faraone mennella - Università degli Studi di Napoli Federico II

Group Leader
Maria Rosaria Faraone Mennella, Associate Professor of Biochemistry
Department of Structural and Functional Biology
Faculty of Sciences MM FF NN- University of Naples “Federico II”
Complesso Universitario di Monte S. Angelo
Building 7, Room 1F-35
Via Cinthia, 80126 Napoli (Italy)
Tel. +39081679136
Fax: +39081679233
[email protected]
Group members
Anna De Maio (senior researcher)
+39081679131; [email protected]
Elena Porzio (PhD student)
+39081679134; [email protected]
Carmela Mistretta (PhD student)
+39081679134; [email protected]
Emiliana Natale (post-doc fellow)
+39081679134; [email protected]
HONORARY MEMBER: Prof. BENEDETTA FARINA
+39081679132;
[email protected]
Key words (max 5)
Poly-ADP-ribosylation; NAD+; sulfolobales; octopus; biomarkers
Research projects
-PARP in Eukaryotes.
The ADP-ribosylation system in plants and animals (mammals and octopoda).
Relationship between enzyme(s) structure and function (chromatin organization, DNA
repair, signal transduction, etc.).
-PARP in Archaea.
The ADP-ribosylation system and its multiple roles in Sulfolobus solfataricus.
Evolutionary meaning and biotechnological interest.
-PARP and pathologies.
The ADP-ribosylation system as a tool for prognosis and / or diagnosis of
autoimmunity (Systemic lupus er.) and cancer (melanoma, pesticide-induced
tumors). Possibile therapeutic applications.
-Identification of other biomarkers.
To define advanced strategies for the early detection of biological damage and toxins
in human health and environmental defence.
- Oxidative stress through cis/trans isomerization of unsaturated phospholipids by
gamma-irradiation in the presence of sulfur-containing proteins.
Collaborations
Prof. Anna Di Cosmo and Prof. Amalia Virzo-De Santo
Sections of Zoology and Botany,
Department of Structural and Functional Biology - Faculty of Sciences MM FF NN University of Naples “Federico II” - 80126 Napoli (Italy)
Profs. Anna Cardone and Sergio Di Meo
Dipartimento delle Scienze Biologiche, Sezioni di Fisiologia e Biologia, Facoltà di
Scienze MM FF NN, Università degli studi di Napoli “Federico II”,80134 Naples (Italy)
Prof. Raffaele Scarpa
Dept. of Clinic and Experimental Medicine, Faculty of Medicine - University of Naples
“Federico II”
Prof. Gustavo Mita
Department of Experimental Medicine, Second University of Naples, (Italy)
Dr Giuseppe Calmieri
Unit of Cancer Genetics, Institute of Biomolecular Chemistry, C.N.R., Sassari, Italy
Prof. Paolo Ascierto
Clinical Immunology National Tumor Institute, Fondazione Pascale, Naples, Italy
Prof. Augusto Parente and Dr. Antimo Di Maro
Department of Life Sciences, Faculty of Sciences, Second University of Naples, 81100
Caserta (Italy)
Drs. Carla Ferreri and Chris Chatgilialoglu
ISOF, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy
Dr. Marina Marini
Department of Histology, Embryology, and Applied Biology, University of Bologna, 40126
Bologna (Italy)
Prof. Arsenio Veicsteinas
Institute of Physical Exercise, Health, and Sports, Faculty of Exercise Science, University
of Milan, Milan (Italy)
Prof. Toshkon G. Goulyamova
Institute of Microbiology, Uzbekistan Academy of Sciences, Tashkent, Uzbekistan
Drs. Agata Gambacorta and Barbara Nicolaus
Institute of Chemistry of Biological Interest Molecules (ICMIB, CNR), Pozzuoli, Napoli
(Italy)
Publications (last 5 years)
1 –De Maio A., El- Mansry M., Di Martino S., Rossi S., Bencivenga U., Grano V, Diano N.,
Canciglia P. and Mita D. G.. A novel packed bioreactor operating under isohermal and non
isothermal conditions. Biotechnology and Bioengineering, 86, 308-316, (2004).
2 - Grano V., Tasco R., Casadio R., Diano N., Portaccio M., Rossi S., Bencivnga U., Compiani
M., De Maio A. and Mita D.G.. Reduction of active elastase concentration by means of
immobilized inhibithors: a novel therapeutic approach . Biotechnology Progress, 20, 968-974,
(2004).
3 - M.R. Faraone Mennella, A. De Maio, A. Gambacorta, B. Nicolaus e B. Farina. The
(ADPribosyl)ation system in the archaeon Sulfolobus solfataricus. Biochemistry and Molecular
Biology in the Thermophilic Archaeon Sulfolobus solfataricus. Transworld Research NetworkEditors: Benedetta Farina e M. R. Faraone Mennella, pag 151-169 (2004).
4 - C.Ferreri, I. Manco, M.R. Faraone-Mennella, A. Torreggiani, M. Tamba, C. Chatgilialoglu, A
biomimetic model of tandem radical damage involving sulfur-containing proteins and unsaturated
lipids. Chem. Biochem. 5(12), 1710-1712 (2004)
5 - M. R. Faraone-Mennella, A. De Maio, A. Petrella E. Syntichaki, A.M. Kerbalaeva, S.M.
Nasmetova, T.G. Goulyamova, and B. Farina. YEAST (ADPRIBOSYL)ATION: REVISITING A
CONTROVERSIAL QUESTION. J. Cell. Biochem. 94(6):1258-1266. (2005).
6 - M.R. Faraone-Mennella, Chromatin architecture and functions: the role(s) of poly(ADPRIBOSE) polymerase and poly(ADPribosyl)ation of nuclear proteins.Biochem Cell Biol.
83(3):396-404 (2005).
7 - A. Torreggiani, M. Tamba, I. Manco, M. R. Faraone-Mennella, C. Ferreri, C. Chatgilialoglu
Radiation Damage of Lysozyme in a biomimetic model: some insights by Raman spectroscopy.
J.Mol.Structure 744-747 (2005) 767-773
8 - M. Portaccio , S. Di Martino , P. Maiuri , D. Durante , P. De Luca , M. Lepore ,U.
Bencivenga , S. Rossi , A. De Maio, D.G. Mita. Biosensors for phenolic compounds: The
catechol as a substrate model. Journal of Molecular Catalysis B: Enzymatic 41, 97–102,
(2006)
9 - A. Torreggiani, M. Tamba, I. Manco, M. R. Faraone-Mennella, C. Ferreri, C. Chatgilialoglu
Investigation of radical-based damage of RNase A in aqueous solution and lipid vesicles.
Biopolymers. 81, 39-50 (2006)
10 - M.R. Faraone-Mennella , A. De Maio, A. Petrella , M. Romano , P. Favaloro, A. Gambacorta,
L. Lama, B. Nicolaus, B. Farina. The (ADP-ribosyl)ation reaction in thermophilic bacteria.Res
Microbiol. 157:531-537, 2006
11 - Ferreri, I. Manco, M.R. Faraone-Mennella, A. Torreggiani, M.Tamba, S. Manara,
C.Chatgilialoglu , The reaction of hydrogen atoms with methionine residues: A model of reductive
radical stress causing tandem protein-lipid damage. Chembiochem. 2006 Nov;7(11):1738-44.
12 - MR Faraone-Mennella MR, A De Maio, A Petrella, M Romano, P Favaloro, A Gambacorta
A, L Lama, B Nicolaus, B Farina. The (ADP-ribosyl)ation reaction in thermophilic bacteria.Res
Microbiol. 2006 Jul-Aug;157(6):531-7. Epub 2006 Feb 17.
13 - A. Torreggiani, M. Di Foggia, I. Manco, De Maio A., S.A. Markarian, S. Bonora, (2008), Effect
of sulfoxides on the thermal denaturation of hen lysozyme: A calorimetric and Raman study.
Journal of Molecular Structure, 891, 115-122, (2008)
14 – A Ianaro, M Tersigni, G Belardo, S Di Martino, M Napolitano, G Palmieri, M Sini, A De
Maio, M Ombra, G Gentilcore, M Capone, M Ascierto, RA Satriano, B Farina, MR FaraoneMennella, PA Ascierto, A Ialenti. NEMO-binding domain peptide inhibits proliferation of human
melanoma cells. Cancer Lett. 2009 Feb 18;274(2):331-6. Epub 2008 Nov 11
15 – MR Faraone-Mennella, A Ferone, L Marino, A Cardone, R Comitato, P Venditti, S Di Meo,
B Farina. Poly(ADP-ribosyl)ation of proteins and germ cell development in hyperthyroid rat
testes. Mol Cell Biochem. 2009 Mar;323(1-2):119-29. Epub 2008 Dec 12
16 - A Di Maro, A De Maio, S. Castellano, A Parente, B Farina, MR Faraone-Mennella. The
ADP-ribosylating thermozyme from Sulfolobus solfataricus is a DING protein. Biol Chem. 2009
Jan;390(1):27-30.
17 – S Castellano, B Farina, MR Faraone-Mennella. The ADP-ribosylation of Sulfolobus
solfataricus Sso7 modulates protein/DNA interactions in vitro.FEBS Lett. 2009 Mar 10. [Epub
ahead of print]