Diapositiva 1

ANALYSIS OF UBCH10
EXPRESSION REPRESENTS A
USEFUL TOOL FOR THE
DIAGNOSIS AND THERAPY
OF LUNG CANCER
Donato G., Conforti F., Zuccalà V., Amorosi A..
U.O. di Anatomia Patologica
Università degli Studi di Catanzaro Magna Græcia
The expression of UbcH10 gene, that codes
for a protein that belongs to the ubiquitinconjugating enzyme family, as a valid
indicator of the proliferative and
aggressive status of tumors of different
origin.
There is no expression of UBCH10 in normal
lung.
Normal lung
Therefore, to look for possible tools to be
used as diagnostic markers in lung
neoplasias, we have investigated UbcH10
expression in low grade and high grade
lungs tumors by immunohistochemistry.
Non-small cell lung cancer
Small cell lung cancer
Our data indicate a correlation between
UbcH10 expression and the histological
grade of the lungs tumors. It is possible
that up-regulation of UbcH10 play a role in
progression of lungs tumors.
Finally, since proteasome inhibitors have
been, recently, considered as possible
drugs in the chemotherapy of various
tumors our results would suggest new
perspectives for the treatment of lung
malignancies based on the suppression of
the UbcH10 function by these drugs.