Hugo L. Monaco Department of Biotechnology

CURRICULUM VITAE
Hugo L. Monaco
Department of Biotechnology – University of Verona –Strada le Grazie, 15 – 37134 Verona, Italy
Hugo L. Monaco (Ugo L.) received his first degree in Biochemistry from the University of Córdoba in Argentina.
In 1974 he was awarded an A.M. and in 1978 a Ph.D. in Chemistry by the Department of Chemistry of Harvard
University where he worked, first as a student and subsequently as a post doc., under the supervision of Prof.
William N. Lipscomb, Nobel Laureate in 1976. In 1980 he moved to Padua with a position of Research Officer
in the Italian National Research Council and, in 1987, to Pavia where he was appointed Associate Professor of
Structural Chemistry (Physical Chemistry). In 1991 he was appointed member of the Founding Committee of
the Faculty of Sciences of the University of Verona where, in October 2000, he was appointed Full Professor
of Molecular Biology. In Verona he teaches Physical Chemistry and Biocrystallography. His research fields are
Biochemistry and Biocrystallography and he is currently active in the field of hydrophobic molecule-binding
proteins, lectins, proteins with a role in tumor growth and protein macromolecular complexes.
Detailed C.V.
WORK EXPERIENCE:
From 1/10/2000 to now Full Professor of Molecular Biology - Dipartimento di Biotecnologie –
Università di Verona – Strada Le Grazie, 15, 37134 Verona, Italy.
From 1/10/1987 to 31/10/2000 Associate Professor of Structural Chemistry - Dipartimento di Genetica e Microbiologia
Università di Pavia – via Abbiategrasso , 207, 27100 Pavia, Italy.
From 1/1/1980 to 30/9/1987 Ricercatore (Research Officer, Italian National Research Council) - Dipartimento di Chimica Organica
Università di Padova – via Marzolo, 1, 35131 Padova, Italy.
From 1/9/1974 to 30/6/1977 Teaching Fellow in Chemistry - Department of Chemistry
Harvard University – 12 Oxford St., Cambridge, Ma 02138 U.S.A.
From 15/1/1968 to 31/8/1971 Ayudante Alumno (Teaching Fellow) Departamento de Fisico Quimica Universidad nacional de Córdoba - Haya de la Torre esq. Medina Allende, Ciudad Universitaria 5900 Córdoba, Argentina
EDUCATION AND TRAINING:
From 1/7/1978 to 31/12/1979 Post Doctoral Fellow Department of Chemistry
Harvard University – 12 Oxford St., Cambridge, Ma 02138 U.S.A.
From 1/9/1973 to 30/6/1978 Doctor of Philosophy in Chemistry. Dissertation on “The crystal structure of aspartate transcarbamylase to a
nominal resolution of 2.8 Å”. Research Advisor: Prof. William P. Lipscomb (Nobel Laureate 1976).
Harvard University – 12 Oxford St., Cambridge, Ma 02138 U.S.A.
From 1/9/1972 to 30/6/1973 Master of Arts in Chemistry
Harvard University – 12 Oxford St., Cambridge, Ma 02138 U.S.A
From 1/2/1965 to 31/12/1970 Bioquimico (approximately equivalent to an A.M. in Biochemistry).
Universidad nacional de Córdoba - Haya de la Torre esq. Medina Allende, Ciudad Universitaria 5900 Córdoba, Argentina
PERSONAL SKILLS AND COMPETENCES
MOTHER TONGUE: SPANISH
OTHER LANGUAGES
ITALIAN
Reading skills: excellent
ENGLISH
Reading skills: excellent
FRENCH
Reading skills: good
GERMAN
Reading skills: basic
Writing skills excellent
Writing skills excellent
Writing skills basic
Writing skills basic
Verbal skill:
Verbal skill:
Verbal skill:
Verbal skill:
excellent
excellent
basic
basic
SOCIAL SKILLS AND COMPETENCES
Invited seminar presentations classified by country.
Argentina
Universidad de Córdoba, 1976, 1979, 1987, 1997, 1999, 2005, 2006, 2011, 2013. Universidad de Buenos Aires, 1979. Main Lecture Meeting of the
Argentine Biochemical Society, 1987. Plenary Lecture Meeting of the Ibero-american Biophysical Society, 1997, Argentine Biophysical Society 2005, 2008,
2011. Plenary Lecture Meeting of the Latin American Crystallographic Association Cordoba, October 2013
Brasil
University of Sâo Paulo (Campus de Sâo Carlos), 1979
France
Institut Pasteur, Paris, 1989. Institut National de la Recherche Agronomique, Nantes, 1995
Germany
EMBO Laboratory, Heidelberg, 1980. EMBL Synchrotron Outstation, Hamburg, 1986
Italy
Università di Padova, 1979, 1980, 1981, 1984, 2010. Centro di Ricerche dell'Istituto Sclavo, Siena, 1983.
Spain
Instituto de Quimica Fisica "Rocasolano", Madrid, 1978. Universidad Autonoma de Barcelona, 1982, 1986
United States of America
Harvard University, 1979. Boston College, 1979. The Johns Hopkins University, School of Medicine, 1988, 1990, 1995,1997. Macromolecular
Crystallography Laboratory, Eli Lilly & Company, Indianapolis, 1997. University of California at San Diego 2002
Venezuela
Instituto Venezolano de Investigaciones Cientificas, Caracas, 1979, Universidad Simon Bolivar, Caracas, 1979
ORGANISATIONAL SKILLS AND COMPETENCES
Organization of meetings and other academic activities.
Member of the organizing committee of the meeting "Peptides, polypeptides and Proteins, Interactions and their Biological Implications" Galzignano
(Padova) June 20-27, 1982.
Member of the organizing committee of the "Fifth Italian-Yugoslav Crystallographic Congress" Padova June 3-6, 1986.
Organizer of the symposium on Biocrystallography for the meeting of the Italian Association of Crystallography, Genova, October 23-25, 1990.
Organizer of the "Second European Workshop on Crystallography of Biological Macromolecules”. Como, May 13-16, 1991.
Member of the organizing committee of the meeting "Proteine ‘92", on behalf of the Italian Biochemical Society. Pavia May 26-28, 1992.
Member of the National Committee judging the applicants for the tenured positions of Associate Professors in Structural Chemistry in Italy in the year 1990.
Member of the Instrumentation and Computing Committee of the Italian Association of Crystallography from 1990 to 1993.
Member of the Founding Committee of the Faculty of Mathematical Physical and Natural Sciences of the University of Verona.
Coordinator of the Ph.D. program in molecular, industrial and environmental Biotechnology from 2003 to 2009
Vice Dean of the Faculty of Sciences from 2006 to 2009.
Organizer of the 41th Congress of the Italian Crystallographic Association (AIC) September 2012.
Teaching activities in schools for graduate students and postdoctoral fellows.
Convegno Scuola sui Biopolimeri. Organized by the Italian Association for Science and Technology of Macromolecules, Gargnano, Italy 1984.
Atelier de Cristallization des Macromolecules Biologiques organized by the French CNRS, Marseille, France 1984.
Primera Escuela de Cristalografia Macromolecular organized by the Spanish National Research Council and the University of Barcelona, Barcelona, Spain
1986.
Second Basic EMBO Course - Modern Analysis of Biological Structures, Pavia, Italy 1986.
Scuola Nazionale di Scienze delle proteine organized by the Italian Biochemical Society, Siena, Italy, 1987, 1988,1989, 1990, 1994, 1996.
Scuola sui Metodi Sperimentali in Crystallografia organized by the Italian Association of Crystallography, Perugia, Italy, 1990, 1994, 1997.
Corso Pratico sui Metodi di Cristallizzazione di Proteine, organized by the Italian Biochemical Society, Pavia, 1991.
Corso di formazione in Biotecnologie, organized by Consorzio Siena Ricerche, Marina di Campo, Isola d'Elba,Italy,1992.
Corso di formazione in Ingegneria Proteica, organized by Tecnobiochip, Marciana Marina, Isola d'Elba, Italy,1992.
Scuola sulle Biotecnologie in Fisiologia vegetale, organized by the Italian Society of Vegetal Fisiology , Maratea,Italy,1997.
Ph. D. course in Biocrystallography. University of Cordoba, Argentina, August 1999
Workshop di cristallografia sperimentale ad Elettra, Trieste, Italy, October 2000
Insubria International Summer School: Crystallography for health and biosciences University of Insubria, Como, June,19 – 23 2012
OTHER SKILLS AND COMPETENCES
Author of the following book chapters
Hugo L. Monaco. "Experimental Methods in X-ray Crystallography" in "Fundamentals of Crystallography", edited by Carmelo Giacovazzo . Oxford University Press. (1992).
Hugo L. Monaco. "Time-Resolved Protein Crystallography" Proceedings of the International School of Physics "Enrico Fermi". Course CXXVII, E. Burattini & A. Balerna (eds)
IOS Press, Amsterdam 225- 234 (1996).
Hugo L. Monaco & Gilberto Artioli. "Experimental Methods in X-ray and Neutron Crystallography" in "Fundamentals of Crystallography" Second Edition, edited by Carmelo
Giacovazzo . Oxford University Press. (2002).
Hugo L. Monaco. "Odorant-binding proteins" in Wiley Encyclopedia of Molecular Medicine. Thomas E. Creighton ed. John Wiley & Sons, New York, pp. 2317-2320 (2002).
Hugo L. Monaco. "Riboflavin-binding protein" in Wiley Encyclopedia of Molecular Medicine. Thomas E. Creighton ed. John Wiley & Sons, New York, pp. 2807-2310 (2002).
Hugo L. Monaco. "The transthyretin-retinol-binding complex" in Recent advances in transthyretin evolution, structure and biological functions. . Samantha J. Richardson & Vivian
Cody ed. Springer, Berlin-Heidelberg, pp. 123-142 (2009).
ADDITIONAL INFORMATION
VISITING PROFFESORSHIPS:
The Johns Hopkins University, School of Medicine (Baltimore, MD USA) - February-March 1994.
Universidad Nacional de Córdoba (Argentina) - August-September 1999. June 2006.
PRIZES AND AWARDS
Premio Universidad - University of Córdoba 1971
Prize for Excellence in the teaching of Chemistry, Harvard University 1973
Distinguished visitor - University of Córdoba 1999
Premio Raices, Ministry of Science and Technology of Argentina awarded November 2013 “For contributions to International cooperation in
Science and Technology”.
Honorary member of the Argentine National Research Council (Investigador correspondiente) from June 2010 to now.
FIVE SELECTED PUBLICATIONS
Carrizo ME, Capaldi S, Perduca M, Irazoqui FJ, Nores GA, Monaco HL. (2005) The antineoplastic lectin of the common edible mushroom
(Agaricus bisporus) has two binding sites, each specific for a different configuration at a single epimeric hydroxyl. J Biol Chem. 2005 Mar
18;280(11):10614-10623.
Monaco HL. (1997) Crystal structure of chicken riboflavin-binding protein. EMBO J. 1997 Apr 1;16(7):1475-1483.
Monaco HL, Rizzi M, Coda A. (1995) Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science. 1995
May 19;268(5213):1039-1041.
Zanotti G, Berni R, Monaco HL. (1993) Crystal structure of liganded and unliganded forms of bovine plasma retinol-binding protein. J Biol
Chem. 1993 May 25;268(15):10728-10738.
Monaco HL, Crawford JL, Lipscomb WN. (1978) Three-dimensional structures of aspartate carbamoyltransferase from Escherichia coli and
of its complex with cytidine triphosphate. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5276-5280.
MOLECULES DISCOVERED
Bovi M, Cenci L, Perduca M, Capaldi S, Carrizo ME, Civiero L, Chiarelli LR, Galliano M, Monaco HL. (2013) BEL β-trefoil: a novel lectin with
antineoplastic properties in king bolete (Boletus edulis) mushrooms. Glycobiology. 2013 May;23(5):578-592.
Bovi M, Carrizo ME, Capaldi S, Perduca M, Chiarelli LR, Galliano M, Monaco HL. (2011) Structure of a lectin with antitumoral properties in
king bolete (Boletus edulis) mushrooms. Glycobiology. 2011 Aug;21(8):1000-1009.
Galliano M, Minchiotti L, Campagnoli M, Sala A, Visai L, Amoresano A, Pucci P, Casbarra A, Cauci M, Perduca M, Monaco HL. (2003)
Structural and biochemical characterization of a new type of lectin isolated from carp eggs. Biochem J. 2003 Dec 1;376(Pt 2):433-440.
Scapin G, Spadon P, Pengo L, Mammi M, Zanotti G, Monaco HL. (1988) Chicken liver basic fatty acid-binding protein (pI = 9.0). Purification,
crystallization and preliminary X-ray data. FEBS Lett. 1988 Nov 21;240(1-2):196-200.
ANNEX
For an almost complete and updated list of publications in international peer reviewed journals see
http://www.ncbi.nlm.nih.gov/pubmed?term=monaco+h