivarelli M,
Fischer A, Breda L, Martini A, Ravelli A. Macrophage activation syndrome in juvenile systemic
lupus erythematosus. A multinational multicenter study of 38 patients.
Arthritis Rheum 2009;60:3388-99
Ferretti M, Gattorno M, Chiocchetti A, Mesturini R, Orilieri E, Bensi T, Sormani MP, Cappellano
G, Cerutti E, Nicola S, Biava A, Bardelli C, Federici S, Ceccherini I, Baldi M, Santoro C, Dianzani
I, Martini A, Dianzani U. The 423Q polymorphism of the X-linked inhibitor of apoptosis gene
influences monocyte function and is associated with periodic fever.
Arthritis Rheum 2009;60:3476-84
Panigada S, Ravelli A, Silvestri M, Granata C, Magni-Manzoni S, Cerveri I, Dore R, Tomà P,
Martini A, Rossi GA, Sacco O. HRCT and pulmonary function tests in monitoring of lung
involvement in juvenile systemic sclerosis.
Pediatr Pulmonol. 2009;44:1226-1234
Gattorno M, Martini A, Goldbach-Mansky R, Aubert P, Ferguson PJ. Monogenic
autoinflammatory syndromes
In “A Clinician’s Pearles and Myths in Rheumatology” JH Stone Ed, Springer 2009 p33-49
Corcione A, Ferlito F, Gattorno M, Gregorio A, Pistorio A, Gastaldi R, Gambini C, Martini A,
Traggiai E, Pistoia V. Phenotypic and functional characterization of switch memory B cells from
patients with oligoarticular juvenile idiopathic arthritis.
Arthritis Res Ther 2009, 11:R150: 1-12
Saad-Magalhães C, Pistorio A, Ravelli A, Filocamo G, Viola S, Brik R, Mihaylova D, ten Cate R,
Andersson-Gare B, Ferrian V, Minden K, Hashkes P, Rygg M, Sauvain M-J, Venning H, Martini
A, Ruperto N. Does removal of aids/devices and help make a difference in the childhood health
assessment questionnaire disability index?
Ann Rheum Dis 2010;69:82-87
Malattia C, Damasio MB, Basso C, Verri A, Magnaguagno F, Viola S, Gattorno M, Ravelli A,
Tomà P, Martini A. Dynamic Contrast-Enhanced Magnetic Resonance Imaging in the assessment
of disease activity in patients with Juvenile Idiopathic Arthritis.
Rheumatology 2010;49:178-85.
Bertamino M, Rossi F, Pistorio A, Lucigrai G, Valle M, Viola S, Magni-Manzoni S, Malattia C,
Martini A, Ravelli A. Development and initial validation of a radiographic scoring system for the
hip in juvenile idiopathic arthritis.
J Rheumatol. 2010;37:432-9
Ravelli A, Trail L; Ferrari C, Ruperto N, Pistorio A, Pilkington C, Maillard S, Oliveira S,
Sztainbock F, Cuttica R, Beltramelli M, Corona F, Katsicas M, Russo R, Ferriani V, Burgos-Vargas
R, Magni-Manzoni S, Solís-Vallejo E, Bandeira M, Zulian F, Baca V, Cortis E, Falcini F, Alessio
M, Alpigiani MG, Gerloni V, Saad-Magalhaes C, Podda R, Silva C, Lepore L, Felici E; Rossi F,
Sala E, Martini A. Long-term outcome and prognostic factors of juvenile dermatomyositis: a
multinational, multicenter study of 490 patients.
Arthritis Care Res. 2010;62:63-72.
Ruperto N, Lovell DJ, Cuttica R, Woo P, Meiorin S, Wouters C, Silverman ED, Balogh Z,
Henrickson M, Davidson J, Foeldvari I, Imundo L, Simonini G, Oppermann J, Xu S, Shen YK,
Visvanathan S, Fasanmade A, Mendelsohn A, Martini A, Giannini EH. Long-term efficacy and
safety of infliximab plus methotrexate for the treatment of polyarticular course juvenile rheumatoid
arthritis: findings from an open-label treatment extension.
Ann Rheum Dis. 2010;69:718-722.
Foell D, Wulffraat N, Wedderburn LR, Wittkowski H, Frosch M, Gerß J, Stanevicha V, Mihaylova
D, Ferriani V, Kanakoudi Tsakalidou F, Foeldvari I, Cuttica R, Gonzalez B, Ravelli A,
Khubchandani R, Oliveira S, Armbrust W, Garay S, Vojinovic J, Norambuena X, Gamir ML,
García-Consuegra J, Lepore L, Susic G, Corona F, Dolezalova P, Pistorio A, Martini A, Ruperto
N, Roth R. Methotrexate withdrawal at 6 vs 12 months in Juvenile Idiopathic Arthritis in remission.
A randomized clinical trial
JAMA 2010;303:1266-73.
Ruperto N, Ozen S, Pistorio A, Dolezalova P, Brogan P, Cabral DA,Cuttica R, Khubchandani R,
Lovell DJ, O'Neil KM, Quartier P, Ravelli A, Iusan SM, Filocamo GF, Saad Magalhães C, Unsal E,
Oliveira S, Bracaglia C, Bagga A, Stanevicha V, Magni Manzoni S, Pratsidou P, Lepore L, Espada
G, Kone Paut I, Zulian F, Barone P, Bircan Z, del Rocio Maldonado M, Russo R, Vilca I, Tullus K,
Cimaz R, Horneff G, Anton J, Garay S, Nielsen S, Barbano G, Martini A. The
EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa,
childhood Wegener granulomatosis, and childhood Takayasu arteritis: ankara 2008. Part I: overall
methodology and clinical characterisation.
Ann Rheum Dis 2010;69:790-797
Ozen S, Pistorio A, Iusan SM, Bakkaloglu A, Herlin T, Brik R, Buoncompagni A, Lazar C, Bilge I,
Uziel Y, Rigante D, Cantarini L, Hilario MO, Silva CA, Alegria M, Norambuena X, Belot A,
Berkun Y, Amparo Ibanez E, Olivieri AN, Alpigiani MG, Rumba I, Sztajnbok F, Tambic-Bukovac
L, Breda L, Al-Mayouf S, Mihaylova D, Chasnyk V, Sengler C, Klein-Gitelman M, Djeddi D,
Nuno L, Pruunsild C, Brunner J, Kondi A, Pagava K, Pederzoli S, Martini A, Ruperto N. The
EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa,
childhood Wegener granulomatosis, and childhood Takayasu arteritis: ankara 2008. part ii: final
classification criteria.
Ann Rheum Dis 2010;69:798-806
Damasio MB , Malattia C, Martini A, Tomà P. Synovial and inflammatory diseases in childhood:
role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis.
Pediatr Radiol 2010;40:985-98
Ruperto N, Lovell DJ, Quartier P, Paz E, Rubio-Pérez N, Silva CA, Abud-Mendoza C, BurgosVargas R, GerloniV, Melo-Gomes JA, Saad-Magalhães C, Chavez J, Huemer C, Kivitz A, Blanco
FJ, Foeldvari I, Hofer M, Horneff G, Huppertz H-I, Job Deslandre C, Loy A, Minden K, Punaro M,
Flores Nunez A, Siga LH, Block AJ, Nys M, Martini A, Giannini EH. Long-Term Safety and
Efficacy of Abatacept in Children with Juvenile Idiopathic Arthritis
Arthritis Rheum 2010;62:1792–1802
Filocamo G, Davì S, Pistorio A, Bertamino M, Ruperto N, Lattanzi B, Consolaro A, Magnimanzoni S, Galasso R, Varnier GC, Martini A, Ravelli A. Evaluation of 21-Numbered Circle and
10-Centimeter Horizontal Line Visual Analog Scales for Physician and Parent Subjective Ratings in
Juvenile Idiopathic Arthritis
J Rheumatol 2010;37:1534-41
Cassani B, Poliani PG, Marrella V, Schena F, Sauer AV, Ravanini M, Strina D, Busse CE,
Regenass S, Wardemann H, Martini A, Facchetti F, van der Burg M, Rolink AG, Vezzoni P,
Grassi F, Traggiai E, Villa A. Homeostatic expansion of autoreactive immunoglobulin secreting
cells in the Rag2 mouse model of Omenn syndrome.
J Exp Med 2010;207:1525-40
Martini A, Lovell DJ. Juvenile idiopathic arthritis. State of the art and future perspectives
Ann Rheum Dis 2010;69:1260-3
Ruperto N, Bazso A, Pistorio A, Ravelli A, Filocamo G, Hernandez Huirache AH, Rodriguez
Lozano A, Pringe A, Vilca I, Martini A, Agreement between multi-dimensional and renal-specific
response criteria in patients with juvenile systemic lupus erythematosus.
Clin Exp Rheumatol 2010;28:424-33
Lepore L, Paloni G, Caorsi R, Alessio M, Rigante D, Ruperto N, Cattalini C, Tommasini A,
Zulian F, Ventura A, Martini A, Gattorno M. Long term follow-up and quality of life of patients
with cryopyrin associated periodic syndromes: efficacy and tolerabily of anakinra treatment.
J Pediatr 2010;157:310-315
Tassia S, Carta S, Delfino L, Caorsi R, Martini A, Gattorno M,Rubartelli A. Altered redox state of
monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion
Proc Natl Acad Sci U S A 2010;107:9789-94
Caorsi R, Pelagatti MA, Federici S, Finetti M, Martini A, Gattorno M. Periodic fever, apthous
stomatitis, pharyngitis and adenitis syndrome.
Curr Opin Rheumatol 2010;22:579-84
Filocamo G, Schiappapietra B, Bertamino M, Pistorio A, Ruperto N, Magni-Manzoni S, Lanni S,
Saad-Magalhaes C, Galasso R, Lattanzi B, Muratore V, Tani D, Martini A, Ravelli A.
A new short and simple health-related quality of life measure for paediatric rheumatic diseases:
initial validation in juvenile idiopathic arthritis
Rheumatology 2010;49:1272-80.
Vilca1 I, Garcia Munitis P, Pistorio A, Ravelli A, Buoncompagni A, Bica B, Campos L, Häfner R,
Hofer M, Ozen S, Huemer C, Cheol Bae S, Sztajnbok F, Arguedas O, Foeldvari I, Huppertz HI,
Gamir ML, Magnusson B, Dressler F, Uziel Y,. van Rossum MAJ, Hollingworth P, Cawkwell G,
Martini A, Ruperto N. Predictors of poor response to methotrexate in polyarticular-course juvenile
idiopathic arthritis. analysis of the printo methotrexate trial.
Ann Rheum Dis 2010;69:1479-83
Ruperto N, Pistorio A, Ravelli A, Rider L, Pilkington C, Oliveira S, Wulffraat N, Espada G, Garay
S, Cuttica R, Hofer M, Quartier P, Melo-Gomes J, Reed AM, Wierzbowska M, Feldman BM,
Harjacek M, Huppertz H-I, Nielsen S, Flato B, Lahdenne P, Michels H, Murray KJ, Punaro L,
Rennebohm R, Russo R, Balogh Z, Rooney M, Pachman LM, Wallace C, Hashkes P, Lovell DJ,
Giannini EH, Martini A. The PRINTO provisional criteria for the evaluation of response to therapy
in juvenile dermatomyositis.
Arthritis Care Res 2010;62:1533–1541
Visvanathan S, Wagner C, Marini JC, Lovell DJ, Martini A, Petty R, Cuttica R, Woo P, Espada G,
Gattorno M, Apaz MT, Baildam E, Fasth A, Gerloni V, Lahdenne P, Quartier P, Saurenmann R,
Travers S, Mendelsohn A, Xu S, Giannini EH, Ruperto N. The effect of infliximab plus
methotrexate on the modulation of inflammatory disease markers in juvenile idiopathic arthritis:
analyses from a randomized, placebo-controlled trial
Pediatr Rheumatol 2010, 8:24 doi:10.1186/1546-0096-8-24
Schena F, Gambini C, Gregorio A, Mosconi M, Reverberi D, Gattorno M, Casazza S, Uccelli A,
Moretta L, Martini A, Traggiai E. IFN-gamma dependent inhibition of B cell activation by bone
marrow derived mesenchymal stem cells in a murine model of systemic lupus erythematosus.
Arthritis Rheum 2010;62:2776-86
Ruperto N, Lovell DJ, Li T, Sztajnbok F, Goldenstein-Schainberg C, Scheinberg M, Calvo Penades
I, Fischbach M, Orozco J, Hashkes PJ, Hom C, Jung L, Lepore L, Oliveira S, Wallace C, Alessio
M, Bader Meunier B, Cortis E, Eberhard A, Simonini G, Lemelle I, Olson N, Chalom E, Sigal L,
Block A, Covucci A, Nys M, Martini A, Giannini EG. Abatacept improves health-related quality
of life, pain, sleep quality and activity participation in subjects with juvenile idiopathic arthritis
Arthritis Care Res 2010;62:1542–1551
Visvanathan S, Wagner C, Marini JC, Lovell DJ, Martini A, Petty R, Cuttica R, Woo P, Espada G,
Gattorno M, Apaz MT, Baildam E, Fasth A, Gerloni V, Lahdenne P, Quartier P, Saurenmann R,
Travers S, Mendelsohn A, Xu S, Giannini EH, Ruperto N. The effect of infliximab plus
methotrexate on the modulation of inflammatory disease markers in juvenile idiopathic arthritis:
analyses from a randomized, placebo-controlled trial.
Pediatr Rheumatol Online J. 2010 Sep 7;8(1):24
Bonaccorsi I, Cantoni C, Carrega P, Oliveri D, Lui G, Conte R, Navarra M, Cavaliere R, Traggiai
E, Gattorno M, Martini A, Mingari MC, Moretta A, Ferlazzo G. The Immune Inhibitory Receptor
LAIR-1 Is Highly Expressed by Plasmacytoid Dendritic Cells and Acts Complementary with
NKp44 to Control IFNα Production.
PLoS One. 2010 Nov 30;5(11):e15080
Ruperto N, Giannini EH, Pistorio A, Brunner HI, Martini A, Lovell DJ. Is it time to move to active
comparator trials in juvenile idiopathic arthritis?: a review of current study designs.
Arthritis Rheum. 2010;62:3131-9.
Gattorno M, Martini A. Treatment of Autoinflammatory sindromes.
Curr Opin Pediatr. 2010;22:771-8
Scott S, Meiorin S, Filocamo G, Lanni S, Valle M, Martinoli C, Martini A, Ravelli A. A
reappraisal of intra-articular corticosteroid therapy in juvenile idiopathic arthritis
Clin Exp Rheumatol 2010;28:774-81
Ravelli A, Varnier GC, Oliveira S, Castell E, Arguedas O, Magnani A, Pistorio A, Ruperto N,
Magni-Manzoni S, Galasso R, Lattanzi B, Dalprà S, Battagliese A, Verazza S, Allegra M, Martini
A. Antinuclear antibody positive patients should be grouped as a separate category in the
classification of juvenile idiopathic arthritis.
Arthritis Rheum. 2011;63:267-75.
Ruperto N, Martini A. Juvenile idiopathic arthritis, treatment and (possible) risk of malignancies
Nat Rev Rheumatol. 2011;7::6-7
Guseinova D, Consolaro A, Trail L, Ferrari C, Pistorio A, Ruperto N, Buoncompagni A, Pilkington
C, Maillard S, Oliveira SK, Sztajnbok F, Cuttica R, Corona F, Katsicas MM, Russo R, Ferriani V,
Burgos-Vargas R, Solis-Vallejo E, Bandeira M, Baca V, Saad-Magalhaes C, Silva CA, Barcellona
R, Breda L, Cimaz R, Gallizzi R, Garozzo R, Martino S, Meini A, Stabile A, Martini A, Ravelli A.
Comparison of clinical features and drug therapies among European and Latin American patients
with juvenile dermatomyositis.
Clin Exp Rheumatol. 2011;29:117-24
Piram M, Frenkel J, Gattorno M, Ozen S, Lachmann HJ, Goldbach-Mansky R, Hentgen V, Neven
B, Stankovic Stojanovic K, Simon A, Kuemmerle-Deschner J, Hoffman H, Stojanov S, Duquesne
A, Pillet P, Martini A, Pouchot J, Koné-Paut I. A preliminary score for the assessment of disease
activity in hereditary recurrent fevers: results from the aidai (auto-inflammatory diseases activity
index) consensus conference
Ann Rheum Dis 2011;70:309-14
Ruperto N, Pistorio A, Ravelli A, Hasija R, Guseinova D, Filocamo G, Demirkaya E, Malattia C,
Martini A. Criteria to define response to therapy in paediatric rheumatic diseases.
Eur J Clin Pharmacol. 2011;67 Suppl 1:125-31
Malattia C, Damasio MB, Pistorio A, Ioseliani M, Vilca I, Valle M, Ruperto N, Viola S,
Buoncompagni A, Magnano GM, Ravelli A, Tomà P, Martini A. Development and preliminary
validation of a pediatric-targeted MRI scoring system for the assessment of disease activity and
damage in juvenile idiopathic arthritis.
Ann Rheum Dis 2011;70:440-6
Borghini S, Tassi S. Chiesa S, Caroli F, Carta S., Caorsi R, Fiore M, , Delfino L, Lasigliè D,
Ferraris C, Traggiai E, Di Duca M. Tosca M, Martini A , Ceccherini I, Rubartelli A, Gattorno M.
Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with
recurrence of a NLRP12 mutation.
Arthritis Rheum 2011;63:830-9
Prigione I, Penco F, Martini A, Gattorno M, Pistoia V, Morandi F. HLA-G and HLA-E in patients
with juvenile idiopathic arthritis.
Rheumatology 2011;50:966-72
Pelagatti MA, Meini A, Caorsi R, Cattalini M, Federici S, Zulian F, Calcagno G, Tommasini A,
Bossi G, Sormani MP, 7 Caroli F, Plebani A, Ceccherini I, Martini A, Gattorno M. Long-term
follow up of children with the low penetrance R92Q mutation of TNFRSF1A gene
Arthritis Rheum 2011;63:1141-50
Filocamo G, Consolaro A, Schiappapietra B, Dalprà S, Lattanzi B, Magni-Manzoni S, Ruperto N,
Pistorio A, Pederzoli S, Civino A, Guseinova D, Masala E, Viola S, Martini A, Ravelli A.
A New Approach to Clinical Care of Juvenile Idiopathic Arthritis: The Juvenile Arthritis
Multidimensional Assessment Report.
J Rheumatol. 2011;38:938-53.
Ruperto N, Martini A. Networking in pediatrics: the example of the pediatric rheumatology
international trials organisation (PRINTO)
Arch Dis Child 2011;96:596-601
Davì S, Consolaro A, Guseinova D, Pistorio A, Ruperto N, Martini A, Cron RQ, Ravelli A. An
international consensus survey of diagnostic criteria for macrophage activation syndrome in
systemic juvenile idiopathic arthritis
J Rheumatol 2011;38:764-8
Beukelman T, Patkar NM, Saag KG, Tolleson-Rinehart S, Cron RQ, MD PhD1, DeWitt EM,
Ilowite NT, Kimura Y, Laxer RM, Lovell DJ, Martini A, Rabinovich E, Ruperto N. 2011
American College of Rheumatology recommendations for the treatment of juvenile idiopathic
arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and
systemic features.
Arthritis Care Res 2011;63:465-82
Lasigliè D, Traggiai E, Federici S, Alessio M, Buoncompagni A, Accogli A, Chiesa S, Penco F,
Martini A, Gattorno M. Role of IL-1 Beta in the Development of Human T(H)17 Cells: Lesson
from NLPR3 Mutated Patients.
PLoS One. 2011;6(5):e20014.
Prakken B, Albani S, Martini A. Juvenile idiopathic arthritis.
Lancet 2011;377:2138-49
Borghini S, Fiore M, Di Duca M, Caroli F, Finetti M, Santamaria G, Ferlito F, Bua F, Picco P,
Obici L, Martini A, Gattorno M, Ceccherini I. Candidate Genes in Patients with Autoinflammatory
Syndrome Resembling Tumor Necrosis Factor Receptor-associated Periodic Syndrome Without
Mutations in the TNFRSF1A Gene.
J Rheumatol. 2011;38:1378-84.
Hasija R, Pistorio A, Ravelli A, Demirkaya E,Khubchandani R, Guseinova D, Malattia C, Canhao
H, Harel L, Foell D, Wouters C, De Cunto C, Huemer C, Kimura Y, Mangge H, Minetti C, Nordal
EB, Philippet P, Garozzo R, Martini A, Ruperto N. Therapeutic approaches in the treatment of
juvenile dermatomyositis in patients with recent-onset disease and in those experiencing disease
flare: an international multicenter PRINTO study.
Arthritis Rheum 2011;63:3142-52
Consolaro A, Ruperto N, Pistorio A, Lattanzi B, Solari N, Galasso R, Pederzoli S, Varnier GC,
Dolezalova P, Alessio M, Burgos-Vargas R, Vesely R, Martini A, Ravelli A.Development and
initial validation of composite parent and child centered disease assessment indices for juvenile
idiopathic arthritis.
Arthritis Care Res 2011;63:1262-70
Lattanzi B, Consolaro A, Solari N, Ruperto N, Martini A, Ravelli A. Measures of disease activity
and damage in pediatric sistemi lupus erythematosus.
Arthritis Care Res 2011;63(S11):S112-S117.
Ravelli A, Martini A. Reply [Reply to letter].
Arthritis Rheum 2011;63:2835-6.
Lanni S, Bertamino M, Consolaro A, Pistorio A, Magni-Manzoni S, Galasso R, Lattanzi B, CalvoAranda E, Martini A, Ravelli A. Outcome and predicting factors of single and multiple intraarticular corticosteroid injections in children with juvenile idiopathic arthritis.
Rheumatology 2011;50:1627-34
Ruperto N, Martini A. Emerging drugs to treat juvenile idiopathic arthritis.
Expert Opin Emerg Drugs. 2011;16:493-505
Ardissone V, Radaelli E, Zaratin P, Ardizzone M, Ladel C, Gattorno M, Martini A, Grassi F,
Traggiai E. Pharmacological purinergic P2X antagonism in the treatment of experimental collageninduced arthritis.
Arthritis Rheum 2011;63:3323-32
Ruperto N, Martini A. Current medical treatments for juvenile idiopathic arthritis.
Front Pharmacol. 2011;2:60
Ruperto N, Carozzino L, Jamone R, Freschi F, Picollo G, Zera M, Della Casa Alberighi O,
Salvatori E, Del Vecchio A, Dionisio P, Martini A. A randomized, double-blind, placebocontrolled trial of paracetamol and ketoprofren lysine salt for pain control in children with
pharyngotonsillitis cared by family pediatricians.
Ital J Pediatr. 2011 Sep 29;37:48
Ravelli A, Lattanzi B, Consolaro A, Martini A. Glucocorticoids in paediatric rheumatology.
Clin Exp Rheumatol. 2011;29(5 Suppl 68):S148-52
Brisca G, Di Rocco M, Picco P, Damasio MB, Martini A. Coxarthritis as the presenting symptom
of Gaucher disease type 1.
Arthritis. 2011;2011:361279.
Rygg M, Pistorio A, Ravelli A, Maghnie M, Di Iorgi N, Bader-Meunier B, Da Silva C, RoldanMolina R, Barash J, Dracou C, Gandom Laloum S, Jarosova K, Job Deslandre C, Kone-Paut I,
Garofalo F, Press J, Sengler C, Tauber T, Martini A, RupertoN. A longitudinal printo study on
growth and puberty in juvenile systemic lupus erythematosus.
Ann Rheum Dis 2012;71:511-517
Ruperto N, Quartier P, Wulffraat N, Woo P, Ravelli A, Mouy R, Bader-Meunier B, Vastert SJ,
Noseda E, D’Ambrosio D, Lecot J, Chakraborty A, Martini A, Chioato A. A Phase II Study to
Evaluate Dosing and Preliminary Safety and Efficacy of Canakinumab in Systemic Juvenile
Idiopathic Arthritis With Active Systemic Features.
Arthritis Rheum 2012;64:557-67
Martini A. JIA in 2011: New takes on categorization and treatment.
Nat Rev Rheumatol. 2012;8:67-8
Consolaro A, Bracciolini G, Ruperto N, Pistorio A, Magni-Manzoni S, Malattia C, Pederzoli S,
Davì S, Martini A, Ravelli A. Remission, minimal disease activity and acceptable symptom state in
juvenile idiopathic arthritis.
Arthritis Rheum. 2012 Jul;64(7):2366-74
Filocamo G, Consolaro A, Schiappapietra B, Ruperto N, Pistorio A, Solari N, Pederzoli S, Verazza
S, Martini A, Ravelli A. Parent and Child Acceptable Symptom State in Juvenile Idiopathic
Arthritis.
J Rheumatol. 2012;39:856-63
Toplak N, Frenkel J, Ozen S, Lachmann HJ, Woo P, Koné-Paut I, De Benedetti F, Neven B, Hofer
M, Dolezalova P, Kümmerle-Deschner J, Touitou I, Hentgen V, Simon A, Girschick H, Rose C,
Wouters C, Vesely R, Arostegui J, Stojanov S, Ozgodan H, Martini A, Ruperto N, Gattorno M. An
International registry on Autoinflammatory diseases: the Eurofever experience.
Ann Rheum Dis. 12 Jul;71(7):1177-82
Hansson MG, Gattorno M, Forsberg JS, Feltelius N, Martini A, Ruperto N. Ethics bureaucracy: a
significant hurdle for collaborative follow-up of drug effectiveness in rare childhood diseases.
Arch Dis Child. 2012 Jun;97(6):561-3
Martini A. It is time to rethink juvenile idiopathic arthritis classification and nomenclature.
Ann Rheum Dis 2012 Sep;71(9):1437-9
Federici S, Calcagno G, Finetti M, Gallizzi R, Meini A, Vitale A, Caroli F, Cattalini M, Caorsi R,
Zulian F, Tommasini A, Insalaco A, Sormani MP, Baldi M, Ceccherini I, Martini A, Gattorno M.
Clinical impact of MEFV mutations in children with periodic fever in a prevalent western European
Caucasian population.
Ann Rheum Dis. 2012 Dec;71(12):1961-5
Malattia C, Damasio MB, Basso C, Santoro M, Verri A, Pederzoli S, Mattiuz C, Viola S,
Buoncompagni A, Madeo A, Mazzoni M, Rosendahl K, Lambot-Juhan K, Tanturri L, Magnano G,
Ravelli A, Martini A. A novel automated system for MRI quantification of the inflamed synovial
membrane volume in patients with juvenile idiopathic arthritis.
Arthritis Care Res 2012 Nov;64(11):1657-64
Demirkaya E, Ozen S, Pistorio A, Galasso R, Ravelli A, Hasija R, Baskin E, Dressler F, Fischbach
M, Garcia Consuegra J, Iagaru N, Pasic S, Scarpato S, van Rossum MAJ, Apaz MT, Barash J,
Calcagno G, Gonzalez B, Hoppenreijs E, Ioseliani M, Mazur-Zielinska H, Vougiouka O, Wulffraat
N, Luqmani R, Martini A, Ruperto N, Dolezalova P. Performance of the Birmingham Vasculitis
Activity Score and Disease Extent Index in childhood vasculitides.
Clin Exp Rheumatol 2012;30(Suppl. 70):S162-168
Gerss J, Roth J, Holzinger D, Ruperto N, Wittkowski H, Frosch M, Wulffraat N, Wedderburn L,
Stanevicha V, Mihaylova D, Harjacek M, Len C, Toppino C, Masi M, Minden K, Saurenmann T,
Uziel Y, Vesely R, Apaz MT, Kuester RM, Elorduy MJ, Burgos-Vargas R, Ioseliani M, MagniManzoni S, Unsal E, Anton J, Balogh Z, Hagelberg S, Mazur-Zielinska H, Tauber T, Martini A,
Foell D. Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for
a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study.
Ann Rheum Dis. 2012 Dec;71(12):1991-1997
Carta S, Tassi S, Delfino L, Omenetti A, Raffa S, Torrisi MR, Martini A, Gattorno M, Rubartelli
A. Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in
cryopyrin-associated periodic syndrome monocytes.
Ann Rheum Dis. 2012 Sep;71(9):1577-81.
Bertsias GK, Tektonidou M, Amoura Z, Aringer M, Bajema I, Berden JH, Boletis J, Cervera R,
Dörner T, Doria A, Ferrario F, Floege J, Houssiau FA, Ioannidis JP, Isenberg DA, Kallenberg CG,
Lightstone L, Marks SD, Martini A, Moroni G, Neumann I, Praga M, Schneider M, Starra A, Tesar
V, Vasconcelos C, van Vollenhoven RF, Zakharova H, Haubitz M, Gordon C, Jayne D, Boumpas
DT. Joint European League Against Rheumatism and European Renal Association-European
Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management
of adult and paediatric lupus nephritis.
Ann Rheum Dis. 2012 Nov;71(11):1771-82
Damasio MB, Malattia C, Tanturri de Horatio L, Mattiuz C, Pistorio A, Bracaglia C, Barbuti D,
Boavida P, Juhan KL, Ording LS, Rosendahl K, Martini A, Magnano G, Tomà P. MRI of the wrist
in juvenile idiopathic arthritis: proposal of a paediatric synovitis score by a consensus of an
international working group. Results of a multicentre reliability study.
Pediatr Radiol. 2012 Sep;42(9):1047-55
Spencer CH, Martini A. The growth of Pediatric Rheumatology: Pediatric Rheumatology European
Society and the impact factor.
Pediatr Rheumatol Online J. 2012 Jul 24;10(1):19.
Martini A. Systemic juvenile idiopathic arthritis.
Autoimmun Rev. 2012 Nov;12(1):56-9.
Ter Haar N, Lachmann H, Ozen S, Woo P, Uziel Y, Modesto C, Koné-Paut I, Cantarini L, Insalaco
A, Neven B, Hofer M, Rigante D, Al-Mayouf S, Touitou I, Gallizzi R, Papadopoulou-Alataki E,
Martino S, Kuemmerle-Deschner J, Obici L, Iagaru N, Simon A, Nielsen S, Martini A, Ruperto N,
Gattorno M, Frenkel J; Treatment of autoinflammatory diseases: results from the Eurofever
Registry and a literature review.
Ann Rheum Dis. 2012 Jun 29.
Malattia C, Consolaro A, Pederzoli S, Madeo A, Pistorio A, Mazzoni M, Mattiuz C, Magnano G,
Viola S, Buoncompagni A, Palmisani E, Hasija R, Ruperto N, Ravelli A, Martini A. MRI versus
conventional measures of disease activity and structural damage in evaluating treatment efficacy in
juvenile idiopathic arthritis.
Ann Rheum Dis. 2012 Jul 4. [Epub ahead of print]
Miettunen PM, Pistorio A, Palmisani E, Ravelli A, Silverman E, Oliveira S, Alessio M, Cuttica R,
Mihaylova D, Espada G, Pasic S, Insalaco A, Ozen S, Porras O, Sztajnbok F, Lazarevic D, Martini
A, Ruperto N. Therapeutic approaches for the treatment of renal disease in juvenile systemic lupus
erythematosus: an international multicentre PRINTO study.
Ann Rheum Dis. 2012 Oct 25. [Epub ahead of print]
Bachetti T, Chiesa S, Castagnola P, Bani D, Di Zanni E, Omenetti A, D'Osualdo A, Fraldi A,
Ballabio A, Ravazzolo R, Martini A, Gattorno M, Ceccherini I. Autophagy contributes to
inflammation in patients with TNFR-associated periodic syndrome (TRAPS).
Ann Rheum Dis. 2012 Oct 31. [Epub ahead of print]
Consolaro A, Negro G, Lanni S, Solari N, Martini A, Ravelli A. Toward a treat-to-target approach
in the management of juvenile idiopathic arthritis.
Clin Exp Rheumatol. 2012 Oct 16. [Epub ahead of print]
Lazarevic D, Pistorio A, Palmisani E, Miettunen P, Ravelli A, Pilkington C, Wulffraat NM,
Malattia C, Garay SM, Hofer M, Quartier P, Dolezalova P, Penades IC, Ferriani VP, Ganser G,
Kasapcopur O, Melo-Gomes JA, Reed AM, Wierzbowska M, Rider LG, Martini A, Ruperto N.
The PRINTO criteria for clinically inactive disease in juvenile dermatomyositis.
Ann Rheum Dis. 2012 Jun 26. [Epub ahead of print]
Solari N, Palmisani E, Consolaro A, Pistorio A, Viola S, Buoncompagni A, Gattorno M, Picco P,
Ruperto N, Malattia C, Martini A, Ravelli A. Factors Associated with Achievement of Inactive
Disease in Children with Juvenile Idiopathic Arthritis Treated with Etanercept.
J Rheumatol. 2012 Dec 1. [Epub ahead of print]
Consolaro A, Ruperto N, Filocamo G, Lanni S, Bracciolini G, Garrone M, Scala S, Villa L,
Silvestri G, Tani D, Zolesi A, Martini A, Ravelli A. Seeking insights into the EPidemiology,
treatment and Outcome of Childhood Arthritis through a multinational collaborative effort:
Introduction of the EPOCA study.
Pediatr Rheumatol Online J. 2012 Nov 20;10(1):39.
De Benedetti F, Brunner HI, Ruperto N, Kenwright A, Wright S, Calvo I, Cuttica R, Ravelli A,
Schneider R, Woo P, Wouters C, Xavier R, Zemel L, Baildam E, Burgos-Vargas R, Dolezalova P,
Garay SM, Merino R, Joos R, Grom A, Wulffraat N, Zuber Z, Zulian F, Lovell D, Martini A
Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis.
N Engl J Med. 2012;367:2385-95.
Ruperto N*, Brunner HI*, Quartier P, Constantin T, Wulffraat N, Horneff G, Brik R, McCann L,
Kasapcopur O, Rutkowska-Sak L, Schneider R, Berkun Y, Calvo I, Erguven M, Goffin L, Hofer M,
Kallinich T, Oliveira SK, Uziel Y, Viola S, Nistala K, Wouters C, Cimaz R, Ferrandiz MA, Flato B,
Gamir ML, Kone-Paut I, Grom A, Magnusson B, Ozen S, Sztajnbok F, Lheritier K, Abrams K, Kim
D, Martini A*, Lovell DJ*. (* equally contributed). Two randomized trials of canakinumab in
systemic juvenile idiopathic arthritis.
N Engl J Med. 2012;367:2396-406.
Papadopoulou C, Kostik M, Gonzalez-Fernandez MI, Bohm M, Nieto-Gonzalez JC, Pistorio A,
Lanni S, Consolaro A, Martini A, Ravelli A. Delineating the role of multiple intra-articular
corticosteroid injections in the management of juvenile idiopathic arthritis in the biologic era.
Arthritis Care Res 2013 Jan 17 [Epub ahead of print]
Mina R, Klein-Gitelman MS, Nelson S, Eberhard BA, Higgins G, Singer NG, Onel K, Tucker L,
O'Neil KM, Punaro M, Levy DM, Haines K, Martini A, Ruperto N, Lovell D, Brunner HI.
Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic
lupus erythematosus.
Ann Rheum Dis. 2013 Jan 23. [Epub ahead of print]
Caorsi R, Lepore L, Zulian F, Alessio M, Stabile A, Insalaco A, Finetti M, Battagliese A, Martini
G, Bibalo C, Martini A, Gattorno M. The schedule of administration of canakinumab in cryopyrin
associated periodic syndrome is driven by the phenotype severity rather than the age.
Arthritis Res Ther. 2013 Feb 26;15(1):R33. [Epub ahead of print]
Cangemi G, Pistorio A, Miano M, Gattorno M, Acquila M, Bicocchi MP, Gastaldi R, Riccardi F,
Gatti C, Fioredda F, Calvillo M, Melioli G, Martini A, Dufour C. Diagnostic potential of hepcidin
testing in pediatrics.
Eur J Haematol. 2013 Feb 26. doi: 10.1111/ejh.12081. [Epub ahead of print]
Gattorno M, Martini A. Beyond the NLRP3 inflammasome: Autoinflammatory diseases reach
adolescence.
Arthritis Rheum. 2013 Feb 11. doi: 10.1002/art.37882. [Epub ahead of print]
Ozen S, Demirkaya E, Amaryan G, Koné-Paut I, Polat A, Woo P, Uziel Y, Modesto C, Finetti M,
Quartier P, Papadopoulou-Alataki E, Al-Mayouf SM, Fabio G, Gallizzi R, Cantarini L, Frenkel J,
Nielsen S, Hofer M, Insalaco A, Acikel C, Ozdogan H, Martini A, Ruperto N, Gattorno M. Results
from a multicentre international registry of familial Mediterranean fever: impact of environment on
the expression of a monogenic disease in children.
Ann Rheum Dis. 2013 Mar 5. [Epub ahead of print]
Malattia C, Consolaro A, Pederzoli S, Madeo A, Pistorio A, Mazzoni M, Mattiuz C, Magnano G,
Viola S, Buoncompagni A, Palmisani E, Hasija R, Ruperto N, Ravelli A, Martini A. MRI versus
conventional measures of disease activity and structural damage in evaluating treatment efficacy in
juvenile idiopathic arthritis.
Ann Rheum Dis. 2013 Mar;72(3):363-8
Omenetti A, Carta S, Delfino L, Martini A, Gattorno M, Rubartelli A. Increased NLRP3-dependent
interleukin 1β secretion in patients with familial Mediterranean fever: correlation with MEFV
genotype.
Ann Rheum Dis. 2013 Mar 16. [Epub ahead of print]
Picco P, Naselli A, Pala G, Marsciani A, Buoncompagni A, Martini A. Recurrent Pericarditis in
Myhre Syndrome.
Am J Med Genet A. 2013 Mar 20
Horneff G, Burgos-Vargas R, Constantin T, Foeldvari I, Vojinovic J, Chasnyk VG, Dehoorne J,
Panaviene V, Susic G, Stanevica V, Kobusinska K, Zuber Z, Mouy R, Rumba-Rozenfelde I, Breda
L, Dolezalova P, Job-Deslandre C, Wulffraat N, Alvarez D, Zang C, Wajdula J, Woodworth D,
Vlahos B, Martini A, Ruperto N. Efficacy and safety of open-label etanercept on extended
oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1
(week 12) of the CLIPPER study.
Ann Rheum Dis. 2013 May 21. [Epub ahead of print]
Papadopoulou C, Kostik M, Böhm M, Nieto-Gonzalez JC, Gonzalez-Fernandez MI, Pistorio A,
Martini A, Ravelli A. Methotrexate Therapy May Prevent the Onset of Uveitis in Juvenile
Idiopathic Arthritis.
J Pediatr. 2013 May 9 [Epub ahead of print]
Malattia C, Damasio MB, Madeo A, Pistorio A, Providenti A, Pederzoli S, Viola S, Buoncompagni
A, Mattiuz C, Beltramo A, Consolaro A, Ravelli A, Ruperto N, Picco P, Magnano GM, Martini A.
Whole-body MRI in the assessment of disease activity in juvenile dermatomyositis.
Ann Rheum Dis. 2013 May 1. [Epub ahead of print]