Document

Pier Paolo Claudio, M.D., Ph.D.
July 2009
CURRICULUM VITAE
Pier Paolo Claudio
PERSONAL DATA:
Date and Place of Birth:
May 20, 1964; Naples, Italy.
Laboratory Telephone No.:
(304) 696-3576
Office Telephone No.: (304) 696-3516
Laboratory address:
Joan C. Edwards School of Medicine,
Marshall University,
Robert C. Byrd Biotechnology Science Center,
One John Marshall Drive,
Dept. of Biochemistry and Microbiology,
& Department of Surgery,
Suite 336Q,
Huntington, WV 25755
E-mail : [email protected]
Private E-mai: [email protected]
Pier Paolo Claudio, M.D., Ph.D.
EDUCATION:
1983-1989
1989-1994
M.D. Degree, summa cum laude. Medical School,
University of Naples “Federico II”, Naples, Italy.
Residency program and Ph.D. in Maxillo-Facial Sciences. Medical School,
University of Naples “Federico II”, Naples, Italy.
PROFESSIONAL EXPERIENCE:
1985-1989
1989-1994
1992
1993-1994
1994 - 1996
1996-1998
1998-2002
1997-1998
1998- 2004
2004- 2006
2004- 2006
2006- present
2006- present
2008-present
Internship at Dept. of Maxillo-Facial Surgery,
Medical School, University of Naples “Federico II”, Naples, Italy.
Residency program and Ph.D. in Maxillo-Facial Sciences, Medical School,
University of Naples “Federico II”, Naples, Italy.
Research fellow of the Sloan Kettering Cancer Center, Head and
Neck Department, New York, USA.
Research fellow of the Fels Institute for Cancer
Research and Molecular Biology.
Temple University, School of Medicine, Philadelphia,
PA 19140.
Post-doctoral fellow of the Jefferson Cancer Institute,
Thomas Jefferson University, Philadelphia, PA 19107.
Instructor, Dept. of Pathology, Anatomy and Cell Biology, Thomas Jefferson
University, Philadelphia, PA 19107
Assistant Professor, Dept. of Pathology, Anatomy and Cell Biology, Thomas
Jefferson University, Philadelphia, PA 19107
Scientific collaboration contract with the University of Naples
“Federico II,” Italy.
Assistant Professor, Dept. of Odontostomatologic and Maxillofacial Sciences,
Medical School, University of Naples “Federico II”, Naples, Italy.
Associate Professor, Dept. of Biology, Center for Biotechnology,
Temple University, Philadelphia, PA 19122.
Director of Molecular Therapeutics Program,
Center for Biotechnology,
Temple University, Philadelphia, PA 19122.
Associate Professor, Dept. of Biochemistry and Microbiology,
Joan C. Edwards School of Medicine,
Marshall University, Huntington, WV 25705.
Associate Professor, Dept. of Surgery,
Joan C. Edwards School of Medicine,
Marshall University, Huntington, WV 25705.
President and Founder, Phoenix Biotherapeutics, LLC
AWARDS:
1987
1989
1994
1999
2002
2003
II Edition of the national award for young researchers
“A. Schweitzer”, Italy.
M.D. Degree, Summa cum laude.
Residency program in Maxillo-Facial Surgery, Summa cum laude.
Lions Club Napoli-Mergellina for outstanding achievements in cancer research.
Who’s Who in Science and Engineering, 2002 edition.
Who’s Who in Science and Engineering, 2003 edition
Pier Paolo Claudio, M.D., Ph.D.
2003
2004
2004
2004
2007
2008
2000 Outstanding Scientists of the 21st Century.
Who’s Who in Science and Engineering, 2004 edition
Research Board of Advisors, Who’s is Who.
Rotary Club – Napoli for outstanding achievements in gene therapy
International Award “Sebetia-Ter” for Biomedical Sciences
Lion’s Club Fondi for Stem Cell Research
FELLOWSHIPS:
1989-1994
1994-1995
1995-1997
1999-2001
Fellowship awarded for training in Maxillo-Facial Surgery at the
Department of Maxillo-Facial Surgery, University of Naples
“Federico II,” Italy.
Fellowship from “Lega Nazionale Lotta contro i Tumori” of the
National Institute of Tumor “Fondazione Senatore Pascale,”
Naples, Italy.
Fellowship from the American-Italian Cancer Foundation, New York, USA.
Fellowship from the “Associazione Leonardo di Capua”, Napoli, Italy,
for a research project on Nasopharyngeal Cancer.
GRANTS:
Past
WW Smith Charity Foundation. # C0305
Pier Paolo Claudio (PI): Ultrasound enhancement of viral-mediated gene transfer following systemic
administration. $ 120,000 (Expired Nov, 2006)
NIH R01 CA60999: Rb2/p130 from the mechanism to gene therapy.
Pier Paolo Claudio (CoPI) $ 1,250,000
NIH P01 NS36466-08: Project #2 Tumor suppressor Rb family/pRb2 in medulloblastoma.
Pier Paolo Claudio (CoPI) $ 750,000 Project#2
CDDC grant: Microgravity sensitization to chemotherapy of multi-drug resistant cancer cells
Pier Paolo Claudio (PI) $ 20,000/year
Current
NIH R21 CA131395 Ultrasound guided site-specific gene delivery in prostate cancer
Pier Paolo Claudio (PI) $ 385,000
NIH R03: Image guided enhancement of mda-7 gene therapy in pancreas adenocarcinoma
Pier Paolo Claudio (PI) $100,000
Pending:
NIH R15: Cdk9 and p53 interplay in oral cancer
Pier Paolo Claudio (PI) $ 150,000
NIH R01: Image guided enhancement of mda-7 gene therapy
Pier Paolo Claudio (PI) $1,250,000
Pier Paolo Claudio, M.D., Ph.D.
MENTORING EXPERIENCE
 Primary mentor for Alessandra Zamparelli, Master student at Jefferson University (1998-2002).
 Primary mentor for Chiara Mariano, Ph.D. student at Temple University (2002-2005)
 Primary mentor for Tiziana Tonini, Ph.D. student at Temple University (2002-2005)
 Primary mentor for Giovanni Abbadessa, Ph.D. student at Temple University (2002-2005)
 Secondary mentor for Steven Tutton, Ph.D. student at Temple University (2002-2006)
 Secondary mentor for Giuseppe Russo, Ph.D. student at Temple University (2002-2006).
 Primary mentor for Viviana Vogiatzi, Ph.D. student at Temple University (2002-2006).
 Primary mentor for Sarah Elizabeth Daron Kelly, a Master student in my laboratory at Marshall
University (2006-2009)
 Secondary mentor for Joseph Adam Hall, Ph.D. student in Dr. Philippe Georgel’s laboratory at
Marshall University (2007-present).
 Primary mentor for Ms. Miranda Carper, Ph.D. student in my laboratory at Marshall University
(2007-present).
 Primary mentor for Mr. Rounak Nande, Master student in my laboratory at Marshall University
(2008-present)
 Primary mentor for Sarah Elizabeth Daron Kelly, a Ph.D. student in my laboratory at Marshall
University (2009- )

UNIVERSITY SERVICES:
2006-present
Member of Marshall University Library Committee
2007-present
Member of the Marshall University Institutional Biosafety Committee (IBC)
2008-present
Member of the Marshall University Faculty Senate
ORGANIZATION AFFILIATIONS:
Since 1990
Since 1990
Since 1991
Since 2000
Since 2008
Since 2009
Since 2009
Societa’ italiana dei Giovani Chirurghi (S.P.I.G.C.)
Societa' Italiana di Chirurgia Maxillo Facciale (S.I.C.M.F.)
European Association for Cranio-Maxillo-Facial Surgery (E.A.C.M.F.)
American Association for Cancer Reserach (AACR)
President and Founder of the Green Hope Foundation for Cancer
Research and Molecular Medicine.
American Society for Gene & Cell Therapy. (ASGCT)
Head & Neck Optical Diagnostics Society (HNODS)
GRANTS EVALUATOR BOARD:
1999 – 2003
2000-present
2004-present
2008-present
Expert-Evaluator of the European Commission for the V Framework
Program (Science, Research and Development)
Grant evaluator for the Department of Veteran Affairs. Livermore, CA.
Ad Hoc Grant evaluator NIH, Bethesda, MD
Grant evaluator EVAL-INCO (Evaluators Database for International Cooperation)
Pier Paolo Claudio, M.D., Ph.D.
JOURNAL REVIEWER:
From 1997
From 1999
From 1999
From 1999
From 2000
From 2000
From 2000
From 2000
From 2000
From 2000
From 2001
From 2002
From 2003
From 2004
From 2005
From 2005
From 2006
From 2007
From 2008
Cancer Research
Journal of Viral Immunology
Journal of Neuroimmunology
Journal of Virology
Human Pathology
Life Sciences
Clinical Cancer Research
J Cell Physiology
J Biol Chemistry
Oncogene
Int. J. of Cancer
American Journal of Cardiovascular Research
PNAS
Journal of Experimental & Clinical Cancer Research
Journal of Urology
Digestive Disease and Sciences
Neoplasia
Molecular Therapy
Brain Research
JOURNAL EDITOR:
20012004200520052005200520062008
The women’s oncology review (Assistant and contributing Editor)
Regional Editor of the Journal of Experimental & Clinical Cancer Research (Editor-USA)
International Journal of Biomedical Science (Molecular Biology Section)
Drugs News and Perspectives (Editor-USA)
Drugs of Today (Editor USA)
Drugs of the Future (Editor USA).
Journal Experimental & Clinical Cancer Research (Editor-USA)
Current Signal Transduction Therapy (Editor-USA)
Pier Paolo Claudio, M.D., Ph.D.
PATENTS:
Awarded:
1. US Patent Application Number 6596698. Methods of inhibiting smooth muscle cell
proliferation and preventing restenosis with a vector expressing RB2/p130. Issued on
July 22, 2003.
2. U.S. Patent Application Serial Number 10/250,805 “Method for quantification of
recombinant viruses” issued on February 12, 2004.
Pending:
1. European Patent Application. Methods of inhibiting smooth muscle cell proliferation
and preventing restenosis with a vector expressing RB2/p130.
2. European Patent Application “Method for quantification of recombinant viruses”
3. Japanese Patent Application. Methods of inhibiting smooth muscle cell proliferation
and preventing restenosis with a vector expressing RB2/p130.
4. Japanese Patent Application “Method for quantification of recombinant viruses”
5. U.S. Provisional Patent Application “Osteointegrated implant system”
6. Italian Patent Application: “Osteointegrated implant”
7. U.S. Patent Application “Method and composition for the site-selective gene delivery using viruses”
8. U.S. Provisional Patent Application “Stem Cell and Associated Factor Production Method”
9. U.S. Provisional Patent Application “Methods for stem cells production and therapy”
10. U.S. Provisional patent Applicartion “Methods and composition for site-selective Mda-7/IL24 gene
delivery”
Pier Paolo Claudio, M.D., Ph.D.
TALKS:
1. Claudio P.P. (1992): L’impiego del Laser C02 nella chirurgia del cavo orale.
2. (Surgical use of the CO2 Laser in the oral cavity) IV giornate mediterranee di odontoiatria.
Napoli
3. Claudio P.P.(1992): I reinterventi nel cancro differenziato della tiroide.
4. (Interventions for recurrence on differentiated cancers of the thyroid) V Cong. Naz. S.P.I.G.C.
Ischia, May 21-23.
5. Pier Paolo Claudio (1999): Rb2/p130 in the cell cycle and tumorigenesis. Relazione alla
sessione “Cell Cycle and Growth Control” del Meeting annuale della German Society for Cell
Biology (DGZ), Rostock, Germany, March 14-18.
6. Claudio P.P. (1999): Anno 2000. I geni: bersagli nella diagnosi e nella terapia del cancro. (Year
2000. Genes: targets in the diagnosis and therapy of cancer). Presidio Ospedaliero Dono Svizzero,
Premio Lions Club, Napoli Mergellina, distretto 108YA. Formia, Italy, October 20.
7. Claudio P.P. (2000): Ruolo dei geni oncosoppressori nella terapia delle neoplasie. Prospettive nel
carcinoma della prostata. (Role of oncosuppressor genes in neoplasias therapy. Perpectives in
prostate cancer). Istituto nazionale per lo Studio e la Cura dei Tumori, Fondazione Senatore
Pascale, Napoli, Italy, May 9.
8. Claudio P.P. (2000): Mutations in the Retinoblastoma-related gene RB2/p130 in primary
nasopharyngeal carcinoma. International Conference on Basic and Clinical Aspects of Cell Cycle
Control, Siena, Italy, May 31.
9. Claudio P. P. (2000): Mutations in the Retinoblastoma-related gene RB2/p130 in primary
nasopharyngeal carcinoma. Napoli, 24-27 Settembre.
10. Claudio P. P. (2000): Oncosuppressor genes as molecular target for neoplasias gene therapy. First
international Congress on new molecular target for neoplasias therapy. Buenos Aires, October 78.
11. Claudio P. P. (2001): Ruolo della terapia genica nella cura dei tumori del polmone. Forum
nazionale di Oncologia (SIT), Foggia, 29-31 marzo.
12. Claudio P. P. (2001): Ruolo della biologia molecolare nella cura dei carcinomi del pancreas.
Bari, 6-7 aprile.
13. Claudio P.P. (2001): Malignant Mesothelioma – Therapeutic Options and Role of SV40: An
Update. April 20 – 21, Chicago, (IL).
14. Claudio P.P. (2001): New prognostic and therapeutic molecular features in head and neck cancer.
XII SICMF Congress, 6-8 June, Naples, Italy.
15. Claudio P.P. (2001): pRb2/p130 and p107 associate with the nuclear matrix and E2F4
transcription factor in a cell cycle-specific manner. Aug 16, Saint Paul (VT).Claudio P.P. (2001):
Molecular genetics in the pathogenesis, prognosis and therapy of gynecological malignancies. 3rd
Joint International Workshop “Histologic and Cytologic Characterization of Human Tumors:
Adjuncts in the Diagnosis, Prognosis and Clinical Monitoring”, October 10-13, Ischia, Italy.
16. Claudio P.P. (2002): Ruolo della biologia molecolare nei carcinomi del colon. Forum nazionale
di Oncologia (SIT), Foggia, 14-16 April.
17. Claudio PP. (2002): RB2/p130 gene enhanced expression down-regulates Vascular Epithelial
Pier Paolo Claudio, M.D., Ph.D.
Growth Factor expression and inhibits Angiogenesis in vivo. European Respiratory Society (ERS)
Annual Congress, Stockholm, 13-18 September.
18. Claudio P.P. (2003): Gene transfer delivery systems: current approaches and future perspectives.
4th Joint International Workshop “Histologic and cytologic characterization of human tumors:
new basic discoveries and frontiers in diagnosis, prognosis and prediction of response to therapy
in human thyroid, urinary bladder and prostate tumors. Ischia, Italy, April 30-May 3.
19. Claudio P.P. Rapid Selection and Proliferation of Cancer Stem Cells in a Nasa Developed
Microgravity Bioreactor: Therapeutic Implications. May 27, 2008. Invited Talk to the Ceinge
Institute for Biotechnology, Naples, Italy.
20. Claudio P.P. Ultrasound Mda7/IL-24 Viral-Mediated Gene Transfer In Vitro and In Vivo.
University of Naples, “Federico II”, School of Medicine, May 29, 2008.
21. Claudio P.P. Rapid Selection and Proliferation of Cancer Stem Cells in a Nasa Developed
Microgravity Bioreactor: Therapeutic Implications. May 22, 2008. Invited Talk from the Lion’s
Club, Fondi Hospital, Fondi, Italy.
22. Claudio P.P. Ultrasound Mda7/IL-24 Viral-Mediated Gene Transfer In Vitro and In Vivo.
Marshall University, Johan C Edwards School of Medicine, Cancer Grand Rounds, June, 2008.
Pier Paolo Claudio, M.D., Ph.D.
PAPERS AND COMMUNICATIONS AT CONGRESSES:
1. F. Claudio, F. Cacace, F. Scognamiglio, M. Pizzorusso, A. Amato, P.P. Claudio, F. Ionna, D. Paladino.
(1984): Cavo orale: proposta di una nuova classificazione clinica.(Tumors of the oral cavity: proposal for
a new clinical classification) Atti VIII Cong. Naz. S.I.C.O. Bologna, Pag. 1315 - 1317.
2. A. Iazzetta, P.P. Claudio, A. De Martino, A. Guarino, F. Ionna, O. Schiappa. (1984): La nutrizione
enterale totale in chirurgia maxillo Faciale.(Total parenteral nutrition in Maxillo-Facial surgery) Atti VIII
Cong. Naz. S.I.C.O. Bologna, Pag. 687 - 691. 3. F. Claudio, M. Pizzorusso, F. Ionna, P.P. Claudio, F.
Cacace. (1985): I tumori avanzati differenziati della tiroide: esperienza dell'Istituto dei tumori di Napoli.
(Advanced tumors of the thyroid: experience of the Cancer Institute of Naples) Atti Cong. Sez. ital.
International College of Surgeons. Napoli, Pag. 223.
4. F. Claudio, F. Scognamiglio, F. Ionna, P.P. Claudio, F. Cacace, G. Savastano, L. Califano, A. Cortese.
(1985): Le infusioni arteriose selettive nei Carcinomi cutanei avanzati del capo. (Selective arterial
infusions in the advanced cutaneous Carcinomas of the head) Atti IV Cong. ital. Chir. Max. Fac. Ancona,
Pag. 889 - 890.
5. C. Giardino, G.S. Sica, A. Cozzolino, G. Savastano, F. Claudio, F. Cacace, G. Campobasso, P.P.
Claudio. (1985): La nostra esperienza nella chirurgia ricostruttiva per i tumori del labbro. (Our
experience in the reconstructive surgery for lips tumors) Atti IV Cong. ital. Chir. Max. Fac. Ancona, Pag.
189 - 199.
6. F. Claudio, A. Amato, D. Paladino, P.P. Claudio, F. Ionna, C. Giardino, R. De Santis, M. Poltronieri.
(1985): Gli interventi allargati per tumori avanzati della parotide. (Commando intervention for advanced
tumors of the parotid gland) Atti IV Cong. ital. Chir. Max. Fac. Ancona, Pag. 891 - 893.
7. F. Claudio, F. Scognamiglio, P.P. Claudio, D. Paladino, G. Campobasso. (1985): Metastasi linfonodali
nei tumori del cavo orale. (Lymphonodal metastasis in oral cancers) Atti IV Cong. ital. Chir. Max. Fac.
Ancona, Pag. 881 - 883.
8. F. Claudio, F. Scognamiglio, M. Pizzorusso, P.P. Claudio, G. Campobasso, D. Paladino, C. Giardino,
V. Minopoli, G. Vittozzi.(1985): Gli interventi allargati nei tumori avanzati della testa collo. (Commando
intervention for advanced tumors of the head and neck) Atti IV Cong. ital. Chir. Max. Fac. Ancona, Pag.
899 - 901.
9. F. Claudio, A. Amato, D. Paladino, P.P. Claudio, P. Marcolin, F. Ionna, C. Giardino, L. Califano.
(1985): La linfadenectomia nei casi N2 - N3 per tumori del cavo orale. (Lymphoadenectomy in oral
cancers with N2-N3) Atti IV Cong. ital. Chir. Max. Fac. Ancona, Pag. 495 - 497.
10. F. Claudio, F. Scognamiglio, A. Amato, D. Paladino, P.P. Claudio, G. Vela. (1985): I tumori avanzati
del cavo orale: gli interventi allargati. Esperienza dell'Istituto dei tumori di Napoli.(Advanced tumors of
the oral cavity: commando intervention. Experience of the Cancer Institute of Naples) Atti IX Cong. Naz.
S.I.C.O. S. Margherita di Pula, Pag. 881 – 884.
11. F. Claudio, M. Pizzorusso, P.P. Claudio, F. Scognamiglio, , G. Campobasso. (1985): Ruolo della
terapia infusionale selettiva nei Carcinomi cutanei avanzati del capo: esperienza dell'Istituto dei tumori di
Napoli.(Role of the selective infusional therapy in advanced cutaneous carcinoma of the head. Experience
of the Cancer Institute of Naples) Atti IX Cong. Naz. S.I.C.O. S. Margherita di Pula, Pag. 873 - 876.
12. F. Claudio, F. Scognamiglio, P.P. Claudio, F. Ionna, G. Campobasso, F. Baldassarre. (1985): Il
Carcinoma cutaneo nei giovani: esperienza dell'Istituto dei tumori di Napoli. (Cutaneous carcinoma in
childhood. Experience of the Cancer Institute of Naples) Atti IX Cong. Naz. S.I.C.O. S. Margherita di
Pula, Pag. 515 - 519.
13. F. Claudio, F. Ionna, D. Paladino, P.P. Claudio, L. Caramazza, C. Giardino, G. Savastano, G.
Lavorgna. (1985): Ruolo della chirurgia nella programmazione terapeutica dei tumori maligni avanzati
del cavo orale. (Role of surgery in advanced malignant tumors of the oral cavity) Atti XX Cong.
S.I.O.C.M.F. S. Vincent, Pag. 211- 214.
Pier Paolo Claudio, M.D., Ph.D.
14. F. Claudio, D. Paladino, P.P. Claudio, G. Campobasso, F. Ionna, C. Giardino, G.S. Sica, A.
Cozzolino.(1985): Le dissezioni linfonodali nei tumori maligni del cavo orale. (Lymphonodal dissection
in malignant tumors of the oral cavity) Atti XX Cong. S.I.O.C.M.F. S. Vincent, Pag. 205 - 209.
15. F. Claudio, C. Giardino, F. Ionna, P.P. Claudio, R. De Santis. (1986): Parotid advanced tumors. Atti
VIII Cong. Europ. E.A.C.M.F.S. Madrid, Pag. 5.
16. F. Claudio, A. Amato, F. Cacace, F. Ionna, P.P. Claudio e M. Pizzorusso. (1987): Nuova strategia
interdisciplinare in rapporto a problemi exeretico ricostruttivi per tumori avanzati del capo e del collo.
(New interdisciplinary strategy regarding ablationreconstructive problems for advanced tumors of the
head and neck) Atti XI Cong Naz. S.I.C.O. Genova, Pag. 675 - 678.
17. F. Claudio, F. Cacace, F. Ionna e P.P. Claudio. (1988): La chemioterapia infusionale selettiva nei
carcinomi avanzati del capo. (Selective infusional chemotherapy in advanced carcinomas of the head)
Atti XII Cong. Naz. S.I.C.O. Isola Capo Rizzuto, Pag.121 - 128.
18. F. Claudio, F. Cacace e P.P. Claudio. (1989): Linfadenectomie di principio? (Lymphoadenectomy: is
it mandatory?) Atti XIII Cong. S.I.C.O. Roma, Pag. 71 - 80.
19. L. Califano, A. Cortese e P.P. Claudio. (1989): L'alimentazione artificiale in chirurgia maxillo
facciale. (Artificial nutrition in maxillo-facial surgery) Atti Tavola Rotonda S.P.I.G.C., 91° Cong. S.I.C.O.
Genova, Pag. 69 - 73.
20. F. Claudio, A. Amato e P.P. Claudio. (1990): Gli interventi allargati nei tumori avanzati della
parotide. (Commando intervention in advanced tumors of the parotid gland), Atti X Cong. S.I.E.C., S.
Margherita di Pula, Pag. 245 - 250.
21. P.P. Claudio, A. Amato, G. Savastano e G. Della Pietra. (1991): Le ricostruzioni con lembi cutanei e
miocutanei dopo interventi demolitivi della testa-collo. (Reconstructions with cutaneous and
musculocutaneous flaps after demolitive interventions on the head and neck) Atti VII Cong. S.I.C.M.F.
Ischia, Pag. 1325 - 1329.
22. P.P. Claudio, A. Amato, G. Savastano e G. Della Pietra. (1991): Ruolo della terapia chirurgica nei
tumori maligni avanzati della parotide. (Role of surgical therapy in malignant advanced tumors of the
parotid gland) Atti VII Cong. S.I.C.M.F. Ischia, Pag. 345 - 348.
23. F. Claudio, A. Amato e P.P. Claudio. (1991): Parotidectomie: esperienza dell'Istituto dei Tumori di
Napoli dal 1960 al 1988. (Parotidectomy: experience of the Cancer Institute of Naples from 1960 to
1988), Atti VII Cong. S.I.C.M.F. Ischia, Pag. 213 - 220.
24. A. Amato, P.P. Claudio, G. Savastano e G. Della Pietra. (1991): La dissezione linfonodale nei tumori
maligni avanzati della parotide. (Lymphonodal dissection in malignant advanced tumors of the parotid
gland), Atti VII Cong. S.I.C.M.F. Ischia, Pag. 341 - 343.
25. C. Giardino, P.P. Claudio, A. Amato e G. Savastano. (1991): Scialectomia totale versus subtotale
nell'adenoma pleomorfo della parotide. (Total scialectomy versus subtotal in the pleomorphic adenoma of
the parotid gland), Atti VII Cong. S.I.C.M.F. Ischia, Pag. 335 - 339.
26. C. Giardino, P.P. Claudio, A. Amato e G. Savastano. (1991): Tumori del cavo orale. Disseminazione
linfatica: prevenzione chirurgica. (Tumors of the oral cavity. Lymphatic spread: surgical prevention), Atti
VII Cong. S.I.C.M.F. Ischia, Pag. 1161 - 1165.
27. G. Savastano, A. Russo, P.P. Claudio, G. Della Pietra, S. Siciliano. (1991): Considerazioni clinicoterapeutiche sui Carcinomi adenoideo-cistici delle ghiandole
salivari maggiori. (Clinical-therapeutic considerations on adenoid-cystic carcinomas of the major salivary
glands), Atti VII Cong. S.I.C.M.F. Ischia, Pag. 329 - 333
28. Claudio P.P., Papa F., Cangiano G. (1992): L’impiego del Laser C02 nella chirurgia del cavo orale.
(Surgical use of the CO2 Laser in the oral cavity) Atti delle IV giornate mediterranee di odontoiatria.
Napoli.
Pier Paolo Claudio, M.D., Ph.D.
29. Claudio P.P., Amato A.(1992): I reinterventi nel cancro differenziato della tiroide. (Interventions for
recurrence on differentiated cancers of the thyroid) Relazione al V Cong. Naz. S.P.I.G.C. Ischia 21 - 23
May, Pag. 558 - 565.
30. De Luca A., Claudio P.P., Peschle C., Giordano A., Condorelli G. (1994): Interaction between cellcycle regulatory genes and transcription factors during skeletal muscle cell differentiation. 4th
International Symposium on Endocrinology Under 35. Rome, Italy, 25-27 May. Advances in
Endocrinology: Cell Cycle and Cancer. Ares Serono Symposia Publications (Raven Press) Pag. 37.
31. Mayol X., Baldi A., Sang N., Fu Y., De Luca A., Claudio P.P., Grana X., and Giordano A. (1994):
The Adenovirus E1A oncoprotein: a link between transformation and cell cycle. 4th International
Symposium on Endocrinology Under 35. Rome, Italy, 25-27 May. Advances in Endocrinology: Cell
Cycle and Cancer. Ares Serono Symposia Publications (Raven Press) Pag. 40.
32. Giordano A., Baldi A., Claudio P.P., De Luca A., Mensorio C. (1994): Adenovirus E1A targets key
regulators of cell proliferation. IIL Congresso Nazionale della Societa’ italiana di Anatomia. Roma, 2-5
October.
33. De Luca A., Claudio P.P., De Luca B., Giordano A., Condorelli G.(1994): Muscle specific
transcription factors interact with cell-cycle regulatory genes during skeletal muscle cell differentiation.
IIL Congresso Nazionale della Societa’ italiana di Anatomia. Roma, 2 -5 October.
34. Claudio P.P., Howard C.M., Baldi A., De Luca A., Sang N., MacLachlan T., Yuan W., Fu Y.,
Condorelli G. and Giordano A. (1995): p130/RB2 has similar yet distinctive growth suppressive
properties as retinoblastoma family members, pRb and p107. 86th Annual Meeting of the “American
Association for Cancer Research”, March 18-22. Toronto, Ontario, Canada.
35. Claudio P.P., Howard C.M., Baldi A., De Luca A., Pertile P., Condorelli G., Giordano A. (1995):
Growth suppressive properties of p130/pRb2 and its subcellular localization. XXVI Congresso nazionale
della Societa’ italiana di Istochimica. 8-11 June, Napoli.
36. Baldi A., Claudio P.P., De Luca A., Giordano A. (1995): Genomic structure and
immunohistochemical pattern of the human Rb2/p130 gene in tumors. XXVI Congresso nazionale della
Societa’ italiana di Istochimica. 8-11 June, Napoli.
37. De Luca A., Shu L., MacLachlan T., Sang N, Claudio PP., Baldi A., Giordano A. (1995): Pitalre and
Pisslre, two novel cdc-2 related kinases. XXVI Congresso nazionale della Societa’ italiana di Istochimica.
8-11 June, Napoli.
38. Sang N., Condorelli G., Maclachlan T., Claudio P.P., De Luca A., Yuan W., Fu Y., and Giordano A.
(1995): A novel transactivation activity of adenoviral E1A oncoproteins and its involvement in regulation
of host genes. The 6th SCBA (Society of Chinese Bioscientists in America) International Symposium. 2429 June, Vancouver. Canada.
39. Claudio P.P., Baldi A., Howard C.M., MacLachalan T., and Giordano A. (1995): The pRb2/p130
protein exhibits growth suppressive properties in a cell cycle dependent manner. The Imperial Cancer
Research Fund, Tumour Virus Meeting on Papovaviruses, Papillomavirus and Adenoviruses. 17-22 July,
1995. Churchill College, Cambridge, England.
40. Baldi A., Boccia V., Esposito V., De Luca A., Claudio P.P., MacLachlan T., Giordano A. (1996):
Genomic structure and immunohistochemical pattern of the human retinoblastoma-related RB2/p130
gene in normal tissues. “Cancer and the cell cycle”. Lausanne, January 17-20.
41. Shu L., MacLachlan T.K., Baldi A., De Luca A., Claudio P.P., Condorelli G., Giordano A. (1996):
The PITALRE and PISSLRE cdc2-related kinases are involved in regulation of the cell cycle. “Cancer
and the Cell Cycle”. Lausanne, January 17-20.
42. Claudio P.P., Baldi A., Bonetto F., Howard C.M., Raschella’ G., Giordano A., Paggi M.G. (1996):
The Rb2/p130 protein and cell cycle regulation. “Cancer and the Cell Cycle”. Lausanne, January 17-20.
Pier Paolo Claudio, M.D., Ph.D.
43. Pier Paolo Claudio and Antonio Giordano (1999): Rb2/p130 in the cell cycle and
tumorigenesis. Relazione alla sessione “Cell Cycle and Growth Control” del Meeting annuale della
German Society for Cell Biology (DGZ), Rostock, March 14-18.
44. Pier Paolo Claudio, Candace M. Howard, Giulia De Falco, Luigi Fratta, Giorgio Stassi, Shin-ichiro
Numata, Carmen Pacilio, Alan Davis, James M. Wilson, Massimo Volpe, Bruno Trimarco, Antonio
Giordano e Gianluigi Condorelli (1999): Adenoviral RB2/p130 gene transfer inhibits smooth muscle cell
proliferation and prevents restenosis following angioplasty. Philadelphia, 90th Annual Meeting A.A.C.R.,
April 10-14.
45. Giulia De Falco, Luigi Bagella, Pier Paolo Claudio, Bruna Pucci, Arturo Sala and Antonio Giordano
(1999): Interaction between CDK9 and B-Myb down-regulates BMyb transactivating activity. .
Philadelphia, 90th Annual Meeting A.A.C.R., April 10-14.
46. .Pier Paolo Claudio, Candace M. Howard, Giulia De Falco, Carmen Pacilio, Caterina Cinti, Gaetano
Romano, Corrado Minimo, Nadir M. Maraldi, John D. Minna, Larry Gelbert, Giovan Giacomo Giordano
and Antonio Giordano (1999): Mutations in the Retinoblastoma-related gene RB2/p130 in primary lung
tumors and suppression of tumor growth in vivo by retroviral-mediated gene transfer. Philadelphia, 90th
Annual Meeting A.A.C.R., April 10-14.
47. Claudio P.P., Howard C., Califano L., Cinti C., Giordano A., Giardino C. Mutazioni nel gene
RB2/p130, della famiglia del gene Retinoblastoma, in carcinomi primari del nasofaringe. Atti VI Giornate
Scientifiche delle Facolta’ di Medicina e Chirurgia, Farmacia, Medicina Veterinaria e Agraria. 17/19
Maggio 2000, Napoli
48. Claudio P.P., Zupi A., Bellan C., Zamparelli A., Giordano A., Giardino C. Analisi
immunoistochimica di pRb2/p130, p107, E2F4 e pCNA nei tumori delle ghiandole salivari. Evidenza di
un loro ruolo diagnostico e prognostico. Atti VI Giornate Scientifiche delle Facolta’ di Medicina e
Chirurgia, Farmacia, Medicina Veterinaria e Agraria. 17/19 Maggio 2000, Napoli
49. Jorio F.P., Galderisi U., Piegari E., Di Bernardo G., Cipollaro M., Cascino A., Claudio P.P., Giordano
A., Melone M.A.B. Specific role of pRb2/p130 gene in neurogenesis: its overexpression induces
astrocytes but not neuronal differentiation. Abstracts of the International Conference on Basic and
Clinical Aspects of Cell Cycle Control, May 29- 31, 2000; Siena, Italy.
50. La Sala D., Zamparelli A., Claudio P.P., Maltarello M.C., Trimarchi C., Ognibene A., Giordano A.,
Cinti C. Characterization of molecular mechanisms in a new multidrugresistant human osteosarcoma cell
line (HOS DXR150). Abstracts of the International Conference on Basic and Clinical Aspects of Cell
Cycle Control, May 29-31, 2000; Siena, Italy.
51. Cinti C., Claudio P.P., De Luca A., Cuccurese M., D’Esposito M., La Sala D., Halazonetis T.D.,
Giordano A., Maraldi M.N. A serine 37 mutation associated with two missense mutations at highly
conserved regions of p53 affect pro-apoptotic genes expression inducing γ-irradiation resistance.
Abstracts of the International Conference on Basic and Clinical Aspects of Cell Cycle Control, May 2931, 2000; Siena, Italy.
52. Trimarchi C., Claudio P.P., Zini N., Stiegler P., Marinelli F., La Sala D., Maltarello M.C., Ognibene
A., Giordano A., Cinti C. pRb2/p130 and p107 associate with the nuclear matrix and E2F4 transcription
factor in a cell cycle-specific manner. Abstracts of the International Conference on Basic and Clinical
Aspects of Cell Cycle Control, May 29-31, 2000; Siena, Italy.
53. Claudio P.P., Califano L., Zupi A., Bellan C., Zamparelli A., Cinti C., Leoncini L., Giardino C.,
Giordano A. pRb2/p130 expression in salivary gland tumors. Its prognostic and diagnostic role. Abstracts
of the International Conference on Basic and Clinical Aspects of Cell Cycle Control, May 29-31, 2000;
Siena, Italy.
54. Claudio P.P., Howard C., Califano L., Cinti C., Leoncini L., Giardino C., Giordano A. Mutations in
the Retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. Abstracts of the
Pier Paolo Claudio, M.D., Ph.D.
International Conference on Basic and Clinical Aspects of Cell Cycle Control, May 29-31, 2000; Siena,
Italy.
55. Claudio, P.P., Califano, L., Zupi, A., Bellan, C., Zamparelli, A., Giordano, A., Giardino, C.
pRb2/p130 expression in salivary gland tumors. Its diagnostic and prognostic role. XVth Congress of the
European Association for Cranio-Maxillofacial Surgery, September 5-9, 2000, Edinburgh, Scotland.
56. Claudio, P.P., Howard, C.M., Califano, L., Cinti, C., Giordano, A., Giardino, C. Mutations in the
Retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. XVth Congress of the
European Association for Cranio-Maxillofacial Surgery, September 5-9, 2000, Edinburgh, Scotland.
57. Pier Paolo Claudio, Sujatha Radhakrishnan, Shou Zheng, Marcus Saunders, Chiara Mariano, Kamel
Khalili, Antonio Giordano, Shohreh Amini, Bassel E Sawaya. P53 decreases the phoshorylation of
polimerase II by cdk9. A novel mechanism for inhibition of HIV-1 gene expression. 4th Joint
International Workshop “Histologic and cytologic characterization of human tumors: new basic
discoveries and frontiers in diagnosis, prognosis and prediction of response to therapy in human thyroid,
urinary bladder and prostate tumors. Ischia, Italy, April 30-May 3.
58. Tiziana Tonini, Giuseppe Russo, Candace M. Howard, Francesca Rossi, Arturo Sala, Gaetano
Romano, Antonio Giordano, and Pier Paolo Claudio. B Myb down-regulates the Retinoblastoma family
member pRb2/p130 promoter. 4th Joint International Workshop “Histologic and cytologic
characterization of human tumors: new basic discoveries and frontiers in diagnosis, prognosis and
prediction of response to therapy in human thyroid, urinary bladder and prostate tumors. Ischia, Italy,
April 30-May 3.
59. Candace M. Howard, Flemming Forsberg, Ji-Bin Liu, Daniel A. Merton, Corrado Minimo, Pier
Paolo Claudio. Using a Commercial Ultrasound Contrast Agent for Viral Mediated Gene Transfer In
Vitro and In Vivo. Proceedings 6th International Symposium on Therapeutic Ultrasound. 30th August 2nd September 2006 . Oxford, UK.
60.Pierpaolo Aimola, Candace M. Howard, Pier Paolo Claudio. Ultrasound contrast mediated gene
therapy in prostate cancer. Cancer Therapeutics: The Road Ahead. A Nature Conference. October 8-10,
2007, Palazzo dei Congressi Di Capri, Capri, Italy.
61. S. E. Kelly, Di Benedetto A., Valluri, J.V., Claudio, P.P. Rapid selection and proliferation of cancer
stem cells Published in Life in Space for Life on Earth. 22 - 27 June 2008, Angers – France
Pier Paolo Claudio, M.D., Ph.D.
PUBLICATIONS:
1. Francesco Claudio, Francesco Cacace, Michele Pizzorusso, Ornella Schiappa, Pier Paolo Claudio,
Franco Ionna, Paolo Marcolin, Antonio Amato. (1983): Strategia di trattamento delle aree di drenaggio
linfonodale nei tumori del cavo orale. (Strategy of treatment for lymphonodal drenage areas in tumors of
the oral cavity) Il medico italiano, 27: 225 - 237.
2. Califano, A. Cortese, P.P. Claudio. (1989): L'alimentazione artificiale in chirurgia maxillo facciale.
(Artificial nutrition in maxillo-facial surgery) Boll. Soc. It. Chir. 10, 3: 173 - 177.
3. Claudio, F. Cacace, M. Rotondi, G. Comella, F. Coucourde, P.P. Claudio, A. M. Bevilacqua, S.
Bonassi, S. Toma. (1990): La chemioterapia intra-arteriosa nei tumori avanzati dalla testa e collo
effettuata mediante una tecnica di trasposizione carotidea. (Intra-artherial chemotherapy in advanced
tumors of the head and neck through a carotid surgical transposition technique) Otorinolaringologia 40:
11 - 9.
4. Giardino C., Claudio P.P. (1992): Proposta di una scheda oncologica clinica per i tumori del cavo
orale. (Proposal of a new clinical chart for tumors of the oral cavity) Riv. Ital. di Chir. Max. Fac., (3): 3948.
5. Papa F., Claudio P.P., Letizia N., Maio C., Giardino C. (1992): Su di un caso di cosidetto Fibroma
Ossificante. (Consideration on an interesting case of ossifying fibroma) Riv. Ital. di Chir. Max. Fac., (3):
53 - 58.
6. Claudio F., Rotondi M., Bonassi S., Cacace F., Comella G., Coucourde F., Claudio P.P., Bevilacqua
A.M., Forma F., Toma S. (1992): Factors affetting response and survival in advance head and neck
cancers treated with intrarterial chemotherapy. Regional Cancer Treatment 4: 180 - 187.
7. Claudio F., Rotondi M., Bonassi S., Cacace F., Comella G., Coucourde F., Claudio P.P., Bevilacqua
A.M., Spadini N., Toma S. (1992): I fattori prognostici nei tumori avanzati della testa e collo trattati
mediante chemioterapia intra-arteriosa. (Prognostic factors in advanced tumors of the head and neck
treated with intrarterial chemotherapy) Otorinolaringologia, Vol 42, (5): 273 - 282.
8. Graña X., De Luca A., Sang N., Fu Y., Claudio P.P., Rossenblatt J., Morgan D.O. and Giordano A.
(1994): PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein
in vitro. Proc. Natl. Acad. Sci. USA. Vol 91, 3834-3838.
9. Graña X., Claudio P.P., De Luca A. , Sang,N., and Giordano, A. (1994): PISSLRE, a human novel
CDC2-related protein kinase. Oncogene 9, 2097-2103.
10. Claudio P.P., Howard C.M., Baldi A., De Luca A., Condorelli G., Sun Y., Colburn N., Calabretta B.,
Giordano A. (1994): p130/PRb2 has similar yet distinctive growth suppressive properties as
retinoblastoma family members, pRb and p107. Cancer Research 54: 5556-5560.
11. Wen S.-C., Ku D.-H., De Luca A., Claudio P.P., Giordano A., and Calabretta B. (1995): ets-2
regulates cdc2 kinase activity in mammalian cells: coordinated expression of cdc2 and cyclin A. Exp.
Cell Res. 217, (1): 8-14.
12. Li S., MacLachlan T., De Luca A., Claudio P.P., Condorelli G.L., and Giordano A. (1995): The cdc2related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer
Research 55, 3992-3995.
13. De Luca A., Baldi A., Claudio P.P., Howard C.M., Campisi S., Giordano A., Condorelli G. (1995):
The retinoblastoma gene and its role in cancer and differentiation. In Future Trends in Endocrinology.
Ares-Serono Symposia Series- Frontiers in Endocrinology 14: 197-206.
14. Baldi A., De Luca A., Claudio P.P., Baldi F., Giordano G.C., Tommasino M., Paggi M.G. and
Giordano A. (1995): The Rb2/p130 gene product is a nuclear protein whose phosphorylation is cell cycle
regulated. Journal of Cellular Biochemistry 59: 402-408.
15. Claudio P.P., De Luca A., Howard C.M., Baldi A., Firpo E.J., Koff A., Paggi M.G., Giordano A.
Pier Paolo Claudio, M.D., Ph.D.
(1996): Functional analysis of pRb2/p130 interaction with cyclins. Cancer Research 56: 2003-2008.
16. Baldi A., Boccia V., Claudio P.P., De Luca A., Giordano A.(1996): Genomic structure of the human
retinoblastoma-related Rb2/p130 gene. Proc. Natl. Acad. Sci. 93: 4629-4632.
17. Esposito V., Baldi A., De Luca A., Paciocco G., Gröger A., Sgaramella G., Claudio P.P., Giordano
G.G., Baldi F., Caputi M., Kaiser H., Giordano A. (1997): Role of PCNA in differentiating between
malignant mesothelioma and mesothelial hyperplasia: prognostic considerations. Anticancer Research 17:
601-604.
18. Esposito V., Baldi A., De Luca A., Claudio P.P., Signoriello G., Bolognese A., Centonze P., Giordano
G.G, Caputi M., Baldi F., Giordano A. (1997): p53 immunostaining in differential diagnosis of pleural
mesothelial proliferations. Anticancer Research 17: 733-736.
19. De Luca A., Esposito V., Baldi A., Claudio P.P, Fu Y., Caputi M., Pisano M.M, Baldi F., Giordano A.
(1997): The cdc2-related kinase PITALRE phosphorylates pRb exclusively on serine and is widely
expressed in human tissues. Journal of Cellular Physiology 172: 265-273.
20. De Luca A., MacLachlan T.K., Bagella L., Dean C., Howard C.M., Claudio P.P., Baldi A., Khalili K.,
Giordano A. (1997): A unique domain of pRb2/p130 acts as an inhibitor of cdk2 kinase activity. J.
Biological Chemisty 272: 20971-20974.
21. Sang N., Claudio P.P, Fu Y., Horikoshi N., Graeven U., Weinmann R., Giordano A. (1997):
Transforming Region of 243 R E1A contains two overlapping but distinct Transactivation Domains. DNA
and Cell Biology. 16:1321-1333.
22. Papa F., Sagliocco R., Cosimo O., Russo A., Claudio P.P., Errico M., Lavorgna G. (1997):
Consideration on a case of carcinoma ex pleomorphic adenoma of the parotid gland. Minerva Stomatol.
46 (11): 615-620.
23. Raschella’, G., Tanno, B., Bonetto, F., Negroni, A., Claudio, P.P., Baldi, A., Amendola, R.,
Calabretta, B., Giordano, A., Paggi, M. (1998): The RB-related gene Rb2/p130 in neuroblastoma
differentiation and in B-myb promoter down-regulation. Cell Death & Diff. 5: 401-407.
24. Leri A., Liu Y., Malhotra A., Li Q., Stiegler P., Claudio P.P., Giordano A., Kajstura J., Hintze H. T.,
Anversa P. (1998): Pacing-induced heart failure in dogs enhances the expression of p53 and p53dependent genes in ventricular myocytes. Circulation. 97:194-203.
25. Leri A., Claudio P.P., Li Q., Wang X., Reiss K., Wang S., Malhotra A., Kajstura J., Anversa P.
(1998): Stretch mediated release of angiotensin II induces myocytes apoptosis by activating p53 that
enhances the local renin-angiotensin system and decrease the Bcl-2-to-Bax protein ratio in the cell. J.
Clin. Invest. 101(7):1326-1342.
26. Ravi K.R., Weber E., McMahon M., Williams R. J., Baylin S., Mai A., Harter L. M., Dillehay L.E.,
Claudio P.P., Giordano A., Nelkin D. B., Mabry M. (1998): Activated Raf-1 causes growth arrest in
human small cell lung cancer cells. J. Clin. Invest. 101:153-159.
27. Romano G., Claudio P.P., Kaiser H.E., Giordano A. (1998): Recent advances, prospects and
problems in designing new strategies for oligonucleotide and gene delivery in therapy. In Vivo 12: 59-68.
28. Tarro G., Esposito C., Perna M., Claudio P.P., Giordano A. (1998): Immunohistochemical
characterization of tumor liberated particles (TLP) expression pattern in lung cancer. Anticancer Res. 18:
2365-2370.
29. Howard C.M., Claudio P.P., Gallia G., Gordon J., Giordano G.G., Khalili K., Giordano A.(1998):
Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo. J.Nat. Cancer Inst.
19: 1451-1460.
30. Mutti L., De Luca A, Claudio P.P., Carbone M., Convertino G., Giordano A. (1998): Simian Virus
40-like DNA sequences and large-T antigen-retinoblastoma family protein pRb2/p130 interaction in
human mesothelioma. Dev. Biol.Stand.: 94:47-53.
Pier Paolo Claudio, M.D., Ph.D.
31. Pacilio C., Florio S., Crispino A., Claudio P.P., Pacilio G., Pagnini G. (1998): Modification of
membrane fluidity and depolarization by some anthracyclines in different cell lines. Anticancer Research.
18(6A):4027-4034.
32. Pupa S.M, Howard C. M., Invernizzi A. M., De Vecchi R., Giani C., Claudio P.P., Colnaghi M. I.,
Giordano A., Ménard S. (1999): Ectopic expression of pRB2/p130 suppresses the tumorigenicity of the
erb-2-overexpressing SKOV3 tumor cell line. Oncogene. 18(3): 651-656.
33. Leri A, Liu Y, Claudio PP, Kajstura J, Wang X, Wang S, Kang P, Malhotra A, Anversa P. Insulin-like
growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin
system and stretch-mediated apoptosis. (1999) Am J Pathol. Feb;154 (2):567-80.
34. Minimo C., Bibbo M., Claudio P.P., De Luca A., Giordano A. (1999): The role of pRb2/p130 protein
in diagnosing lung carcinoma on fine needle aspiration biopsies. Pathol Res and Pract. 195: 67-70.
35. Numata S., Claudio P.P., Giordano A., Croce C.M. (1999): Bdp: a new member of a family of DNA
binding proteins, associates with the retinoblastoma gene product.Cancer Research, 59: 3741-3747.
36. Claudio P.P., Fratta L., Stassi G., Howard C.M., Farina F., Numata S., Pacilio C., Davis A., Lavitrano
M., Volpe, Wilson J.M., Trimarco B., Giordano A., and Condorelli G. (1999): Adenoviral RB2/p130 gene
transfer inhibits smooth muscle cell proliferation and prevents restenosis following angioplasty.
Circulation Research, 85:1032-39.
37. Leoncini L., Bellan C., Claudio P.P., Lazzi S., Cevenini G., Megha T., Laurini L., Luzi P., Fraternali
Orcioni G., Piccioli M., Pileri S., Giardino C., Tosi G.M., Giordano A. (1999): Retinoblastoma related
p107 and pRb2(p130) proteins in malignant lymphomas. Distinct mechanisms of cell growth control.
Clinical Cancer Research, 12: 4065-4072.
38. De Falco G., Bagella L., Claudio P.P., De Luca A., Fu Y., Calabretta B., Sala A., Giordano A. (2000):
Physical interaction between CDK9 and B-Myb results in suppression of B-myb gene autoregulation.
Oncogene , 19: 373-379.
39. Pagnini U., Pacilio C., Florio S., Crispino A., Claudio P.P., Giordano A., Pagnini G. (2000).
Medroxyprogesterone acetate increases anthracyclines uptake in chronic lymphatic leukemia cells: role of
nitric oxide and lipid peroxidation. Anticancer Research, 20 (1A): 33-42.
40. Claudio P.P., Howard C.M., Fu Y., Califano, L., Mercer E.W., Micheli, P., Caputi, M., Giordano A.
(2000): Mutations in the Retinoblastoma-related Gene RB2/p130 in primary nasopharyngeal carcinoma.
Cancer Research, 60: 8-12.
41. Claudio P.P., Howard C.M., Pacilio C., Cinti C., Romano G., Minimo C., Maraldi N.M., Minna J.D.,
Gelbert L., Leoncini, L., Tosi, G.M., Micheli, P., Caputi M., Giordano G.G., and Giordano A. (2000):
Mutations in the Retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth
in vivo by retroviralmediated gene transfer. Cancer Research, 60: 372-382.
42. Cinti C., Claudio P.P., Howard C.M., Neri L.M., Fu Y., Leoncini, Tosi G.M., Maraldi N.M., Giordano
A. (2000) Genetic alterations disrupting the nuclear localization of the retinoblastoma related gene
RB2/p130 in human cell lines and primary tumors. Cancer Research, 60: 383-389.
43. Caterina Cinti, Lorenzo Leoncini, Aggrey Nyongo, Filomena Ferrari, Stefano Lazzi, Cristiana Bellan,
Alessandra Zamparelli, Pier Paolo Claudio, Nadir Mario Maraldi, Piero Tosi and Antonio Giordano.
(2000): Genetic alterations of the retinoblastoma related gene RB2/p130 identify different pathogenetic
mechanism in and among Burkitt's lymphoma subtypes. American J. of Pathology, 156 (3): 751-760.
44. Claudio P.P., Caputi M., Giordano A. (2000): The Rb2/p130 gene: the latest weapon in the war
against lung cancer? Clin Canc. Research, 6 (3): 754-64.
45. Candace M. Howard, Pier Paolo Claudio, Antonio De Luca, Peter Stiegler, Francesco Paolo Jori,
Nabile M. Safdar, Mario Caputi, Kamel Khalili, and Antonio Giordano. (2000): Inducible pRb2/p130
expression and growth suppressive mechanisms: evidence of a pRb2/p130, p27Kip1, and cyclin E
Pier Paolo Claudio, M.D., Ph.D.
negative feedback regulatory loop. Cancer Research, 60: 2737-2744.
46. Perrotti, D., Iervolino, A., Cesi, V., Cirinna, M., Lombardini, S., Grassilli, E., Bonatti, S. Claudio,
P.P., Calabretta, B. (2000) BCR-ABL prevents c-jun-mediated and proteasome-dependent FUS (TLS)
proteolysis through a protein kinase CbetaII dependent pathway. Mol Cell Biol. 20(16): 6159-69.
47. Claudio, P.P. (2000) Immunohistochemical investigation of new suppressor oncogene p130 in oral
squamous cell carcinoma. Oral Oncology, Letter to the Editor 36(5): 497.
48. Cinti C., Claudio P.P., Howard, C.M., Neri L.M., De Luca A., Waterman J.L.F., Azzoni L., Giordano
A., Halazonetis T.D., Maraldi N.M. (2000): A serine 37 mutation associated with two missense mutations
at highly conserved regions of p53 induces -irradiation resistance affecting pro-apoptotic genes
expression. Oncogene, 19 (44): 5098-5106.
49. Pier Paolo Claudio, Peter Stiegler, Candace M. Howard, Cristiana Bellan, Corrado Minimo, Janusz
Rak, Al Kovatich, Paola De Fazio, Pietro Micheli, Mario Caputi, Robert Kerbel, Giovan Giacomo
Giordano, and Antonio Giordano. (2001): RB2/p130 gene enhanced expression down-regulates Vascular
Epithelial Growth Factor expression and inhibits Angiogenesis in vivo. Cancer Research, (62):462-68.
50. Claudio, P. P., Cinti, C., and Giordano, A. Application of the primer in situ DNA synthesis (PRINS)
technique to titer recombinant virus and evaluation of the efficiency of viral transduction, Anal Biochem.
291: 96-101., 2001.
51. Galderisi, U., Melone, M. A., Jori, F. P., Piegari, E., Di Bernardo, G., Cipollaro, M., Cascino, A.,
Peluso, G., Claudio, P. P., and Giordano, A. pRb2/p130 gene overexpression induces astrocyte
differentiation, Mol Cell Neurosci. 17: 415-25, 2001.
52. Zini, N., Trimarchi, C., Claudio, P. P., Stiegler, P., Marinelli, F., Maltarello, M. C., La Sala, D., De
Falco, G., Russo, G., Ammirati, G., Maraldi, N. M., Giordano, A., and Cinti, C. pRb2/p130 and p107
control cell growth by multiple strategies and in association with different compartments within the
nucleus, J Cell Physiol. 189: 34- 44, 2001.
53. Pier Paolo Claudio, Alessandra Zamparelli, Luigi Califano,Aldo Zupi, Cristiana Bellan, Corrado
Minimo, Candace M. Howard, Giovanna Carrillo, Pietro Micheli, Caterina Cinti, Lorenzo Leoncini,
Costantino Giardino, Antonio Giordano. Expression of Cell-Cycle Regulated Proteins pRB2/p130, p107,
E2F4, p27, and of pCNA in Salivary Gland Tumors. Prognostic and diagnostic implications. Rivista
Italiana di Chirurgia Maxillo Facciale Vol XII, 1: 37-48, 2001.
54. Francesco Papa, Salvatore Ferrara, Livia Felicetta, Giovanni Lavorgna, Margherita Matarazzo,
Stefania Staibano, Sabrina Troisi, and Pier Paolo Claudio. Mandibular metastatic hepatocellular
carcinoma: report of a case involving severe and uncontrollable hemorrhage. Anticancer Res. 21: 212130., 2001.
55. Pier Paolo Claudio. Asian-American variants of human papillomavirus 16 and risk for cervical
cancer: a case control study. J Natl Cancer Inst 2001; 93: 1325-1330. Commentary Basic Sciences, The
Women’s Oncology Review, 4: 357-358, 2001.
56. Claudio, P. P., Zamparelli, A., Garcia, F. U., Claudio, L., Ammirati, G., Farina, A., Bovicelli, A.,
Russo, G., Giordano, G. G., McGinnis, D. E., Giordano, A., and Cardi, G. Expression of Cell-Cycleregulated Proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in Prostatic Gland
Adenocarcinoma, Clin Cancer Res. 8: 1808-15., 2002.
57. Pucci, B., Claudio, P.P., Masciullo, V., Bellincampi, L., Terrioni, A., Khalili, K., Melino, G.,
Giordano, A. pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by
p73 up-regulation and Bcl2 down-regulation. Oncogene 21: 5897-5905, 2002.
58. Condorelli, G.L., Morisco, C., Latronico, M., Claudio, P.P., Dent, P., Tsichlis, P., Condorelli, G.,
Frati, G., Drusco, A., Croce, C.M., and Napoli C. TNF-α signal transduction in rat neonatal cardiac
myocytes: definition of pathways generating from the TNF-α receptor. FASEB, 16: 1732-37, 2002.
Pier Paolo Claudio, M.D., Ph.D.
59. Tonini, T., Hillson, C. and Claudio, P.P. Interview with the retinoblastoma family members: do they
help each other? J. Cell Physiol. 192, 2: 138-150, 2002.
60. Lazzi, S., Bellan, C., De Falco, G., Cinti, C., Ferrari, F., Nyongo, A., Claudio, P.P., Tosi, G.M., Vatti,
R., Gloghini, A., Carbone, A, Giordano, A., Leoncini, L., Tosi, P. Expression of RB2/p130 tumorsuppressor gene in AIDS-related non-Hodgkin's lymphomas: Implications for disease pathogenesis.
Human Pathol., 33, 7: 723-731, 2002.
61. Claudio, P.P., Tonini, T., Giordano, A. The retinoblastoma family: twins or distant cousins? Genome
Biol. 3: 9, REVIEWS3012, 2002.
62. Claudio PP, Giordano A. Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung
cancer. Methods Mol Med 2003: 75: 591-605.
63. Pier Paolo Claudio, Candace, M. Howard A controlled trial of a human papillomavirus type 16
vaccine. N Engl J Med 2002; 374:1645-51. Commentary, The Women’s Oncology Review, 3: 113-182003.
64. De Falco G., Bellan C., Lazzi S., Claudio P.P., La Sala D., Cinti C., Tosi P., Giordano A., Leoncini L.
The interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDSrelated neoplasms. Oncogene, 22; 6214-19, 2003
65. Tiziana Tonini, Francesca Rossi, Pier Paolo Claudio. Molecular basis of angiogenesis. Oncogene, 22:
6549-56, 2003.
66. Russo G, Claudio PP, Fu Y, Stiegler P, Yu Z, Macaluso M and Giordano A. RB2/p130 target genes in
non-small lung cancer identified by microarray analysis. Oncogene, 22; 6959-69, 2003.
67. Gaetano Romano, Pier Paolo Claudio, Tiziana Tonini, Antonio Giordano. Human immunodeficiency
virus type 1 (HIV-1) derived vectors: safety considerations and controversy over therapeutic applications.
The European J. of Dermatology, 13 (5): 424-9, 2003.
68. Claudio, P. P., Russo, G., Kumar, C. A., Minimo, C., Farina, A., Tutton, S., Nuzzo, G., Giuliante, F.,
Angeloni, G., Maria, V., Vecchio, F. M., Campli, C. D., and Giordano, A. pRb2/p130, vascular endothelial
growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma:
their clinical significance. Clin Cancer Res, 10: 3509-3517, 2004.
69. Tonini, T., Claudio, P. P., Giordano, A., and Romano, G. Transient production of retroviral- and
lentiviral-based vectors for the transduction of Mammalian cells. Methods Mol Biol, 285: 141-148, 2004.
70. Tonini, T., Claudio, P. P., Giordano, A., and Romano, G. Determination of Functional Viral Titer by
Drug-Resistance Colony Assay, Expression of Green Fluorescent Protein, and beta-Galactoside Staining.
Methods Mol Biol, 285: 149-154, 2004.
71. Tonini, T., Claudio, P. P., Giordano, A., and Romano, G. Retroviral and lentiviral vector titration by
the analysis of the activity of viral reverse transcriptase. Methods Mol Biol, 285: 155-158, 2004.
72. Tonini, T., Bagella, L., D'Andrilli, G., Claudio, P. P., and Giordano, A. Ezh2 reduces the ability of
HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A. Oncogene, 23: 4930-4937, 2004.
73. Russo G, Giordano A, Claudio P.P. RBL2 (retinoblastoma-like 2). Atlas Genet Cytogenet Oncol
Haematol. March 2004. URL : http://www.infobiogen.fr/services/chromcancer/Genes/RBL2ID443.html
74. Vattemi E., Claudio P.P. Gene therapy for lung cancer: practice and promise. Ann Ital Chir. 2004
May-Jun;75(3):279-89.
75. Giuseppe Russo, Alessandra Zamparelli, Candace M. Howard, Corrado Minimo, Cristiana Bellan,
Giovanna Carrillo, Luigi Califano, Lorenzo Leoncini, Antonio Giordano, and Pier Paolo Claudio.
Expression of Cell-Cycle Regulated Proteins pRB2/p130, p107, E2F4, p27, and of pCNA in Salivary
Gland Tumors. Prognostic and diagnostic implications. Clinical Cancer Research, 2005 May
1;11(9):3265-73.
Pier Paolo Claudio, M.D., Ph.D.
76. Gilberto Sammartino, Mariano Tia, Gaetano Marenzi, A.E. di Lauro, Elio D’Agostino, and Pier
Paolo Claudio. Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after
extraction of impacted mandibular third molars. JOMS, Jun;63(6):766-70, 2005.
77. Francesco Papa, Antonio Cortese, Maria Cristina Maltarello, Raffaele Sagliocco, Pietro Felice, and
Pier Paolo Claudio. Outcome of 50 consecutive sinus lift operations. BJOMS, Aug;43(4):309-13, 2005.
78. Vattemi E., and Claudio P.P. Current status of gene therapy for lung cancer. Drugs of the Future 30:
(10), 1017, 2005.
79. Giacinti L., Claudio P.P., Giordano A. Epigenetic Information and Estrogen Receptor Alfa
Expression in Breast Cancer. The Oncologist, 2006 Jan;11(1):1-8.
80. Merola E. Claudio PP, Giordano A. p53 and the malignant progression of Barrett's esophagus. J Cell
Physiol. Mar; 206(3):574-7, 2006.
81. Francesca Sanseverino, Rosa Santopietro, Michela Torricelli, Giuseppina D’Andrilli, Gabriele
Cevenini, Alessandro Bovicelli, Lorenzo Leoncini, Giovanni Scambia, Felice Petraglia, Antonio
Giordano and Pier Paolo ClaudiopRb2/p130 and VEGF expressions in endometrial carcinoma in relation
to angiogenesis and tumor histopathologic grade. Cancer Biol Ther. 2006 Jan 22;5(1).
82. Elettra Merola, Eliseo Mattioli, Corrado Minimo, Weineng Zuo, Carla Rabitti, Michele Cicala, Renato
Caviglia, Lucio Pollice, Antonio Giordano and Pier Paolo Claudio. Immunohistochemical evaluation of
pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27, and PCNA in Barrett’s Esophagus. Journal Cell
Physiology, 207(2): 512-9, 2006.
83. Vogiatzi, P, De Falco G., Claudio PP, Giordano A. How Does the Human RUNX3 Gene Induce
Apoptosis in Gastric Cancer? Latest Data, Reflections and Reactions. Cancer Biol Ther. (4):371-374,
2006.
84. Abbadessa G., Santoro A., and Claudio P.P. Meeting Report: 42nd Annual Meeting of the American
Society of Clinical Oncology (ASCO) June 2-6, 2006, Atlanta, GA. Drugs of the Future 31:(7), 2006.
85. Pier Paolo Claudio, Chiara Mariano, Sujatha Radhakrishnan, Kamel Khalili, Mahmut Safak, Antonio
Giordano, Shohreh Amini, and Bassel E Sawaya. Phosphorylation of p53 by cdk9 prevents HIV-1 gene
transcription and viral replication. Journal Cell Physiology 208(3): 602-612, 2006.
86. Genovese C., Trani D., Caputi M., Claudio, P.P. Cell cycle control and beyond: emerging roles for
the retinoblastoma gene family. Oncogene. 2006 Aug 28;25(38):5201-9.
87. Vogiatzi, P., Abbadessa, G., Cassone, M., Claudio, P.P. The limitless role of p53 in cell cycle
machinery: good news or bad news? Cancer Biol Ther. 2006 Sep; 5(9):1090-3.
88. Vattemi M, and Claudio PP. Adenoviral gene therapy in head and neck cancer. Drug News Perspect.
2006 Jul-Aug;19(6):329-37.
89. Howard, C.M., Forsberg F., Liu, J.B., Merton D.A., Minimo C., Pier Paolo Claudio Ultrasound
guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast
agents. Journal Cell Physiology 2006 Nov; 209 (2):413-21.
90. Paraskevi Vogiatzi, Marco Cassone, and Pier Paolo Claudio. On the road to personalizing gene
therapy in gastric cancer: proposals for transforming dreams into reality. Drug News Perspect. 2006
Nov;19(9):533-40.
91. Eliseo Mattioli, Paraskevi Vogiatzi, Ang Sun, Giovanni Abbadessa, Giulia Angeloni, Domenico
D’Ugo, Daniela Trani, John P. Gaughan, Fabio Maria Vecchio, Gabriele Cevenini, Roberto Persiani,
Antonio Giordano, and Pier Paolo Claudio Immunohistochemical analysis of pRb2/p130, VEGF, EZH2,
p53, p16 INK4A, p27KIP1, p21WAF1, Ki-67 expression patterns in gastric cancer. J Cell Physiol. 2007
Jan; 210(1):183-91.
92. Bagella, Tiziana Tonini, Giuliano Cottone, Pier Paolo Claudio, Marco G. Paggi, Antonio De Luca,
Pier Paolo Claudio, M.D., Ph.D.
Antonio Giordano. A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2
activity and cell cycle arrest. Oncogene, 2007 Mar 22;26(13):1829-39
93. De Falco, G., Leucci, E., Lenze, D., Piccaluga, PP, Claudio, PP, Onnis, A., Cerino, G., Nyagol, J.,
Mwanda, W., Bellan, C., Hummel, M., Pileri, S., Tosi, P., Stein, H., Giordano, A., Leoncini, L. Geneexpression analysis identifies novel RBL2/p130 target genes in endemic Burkitt's lymphoma cell lines
and primary tumors. Blood. 2007 Aug 15;110(4):1301-7.
94. Giovanni Abbadessa, Paraskevi Vogiatzi, Lorenza Rimassa and Pier Paolo Claudio. Antiangiogenic
drugs currently used for colorectal cancer: what other pathways can we target to prolong responses? Drug
News and Perspectives, June 2007, 20 (5), 1-7.
95. Antonio Graziano, Vincenzo Desiderio, and Pier Paolo Claudio. Stem cells in tissue engineering for
therapeutic use, a promising tool or an approachable reality? Drugs Future 31(12): 1117, 2006.
96. Candace M. Howard and Pier Paolo Claudio Meeting report of the 2006 Radiological Society of
North America (RSNA). Molecular imaging: Novel techniques that not only visualize cellular changes
driving disease processes before they become apparent anatomically, but also useful therapeutic tools for
multiple diseases? Drugs of the Future, 2007.
97. Emanuela Vattemi and Pier Paolo Claudio Advances and Perspectives of Gene- Based therapy for
Brest Cancer. Drugs Fut 32(6): 507, 2007.
98. Emanuela Vattemi and Pier Paolo Claudio Tumor Suppresor Genes as Cancer Therapeutics Drugs
News Perspectives Oct;20(8):511-20, 2007.
99. Paraskevi Vogiatzi, Pierpaolo Aimola, Scarano M. Irene and Pier Paolo Claudio. Epigenome: from
the control of cell growth to cancer. Drug News Perspectives Dec;20(10):627-33, 2007.
100. Gilberto Sammartino, Gaetano Marenzi, Candace Howard, Oreste Trosino, Corrado Minimo, Luigi
Califano, and Pier Paolo Claudio. Chondrosarcoma of the jaw: an anterior mandibular localization. A
case report with a four-year follow-up. Journal of Maxillofacial Surgery 2008 Nov;66(11):2349-55.
101. S. E. Kelly, Di Benedetto A., Valluri, J.V., Claudio, P.P. Selection and Proliferation of Stem Cells.
Gravitational and Space Biology, 2008.
102. Manuela Vattemi and Pier Paolo Claudio. The feasibility of Gene Therapy in the Treatment of
Head and Neck Cancer. Head and Neck Oncology. Invited Review Article. Head Neck Oncol. 2009 Jan
12;1(1):3.
103. Manuela Vattemi and Pier Paolo Claudio. CONTUSUGENE LADENOVEC. Monograph, Drugs
of the Future 2009, 34(3):1-6.
104. Adelaide Greco, Altomare DiBenedetto, Candace Howard, Sarah Kelly, Yulia Dementieva, Michele
Miranda, Arturo Brunetti, Marco Salvatore, Luigi Claudio, Devanand Sarkar, Paul B. Fisher, and Pier
Paolo Claudio. Eradication of therapy-resistant human prostate tumors using an ultrasound guided sitespecific Mda7/IL-24 cancer terminator virus. Molecular Therapy (in press, 2009).
105. Gilberto Sammartino, Mariano Tia, Gaetano Marenzi, Eva Gentile, and Pier Paolo Claudio. Could
PRP and resorbable membrane be considered an effective solution in the prevention of periodontal defects
following deep impacted lower third molar extraction? Journal of Maxillofacial Surgery. (in press, 2009).
106. Paraskevi Vogiatzi, Marco Cassone, Luigi Claudio, and Pier Paolo Claudio Targeted Therapy for
Hormone-Refractory Prostate Cancer: Looking Through New Lenses. Drugs News and Perspectives (in
press, 2009).
107. Vincenzo Desiderio, Antonio Graziano, Pierpaolo Aimola and Pier Paolo Claudio. Stem cells in
cancer therapy: from their role into pathogenesis to their use as therapeutic agents Drugs News and
Perspectives (in press, 2009).
Pier Paolo Claudio, M.D., Ph.D.
BOOK CHAPTERS:
1. De Luca A., Baldi A., Claudio P.P., Howard C.M., Campisi S., Giordano A., Condorelli G. (1995):
The retinoblastoma gene and its role in cancer and differentiation. In Future Trends in Endocrinology.
Ares-Serono Symposia Series-Frontiers in Endocrinology 14: 197-206.
2. Howard C.M., Claudio P.P., Carbone M., Giordano A. (1998): SV40 and Human Cancer. in Samuels,
S.W. and Upton, A.C. Genes, Cancer and Ethics In the Work Environment. OEM Press, Beverly, MA.
167-174.
3. Claudio P. P., Giordano A. (2000): RB1 and RB2. In Pass H.I., Mitchell J.B., Johnson D.H., Turrisi
A.T., Minna J.D. (Ed.) Lung Cancer: Principles and Practice. Lippincot Williams & Wilkins. 7: 133-155
4. Claudio PP, Giordano A. (2003): Preparation of retroviral vectors for cell cycle-targeted gene therapy
of lung cancer. In Barbara Driscoll (Ed.) Lung Cancer, volume II, Diagnostic and therapeutic methods and
reviews. Methods Mol Med. Humana Press. 75: 591-605.
5. Montella, M., Gallipoli, A., Lorusso, A., Creazzola, S., Claudio, P.P., D’Errico, G. (2003):
L’organizzazione della lotta contro i tumori. Capitolo 36. In Mazzeo, F., Forestieri, P. Ed. Piccin Nuova
Libraria Padova. Trattato di Chirurgia Oncologica. Vol 1, pag. 36.1-36.23.
6. Claudio, F., Claudio, P.P. (2003): I tumori della lingua. Capitolo 36. In Mazzeo, F., Forestieri, P. Ed.
Piccin Nuova Libraria Padova. Trattato di Chirurgia Oncologica. Vol 2, pag. 39.1-39.42.
7. Tiziana Tonini, Pier Paolo Claudio, Antonio Giordano and Gaetano Romano. (2004): in Methods in
Molecular Biology. Cell cycle control and dysregulation protocols. Part IV RETROVIRIDAE-BASED
VECTORS: PROTOCOLS FOR LENTIVIRAL – AND RETROVIRAL-MEDIATED GENE
TRANSFER TO ENGINEER CELL CULTURE SYSTEMS. Transient production of retroviral-and
lentiviral-based vectors for the transduction of mammalian cells. Humana Press, Chapter 18.
8. Tiziana Tonini, Pier Paolo Claudio, Antonio Giordano and Gaetano Romano. (2004): in Methods in
Molecular Biology. Cell cycle control and dysregulation protocols. Part IV RETROVIRIDAE-BASED
VECTORS: PROTOCOLS FOR LENTIVIRAL – AND RETROVIRAL-MEDIATED GENE
TRANSFER TO ENGINEER CELL CULTURE SYSTEMS. Determination of functional viral titer by
drug-resistance colony assay, expression, expression of green fluorescent protein, and beta-galactosidase
staining. Humana Press, Chapter 19.
9. Tiziana Tonini, Pier Paolo Claudio, Antonio Giordano and Gaetano Romano. (2004): in Methods in
Molecular Biology. Cell cycle control and dysregulation protocols. Part IV RETROVIRIDAE-BASED
VECTORS: PROTOCOLS FOR LENTIVIRAL – AND RETROVIRAL-MEDIATED GENE
TRANSFER TO ENGINEER CELL CULTURE SYSTEMS. Retroviral and lentiviral vector titration by
the analysis of the activity of viral reverse transcriptase. Humana Press. Chapter 20.
10. Pier Paolo Claudio, Antonio Giordano. Angiogenesis and cancer. Practical Medical Oncology . Ed
M. Lopez. Second Edition 2005.
11. Molecular Pathology of Gynecological Cancer. Part VII: The multidisciplinary therapeutic approach
to gynecological cancer in the new millennium. Chapter 13: The Holistic Approach to Female Cancer
Patients. Alessandro Bovicelli, Pier Paolo Claudio and Antonio Giordano. Humana Press.
12. Claudio P.P. and Denning D. (2007): Nasopharyngeal carcinoma. In Cancer Research, an
encyclopedic reference book. Springer Ed. 615-618.
13. Claudio P.P. and Vogiatzi P. Regulation of cell cycle by retinoblastoma tumor suppressors. In:
Signal Transduction: Pathways, Mechanisms and Diseases. Springer Ed. (2009, in press).
BOOKS:
1. Claudio P.P., Savastano G. (1992): I tumori cutanei della faccia. Plastiche ricostruttive dopo exeresi.
(Cutaneous tumors of the face. Reconstructive surgery after ablation) Ed. Scientifiche Italiane. Napoli, 1 160.
2. Califano L., Claudio P.P. (1995): I tumori della parotide. (Parotid tumors) Ed. Scientifiche Italiane.
Napoli, 1-148.