CURRICULUM gandini

CURRICULUM DIDATTICO-SCIENTIFICO DEL PROF. ORIETTA GANDINI
DATI PERSONALI
Nome e Cognome
Orietta Gandini
Luogo e data di nascita:
Milano 06/08/1961
Stato Civile: vedova
Dipartimento
Medicina Molecolare
Indirizzo
Telefono uff./lab./mobile
064451286
3280033401
0649979567
E-mail
[email protected]
Settore Scientifico-Disciplinare: MED/46
ATTUALE POSIZIONE
Ricercatore Equiparato
CARRIERA E TITOLI
1988: Laurea in Medicina e Chirurgia presso l'Università degli Studi di Roma "La Sapienza"
1989: Esame di Stato per l'abilitazione alla libera professione di Medico Chirurgo presso
l'Università degli Studi di Roma "La Sapienza"
1992-1995: Visiting Associated, presso il Laboratory of Reproductive and Developmental
Toxicology, (Direttore Dr Kenneth Korach) National Institute of Enviromental Health
Sciences ,Research Triangle Park, North Carolina USA
1994: Specializzazione in Endocrinologia e Malattie Metaboliche presso l'Università degli studi di
Roma "La Sapienza"
1989-2003: Funzionario Tecnico equiparato al personale ospedaliero con la qualifica di “Dirigente”
presso il Dipartimento di Medicina Sperimentale, Patologia Generale, Università degli Studi
Roma "La Sapienza"
20.10.2003: inquadrata nella Categoria EP
22.09.2004: inquadrata ai fini delle funzioni didattiche, ai sensi della legge n. 370/99, nel settore
scientifico –disciplinare MED/46
2004-oggi: Dirigente medico in servizio presso il Laboratorio DEA, Policlinico “Umberto I” Roma
2011: Master In Prevezione e Assistenza a Sovrappeso, Obesita’ e Disturbi dell’alimentazione
ATTIVITA’ DIDATTICA
2004-2010: incarico di insegnamento in Patologia Generale (ivi compresa Terminologia medica)
presso la Facoltà di Farmacia Università della “Sapienza” Roma, Corso di Informazione
Scientifica sul Farmaco (8CFU)
2010-2015: incarico di insegnamento in Patologia Generale (ivi compresa Terminologia medica)
presso la Facoltà di Medicina e Farmacia Università della “Sapienza” Roma, Corso di Scienze
Farmaceutiche Applicate (6CFU)
ATTIVITA’ SCIENTIFICA
Conta e caratterizzazione molecolare delle cellule tumorali circolanti in pazienti affetti da neoplasie
solide
Analisi dei meccanismi di farmacoresistenza delle cellule tumorali circolanti in pazienti oncologici
sottoposti a chemioterapia
Studio del danno endoteliale in pazienti obesi attraverso un’analisi quantitativa delle cellule
endoteliali circolanti
ATTIVITA’ ASSISTENZIALE
Dirigente Medico in servizio presso il Laboratorio DEA, Policlinico “Umberto I” Roma
PUBBLICAZIONI SCIENTIFICHE
Gazzaniga P, Raimondi C, Gradilone A, Biondi Zoccai G, Nicolazzo C, Gandini O, Longo F, Tomao
S, Lo Russo G, Seminara P, Vincenzi B, Chimenti I, Cristofanilli M, Frati L, Cortesi E.
Circulating tumor cells in metastatic colorectal cancer: do we need an alternative cutoff J Cancer Res
Clin Oncol. 2013 Aug;139(8):1411-6. Epub 2013 Jun 5
Gazzaniga P, Gianni W, Raimondi C, Gradilone A, Lo Russo G, Longo F, Gandini O, Tomao S,
Frati L. Circulating tumor cells in high-risk nonmetastatic colorectal cancer. Tumour Biol. 2013 Mar
29.
Gazzaniga P, Gradilone A, de Berardinis E, Busetto GM, Raimondi C, Gandini O., Nicolazzo C,
Petracca A, Vincenzi B, Farcomeni A, Gentile V, Cortesi E, Frati L. (2012). Prognostic value of
circulating tumor cells in nonmuscle invasive bladder cancer: a CellSearch analysis. ANNALS OF
ONCOLOGY, vol. 23; p. 2352-2356, ISSN: 0923-7534, doi: 10.1093/annonc/mdr619A.
A. Gradilone, G, Naso, C. Raimondi, E. Cortesi, Gandini O., B. Vincenzi, R. Saltarelli, E.
Chiapparino, F.Spremberg, M. Cristofanilli, L.Frati, A.M. Aglianò, And P. Gazzaniga (2011).
Circulating Tumor Cells (CTCs) In Metastatic Breast Cancer (Mbc): Prognosis, Drug Resistance
And Phenotypic Characterization. Annals Of Oncology, Vol. 22; P. 86-92, Issn: 0923-7534
Paola Gazzaniga, Giuseppe Naso, Cristina Raimondi, Angela Gradilone, Antonella Palazzo, Gandini
O., Arianna Petracca, Chiara Nicolazzo, Enrico Cortesi, Luigi Frati (2011). Circulating tumor cells
count and characterization in a male breast cancer patient. CANCER BIOLOGY & THERAPY, vol.
12; p. 379-382, ISSN: 1538-4047, doi: 10.4161/cbt.12.5.16304
Gradilone A, Raimondi C, Nicolazzo C, Petracca A, Gandini O., Vincenzi B, Naso G, Aglianò Am,
E. Cortesi, Gazzaniga P (2011). Circulating tumor cells lacking cytokeratin in breast cancer: the
importance of being mesenchymal. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,
vol. 15; p. 1066-1070, ISSN: 1582-1838, doi: 10.1111/j.1582-4934.2011.01285.x.
Gazzaniga P, Naso G, Gradilone A, Cortesi E, GANDINI O., Gianni W, Fabbri MA, Vincenzi B, di
Silverio F, Frati L, Aglianò AM, Cristofanilli M (2010). Chemosensitivity profile assay of circulating
cancer cells: prognostic and predictive value in epithelial tumors. INTERNATIONAL JOURNAL
OF CANCER, vol. 126; p. 2437-2447, ISSN: 0020-7136, doi: 10.1002/ijc.24953
Gradilone A, Pulcinelli Fm, Lotti Lv, Trifirò E, Martino S, Gandini O., Gianni W, L. Frati, Aglianò
Am, Gazzaniga P (2008). Celecoxib Upregulates Multidrug Resistance Proteins In Colon Cancer:
Lack Of Synergy With Standard Chemotherapy. Current Cancer Drug Targets, Vol. 8; P. 414-420,
Issn: 1568-0096, Doi: 10.2174/156800908785133178
Stigliano A, Gandini O., L. Cerquetti, Gazzaniga P, Misiti S, Monti S, Gradilone A, Falasca P, Poggi
M, Brunetti E, Aglianò Am, Toscano V (2007). Increased Metastatic Lymph Node 64 And Cyp17
Expression Are Associated With High Stage Prostate Cancer. Journal Of Endocrinology, Vol.
194(1); P. 55-61, Issn: 0022-0795, Doi: 10.1677/Joe-07-0131
Gradilone A, Gazzaniga P, E. Cigna, Vasaturo F, Vincenzi B, Gandini O., Silvestri I, Ribuffo D,
Scarpa S, Scuderi N, Agliano Am (2007). Fibronectin And Laminin Expression In Sentinel Lymph
Nodes Of Patients With Malignant Melanoma. British Journal Of Dermatology, Vol. 157(2); P. 398401, Issn: 0007-0963, Doi: 10.1111/J.1365-2133.2007.07995.X
Gradilone A, Silvestri I, S. Scarpa, Morrone S, Gandini O., Pulcinelli Fm, Gianni W, Frati L,
Agliano Am, Gazzaniga P (2007). Failure Of Apoptosis And Activation On Nf Kappa B By
Celecoxib And Aspirin In Lung Cancer Cell Lines. Oncology Reports, Vol. 17(4); P. 823-828, Issn:
1021-335x
P. Gazzaniga, Silvestri I, Gradilone A, Scarpa S, Morrone S, Gandini O., Gianni W, Frati L, Agliano'
Am (2007). Gemcitabine-Induced Apoptosis In 5637 Cell Line: An In-Vitro Model For High-Risk
Superficial Bladder Cancer. Anti-Cancer Drugs, Vol. 18; P. 179-185, Issn: 0959-4973, Doi:
10.1097/Cad.0b013e328010ef47
Gazzanigap, Nofroni I, Gandini O., I. Silvestri, Frati L, Agliano' Am, Gradilone A (2005). Tenascin
C And Epidermal Growth Factor Receptor As Markers Of Circulating Tumoral Cells In Bladder And
Colon Cancer. Oncology Reports, Vol. 14; P. 1199-1202, Issn: 1021-335x
Marchese R, Muleti A, Brozzetti S, Gandini O., Brunetti E, French D (2004). Low Value Of
Detection Of Kras2 Mutations In Circulating Dna To Differentiate Chronic Pancreatitis To
Pancreatic Cancer. British Journal Of Cancer, Vol. 90; P. 2243-2243, Issn: 0007-0920, Doi:
10.1038/Sj.Bjc.6601854
Gazzaniga P, Gradilone A, Giuliani L, Gandini O., I. Silvestri, Nofroni I, Saccani G, Frati L, Aglianò
A M (2003). Expression And Prognostic Significance Of Livin, Survivin And Other ApoptosisRelated Genes In The Progression Of Superficial Bladder Cancer. Annals Of Oncology, Vol. 14; P.
85-90, Issn: 0923-7534, Doi: 10.1093/Annonc/Mdg002
Gandini O., Santulli M, Cardillo Mr, Stigliano A, Toscano V (2003). Dd3, A Very Sensitive And
Specific Marker To Detect Prostate Tumors. Cancer Research, Vol. 63(15); P. 4747-4747, Issn:
0008-5472
Gradilone A, Gazzaniga P, I. Silvestri, Gandini O., Trasatti L, Lauro S, Frati L, Aglianò A M (2003).
Detection Of Ck 19, Ck 20 And Egfr Mrnas In Peripheral Blood Of Carcinoma Patients : Correlation
With Clinical Stage Of Disease. Oncology Reports, Vol. 10 ; P. 217-222, Issn: 1021-335x
Gandini O., Luci L., Stigliano A., Lucera R., Di Silverio F., V. Toscano, Cardillo M.R. (2003). Is
Dd3 A New Prostate-Specific Gene?. Anticancer Research, Vol. 23; P. 305-308, Issn: 0250-7005
Giacomelli L, Gianni W, Belfiore C, Gandini O., Repetto L, Filippini A, Frati L, Aglianò Am,
Gazzaniga P. (2003). Persistence Of Epidermal Growth Factor Receptor And Interleukin 10 In Blood
Of Colorectal Cancer Patients After Surgery Identifies Patients With High Risk To Relapse. Clinical
Cancer Research, Vol. 9; P. 2678-2682, Issn: 1078-0432
P. Gazzaniga, Gandini O., Giuliani L, Magnanti M, Gradilone A, Silvestri I, Gianni W, Gallucci M,
Frati L, Agliano’ Am (2001). Detection Of Epidermal Growth Factor Receptor Mrna In Peripheral
Blood: A New Marker Of Circulating Neoplastic Cells In Bladder Cancer Patients. Clinical Cancer
Research, Vol. 7; P. 577-583, Issn: 1078-0432
L. Giacomelli, W. Gianni, C. Belfiore, Gandini O., L. Repetto, A. Filippini, L. Frati, A.M. Aglian
And P. Gazzaniga (2001). Persistence Of Egfr And Il-10 In Blood Of Colorectal Cancer Patients
After Surgery Identifies Patients With High Risk To Relapse. Clinical Cancer Research, Vol. 23; P.
305-308, Issn: 1078-0432
Magnanti M., Gismondi A., Gandini O., Rossi F.M., P. Michetti, Santiemma V., Morrone S (2001).
Integrin Pattern And Effect On Contraction In Cultured Testicular Peritubular Myoid Cells.
American Journal Of Reproductive Immunology, Vol. 45; P. 21-27, Issn: 1046-7408, Doi:
10.1111/J.8755-8920.2001.450104.X
Cardillo Mr, Lazzereschi D, Gandini O., Di Silverio F, Colletta G (2001). Transforming Growth
Factor-Beta Pathway In Human Renal Cell Carcinoma And Surrounding Normal-Appearing Renal
Parenchyma. Analytical And Quantitative Cytology And Histology, Vol. 23; P. 109-117, Issn: 08846812
Marchesi M, Biffoni M, Faloci C, Cresti R, Mariotti F, Gandini O. (2001). [Familial Papillary
Carcinoma Of The Thyroid: Biogenetic Identification And Clinical Assessment Of 4 Families].
Annali Italiani Di Chirurgia, Vol. 72; P. 267-272, Issn: 0003-469x
Magnanti M., Gandini O., Giuliani L., Gazzaniga P., Marti Hh., Gradilone A., Frati L., A. Agliano',
Gassmann M. (2001). Erythropoietin Expression In Primary Rat Sertoli And Peritubular Myoid
Cells. Blood, Vol. 98 (9); P. 2872-2874, Issn: 0006-4971, Doi: 10.1182/Blood.V98.9.2872
Magnanti M, Giuliani L, Gandini O., Gazzaniga P, Santiemma V, Ciotti M, Saccani G, Frati L,
Aglianò Am (2000). Follicle-Stimulating Hormone, Testosterone, And Hypoxia Differentially
Regulate Udp-Glucuronosyltransferase 1 Isoforms Expression In Rat Sertoli And Peritubular Myoid
Cells. Journal Of Steroid Biochemistry And Molecular Biology, Vol. 74; P. 149-155, Issn: 09600760, Doi: 10.1016/S0960-0760(00)00095-9
Gazzaniga P, Gandini O., Gradilone A, Silvestri I, Giuliani L, Magnanti M, Gallucci M, Saccani G,
Frati L, Agliano Am (1999). Detection Of Basic Fibroblast Growth Factor Mrna In Urinary Bladder
Cancer: Correlation With Local Relapses. International Journal Of Oncology, Vol. 14; P. 1123-1127,
Issn: 1019-6439
Gandini O., Celi F. S., Magnanti M, P. Gazzaniga, Silvestri I, Conti B, Giuliani L., Mentuccia D,
Aglianò A. M. (1999). A Rapid, Simple, And Inexpensive Step Facilitates Rna Extraction From
Whole Blood Cells. Laboratory Investigation, Vol. 79 (12); P. 1731-1732, Issn: 0023-6837
Gazzaniga P, Gradilone A, Silvestri I, Gandini O., Giuliani L, Vincenzoni A, Gallucci M, Frati L, A.
Agliano' (1998). Variable Levels Of Bcl-2, Bcl-X And Bax Mrna In Bladder Cancer Progression.
Oncology Reports, Vol. 5; P. 901-904, Issn: 1021-335x
P. Gazzaniga, A. Gradilone, I. Silvestri, Gandini O., M. Napolitano, R. Vercillo, A. Vincenzoni, M.
Gallucci, L. Frati, A.M. Agliano' (1998). High Levels Of Transforming Growth Factor-Alpha (TgfAlpha) Mrna May Predict Local Relapses In Early Stage Urinary Bladder Cancer. European Journal
Of Cancer, Vol. 34(6); P. 934-936, Issn: 0959-8049, Doi: 10.1016/S0959-8049(97)10118-6
Gazzaniga P, Vercillo R, Gradilone A, Silvestri I, Gandini O., Napolitano M, Giuliani L, Fioravanti
A, Gallucci M, A. Agliano' (1998). Prevalence Of Papillomavirus, Epstein-Barr Virus,
Cytomegalovirus And Herpes Simplex Virus Type 2 In Urinary Bladder Cancer. Journal Of Medical
Virology, Vol. 55 (4); P. 262-267, Issn: 0146-6615, Doi: 10.1002/(Sici)1096-9071(199808)55
Gandini O., Kohno H, Curtis S, Korach Ks (1997). Two Transcription Activation Functions In The
Amino Terminus Of The Mouse Estrogen Receptor That Are Affected By The Carboxy Terminus.
Steroids, Vol. 62; P. 508-515, Issn: 0039-128x
Agliano' Am, Naso G, Silvestri I, Gradilone A, Vercillo R, Napolitano M, Gazzaniga P, Gandini O.,
Realacci M, Santangelo C, Saccani G, Manzari V, Frati L (1997). Involvment Of Bcl-2 And Bax
Gene Expression In Apoptosis And Differentiation Of The Non-Tumorigenic Murine Hematopoietic
Cell Line, 32dcl3(G). International Journal Of Oncology, Vol. 11; P. 1271-1277, Issn: 1019-6439
Gazzaniga P, Gradilone A, Vercillo R, Gandini O., Silvestri I, Napolitano M, Albonici L, Vincenzoni
A, Gallucci M, Frati L, Agliano Am (1996). Bcl-2/Bax Mrna Expression Ratio As Prognostic Factor
In Low-Grade Urinary Bladder Cancer. International Journal Of Cancer, Vol. 69; P. 100-104, Issn:
0020-7136, Doi: 10.1002/(Sici)1097-0215(19960422)69:2<100::Aid-Ijc5>3.0.Co;2-4
Kohno H, Bocchinfuso Wp, Gandini O., Curtis Sw, Korach Ks (1996). Mutational Analysis Of The
Estrogen Receptor Ligand-Binding Domain: Influence Of Ligand Structure And Stereochemistry On
Transactivation. Journal Of Molecular Endocrinology, Vol. 16; P. 277-285, Issn: 0952-5041
Gradilone A, Vercillo R, Napolitano M, Cardinali G, Gazzaniga P, Silvestri I, Gandini O., Tomao S,
Aglianò Am. (1996). Prevalence Of Human Papillomavirus, Cytomegalovirus, And Epstein-Barr
Virus In The Cervix Of Healthy Women. Journal Of Medical Virology, Vol. 50; P. 1-4, Issn: 01466615, Doi: 10.1002/(Sici)1096-9071(199609)50:1<1::Aid-Jmv1>3.0.Co;2-5
Gazzaniga P, Gradilone A, Vercillo R, Gandini O., Silvestri I, Napolitano M, Albonici L, Vincenzoni
A, Gallucci M, Frati L, Agliano Am (1996). Bcl-2/Bax Mrna Expression Ratio As Prognostic Factor
In Low-Grade Urinary Bladder Cancer. International Journal Of Cancer, Vol. 69; P. 100-104, Issn:
0020-7136, Doi: 10.1002/(Sici)1097-0215(19960422)69:2<100::Aid-Ijc5>3.0.Co;2-4
A. Gradilone, C. Greco, P. Gazzaniga, R. Vercillo, M. Napolitano, Gandini O., F. Mattei, L. Frati, A.
M. Agliano (1996). Bax Gene Expression In Melanoma Metastases. Journal Of Investigative
Dermatology, Vol. 106; P. 382-382, Issn: 0022-202x, Doi: 10.1111/1523-1747.Ep12343191
Gandini O., Kohno H, P. Gazzaniga, Korach K (1995). Alteration Of Transcriptional Activity Of The
Mouse Estrogen Receptor By N-Terminal Deletions And C-Terminal Point Mutations. In: De Bellis
A. And Schipani E. "Future Trends In Endocrinology". Vol. 1, De Bellis A. And Schipani E,
Isbn/Issn: 9788885974432
Gazzaniga P, Gallucci M, Gradilone A, Gandini O., Vincenzoni A, Gianni W, Naso G, Frati L,
Agliano Am (1995). Detection Of Bcl-2 Rna In Low Grade Tumours Of The Urinary Bladder.
European Journal Of Cancer, Vol. 31a; P. 2119-2120, Issn: 0959-8049, Doi: 10.1016/09598049(95)00404-1
Kohno H, Gandini O., Curtis Sw, Korach Ks (1994). Anti-Estrogen Activity In The Yeast
Transcription System: Estrogen Receptor Mediated Agonist Response. Steroids, Vol. 59; P. 572-578,
Issn: 0039-128x
Aglianò Am, Vania A, Gandini O., Gradilone A, Napolitano M, Albonici L, Falconieri P, Digilio G,
Manzari V, Frati L (1992). Post-Transfusional Human Retrovirus Infection In 41 Italian BetaThalassemic Patients. Haematologica, Vol. 77; P. 54-59, Issn: 0390-6078
Vacca A, Fazio Vm, Gandini O., Oppido P, Delfini R, Frati L, Gulino A (1989). Altered Restriction
Pattern Of The Putative Dna Binding Domain Of Estrogen Receptor Or Related Genes In Primary
Human Meningiomas. International Journal Of Cancer, Vol. 43(4); P. 567-569, Issn: 0020-7136,
Doi: 10.1002/Ijc.2910430406
LIBRI
1) Gandini O., Kohno H., Gazzaniga P., Korach K.
Alteration of Transcriptional Activity of the mouse Estrogen Receptor by N-terminal deletions and
C-terminal point mutations. In "FUTURE TRENDS IN ENDOCRINOLOGY".
De Bellis A. and Schipani E. eds,1995.