A New Vinyl Selenone-Based Domino Approach to Spirocyclopropyl

Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.
This journal is © The Royal Society of Chemistry 2016
A New Vinyl Selenone-Based Domino Approach to Spirocyclopropyl
Oxindoles Endowed with Anti-HIV RT Activity
M. Palomba,a L. Rossi,a L. Sancineto,a E. Tramontano,c A. Corona,c L. Bagnoli,a C. Santi,a C.
Pannecouque,b O. Tabarrini,a F. Marinia*
a. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo 1, 06123
Perugia, Italy.
b. KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy,
Rega Institute for Medical Research, B-3000 Leuven, Belgium.
c. Dipartimento di Scienze della Vita e dell’Ambiente, Cittadella Universitaria di Monserrato SS554 –
09042, Monserrato (Cagliari)
Supporting information contents
NMR Spectra…………………………………………………………………………….
S2
HETCOR and NOESY experiments……………………………………………………
S23
S1
H
O
N
Me
3a d.r. 93:7
S2
Cl
H
O
N
Me
3b d.r. 94:6
S3
F
H
O
N
Me
3c d.r. 96:4
S4
H
O
Cl
N
Me
3d d.r.>99:1
S5
Me
H
O
N
Me
3e d.r. 90:10
S6
O2N
H
O
N
Me
3f d.r. 98:2
S7
Cl
H
O
N
Me
3g d.r.>99:1
S8
Me
H
O
N
Me
3h d.r. 96:4
S9
H
O
Me
N
Me
3i d.r. 92:8
S10
H
O
Cl
N
Bn
3j d.r. 91:9
S11
H
O
N
H
3k d.r. 93:7
S12
Cl
H
O
N
H
3l d.r.>99:1
S13
F
H
O
N
H
3m d.r.>99:1
S14
Me
H
O
N
H
3n d.r. 98:2
S15
H
O
Br
N
H
3o d.r.>99:1
S16
Me
H
O
N
H
3p d.r. >99:1
S17
O
N
Me
3q
S18
Me
O
N
Me
3r
S19
Me
O
N
Me
4r
S20
C6H13
O
N
Me
3s
S21
C6H13
O
N
Me
4s
S22
NOESY of compound 3r (400MHz, C6D6)
NOESY of compound 4r (400MHz, CDCl3)
S23
HETCOR of compound 3s (400MHz, C6D6)
HETCOR of compound 4s (400MHz, C6D6)
S24
NOESY of compound 3s (400MHz, C6D6)
NOESY of compound 4s (400MHz, C6D6)
S25