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European Respiratory Society Annual Congress 2012
European Respiratory Society Annual Congress 2012 Abstract Number: 2359 Publication Number: P1507 Abstract Group: 4.3. Pulmonary Circulation and Pulmonary Vascular Disease Keyword 1: Pulmonary hypertension Keyword 2: Quality of life Keyword 3: Exercise Title: Exercise tests and anxiety independently reflect physical quality of life in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension Dr. Michael 16751 Halank [email protected] MD 1, Dr. Franziska 16752 Einsle [email protected] 2, Dr. Stephanie 16753 Christoph [email protected] MD 3, Dr. Hinrich 16754 Bremer '[email protected]' MD 4, Prof. Dr Ralf 16767 Ewert [email protected] MD 5, Prof. Dr Heinrike 16777 Wilkens [email protected] MD 6, Prof. Dr Joachim 16778 Meyer [email protected] MD 7, Dr. Hans-Juergen 16795 Seyfarth [email protected] MD 8, Dr. Martin 16803 Kolditz [email protected] MD 1, Gesine 16818 Wieder [email protected] 2, Prof. Dr Gert 16820 Hoeffken [email protected] MD 1 and Prof. Dr Volker 16825 Koellner [email protected] MD 9. 1 Internal Medicine I, University Hospital Carl Gustav Carus of TU Dresden, Germany, 01307 ; 2 Institute of Clinical Psychology and Psychotherapy, Technical University, Dresden, Germany, 01307 ; 3 Department of Nuclear Medicine, University Hospital Carl Gustav Carus of TU Dresden, Germany, 01307 ; 4 Internal Medicine, Schwarzwald-Baar Klinikum, Donaueschingen, Germany ; 5 Internal Medicine/Pulmonology, Ernst-Moritz-Arndt University, Greifswald, Germany ; 6 Internal Medicine/Pulmonology, Saarland University Hospital, Homburg/Saar, Germany ; 7 Internal Medicine/Pulmonology and Gastroenterology, Klinikum Harlaching, München, Germany ; 8 Pulmonary Medicine, University Hospital, Leipzig, Germany and 9 Institute of Psychosomatic Medicine, Saarland University Hospital, Homburg/Saar, Greenland . Body: Background: Up to now, only few data existed evaluating quality of life in patients with PAH and/or CTEPH. Question: To describe the association between anxiety, depression, cardiopulmonary hemodynamics, and exercise parameters with physical quality of life (QoL). Methods: Patients with PAH and/or CTEPH performed a 6 minute walk test, cardiopulmonary exercise testing (CPET) and right heart catheterization and completed 3 QoL questionnaires (SF36, SRGQ and MacNew). Hospital Anxiety and Depression Scale (HADS) was used to assess psychological constructs like anxiety and depression. Results: 63 PAH und 22 CTEPH patients were prospectively included. Peak oxygen uptake (VO2 peak) during CPET was 13±4 ml/min/kg and 6 minute walk distance (6MWD) was 325±127 m. After multivariate analysis anxiety showed an independent association with activity, impact, and total scores in SGRQ and with emotional, physical, social and total scores in MacNew and with mental score in SF36. There was an independent correlation between depression and physical, mental and symptom scores in SF-36. Peak VO2 showed an independent association with all above mentioned subscales in SGRQ and with physical and mental QoL in SF36, whereas 6MWD was associated with all above mentioned scores of the MacNew and the symptom score of SF36. Conclusion: Peak VO2 and 6MWD reflect quality of life in patients with PAH and/or CTEPH. In addition, anxiety and depression showed a strong association with mental and physical QoL underlining the need for awareness of these disorders.