In Vitro BCOP BRD: Appendix C1 March 2006

BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Alkyl phosphoric acid ester/amine salt
Aromatic hydrocarbon #1
Aromatic hydrocarbon #2
Aryl phosponates
Carboxylic acid amides
2-Chloro-2,4,4-trimethylpentane
Clarified slurry oil
Cutting fluid (conc.) #1
Cutting fluid (conc.) #2
Ethylhexyl acid phosphate ester
5-Ethylidene-2-norbornene
Methyl cyclopentadiene dimer
Petroleum wax
Polyalkenylsuccinate ester/amine salt
Process oil
Thiadiazole alkyl derivative
Acetone
Acetone
Acetone
Acetone
Acetone
Ammonium nitrate
Ammonium nitrate
Ammonium nitrate
Ammonium nitrate
Ammonium nitrate
L-Aspartic acid
L-Aspartic acid
L-Aspartic acid
L-Aspartic acid
L-Aspartic acid
Benzalkonium chloride (10%)
Benzalkonium chloride (10%)
Benzalkonium chloride (10%)
Benzalkonium chloride (10%)
Benzalkonium chloride (10%)
Benzalkonium chloride (5%)
Benzalkonium chloride (5%)
Benzalkonium chloride (5%)
Benzalkonium chloride (5%)
Benzalkonium chloride (5%)
Benzalkonium chloride (1 %)
Benzalkonium chloride (1 %)
Benzalkonium chloride (1 %)
Benzalkonium chloride (1 %)
Benzalkonium chloride (1 %)
Benzoyl-L-tartaric acid
Benzoyl-L-tartaric acid
Benzoyl-L-tartaric acid
Benzoyl-L-tartaric acid
Benzoyl-L-tartaric acid
Butyl acetate
Butyl acetate
Butyl acetate
Butyl acetate
Butyl acetate
CASRN
16219-75-3
67-64-1
67-64-1
67-64-1
67-64-1
67-64-1
6484-52-2
6484-52-2
6484-52-2
6484-52-2
6484-52-2
70-47-3
70-47-3
70-47-3
70-47-3
70-47-3
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
123-86-4
123-86-4
123-86-4
123-86-4
123-86-4
Form
Tested
liquid
liquid
liquid
liquid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
Solubility
Concentration
Tested
Purity (%)
Lab
No.
moderate
negligible
negligible
moderate
moderate
negligible
negligible
emulsifies
emulsifies
moderate
negligible
negligible
negligible
moderate
negligible
negligible
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
water insoluble
water insoluble
water insoluble
water insoluble
water insoluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
10%
10%
10%
10%
10%
5%
5%
5%
5%
5%
1%
1%
1%
1%
1%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
99
99
99
99
99
>99.9
>99.9
>99.9
>99.9
>99.9
100
100
100
100
100
98
98
98
98
98
98
98
98
98
98
98
98
98
98
98
99
99
99
99
99
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
Mean
Opacity
37.7
2.7
4.3
20.3
10.7
4.0
2.3
3.3
4.3
117.3
5.7
0.7
0.3
2.3
2.7
7.3
90.3
83.7
55.7
94.33
69.3
6.3
6
6
11.34
4.7
2
1.7
2.7
0.33
0
75.3
79.3
61.7
63
74.7
126.6
163.7
110.7
130.41
111.1
59
37
34.3
22
38
169.7
286.7
90
147
141.3
9
7.7
5.7
5
2.3
n
C-5
SD Opacity
Mean
OD490
3.577
0.000
0.017
1.399
1.125
0.004
0.000
0.001
0.038
0.880
0.207
0.001
-0.001
0.000
0.004
0.237
3.676
2.389
4.315
2.492
1.942
0.132
0.026
0.079
0.698
0.034
-0.011
-0.107
-0.003
0.03
0.082
4.456
5.223
4.142
4.967
3.096
3.264
6.599
3.891
4.338
3.117
3.588
3.566
4.336
2.699
2.706
0.218
0.134
0.073
0.191
0.266
2.7
1.989
2.546
1.257
1.051
n
SD OD490
In Vitro
Score1
91.3
2.7
4.6
41.3
27.5
4.1
2.3
3.5
4.9
130.5
8.8
0.7
0.3
2.3
2.7
10.9
145.5
119.5
120.4
131.72
98.4
8.3
6.4
7.2
21.82
5.2
1.8
0.1
2.6
0.788
1.2
142.2
157.7
123.8
137.5
121.1
126.6
163.7
110.7
130.41
111.1
112.8
90.5
99.4
62.49
78.6
173
288.7
91.1
149.86
145.3
49.5
37.5
43.9
23.86
18.1
n
SD Score
In Vitro
Consensus
Classification2
Severe
Mild
Mild
Moderate
Moderate
Mild
Mild
Mild
Mild
Severe
Mild
Mild
Mild
Mild
Mild
Moderate
Very severe
Very severe
Very severe
Very severe
Very severe
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Severe
Severe
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Moderate
Moderate
Mild
Mild
Classification3
Severe
Mild
Mild
Moderate
Moderate
Mild
Mild
Mild
Mild
Severe
Mild
Mild
Mild
Mild
Mild
Moderate
Very Severe
Mild
Mild
Very Severe
Very Severe
Very Severe
Very Severe
Moderate
Reference
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Bailey et al. (2004)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
gamma-Butyrolactone
gamma-Butyrolactone
gamma-Butyrolactone
gamma-Butyrolactone
gamma-Butyrolactone
Captan 90 concentrate
Captan 90 concentrate
Captan 90 concentrate
Captan 90 concentrate
Captan 90 concentrate
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
Cetylpyridinium bromide (6%)
Cetylpyridinium bromide (6%)
Cetylpyridinium bromide (6%)
Cetylpyridinium bromide (6%)
Cetylpyridinium bromide (6%)
Cetylpyridinium bromide (10%)
Cetylpyridinium bromide (10%)
Cetylpyridinium bromide (10%)
Cetylpyridinium bromide (10%)
Cetylpyridinium bromide (10%)
Cetylpyridinium bromide (0.1%)
Cetylpyridinium bromide (0.1%)
Cetylpyridinium bromide (0.1%)
Cetylpyridinium bromide (0.1%)
Cetylpyridinium bromide (0.1%)
Chlorhexidine
Chlorhexidine
Chlorhexidine
Chlorhexidine
Chlorhexidine
Cyclohexanol
Cyclohexanol
Cyclohexanol
Cyclohexanol
Cyclohexanol
Dibenzyl phosphate
Dibenzyl phosphate
Dibenzyl phosphate
Dibenzyl phosphate
Dibenzyl phosphate
2,6-Dichlorobenzoyl chloride
2,6-Dichlorobenzoyl chloride
2,6-Dichlorobenzoyl chloride
2,6-Dichlorobenzoyl chloride
2,6-Dichlorobenzoyl chloride
2,2-Dimethylbutanoic acid
2,2-Dimethylbutanoic acid
2,2-Dimethylbutanoic acid
2,2-Dimethylbutanoic acid
2,2-Dimethylbutanoic acid
2,5-Dimethylhexanediol
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
133-06-2
133-06-2
133-06-2
133-06-2
133-06-2
619-66-9
619-66-9
619-66-9
619-66-9
619-66-9
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
140-72-7
55-56-1
55-56-1
55-56-1
55-56-1
55-56-1
108-93-0
108-93-0
108-93-0
108-93-0
108-93-0
1623-08-1
1623-08-1
1623-08-1
1623-08-1
1623-08-1
4659-45-4
4659-45-4
4659-45-4
4659-45-4
4659-45-4
595-37-9
595-37-9
595-37-9
595-37-9
595-37-9
110-03-2
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble
water insoluble
water insoluble
water insoluble
water insoluble
water insoluble
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
6%
6%
6%
6%
6%
10%
10%
10%
10%
10%
0.10%
0.10%
0.10%
0.10%
0.10%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
>99
>99
>99
>99
>99
90
90
90
90
90
95
95
95
95
95
98
98
98
98
98
98
98
98
98
98
98
98
98
98
98
n.p.
n.p.
n.p.
n.p.
n.p.
97
97
97
97
97
99
99
99
99
99
99
99
99
99
99
96
96
96
96
96
99.5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
37.3
22.7
22
48.67
31.7
28
26.3
34.7
102
26.3
97.3
96.3
57.3
64
72
31.7
38.3
18.3
25.33
34
22.7
27.7
24.7
17
23
6.7
1.7
3
3.33
6.3
141
124
96.3
97.66
98.7
18.3
7.3
12
11.66
7
304.3
389.3
418
467
304
9
10.3
9.7
14.33
5.4
65
58.3
62.7
84
37
12
n
C-6
SD Opacity
Mean
OD490
3.553
0.682
0.63
2.192
2.357
-0.008
0.055
0.007
0.061
0.004
0.02
0.116
0.012
0.022
0.128
2.705
3.195
3.015
2.892
2.097
1.389
4.128
3.759
3.97
3.58
0.293
0.163
0.606
0.066
0.543
0.399
-0.071
0.062
0.277
0.189
4.442
2.838
3.87
2.71
2.392
-0.017
0.117
-0.002
-0.016
0.234
0.058
0.059
0.078
0.007
0.012
2.583
3.78
4.601
3.803
2.783
0.415
n
SD OD490
In Vitro
Score1
90.6
32.9
31.5
81.55
67.1
27.8
27.2
34.8
102.918
26.4
97.6
98.1
57.5
64.33
73.9
72.2
86.3
63.6
68.72
65.4
43.5
89.6
81
71.22
76.7
11
4.1
12.1
4.33
14.5
147
122.9
97.3
101.78
101.5
85
49.9
70.1
52.24
43.2
304.1
391.1
418
467.09
307.5
9.9
11.2
10.8
14.43
5.6
103.8
115
131.7
130.26
78.8
18.2
n
SD Score
In Vitro
Consensus
Classification2
Very severe
Moderate
Moderate
Very severe
Severe
Moderate
Moderate
Moderate
Very severe
Moderate
Very severe
Very severe
Severe
Severe
Severe
Severe
Very severe
Severe
Severe
Severe
Moderate
Very severe
Very severe
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Severe
Moderate
Moderate
Very severe
Very severe
Very severe
Very severe
Very severe
Mild
Mild
Mild
Mild
Mild
Very severe
Very severe
Very severe
Very severe
Severe
Mild
Classification3
Severe
Moderate
Severe
Severe
Very Severe
Mild
Very Severe
Moderate
Very Severe
Mild
Very Severe
Mild
Reference
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
2,5-Dimethylhexanediol
2,5-Dimethylhexanediol
2,5-Dimethylhexanediol
2,5-Dimethylhexanediol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethyl acetate
Ethyl acetate
Ethyl acetate
Ethyl acetate
Ethyl acetate
2-Ethyl-1-hexanol
2-Ethyl-1-hexanol
2-Ethyl-1-hexanol
2-Ethyl-1-hexanol
2-Ethyl-1-hexanol
Ethyl-2-methylacetoacetate
Ethyl-2-methylacetoacetate
Ethyl-2-methylacetoacetate
Ethyl-2-methylacetoacetate
Ethyl-2-methylacetoacetate
Ethyl trimethyl acetate
Ethyl trimethyl acetate
Ethyl trimethyl acetate
Ethyl trimethyl acetate
Ethyl trimethyl acetate
Fomesafen
Fomesafen
Fomesafen
Fomesafen
Fomesafen
Glycerol
Glycerol
Glycerol
Glycerol
Glycerol
n-Hexanol
n-Hexanol
n-Hexanol
n-Hexanol
n-Hexanol
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Isobutanol
Isobutanol
Isobutanol
Isobutanol
Isobutanol
Isopropanol
Isopropanol
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
110-03-2
110-03-2
110-03-2
110-03-2
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
141-78-6
141-78-6
141-78-6
141-78-6
141-78-6
104-76-7
104-76-7
104-76-7
104-76-7
104-76-7
609-14-3
609-14-3
609-14-3
609-14-3
609-14-3
3938-95-2
3938-95-2
3938-95-2
3938-95-2
3938-95-2
72128-02-0
72128-02-0
72128-02-0
72128-02-0
72128-02-0
56-81-5
56-81-5
56-81-5
56-81-5
56-81-5
111-27-3
111-27-3
111-27-3
111-27-3
111-27-3
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
78-83-1
78-83-1
78-83-1
78-83-1
78-83-1
67-63-0
67-63-0
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
water insoluble
water insoluble
water insoluble
water insoluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble
water soluble
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
99.5
99.5
99.5
99.5
n.p.
n.p.
n.p.
n.p.
n.p.
99
99
99
99
99
99
99
99
99
99
97
97
97
97
97
99
99
99
99
99
97.5
97.5
97.5
97.5
97.5
>99.5
>99.5
>99.5
>99.5
>99.5
98
98
98
98
98
99
99
99
99
99
99.9
99.9
99.9
99.9
99.9
99.9
99.9
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
10.7
6.7
21.33
4.7
31
21.3
16.3
36
30
8.7
5.7
9
13.33
11
8.3
9
4.3
7
7
26.7
14.3
5.7
5.33
18.7
10.3
5
1.3
5.33
3.6
2.6
4.3
6.3
13
5.7
-2
-0.7
0
3
0
17.7
16
7
15.33
10.7
68.3
93
62.3
97.34
54.3
17
20
19
26
21.4
11.7
23.3
n
SD Opacity
Mean
OD490
0.979
0.925
0.68
0.245
2.893
2.123
3.134
4.134
2.277
0.737
1.513
2.543
2.065
0.64
3.58
1.279
1.761
3.347
0.837
0.052
-0.014
-0.012
0.014
0.061
1.136
1.916
0.609
0.22
0.357
2.859
9.837
3.904
0.668
0.834
-0.001
0.029
0.018
0.005
0.01
3.591
4.509
3.746
2.191
2.145
3.232
2.724
2.741
1.424
2.431
2.494
3.598
3.248
1.052
1.39
1.868
2.409
n
SD OD490
In Vitro
Score1
25.3
20.5
31.533
8.3
74.4
53.2
63.3
98.01
64.2
19.7
28.4
47.1
44.31
20.6
62
28.2
30.7
58.71
19.6
27.5
14.1
5.5
5.543
19.6
27.4
33.7
10.5
8.633
9
45.5
151.9
64.9
23.023
18.2
-2
-0.2
0.3
3.08
0.1
71.5
83.6
63.2
48.19
42.9
116.8
133.9
103.4
118.7
90.8
54.4
74
67.7
41.78
42.2
39.7
59.5
n
SD Score
In Vitro
Consensus
Classification2
Moderate
Mild
Moderate
Mild
Severe
Moderate
Severe
Very severe
Severe
Mild
Moderate
Moderate
Moderate
Mild
Severe
Moderate
Moderate
Severe
Mild
Moderate
Mild
Mild
Mild
Mild
Moderate
Moderate
Mild
Mild
Mild
Moderate
Very severe
Severe
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Severe
Very severe
Severe
Moderate
Moderate
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Severe
Severe
Moderate
Moderate
Moderate
Severe
Classification3
Mild
Severe
Moderate
Nonsevere
Mild
Mild
Nonsevere
Mild
Severe/Very
Severe
Very Severe
Moderate
Severe
C-7
Reference
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Isopropanol
Isopropanol
Isopropanol
Maneb
Maneb
Maneb
Maneb
Maneb
Methyl acetate
Methyl acetate
Methyl acetate
Methyl acetate
Methyl acetate
Methyl cyanoacetate
Methyl cyanoacetate
Methyl cyanoacetate
Methyl cyanoacetate
Methyl cyanoacetate
Methylcyclopentane
Methylcyclopentane
Methylcyclopentane
Methylcyclopentane
Methylcyclopentane
Methyl ethyl ketone
Methyl ethyl ketone
Methyl ethyl ketone
Methyl ethyl ketone
Methyl ethyl ketone
Methyl isobutyl ketone
Methyl isobutyl ketone
Methyl isobutyl ketone
Methyl isobutyl ketone
Methyl isobutyl ketone
1-Naphthalene acetic acid
1-Naphthalene acetic acid
1-Naphthalene acetic acid
1-Naphthalene acetic acid
1-Naphthalene acetic acid
1-Naphthalene acetic acid, Na salt
1-Naphthalene acetic acid, Na salt
1-Naphthalene acetic acid, Na salt
1-Naphthalene acetic acid, Na salt
1-Naphthalene acetic acid, Na salt
n-Octanol
n-Octanol
n-Octanol
n-Octanol
n-Octanol
Parafluoraniline
Parafluoraniline
Parafluoraniline
Parafluoraniline
Parafluoraniline
Polyethylene glycol 400
Polyethylene glycol 400
Polyethylene glycol 400
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
67-63-0
67-63-0
67-63-0
12427-38-2
12427-38-2
12427-38-2
12427-38-2
12427-38-2
79-20-9
79-20-9
79-20-9
79-20-9
79-20-9
105-34-0
105-34-0
105-34-0
105-34-0
105-34-0
96-37-7
96-37-7
96-37-7
96-37-7
96-37-7
78-93-3
78-93-3
78-93-3
78-93-3
78-93-3
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
86-87-3
86-87-3
86-87-3
86-87-3
86-87-3
61-31-4
61-31-4
61-31-4
61-31-4
61-31-4
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
371-40-4
371-40-4
371-40-4
371-40-4
371-40-4
25322-68-3
25322-68-3
25322-68-3
liquid
liquid
liquid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble
water insoluble
water insoluble
water insoluble
water insoluble
surfactant
surfactant
surfactant
100%
100%
100%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
99.9
99.9
99.9
90
90
90
90
90
98
98
98
98
98
99
99
99
99
99
>99
>99
>99
>99
>99
99
99
99
99
99
98
98
98
98
98
96
96
96
96
96
95
95
95
95
95
>99
>99
>99
>99
>99
99
99
99
99
99
n.p.
n.p.
n.p.
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
16
30.66
18.3
67.6
17
21
56.33
33.3
51.6
42
38.3
43.1
45.3
16.3
6.7
10.3
17.33
11
1.3
2.3
0.3
1
0.3
68
51.3
34
58
51.7
4.7
8.7
5.7
8
5.7
119.4
65.7
41
86.67
70
73.3
83
73
108
94.7
11
13
10
6
6
17.3
11.3
18.7
18
13.3
0.3
2
-1.7
n
C-8
SD Opacity
Mean
OD490
3.755
3.189
1.4
-0.045
-0.008
-0.002
0.495
0.029
1.301
0.299
0.887
0.72
0.384
0.002
-0.052
-0.015
0.013
-0.003
0.169
0.152
0.071
0.047
0.161
1.665
1.069
1.212
1.38
0.607
0.273
0.759
0.307
0.35
0.305
0.095
0.045
0.065
0.137
0.168
4.177
4.124
5.864
3.55
3.222
2.159
4.392
1.984
0.569
1.464
0.809
1.006
1.474
0.8996
0.679
0.019
0.036
0.021
n
SD OD490
In Vitro
Score1
72.3
78.5
39.3
67
16.9
21
63.76
33.8
71.2
46.5
51.6
53.9
51.1
16.3
5.9
10.1
17.53
11
3.8
4.6
1.4
1.71
2.7
93
67.4
52.2
78.71
60.8
8.8
20.1
10.3
13.25
10.3
120.8
66.3
42
88.73
72.5
136
144.9
161
161.2
143
43.4
78.9
39.8
14.54
28
29.5
26.4
40.8
31.82
23.5
0.6
2.5
-1.3
n
SD Score
In Vitro
Consensus
Classification2
Severe
Severe
Moderate
Severe
Mild
Mild
Severe
Moderate
Severe
Moderate
Moderate
Moderate
Moderate
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Very severe
Severe
Moderate
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Very severe
Severe
Moderate
Very severe
Severe
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Severe
Moderate
Mild
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Mild
Mild
Nonirritant
Classification3
Severe
Nonsevere
Moderate
Mild
Mild
Severe
Mild
Very Severe
Very Severe
Moderate
Moderate
Mild
Reference
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Polyethylene glycol 400
Polyethylene glycol 400
Potassium cyanate
Potassium cyanate
Potassium cyanate
Potassium cyanate
Potassium cyanate
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (1%)
Sodium hydroxide (1%)
Sodium hydroxide (1%)
Sodium hydroxide (1%)
Sodium hydroxide (1%)
Sodium lauryl sulfate (3 %)
Sodium lauryl sulfate (3 %)
Sodium lauryl sulfate (3 %)
Sodium lauryl sulfate (3 %)
Sodium lauryl sulfate (3 %)
Sodium lauryl sulfate (15 %)
Sodium lauryl sulfate (15 %)
Sodium lauryl sulfate (15 %)
Sodium lauryl sulfate (15 %)
Sodium lauryl sulfate (15 %)
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium perborate
Sodium perborate
Sodium perborate
Sodium perborate
Sodium perborate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
25322-68-3
25322-68-3
590-28-3
590-28-3
590-28-3
590-28-3
590-28-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
62-76-0
62-76-0
62-76-0
62-76-0
62-76-0
10486-00-7
10486-00-7
10486-00-7
10486-00-7
10486-00-7
5392-28-9
5392-28-9
5392-28-9
5392-28-9
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
surfactant
surfactant
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
10%
10%
10%
10%
10%
1%
1%
1%
1%
1%
3%
3%
3%
3%
3%
15%
15%
15%
15%
15%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
n.p.
n.p.
97
97
97
97
97
98
98
98
98
98
>99.9
>99.9
>99.9
>99.9
>99.9
n.p.
n.p.
n.p.
n.p.
n.p.
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
98
98
98
98
98
98
98
98
98
98
>99
>99
>99
>99
>99
98.6
98.6
98.6
98.6
98.6
97
97
97
97
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
1
2.7
8.7
11
8.3
7
3
120.7
87.7
125
121.33
153.7
73.7
83.7
61
87.33
74.7
1
0.3
1.7
2.34
2
232.3
173.3
197
283
197.3
100.3
80.7
88.7
116.66
88
12.3
3.3
0.3
6
0
4
6
3.3
1.66
7.7
1.3
6.7
3
43
4
10
13.7
10
11
9.7
24
8.3
14.3
21.33
n
C-9
SD Opacity
Mean
OD490
0.005
0.01
0.499
0.793
0.248
0.692
0.234
-0.022
-0.234
0.044
0.051
0.011
4.468
4.117
4.763
7.445
3.204
-0.047
0.002
0.028
-0.033
0.07
3.53
3.382
3.849
4.329
3.321
4.471
3.504
3.856
3.628
2.888
1.29
1.892
1.801
1.348
0.82
2.884
5.801
3.988
3.862
3.042
0.054
0.059
0.187
0.556
0.081
8.908
6.982
5.749
3.568
3.547
-0.023
-0.027
-0.008
-0.045
n
SD OD490
In Vitro
Score1
1.08
2.8
16.2
22.9
12
17.38
6.5
120.3
84.2
125.7
123.09
153.8
140.7
145.4
132.4
199.02
122.7
0.3
0.4
2.1
1.85
3.1
285.2
224.1
254.7
348.27
247.2
167.4
133.2
146.5
171.08
132.3
31.7
31.7
27.3
26.22
12.3
47.3
93
63.2
59.61
53.3
2.1
7.6
5.8
49.59
4.9
143.6
118.4
96.2
64.531
62.9
23.6
7.9
14.2
20.65
n
SD Score
In Vitro
Consensus
Classification2
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Mild
Mild
Mild
Mild
Mild
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Moderate
Moderate
Moderate
Mild
Moderate
Very severe
Severe
Severe
Moderate
Mild
Mild
Mild
Moderate
Mild
Very severe
Very severe
Very severe
Severe
Severe
Mild
Mild
Mild
Mild
3
Classification
Mild
Mild
Very Severe
Very Severe
Mild
Very Severe
Very Severe
Moderate
Severe
Mild
Very Severe
Mild
Reference
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Tetraaminopyrimidine sulfate
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Toluene
Toluene
Toluene
Toluene
Toluene
Trichloroacetic acid (30%)
Trichloroacetic acid (30%)
Trichloroacetic acid (30%)
Trichloroacetic acid (30%)
Trichloroacetic acid (30%)
Trichloroacetic acid (3%)
Trichloroacetic acid (3%)
Trichloroacetic acid (3%)
Trichloroacetic acid (3%)
Trichloroacetic acid (3%)
Triton X-100 (5 %)
Triton X-100 (5 %)
Triton X-100 (5 %)
Triton X-100 (5 %)
Triton X-100 (5 %)
Triton X-100 (10%)
Triton X-100 (10%)
Triton X-100 (10%)
Triton X-100 (10%)
Triton X-100 (10%)
Tween 20
Tween 20
Tween 20
Tween 20
Tween 20
Anti-Dandruff Shampoo (HZY)
Baby Shampoo No. 1 (HZP)
Baby Shampoo No. 2 (HZF)
Bubble Bath (HZK)
Cleansing Gel (HZQ)
Eye Make-Up Remover (HZH)
Facial Cleanser (HZZ)
Foam Bath (HZL)
Gel Cleanser (HZE)
Mild Shampoo (HZJ)
Polishing Scrub (HZT)
Shampoo No. 2 (HZX)
Shampoo No. 7 (HZA)
Shower Gel (HZS)
Skin Cleanser (HZI)
Acetone
Benzalkonium chloride (1%)
Benzalkonium chloride (10%)
Benzalkonium chloride (5%)
4-Bromophenetole
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
5392-28-9
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
108-88-3
108-88-3
108-88-3
108-88-3
108-88-3
76-03-9
76-03-9
76-03-9
76-03-9
76-03-9
76-03-9
76-03-9
76-03-9
76-03-9
76-03-9
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9005-64-5
9005-64-5
9005-64-5
9005-64-5
9005-64-5
67-64-1
8001-54-5
8001-54-5
8001-54-5
-
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
liquid
liquid
liquid
liquid
n.p.
water insoluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
water soluble
surfactant
surfactant
surfactant
n.p.
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
30%
30%
30%
30%
30%
3%
3%
3%
3%
3%
5%
5%
5%
5%
5%
10%
10%
10%
10%
10%
n.p.
n.p.
n.p.
n.p.
n.p.
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
1%
10%
5%
100%
97
>99
>99
>99
>99
>99
99
99
99
99
99
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
reagent grade
98
98
98
98
98
98
98
98
98
98
98
98
98
98
98
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
1
2
3
4
5
-
6
88
106.3
82
81.01
74
9.3
6
5.3
2
4
228
154.7
245.3
277
157
79.3
49
73.7
92.33
78.4
5.3
8.3
3.7
5
7.7
6
6.7
6
3.33
7.7
-0.7
-0.3
-2
2.67
0.1
0.092
-0.02
0.067
0.007
0.034
0.034
0.067
0.094
0.009
-0.007
0.027
0.087
0.113
0.189
0.127
1.38
0.970
1.612
1.332
0.079
n
C-10
SD Opacity
Mean
OD490
0.19
4.095
2.19
3.572
3.76
1.671
2.26
1.813
2.122
2.427
1.473
2.93
4.687
3.44
3.072
3.115
0.173
0.053
0.111
0.042
0.067
4.6
6.553
5.099
4.79
3.06
5.312
4.624
5.337
3.617
2.567
0.006
-0.052
0.026
0.0003
0.026
0.182
0.062
0.265
0.103
0.073
0.068
0.001
0.238
0.124
0.01
0.015
0.184
0.205
0.303
0.261
0.653
0.764
1.180
0.776
0.018
n
SD OD490
In Vitro
Score1
8.9
149.4
139.2
135.6
137.44
99.1
43.3
33.2
37.2
38.41
26.1
272
225
296.9
323.08
203.7
81.9
49.8
75.3
92.97
79.3
74.3
106.6
80.2
76.79
53.6
85.7
76
86.1
57.58
46.2
-0.6
-1.1
-1.6
2.711
0.4
n
SD Score
In Vitro
Classification2
Mild
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Moderate
Moderate
Moderate
Moderate
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Severe
Very severe
Severe
Severe
Very severe
Very severe
Very severe
Moderate
Very severe
Severe
Very severe
Severe
Moderate
Mild
Mild
Mild
Mild
Mild
Moderate
Mild
Moderate
Moderate
Mild
Mild
Mild
Moderate
Mild
Mild
Mild
Moderate
Moderate
Moderate
Moderate
Severe
Severe
Severe
Severe
Mild
Consensus
Mild
Classification3
Very Severe
Moderate
Very Severe
Severe/Very
Severe
Very Severe
Severe/Very
Severe
Mild
Moderate
Mild
Moderate
Moderate
Mild
Mild
Mild
Moderate
Mild
Mild
Mild
Moderate
Moderate
Moderate
Moderate
Severe
Severe
Severe
Severe
Mild
Reference
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Balls et al. (1995)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
n-Butanol
2-Butoxyethanol
4-Carboxybenzaldehyde
Cetylpyridinium bromide (0.1%)
Cetylpyridinium bromide (1%)
Cetylpyridinium bromide (10%)
Cetylpyridinium bromide (6%)
Cyclohexanol
2,6-Dichlorobenzoyl chloride
2,4-Difluoronitrobenzene
1,3-Diisopropylbenzene
2,2-Dimethylbutanoic acid
Dodecane
2-Ethylhexanol
3-Ethyltoluene
Ethyl trimethyl acetate
Glycerol
1,5-Hexadiene
Isobutanol
Isopropanol
Methyl acetate
Methyl ethyl ketone
Methyl isobutyl ketone
1-Methylpropyl benzene
Parafluoraniline
Polyethylene glycol 400
Polyethylene glycol 600
Propylene glycol
Sodium hydroxide (1%)
Sodium hydroxide (10%)
Sodium lauryl sulfate (15 %)
Sodium lauryl sulfate (3 %)
Sodium lauryl sulfate (30 %)
Toluene
Trichloroacetic acid (3%)
Trichloroacetic acid (30%)
Triton X-100 (5%)
Triton X-100 (1%)
Triton X-100 (10%)
Tween 20
Xylene
Amway all fabric bleach
Amway automatic dishwashing
compound for soft water
Amway automatic dishwashing
compound, standard formula
Amway concrete floor cleaner
Amway Dish Drops dishwashing liquid
Amway dry chlorine bleach
Amway fabric softener
Amway Kool Wash delicate fabric
detergent
Amway LOC all purpose cleaner
Amway prewash liquid
Amway Pursue disinfectant cleaner
Amway Redu dye stain remover
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
71-36-3
111-76-2
619-66-9
140-72-7
140-72-7
140-72-7
140-72-7
108-93-0
4659-45-4
446-35-5
99-62-7
595-37-9
112-40-3
104-76-7
620-14-4
3938-95-2
56-81-5
592-42-7
78-83-1
67-63-0
79-20-9
78-93-3
108-10-1
135-98-8
371-40-4
25322-68-3
57-55-6
1310-73-2
1310-73-2
151-21-3
151-21-3
151-21-3
108-88-3
76-03-9
76-03-9
9002-93-1
9002-93-1
9002-93-1
9005-64-5
1330-20-7
-
liquid
liquid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
n.p.
n.p.
n.p.
water insoluble*
surfactant
surfactant
surfactant
surfactant
water soluble
water insoluble*
n.p.
n.p.
water insoluble
n.p.
water soluble
n.p.
water insoluble*
water soluble
n.p.
water insoluble*
water soluble
water soluble
water soluble
water insoluble*
n.p.
water insoluble
surfactant
surfactant
n.p.
water soluble
water soluble
surfactant
surfactant
surfactant
water insoluble*
water soluble
water soluble
surfactant
surfactant
surfactant
surfactant
n.p.
n.p.
100%
100%
100%
0%
1%
10%
6%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
1%
10%
15%
3%
30%
100%
3%
30%
5%
1%
10%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
-
0.414
0.394
0.331
0.082
0.425
0.855
0.908
0.312
0.124
0.049
0.029
1.30
0.086
0.321
0.029
0.330
-0.020
0.164
0.453
0.593
1.07
1.110
0.413
0.041
0.413
-0.015
-0.013
0.076
1.69
1.97
0.163
0.040
0.095
0.420
0.029
1.43
0.281
0.083
0.281
-0.006
0.220
0.400
0.671
1.160
0.002
0.089
0.364
0.705
0.775
0.647
0.106
0.008
0.000
1.11
0.006
0.352
0.009
0.257
0.013
0.085
0.688
0.526
0.236
0.395
0.172
0.005
0.106
0.008
0.008
0.024
1.28
1.23
0.424
0.113
0.312
0.805
0.011
0.031
0.564
0.063
1.003
0.005
0.257
1.435
-
n.p.
n.p.
100%
n.p.
-
2.249
1.381
n
SD Opacity
Mean
OD490
CASRN
n
SD OD490
In Vitro
Score1
n
SD Score
In Vitro
Consensus
Classification2
Severe
Severe
Mild
Mild
Moderate
Severe
Severe
Severe
Mild
Mild
Mild
Severe
Mild
Moderate
Mild
Moderate
Mild
Mild
Severe
Moderate
Moderate
Moderate
Moderate
Mild
Moderate
Mild
Mild
Mild
Severe
Severe
Moderate
Mild
Moderate
Severe
Mild
Severe
Moderate
Mild
Severe
Mild
Moderate
Severe
Classification3
Severe
Severe
Mild
Mild
Moderate
Severe
Severe
Severe
Mild
Mild
Mild
Severe
Mild
Moderate
Mild
Moderate
Mild
Mild
Severe
Moderate
Moderate
Moderate
Moderate
Mild
Moderate
Mild
Mild
Mild
Severe
Severe
Moderate
Mild
Moderate
Severe
Mild
Severe
Moderate
Mild
Severe
Mild
Moderate
Severe
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Severe
Severe
Casterton et al. (1996)
Moderate
Moderate
Casterton et al. (1996)
Reference
-
n.p.
n.p.
100%
n.p.
-
0.683
0.477
-
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
-
2.205
0.290
0.204
0.089
1.839
0.493
0.311
0.013
Severe
Moderate
Moderate
Mild
Severe
Moderate
Moderate
Mild
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
-
n.p.
n.p.
100%
n.p.
-
0.039
0.326
Moderate
Moderate
Casterton et al. (1996)
-
n.p.
liquid
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
-
0.193
0.142
1.437
0.138
0.050
0.079
0.763
0.028
Mild
Mild
Severe
Mild
Mild
Mild
Severe
Mild
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
Casterton et al. (1996)
C-11
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Amway SA8 laundry liquid
Amway SA8 limited phos laundry
powder
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Allyl alcohol
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
Aluminum hydroxide
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
2-Aminophenol
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Anthracene
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
-
liquid
n.p.
100%
n.p.
-
0.032
Mean
OD490
0.179
-
solid
n.p.
100%
n.p.
-
0.415
0.285
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
107-18-6
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
21645-51-2
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
95-55-6
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
120-12-7
121-54-0
121-54-0
121-54-0
121-54-0
121-54-0
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
surfactant
surfactant
surfactant
surfactant
surfactant
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
10%
10%
10%
10%
10%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
94.1
9.7
6
6
10.9
1.4
n
6
6
C-12
SD Opacity
18.9
2.3
1.4
1.2
1.948
0.012
0.144
0.003
n
6
6
6
6
SD OD490
0.455
0.007
0.188
0.007
In Vitro
Score1
156
138
232
156
132
191
190
166
123
101
200
90
5
4
10
3
5
28
2
4
10
6
2
2
7
5
3
5
6
7
5
6
13
11
5
11
-2
1
-3
0
0
-1
0
0
1
0
-2
2
128
124
163
106
128
n
6
6
6
6
SD Score
14.4
2.3
2.5
1.3
In Vitro
Consensus
Classification2
Moderate
Classification3
Moderate
Moderate
Moderate
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Moderate
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Nonirritant
Mild
Nonirritant
Mild
Mild
Nonirritant
Mild
Mild
Mild
Mild
Nonirritant
Mild
Severe
Severe
Severe
Severe
Severe
Severe
Mild
Mild
Mild
Severe
Reference
Casterton et al. (1996)
Casterton et al. (1996)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
Benzethonium chloride
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
Betaine monohydrate
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
BRIJ-35
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Butyrolactone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Cyclohexanone
Deoxycholic acid, sodium salt
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
121-54-0
121-54-0
121-54-0
121-54-0
121-54-0
121-54-0
121-54-0
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
590-47-6
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
9002-92-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
96-48-0
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
108-94-1
302-95-4
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
surfactant
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
10%
10%
10%
10%
10%
10%
10%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
10%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
Mean
Opacity
84.6
3.1
n
6
6
1.1
6
34.2
76.6
6
6
SD Opacity
3.3
2.3
0.6
3.1
3.9
Mean
OD490
5.42
0.029
-0.002
0.495
4.341
n
6
6
6
6
6
SD OD490
0.949
0.014
0.008
0.199
0.551
In Vitro
Score1
129
142
129
166
no data
142
116
4
1
0
1
1
3
1
-10
4
-1
1
6
0
2
-1
1
0
0
0
0
1
no data
-2
-2
48
44
64
35
35
30
80
32
42
53
35
49
92
108
96
81
130
93
104
90
142
no data
118
108
96
n
6
6
6
6
6
SD Score
14.5
2.2
0.7
5
8.2
In Vitro
Consensus
Classification2
Severe
Severe
Severe
Severe
n.a.
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Nonirritant
Mild
Nonirritant
Mild
Mild
Mild
Mild
Nonirritant
Mild
Mild
Mild
Mild
Mild
Mild
n.a.
Nonirritant
Nonirritant
Moderate
Moderate
Severe
Moderate
Moderate
Moderate
Severe
Moderate
Moderate
Moderate
Moderate
Moderate
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
n.a.
Severe
Severe
Severe
Classification3
Severe
Mild
Mild
Moderate
Severe
C-13
Severe
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Deoxycholic acid, sodium salt
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Diacetone alcohol
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
Dibenzoyl-L-tartaric acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
2,4-Dichloro-5-sulfamoylbenzoic acid
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
302-95-4
302-95-4
302-95-4
302-95-4
302-95-4
302-95-4
302-95-4
302-95-4
302-95-4
302-95-4
302-95-4
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
123-42-2
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2743-38-6
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
2736-23-4
657-24-9
657-24-9
657-24-9
657-24-9
657-24-9
657-24-9
657-24-9
657-24-9
657-24-9
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
Mean
Opacity
13.9
31.1
75.2
19.3
0.7
n
6
6
6
6
6
C-14
SD Opacity
2.6
3.2
14.2
4.8
1.8
Mean
OD490
5.718
4.119
0.416
-0.01
0.097
n
6
6
6
6
6
SD OD490
0.511
1.341
0.116
0.004
0.176
In Vitro
Score1
72
106
73
119
103
88
46
100
60
200
59
53
41
105
39
42
34
49
41
92
no data
36
56
104
134
82
118
110
66
88
193
82
no data
213
135
23
23
18
28
16
31
18
71
19
20
34
14
0
3
1
3
1
5
3
1
2
n
6
6
6
6
6
SD Score
8
22
13.7
4.7
2.6
In Vitro
Consensus
Classification2
Severe
Severe
Severe
Severe
Severe
Severe
Moderate
Severe
Severe
Severe
Severe
Moderate
Moderate
Severe
Moderate
Moderate
Moderate
Moderate
Moderate
Severe
n.a.
Moderate
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
n.a.
Severe
Severe
Mild
Mild
Mild
Moderate
Mild
Moderate
Mild
Severe
Mild
Mild
Moderate
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Classification3
Severe
Moderate
Severe
Mild
Mild
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Mild
Substance
Dimethylbiguanide
Dimethylbiguanide
Dimethylbiguanide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
Dimethyl sulfoxide
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
EDTA, di-potassium salt
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
2-Ethoxyethanol
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
CASRN
Form
Tested
657-24-9
657-24-9
657-24-9
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
67-68-5
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
25102-12-9
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
110-80-5
141-97-9
141-97-9
141-97-9
141-97-9
141-97-9
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
Solubility
Concentration
Tested
Purity (%)
Lab
No.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
Mean
Opacity
6.3
n
6
0.8
6
22.3
61.7
6
6
C-15
SD Opacity
1.7
0.5
4.1
1.9
Mean
OD490
0.204
0.01
1.56
1.515
n
6
6
6
6
SD OD490
0.056
0.014
0.316
0.134
In Vitro
Score1
no data
5
8
10
10
14
11
11
14
10
10
9
no data
4
22
-1
0
-8
2
2
2
1
-6
1
-1
3
1
58
67
70
45
60
64
58
51
46
no data
104
45
99
100
128
75
75
85
94
93
84
75
101
86
26
38
31
33
21
n
6
6
6
6
SD Score
1.4
0.6
6.6
1.2
In Vitro
Consensus
Classification2
n.a.
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
n.a.
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Severe
Severe
Severe
Moderate
Severe
Severe
Severe
Moderate
Moderate
n.a.
Severe
Moderate
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Moderate
Moderate
Moderate
Moderate
Moderate
Classification3
Mild
Mild
Severe
Severe
Moderate
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
Ethyl acetoacetate
Furan
Furan
Furan
Furan
Furan
Furan
Furan
Furan
Furan
Furan
Furan
Furan
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
Gluconolactone
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
DL-Glutamic acid
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
3-Glycidoxypropyltrimethoxysilane
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
141-97-9
141-97-9
141-97-9
141-97-9
141-97-9
141-97-9
141-97-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
110-00-9
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
90-80-2
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
19285-83-7
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
2530-83-8
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
Mean
Opacity
24
n
6
20.6
85.2
-0.2
16.6
6
6
6
6
C-16
SD Opacity
2.9
2.5
5.6
0.5
4.5
Mean
OD490
0.117
1.97
0.154
-0.005
0.065
n
6
6
6
6
6
SD OD490
0.007
0.197
0.041
0.005
0.082
In Vitro
Score1
29
28
38
26
no data
38
42
73
63
61
65
33
34
87
48
50
39
68
51
63
81
90
62
108
66
90
57
88
no data
75
63
2
1
1
1
0
-4
1
4
0
2
0
-1
18
24
25
14
13
6
15
18
18
4
23
21
n
6
6
6
6
6
SD Score
3.8
4
5.3
0.5
4.7
In Vitro
Consensus
Classification2
Moderate
Moderate
Moderate
Moderate
n.a.
Moderate
Moderate
Severe
Severe
Severe
Severe
Moderate
Moderate
Severe
Moderate
Moderate
Moderate
Severe
Moderate
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
n.a.
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Nonirritant
Mild
Mild
Mild
Mild
Mild
Nonirritant
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Classification3
Moderate
Severe
Severe
Mild
Mild
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Mean
Opacity
SD OD490
In Vitro
In Vitro
Consensus
Classification3
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
1
93
Severe
Gautheron et al. (1994)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
2
40
Moderate
Gautheron et al. (1994)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
3
53
Moderate
Gautheron et al. (1994)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
4
33
Moderate
Gautheron et al. (1994)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
5
91
Severe
Gautheron et al. (1994)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
6
42
Moderate
n
Score1
n
SD Score
Classification2
CASRN
n
SD Opacity
Mean
OD490
Substance
Reference
Gautheron et al. (1994)
Severe
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
7
82
Severe
Gautheron et al. (1994)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
8
76
Severe
Gautheron et al. (1994)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
9
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
10
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
Hexane
Hexane
Hexane
Hexane
Hexane
Hexane
Hexane
Hexane
Hexane
Hexane
Hexane
Hexane
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
110-54-3
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
494-19-9
494-19-9
494-19-9
494-19-9
494-19-9
494-19-9
494-19-9
494-19-9
494-19-9
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
18.3
Severe
Gautheron et al. (1994)
no data
n.a.
Gautheron et al. (1994)
11
48
Moderate
Gautheron et al. (1994)
12
102
Severe
Gautheron et al. (1994)
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
2
2
2
0
2
1
3
1
1
-1
-2
6
75
73
140
81
96
62
82
122
64
81
114
65
0
1
6
0
4
0
1
12
0
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Nonirritant
Nonirritant
Mild
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
1.3
6
40.3
0.2
6
6
6
C-17
3.6
1.8
9.9
0.4
3.438
0.002
1.598
-0.001
6
6
6
6
0.562
0.002
0.271
0.003
70
6
6
6
6
6.9
1.8
11.2
0.4
Mild
Severe
Mild
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Mild
Substance
Iminodibenzyl
Iminodibenzyl
Iminodibenzyl
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
N-Lauroylsarcosine, sodium salt
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Laurylsulfobetaine
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
Magnesium carbonate
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
2-Mercaptopyrimidine
Methanol
Methanol
Methanol
Methanol
Methanol
CASRN
Form
Tested
494-19-9
494-19-9
494-19-9
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
7631-98-3
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
14933-08-5
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
56378-72-4
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
1450-85-7
67-56-1
67-56-1
67-56-1
67-56-1
67-56-1
solid
solid
solid
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
Solubility
Concentration
Tested
Purity (%)
Lab
No.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
20%
20%
20%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
Mean
Opacity
7.8
n
6
16.2
0.5
6
6
-0.2
6
C-18
SD Opacity
0.9
4.3
0.5
0.4
Mean
OD490
3.653
5.742
0.016
-0.004
n
6
6
6
6
SD OD490
0.496
1.462
0.004
0.002
In Vitro
Score1
no data
6
-4
53
50
48
28
45
35
48
43
63
no data
89
48
81
82
103
76
92
68
90
62
102
no data
76
55
3
6
3
3
0
1
7
3
1
no data
0
6
0
-1
-1
1
0
1
0
-8
0
0
-4
-3
88
88
54
71
81
n
6
6
6
6
SD Score
7.3
24.8
0.5
0.4
In Vitro
Consensus
Classification2
n.a.
Mild
Nonirritant
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Severe
n.a.
Severe
Moderate
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
n.a.
Severe
Moderate
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
n.a.
Mild
Mild
Mild
Nonirritant
Nonirritant
Mild
Mild
Mild
Mild
Nonirritant
Mild
Mild
Nonirritant
Nonirritant
Severe
Severe
Moderate
Severe
Severe
Classification3
Moderate
Severe
Mild
Mild
Severe
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Methanol
Methanol
Methanol
Methanol
Methanol
Methanol
Methanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
2-Methoxyethanol
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
Methylisobutyl ketone
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
MYRJ-45
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
1-Nitropropane
Octanol
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
67-56-1
67-56-1
67-56-1
67-56-1
67-56-1
67-56-1
67-56-1
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
109-86-4
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-10-1
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
108-03-2
111-87-5
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
water insoluble*
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
Mean
Opacity
73.7
45.1
11.2
0.4
n
6
6
6
6
16.5
6
SD Opacity
6
7.1
2.7
1.4
1.7
Mean
OD490
1.698
0.8
0.546
0.005
0.008
n
6
6
6
6
6
SD OD490
0.56
0.137
0.244
0.004
0.018
In Vitro
Score1
108
37
19
99
no data
179
102
61
69
66
47
48
62
65
62
57
no data
74
88
22
25
27
19
21
23
16
16
19
no data
20
11
2
1
0
1
0
0
1
-4
1
no data
-3
-1
11
8
9
4
6
7
6
6
17
4
6
7
65
n
6
6
6
6
6
SD Score
12.8
8.9
3.1
1.4
1.9
In Vitro
Consensus
Classification2
Severe
Moderate
Mild
Severe
n.a.
Severe
Severe
Severe
Severe
Severe
Moderate
Moderate
Severe
Severe
Severe
Severe
n.a.
Severe
Severe
Mild
Mild
Moderate
Mild
Mild
Mild
Mild
Mild
Mild
n.a.
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Nonirritant
Mild
n.a.
Nonirritant
Nonirritant
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Severe
Classification3
Severe
Severe
Mild
Mild
Mild
C-19
Moderate
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Octanol
Octanol
Octanol
Octanol
Octanol
Octanol
Octanol
Octanol
Octanol
Octanol
Octanol
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
2,4-Pentanedione
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Petroleum ether
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
Phenylbutazone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
111-87-5
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
123-54-6
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
8032-32-4
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
50-33-9
92-43-3
92-43-3
92-43-3
92-43-3
92-43-3
92-43-3
92-43-3
92-43-3
92-43-3
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
Mean
Opacity
27.7
49.1
1.4
n
6
6
6
0.7
6
11.1
6
C-20
SD Opacity
5
3.4
1.9
0.4
1
Mean
OD490
2.212
0.084
0.015
-0.008
0.143
n
6
6
6
6
6
SD OD490
0.377
0.036
0.011
0.008
0.052
In Vitro
Score1
33
42
49
66
48
37
25
61
no data
31
64
61
79
75
34
70
46
54
44
50
67
62
76
8
13
11
1
2
5
7
0
2
3
5
9
0
1
1
0
0
1
0
-6
1
1
-3
2
7
12
15
9
28
6
6
16
13
n
6
6
6
6
6
SD Score
6.9
3.4
1.9
0.4
1.6
In Vitro
Consensus
Classification2
Moderate
Moderate
Moderate
Severe
Moderate
Moderate
Mild
Severe
n.a.
Moderate
Severe
Severe
Severe
Severe
Moderate
Severe
Moderate
Moderate
Moderate
Moderate
Severe
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Nonirritant
Mild
Mild
Nonirritant
Mild
Mild
Mild
Mild
Mild
Moderate
Mild
Mild
Mild
Mild
Classification3
Moderate
Severe
Mild
Mild
Mild
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Mild
Substance
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
1-Phenyl-3-pyrazolidone
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Promethazine hydrochloride
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Pyridine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Quinacrine
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
CASRN
Form
Tested
92-43-3
92-43-3
92-43-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
58-33-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
110-86-1
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
69-05-6
62-76-0
62-76-0
62-76-0
62-76-0
62-76-0
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
Solubility
Concentration
Tested
Purity (%)
Lab
No.
n.p.
n.p.
n.p.
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble*
water soluble
water soluble
water soluble
water soluble
water soluble
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
Mean
Opacity
134.9
5.2
6
6
44.4
57
n
6
6
C-21
SD Opacity
9.7
1.7
3.3
5.4
Mean
OD490
0.287
0.066
4.015
0.063
n
6
6
6
6
SD OD490
0.216
0.059
0.849
0.04
In Vitro
Score1
15
13
15
117
156
109
111
164
174
103
50
139
no data
94
19
7
7
14
4
6
9
6
11
6
no data
12
5
102
123
186
79
102
77
124
132
105
no data
96
115
17
29
8
46
52
24
15
18
58
no data
3
72
2
2
9
5
3
n
6
6
6
6
SD Score
10.2
1.5
15.7
5.8
In Vitro
Consensus
Classification2
Mild
Mild
Mild
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Moderate
Severe
n.a.
Severe
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
n.a.
Mild
Mild
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
n.a.
Severe
Severe
Mild
Moderate
Mild
Moderate
Moderate
Mild
Moderate
Moderate
Severe
n.a.
Mild
Severe
Mild
Mild
Mild
Mild
Mild
Classification3
Severe
Mild
Severe
Moderate
Mild
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Tetraaminopyrimidine sulfate
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
Thiourea
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
1,2,3-Trichloropropane
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
Triethanolamine
1,2,4-Trimethylbenzene
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
62-76-0
62-76-0
62-76-0
62-76-0
62-76-0
62-76-0
62-76-0
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
5392-28-9
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
62-56-6
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
96-18-4
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
102-71-6
95-63-6
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1
Mean
Opacity
1.7
6
2.6
6
85.8
7.7
2.6
n
6
6
6
SD Opacity
0.9
1.4
9.2
1.9
0.9
Mean
OD490
0.103
-0.003
4.373
5.561
0.025
n
6
6
6
6
6
SD OD490
0.042
0.006
1.028
1.398
0.011
In Vitro
Score1
2
4
3
3
9
11
4
5
1
2
6
0
4
2
19
3
no data
18
6
146
175
169
152
140
120
129
173
151
no data
203
104
47
42
78
28
42
47
48
24
91
no data
28
47
2
4
0
0
-1
1
1
3
3
no data
5
6
25
n
6
6
6
6
6
SD Score
1.3
1.4
20.7
20
1
In Vitro
Consensus
Classification2
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
n.a.
Mild
Mild
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
n.a.
Severe
Severe
Moderate
Moderate
Severe
Moderate
Moderate
Moderate
Moderate
Mild
Severe
n.a.
Moderate
Moderate
Mild
Mild
Mild
Mild
Nonirritant
Mild
Mild
Mild
Mild
n.a.
Mild
Mild
Mild
Classification3
Mild
Mild
Severe
Moderate
Mild
C-22
Mild
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
1,2,4-Trimethylbenzene
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Triton X-155
Anti-Dandruff Shampoo (HZY) 100%
Baby Shampoo No. 1 (HZP) 100%
Baby Shampoo No. 2 (HZF) 100%
Bubble Bath (HZK) 100%
Cleansing Gel (HZQ) 100%
Eye Make-Up Remover (HZH) 100%
Facial Cleaning Foam (HZR) 25%
Facial Cleanser (HZZ) 100%
Foam Bath (HZL) 100%
Gel Cleanser (HZE) 100%
Hand Soap (HZU) 25%
Liquid Soap No. 2 (HZW) 25%
Liquid Soap No. 1 (HZB) 25%
Mild Shampoo (HZJ) 25%
Polishing Scrub (HZT) 100%
Shampoo No. 1 (HZC) 25%
Shampoo No. 2 (HZX)
Shampoo No. 3 (HZM) 25%
Shampoo No. 4 (HZV) 25%
Shampoo No. 5 (HZD) 25%
Shampoo No. 6 (HZN) 25%
Shampoo No. 7 (HZA) 100%
Shampoo No. 8 (HZG) 25%
Shower Gel (HZS) 100%
Skin Cleanser (HZI) 100%
Ammonium nitrate
Ammonium nitrate
Ammonium nitrate
Ammonium nitrate
Ammonium nitrate
Ammonium nitrate
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
95-63-6
95-63-6
95-63-6
95-63-6
95-63-6
95-63-6
95-63-6
95-63-6
95-63-6
95-63-6
95-63-6
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
9010-44-0
6484-52-2
6484-52-2
6484-52-2
6484-52-2
6484-52-2
6484-52-2
8001-54-5
8001-54-5
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
liquid
liquid
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
surfactant
surfactant
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
100%
100%
100%
100%
100%
100%
10%
10%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
2
3
4
5
6
7
8
9
10
11
12
1
2
3
4
5
6
7
8
9
10
11
12
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
Mean
Opacity
12.5
3
n
6
6
4.3
5.0
1.6
2.0
3.7
4.3
84.0
85.6
3
3
3
3
3
3
3
3
SD Opacity
1.5
Mean
OD490
0.579
n
6
SD OD490
0.369
1.6
0.008
6
0.014
2.1
1.2
1.2
0.6
0.6
0.6
3.8
3.2
0.847
0.261
0.425
0.956
0.164
0.02
0.239
0.004
0.912
0.194
0.293
0.352
0.199
0.05
-0.001
0.957
0.705
0.214
0.268
0.241
0.267
0.406
0.197
1.548
0.769
0.037
0.059
0.153
0.107
0.100
0.158
7.408
3.305
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
0.199
0.05
0.082
0.324
0.05
0.016
0.02
0.004
0.261
0.048
0.09
0.1
0.024
0.025
0.001
0.306
0.289
0.049
0.045
0.08
0.076
0.156
0.058
0.093
0.036
0.036
0.031
0.059
0.044
0.033
0.07
0.903
0.225
In Vitro
Score1
14
26
11
27
7
9
15
21
10
7
21
-1
1
-1
0
2
2
0
2
3
no data
-2
0
20.8
4.0
8.3
17.5
2.3
0.2
4.1
1.8
18.6
3.1
5.5
5.6
2.3
0.1
3.7
30.0
14.0
4.3
8.4
2.7
4.5
6.6
2.7
35.9
15.8
4.9
5.9
3.9
3.6
5.2
6.7
195.2
135.2
n
6
6
3
3
3
3
3
3
3
3
SD Score
4.5
1.7
2.4
1.4
1.8
1
0.6
1.5
11.3
5.2
In Vitro
Consensus
Classification2
Mild
Moderate
Mild
Moderate
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Nonirritant
Mild
Nonirritant
Mild
Mild
Mild
Mild
Mild
Mild
n.a.
Nonirritant
Mild
Severe
Nonsevere
Nonsevere
Severe
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Severe
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Severe
Severe
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Severe
Severe
Mild
Mild
Mild
Mild
Mild
Mild
Very severe
Very severe
Classification3
Mild
Mild
Severe
Nonsevere
Nonsevere
Severe
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Severe
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Severe
Severe
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Nonsevere
Severe
Severe
Mild
C-23
Very Severe
Reference
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gautheron et al. (1994)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Gettings et al. (1996)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Benzalkonium chloride (100%)
Butyl cellusolve
Butyl cellusolve
Butyl cellusolve
Butyl cellusolve
Butyl cellusolve
Butyl cellusolve
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
4-Carboxybenzaldehyde
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
Ethanol
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
n
SD Opacity
Mean
OD490
n
SD OD490
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
8001-54-5
111-76-2
111-76-2
111-76-2
111-76-2
111-76-2
111-76-2
619-66-9
619-66-9
619-66-9
619-66-9
619-66-9
619-66-9
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
64-17-5
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water insoluble*
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
95
95
95
95
95
95
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
1 (3)
1 (4)
1 (5)
1 (6)
1 (7)
1 (8)
2 (1)
2 (2)
2 (3)
2 (4)
2 (5)
2 (6)
2 (7)
3 (1)
3 (2)
3 (3)
3 (4)
3 (5)
3 (6)
3 (7)
3 (8)
3 (9)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
1 (3)
1 (4)
1 (5)
1 (6)
1 (7)
2 (1)
2 (2)
2 (3)
2 (4)
2 (5)
2 (6)
2 (7)
2 (8)
3 (1)
3 (2)
3 (3)
3 (4)
3 (5)
3 (6)
3 (7)
82.0
85.0
87.7
91.7
98.3
87.7
88.0
94.6
87.0
93.0
98.3
95.7
98.0
96.7
92.6
105.0
95.3
92.3
93.7
100.7
96.7
97.3
39
43
29.6
31.3
37.7
37.7
53.7
47.7
46.3
46.4
42
41.3
17.6
16.4
13.7
12.7
14.7
12.7
18.7
13.3
17.0
16.3
17.3
14.7
17.6
15.0
13.0
16.6
18.0
19.3
22.0
18.6
17.0
19.3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
1.7
5.2
1.7
7.0
2.6
2.9
7.5
10.4
7.5
3.0
2.3
5.0
5.1
2.0
11.8
6.1
4.0
7.2
4.9
2.5
2.0
5.1
7.8
4.0
1.5
2.3
1.0
6.1
4.6
3.5
3.2
2.9
4.5
4.0
2.3
5.5
1.5
1.0
2.1
14.9
1.5
1.0
2.3
4.9
1.5
2.1
0.6
2.6
0.6
2.1
2.9
2.6
2.6
1.5
1.2
3.8
3.729
4.766
3.354
5.67
5.645
5.848
4.426
4.148
4.252
4.278
3.972
4.129
4.144
4.015
4.719
4.316
4.497
3.948
4.624
4.473
9.016
4.183
4.625
4.589
4.213
4.526
3.813
4.031
0.012
0.002
0.05
0.058
0.013
0.035
1.265
1.415
1.062
1.933
1.125
1.995
2.445
2.626
2.504
3.025
2.857
2.636
3.718
3.267
2.561
2.027
1.831
1.673
1.583
2.395
1.853
1.527
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
0.25
1.132
0.108
1.096
0.523
0.581
0.623
0.662
0.069
1.058
0.360
0.581
0.232
1.011
1.547
0.320
1.007
0.231
1.708
0.619
1.011
0.514
0.471
0.418
0.78
0.864
0.933
1.206
0.012
0.02
0.021
0.014
0.016
0.006
0.252
0.389
0.322
0.397
0.162
0.035
0.733
0.909
0.703
0.699
0.250
0.427
0.798
0.545
0.867
1.026
0.061
0.071
0.426
0.380
0.268
0.344
C-24
In Vitro
Score1
137.9
156.5
138.0
176.8
183.0
175.4
154.4
156.9
150.8
157.2
157.9
157.0
160.2
156.9
163.4
169.7
162.8
151.6
163.1
167.8
156.9
160.0
108.3
111.8
92.8
99.2
94.9
98.2
53.9
47.7
47.1
47.2
42.2
41.8
36.6
37.6
29.6
41.7
31.5
42.6
55.4
52.7
54.5
61.7
60.2
54.2
73.4
64.0
51.4
47.0
45.4
44.4
45.7
54.6
44.8
42.2
n
SD Score
3
3
3
2.3
18.6
0.1
3
3
3
3
3
11.1
18.6
7.1
18.0
3.4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
17.1
16.2
10.2
11.4
7.7
22.1
7.8
17.1
8.2
12.9
5.5
13
10.7
13.8
21.6
4.9
3.4
3.1
2.9
4.3
3.9
6.0
10.8
6.4
5.8
4.5
3
3
3
3
3
12.8
8.3
7.8
4.9
5.0
3
3
3
3
3
3
3
14.3
2.0
3.0
8.5
4.5
5.1
8.8
In Vitro
Consensus
Classification2
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Severe
Moderate
Moderate
Severe
Severe
Moderate
Severe
Severe
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Moderate
Classification3
Very Severe
Very Severe
Moderate
Moderate
Reference
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
In Vitro
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
n
SD Opacity
Mean
OD490
n
SD OD490
Glycerol
Glycerol
Glycerol
Glycerol
Glycerol
Glycerol
56-81-5
56-81-5
56-81-5
56-81-5
56-81-5
56-81-5
liquid
liquid
liquid
liquid
liquid
liquid
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
100%
100%
100%
100%
100%
100%
>99.5
>99.5
>99.5
>99.5
>99.5
>99.5
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
0.6
0.3
0.6
0.7
1.0
0.7
3
3
3
3
3
3
0.6
1.0
0.6
0.6
0.6
0.0
-0.005
-0.003
0.012
0.008
-0.003
0.007
3
3
3
3
3
3
0.002
0.002
0.007
0.009
0.005
0.011
Score1
0.6
0.3
0.8
0.8
1.0
0.8
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
1 (1)
13.3
3
2.0
0.654
3
0.273
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
1 (2)
9.7
3
4.2
0.499
3
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
2 (1)
13.7
3
3.2
1.398
3
Substance
In Vitro
Consensus
Classification3
0.6
1.0
0.6
0.7
0.6
0.2
Classification2
Mild
Mild
Nonirritant
Nonirritant
Nonirritant
Nonirritant
5.9
Mild
Southee (1998)
5.8
Mild
Southee (1998)
12.1
Moderate
n
SD Score
3
3
3
3
3
3
23.1
3
0.109
17.2
3
0.601
34.6
3
Nonirritant
Reference
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Moderate
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
2 (2)
13.0
3
4.4
1.743
3
0.871
39.1
3
16.4
Moderate
Southee (1998)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
3 (1)
17.3
3
1.0
0.958
3
0.100
31.7
3
2.3
Moderate
Southee (1998)
Hexadecyltrimethylammonium bromide
57-09-0
surfactant
n.p.
10%
n.p.
3 (2)
17.7
3
2.1
0.818
3
0.607
29.9
3
11.2
Moderate
Southee (1998)
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Imidazole
Methyl ethyl ketone
Methyl ethyl ketone
Methyl ethyl ketone
Methyl ethyl ketone
Methyl ethyl ketone
Methyl ethyl ketone
Parafluoraniline
Parafluoraniline
Parafluoraniline
Parafluoraniline
Parafluoraniline
Parafluoraniline
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
Propyl-4-hydroxybenzoate
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
288-32-4
78-93-3
78-93-3
78-93-3
78-93-3
78-93-3
78-93-3
371-40-4
371-40-4
371-40-4
371-40-4
371-40-4
371-40-4
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
94-13-3
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
water insoluble
water insoluble
water insoluble
water insoluble
water insoluble
water insoluble
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
20%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
20%
20%
20%
20%
20%
20%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
99
99
99
99
99
99
99
99
99
99
99
99
100
100
100
100
100
100
1 (1)
1 (2)
1 (3)
1 (4)
1 (5)
1 (6)
1 (7)
2 (1)
2 (2)
2 (3)
2 (4)
2 (5)
2 (6)
2 (7)
3 (1)
3 (2)
3 (3)
3 (4)
3 (5)
3 (6)
3 (7)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
91.3
88.0
73.7
86.0
97.0
115.3
70.3
85.7
88.0
86.3
92.3
88.0
97.3
100.0
83.0
91.7
80.4
82.3
76.6
76.3
77.3
47.6
48
61
62
55.7
54.4
15.3
16.3
13.3
16.0
11.0
15.4
10.7
7.0
5.0
3.4
7.3
5.6
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2.1
7.5
10.1
9.6
15.5
9.1
4.5
9.8
13.0
6.0
7.9
16.7
12.9
9.1
14.8
9.3
3.1
2.1
8.3
8.7
2.0
5.9
2.1
2.9
6.7
5.0
1.5
1.0
3.5
2.1
4.6
1.0
1.2
2.6
0.6
1.7
1.5
4.4
0.6
3.379
3.306
2.565
3.006
3.241
3.150
3.681
3.490
3.471
3.240
4.324
3.308
3.709
3.316
3.774
3.232
2.907
3.093
3.118
2.862
3.602
1.706
1.32
3.183
2.648
0.972
1.278
1.044
1.243
1.663
1.432
0.738
0.7
0.034
0.023
0.013
0.016
0.028
0.04
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
0.106
0.597
1.063
1.078
0.233
0.181
0.691
0.309
0.381
0.651
1.048
0.695
0.866
0.183
0.828
0.702
0.642
0.635
0.464
0.292
0.413
0.679
0.303
0.86
1.074
0.479
0.359
0.413
0.287
0.372
0.531
0.154
0.151
0.044
0.026
0.012
0.015
0.014
0.051
142.0
137.6
112.2
131.1
145.6
162.6
125.5
138.1
140.1
134.9
157.2
137.6
152.9
148.7
139.6
140.1
124.0
128.7
123.4
121.2
131.3
73.3
67.8
108.7
101.7
70.2
73.5
31
35
38.3
37.5
22.1
28.9
11.2
7.4
5.2
3.6
7.7
6.2
3
3
3
3
3
3
3
3
3
3
3
3
3.0
6.8
24.7
6.7
12.0
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
26.0
18.9
6.9
8.2
14.8
4.6
8.2
15.9
5.7
11.9
21.1
3.5
6.4
7.2
6.2
7.5
12.2
2.7
3.4
3.2
0.6
1.9
1.6
4.2
0.7
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Severe
Severe
Very severe
Very severe
Severe
Severe
Moderate
Moderate
Moderate
Moderate
Mild
Moderate
Mild
Mild
Mild
Mild
Mild
Mild
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
C-25
13.0
11.9
9.4
12.5
6.8
Very Severe
Severe
Moderate
Mild
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Substance
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium hydroxide (10%)
Sodium lauryl sulfate (15%)
Sodium lauryl sulfate (15%)
Sodium lauryl sulfate (15%)
Sodium lauryl sulfate (15%)
Sodium lauryl sulfate (15%)
Sodium lauryl sulfate (15%)
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Sodium oxalate
Triton X-100 (5%)
Triton X-100 (5%)
Triton X-100 (5%)
Triton X-100 (5%)
Triton X-100 (5%)
Triton X-100 (5%)
Tween 20
Tween 20
Tween 20
Tween 20
Tween 20
Tween 20
1-1 (#1)
1-2 (#2)
1-3 (#3)
2-4 (#4)
2-7 (#7)
2-8 (#8)
Benchmark-Group 1 (#12)
Benchmark-Group 2 (#13)
Ethanol (#14)
Toilet Bowl Cleaner (#1)
Toilet Bowl Cleaner (#4)
All Purpose Cleaner (#5)
Bathroom Cleaner (#6)
All Purpose Cleaner (#7)
Pot and Pan Cleaner (#8)
Heavy Duty Cleaner/Degreaser (#9)
Floor Cleaner (#10)
General Cleaner (#11)
General Cleaner (#12)
Cleaner/Degreaser (#13)
Floor Stripper (#14)
Heavy Duty Cleaner (#15)
Degreaser (#16)
Floor Stripper (#17)
Floor Stripper (#18)
Glass Cleaner (#19)
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
Mean
Opacity
n
SD Opacity
Mean
OD490
n
SD OD490
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
1310-73-2
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
151-21-3
62-76-0
62-76-0
62-76-0
62-76-0
62-76-0
62-76-0
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9002-93-1
9005-64-5
9005-64-5
9005-64-5
9005-64-5
9005-64-5
9005-64-5
64-17-5
-
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
solid
solid
solid
solid
solid
solid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
liquid
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
water soluble
water soluble
water soluble
water soluble
water soluble
water soluble
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
surfactant
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
10%
20%
20%
20%
20%
20%
20%
10%
10%
10%
10%
10%
10%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
100%
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
98
98
98
98
98
98
99
99
99
99
99
99
98
98
98
98
98
98
98
98
98
98
98
98
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
n.p.
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
1 (1)
1 (2)
2 (1)
2 (2)
3 (1)
3 (2)
-
176.7
172.0
170.0
166.7
124.0
165.3
-0.8
0.0
0.7
1.0
0.7
1.3
8.4
3.4
-1.0
-1.0
2.0
2.3
3.3
1.3
1.4
0.0
2.7
1.4
0.3
0.0
0.4
0.4
0.0
0.0
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
31.4
1.7
20.7
12.6
13.7
21.2
0.0
0.6
1.0
0.6
0.6
0.6
1.2
0.6
1.7
2.1
0.6
1.0
1.0
1.0
0.6
0.6
1.0
0.6
0.0
1.5
0.6
0.6
0.0
1.0
4.551
3.676
4.755
4.590
4.604
3.303
0.408
0.348
1.012
1.086
0.518
0.283
0.128
0.071
0.05
0.055
0.051
0.15
0.023
0.035
0.298
0.226
0.023
0.038
0.003
0.004
0.001
0.003
0.022
0.001
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
1.019
0.201
0.586
0.405
0.380
0.388
0.024
0.182
0.461
0.083
0.11
0.064
0.16
0.03
0.054
0.012
0.032
0.022
0.004
0.006
0.123
0.086
0.009
0.013
0.012
0.01
0.002
0.008
0.018
0.022
8.700
10.5
102.5
64
348.1
-1.8
315.4
45.2
77.9
95.5
314.3
122.5
323.3
225.4
180.5
407.1
98.3
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
C-26
0.323
0.303
1.252
0.95
3.013
0.078
2.619
1.675
0.359
1.197
2.623
2.318
2.24
2.022
2.38
2.481
2.499
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
In Vitro
Score1
245.0
227.1
241.3
235.5
193.1
214.9
5.4
5.2
15.9
17.3
8.7
5.6
10.3
4.4
-0.3
-0.1
2.7
4.5
3.7
1.8
5.8
3.4
3.0
1.9
0.3
0.0
0.4
0.4
0.3
0.0
83.6
12.4
29.6
7.3
21.4
31.8
60.1
60.1
52.7
13.5
15
121.3
78.3
393.3
-0.6
354.7
70.3
83.3
113.5
353.6
157.3
357.1
255.7
216.2
444.3
135.8
n
SD Score
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
28.7
3.4
11.9
7.3
19.0
15.5
0.4
2.7
7.6
1.7
1.4
1.5
1.4
1.0
1.5
2.1
0.9
1.3
1.1
1.0
2.4
1.0
1.1
0.6
0.2
1.6
0.6
0.5
0.3
1.3
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
In Vitro
Consensus
Classification2
Very severe
Very severe
Very severe
Very severe
Very severe
Very severe
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Mild
Nonirritant
Nonirritant
Nonirritant
Mild
Mild
Mild
Mild
Mild
Nonirritant
Nonirritant
Mild
Mild
Mild
Nonirritant
Nonirritant
Nonirritant
Severe
Mild
Moderate
Mild
Moderate
Moderate
Severe
Severe
Moderate
Mild
Mild
Severe
Severe
Severe
Nonirritant
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Classification3
Very Severe
Mild
Nonirritant
Mild
Nonirritant
Severe
Mild
Moderate
Mild
Moderate
Moderate
Severe
Severe
Moderate
Mild
Mild
Severe
Severe
Severe
Nonirritant
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Severe
Reference
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Southee (1998)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson and Harbell (2000)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
BCOP BRD: Appendix C1
March 2006
In Vitro Data for Substances Tested in the BCOP Assay: Sorted by Reference
Mean
SD Mean
SD n
n
Opacity
Opacity
OD490
OD490
344.2
5
3.182
5
Metal Cleaner (#20)
liquid
n.p.
100%
n.p.
-2.1
5
0.119
5
Floor Cleaner (#2)
liquid
n.p.
100%
n.p.
99.3
5
2.733
5
Meat Room Degreaser (#3)
liquid
n.p.
100%
n.p.
Abbreviations: CASRN=Chemical Abstract Services Registry Number; n=number of replicates; n.s.=not applicable; n.p.=not provided; OD=optical density; SD=standard deviation
Substance
CASRN
Form
Tested
Solubility
Concentration
Tested
Purity (%)
Lab
No.
In Vitro
Score1
391.9
-0.3
140.3
n
5
5
5
SD Score
In Vitro
Consensus
Classification2
Severe
Nonirritant
Severe
Classification3
Severe
Nonirritant
Severe
Reference
Swanson et al. (1995)
Swanson et al. (1995)
Swanson et al. (1995)
1
In Vitro Score = mean opacity socre + (15 x mean OD490 value) represents the BCOP ocular irritancy classification assigned for each chemical in the study for each test for a specific substance
2
In Vitro Classification represents the BCOP ocular irritancy classification assigned for each independent test result, according to the classification system used
3
Consensus call represents the overall BCOP ocular irritancy classification assigned for each chemical in the study based on the majority of ocular irritancy classification calls. When there was an even number of different irritancy classifications for a test substance, the more severe irritancy
classification was used for the overall classification for that test substance.
*solubility uncertain
C-27