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Bibliometric Analysis of the FP7 High Impact Project on Advanced Immunization Technologies November 2015 EXECUTIVE SUMMARY A highly innovative project was launched October 1, 2011 to develop new vaccination strategies: ADITEC (Advanced Immunization Technologies). This project, funded through the 7th Framework Programme of the European Union, aims to accelerate the development of novel and powerful immunization technologies for the next generation of human vaccines. Scientists from 43 partner institutions in 13 different countries collaborate in the ADITEC project. This report presents an analysis performed by ADITEC management on publications resulting from research funded by the ADITEC project and bearing the ADITEC funding acknowledgement. The number of citations, as well as Journal Impact Factors (JIF) were used as an indicators of research quality and co-authorship as an index of collaboration. This information was gathered using Scopus and in few occasions, Publish or Perish in addition to SCImago Journal & Country Rank. HIGH NUMBER OF ADITEC PUBLICATIONS To date, ADITEC projects have produced 148 publications. The number of publications with an ADITEC project acknowledgement has increased each year since the beginning of the project in 2012. This trend is to be expected to continue as the project gets underway and new data becomes available. ADITEC PUBLICATIONS ARE OF HIGH QUALITY 88 % of papers were published in journal with impact factors in Quartile 1 of their respective subject categories. The total Journal Impact Factor (JIF) of all ADITEC publications is 1010 with an average of 7.21. The highest JIF was 54.42. Page 1 ADITEC PROJECT RESEARCH IS HIGHLY CITED The quality of ADITEC funded research, as measured by raw number of citations, has been maintained while output has grown. The raw citation impact of ADITEC project research publications is 1645 in four years with and average number of 11.1 citations per paper. ADITEC PROMOTES PARTNERSHIPS Research funded through the ADITEC project is highly collaborative. About 72% of all ADITEC publications were cross-sector (for example, between academic institutions and the governmental organizations). 23% involved multiple ADITEC project partners and 69% involved multiple organizations. 30 countries were represented in author affiliations. KEY FINDINGS FROM THE ANALYSIS As many published articles are still quite recent, the full impact of the research is not yet identifiable. Over the next months and years as dissemination grows, the impact of this project’s research will continue to grow beyond the numbers we see today. ADITEC has published a total of 148 unique publications to date and continues to show substantial growth. Research publications/year increased between 2012 and 2015, with a 50% increase from 2012 to 2013 and then a 67% increase from ’13 to 2014. (Data on 2015 through September only.) # Publications per Year 60 50 40 30 20 10 55 38 2014 2015 33 22 0 2012 2013 Page 2 ADITEC publications appeared in 74 different peer reviewed journals. The total Journal Impact Factor (JIF) of all ADITEC publications is 1010 with an average of 7.21. Number of Articles Published and Title of Journals 1 1 1 1 1 1 2 3 2 2 2 2 1 1 1 6 2 1 1 1 3 5 1 2 1 1 1 1 1 1 1 1 2 5 1 New England J Medicine Nature Nature Reviews Immunology Cell Nature Biotechnology Nature Reviews: Microbiology Immunity Journal of Experimental Medicine J Clinical Investigation Immunological Reviews Cell Host Microbe Trends in Immunology American Journal of Respiratory and Critical Care Medicine Nature Protocols J. of Allery and Clinical Immunology PNAS Cold Spring Harbor Perspectives in Medicine PloS Pathogens Journal of Controlled Release Trends in Microbiology Current Opinion in Immunology Science Translational Medicine Current Opinion in Biotechnology Seminars in Immunology European Respiratory Society Monograph Molecular Therapy Mucosal Immunology AIDS Seminars in Immunopathology Retrovirology Arteriosclerosis, Thrombosis and Vascular Biology Nanomedicine J Internal Medicine J Infectious Disease Clinical Science Impact Factor 54.42 42.351 33.836 33.116 23.268 21.182 19.748 13.85 13.765 12.909 12.194 12.031 11.986 11.74 11.248 9.681 9.63 9.127 8.078 7.91 7.867 7.8 7.711 7.25 7.125 7.04 6.963 6.557 6.482 6.47 6.338 5.824 5.785 5.778 5.629 Page 3 7 2 2 2 1 2 2 1 17 2 2 1 2 15 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 7 1 Journal of Immunology J Virology European Journal of Immunology Journal of Biological Chemistry Biochimica et Biophys Acta Annals of the New York Academy of Sciences Expert Review of Vaccines Immunology and Cell Biology PloS one Infection and Immunity Applied and Environmental Microbiology Pharmaceutical Research Microbial Cell Factories Vaccine Immunobiology Cytometry Biogerontology Current Opinion in Pulmonary Medicine Journal of Biomedical Optics Molecular Immunology Lancet Respiratory Medicine Genes And Immunity International Journal of Tuberculosis and Lung Disease BMC Microbiology BMC Infectious Disease Tuberculosis (Edinb) Sensors International Archives of Allergy and Immunology Immunology Letters Archives of Dermatological Research J Vaccines and Vaccination Protein Expression and Purification Viral Immunology ASMscience Frontiers of Immunology EBioMedicine 5.52 5.076 4.97 4.773 4.66 4.375 4.217 4.147 4.092 4.074 3.952 3.952 3.55 3.458 3.205 3.066 3.01 2.957 2.945 2.917 2.917 2.913 2.731 2.73 2.56 2.54 2.457 2.433 2.367 1.902 1.8 1.695 1.636 unknown unknown unknown Page 4 Most ADITEC papers were published in journals with impact factors in Quartile 1 of their respective subject categories. Subject Category Quartile Counts Quartile 1 131 88% Quartile 2 12 7% Quartile 3 2 1% Quartile 4 2 1% ADITEC papers are highly-cited, with 1645 raw citations in four years for the 148 articles published to date with an average citation per paper of 11.1. The most cited article, cited 118 times, was published in 2012 in the Journal of Experimental medicine. 54% of all ADITEC publications appeared in open access journals. Number of Raw Citations per Year 57 2012 2013 315 2014 2015 1645 Total Citations 716 557 More than two-thirds (71%) of ADITEC papers were collaborative between institutions, with nearly a quarter of the published research resulting from collaborations of more than one ADITEC partner (24%). About 49% of all published research has resulted from international collaborations. Page 5 Over three-quarters (82%) of all ADITEC papers were published by researchers affiliated with more than one sector. Author Affiliations by Sector 120 academic 31 corp 69 govt 14 medical 33 other 0 50 100 150 Scientists from 30 different countries involved in authoring papers resulting from ADITEC sponsored research. Below is a diagram identifying the country affiliations of authors represented and the number of ADITEC publications affiliated with that country. Frequency and Distribution of ADITEC Collaborators Page 6 Scientific Publications Resulting From ADITEC Support 1. Andersen P and Joshua S. Woodworth Tuberculosis vaccines – rethinking the current paradigm Trends in Immunology , 35 (8) 387 - 395 DOI: 10.1016/j.it.2014.04.006 2. Andersen P, Urdahl K. TB vaccines; promoting rapid and durable protection in the lung. Curr Opin Immunol. 2015 Aug;35:55-62. doi: 10.1016/j.coi.2015.06.001. 3. Andersen, P., S. H.E. Kaufmann: Novel vaccination strategies against tuberculosis. Cold Spring Harb Perspect Med4(6): a018523. (2014), doi: 10.1101/cshperspect.a018523. 4. Bardelli M, Alleri L, et al. Ex Vivo Analysis of Human Memory B Lymphocytes Specific for A and B Influenza Hemagglutinin by Polychromatic Flow-Cytometry. PLoS ONE 8(8): e70620. (2013) doi:10.1371/journal.pone.0070620. 5. Boer MC, et al. CD8+ Regulatory T Cells, and Not CD4+ T Cells, Dominate Suppressive Phenotype and Function after In Vitro Live Mycobacterium bovis-BCG Activation of Human Cells. PLoS One. 9(4) :e94192;2014 DOI:10.1371/journal.pone.0094192 6. Boer, MC., et al, CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8+CD39+ regulatory T cells European Journal of Immunology 29 MAY 2013 DOI: 10.1002/eji.20124328. 7. Boianelli A, et al A A Stochastic Model for CD4+ T Cell Proliferation and Dissemination Network in Primary Immune Response PLoS One. 2015 Aug 24;10(8):e0135787. doi: 10.1371/journal.pone.0135787 8. Bøje S, et al. A multi-subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFNg+ CMI responses protects against a genital infection in minipigs. 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