Hemorrhage Lysis Endpoint Coagulation Sequence

HET-CAM BRD: Appendix H1
March 2006
HET-CAM Test Scores for Dimethylformanide
Sequence
Number
183
185
186
188
189
190
191
192
193
194
196
198
201
202
203
205
207
208
209
211
212
213
215
217
230
231
232
233
234
235
236
237
238
240
241
242
243
244
245
251
252
253
Hemorrhage
Endpoint Score
Lysis Endpoint
Score
Coagulation
Endpoint Score
In vitro score
Egg 1 Egg 2 Egg 3 Egg 1 Egg 2 Egg 3 Egg 1 Egg 2 Egg 3 Egg 1 Egg 2 Egg 3
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
4.27
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
6.74
6.91
6.93
6.95
6.86
6.93
6.98
6.93
6.86
6.77
6.95
6.91
6.86
6.98
6.93
6.93
6.91
6.91
6.95
6.93
6.93
6.91
6.88
6.88
6.91
6.98
6.95
6.98
6.95
6.98
6.95
6.98
6.95
6.98
6.98
6.93
6.98
6.98
6.98
6.98
6.95
6.95
6.86
6.86
6.74
6.88
6.84
6.91
6.91
6.98
6.95
6.84
6.93
6.88
6.95
6.93
6.91
6.95
6.95
6.91
6.93
6.95
6.98
6.93
6.81
6.91
6.88
6.98
6.98
6.98
6.93
6.95
6.98
6.98
6.95
6.98
6.95
6.95
6.95
6.95
6.95
6.95
6.95
6.98
6.88
6.84
6.88
6.88
6.93
6.91
6.91
6.95
6.93
6.84
6.91
6.93
6.93
6.93
6.93
6.98
6.95
6.93
6.95
6.95
6.93
6.93
6.79
6.95
6.93
6.98
6.95
6.93
6.95
6.95
6.98
6.95
6.93
6.95
6.98
6.95
6.95
6.93
6.95
6.86
6.93
6.93
H-5
8.79
8.61
8.67
8.49
8.55
8.79
8.82
8.76
8.88
8.88
8.79
8.76
8.58
8.85
8.76
8.85
8.76
8.61
8.82
8.79
8.85
8.79
8.76
8.79
8.91
8.85
8.85
8.88
8.82
8.88
8.88
8.67
8.85
8.88
8.91
8.85
8.91
8.94
8.91
8.85
8.88
8.91
8.85
8.58
8.52
8.25
8.58
8.79
8.82
8.85
8.94
8.94
8.67
8.67
8.70
8.79
8.76
8.88
8.85
8.67
8.76
8.88
8.85
8.73
8.70
8.79
8.91
8.88
8.88
8.82
8.85
8.85
8.88
8.79
8.88
8.88
8.85
8.88
8.91
8.88
8.88
8.85
8.85
8.85
8.85
8.64
8.37
8.34
8.73
8.76
8.82
8.76
8.91
8.88
8.76
8.73
8.67
8.73
8.79
8.88
8.88
8.76
8.79
8.85
8.85
8.82
8.67
8.82
8.94
8.88
8.85
8.82
8.85
8.85
8.91
8.85
8.85
8.85
8.91
8.88
8.88
8.88
8.88
8.73
8.85
8.76
15.53
15.52
15.60
15.44
15.41
15.72
15.80
15.69
15.74
15.65
15.74
15.67
15.44
15.83
15.69
15.78
15.67
19.78
15.77
15.72
15.78
15.70
15.64
15.67
15.82
15.83
15.80
15.86
15.77
15.86
15.83
15.65
15.80
15.86
15.89
15.78
15.89
15.92
15.89
15.83
15.83
15.86
15.71
15.44
15.26
15.13
15.42
15.70
15.73
15.83
15.89
15.78
15.60
15.55
15.65
15.72
15.67
15.83
15.80
15.58
15.69
15.83
15.83
15.66
15.51
15.70
15.79
15.86
15.86
15.80
15.78
15.80
15.86
15.77
15.83
15.86
15.80
15.83
15.86
15.83
15.83
15.80
15.80
15.83
15.73
15.48
15.25
15.22
15.66
15.67
15.73
15.71
15.84
15.72
15.67
15.66
15.60
15.66
15.72
15.86
15.83
15.69
15.74
15.80
15.78
15.75
15.46
15.77
15.87
15.86
15.80
15.75
15.80
15.80
15.89
15.80
15.78
15.80
15.89
15.83
15.83
15.81
15.83
15.59
15.78
15.69
HET-CAM BRD: Appendix H1
March 2006
HET-CAM Test Scores for Dimethylformanide
Sequence
Number
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
277
278
279
280
282
1A1
1B
2A
2B
3A
4A
4B
6A
8A-10A
11A
133
16-17-18
Hemorrhage
Endpoint Score
Lysis Endpoint
Score
Coagulation
Endpoint Score
In vitro score
Egg 1 Egg 2 Egg 3 Egg 1 Egg 2 Egg 3 Egg 1 Egg 2 Egg 3 Egg 1 Egg 2 Egg 3
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
3.48
3.35
2.98
3.77
2.93
3.20
3.62
2.02
3.97
3.38
4.20
4.07
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
3.63
3.15
2.72
3.98
3.18
3.33
3.47
2.58
2.60
3.92
3.97
3.95
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
0.00
3.38
4.02
3.18
3.98
3.18
3.38
3.58
3.97
3.02
3.82
4.00
3.80
6.95
6.93
6.95
6.91
6.98
6.95
6.95
6.98
6.95
6.95
6.95
6.98
6.95
6.95
6.95
6.95
6.93
6.95
6.91
6.93
6.95
6.95
6.86
6.95
6.93
6.93
6.95
6.81
6.65
5.72
6.56
6.42
6.46
6.56
6.70
6.65
6.84
6.79
6.84
6.88
6.93
6.95
6.93
6.95
6.88
6.95
6.95
6.95
6.91
6.98
6.95
6.93
6.95
6.95
6.95
6.95
6.93
6.98
6.98
6.91
6.98
6.91
6.91
6.93
6.95
6.91
6.74
6.74
6.23
6.58
6.51
6.49
6.70
4.90
6.88
6.93
6.86
6.88
6.91
6.93
6.93
6.95
6.95
6.95
6.93
6.93
6.93
6.95
6.98
6.95
6.79
6.93
6.95
6.95
6.95
6.93
6.95
6.93
6.95
6.95
6.93
6.95
6.93
6.81
6.91
6.79
6.67
6.39
6.72
6.60
6.63
6.67
5.86
6.91
6.91
6.88
6.77
1
8.88
8.82
8.88
8.82
8.88
8.88
8.88
8.91
8.88
8.88
8.88
8.91
8.85
8.82
8.88
8.91
8.85
8.82
8.73
8.82
8.88
8.91
8.73
8.82
8.85
8.85
8.88
8.82
8.88
8.67
8.79
8.88
8.76
8.73
8.76
8.76
8.73
8.70
8.73
8.73
8.76
8.85
8.85
8.82
8.76
8.85
8.85
8.85
8.85
8.85
8.85
8.82
8.85
8.91
8.88
8.88
8.85
8.85
8.88
8.79
8.88
8.82
8.79
8.79
8.88
8.82
8.82
8.91
8.70
8.82
8.79
8.82
8.79
8.82
8.82
8.85
8.79
8.79
8.82
8.85
8.85
8.85
8.85
8.91
8.82
8.82
8.88
8.85
8.88
8.88
8.61
8.85
8.88
8.88
8.91
8.85
8.85
8.85
8.91
8.88
8.85
8.85
8.85
8.70
8.85
8.85
8.85
8.70
8.88
8.76
8.82
8.82
8.88
8.88
8.82
8.88
8.67
15.83
15.75
15.83
15.73
15.86
15.83
15.83
15.89
15.83
15.83
15.83
15.89
15.80
15.77
15.83
15.86
15.78
15.77
15.64
15.75
15.83
15.86
15.59
15.77
15.78
15.78
15.83
19.11
18.88
17.37
19.12
18.23
18.42
18.91
17.48
19.38
18.95
19.69
19.64
15.61
15.69
15.80
15.78
15.77
15.64
15.80
15.80
15.80
15.76
15.83
15.80
15.75
15.80
15.86
15.83
15.83
15.78
15.83
15.86
15.70
15.86
15.73
15.70
15.72
15.83
15.73
19.19
18.80
17.65
19.38
18.48
18.64
18.96
16.30
18.30
19.70
19.62
19.62
15.73
15.78
15.78
15.80
15.80
15.86
15.75
15.75
15.81
15.80
15.86
15.83
15.40
15.78
15.83
15.83
15.86
15.78
15.80
15.78
15.86
15.83
15.78
15.80
15.78
15.51
15.76
19.02
19.54
18.27
19.58
18.54
18.83
19.07
18.71
18.81
19.55
19.76
19.24
Test Method Data 183 to 282 represent studies where a Test Substance Applicator was used and the hemorrhage endpoint was evaluated inside of the Test Substance Applicator.
2
Test Method Data 1A to 11A represent studies where a Test Substance Applicator was used and the hemorrhage endpoint was evaluated outside of the Test Substance Applicator.
3
Test Method Data 133 to 16-17-18 represent studies where a Test Substance Applicator was not used.
H-6