CURRICULUM VITAE Massimo Zuin Luogo e data di nascita
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CURRICULUM VITAE Massimo Zuin Luogo e data di nascita
Massimo Zuin, Curriculum vitae CURRICULUM VITAE Massimo Zuin Luogo e data di nascita: Noventa Padovana (PD); 7 Agosto 1950 Attuale posizione accademica: - Professore Associato di Medicina Interna (MED09) – Università degli Studi di Milano – Dipartimento di Scienze della Salute. - Direttore Unità Operativa Complessa di Medicina, Epatologia e Gastroenterologia – Az.Osp San Paolo Polo Universtario, via A. di Rudinì 8; 20142 Milano. - Presidente del Corso di Laurea in Dietistica (Triennio 2014-2017) Recapiti: Tel: +39-02.50323093 Fax: +39-02.50323089 e-mail: [email protected] Curriculum studiorum: 1975: Laurea in Medicina e Chirurgia presso l’Università degli Studi di Milano 1979: Specializzazione in Gastroenterologia presso l’Università di Ferrara 1985: Specializzazione in Medicina Interna presso l’Università degli Studi di Milano Curriculum universitario: 1976-1980: Borsista universitario presso l’Istituto di Clinica Medica III dell’Università degli Studi di Milano 1980-1989: Ricercatore confermato presso l’Istituto di Medicina Interna dell’Università degli Studi di Milano 1989-2000: Ricercatore confermato presso il Dipartimento di Medicina, Chirurgia ed Odontoiatria dell’Università degli Studi di Milano 2001–2006: Direttore della Scuola di Specializzazione Malattie del Fegato e del Ricambio Dal 2001: Professore Associato in Medicina Interna presso il Dipartimento di Medicina, Chirurgia ed Odontoiatria dell’Università degli Studi di Milano Attività assistenziale: 1981-1989: Assistente presso l’Istituto di Clinica Medica III - Ospedale Policlinico di Milano 1990-2001: Aiuto presso la Divisione di Medicina Generale – Clinica Medica del Dipartimento di Medicina dell’ A.O San Paolo 2002–2003: Vicedirettore dell’U.O Medicina III - Clinica Medica del Dipartimento di Medicina dell’A.O San Paolo 1 Massimo Zuin, Curriculum vitae 2004-2009: Direttore dell’ Unità Dipartimentale di Epatologia e Gastroenterologia Medica del Dipartimento di Medicina dell’ A.O San Paolo Dal 2009: Direttore dell’U.O di Medicina VI-Epatologia e Gastroenterologia del Dipartimento di Medicina dell’ A.O San Paolo Attività Scientifica: - Epidemiologia e trattamento medico della colelitiasi - Conseguenze epatiche ed extra-epatiche delle alterazioni del circolo entero-epatico degli acidi biliari - Immunogenetica della Cirrosi Biliare Primitiva e della Colangite Sclerosante Primitiva - Fattori di rischio cardiovascolare nelle epatopatie croniche colestatiche - Terapia delle malattie croniche colestatiche - Efficacia e sicurezza del trattamento antivirale nella epatite cronica HCV-correlata - Stadiazione e trattamento dell’epatocarcinoma - Epidemiologia delle epatopatie metaboliche e dei fattori di rischio cardiovascolare in eta’ pediatrica e adulta Partecipazione scientifica nell’ambito di programmi di ricerca di interesse nazionale 1984-1995: Responsabile di Unità Operativa nell’ambito dello Studio “Multicentrica Italiana COLelitiasi” (M.I.COL.) coordinato dall’Istituto Superiore di Sanità e inserito nel Progetti Finalizzati C.N.R. “Medicina Preventiva e Riabilitativa” (1982-1987) e “Prevenzione e Controllo dei Fattori di Rischio” (1990-1995) 1998-2000: Partecipazione al Programma di Ricerca Scientifica di rilevante interesse nazionale del Ministero dell’Università e della Ricerca Scientifica e Tecnologica (M.U.R.S.T. #9806210866) (ex 40%) “La colestasi nell'uomo e in modelli sperimentali. Biologia cellulare e molecolare della secrezione biliare e delle sue alterazioni come causa di danno epatico e progressione di malattia” (coordinatore Prof. L. Okolicsanyi) 1999-2001: Responsabile di Unità Operativa nell’ambito del Programma di Ricerca Scientifica di rilevante interesse nazionale del Ministero dell’Università e della Ricerca Scientifica e Tecnologica (M.U.R.S.T.) (ex 40%) “Difetti congeniti ed acquisiti del catabolismo del colesterolo: importanza relativa delle due vie di sintesi degli acidi biliari” (coordinatore Prof. G. C. Galli) 2002-2004: Responsabile di Unità Operativa nell’ambito del programma di ricerca 2 Massimo Zuin, Curriculum vitae scientifica di rilevante interesse nazionale del Ministero dell’Università e della Ricerca Scientifica e Tecnologica (M.U.R.S.T.) (ex 40%): “Regolazione del catabolismo del colesterolo ad acidi biliari nell’uomo: modelli sperimentali in vivo”. (Coordinatore: A. Federico). 2004-2006: Responsabile di Unità Operativa nell’ambito del programma di ricerca scientifica di rilevante interesse nazionale del Ministero dell’Università e della Ricerca Scientifica e Tecnologica (M.U.R.S.T.) (ex 40%): "Interazioni fra metabolismo lipidico e sintesi degli acidi biliari, con particolare riferimento alla via extraepatica, in pazienti con sindrome metabolica, con colestasi cronica o gravemente obesi. Modelli sperimentali in vivo e in vitro" (coordinatore: Prof. N. Carulli). Partecipazione scientifica nell’ambito di programmi di ricerca di interesse regionale 2008 -2012 Responsabile del: “Progetto CAMELIA: studio di popolazione sulle interazioni tra malattie cardiovascolari, sindrome metabolica, malattie di fegato e autoimmunità”nell’ambito dei progetti innovativi di sviluppo in campo cardio-cerebro vascolare della Regione Lombardia e in collaborazione con l’Istituto Superiore di Sanità. Sintesi della produzione scientifica: Pubblicazioni in extenso su riviste censite secondo impact factor: n 126 Impact Factor (Journal Citation Reports 2013): 807.215 H-index (Scopus):34 3 Massimo Zuin, Curriculum vitae PUBBLICAZIONI IN EXTENSO A. Lavori originali pubblicati in extenso su riviste censite secondo impact factor Impact factor (JCR, 2013) 1976 1. Tritapepe R, Di Padova C, Zuin M, Bellomi M, Podda M. Lithogenic bile after conjugated estrogen. N Eng J Med 1976;295:961-2 (letter). 54.420 1978 2. Di Padova C, Zuin M, Bellomi M, Podda M. Choleretic and anti-choleretic effects of furosemide in the rat. Ital J Gastroenterol 1978;10:92-6. 0.451 3. Di Padova C, Zuin M, Campana G, Podda M. Cholesterol supersaturation of bile in women during oral contraceptive use. Ital J Gastroenterol 1978;10:62-3. 0.451 1979 4. Zuin M, Di Padova C, Rovagnati P, Lasala G, Cammareri G. Cycloxilic acid and the bile lipids in oral contraceptive users. Arzneim-Forsch/Drug Res 1979;29:837-9. 0.507 1980 5. Gianni L, Di Padova F, Zuin M, Podda M. Bile acid-induced inhibition of the lymphoproliferative response to phytohemagglutinin and pokeweed mitogen: an in vitro study. Gastroenterology 1980;78:231-5. 13.926 6. Annoni G, Dioguardi ML, Tripodi A, Zuin M. Enzymic assay of choline-containing phospholipids in bile. Clin Chem 1980;26:669. 7.768 7. Podda M, Zuin M, Dioguardi ML, Festorazzi S, Di Padova C. Effect of Dihyroxydibutylether (DHBE) on bile flow and composition in rats with ethynilestradiol-induced cholestasis. Arzneim-Forsch/Drug Res 1980;30:2126-8. 0.507 8. Carulli N, Ponz De Leon M, Podda M, Zuin M, Strata A, Frigerio G, Digrisolo A. Chenodeoxycholic acid and ursodeoxycholic acid effects in endogenous hypertriglyceridemias. A controlled double-blind trial. J Clin Pharmacol 1981;21:436-42. 2.472 9. Podda M, Zuin M, Carulli N, Ponz De Leon M, Dioguardi ML. Gallstone dissolution after 6 months of ursodeoxycholic acid (UDCA): effectiveness of different doses. J Int Med Res 1982;10:59-63. 1.095 10. Podda M, Zuin M, Dioguardi ML, Festorazzi S. Successful treatment of gallstones with bile acids in obese adolescents. Arch Dis Child 1982;57:956-8. 3.861 11. Podda M, Zuin M, Dioguardi ML, Festorazzi S, Dioguardi N. A combination of chenodeoxycholic and ursodeoxycholic acid is more effective than either alone in reducing biliary cholesterol saturation. Hepatology 1982;2:334-9. 11.190 4 Massimo Zuin, Curriculum vitae 1983 12. Carulli N, Ponz De Leon M, Podda M, Di Padova C, Zuin M. Effect of cicloxilic acid on bile lipid composition in patients with gallstones: a multicenter trial. Digestion 1983;28:102-7. 2.032 1984 13. Vergani CG, Plancher AC, Zuin M, Cattaneo M, Tramaloni C, Maccari S, Roma P, Catapano AL. Bile lipid composition and haemostatic variables in case of high density lipoprotein deficiency (Tangier disease). Eur J Clin Invest 1984;14:49-54. 2.834 1985 14. Podda M, Zuin M. Effects of fenofibrate on biliary lipids and bile acid pool size in patients with type IV hyperlipoproteinemia. Atherosclerosis 1985;55:135-42. 3.971 1987 15. Zuin M, Battezzati PM, Camisasca M, Riebenfeld D, Podda M. Effects of ginsenosides against hepatotoxin-induced chronic liver disease in the elderly. J Int Med Res 1987;15:276-81. 1.095 16. Masci E, Testoni PA, Fanti L, Guslandi M, Zuin M, Tittobello A. Duodenogastric reflux: correlations among bile acid pattern, mucus secretion and mucosal damage. Scand J Gastroenterol 1987;22:308-12. 2.329 1988 17. Podda M, Ghezzi C, Battezzati PM, Bertolini E, Crosignani A, Petroni ML, Zuin M. Ursodeoxycholic acid for chronic liver disease. J Clin Gastroenterol 1988;10:25-31. 3.186 1989 18. Podda M, Ghezzi C, Battezzati PM, Bertolini E, Crosignani A, Petroni ML, Zuin M. Effect of different doses of ursodeoxycholic acid in chronic liver disease. Dig Dis Sci 1989;34:59-65. 2.550 19. Podda M, Zuin M, Battezzati PM, Ghezzi C, De Fazio C, Dioguardi ML. Efficacy and safety of a combination of chenodeoxycholic acid and ursodeoxycholic acid for gallstone dissolution: a comparison with ursodeoxycholic acid alone. Gastroenterology 1989;96:222-9. 13.926 1990 20. Podda M, Ghezzi C, Battezzati PM, Crosignani A, Zuin M, Roda A. Effect of ursodeoxycholic acid and taurine on serum liver enzymes and bile acids in chronic hepatitis. Gastroenterology 1990;98:1044-50. 13.926 1991 21. Zuin M, Petroni ML, Grandinetti G, Crosignani A, Bertolini E, Battezzati PM, Podda M. Comparison of effects of chenodeoxycholic and ursodeoxycholic acid and their combination on biliary lipids in obese patients with gallstones. Scand J Gastroenterol 1991;26:257-62. 2.329 22. Crosignani A, Battezzati PM, Setchell KDR, Camisasca M, Bertolini E, Roda A, Zuin M, Podda M. Effects of ursodeoxycholic acid on serum liver enzymes and bile acid metabolism in chronic active hepatitis: a dose-response study. Hepatology 1991;13:339-44. 11.190 5 Massimo Zuin, Curriculum vitae 23. Bertolini E, Zermiani P, Battezzati PM, Bruno S, Villa E, Manenti F, Marelli F, Moroni GA, Zuin M, Podda M. Lack of association between circulating HCV-RNA and anti-HCV positivity in primary biliary cirrhosis. Lancet 1991;337:675-6 (letter). 39.207 24. Crosignani A, Podda M, Bertolini E, Battezzati PM, Zuin M, Setchell KDR. Failure of ursodeoxycholic acid to prevent a cholestatic episode in a patient with benign recurrent intrahepatic cholestasis: a study of bile acid metabolism. Hepatology 1991;13:1076-83. 11.190 25. Crosignani A, Podda M, Battezzati PM, Bertolini E, Zuin M, Watson D, Setchell KDR. Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 1991;14:1000-7. 11.190 26. Bertolini E, Battezzati PM, Zermiani P, Bruno S, Moroni GA, Marelli F, Villa E, Manenti F, Zuin M, Crosignani A, Podda M. Hepatitis virus C testing in primary biliary cirrhosis. J Hepatol 1992;15:207-10. 10.401 27. Bertolini E, Marelli F, Zermiani P, Battezzati PM, Zuin M, Moroni GA, Podda M. Antibodies to hepatitis C virus in primary biliary cirrhosis. Arch Virol 1992;54:205-9. 2.282 28. Battezzati PM, Podda M, Bruno S, Zuin M, Crosignani A, Camisasca M, Chiesa A, Petroni ML, Russo A, Gallotti P, Borzio M, Buscarini L, Fornari F, Sbolli G, Lanzini A, Pigozzi MG, Salmi A, Dastoli G, Carriero PL. Factors predicting early response to treatment with recombinant interferon alpha-2a in chronic nonA-non B hepatitis. Preliminary report of a longterm trial. Ital J Gastroenterol 1992;24:481-4. 0.451 1993 29. Bellentani S, Podda M, Tiribelli C, Callea F, Marazzi M, Sodde M, Merlini R, Battezzati PM, Crosignani A, Zuin M, Manenti F. Ursodiol in the long-term treatment of chronic hepatitis: a double-blind multicenter clinical trial. J Hepatol 1993;19:459-64. 10.401 1994 30. Camisasca M, Crosigani A, Battezzati PM, Albisetti W, Grandinetti G, Pietrogrande L, Biffi A, Zuin M, Podda M. Parenteral calcitonin for metabolic bone disease associated with primary biliary cirrhosis. Hepatology 1994;20:633-7. 11.190 31. Pulvirenti A, Regalia E, Bianchi E, Zuin M, Gennari L, Baratti D, Mazzaferro V. Successful liver transplantation from a donor with chromosomal abnormality (45,X0). Tranplant Proc 1994;26:3655-6. 0.952 32. Lesma A, Gobbi G, Zuin M, Callioni F, Rovati V. Laparoscopic cholecystectomy using methyl tert-butil ether: preliminary results. Surgical Laparoscopy Endoscopy 1994;4:13-7. 0.938 1992 6 Massimo Zuin, Curriculum vitae 33. Guan Lim A, Jazrawi RP, Ahmed HA, Levy JH, Zuin M, Douds AC, Maxwell JD, Northfield TC. Soluble intercellular adhesive molecule-1 in primary biliary cirrhosis: relationship with disease stage, immune activity and cholestasis. Hepatology 1994;882-8. 11.190 34. Bruno S, Rossi S, Petroni ML, Villa E, Zuin M, Podda M. Normal aminotransferase concentrations in patients with antibodies to hepatitis C virus. Br Med J 1994;308:697. 16.378 1995 35. Torgano G, Vecchi M, Podda M, Zuin M, Arosio E, Battezzati PM, De Franchis R. Primary biliary cirrhosis is associated with specific changes in liver IgGbearing cell subpopulations. J Hepatol 1995;22:1-6. 10.401 1996 36. Crosignani A, Battezzati PM, Setchell KDR, Invernizzi P, Covini G, Zuin M, Podda M. Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. A dose-response study. Dig Dis Sci 1996;41:809-15. 2.550 37. Petroni ML, Jazrawi RP, Lanzini A, Zuin M, Pazzi P, Fracchia M, Boga E, Facchinetti D, Alvisi V, Galatola G, Bland JM, Heaton KW, Podda M, Northfield TC. Repeated bile acid therapy for the long-term management of cholesterol gallstones. J Hepatol 1996;25:719-24. 10.401 38. Podda M, Crosignani A, Battezzati PM, Quagliuolo M, Valsania C, Invernizzi P, Zuin M. Ursodeoxycholic acid therapy in primary biliary cirrhosis. Ital J Gastroenterol 1996;28:114-7. 0.451 39. Invernizzi P, Crosignani A, Battezzati PM, Covini G, De Valle G, Larghi A, Zuin M, Podda M. Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and –negative primary biliary cirrhosis. Hepatology 1997;25:1090-5. 11.190 40. Larghi A, Crosignani A, Battezzati PM, De Valle G, Allocca M, Invernizzi P, Zuin M, Podda M. Ursodeoxycholic and tauro-ursodeoxycholic acids for the treatment of primary biliary cirrhosis: a pilot crossover study. Aliment Pharmacol Ther 1997;11:409-14. 5.478 41. Bardella MT, Quatrini M, Zuin M, Podda M, Cesarini L, Velio P, Bianchi P, Conte D. Screening patients with celiac disease for primary biliary cirrhosis and vice versa. Am J Gastroenterol 1997;92:1524-6. 9.213 42. Mazzaferro V, Regalia E, Pulvirenti A, Tagger A, Andreola S, Pasquali M, Baratti D, Romano F, Palazzo U, Zuin M, Bonino F. Prophylaxis against HCV recurrence after liver transplantation: effect of interferon and ribavirin composition. Transplant Proc 1997;29:519-21. 0.952 1997 7 Massimo Zuin, Curriculum vitae 1998 43. Larghi A, Tagger A, Crosignani A,. Ribero ML, Bruno S, Portera G, Battezzati PM, Maggioni M, Fasola M, Zuin M, Podda M. Clinical significance of hepatic HCV-RNA in patients with chronic hepatitis C demonstrating long-term sustained response to interferon-alpha therapy. J Med Virol 1998;55:7-11. 2.217 44. Invernizzi P, Battezzati PM, Crosignani A, Zermiani P, Bignotto M, Del Papa N, Zuin M, Podda M. Antibody to carbonic anhydrase II is present in primary biliary cirrhosis (PBC) irrespective of antimitochondrial antibody status. Clin Exp Immunol 1998;114:448-54. 3.278 1999 45. Tagger A, Ribero ML, Larghi A, Donato F, Zuin M, Chiesa R, Benetti GP, Ramella G, Borzio M, Podda M. Prevalence of GB virus-C/hepatitis G virus infection in patients with cryptogenic chronic liver disease and in patients with primary biliary cirrhosis or Wilson’s disease. Am J Gastroenterol 1999;94:484-8. 9.213 2000 46. Invernizzi P, De Andreis C, Sirchia SM, Battezzati PM, Zuin M., Rossella F, Perego F, Bignotto M, Simoni G, Podda M. Blood fetal microchimerism in primary biliary cirrhosis. Clin Exp Immunol 2000;122:418-22 3.278 47. Zuin M., Podda M, Selmi C, Giorgini A, Zermiani P, Mandelli G, Sacchetta AC, Candiani C. Gastrointestinal tolerability of ibuprofen administered in two pharmaceutical formulations. Arzneimittelforschung 2000;50:837-42 0.507 48. Petroni ML, Jazrawi RP, Pazzi P, Zuin M., Lanzini A, Fracchia M, Facchinetti D, Alvisi V, Ferraris R, Bland JM, Heaton KW, Podda M, Northfield TC. Risk factors for the development of gallstone recurrence following medical dissolution. The British-Italian Gallstone Study Group. Eur J Gastroenterol Hepatol 2000;12:695-700 2.152 49. Battezzati P.M., Zuin M., Crosignani A., Allocca M., Invernizzi P., Selmi C., Villa E., Podda M. Ten-year combination treatment with colchicine and ursodeoxycholic acid for primary billiary cirrhosis: a double-blind, placebo-controlled trial on symptomatic patients. Aliment Pharmacol Ther 2001;15:1427-34 5.478 50. Montorsi M, Santambrogio R, Bianchi P, Opocher E, Cornalba GP, Dapri G, Bonavina L, Zuin M, Podda M. Laparoscopy with laparoscopic ultrasound for pretreatment staging of hepatocellular carcinoma: a prospective study. J Gastrointest Surg 2001;5:312-5 2.391 51. Invernizzi P, Podda M, Battezzati PM, Crosignani A, Zuin M., Hitchman E, Maggioni M, Meroni PL, Penner E, Wesierska-Gadek J. Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis. J Hepatol 2001;34:366-72 10.401 2001 8 Massimo Zuin, Curriculum vitae 2002 2003 52. Montorsi M, Santambrogio R, Bianchi P, Opocher E, Zuin M., Bertolini E, Bruno S, Podda M. Radiofrequency interstitial thermal ablation of hepatocellular carcinoma in liver cirrhosis. Role of the laparoscopic approach. Surg Endosc 2001;15:141-5 3.313 53. Montorsi M, Santambrogio R, Bianchi P, Opocher E, Tagliaferri B, Zuin M., Bertolini E, Podda M. Laparoscopic radiofrequency of hepatocellular carcinoma (HCC) in liver cirrhosis. Hepatogastroenterology 2001;48:41-5 0.907 54. Del Puppo M, Galli Kienle M, Crosignani A, Petroni ML, Amati B, Zuin M., Podda M. Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. J Lipid Res 2001;42:437-41 4.730 55. Petroni ML, Jazrawi RP, Pazzi P, Lanzini A, Zuin M., Pigozzi MG, Fracchia M, Galatola G, Alvisi V, Heaton KW, Podda M, Northfield TC. Ursodeoxycholic acid alone or with chenodeoxycholic acid for dissolution of cholesterol gallstones: a randomized multicentre trial. The British-Italian Gallstone Study group. Aliment Pharmacol Ther 2001;15:123-8 5.478 56. Melero S, Spirli C, Zsembery A, Medina JF, Joplin RE, Duner E, Zuin M., Neuberger JM, Prieto J, Strazzabosco M. Defective regulation of cholangiocyte Cl-/HCO3(-) and Na+/H+ exchanger activities in primary biliary cirrhosis. Hepatology 2002;35:1513-21 11.190 57. Longo M, Crosignani A, Battezzati PM, Squarcia Giussani C, Invernizzi P, Zuin M., Podda M. Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis. Gut 2002;51:265-9 13.319 58. Larghi A, Zuin M., Crosignani A, Ribero ML, Pipia C, Battezzati PM, Binelli G, Donato F, Zanetti AR, Podda M, Tagger A. Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies. Hepatology 2002;36:993-1000 11.190 59. Selmi C., Zuin M., Biondi M.L., Invernizzi P., Battezzati P.M., Bernini M., Meda F., Gershwin M.E., Podda M. Genetic variants of the endothelial nitric oxide synthase in patients with primary biliary cirrhosis: Association with disease severity. J Gastroenterol Hepatol 2003;18:1150-5 3.627 60. Invernizzi P, Battezzati PM, Crosignani A, Perego F, Poli F, Morabito A, De Arias AE, Scalamogna M, Zuin M., Podda M. Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis. J Hepatol 2003;38:401-6 10.401 61. Santambrogio R, Podda M, Zuin M., Bertolini E, Bruno S, Cornalba GP, Costa M, Montorsi M. Safety and efficacy of laparoscopic radiofrequency ablation of hepatocellular carcinoma in patients with liver cirrhosis. Surg Endosc 2003;17:1826-32 3.313 9 Massimo Zuin, Curriculum vitae 2005 62. Okolicsanyi L, Groppo M, Floreani A, Morselli-Labate AM, Rusticali AG, Battocchia A, Colombo M, Galatola G, Gasbarrini G, Podda M, Ricci G, Rosina F, Zuin M.. Treatment of primary sclerosing cholangitis with low-dose ursodeoxycholic acid: results of a retrospective Italian multicentre survey. Dig Liver Dis 2003;35:325-31 2.889 63. Neri TM, Cavestro GM, Seghini P, Zanelli PF, Zanetti A, Savi M, Podda M, Zuin M., Colombo M, Floreani A, Rosina F, Bianchi Porro G, Strazzabosco M, Okolicsanyi L. Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. Dig Liver Dis 2003;35:571-6 2.889 64. Abu-Mouch S, Selmi C, Benson GD, Kenny TP, Invernizzi P, Zuin M., Podda M, Rossaro L, Gershwin ME. Geographic clusters of primary biliary cirrhosis. Clin Dev Immunol 2003;10:127-31 2.934 65. Busatto P., Blasi F., Casanova F., Selmi C., Centanni S., Zuin M. Lack of PBC-specific antimitochondrial antibodies in patients with Chlamydia pneumoniae infection (research letter). J Gastroenterol Hepatol 2005;20:1626-7 3.627 66. Del Puppo M, Crosignani A, Longo M, Zuin M., Podda M, Galli G, De Fabiani E, Ciuffreda P, Santaniello E, Javitt NB, Kienle MG. A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. Clin Chim Acta 2005;355:23-31 2.764 67. Giorgini A., Selmi C., Invernizzi P., Podda M., Zuin M., Gershwin M.E. Primary biliary cirrhosis: an overview. Ann NY Acad Sci 2005;1051:185-93 4.313 68. Selmi C., Zuin M., Gershwin M.E. The bile duct cell: a bully or a victim? Liver Transpl 2005;11:878-80 3.793 69. Invernizzi P., Miozzo M., Selmi C., Persani L., Battezzati P.M., Zuin M., Lucchi S., Meroni P.L., Marasini B., Zeni S., Watnik M., Grati F., Simoni G., Gershwin M.E., Podda M. X chromosome monosomy: a common mechanism for autoimmune diseases. J Immunol 2005;175:575-8 5.362 70. Selmi C., Invernizzi P., Zuin M., Podda M., Gershwin M.E. Genetics and geoepidemiology of primary biliary cirrhosis: following the footprints to disease etiology. Semin Liver Dis 2005;25:265-80 71. Selmi C., Invernizzi P., Zuin M., Podda M., Seldin M.F., Gershwin M.E. Genes and (auto)immunity in primary biliary cirrhosis. Genes Immun 2005;6:543-56 5.123 72. Invernizzi P, Selmi C., Zuin M., Podda M. Lack of serum antibodies to membrane-bound carbonic anhydrase IV in primary biliary cirrhosis. Gut 2005;54:1665 13.319 10 3.789 Massimo Zuin, Curriculum vitae 2006 2007 2008 73. Wesierska-Gadek J., Penner E., Battezzati P.M., Selmi C., Zuin M., Hitchman E., Worman H.J., Gershwin M.E., Podda M., Invernizzi P. Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis. Hepatology 2006;43:1135-1144 11.190 74. Allocca M., Crosignani A., Gritti A., Ghilardi A. , Gobatti D., Caruso D., Zuin M. , Podda M., Battezzati P.M Hypercholesterolaemia is not associated with early atherosclerotic lesions in primary biliary cirrhosis Gut 2006 ;55: 1795-800 13.319 75. Allocca M, Crosignani A, Gritti A, Benetti A, Zuin M, Podda M, Battezzati PM. Inadequate dietary intake but not renal tubular acidosis is associated with bone demineralization in primary biliary cirrhosis. Aliment Pharmacol Ther. 2007 Jan 15;25(2):219-27 5.478 76. Crosignani A, Del Puppo M, Longo M, De Fabiani E, Caruso D, Zuin M, Podda M, Javitt NB, Kienle MG. Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. Clin Chim Acta. 2007 Jul;382(1-2):82-8. Epub 2007 Apr 12. 2.764 77. Miozzo M, Selmi C, Gentilin B, Grati FR, Sirchia S, Oertelt S, Zuin M, Gershwin ME, Podda M, Invernizzi P. Preferential X chromosome loss but random inactivation characterize primary biliary cirrhosis. Hepatology. 2007 Aug;46(2):456-62. 11.190 78. Invernizzi P, Miozzo M, Oertelt-Prigione S, Meroni PL, Persani L, Selmi C, Battezzati PM, Zuin M, Lucchi S, Marasini B, Zeni S, Watnik M, Tabano S, Maitz S, Pasini S, Gershwin ME, Podda M X monosomy in female systemic lupus erythematosus. Ann N Y Acad Sci. 2007 Sep;1110:84-91. 4.313 79. Serum autoantibodies: a road map for the clinical hepatologist. Meda F, Zuin M, Invernizzi P, Vergani D, Selmi C. Autoimmunity. 2008 Feb;41(1):27-34. 2.754 80. Benetti A, Crosignani A, Varenna M, Giussani CS, Allocca M, Zuin M, Podda M, Battezzati PM Primary biliary cirrhosis is not an additional risk factor for bone loss in women receiving regular calcium and vitamin D supplementation: a controlled longitudinal study. J Clin Gastroenterol. 2008 Mar;42(3):306-11. 3.186 81. Selmi C, Zuin M, Bowlus CL, Gershwin ME. Anti-mitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis. 2008 Feb;12(1):173-85, ix. doi: 10.1016/j.cld.2007.11.008. Review. 3.820 82. Zuin M, Giorgini A, Selmi C, Battezzati PM, Cocchi CA, Crosignani A, Benetti A, Invernizzi P, Podda M Acute liver and renal failure during treatment with buprenorphine at therapeutic dose. Dig Liver Dis. 2009 Jul;41(7):e8-e10. doi: 10.1016/j.dld.2007.12.014. Epub 2008 Feb 21 2.550 11 Massimo Zuin, Curriculum vitae 83. Benetti A, Crosignani A, Varenna M, Giussani CS, Allocca M, Zuin M, Podda M, Battezzati PM Primary biliary cirrhosis is not an additional risk factor for bone loss in women receiving regular calcium and vitamin D supplementation: a controlled longitudinal study. J Clin Gastroenterol. 2008 Mar;42(3):306-11. 3.186 84. Selmi C, Zuin M, Bowlus CL, Gershwin ME Anti-mitochondrial antibodynegative primary biliary cirrhosis. Clin Liver Dis. 2008 Feb;12(1):173-85, 2.703 85. Benetti A, Crosignani A, Varenna M, Giussani CS, Allocca M, Zuin M, Podda M, Battezzati PM. Primary biliary cirrhosis is not an additional risk factor for bone loss in women receiving regular calcium and vitamin D supplementation: a controlled longitudinal study. J Clin Gastroenterol. 2008 Mar;42(3):306-11 3.186 86. Selmi C, Zuin M, Bowlus CL, Gershwin ME. Anti-mitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis. 2008 Feb;12(1):173-85. 2.703 87. Benetti A, Crosignani A, Varenna M, Giussani CS, Allocca M, Zuin M, Podda M, Battezzati PM. Primary biliary cirrhosis is not an additional risk factor for bone loss in women receiving regular calcium and vitamin D supplementation: a controlled longitudinal study. J Clin Gastroenterol. 2008 Mar;42(3):306-11. 3.186 88. Benetti A, Crosignani A, Varenna M, Giussani CS, Allocca M, Zuin M, Podda M, Battezzati PM Primary biliary cirrhosis is not an additional risk factor for bone loss in women receiving regular calcium and vitamin D supplementation: a controlled longitudinal study. J Clin Gastroenterol. 2008 Mar;42(3):306-11. 3.186 89. Selmi C, Zuin M, Bowlus CL, Gershwin ME. Anti-mitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis. 2008 Feb;12(1):173-85. 2.703 90. Selmi C, Diana A, Cocchi CA, Zuin M, Gershwin ME. Environmental factors and the induction of autoimmunity in primary biliary cirrhosis. Expert Rev Clin Immunol. 2008 Mar;4(2):239-45.. 3.342 91. Siegel SM, Selmi C, Dottorini L, Antelmi M, Zuin M, Lanfredini M, Gershwin ME. Late-onset autoimmunity: the paradigm of primary biliary cirrhosis--a minireview. Gerontology. 2008;54(4):193-201. 2.681 92. Selmi C, Zuin M, Gershwin ME The unfinished business of primary biliary cirrhosis. J Hepatol. 2008 Sep;49(3):451-60. 10.401 12 Massimo Zuin, Curriculum vitae 2009 93. Invernizzi P, Selmi C, Poli F, Frison S, Floreani A, Alvaro D, Almasio P, Rosina F, Marzioni M, Fabris L, Muratori L, Qi L, Seldin MF, Gershwin ME, Podda M; Italian PBC Genetic Study Group Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls. Hepatology. 2008 Dec;48(6):1906-12. 11.190 94. Selmi C, Lleo A, Pasini S, Zuin M, Gershwin ME. Innate immunity and primary biliary cirrhosis. Curr Mol Med. 2009 Feb;9(1):45-51. Review. 3.612 95. Zuin M, Giorgini A, Selmi C, Battezzati PM, Cocchi CA, Crosignani Benetti A, Invernizzi P, Podda M. Acute liver and renal failure during treatment with buprenorphine therapeutic dose. Dig Liver Dis. 2009 Jul;41(7):e8-e10 96. Zuin M, Giorgini A, Selmi C, Battezzati PM, Cocchi CA, Crosignani Benetti A, Invernizzi P, Podda M. Acute liver and renal failure during treatment with buprenorphine therapeutic dose. Dig Liver Dis. 2009 Jul;41(7):e8-e10. 2010 2.550 at A, 2.550 at 97. Selmi C, Cocchi CA, Zuin M, Gershwin ME. The chemical pathway to primary biliary cirrhosis. Clin Rev Allergy Immunol. 2009 Feb;36(1):23-9. 4.728 98. Bruno S, Zuin M, Crosignani A, Rossi S, Zadra F, Roffi L, Borzio M, Redaelli A, Chiesa A, Silini EM, Almasio PL, Maisonneuve P Predicting mortality risk in patients with compensated HCV-induced cirrhosis: a long-term prospective study. Am J Gastroenterol. 2009 May;104(5):1147-58. 7 9.213 99. Santambrogio R, Opocher E, Zuin M, Selmi C, Bertolini E, Costa M, Conti M, Montorsi M. Surgical resection versus laparoscopic radiofrequency ablation in patients with hepatocellular carcinoma and Child-Pugh class a liver cirrhosis.Ann Surg Oncol. 2009 Dec;16(12):3289-98. 2.136 100. Giorgini A, Capsoni F, Podda M, Lleó A, Battezzati PM, Ongari AM, Selmi C, Benetti A, Malinverno F, Rossaro L, Gershwin ME, Zuin M. Treatment with PEG-interferon and ribavirin for chronic hepatitis C increases neutrophil and monocyte chemotaxis. Ann N Y Acad Sci. 2009 Sep;1173:847-57. 4.313 101. Zuin M, Giorgini A, Selmi C, Battezzati PM, Cocchi CA, Crosignani A, Benetti A, Invernizzi P, Podda M. Acute liver and renal failure during treatment with buprenorphine at therapeutic dose. Dig Liver Dis. 2009 Jul;41(7):e8-e10. 2.550 102. Morisco F, Stroffolini T, Medda E, Amoruso DC, Almasio PL, Villa E, Zuin M, Paris B, Stanzione M, Caporaso N; NADIR Study Group. Retrospective, observational, multicentre study on an Italian population affected by chronic hepatitis C who failed to clear HCV-RNA after the combined therapy (PEG-IFN and ribavirin): NADIR study. J Viral Hepat. 2010 Jun;17(6):427-34. 3.307 13 A, Massimo Zuin, Curriculum vitae 2011 103. Montali L, Tanaka A, Riva P, Takahashi H, Cocchi C, Ueno Y, Miglioretti M, Takikawa H, Vecchio L, Frigerio A, Bianchi I, Jorgensen R, Lindor KD, Podda M, Invernizzi P; Italian-Japanese PBC Study Group. A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis. Dig Liver Dis. 2010 Oct;42(10):718-23. 2.550 104. Cerri G, Cocchi CA, Montagna M, Zuin M, Podda M, Cavallari P, Selmi C. Patients with primary biliary cirrhosis do not show post-exercise depression of cortical excitability. Clin Neurophysiol. 2010 Aug;121(8):1321-8. 2.979 105. Caserta CA, Pendino GM, Amante A, Vacalebre C, Fiorillo MT, Surace P, Messineo A, Surace M, Alicante S, Cotichini R, Zuin M, Rosmini F, Mele A, Marcucci F. Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy. Am J Epidemiol. 2010 Jun 1;171(11):1195-202. 4.975 106. Oertelt-Prigione S, Crosignani A, Gallieni M, Vassallo E, Podda M, Zuin M. Severe hepatic encephalopathy in a patient with liver cirrhosis after administration of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker combination therapy: a case report. J Med Case Rep. 2010 May 19;4:141. 0.400 107. Caserta CA, Pendino GM, Alicante S, Amante A, Amato F, Fiorillo M, Messineo A, Polito I, Surace M, Surace P, Vacalebre C, Zuin M, Cotichini R, Marcucci F, Rosmini F, Mele A; MAREA Study Group. Body mass index, cardiovascular risk factors, and carotid intima-media thickness in a pediatric population in southern Italy. J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):216-20. 2.873 108. Liu X, Invernizzi P, Lu Y, Kosoy R, Lu Y, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupoli S, Shigeta R, Ransom M, Lleo A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, Rosina F, Borghesio E, Floreani A, Lazzari R, Niro G, Andriulli A, Muratori L, Muratori P, Almasio PL, Andreone P, Margotti M, Brunetto M, Coco B, Alvaro D, Bragazzi MC, Marra F, Pisano A, Rigamonti C, Colombo M, Marzioni M, Benedetti A, Fabris L, Strazzabosco M, Portincasa P, Palmieri VO, Tiribelli C, Croce L, Bruno S, Rossi S, Vinci M, Prisco C, Mattalia A, Toniutto P, Picciotto A, Galli A, Ferrari C, Colombo S, Casella G, Morini L, Caporaso N, Colli A, Spinzi G, Montanari R, Gregersen PK, Heathcote EJ, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, Seldin MF. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nat Genet. 2010 Aug;42(8):658-60. 29.648 109. Santambrogio R, Costa M, Strada D, Bertolini E, Zuin M, Barabino M, Opocher E. Intraoperative ultrasound score to predict recurrent hepatocellular carcinoma after radical treatments. Ultrasound Med Biol. 2011 Jan;37(1):7-15. 2.099 14 Massimo Zuin, Curriculum vitae 2012 2013 110. Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, Poordad F, Goodman ZD, Sings HL, Boparai N, Burroughs M, Brass CA, Albrecht JK, Esteban R; HCV RESPOND-2 Investigators. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med. 2011 Mar 31;364(13):1207-17. 54.420 111. Crosignani A, Zuin M, Allocca M, Del Puppo M. Oxysterols in bile acid metabolism. Clin Chim Acta. 2011 Nov 20;412(23-24):2037-45 2.764 112. Santambrogio R, Costa M, Barabino M, Zuin M, Bertolini E, De Filippi F, Bruno S, Opocher E. Recurrent hepatocellular carcinoma successfully treated with laparoscopic thermal ablation. Surg Endosc. 2012 Apr;26(4):1108-15 3.313 113. Santambrogio R, Opocher E, Costa M, Barabino M, Zuin M, Bertolini E, De Filippi F, Bruno S. Hepatic resection for "BCLC stage A" hepatocellular carcinoma. The prognostic role of alpha-fetoprotein. Ann Surg Oncol. 2012 Feb;19(2):426-34. 3.943 114. Invernizzi P, Ransom M, Raychaudhuri S, Kosoy R, Lleo A, Shigeta R, Franke A, Bossa F, Amos CI, Gregersen PK, Siminovitch KA, Cusi D, de Bakker PI, Podda M, Gershwin ME, Seldin MF; Italian PBC Genetics Study Group. Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis. Genes Immun. 2012 Sep;13(6):461-8. 3.789 115. Poordad F, Bronowicki JP, Gordon SC, Zeuzem S, Jacobson IM, Sulkowski MS, Poynard T, Morgan TR, Molony C, Pedicone LD, Sings HL, Burroughs MH, Sniukiene V, Boparai N, Goteti VS, Brass CA, Albrecht JK, Bacon BR; SPRINT-2 and RESPOND-2 Investigators. Factors that predict response of patients with hepatitis C virus infection to boceprevir. Gastroenterology. 2012 Sep;143(3):608-18.e1-5. 13.926 116. Juran BD, Hirschfield GM, Invernizzi P, Atkinson EJ, Li Y, Xie G, Kosoy R, Ransom M, Sun Y, Bianchi I, Schlicht EM, Lleo A, Coltescu C, Bernuzzi F, Podda M, Lammert C, Shigeta R, Chan LL, Balschun T, Marconi M, Cusi D, Heathcote EJ, Mason AL, Myers RP, Milkiewicz P, Odin JA, Luketic VA, Bacon BR, Bodenheimer HC Jr, Liakina V, Vincent C, Levy C, Franke A, Gregersen PK, Bossa F, Gershwin ME, deAndrade M, Amos CI; Italian PBC Genetics Study Group, Lazaridis KN, Seldin MF, Siminovitch KA Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. Hum Mol Genet. 2012 Dec 1;21(23):5209-21. 6.677 117. Kar SP, Seldin MF, Chen W, Lu E, Hirschfield GM, Invernizzi P, Heathcote J, Cusi D; Italian PBC Genetics Study Group, Gershwin ME, Siminovitch KA, Amos CI. Pathway-based analysis of primary biliary cirrhosis genome-wide association studies. Genes Immun. 2013 Apr;14(3):179-86 3.789 15 Massimo Zuin, Curriculum vitae 2014 2015 118. Demartini B, Camisasca M, Zuin M, Gambini O. A case of isoniazid-induced delirium. J Neuropsychiatry Clin Neurosci. 2013 Spring;25(2):E68-9. 2.765 119. Poordad F, Lawitz E, Reddy KR, Afdhal NH, Hézode C, Zeuzem S, Lee SS, Calleja JL, Brown RS Jr, Craxi A, Wedemeyer H, Nyberg L, Nelson DR, Rossaro L, Balart L, Morgan TR, Bacon BR, Flamm SL, Kowdley KV, Deng W, Koury KJ, Pedicone LD, Dutko FJ, Burroughs MH, Alves K, Wahl J, Brass CA, Albrecht JK, Sulkowski MS; Protocol 6086 Investigators. Effects of ribavirin dose reduction vs erythropoietin for boceprevir-related anemia in patients with chronic hepatitis C virus genotype 1 infection--a randomized trial. Gastroenterology. 2013 Nov;145(5):1035-1044.e5. 13.926 120. Ceresara G, Fogagnolo P, Zuin M, Zatelli S, Bovet J, Rossetti L. Study of corneal copper deposits in Wilson's disease by in vivo confocal microscopy. Ophthalmologica. 2014;231(3):147-52. 1.867 121. Invernizzi P, Bernuzzi F, Lleo A, Pozzoli V, Bignotto M, Zermiani P, Crosignani A, Battezzati PM, Zuin M, Podda M, Raggi C. Telomere dysfunction in peripheral blood mononuclear cells from patients with primary biliary cirrhosis. Dig Liver Dis. 2014 Apr;46(4):363-8. 2.550 122. Pulixi EA, Tobaldini E, Battezzati PM, D'Ingianna P, Borroni V, Fracanzani AL, Maggioni M, Pelusi S, Bulgheroni M, Zuin M, Fargion S, Montano N, Valenti L. Risk of obstructive sleep apnea with daytime sleepiness is associated with liver damage in non-morbidly obese patients with nonalcoholic fatty liver disease. PLoS One. 2014 Apr 24;9(4):e96349. 3.534 123. Mangia A, Cenderello G, Orlandini A, Piazzolla V, Picciotto A, Zuin M, Ciancio A, Brancaccio G, Forte P, Carretta V, Zignego AL, Minerva N, Brindicci G, Marignani M, Baroni GS, Bertino G, Cuccorese G, Mottola L, Ripoli M, Pirisi M. Individualized treatment of genotype 1 naïve patients: an Italian multicenter field practice experience. PLoS One. 2014 Oct 23;9(10):e110284. 3.534 124. Franzini M, Lorenzoni V, Masotti S, Prontera C, Chiappino D, Latta DD, Daves M, Deluggi I, Zuin M, Ferrigno L, Mele A, Marcucci F, Caserta CA, Surace P, Messineo A, Turchetti G, Passino C, Emdin M, Clerico A. The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: a multicenter study in Italy. Clin Chim Acta. 2015 Jan 1;438:376-81 2.764 125. Bruno S, Bollani S, Zignego AL, Pascasio JM, Magni C, Ciancio A, Caremani M, Mangia A, Marenco S, Piovesan S, Chemello L, Babudieri S, Moretti A, Gea F, Colletta C, Perez-Alvarez R, Forns X, Larrubia JR, Arenas J, Crespo J, Calvaruso V, Ceccherini Silberstein F, Maisonneuve P, Craxì A, Calleja JL; Italian and Spanish (IAS)-BoC Study Group. Undetectable HCV-RNA at treatment-week 8 results in high-sustained virological response in HCV G1 treatment-experienced patients with advanced liver disease: the International Italian/Spanish Boceprevir/Peginterferon/Ribavirin Name Patients Program. J Viral Hepat. 2015 May;22(5):469-80. 3.307 16 Massimo Zuin, Curriculum vitae 126. Mottola L, Cenderello G, Piazzolla VA, Forte P, Carretta V, Mecenate F, Brancaccio G, Minisini R, Zuin M, Terreni N, Monti M, Colombo AE, Nosotti L, Minerva N, Luzzitelli I, Kostandini A, Cuccorese G, Russello M, Santoro R, Mangia A. Interleukin-28B genetic variants in untreated Italian HCV-infected patients: a multicentre study. Liver Int. 2015 Feb;35(2):482-8. B. 4.412 Libri di testo, capitoli di libri, lavori pubblicati in extenso su altre riviste 1985 1. M. Podda, P.M. Battezzati, C. Ghezzi, M. Zuin, N. Dioguardi Menopausa e invecchiamento del fegato. In: F. Polvani, T. Nencioni. La prevenzione in menopausa: strategie terapeutiche. Bologna: Monduzzi Editore, 1985, 33-40 1985 2. M. Podda, C. Ghezzi, P.M. Battezzati, M. Zuin Steroidi sessuali femminili e secrezione biliare. In: La Bile: aspetti chimici, farmacologici e fisiopatologici. A. Roda, E. Roda, G. D'Ascenzo, L. Barbara Eds, 1985, 201-5 1985 3. M. Zuin, G. Grandinetti, P.M. Battezzati, C. Ghezzi, M. Podda Metabolismo lipidico e colelitiasi. In: Atti giornata di studio su dismetabolismo lipidico e fegato. CLAS Editoriale, 1985, 5-9 1987 4. M. Podda, M. Zuin, C. De Fazio, M.L. Dioguardi, P.M. Battezzati and C. Ghezzi Comparison of the efficacy and safety of ursodeoxycholic acid alone and in combination with chenodeoxycholic acid in patients with radiolucent gallstones: a randomized controlled trial. In: G. Paumgartner, A. Stiehl, W. Gerok, Eds. Bile acids and the liver. Lancaster: MTP Press Limited, 1987, 347-54 1987 5. M. Podda, M. Zuin, C. Ghezzi, M. Camisasca, P.M. Battezzati Gli acidi biliari in terapia: realtà e prospettive. In: Progressi nella epatologia italiana. Bologna: Editrice Compositori, 1987, 241-9 1987 6. M. Podda, C. Ghezzi, P.M. Battezzati, M. Camisasca, E. Bertolini, M. Zuin Conseguenze della colestasi meccanica di interesse chirurgico. 8th International Congress of Emergency Surgery., V. Staudacher, G.Bevilacqua Ed. Bologna: Monduzzi Editore; 1987, 309-17 1988 7. M. Podda, M. Zuin, P.M. Battezzati Non-surgical treatment of gallstones: cheno-plus ursodeoxycholic acid. In: T.Northfield, R.Jazrawi and P.Zentler-Munro, Eds. Bile Acids in Health and Disease. Dordrecht: Kluwer Academic Publishers, 1988, 187-94 1989 8. M. Podda, P.M. Battezzati, C. Ghezzi, A. Crosignani, E. Bertolini, M. Zuin Ursodeoxycholic acid for chronic liver disease: a dose-response study. In: G. Paumgartner, A. Stiehl, W. Gerok, Eds. Trends in bile acid research. Dordrecht: Kluwer Academic Publishers, 1989, 359-65 17 Massimo Zuin, Curriculum vitae 1990 9. Merisi G. Buongiorno M. Capocaccia R. Mancinelli R. Menotti A. e Gruppo M.I.COL. Risultati di un controllo di qualità per la determinazione di alcuni parametri biochimici in uno studio multicentrico sulla epidemiologia della colelitiasi. Giornale Italiano di Chimica Clinica. 1990; 15: 275-288. 1990 10. Colombo C, Battezzati PM, Crosignani A, Assaisso M, Ronchi M, Giunta A. Effects of taurine and ursodeoxycholic acid on liver function tests in patients with cystic fibrosis. Acta Univ Carol [Med] (Praha) 1990; 36(1-4):148-51. 1991 11. D. Festi, L. Lalloni, F. Taroni, L. Barbara, A. Menotti, G. Ricci, and the M.I.COL. group The italian multicenter study on epidemiology and prevention of cholelithiasis (MICOL): ultrasonographic standardization. In: Recent Advances in the Epidemiology and Prevention of Gallstone Disease. L. Capocaccia, G. Ricci, F. Angelico, M. Angelico, A.F. Attili, L. Lalloni, Eds. Dordrecht: Kluwer Academic Publishers, 1991, 29-35 1991 12. The M.I.COL. group Prevention of gallstone disease in 18 italian population samples: first results from the MICOL study. In: Recent Advances in the Epidemiology and Prevention of Gallstone Disease. L. Capocaccia, G. Ricci, F. Angelico, M. Angelico, A.F. Attili, L. Lalloni, Eds. Dordrecht: Kluwer Academic Publishers, 1991, 37-44 1991 13. M. Zuin, E. Boga, P.M. Battezzati, A. Crosignani, M. Podda Basic pathophysiology of bile secretion. In: Drugs in Gastroenterology. P.C. Braga, M. Guslandi, A. Tittobello, Eds. New York: Raven Press, 1991, 339-46 1991 14. M. Podda, A. Crosignani, P.M. Battezzati, E. Bertolini, M. Camisasca, C. Colombo, M. Zuin Ursodeoxycholic acid therapy for chronic liver disease. In: Bile Acids as Therapeutic Agents. From Basic Science to Clinical Practice. G. Paumgartner, A. Stiehl, A. Gerok, Eds. Dordrecht: Kluwer Academic Publishers, 1991, 30918 1992 15. M. Podda, A. Crosignani, M. Camisasca, P.M. Battezzati, E. Bertolini, E. Boga, E. Gucciardo, M. Zuin Gli acidi biliari nella terapia delle epatopatie croniche. In: Patologia gastrointestinale. G. Dobrilla, G. De Pretis, M. Colombato (Eds). Verona: Bi & Gi Editori, 1992, 139-151. 1992 16. Podda M, Almasio P, Battezzati PM, Crosignani A, and Italian Multicenter Group for the Study of UDCA in PBC. Long-term effect of the administration of ursodeoxycholic acid alone or with colchicine in patients with primary biliary cirrhosis: a double-blind multicenter study. In: Paumgartner G, Stielh A, Gerok W Editors. Bile acids and the hepatobiliary system. Basel: Kluwer Academic Publishers 1992: 310-15 1993 17. M. Zuin, M. Caimi, ML. Petroni, A. Crosignani, P.M. Battezzati, M. Podda Trattamento della calcolosi colecistica con acidi biliari in: Litiasi Biliare: Recenti approcci terapeutici 1993; 19-30 18 Massimo Zuin, Curriculum vitae 1993 18. M. Podda, P. Almasio, P.M. Battezzati, A. Crosignani, and the Italian Multicenter Group for the Study of UDCA in PBC. Long-term effect of the administration of ursodeoxycholic acid alone or with colchicine in patients with primary biliary cirrhosis: a double-blind multicenter study. In: Bile Acids and the Hepatobiliary System. From Basic Science to Clinical Practice. G. Paumgartner, A. Stiehl, A. Gerok, Eds. Dordrecht: Kluwer Academic Publishers, 1993, 31015 1994 19. M. Podda, P.M. Battezzati, C. Valsania, A. Crosignani, M. Camisasca, E. Bertolini, M. Zuin Clinical management of primary biliary cirrhosis. In: Liver pathophysiology. M.U. Dianzani, P. Gentilini, Eds. Amsterdam: Excerpta Medica 1994, 223-41. 1994 20. M. Podda, A. Crosignani, P. Invernizzi, P.M. Battezzati, C. Valsania, G. De Valle, M. Quagliuolo, L. Fragiacomo, M. Zuin Epidemiology, clinical presentation and treatment of primary biliary cirrhosis. Semin Clin Immunol 1994; 7: 17-32 1994 21. M. Podda, A. Crosignani, G. De Valle, P.M. Battezzati, M. Quagliuolo, L. Fragiacomo, M. Caimi, M.L. Petroni, M. Zuin. Treatment for hepatocellular cholestatic liver diseases. In: Cholestasis. P. Gentilini, I.M. Arias, N. McIntyre, J. Rodes (Eds.). Amsterdam: Excerpta Medica, 1994, 253-266. 1994 22. Podda M, Invernizzi P, De Valle G, Masciadri C, Crosignani A, Battezzati PM, Zuin M. Approccio terapeutico alla cirrosi biliare primitiva: ruolo dell’UDCA In: Familiari M, Borruto A Ed. Up to date in epatologia epato-biliare. Atti dell’VIII Simposio Società Italiana di Endoscopia Digestiva. Taormina 1994: 105-113. 1995 23. M. Podda, A. Crosignani, P.M. Battezzati, P.Invernizzi, C. Colombo, K.D.R. Setchell, M. Zuin Ursodeoxycholic acid for the therapy of chronic cholestatic liver disease: European experience. In: Bile Acids in Gastroenterology. Basic and Clinical Advances. A.F. Hofmann, G. Paumgartner, A. Stiehl, Eds. Dordrecht: Kluwer Academic Publishers, 1995, 364-371. 1995 24. A. Crosignani, G. De Valle, P. Invernizzi, P.M. Battezzati, M. Zuin, M. Podda. Impiego degli acidi biliari nella terapia delle epatopatie croniche. In: Acidi Biliari in Gastroenterologia. M. Angelico, M. Muraca, M. Podda (Eds.). Milano: Kurtis, 1995, 131-160. 1995 25. Tamma F, Battezzati PM, Caputo E, Pieralli S, Zuin M. Encefalopatia epatica e degenerazione epatocerebrale acquisita. Atti XXII Riunione L.I.M.P.E. “L’approccio multidisciplinare alle patologie extrapiramidali”. Trieste 1995: 305-14. 1997 26. M. Podda, A. Crosignani, A. Larghi, P.M. Battezzati, P. Invernizzi, M. Allocca, M. Zuin Treatment of vanishing bile duct syndrome with ursodeoxycholic acid. In: D. Alvaro, A. Benedetti, M. Strazzabosco, Eds. Vanishing Bile Duct Syndrome. Pathophysiology and Treatment. Dordrecht: Kluwer Academic Publishers, 1997, 224-229. 1998 27. Podda M, Crosignani A, Battezzati PM, Zuin M. La Cirrosi Biliare Primitiva. Aspetti clinici. Atti del 99° Congresso della Società Italiana di Medicina Interna. Roma 1998: 219-50. 19 Massimo Zuin, Curriculum vitae 2003 28. Selmi C, Invernizzi P, Tripputi P, Battezzati PM, Bignotto M, Zuin M, Crosignani A, Podda M T-cell receptor polymorphism in primary biliary cirrhosis. Ann Ital Med Int. 2003;18:149-153 2007 29. Selmi C, invernizzi P, Zuin M, Battezzati PM, Gershwin ME. Geoepidemiology of primary biliary cirrhosis. In: Diehl AM, Hayashi N, Manns MP, Sauerbruch T, Eds. Chronic hepatitis: Metabolic,Cholestatic, viral and autoimmune. 2007, 54-65. Dordrecht, The Netherlands: Springer (ISBN: 13978-1-4020-6522-4) Milano, 10 giugno 2015 Massimo Zuin 20